Professor John Mitrofanis

Professor of Anatomy
Anatomy & Histology, School of Medical Sciences

Telephone 93512500
Fax 93512813

Map

Research interests

Neuroscience

Parkinson's disease

Neuroprotection

Teaching and supervision

Neuroanatomy / Head and Neck Anatomy

International links

France

(Clinatec, CEA, Grenoble) Neuroprotection of dopaminergic cells Parkinson's disease

United Kingdom

(UCL) Mechanisms of near infrared ligt in neuroprotection

Selected grants

2014

  • Protection against Parkinsons disease using remote photobiomodulation: understanding mechanisms; Johnstone D, Stone J, Mitrofanis J; Brain Foundation of Australia/Annual Research Awards.

2013

  • Mouse behavioural phenotyping battery; Hunt N, Christie M, McGregor I, Kassiou M, Collins M, Stone J, Arnold J, Sawatari A, Mitrofanis J, Camp A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Near Infra red; Mitrofanis J; Atomic Energy and Alternative Energies Commission (CEA)/Research Support.

2007

  • Helping Cells Survive In Parkinson Disease; Mitrofanis J; Tenix Pty Ltd/Research Support.

2004

  • Organisation of subcortical afferents to the thalamus; Mitrofanis J; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • maps in the thalamus: exploring a fresh role for zona incerta; Mitrofanis J; University of Sydney/Medicine Bridging.

2000

  • The thalamic reticular nucleus: interrelationships between the cortex and thalamus; Fitzgibbon T, Mitrofanis J, Dreher B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A novel view of zona incerta: a key thalamic relay to the neocortex; Mitrofanis J; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Benabid, A., Mitrofanis, J., Chabardes, S., Seigneuret, E., Torres, N., Piallat, B., Benazzouz, A., Fraix, V., Krack, P., Pollak, P., et al (2011). Subthalamic deep brain stimulation for Parkinson's disease. In H. Richard Winn, Julian R. Youmans (Eds.), Youmans Neurological Surgery, (pp. 944-962). Philadelphia: Elsevier - Health Sciences Division.

Journals

  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274(C), 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Johnstone, D., Coleman, K., Moro, C., Torres, N., Eells, J., Baker, G., Ashkan, K., Stone, J., Benabid, A., Mitrofanis, J. (2014). The potential of light therapy in Parkinson's disease. ChronoPhysiology and Therapy, 4, 1-14. [More Information]
  • Moro, C., Torres, N., El Massri, N., Ratel, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A. (2013). Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. BMC Neuroscience, 14(1), 1-9. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]
  • Shaw, V., Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice. Parkinson's Disease, 2012, 1-9. [More Information]
  • Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease. Parkinsonism & Related Disorders, 18(5), 468-476. [More Information]
  • Peoples, C., Shaw, V., Stone, J., Jeffery, G., Baker, G., Mitrofanis, J. (2012). Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice. ISRN Neurology, 2012, 1-8. [More Information]
  • Shaw, V., Keay, K., Ashkan, K., Benabid, A., Mitrofanis, J. (2010). Dopaminergic cells in the periaqueductal grey matter of MPTP-treated monkeys and mice; patterns of survival and effect of deep brain stimulation and lesion of the subthalamic nucleus. Parkinsonism and Related Disorders, 16(5), 338-344. [More Information]
  • Shaw, V., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2010). Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment. The Journal of Comparative Neurology, 518(1), 25-40. [More Information]
  • Benabid, A., Chabardes, S., Mitrofanis, J., Pollak, P. (2009). Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Lancet Neurology, 8(1), 67-81. [More Information]
  • Ma, J., Shaw, V., Mitrofanis, J. (2009). Does melatonin help save dopaminergic cells in MPTP-treated mice? Parkinsonism and Related Disorders, 15(4), 307-314. [More Information]
  • Reyes, S., Mitrofanis, J. (2008). Patterns of FOS expression in the spinal cord and periaqueductal grey matter of 6OHDA-lesioned rats. International Journal of Neuroscience, 118(8), 1053-1079. [More Information]
  • Heise, C., Reyes, S., Mitrofanis, J. (2008). Sensory (nociceptive) stimulation evokes Fos expression in the subthalamus of hemiparkinsonian rats. Neurological research, 30(3), 277-284. [More Information]
  • Luquin, N., Mitrofanis, J. (2007). Does the cerebral cortex exacerbate dopaminergic cell death in the substantia nigra of 6OHDA-lesioned rats? Parkinsonism and Related Disorders, doi:10.1016/j.parkreldis.2007.08.010(14(3)), 213-223. [More Information]
  • Ashkan, K., Wallace, B., Mitrofanis, J., Pollo, C., Brard, P., Fagret, D., Benabid, A. (2007). SPECT imaging, immunohistochemical and behavioural correlations in the primate models of Parkinson''s disease. Parkinsonism and Related Disorders, 13(5), 266-275.
  • Wallace, B., Ashkan, K., Heise, C., Foote, K., Torres, N., Mitrofanis, J., Benabid, A. (2007). Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys. Brain, 130(8), 2129-2145. [More Information]
  • Heise, C., Mitrofanis, J. (2006). Fos immunoreactivity in some locomotor neural centres of 6OHDA-lesioned rats. Anatomy and Embryology (Brain Structure and Function), 211(6), 659-671. [More Information]
  • Mitrofanis, J., Benabid, A., Wallace, B., Xia, R., Piallat, B., Chabardes, S., Berger, F. (2005). A putative generalized model of the effects and mechanism of action of high frequency electrical stimulation of the central nervous system. Acta neurologica Belgica, 105(3), 149-57. [More Information]
  • Heise, C., Teo, Z., Wallace, B., Ashkan, K., Benabid, A., Mitrofanis, J. (2005). Cell survival patterns in the pedunculopontine tegmental nucleus of methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys and 6OHDA-lesioned rats: evidence for differences to idiopathic Parkinson disease patients? Anatomy and Embryology (Brain Structure and Function), 210(4), 287-302. [More Information]
  • Fitzpatrick, E., Ashkan, K., Wallace, B., Benabid, A., Mitrofanis, J. (2005). Differential survival patterns among midbrain dopaminergic cells of MPTP-treated monkeys and 6OHDA-lesioned rats. Anatomy and Embryology (Brain Structure and Function), 210(2), 101-23. [More Information]
  • Heise, C., Mitrofanis, J. (2005). Reduction in parvalbumin expression in the zona incerta after 6OHDA lesion in rats. Brain Cell Biology, 34(6), 421-34. [More Information]
  • Mitrofanis, J. (2005). Some certainty for the "zone of uncertainty"? exploring the function of the zona incerta. Neuroscience, 130(1), 1-15.
  • Benabid, A., Wallace, B., Mitrofanis, J., Xia, C., Piallat, B., Fraix, V., Batir, A., Krack, P., Pollak, P., Berger, F. (2005). Therapeutic electrical stimulation of the central nervous system. Comptes Rendus de L'academie des Sciences. Biologies, 328(2), 177-186. [More Information]
  • Mitrofanis, J., Ashkan, K., Wallace, B., Benabid, A. (2004). Chemoarchitectonic Heterogeneities In The Primate Zona Incerta: Clinical And Functional Implications. Brain Cell Biology, 33(4), 429-440.
  • Heise, C., Mitrofanis, J. (2004). Evidence For A Glutamatergic Projection From The Zona Incerta To The Basal Ganglia Of Rats. The Journal of Comparative Neurology, 468(4), 482-495. [More Information]
  • Shaw, V., Mitrofanis, J. (2003). Anatomical eveidence for somatotopic maps in the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 11, 119-130.
  • Power, B., Mitrofanis, J. (2003). Ultrastructure of afferents from the zona incerta to the posterior and parafascicular thalamic nuclei of rats. The Journal of Comparative Neurology, 451(1), 33-44. [More Information]
  • Shaw, V., Mitrofanis, J. (2002). Anatomical evidence for somatotopic maps in the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 206(1-2), 119-130. [More Information]
  • Mitrofanis, J. (2002). Distinctive patterns of connectivity between the zona incerta and the red nucleus of rats. Anatomy and Embryology (Brain Structure and Function), 205(4), 283-289. [More Information]
  • Mitrofanis, J. (2002). Evidence for an auditory subsector within the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 205(5-6), 453-462. [More Information]
  • Power, B., Leamey, C., Mitrofanis, J. (2001). Evidence for a visual subsector within the zona incerta. Visual Neuroscience, 18 (2), 179-186.
  • Kolmac, C., Mitrofanis, J. (2001). Induction of Fos-like immunoreactivity in the ventral thalamus after electrical or chemical stimulation of various subcortical centres of rats. Neuroscience Letters, 301 (3), 195-198.
  • Mitrofanis, J., DeFonseka, R. (2001). Organisation of connections between the zona incerta and the interposed nucleus. Anatomy and Embryology (Brain Structure and Function), 204 (2), 153-159.
  • Power, B., Mitrofanis, J. (2001). Zona Incerta: Substrate fro contralateral interconnectivity in the thalamus of rats. The Journal of Comparative Neurology, 436 (1), 52-63.

Conferences

  • Stone, J., Johnstone, D., Mitrofanis, J. (2013). The helmet experiment in Parkinson's disease: an observation of the mechanism of neuroprotection by near infra-red light. The 9th World Association for Laser Therapy Congress, Bologna, Italy: Medimond International Proceedings.

2014

  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274(C), 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Johnstone, D., Coleman, K., Moro, C., Torres, N., Eells, J., Baker, G., Ashkan, K., Stone, J., Benabid, A., Mitrofanis, J. (2014). The potential of light therapy in Parkinson's disease. ChronoPhysiology and Therapy, 4, 1-14. [More Information]

2013

  • Moro, C., Torres, N., El Massri, N., Ratel, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A. (2013). Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. BMC Neuroscience, 14(1), 1-9. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Stone, J., Johnstone, D., Mitrofanis, J. (2013). The helmet experiment in Parkinson's disease: an observation of the mechanism of neuroprotection by near infra-red light. The 9th World Association for Laser Therapy Congress, Bologna, Italy: Medimond International Proceedings.
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]

2012

  • Shaw, V., Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice. Parkinson's Disease, 2012, 1-9. [More Information]
  • Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease. Parkinsonism & Related Disorders, 18(5), 468-476. [More Information]
  • Peoples, C., Shaw, V., Stone, J., Jeffery, G., Baker, G., Mitrofanis, J. (2012). Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice. ISRN Neurology, 2012, 1-8. [More Information]

2011

  • Benabid, A., Mitrofanis, J., Chabardes, S., Seigneuret, E., Torres, N., Piallat, B., Benazzouz, A., Fraix, V., Krack, P., Pollak, P., et al (2011). Subthalamic deep brain stimulation for Parkinson's disease. In H. Richard Winn, Julian R. Youmans (Eds.), Youmans Neurological Surgery, (pp. 944-962). Philadelphia: Elsevier - Health Sciences Division.

2010

  • Shaw, V., Keay, K., Ashkan, K., Benabid, A., Mitrofanis, J. (2010). Dopaminergic cells in the periaqueductal grey matter of MPTP-treated monkeys and mice; patterns of survival and effect of deep brain stimulation and lesion of the subthalamic nucleus. Parkinsonism and Related Disorders, 16(5), 338-344. [More Information]
  • Shaw, V., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2010). Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment. The Journal of Comparative Neurology, 518(1), 25-40. [More Information]

2009

  • Benabid, A., Chabardes, S., Mitrofanis, J., Pollak, P. (2009). Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Lancet Neurology, 8(1), 67-81. [More Information]
  • Ma, J., Shaw, V., Mitrofanis, J. (2009). Does melatonin help save dopaminergic cells in MPTP-treated mice? Parkinsonism and Related Disorders, 15(4), 307-314. [More Information]

2008

  • Reyes, S., Mitrofanis, J. (2008). Patterns of FOS expression in the spinal cord and periaqueductal grey matter of 6OHDA-lesioned rats. International Journal of Neuroscience, 118(8), 1053-1079. [More Information]
  • Heise, C., Reyes, S., Mitrofanis, J. (2008). Sensory (nociceptive) stimulation evokes Fos expression in the subthalamus of hemiparkinsonian rats. Neurological research, 30(3), 277-284. [More Information]

2007

  • Luquin, N., Mitrofanis, J. (2007). Does the cerebral cortex exacerbate dopaminergic cell death in the substantia nigra of 6OHDA-lesioned rats? Parkinsonism and Related Disorders, doi:10.1016/j.parkreldis.2007.08.010(14(3)), 213-223. [More Information]
  • Ashkan, K., Wallace, B., Mitrofanis, J., Pollo, C., Brard, P., Fagret, D., Benabid, A. (2007). SPECT imaging, immunohistochemical and behavioural correlations in the primate models of Parkinson''s disease. Parkinsonism and Related Disorders, 13(5), 266-275.
  • Wallace, B., Ashkan, K., Heise, C., Foote, K., Torres, N., Mitrofanis, J., Benabid, A. (2007). Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys. Brain, 130(8), 2129-2145. [More Information]

2006

  • Heise, C., Mitrofanis, J. (2006). Fos immunoreactivity in some locomotor neural centres of 6OHDA-lesioned rats. Anatomy and Embryology (Brain Structure and Function), 211(6), 659-671. [More Information]

2005

  • Mitrofanis, J., Benabid, A., Wallace, B., Xia, R., Piallat, B., Chabardes, S., Berger, F. (2005). A putative generalized model of the effects and mechanism of action of high frequency electrical stimulation of the central nervous system. Acta neurologica Belgica, 105(3), 149-57. [More Information]
  • Heise, C., Teo, Z., Wallace, B., Ashkan, K., Benabid, A., Mitrofanis, J. (2005). Cell survival patterns in the pedunculopontine tegmental nucleus of methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys and 6OHDA-lesioned rats: evidence for differences to idiopathic Parkinson disease patients? Anatomy and Embryology (Brain Structure and Function), 210(4), 287-302. [More Information]
  • Fitzpatrick, E., Ashkan, K., Wallace, B., Benabid, A., Mitrofanis, J. (2005). Differential survival patterns among midbrain dopaminergic cells of MPTP-treated monkeys and 6OHDA-lesioned rats. Anatomy and Embryology (Brain Structure and Function), 210(2), 101-23. [More Information]
  • Heise, C., Mitrofanis, J. (2005). Reduction in parvalbumin expression in the zona incerta after 6OHDA lesion in rats. Brain Cell Biology, 34(6), 421-34. [More Information]
  • Mitrofanis, J. (2005). Some certainty for the "zone of uncertainty"? exploring the function of the zona incerta. Neuroscience, 130(1), 1-15.
  • Benabid, A., Wallace, B., Mitrofanis, J., Xia, C., Piallat, B., Fraix, V., Batir, A., Krack, P., Pollak, P., Berger, F. (2005). Therapeutic electrical stimulation of the central nervous system. Comptes Rendus de L'academie des Sciences. Biologies, 328(2), 177-186. [More Information]

2004

  • Mitrofanis, J., Ashkan, K., Wallace, B., Benabid, A. (2004). Chemoarchitectonic Heterogeneities In The Primate Zona Incerta: Clinical And Functional Implications. Brain Cell Biology, 33(4), 429-440.
  • Heise, C., Mitrofanis, J. (2004). Evidence For A Glutamatergic Projection From The Zona Incerta To The Basal Ganglia Of Rats. The Journal of Comparative Neurology, 468(4), 482-495. [More Information]

2003

  • Shaw, V., Mitrofanis, J. (2003). Anatomical eveidence for somatotopic maps in the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 11, 119-130.
  • Power, B., Mitrofanis, J. (2003). Ultrastructure of afferents from the zona incerta to the posterior and parafascicular thalamic nuclei of rats. The Journal of Comparative Neurology, 451(1), 33-44. [More Information]

2002

  • Shaw, V., Mitrofanis, J. (2002). Anatomical evidence for somatotopic maps in the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 206(1-2), 119-130. [More Information]
  • Mitrofanis, J. (2002). Distinctive patterns of connectivity between the zona incerta and the red nucleus of rats. Anatomy and Embryology (Brain Structure and Function), 205(4), 283-289. [More Information]
  • Mitrofanis, J. (2002). Evidence for an auditory subsector within the zona incerta of rats. Anatomy and Embryology (Brain Structure and Function), 205(5-6), 453-462. [More Information]

2001

  • Power, B., Leamey, C., Mitrofanis, J. (2001). Evidence for a visual subsector within the zona incerta. Visual Neuroscience, 18 (2), 179-186.
  • Kolmac, C., Mitrofanis, J. (2001). Induction of Fos-like immunoreactivity in the ventral thalamus after electrical or chemical stimulation of various subcortical centres of rats. Neuroscience Letters, 301 (3), 195-198.
  • Mitrofanis, J., DeFonseka, R. (2001). Organisation of connections between the zona incerta and the interposed nucleus. Anatomy and Embryology (Brain Structure and Function), 204 (2), 153-159.
  • Power, B., Mitrofanis, J. (2001). Zona Incerta: Substrate fro contralateral interconnectivity in the thalamus of rats. The Journal of Comparative Neurology, 436 (1), 52-63.

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