Professor John Prineas

AO
Honorary Professor
Medicine, Central Clinical School


Curriculum vitae Curriculum vitae

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Representative Publications

Prineas, J., Raine, C.S. and Wisniewski, H., “An ultrastructural study of experimental demyelination and remyelination. III. Chronic experimental allergic encephalomyelitis in the central nervous system.” Lab. Invest. 21: 472-483, 1969.

Levine, S. Prineas, J. and Scheinberg, L.C., “Allergic encephalomyelitis: inhibition of cellular passive transfer by X-irradiation” Proc. Soc. Exper. Biol. Med 131: 986-990, 1969.

Prineas, J.W., “The etiology and pathogenesis of multiple sclerosis.” In: Handbook of Clinical Neurology. Vol. 9. (Eds.) P.J.Vinken and G.W. Bruyn. North-Holland Amsterdam, 1970, pp. 107-160.

Prineas, J.W., “Acute idiopathic polyneuritis. An electron microscope study.” Lab. Invest. 26: 133-147, 1972.

Prineas, J.W. and Wright, R.G., “The fine structure of peripheral nerve lesions in a virus induced demyelinating disease in fowls (Marek’s disease).” Lab. Invest. 26: 348-557, 1972.

Prineas, J., “Paramyxovirus-like particles associated with acute demyelination in chronic relapsing multiple sclerosis.” Science 178: 760-763, 1972.

Prineas, J.W. and McLeod, J.G., “Chronic relapsing polyneuritis.” J. Neurol. Sci. 27: 427-458, 1976.

Prineas, J.W., Ouvrier, R.A., Wright, R.G., Walsh, J.C. and McLeod, J.G., “Giant axonal neuropathy – A generalized disorder of cytoplasmic microfilament formation.” J. Neuropath. Exp. Neurol. 35 (4): 458-470, 1976.

Prineas, J.W. and Wright, R.G., “Macrophages, lymphocytes and plasma cells in the perivascular compartment in chronic multiple sclerosis.” Lab. Invest. 38: 409-421, 1978.

Prineas, J.W. and Connell, F., “The fine structures of chronically active multiple sclerosis plaques.” Neurology 28 (9-2): 68-75, 1978.

Prineas, J.W. and Connell, F., “Remyelination in multiple sclerosis.” Ann. Neurol. 5: 22-31, 1979.

Prineas, J.W., “ Multiple sclerosis: Presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord.” Science 203: 1123-1125, 1979.

Dalakas, M., Wright, R.G. and Prineas, J.W., “Nature of the reversible white matter lesion in multiple sclerosis: Effects of acute inflammation on myelinated tissue studied in the rabbit eye.” Brain 103: 515-524, 1981

Prineas, J.W., “Pathology of the Guillain-Barré syndrome.” Ann. Neurol 1981; 9(suppl): 6-19.

Prineas, J.W. and Graham, J.S., “Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown.” Ann. Neurol. 10: 149-158, 1981.

Epstein, L.G., Prineas, J.W. an Raine, C.S., “Attachment of myelin to coated pits on macrophages in experimental allergic encephalomyelitis.” J. Neurol. Sci. 61: 341-348, 1983.

Prineas, J.W., Kwon, E.E., Sternberger, N.H. and Lennon, V.A., “The distribution of myelin-associated glycoprotein and myelin basic protein in actively demyelinating multiple sclerosis lesions.” J. Neuroimmunol. 6; 251-264, 1984.

Prineas, J.W., Kwon, E.E., Cho, E-S. And Sharer, L.R., “Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques.” Ann. N.Y. Acad. Sci. 436: 11-32, 1984.

Prineas, J.W., “The neuropathology of multiple sclerosis.” In: Handbook of Clinical Neurology. Vol. 3 (37), Chapter 8: Demyelinating Diseases. (Eds.) P.J.Vinken and G.W. Bruyn, North Holland, Amsterdam; American Elsevier Publishing Co., Inc., New York, 1985, pp. 213-257.

Prineas, J.W., Kwon, E.E., Goldenberg, P.Z., Ilyas, A.A., Quarles, R.H., Benjamins, J.A. and Sprinkle, T.J., “Multiple sclerosis: Oligodendrocyte proliferation and differentiation in fresh lesions.” Lab. Invest. 61: 489-503, 1989.

Goldenberg, P.Z., Troiano, R.A., Kwon, E.E. and Prineas, J.W., “Sera from MS patients and normal controls opsonize myelin.” Neurosci. Lett. 109: 353-356, 1990.

Prineas, J.W., Kwon, E.E., Goldenberg, P.Z., Cho, E-S. And Sharer, L.R., “Interaction of astrocytes and newly formed oligodendrocytes in resolving multiple sclerosis lesions.” Lab. Invest. 63: 624-636, 1990

Prineas, J.W., Barnard, R.O., Kwon, E.E., Sharer, L.R. and Cho, E-S., “Multiple sclerosis: Remyelination of nascent lesions.” Ann. Neurol. 33:137-151, 1993.

Prineas, J.W., Barnard, R.O., Revesz, T., Kwon, E.E., Sharer, L. and Cho, E-S., “Multiple sclerosis: pathology of recurrent lesions.” Brain 116: 681-693, 1993.

Kwon, E.E. and Prineas, J.W., “Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions. An immunohistochemical study.” J. Neuropath. Exp. Neurol. 534: 625-636, 1994.

Prineas JW, Kwon EE, Cho E-S, Sharer LR, Barnett MH, Oleszak EL, Hoffman, B, Morgan BP. “Immunopathology of secondary progressive multiple sclerosis.” Ann Neurol 2001 50(5):646-657

Prineas, J.W. , McDonald, W.I., and Franklin, R., “Demyelinating Diseases.” In: “Greenfield’s Neuropathology”, 7th edition ( Eds.) D.I. Graham and PL Lantos, Arnold, London, New Delhi, 2002 pp471-550.

Barnett MH and Prineas JW. “Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion”. Ann Neurol 2004 55: 458-468

Prineas JW and Barnett MH. Oligodendrocyte apoptosis before immune attack in multiple sclerosis. Reply. Ann Neurol 2005; 57: 158-159 (Letter)

Barnett MH, Cho E-S & Prineas JW. Immunoglobulins and complement in postmortem multiple sclerosis tissue. Ann Neurol 2009; 65:32-46.

Henderson APD, Barnett MH, Parratt JDE and Prineas JW Multiple sclerosis: Distribution of inflammatory cells in newly forming lesions. Ann Neurol 2009; 66: 739-753.

Parratt JDE and Prineas JW. Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes. Multiple Sclerosis 2010; 16: 1156-1172.

Prineas JW, Parratt JD. Oligodendrocytes and the early multiple sclerosis lesion. Ann Neurol 2012; 72: 18-31

Selected publications

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Journals

  • Barnett, M., Prineas, J., Buckland, M., Parratt, J., Pollard, J. (2012). Massive astrocyte destruction in neuromyelitis optica despite natalizumab therapy. Multiple Sclerosis Journal, 18(1), 108-112. [More Information]
  • Parratt, J., Prineas, J. (2012). Oligodendrocytes and the early multiple sclerosis lesion. Annals of Neurology, 72(1), 18-31. [More Information]
  • Ly, L., Barnett, M., Zheng, Y., Gulati, T., Prineas, J., Crossett, B. (2011). Comprehensive Tissue Processing Strategy for Quantitative Proteomics of Formalin-fixed Multiple Sclerosis Lesions. Journal of Proteome Research, 10(10), 4855-4868. [More Information]
  • Parratt, J., Prineas, J. (2010). Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes. Multiple Sclerosis: clinical and laboratory research, 16(10), 1156-1172. [More Information]
  • Barnett, M., Parratt, J., Cho, E., Prineas, J. (2009). Immunoglobulins and complement in postmortem multiple sclerosis tissue. Annals of Neurology, 65(1), 32-46. [More Information]
  • Barnett, M., Parratt, J., Pollard, J., Prineas, J. (2009). MS: Is it One Disease? The International M S Journal, 16(2), 57-65. [More Information]
  • Henderson, A., Barnett, M., Parratt, J., Prineas, J. (2009). Multiple sclerosis: Distribution of inflammatory cells in newly forming lesions. Annals of Neurology, 66(6), 739-753. [More Information]
  • Parratt, J., Henderson, A., Prineas, J. (2008). The cellular pathology of multiple sclerosis: Granzyme B expressing CD8-T lymphocytes predominate in demyelinated zones of acute lesions. Journal of Clinical Neuroscience, 15(3), 359-360. [More Information]
  • Barnett, M., Henderson, A., Prineas, J. (2006). The macrophage in MS: just a scavenger after all? Pathology and pathogenesis of the acute MS lesion. Multiple Sclerosis: clinical and laboratory research, 12(2), 121-132. [More Information]
  • Barnett, M., Prineas, J. (2004). Relapsing And Remitting Multiple Sclerosis: Pathology Of The Newly Forming Lesion. Annals of Neurology, 55(4), 458-468. [More Information]

Conferences

  • Patani, (., Barnett, M., Prineas, J. (2006). The pathology of impaired remyelination in multiple sclerosis. 189th Meeting of the Pathological Society of Great Britain and Ireland, United Kingdom: John Wiley & Sons.

2012

  • Barnett, M., Prineas, J., Buckland, M., Parratt, J., Pollard, J. (2012). Massive astrocyte destruction in neuromyelitis optica despite natalizumab therapy. Multiple Sclerosis Journal, 18(1), 108-112. [More Information]
  • Parratt, J., Prineas, J. (2012). Oligodendrocytes and the early multiple sclerosis lesion. Annals of Neurology, 72(1), 18-31. [More Information]

2011

  • Ly, L., Barnett, M., Zheng, Y., Gulati, T., Prineas, J., Crossett, B. (2011). Comprehensive Tissue Processing Strategy for Quantitative Proteomics of Formalin-fixed Multiple Sclerosis Lesions. Journal of Proteome Research, 10(10), 4855-4868. [More Information]

2010

  • Parratt, J., Prineas, J. (2010). Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes. Multiple Sclerosis: clinical and laboratory research, 16(10), 1156-1172. [More Information]

2009

  • Barnett, M., Parratt, J., Cho, E., Prineas, J. (2009). Immunoglobulins and complement in postmortem multiple sclerosis tissue. Annals of Neurology, 65(1), 32-46. [More Information]
  • Barnett, M., Parratt, J., Pollard, J., Prineas, J. (2009). MS: Is it One Disease? The International M S Journal, 16(2), 57-65. [More Information]
  • Henderson, A., Barnett, M., Parratt, J., Prineas, J. (2009). Multiple sclerosis: Distribution of inflammatory cells in newly forming lesions. Annals of Neurology, 66(6), 739-753. [More Information]

2008

  • Parratt, J., Henderson, A., Prineas, J. (2008). The cellular pathology of multiple sclerosis: Granzyme B expressing CD8-T lymphocytes predominate in demyelinated zones of acute lesions. Journal of Clinical Neuroscience, 15(3), 359-360. [More Information]

2006

  • Barnett, M., Henderson, A., Prineas, J. (2006). The macrophage in MS: just a scavenger after all? Pathology and pathogenesis of the acute MS lesion. Multiple Sclerosis: clinical and laboratory research, 12(2), 121-132. [More Information]
  • Patani, (., Barnett, M., Prineas, J. (2006). The pathology of impaired remyelination in multiple sclerosis. 189th Meeting of the Pathological Society of Great Britain and Ireland, United Kingdom: John Wiley & Sons.

2004

  • Barnett, M., Prineas, J. (2004). Relapsing And Remitting Multiple Sclerosis: Pathology Of The Newly Forming Lesion. Annals of Neurology, 55(4), 458-468. [More Information]

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