Professor John Wheatley

Clinical Professor
Sleep Medicine, Westmead Clinical School
Director, Ludwig Engel Centre for Respiratory Research
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 6797
Fax +61 2 9845 7286

Curriculum vitae Curriculum vitae

Map

Selected grants

2012

  • Microvascular and Macrovascular Disease in Snoring and Obstructive Sleep Apnoea: A Mechanism for Increased Stroke Risk.; Wheatley J, Lindley R, Wang J, Amis T, Kairaitis K; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • NHMRC Practitioner Fellowship 1; Wheatley J; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.
  • The impact of CPAP treatment on carotid artery atherosclerosis in heavy snoring and mild sleep disordered breathing; Wheatley J, Amis T; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • The Role of Snoring Vibrations in the Pathogenesis of Early Carotid Artery Atherosclerosis; Wheatley J, Amis T, Witting P; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Hydrostatic pressure distributions in peri-pharyngeal tissues : impact on upper airway patency; Amis T, Bilston L, Wheatley J, Bilston L, Kairaitis K; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Surface Tension of Upper Airway Lining Liquid :Role in Obstructive Sleep Apnoea Hypopnoea Syndrome; Amis T, Wheatley J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Baroreflex in Snoring and the Obstructive Sleep Apnoea Hypopnoea Syndrome; Wheatley J, Amis T; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Pressures exerted on upper airway walls by surrounding tissue structures; Amis T, Wheatley J; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Epithelial ion transport defects in cystic fibrosis: pathophysiology and treatment; Middleton P, Wheatley J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The vascular consequences of snoring and obstructive sleep apnoea; Wheatley J, Amis T; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Upper airway function in health and disease; Amis T, Wheatley J; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Kezirian, E., Goding, G., Malhotra, A., O'Donoghue, F., Zammit, G., Wheatley, J., Catcheside, P., Smith, P., Schwartz, A., Walsh, J., Palme, C., et al (2014). Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes. Journal of Sleep Research, 23(1), 77-83. [More Information]
  • Amatoury, J., Kairaitis, K., Wheatley, J., Bilston, L., Amis, T. (2014). Peri-pharyngeal tissue deformation and stress distributions in response to caudal tracheal displacement: Pivotal influence of the hyoid bone? Journal of Applied Physiology, 116(7), 746-756. [More Information]
  • Gehring, J., Cho, J., Wheatley, J., Amis, T. (2014). Response characteristics for thermal and pressure devices commonly used for monitoring nasal and oral airflow during sleep studies. Physiological measurement, 35(3), 455-470. [More Information]
  • Perri, R., Kairaitis, K., Cistulli, P., Wheatley, J., Amis, T. (2014). Surface cephalometric and anthropometric variables in osa patients: statistical models for the osa phenotype. Sleep and Breathing, 18(1), 39-52. [More Information]
  • Norman, M., Middleton, S., Erskine, O., Middleton, P., Wheatley, J., Sullivan, C. (2014). Validation of the sonomat: a contactless monitoring system used for the diagnosis of sleep disordered breathing. Sleep, 37(9), 1477-1487. [More Information]
  • Narayan, J., Amatoury, J., Verma, M., Kairaitis, K., Wheatley, J., Amis, T. (2013). Resetting the baroreflex during snoring: Role of resistive loading and intra-thoracic pressure. Respiratory Physiology and Neurobiology, 185(3), 489-496. [More Information]
  • Kairaitis, K., Amatoury, J., Wheatley, J., Amis, T. (2013). The upper airway’s next top model? Letter to the Editor in response to CrossTalk: The human upper airway does/does not behave like a Starling resistor during sleep. Journal of Physiology-Paris, 2013, 1-2.
  • Kairaitis, K., Verma, M., Amatoury, J., Wheatley, J., White, D., Amis, T. (2012). A threshold lung volume for optimal mechanical effects on upper airway airflow dynamics: studies in an anesthetized rabbit model. Journal of Applied Physiology, 112(7), 1197-1205. [More Information]
  • Narayan, J., Amatoury, J., Cho, J., Verma, M., Kairaitis, K., Wheatley, J., Amis, T. (2012). Snoring effects on the baroreflex: An animal model. Respiratory Physiology and Neurobiology, 180(2-3), 342-351. [More Information]
  • Teo, M., Amis, T., Lee, S., Falland, K., Lambert, S., Wheatley, J. (2011). Equivalence of nasal and oronasal masks during initial CPAP titration for obstructive sleep apnea syndrome. Sleep, 34(7), 951-955. [More Information]
  • Kirkness, J., Verma, M., McGinley, B., Erlacher, M., Schwartz, A., Smith, P., Wheatley, J., Patil, S., Amis, T., Schneider, H. (2011). Pitot-tube flowmeter for quantification of airflow during sleep. Physiological Measurement, 32(2), 223-237. [More Information]
  • Cho, J., Witting, P., Verma, M., Wu, B., Shanu, A., Kairaitis, K., Amis, T., Wheatley, J. (2011). Tissue Vibration Induces Carotid Artery Endothelial Dysfunction: A Mechanism Linking Snoring and Carotid Atherosclerosis? Sleep, 34(6), 751-757C. [More Information]
  • Eastwood, P., Barnes, M., Walsh, J., Maddison, K., Hee, G., Schwartz, A., Smith, P., Malhotra, A., McEvoy, R., Wheatley, J., et al (2011). Treating Obstructive Sleep Apnea with Hypoglossal Nerve Stimulation. Sleep, 34(11), 1479-1486C. [More Information]
  • Amatoury, J., Kairaitis, K., Wheatley, J., Bilston, L., Amis, T. (2010). Onset of Airflow Limitation in a Collapsible Tube Model: Impact of Surrounding Pressure, Longitudinal Strain and Wall Folding Geometry. Journal of Applied Physiology, 109(5), 1467-1475. [More Information]
  • Cho, J., Wheatley, J. (2010). The association of carotid artery disease with snoring and obstructive sleep apnoea: definitions,pathogenesis and treatment. Australasian Journal of Ultrasound in Medicine, 13(1), 27-31.
  • Kairaitis, K., Howitt, L., Wheatley, J., Amis, T. (2009). Mass loading of the upper airway extraluminal tissue space in rabbits: effects on tissue pressure and pharyngeal airway lumen geometry. Journal of Applied Physiology, 106(3), 887-892. [More Information]
  • Kairaitis, K., Verma, M., Fish, V., Wheatley, J., Amis, T. (2009). Pharyngeal muscle contraction modifies peri-pharyngeal tissue pressure in rabbits. Respiratory Physiology and Neurobiology, 166(2), 95-101. [More Information]
  • Hallani, M., Wheatley, J., Amis, T. (2008). Enforced mouth breathing decreases lung function in mild asthmatics. Respirology, 13(4), 553-558. [More Information]
  • Lee, S., Amis, T., Byth Wilson, K., Larcos, G., Kairaitis, K., Robinson, T., Wheatley, J. (2008). Heavy snoring as a cause of carotid artery atherosclerosis. Sleep, 31(9), 1207-1213. [More Information]
  • Hallani, M., Wheatley, J., Amis, T. (2008). Initiating oral breathing in response to nasal loading: asthmatics versus healthy subjects. European Respiratory Journal, 31, 800-806. [More Information]
  • Lam, J., Kairaitis, K., Verma, M., Wheatley, J., Amis, T. (2008). Saliva production and surface tension: influences on patency of the passive upper airway. The Journal of Physiology, 586(22), 5537-5547. [More Information]
  • Howitt, L., Kairaitis, K., Kirkness, J., Garlick, S., Wheatley, J., Byth, K., Amis, T. (2007). Oscillatory Pressure Wave Transmission from the Upper Airway to the Carotid Artery. Journal of Applied Physiology, 103(5), 1622-1627. [More Information]
  • Marshall, N., Wilsmore, B., McEvoy, R., Wheatley, J., Dodd, M., Grunstein, R. (2007). Polysomnography in Australia- Trends in Provision. The Journal of Clinical Sleep Medicine, 3(3), 281-284. [More Information]
  • Kairaitis, K., Byth Wilson, K., Parikh, R., Stavrinou, R., Wheatley, J., Amis, T. (2007). Tracheal Traction Effects on Upper Airway Patency in Rabbits: The Role of Tissue Pressure. Sleep, 30(2), 179-186. [More Information]
  • Verma, M., Seto-Poon, M., Wheatley, J., Amis, T., Kirkness, J. (2006). Influence of breathing route on upper airway lining liquid surface tension. The Journal of Physiology, 574, 859-866. [More Information]
  • Kairaitis, K., Stavrinou, R., Parikh, R., Wheatley, J., Amis, T. (2006). Mandibular advancement decreases pressures in the tissues surrounding the upper airway in rabbits. Journal of Applied Physiology, 100(1), 349-356. [More Information]
  • Amatoury, J., Howitt, L., Wheatley, J., Avolio, A., Amis, T. (2006). Snoring-related energy transmission to the carotid artery in rabbits. Journal of Applied Physiology, 100(5), 1547-1553. [More Information]
  • Kirkness, J., Christenson, H., Wheatley, J., Amis, T. (2005). Application of the 'pull-off' force method for measurement of surface tension of upper airway mucosal lining liquid. Physiological Measurement, 26(5), 677-688. [More Information]
  • Britton, W., Gilbert, G., Wheatley, J., Leslie, D., Rothel, J., Jones, S., Bradley, P. (2005). Sensitivity of human gamma interferon assay and tuberculin skin testing for detecting infection with Mycobacterium tuberculosis in patients with culture positive tuberculosis. Tuberculosis, 85(3), 137-145. [More Information]
  • Kirkness, J., Madronio, C., Stavrinou, R., Wheatley, J., Amis, T. (2005). Surface tension of upper airway mucosal lining liquid in obstructive sleep apnea/hypopnea syndrome. Sleep, 28(4), 457-463. [More Information]
  • Jenkins, C., Thien, N., Wheatley, J., Reddel, H. (2005). Traditional and patient-centred outcomes with three classes of asthma medication. European Respiratory Journal, 26(1), 36-44. [More Information]
  • Flemons, W., Douglas, N., Kuna, S., Rodenstein, D., Wheatley, J. (2004). Access to Diagnosis And Treatment Of Patients With Suspected Sleep Apnea. American Journal of Respiratory and Critical Care Medicine, 169(6), 668-672.
  • Madronio, M., Somma, E., Stavrinou, R., Kirkness, J., Goldfinch, E., Wheatley, J., Amis, T. (2004). Older Individuals Have Increased Oro-Nasal Breathing During Sleep. European Respiratory Journal, 24(1), 71-77.
  • Middleton, P., Pollard, K., Donohoo, E., Wheatley, J., Geddes, D., Alton, E. (2003). Airway surface liquid calcium modulates chloride permeability in the cystic fibrosis airway. American Journal of Respiratory and Critical Care Medicine, 168(10), 1223-1226.
  • Kirkness, J., Christenson, H., Garlick, S., Parikh, R., Kairaitis, K., Wheatley, J., Amis, T. (2003). Decreased surface tension of upper airway mucosal lining liquid increases upper airway patency in anaesthetised rabbits. The Journal of Physiology, 547(2), 603-611.
  • Kirkness, J., Eastwood, P., Szollosi, I., Platt, P., Wheatley, J., Amis, T., Hillman, D. (2003). Effect of surface tension of mucosal lining liquid on upper airway mechanics in anesthetized humans. Journal of Applied Physiology, 95, 357-363.
  • Desai, A., Ellis, E., Wheatley, J., Grunstein, R. (2003). Fatal distraction: a case series of fatal fall-asleep road accidents and their medicolegal outcomes. Medical Journal of Australia, 178(8), 396-399.
  • Kirkness, J., Madronio, M., Stavrinou, R., Wheatley, J., Amis, T. (2003). Relationship between surface tension of upper airway lining liquid and upper airway collapsibility during sleep in obstructive sleep apnea hypopnea syndrome. Journal of Applied Physiology, 95(5), 1761-1766.
  • Kairaitis, L., Parikh, R., Stavrinou, R., Garlick, S., Kirkness, J., Wheatley, J., Amis, T. (2003). Upper airway extraluminal tissue pressure fluctuations during breathing in rabbits. Journal of Applied Physiology, 95(4), 1560-1566.

Conferences

  • Kirkness, J., Verma, M., Maly, J., Wheatley, J., Amis, T., Smith, P., Schwartz, A., Schneider, H. (2006). Quantification of inspiratory airflow obstruction using a novel light-weight flowmeter. SLEEP, the 20th Annual Meeting of the Associated Professional Sleep Societies LLC (APSS) 2006, United States: The American Academy of Sleep Medicine.

2014

  • Kezirian, E., Goding, G., Malhotra, A., O'Donoghue, F., Zammit, G., Wheatley, J., Catcheside, P., Smith, P., Schwartz, A., Walsh, J., Palme, C., et al (2014). Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes. Journal of Sleep Research, 23(1), 77-83. [More Information]
  • Amatoury, J., Kairaitis, K., Wheatley, J., Bilston, L., Amis, T. (2014). Peri-pharyngeal tissue deformation and stress distributions in response to caudal tracheal displacement: Pivotal influence of the hyoid bone? Journal of Applied Physiology, 116(7), 746-756. [More Information]
  • Gehring, J., Cho, J., Wheatley, J., Amis, T. (2014). Response characteristics for thermal and pressure devices commonly used for monitoring nasal and oral airflow during sleep studies. Physiological measurement, 35(3), 455-470. [More Information]
  • Perri, R., Kairaitis, K., Cistulli, P., Wheatley, J., Amis, T. (2014). Surface cephalometric and anthropometric variables in osa patients: statistical models for the osa phenotype. Sleep and Breathing, 18(1), 39-52. [More Information]
  • Norman, M., Middleton, S., Erskine, O., Middleton, P., Wheatley, J., Sullivan, C. (2014). Validation of the sonomat: a contactless monitoring system used for the diagnosis of sleep disordered breathing. Sleep, 37(9), 1477-1487. [More Information]

2013

  • Narayan, J., Amatoury, J., Verma, M., Kairaitis, K., Wheatley, J., Amis, T. (2013). Resetting the baroreflex during snoring: Role of resistive loading and intra-thoracic pressure. Respiratory Physiology and Neurobiology, 185(3), 489-496. [More Information]
  • Kairaitis, K., Amatoury, J., Wheatley, J., Amis, T. (2013). The upper airway’s next top model? Letter to the Editor in response to CrossTalk: The human upper airway does/does not behave like a Starling resistor during sleep. Journal of Physiology-Paris, 2013, 1-2.

2012

  • Kairaitis, K., Verma, M., Amatoury, J., Wheatley, J., White, D., Amis, T. (2012). A threshold lung volume for optimal mechanical effects on upper airway airflow dynamics: studies in an anesthetized rabbit model. Journal of Applied Physiology, 112(7), 1197-1205. [More Information]
  • Narayan, J., Amatoury, J., Cho, J., Verma, M., Kairaitis, K., Wheatley, J., Amis, T. (2012). Snoring effects on the baroreflex: An animal model. Respiratory Physiology and Neurobiology, 180(2-3), 342-351. [More Information]

2011

  • Teo, M., Amis, T., Lee, S., Falland, K., Lambert, S., Wheatley, J. (2011). Equivalence of nasal and oronasal masks during initial CPAP titration for obstructive sleep apnea syndrome. Sleep, 34(7), 951-955. [More Information]
  • Kirkness, J., Verma, M., McGinley, B., Erlacher, M., Schwartz, A., Smith, P., Wheatley, J., Patil, S., Amis, T., Schneider, H. (2011). Pitot-tube flowmeter for quantification of airflow during sleep. Physiological Measurement, 32(2), 223-237. [More Information]
  • Cho, J., Witting, P., Verma, M., Wu, B., Shanu, A., Kairaitis, K., Amis, T., Wheatley, J. (2011). Tissue Vibration Induces Carotid Artery Endothelial Dysfunction: A Mechanism Linking Snoring and Carotid Atherosclerosis? Sleep, 34(6), 751-757C. [More Information]
  • Eastwood, P., Barnes, M., Walsh, J., Maddison, K., Hee, G., Schwartz, A., Smith, P., Malhotra, A., McEvoy, R., Wheatley, J., et al (2011). Treating Obstructive Sleep Apnea with Hypoglossal Nerve Stimulation. Sleep, 34(11), 1479-1486C. [More Information]

2010

  • Amatoury, J., Kairaitis, K., Wheatley, J., Bilston, L., Amis, T. (2010). Onset of Airflow Limitation in a Collapsible Tube Model: Impact of Surrounding Pressure, Longitudinal Strain and Wall Folding Geometry. Journal of Applied Physiology, 109(5), 1467-1475. [More Information]
  • Cho, J., Wheatley, J. (2010). The association of carotid artery disease with snoring and obstructive sleep apnoea: definitions,pathogenesis and treatment. Australasian Journal of Ultrasound in Medicine, 13(1), 27-31.

2009

  • Kairaitis, K., Howitt, L., Wheatley, J., Amis, T. (2009). Mass loading of the upper airway extraluminal tissue space in rabbits: effects on tissue pressure and pharyngeal airway lumen geometry. Journal of Applied Physiology, 106(3), 887-892. [More Information]
  • Kairaitis, K., Verma, M., Fish, V., Wheatley, J., Amis, T. (2009). Pharyngeal muscle contraction modifies peri-pharyngeal tissue pressure in rabbits. Respiratory Physiology and Neurobiology, 166(2), 95-101. [More Information]

2008

  • Hallani, M., Wheatley, J., Amis, T. (2008). Enforced mouth breathing decreases lung function in mild asthmatics. Respirology, 13(4), 553-558. [More Information]
  • Lee, S., Amis, T., Byth Wilson, K., Larcos, G., Kairaitis, K., Robinson, T., Wheatley, J. (2008). Heavy snoring as a cause of carotid artery atherosclerosis. Sleep, 31(9), 1207-1213. [More Information]
  • Hallani, M., Wheatley, J., Amis, T. (2008). Initiating oral breathing in response to nasal loading: asthmatics versus healthy subjects. European Respiratory Journal, 31, 800-806. [More Information]
  • Lam, J., Kairaitis, K., Verma, M., Wheatley, J., Amis, T. (2008). Saliva production and surface tension: influences on patency of the passive upper airway. The Journal of Physiology, 586(22), 5537-5547. [More Information]

2007

  • Howitt, L., Kairaitis, K., Kirkness, J., Garlick, S., Wheatley, J., Byth, K., Amis, T. (2007). Oscillatory Pressure Wave Transmission from the Upper Airway to the Carotid Artery. Journal of Applied Physiology, 103(5), 1622-1627. [More Information]
  • Marshall, N., Wilsmore, B., McEvoy, R., Wheatley, J., Dodd, M., Grunstein, R. (2007). Polysomnography in Australia- Trends in Provision. The Journal of Clinical Sleep Medicine, 3(3), 281-284. [More Information]
  • Kairaitis, K., Byth Wilson, K., Parikh, R., Stavrinou, R., Wheatley, J., Amis, T. (2007). Tracheal Traction Effects on Upper Airway Patency in Rabbits: The Role of Tissue Pressure. Sleep, 30(2), 179-186. [More Information]

2006

  • Verma, M., Seto-Poon, M., Wheatley, J., Amis, T., Kirkness, J. (2006). Influence of breathing route on upper airway lining liquid surface tension. The Journal of Physiology, 574, 859-866. [More Information]
  • Kairaitis, K., Stavrinou, R., Parikh, R., Wheatley, J., Amis, T. (2006). Mandibular advancement decreases pressures in the tissues surrounding the upper airway in rabbits. Journal of Applied Physiology, 100(1), 349-356. [More Information]
  • Kirkness, J., Verma, M., Maly, J., Wheatley, J., Amis, T., Smith, P., Schwartz, A., Schneider, H. (2006). Quantification of inspiratory airflow obstruction using a novel light-weight flowmeter. SLEEP, the 20th Annual Meeting of the Associated Professional Sleep Societies LLC (APSS) 2006, United States: The American Academy of Sleep Medicine.
  • Amatoury, J., Howitt, L., Wheatley, J., Avolio, A., Amis, T. (2006). Snoring-related energy transmission to the carotid artery in rabbits. Journal of Applied Physiology, 100(5), 1547-1553. [More Information]

2005

  • Kirkness, J., Christenson, H., Wheatley, J., Amis, T. (2005). Application of the 'pull-off' force method for measurement of surface tension of upper airway mucosal lining liquid. Physiological Measurement, 26(5), 677-688. [More Information]
  • Britton, W., Gilbert, G., Wheatley, J., Leslie, D., Rothel, J., Jones, S., Bradley, P. (2005). Sensitivity of human gamma interferon assay and tuberculin skin testing for detecting infection with Mycobacterium tuberculosis in patients with culture positive tuberculosis. Tuberculosis, 85(3), 137-145. [More Information]
  • Kirkness, J., Madronio, C., Stavrinou, R., Wheatley, J., Amis, T. (2005). Surface tension of upper airway mucosal lining liquid in obstructive sleep apnea/hypopnea syndrome. Sleep, 28(4), 457-463. [More Information]
  • Jenkins, C., Thien, N., Wheatley, J., Reddel, H. (2005). Traditional and patient-centred outcomes with three classes of asthma medication. European Respiratory Journal, 26(1), 36-44. [More Information]

2004

  • Flemons, W., Douglas, N., Kuna, S., Rodenstein, D., Wheatley, J. (2004). Access to Diagnosis And Treatment Of Patients With Suspected Sleep Apnea. American Journal of Respiratory and Critical Care Medicine, 169(6), 668-672.
  • Madronio, M., Somma, E., Stavrinou, R., Kirkness, J., Goldfinch, E., Wheatley, J., Amis, T. (2004). Older Individuals Have Increased Oro-Nasal Breathing During Sleep. European Respiratory Journal, 24(1), 71-77.

2003

  • Middleton, P., Pollard, K., Donohoo, E., Wheatley, J., Geddes, D., Alton, E. (2003). Airway surface liquid calcium modulates chloride permeability in the cystic fibrosis airway. American Journal of Respiratory and Critical Care Medicine, 168(10), 1223-1226.
  • Kirkness, J., Christenson, H., Garlick, S., Parikh, R., Kairaitis, K., Wheatley, J., Amis, T. (2003). Decreased surface tension of upper airway mucosal lining liquid increases upper airway patency in anaesthetised rabbits. The Journal of Physiology, 547(2), 603-611.
  • Kirkness, J., Eastwood, P., Szollosi, I., Platt, P., Wheatley, J., Amis, T., Hillman, D. (2003). Effect of surface tension of mucosal lining liquid on upper airway mechanics in anesthetized humans. Journal of Applied Physiology, 95, 357-363.
  • Desai, A., Ellis, E., Wheatley, J., Grunstein, R. (2003). Fatal distraction: a case series of fatal fall-asleep road accidents and their medicolegal outcomes. Medical Journal of Australia, 178(8), 396-399.
  • Kirkness, J., Madronio, M., Stavrinou, R., Wheatley, J., Amis, T. (2003). Relationship between surface tension of upper airway lining liquid and upper airway collapsibility during sleep in obstructive sleep apnea hypopnea syndrome. Journal of Applied Physiology, 95(5), 1761-1766.
  • Kairaitis, L., Parikh, R., Stavrinou, R., Garlick, S., Kirkness, J., Wheatley, J., Amis, T. (2003). Upper airway extraluminal tissue pressure fluctuations during breathing in rabbits. Journal of Applied Physiology, 95(4), 1560-1566.

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