Professor John Mitrofanis

Professor of Anatomy
Anatomy & Histology, School of Medical Sciences

Telephone 93512500
Fax 93512813

Map

Research interests

Neuroscience

Parkinson's disease

Neuroprotection

Teaching and supervision

Neuroanatomy / Head and Neck Anatomy

Current research students

Project title Research student
The effect of photobiomodulation on activity of the human brain Hala EL KHOURY

International links

France

(Clinatec, CEA, Grenoble) Neuroprotection of dopaminergic cells Parkinson's disease

United Kingdom

(UCL) Mechanisms of near infrared ligt in neuroprotection

Selected grants

2015

  • Common pathways in neuroprotection: understanding mechanisms of three neuroprotectants in a model of Parkinson’s disease; Johnstone D, Stone J, Mitrofanis J; Parkinsons New South Wales Incorporated/Research Grants.

2014

  • Protection against Parkinsons disease using remote photobiomodulation: understanding mechanisms; Johnstone D, Stone J, Mitrofanis J; Brain Foundation of Australia/Annual Research Awards.

2013

  • Mouse behavioural phenotyping battery; Hunt N, Christie M, McGregor I, Kassiou M, Collins M, Stone J, Arnold J, Sawatari A, Mitrofanis J, Camp A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Near Infra red; Mitrofanis J; Atomic Energy and Alternative Energies Commission (CEA)/Research Support.

2007

  • Helping Cells Survive In Parkinson Disease; Mitrofanis J; Tenix Pty Ltd/Research Support.

2004

  • Organisation of subcortical afferents to the thalamus; Mitrofanis J; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • maps in the thalamus: exploring a fresh role for zona incerta; Mitrofanis J; University of Sydney/Medicine Bridging.

2000

  • A novel view of zona incerta: a key thalamic relay to the neocortex; Mitrofanis J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The thalamic reticular nucleus: interrelationships between the cortex and thalamus; Fitzgibbon T, Mitrofanis J, Dreher B; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Eells, J., Gopalakrishnan, S., Salzman, M., Valter, K., Provis, J., Natoli, R., Mitrofanis, J., Stone, J., Fitzgerald, M. (2017). Low-level laser (light) therapy for the treatment of visual system injury and disease. In M R Hamblin, M V Pires de Sousa, T Agrawal (Eds.), Handbook of Low-Level Laser Therapy, (pp. 435-452). Singapore: Pan Stanford Publishing. [More Information]
  • Johnstone, D., Moro, C., Stone, J., Benabid, A., Mitrofanis, J. (2017). Shining a light on Parkinson's disease. In M R Hamblin, M V Pires de Sousa, T Agrawal (Eds.), Handbook of Low-Level Laser Therapy, (pp. 237-252). Singapore: Pan Stanford Publishing. [More Information]
  • Benabid, A., Mitrofanis, J., Chabardes, S., Seigneuret, E., Torres, N., Piallat, B., Benazzouz, A., Fraix, V., Krack, P., Pollak, P., et al (2011). Subthalamic deep brain stimulation for Parkinson's disease. In H. Richard Winn, Julian R. Youmans (Eds.), Youmans Neurological Surgery, (pp. 944-962). Philadelphia: Elsevier - Health Sciences Division.

Journals

  • Moro, C., Torres, N., Arvanitakis, K., Cullen, K., Chabrol, C., Agay, D., Darlot, F., Benabid, A., Mitrofanis, J. (2017). No evidence for toxicity after long-term photobiomodulation in normal non-human primates. Experimental Brain Research, 235(10), 3081-3092. [More Information]
  • El Massri, N., Lemgruber, A., Rowe, I., Moro, C., Torres, N., Reinhart, F., Chabrol, C., Benabid, A., Mitrofanis, J. (2017). Photobiomodulation-induced changes in a monkey model of Parkinson�s disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum. Experimental Brain Research, 235(6), 1861-1874. [More Information]
  • Kim, B., Brandli, A., Mitrofanis, J., Stone, J., Purushothuman, S., Johnstone, D. (2017). Remote tissue conditioning � An emerging approach for inducing body-wide protection against diseases of ageing. Ageing Research Reviews, 37, 69-78. [More Information]
  • Reinhart, F., El Massri, N., Torres, N., Chabrol, C., Molet, J., Johnstone, D., Stone, J., Benabid, A., Mitrofanis, J., Moro, C. (2017). The behavioural and neuroprotective outcomes when 670�nm and 810�nm near infrared light are applied together in MPTP-treated mice. Neuroscience Research, 117, 42-47. [More Information]
  • Mitrofanis, J. (2017). Why and how does light therapy offer neuroprotection in Parkinson's disease? Neural Regeneration Research, 12(4), 574-575. [More Information]
  • Moro, C., El Massri, N., Darlot, F., Torres, N., Chabrol, C., Agay, D., Auboiroux, V., Johnstone, D., Stone, J., Mitrofanis, J., et al (2016). Effects of a higher dose of near-infrared light on clinical signs and neuroprotection in a monkey model of Parkinson's disease. Brain Research, 1648, 19-26. [More Information]
  • Mitrofanis, J., Moro, C., Benabid, A. (2016). Further analysis of the neuroprotective effect of near-infrared light in a monkey model of Parkinson disease. Annals of Neurology, 80(2), 310-311. [More Information]
  • Reinhart, F., El Massri, N., Chabrol, C., Cretallaz, C., Johnstone, D., Torres, N., Darlot, F., Costecalde, T., Stone, J., Mitrofanis, J., et al (2016). Intracranial application of near-infrared light in a hemi-parkinsonian rat model: The impact on behavior and cell survival. Journal of Neurosurgery, 124(6), 1829-1841. [More Information]
  • Reinhart, F., El Massri, N., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A., Moro, C. (2016). Near-infrared light (670 nm) reduces MPTP-induced parkinsonism within a broad therapeutic time window. Experimental Brain Research, 234(7), 1787-1794. [More Information]
  • Darlot, F., Moro, C., El Massri, N., Chabrol, C., Johnstone, D., Reinhart, F., Agay, D., Torres, N., Bekha, D., Auboiroux, V., Peoples, C., Anastascio, H., Shaw, V., Stone, J., Mitrofanis, J., et al (2016). Near-infrared light is neuroprotective in a monkey model of Parkinson disease. Annals of Neurology, 79(1), 59-75. [More Information]
  • El Massri, N., Moro, C., Torres, N., Darlot, F., Agay, D., Chabrol, C., Johnstone, D., Stone, J., Benabid, A., Mitrofanis, J. (2016). Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys. Experimental Brain Research, 234(11), 3225-3232. [More Information]
  • El Massri, N., Johnstone, D., Peoples, C., Moro, C., Reinhart, F., Torres, N., Stone, J., Benabid, A., Mitrofanis, J. (2016). The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice. International Journal of Neuroscience, 126(1), 76-87. [More Information]
  • Johnstone, D., Moro, C., Stone, J., Benabid, A., Mitrofanis, J. (2016). Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease. Frontiers in Neuroscience, 9, 1-15. [More Information]
  • Skladnev, N., Ganeshan, V., Kim, J., Burton, T., Mitrofanis, J., Stone, J., Johnstone, D. (2016). Widespread brain transcriptome alterations underlie the neuroprotective actions of dietary saffron. Journal of Neurochemistry, 139(5), 858-871. [More Information]
  • Reinhart, F., El Massri, N., Darlot, F., Torres, N., Johnstone, D., Chabrol, C., Costecalde, T., Stone, J., Mitrofanis, J., Benabid, A., et al (2015). 810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice. Neuroscience Research, 92, 86-90. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasenaa,, C., van Eersel, J., Ittner, L., Mitrofanis, J., Stone, J. (2015). Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia. Neuroscience Letters, 591, 155-159. [More Information]
  • Johnstone, D., Mitrofanis, J., Stone, J. (2015). Targeting the body to protect the brain: Inducing neuroprotection with remotely-applied near infrared light. Neural Regeneration Research, 10(3), 349-351. [More Information]
  • Stone, J., Johnstone, D., Mitrofanis, J., O'Rourke, M. (2015). The Mechanical Cause of Age-Related Dementia (Alzheimer's Disease): The Brain is Destroyed by the Pulse. Journal of Alzheimer's Disease, 44(2), 355-373. [More Information]
  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274, 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Johnstone, D., Coleman, K., Moro, C., Torres, N., Eells, J., Baker, G., Ashkan, K., Stone, J., Benabid, A., Mitrofanis, J. (2014). The potential of light therapy in Parkinson's disease. ChronoPhysiology and Therapy, 4, 1-14. [More Information]
  • Moro, C., Torres, N., El Massri, N., Ratel, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A. (2013). Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. BMC Neuroscience, 14(1), 1-9. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]
  • Shaw, V., Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice. Parkinson's Disease, 2012, 1-9. [More Information]
  • Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease. Parkinsonism and Related Disorders, 18(5), 468-476. [More Information]
  • Peoples, C., Shaw, V., Stone, J., Jeffery, G., Baker, G., Mitrofanis, J. (2012). Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice. ISRN Neurology, 2012, 1-8. [More Information]
  • Shaw, V., Keay, K., Ashkan, K., Benabid, A., Mitrofanis, J. (2010). Dopaminergic cells in the periaqueductal grey matter of MPTP-treated monkeys and mice; patterns of survival and effect of deep brain stimulation and lesion of the subthalamic nucleus. Parkinsonism and Related Disorders, 16(5), 338-344. [More Information]
  • Shaw, V., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2010). Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment. The Journal of Comparative Neurology, 518(1), 25-40. [More Information]
  • Benabid, A., Chabardes, S., Mitrofanis, J., Pollak, P. (2009). Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. The Lancet Neurology, 8(1), 67-81. [More Information]
  • Ma, J., Shaw, V., Mitrofanis, J. (2009). Does melatonin help save dopaminergic cells in MPTP-treated mice? Parkinsonism and Related Disorders, 15(4), 307-314. [More Information]
  • Reyes, S., Mitrofanis, J. (2008). Patterns of FOS expression in the spinal cord and periaqueductal grey matter of 6OHDA-lesioned rats. International Journal of Neuroscience, 118(8), 1053-1079. [More Information]
  • Heise, C., Reyes, S., Mitrofanis, J. (2008). Sensory (nociceptive) stimulation evokes Fos expression in the subthalamus of hemiparkinsonian rats. Neurological research, 30(3), 277-284. [More Information]
  • Luquin, N., Mitrofanis, J. (2007). Does the cerebral cortex exacerbate dopaminergic cell death in the substantia nigra of 6OHDA-lesioned rats? Parkinsonism and Related Disorders, doi:10.1016/j.parkreldis.2007.08.010(14(3)), 213-223. [More Information]
  • Ashkan, K., Wallace, B., Mitrofanis, J., Pollo, C., Brard, P., Fagret, D., Benabid, A. (2007). SPECT imaging, immunohistochemical and behavioural correlations in the primate models of Parkinson''s disease. Parkinsonism and Related Disorders, 13(5), 266-275. [More Information]
  • Wallace, B., Ashkan, K., Heise, C., Foote, K., Torres, N., Mitrofanis, J., Benabid, A. (2007). Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys. Brain, 130(8), 2129-2145. [More Information]
  • Heise, C., Mitrofanis, J. (2006). Fos immunoreactivity in some locomotor neural centres of 6OHDA-lesioned rats. Anatomy and Embryology (Brain Structure and Function), 211(6), 659-671. [More Information]
  • Mitrofanis, J., Benabid, A., Wallace, B., Xia, R., Piallat, B., Chabardes, S., Berger, F. (2005). A putative generalized model of the effects and mechanism of action of high frequency electrical stimulation of the central nervous system. Acta neurologica Belgica, 105(3), 149-57. [More Information]
  • Heise, C., Teo, Z., Wallace, B., Ashkan, K., Benabid, A., Mitrofanis, J. (2005). Cell survival patterns in the pedunculopontine tegmental nucleus of methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys and 6OHDA-lesioned rats: evidence for differences to idiopathic Parkinson disease patients? Anatomy and Embryology (Brain Structure and Function), 210(4), 287-302. [More Information]
  • Fitzpatrick, E., Ashkan, K., Wallace, B., Benabid, A., Mitrofanis, J. (2005). Differential survival patterns among midbrain dopaminergic cells of MPTP-treated monkeys and 6OHDA-lesioned rats. Anatomy and Embryology (Brain Structure and Function), 210(2), 101-23. [More Information]
  • Heise, C., Mitrofanis, J. (2005). Reduction in parvalbumin expression in the zona incerta after 6OHDA lesion in rats. Brain Cell Biology, 34(6), 421-434. [More Information]
  • Mitrofanis, J. (2005). Some certainty for the "zone of uncertainty"? exploring the function of the zona incerta. Neuroscience, 130(1), 1-15. [More Information]
  • Benabid, A., Wallace, B., Mitrofanis, J., Xia, C., Piallat, B., Fraix, V., Batir, A., Krack, P., Pollak, P., Berger, F. (2005). Therapeutic electrical stimulation of the central nervous system. Comptes Rendus de L'academie des Sciences. Biologies, 328(2), 177-186. [More Information]
  • Mitrofanis, J., Ashkan, K., Wallace, B., Benabid, A. (2004). Chemoarchitectonic Heterogeneities In The Primate Zona Incerta: Clinical And Functional Implications. Brain Cell Biology, 33(4), 429-440. [More Information]
  • Heise, C., Mitrofanis, J. (2004). Evidence For A Glutamatergic Projection From The Zona Incerta To The Basal Ganglia Of Rats. The Journal of Comparative Neurology, 468(4), 482-495. [More Information]
  • Shaw, V., Mitrofanis, J. (2003). Anatomical eveidence for somatotopic maps in the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 11, 119-130.
  • Power, B., Mitrofanis, J. (2003). Ultrastructure of afferents from the zona incerta to the posterior and parafascicular thalamic nuclei of rats. The Journal of Comparative Neurology, 451(1), 33-44. [More Information]
  • Shaw, V., Mitrofanis, J. (2002). Anatomical evidence for somatotopic maps in the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 206(1-2), 119-130. [More Information]
  • Mitrofanis, J. (2002). Distinctive patterns of connectivity between the zona incerta and the red nucleus of rats. Anatomy and Embryology (Brain Structure and Function), 205(4), 283-289. [More Information]
  • Mitrofanis, J. (2002). Evidence for an auditory subsector within the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 205(5-6), 453-462. [More Information]
  • Power, B., Leamey, C., Mitrofanis, J. (2001). Evidence for a visual subsector within the zona incerta. Visual Neuroscience, 18 (2), 179-186.
  • Kolmac, C., Mitrofanis, J. (2001). Induction of Fos-like immunoreactivity in the ventral thalamus after electrical or chemical stimulation of various subcortical centres of rats. Neuroscience Letters, 301 (3), 195-198.
  • Mitrofanis, J., DeFonseka, R. (2001). Organisation of connections between the zona incerta and the interposed nucleus. Anatomy and Embryology (Brain Structure and Function), 204 (2), 153-159.
  • Power, B., Mitrofanis, J. (2001). Zona Incerta: Substrate fro contralateral interconnectivity in the thalamus of rats. The Journal of Comparative Neurology, 436 (1), 52-63.

Conferences

  • Stone, J., Johnstone, D., Mitrofanis, J. (2013). The helmet experiment in Parkinson's disease: an observation of the mechanism of neuroprotection by near infra-red light. The 9th World Association for Laser Therapy Congress, Bologna, Italy: Medimond International Proceedings.

2017

  • Eells, J., Gopalakrishnan, S., Salzman, M., Valter, K., Provis, J., Natoli, R., Mitrofanis, J., Stone, J., Fitzgerald, M. (2017). Low-level laser (light) therapy for the treatment of visual system injury and disease. In M R Hamblin, M V Pires de Sousa, T Agrawal (Eds.), Handbook of Low-Level Laser Therapy, (pp. 435-452). Singapore: Pan Stanford Publishing. [More Information]
  • Moro, C., Torres, N., Arvanitakis, K., Cullen, K., Chabrol, C., Agay, D., Darlot, F., Benabid, A., Mitrofanis, J. (2017). No evidence for toxicity after long-term photobiomodulation in normal non-human primates. Experimental Brain Research, 235(10), 3081-3092. [More Information]
  • El Massri, N., Lemgruber, A., Rowe, I., Moro, C., Torres, N., Reinhart, F., Chabrol, C., Benabid, A., Mitrofanis, J. (2017). Photobiomodulation-induced changes in a monkey model of Parkinson�s disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum. Experimental Brain Research, 235(6), 1861-1874. [More Information]
  • Kim, B., Brandli, A., Mitrofanis, J., Stone, J., Purushothuman, S., Johnstone, D. (2017). Remote tissue conditioning � An emerging approach for inducing body-wide protection against diseases of ageing. Ageing Research Reviews, 37, 69-78. [More Information]
  • Johnstone, D., Moro, C., Stone, J., Benabid, A., Mitrofanis, J. (2017). Shining a light on Parkinson's disease. In M R Hamblin, M V Pires de Sousa, T Agrawal (Eds.), Handbook of Low-Level Laser Therapy, (pp. 237-252). Singapore: Pan Stanford Publishing. [More Information]
  • Reinhart, F., El Massri, N., Torres, N., Chabrol, C., Molet, J., Johnstone, D., Stone, J., Benabid, A., Mitrofanis, J., Moro, C. (2017). The behavioural and neuroprotective outcomes when 670�nm and 810�nm near infrared light are applied together in MPTP-treated mice. Neuroscience Research, 117, 42-47. [More Information]
  • Mitrofanis, J. (2017). Why and how does light therapy offer neuroprotection in Parkinson's disease? Neural Regeneration Research, 12(4), 574-575. [More Information]

2016

  • Moro, C., El Massri, N., Darlot, F., Torres, N., Chabrol, C., Agay, D., Auboiroux, V., Johnstone, D., Stone, J., Mitrofanis, J., et al (2016). Effects of a higher dose of near-infrared light on clinical signs and neuroprotection in a monkey model of Parkinson's disease. Brain Research, 1648, 19-26. [More Information]
  • Mitrofanis, J., Moro, C., Benabid, A. (2016). Further analysis of the neuroprotective effect of near-infrared light in a monkey model of Parkinson disease. Annals of Neurology, 80(2), 310-311. [More Information]
  • Reinhart, F., El Massri, N., Chabrol, C., Cretallaz, C., Johnstone, D., Torres, N., Darlot, F., Costecalde, T., Stone, J., Mitrofanis, J., et al (2016). Intracranial application of near-infrared light in a hemi-parkinsonian rat model: The impact on behavior and cell survival. Journal of Neurosurgery, 124(6), 1829-1841. [More Information]
  • Reinhart, F., El Massri, N., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A., Moro, C. (2016). Near-infrared light (670 nm) reduces MPTP-induced parkinsonism within a broad therapeutic time window. Experimental Brain Research, 234(7), 1787-1794. [More Information]
  • Darlot, F., Moro, C., El Massri, N., Chabrol, C., Johnstone, D., Reinhart, F., Agay, D., Torres, N., Bekha, D., Auboiroux, V., Peoples, C., Anastascio, H., Shaw, V., Stone, J., Mitrofanis, J., et al (2016). Near-infrared light is neuroprotective in a monkey model of Parkinson disease. Annals of Neurology, 79(1), 59-75. [More Information]
  • El Massri, N., Moro, C., Torres, N., Darlot, F., Agay, D., Chabrol, C., Johnstone, D., Stone, J., Benabid, A., Mitrofanis, J. (2016). Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys. Experimental Brain Research, 234(11), 3225-3232. [More Information]
  • El Massri, N., Johnstone, D., Peoples, C., Moro, C., Reinhart, F., Torres, N., Stone, J., Benabid, A., Mitrofanis, J. (2016). The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice. International Journal of Neuroscience, 126(1), 76-87. [More Information]
  • Johnstone, D., Moro, C., Stone, J., Benabid, A., Mitrofanis, J. (2016). Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease. Frontiers in Neuroscience, 9, 1-15. [More Information]
  • Skladnev, N., Ganeshan, V., Kim, J., Burton, T., Mitrofanis, J., Stone, J., Johnstone, D. (2016). Widespread brain transcriptome alterations underlie the neuroprotective actions of dietary saffron. Journal of Neurochemistry, 139(5), 858-871. [More Information]

2015

  • Reinhart, F., El Massri, N., Darlot, F., Torres, N., Johnstone, D., Chabrol, C., Costecalde, T., Stone, J., Mitrofanis, J., Benabid, A., et al (2015). 810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice. Neuroscience Research, 92, 86-90. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasenaa,, C., van Eersel, J., Ittner, L., Mitrofanis, J., Stone, J. (2015). Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia. Neuroscience Letters, 591, 155-159. [More Information]
  • Johnstone, D., Mitrofanis, J., Stone, J. (2015). Targeting the body to protect the brain: Inducing neuroprotection with remotely-applied near infrared light. Neural Regeneration Research, 10(3), 349-351. [More Information]
  • Stone, J., Johnstone, D., Mitrofanis, J., O'Rourke, M. (2015). The Mechanical Cause of Age-Related Dementia (Alzheimer's Disease): The Brain is Destroyed by the Pulse. Journal of Alzheimer's Disease, 44(2), 355-373. [More Information]

2014

  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274, 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Johnstone, D., Coleman, K., Moro, C., Torres, N., Eells, J., Baker, G., Ashkan, K., Stone, J., Benabid, A., Mitrofanis, J. (2014). The potential of light therapy in Parkinson's disease. ChronoPhysiology and Therapy, 4, 1-14. [More Information]

2013

  • Moro, C., Torres, N., El Massri, N., Ratel, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A. (2013). Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. BMC Neuroscience, 14(1), 1-9. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Stone, J., Johnstone, D., Mitrofanis, J. (2013). The helmet experiment in Parkinson's disease: an observation of the mechanism of neuroprotection by near infra-red light. The 9th World Association for Laser Therapy Congress, Bologna, Italy: Medimond International Proceedings.
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]

2012

  • Shaw, V., Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice. Parkinson's Disease, 2012, 1-9. [More Information]
  • Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease. Parkinsonism and Related Disorders, 18(5), 468-476. [More Information]
  • Peoples, C., Shaw, V., Stone, J., Jeffery, G., Baker, G., Mitrofanis, J. (2012). Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice. ISRN Neurology, 2012, 1-8. [More Information]

2011

  • Benabid, A., Mitrofanis, J., Chabardes, S., Seigneuret, E., Torres, N., Piallat, B., Benazzouz, A., Fraix, V., Krack, P., Pollak, P., et al (2011). Subthalamic deep brain stimulation for Parkinson's disease. In H. Richard Winn, Julian R. Youmans (Eds.), Youmans Neurological Surgery, (pp. 944-962). Philadelphia: Elsevier - Health Sciences Division.

2010

  • Shaw, V., Keay, K., Ashkan, K., Benabid, A., Mitrofanis, J. (2010). Dopaminergic cells in the periaqueductal grey matter of MPTP-treated monkeys and mice; patterns of survival and effect of deep brain stimulation and lesion of the subthalamic nucleus. Parkinsonism and Related Disorders, 16(5), 338-344. [More Information]
  • Shaw, V., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2010). Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment. The Journal of Comparative Neurology, 518(1), 25-40. [More Information]

2009

  • Benabid, A., Chabardes, S., Mitrofanis, J., Pollak, P. (2009). Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. The Lancet Neurology, 8(1), 67-81. [More Information]
  • Ma, J., Shaw, V., Mitrofanis, J. (2009). Does melatonin help save dopaminergic cells in MPTP-treated mice? Parkinsonism and Related Disorders, 15(4), 307-314. [More Information]

2008

  • Reyes, S., Mitrofanis, J. (2008). Patterns of FOS expression in the spinal cord and periaqueductal grey matter of 6OHDA-lesioned rats. International Journal of Neuroscience, 118(8), 1053-1079. [More Information]
  • Heise, C., Reyes, S., Mitrofanis, J. (2008). Sensory (nociceptive) stimulation evokes Fos expression in the subthalamus of hemiparkinsonian rats. Neurological research, 30(3), 277-284. [More Information]

2007

  • Luquin, N., Mitrofanis, J. (2007). Does the cerebral cortex exacerbate dopaminergic cell death in the substantia nigra of 6OHDA-lesioned rats? Parkinsonism and Related Disorders, doi:10.1016/j.parkreldis.2007.08.010(14(3)), 213-223. [More Information]
  • Ashkan, K., Wallace, B., Mitrofanis, J., Pollo, C., Brard, P., Fagret, D., Benabid, A. (2007). SPECT imaging, immunohistochemical and behavioural correlations in the primate models of Parkinson''s disease. Parkinsonism and Related Disorders, 13(5), 266-275. [More Information]
  • Wallace, B., Ashkan, K., Heise, C., Foote, K., Torres, N., Mitrofanis, J., Benabid, A. (2007). Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys. Brain, 130(8), 2129-2145. [More Information]

2006

  • Heise, C., Mitrofanis, J. (2006). Fos immunoreactivity in some locomotor neural centres of 6OHDA-lesioned rats. Anatomy and Embryology (Brain Structure and Function), 211(6), 659-671. [More Information]

2005

  • Mitrofanis, J., Benabid, A., Wallace, B., Xia, R., Piallat, B., Chabardes, S., Berger, F. (2005). A putative generalized model of the effects and mechanism of action of high frequency electrical stimulation of the central nervous system. Acta neurologica Belgica, 105(3), 149-57. [More Information]
  • Heise, C., Teo, Z., Wallace, B., Ashkan, K., Benabid, A., Mitrofanis, J. (2005). Cell survival patterns in the pedunculopontine tegmental nucleus of methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys and 6OHDA-lesioned rats: evidence for differences to idiopathic Parkinson disease patients? Anatomy and Embryology (Brain Structure and Function), 210(4), 287-302. [More Information]
  • Fitzpatrick, E., Ashkan, K., Wallace, B., Benabid, A., Mitrofanis, J. (2005). Differential survival patterns among midbrain dopaminergic cells of MPTP-treated monkeys and 6OHDA-lesioned rats. Anatomy and Embryology (Brain Structure and Function), 210(2), 101-23. [More Information]
  • Heise, C., Mitrofanis, J. (2005). Reduction in parvalbumin expression in the zona incerta after 6OHDA lesion in rats. Brain Cell Biology, 34(6), 421-434. [More Information]
  • Mitrofanis, J. (2005). Some certainty for the "zone of uncertainty"? exploring the function of the zona incerta. Neuroscience, 130(1), 1-15. [More Information]
  • Benabid, A., Wallace, B., Mitrofanis, J., Xia, C., Piallat, B., Fraix, V., Batir, A., Krack, P., Pollak, P., Berger, F. (2005). Therapeutic electrical stimulation of the central nervous system. Comptes Rendus de L'academie des Sciences. Biologies, 328(2), 177-186. [More Information]

2004

  • Mitrofanis, J., Ashkan, K., Wallace, B., Benabid, A. (2004). Chemoarchitectonic Heterogeneities In The Primate Zona Incerta: Clinical And Functional Implications. Brain Cell Biology, 33(4), 429-440. [More Information]
  • Heise, C., Mitrofanis, J. (2004). Evidence For A Glutamatergic Projection From The Zona Incerta To The Basal Ganglia Of Rats. The Journal of Comparative Neurology, 468(4), 482-495. [More Information]

2003

  • Shaw, V., Mitrofanis, J. (2003). Anatomical eveidence for somatotopic maps in the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 11, 119-130.
  • Power, B., Mitrofanis, J. (2003). Ultrastructure of afferents from the zona incerta to the posterior and parafascicular thalamic nuclei of rats. The Journal of Comparative Neurology, 451(1), 33-44. [More Information]

2002

  • Shaw, V., Mitrofanis, J. (2002). Anatomical evidence for somatotopic maps in the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 206(1-2), 119-130. [More Information]
  • Mitrofanis, J. (2002). Distinctive patterns of connectivity between the zona incerta and the red nucleus of rats. Anatomy and Embryology (Brain Structure and Function), 205(4), 283-289. [More Information]
  • Mitrofanis, J. (2002). Evidence for an auditory subsector within the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 205(5-6), 453-462. [More Information]

2001

  • Power, B., Leamey, C., Mitrofanis, J. (2001). Evidence for a visual subsector within the zona incerta. Visual Neuroscience, 18 (2), 179-186.
  • Kolmac, C., Mitrofanis, J. (2001). Induction of Fos-like immunoreactivity in the ventral thalamus after electrical or chemical stimulation of various subcortical centres of rats. Neuroscience Letters, 301 (3), 195-198.
  • Mitrofanis, J., DeFonseka, R. (2001). Organisation of connections between the zona incerta and the interposed nucleus. Anatomy and Embryology (Brain Structure and Function), 204 (2), 153-159.
  • Power, B., Mitrofanis, J. (2001). Zona Incerta: Substrate fro contralateral interconnectivity in the thalamus of rats. The Journal of Comparative Neurology, 436 (1), 52-63.

To update your profile click here. For support on your academic profile contact .