Professor Jonathan Stone

Professor
Physiology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 4740

Map

International links

Israel

(Hebrew University of Jerusalem) An active collaboration with Prof. Eli Keshet on the role of cerebrovascular degeneration in causing the pathology of senile plaques.

Italy

(University of L''''Aquila) An experimental collaboration pioneering the use of antioxidants to mitigate neurodegeneration. With Professor Silvia Bisti

United States

(University of Madison Milwaukee) Experimental collaboration on the effectiveness of photobiomodulation in mitigating neuronal degenerations.With Professor Janis Eells

Selected grants

2014

  • Protection against Parkinsons disease using remote photobiomodulation: understanding mechanisms; Johnstone D, Stone J, Mitrofanis J; Brain Foundation of Australia/Annual Research Awards.
  • QuantStudio 12K Flex OpenArray System - Ramaciotti Equiment Grant 2014; Stone J; Clive and Vera Ramaciotti Foundations/Awards for Biomedical Research: Major Equipment.
  • Stereotaxic frame; Arnold J, Christie M, Collins M, Sawatari A, Leamey C, Stone J, van Nieuwenhuijzen P, Chan-Ling T, Balle T; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • La Vision BioTec Ultramicroscope; Murphy C, Braet F, Byrne M, Chan-Ling T, Fraser S, Goldsbury C, Halliday G, Hambly B, Johnstone D, Keay K, Lovelace M, Lyons G, Mason R, Overall R, Owens T, Richardson D, Stone J, Weiss A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Mouse behavioural phenotyping battery; Hunt N, Christie M, McGregor I, Kassiou M, Collins M, Stone J, Arnold J, Sawatari A, Mitrofanis J, Camp A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • A high-throughput, bright-field and fluorescence digital slide scanning platform and service that is both research and teaching-focused and available University-wide.; King N, Graeber M, Naylor M, Slapeta J, Quinnell R, Charles (nee Slaviero) K, Owens T, Bourne R, Braet F, Hambly B, Overall R, Stone J, Twigg S, Hardikar A, Halliday G, Richardson D, Byrne M, Keay K, Marsh D, Howell V, Pollock C, Chen X; DVC Research/Equipment Grant.
  • Delivering neuroprotection for older Australians; Stone J; Lord Mayors Charitable Foundation/Eldon and Anne Foote Trust.

2011

  • xCELLigence Real Time Cell Monitoring System for shared use in the Bosch Biomedical Research Community; Stone J; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Finding saffron: an initiativeto imrove the quality of life for senior Australians; Stone J; Lord Mayors Charitable Foundation/Research Grant.

2009

  • How senile plaques form in the aging and demented brain: The roles of haemorrhage and macrophages; Stone J, Keshet E; Sir Zelman Cowen Universities Fund/Grants-in-Aid.

2008

  • Sir Zelman Cowen Universities Fund Grant-in-Aid; Stone J; Sir Zelman Cowen Universities Fund/Grants-in-Aid.

2004

  • Mechanisms of cell death and rescue in photoreceptor dystrophies; Stone J, Maslim J; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Oxygen metabolism and therapy in the P23H rat model of photoreceptor degeneration; Stone J; Retina Australia Incorporated/Research Support.

2000

  • Physiological regulation of retinal trophic factors and photoreceptor vulnerability; Stone J; Retina Australia Incorporated/Research Support.
  • Perinatal stress in simplex retinitis pigmentosa; Stone J; Retina Australia Incorporated/Research Support.
  • Approaches to therapy of photoreceptor dystrophies; Stone J; Retina Australia Incorporated/Project Support.
  • Control of hypoxia in retinopathy of prematurity: a basis for intervention; Chan-Ling T, Stone J; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.
  • Developmental biology of retinal astroccytes; Stone J, Chan-Ling T, Tout S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Chrysostomou, V., Stone, J., Valter, K. (2010). Differences in Photoreceptor Sensitivity to Oxygen Stress Between Long Evans and Sprague-Dawley Rats. In Robert Anderson, Matthew LaVail, Joe Hollyfield (Eds.), Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations, (pp. 473-479). New York: Springer Science + Business Media.
  • Zhu, Y., Natoli, R., Valter, K., Stone, J. (2010). Microarray Analysis of Hyperoxia Stressed Mouse Retina: Differential Gene Expression in the Inferior and Superior Region. In Robert Anderson, Matthew LaVail, Joe Hollyfield (Eds.), Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations, (pp. 217-222). New York: Springer Science + Business Media.
  • Stone, J., Heckenlively, J. (2009). Animal models of inherited retinal degenerations. In Binder MD, Hirokawa N, Windhorst U, Hirsch M. (Eds.), Encyclopedia of Neuroscience, (pp. 437-447). New York: Springer.
  • Stone, J., Valter, K. (2008). Roles of Oxygen in the Stability of Photoreceptors: Evidence from Mouse and Other Models of Human Disease. In Chalupa L; Williams R (Eds.), Eye, Retina, and Visual System of the Mouse, (pp. 559-572). Cambridge, Massachusetts: MIT Press.
  • Stone, J., Sandercoe, T., Provis, J. (2006). Mechanisms of the Formation and Stability of Retinal Blood Vessels. In Joyce Tombran-Tink and Colin J. Barnstable (Eds.), Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics, (pp. 101-126). United States: Humana Press.
  • Geller, S., Krowka, R., Valter-Kocsi, K., Stone, J. (2006). Toxicity of Hyperoxia to the Retina: Evidence from the Mouse. In Joe G. Hollyfield, Richard E. Anderson, Matthew M. Lavail (Eds.), Advances in Experimental Medicine and Biology: Retinal Degenerative Diseases, (pp. 425-437). United States: Springer.
  • Stone, J., Mervin, K., Penfold, P., Walsh, N., Provis, J., Valter-Kocsi, K. (2005). Photoreceptor stability and degeneration in mammalian retina: lesson from the edge. In Penfold P; Provis J (Eds.), Macular Degeneration, (pp. 149-165). Germany: Springer.
  • Bravo Nuevo, A., Williams, N., Geller, S., Stone, J. (2003). Mitochondrial deletions in normal and degenerating rat retina. In Matthew M. Lavail, Joe G. Hollyfield, Robert E. Anderson (Eds.), Retinal Degenerations: Mechanisms and Experimental Therapy, (pp. 241-248). NY: Springer.
  • Lee, D., Geller, S., Walsh, N., Valter-Kocsi, K., Stone, J., Yasumura, D., Matthes, M., La Vail, M. (2003). Photoreceptor Degeneration in PRO23HIS and S334TER Transgenic Rats. In Matthew M. Lavail, Joe G. Hollyfield, Robert E. Anderson (Eds.), Retinal Degenerations: Mechanisms and Experimental Therapy, (pp. 297-302). NY: Springer.
  • Geller, S., Stone, J. (2003). Quantiative PCR analysis of FosB mRNA expression afger short duration oxygen and light stress. In Matthew M. Lavail, Joe G. Hollyfield, Robert E. Anderson (Eds.), Retinal Degenerations: Mechanisms and Experimental Therapy, (pp. 249-258). NY: Springer.
  • Stone, J., Fisher, S., Rex, T., Linberg, K., Lewis, G. (2001). Experimental retinal detachment: a paradigm for understanding the effects of induced photoreceptor degeneration. In H Kolb, H Ripps, S Wu (Eds.), Concepts and Challenges in Retinal Biology, (pp. 679-698). United States: Elsevier.
  • Walsh, N., Stone, J. (2001). Timecourse of bFGF and CNTF expression in light-induced photoreceptor degeneration in the rat retina. In Robert E Anderson, Matthew M LaVail, Joe G Hollyfield (Eds.), New Insights into Retinal Degenerative Diseases, (pp. 111-118). New York USA: Academic Press.

Journals

  • Di Marco, F., Di Paolo, M., Romeo, S., Colecchi, L., Fiorani, L., Spana, S., Stone, J., Bisti, S. (2014). Combining Neuroprotectants in a Model of Retinal Degeneration: No Additive Benefit. PloS One, 9(6), e100389. [More Information]
  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274(C), 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Brandli, A., Stone, J. (2014). Remote Ischemia Influences the Responsiveness of the Retina: Observations in the Rat. Investigative Ophthalmology & Visual Science, 55(4), 2088-2096. [More Information]
  • Johnstone, D., Coleman, K., Moro, C., Torres, N., Eells, J., Baker, G., Ashkan, K., Stone, J., Benabid, A., Mitrofanis, J. (2014). The potential of light therapy in Parkinson's disease. ChronoPhysiology and Therapy, 4, 1-14. [More Information]
  • Stone, J., De La Torre, J. (2013). Alzheimer's disease is associated with increased risk of haemorrhagic stroke. Evidence-Based Mental Health, 16(3), 88. [More Information]
  • Moro, C., Torres, N., El Massri, N., Ratel, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A. (2013). Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. BMC Neuroscience, 14(1), 1-9. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]
  • Purushothuman, S., Marotte, L., Stowe, S., Johnstone, D., Stone, J. (2013). The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model. PloS One, 8(3), 1-18. [More Information]
  • Di Marco, F., Romeo, S., Nandasena, S., Purushothuman, S., Adams, C., Bisti, S., Stone, J. (2013). The time course of action of two neuroprotectants, dietary saffron and photobiomodulation, assessed in the rat retina. American Journal of Neurodegenerative Disease, 2(3), 208-220.
  • Shaw, V., Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice. Parkinson's Disease, 2012, 1-9. [More Information]
  • Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease. Parkinsonism & Related Disorders, 18(5), 468-476. [More Information]
  • Peoples, C., Shaw, V., Stone, J., Jeffery, G., Baker, G., Mitrofanis, J. (2012). Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice. ISRN Neurology, 2012, 1-8. [More Information]
  • Natoli, R., Valter, K., Chrysostomou, V., Stone, J., Provis, J. (2011). Morphological, functional and gene expression analysis of the hyperoxic mouse retina. Experimental Eye Research, 92(4), 306-314. [More Information]
  • Zhu, Y., Natoli, R., Valter, K., Stone, J. (2010). Differential gene expression in mouse retina related to regional differences in vulnerability to hyperoxia. Molecular Vision, 16, 740-755. [More Information]
  • Zhu, Y., Valter, K., Stone, J. (2010). Environmental Damage to the Retina and Preconditioning: Contrasting Effects of Light and Hyperoxic Stress. Investigative Ophthalmology and Visual Science, 51(9), 4821-4830. [More Information]
  • Natoli, R., Zhu, Y., Valter, K., Bisti, S., Stone, J., Ellis, J. (2010). Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina. Molecular Vision, 16, 1801-1822. [More Information]
  • Shaw, V., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2010). Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment. The Journal of Comparative Neurology, 518(1), 25-40. [More Information]
  • Chrysostomou, V., Valter, K., Stone, J. (2009). Cone-rod dependence in the rat retina: variation with the rate of rod damage. Investigative Ophthalmology and Visual Science, 50(6), 3017-3023. [More Information]
  • Chrysostomou, V., Stone, J., Valter, K. (2009). Life history of cones in the rhodopsin-mutant P23H-3 rat: evidence of long-term survival. Investigative Ophthalmology and Visual Science, 50(5), 2407-2416. [More Information]
  • Valter, K., Kirk, D., Stone, J. (2009). Optimising the structure and function of the adult P23H-3 retina by light management in the juvenile and adult. Experimental Eye Research, 89(6), 1003-1011. [More Information]
  • Natoli, R., Provis, J., Valter, K., Stone, J. (2008). Expression and Role of the Early-Response Gene Oxrl in the Hyperoxia-Challenged Mouse Retina. Investigative Ophthalmology and Visual Science, 49(10), 4561-4567. [More Information]
  • Natoli, R., Provis, J., Valter, K., Stone, J. (2008). Gene regulation induced in the C57BL/6J mouse retina by hyperoxia: a temporal microarray study. Molecular Vision, 14, 1983-1994. [More Information]
  • Stone, J. (2008). Into a Maelstrom: One Man's Arrival in Mid-20th Century Australia. National Library of Australia News, 19, 18-21.
  • Eells, J., DeSmet, K., Kirk, D., Wong-Riley, M., Whelan, H., Ver Hoeve, J., Nork, T., Stone, J., Valter-Kocsi, K. (2008). Photobiomodulation for the Treatment of Retinal Injury and Retinal Degenerative Diseases. Lecture Notes in Electrical Engineering, 12, 39-51.
  • Stone, J., Van Driel, D., Valter, K., Rees, S., Provis, J. (2008). The locations of mitochondria in mammalian photoreceptors: Relation to retinal vasculature. Brain Research, 1189, 58-69. [More Information]
  • Valter, K., Kirk, D., Stone, J. (2008). The potential of ambient light restriction to restore function to the degenerating P23H-3 rat retina. Advances in Experimental Medicine and Biology, 613, 193-199. [More Information]
  • Chrysostomou, V., Stone, J., Stowe, S., Barnett, N., Valter-Kocsi, K. (2008). The status of cones in the rhodopsin mutant P23H-3 retina: Light-regulated damage and repair in parallel with rods. Investigative Ophthalmology and Visual Science, 49(3), 1116-1125. [More Information]
  • Stone, J. (2008). What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages. Medical Hypotheses, 71(3), 347-359. [More Information]
  • Bravo Nuevo, A., Williams, N., Valter-Kocsi, K., Stone, J. (2007). Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains. Mitochondrion, 7(5), 340-346. [More Information]
  • Cullen, K., Kócsi, Z., Stone, J. (2006). Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1786-1796. [More Information]
  • Cullen, K., Kocsi, Z., Stone, J. (2006). Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1786-1796.
  • Jozwick, C., Valter-Kocsi, K., Stone, J. (2006). Reversal of functional loss in the P23H-3 rat retina by management of ambient light. Experimental Eye Research, 83(5), 1074-1080. [More Information]
  • Cullen, K., Kocsi, Z., Stone, J. (2005). Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. Journal of Cerebral Blood Flow and Metabolism, 25(12), 1656-1667. [More Information]
  • Wellard, J., Lee, D., Valter-Kocsi, K., Stone, J. (2005). Photoreceptors in the rat retina are specifically vulnerable to both hypoxia and hyperoxia. Visual Neuroscience, 22(4), 501-507. [More Information]
  • Valter-Kocsi, K., Bisti, S., Gargini, C., Di Loreto, S., Maccarone, R., Cervetto, L., Stone, J. (2005). Time course of neurotrophic factor upregulation and retinal protection against light-induced damage after optic nerve section. Investigative Ophthalmology and Visual Science, 46(5), 1748-1754. [More Information]
  • Geller, S., Krowka, R., Valter-Kocsi, K., Stone, J. (2005). Toxicity of hyperoxia to the retina: Evidence from the mouse. Advances in Experimental Medicine and Biology, 572(Chapter 60), 425-437. [More Information]
  • Gragini, C., Bisti, S., Demontis, G., Valter-Kocsi, K., Stone, J., Cervetto, L. (2004). Electroretinogram Changes Associated With Retinal Upregulation Of Trophic Factors: Observations Following Optic Nerve Section. Neuroscience, 126(3), 775-783.
  • Walsh, N., Van Driel, D., Lee, D., Stone, J. (2004). Multiple Vulnerability Of Photoreceptors To Mesopic Ambient Light In The P23H Transgenic Rat. Brain Research, 1013 (2), 194-203. [More Information]
  • Yu, D., Cringle, S., Valter-Kocsi, K., Walsh, N., Lee, D., Stone, J. (2004). Photoreceptor Death, Trophic Factor Expression, Retinal Oxygen Status, And Photoreceptor Function In The P23H Rat. Investigative Ophthalmology and Visual Science, 45(6), 2013-2019.
  • Bravo Nuevo, A., Walsh, N., Stone, J. (2004). Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse. Investigative Ophthalmology and Visual Science, 45(6), 2005-2012.
  • Walsh, N., Bravo Nuevo, A., Geller, S., Stone, J. (2004). Resistance of photoreceptors in the C57BL/6-c2J, C57BL/6J, and BALB/cJ mouse strains to oxygen stress: Evidence of an oxygen phenotype. Current Eye Research, 29(6), 441-447.
  • Stone, J., Valter-Kocsi, K. (2004). Roles of retinal macroglia in maintaining the stability of the retina. Advances in Molecular and Cell Biology, 31, 295-313.
  • Valter-Kocsi, K., Bisti, S., Stone, J. (2003). Location of CNTFRα on outer segments: Evidence of the site of action of CNTF in rat retina. Brain Research, 985(2), 169-175.
  • Sandercoe, T., Geller, S., Hendrickson, A., Stone, J., Provis, J. (2003). VEGF expression by ganglion cells in central retina before formation of the foveal depression in monkey retina: Evidence of developmental hypoxia. The Journal of Comparative Neurology, 462(1), 42-54. [More Information]
  • Mervin, K., Stone, J. (2002). Developmental death of photoreceptors in the C57BL/6J mouse: association with retinal function & self-protection. Experimental Eye Research, 75(6), 703-713. [More Information]
  • Valter-Kocsi, K., Van Driel, D., Bisti, S., Stone, J. (2002). FGFR1 Expression and FGFR1-FGF-2 colocalisation in rat retina: sites of FGF-2 action on rat photoreceptors. Growth Factors, 20(4), 177-188.
  • Mervin, K., Stone, J. (2002). Regulation by oxygen of photoreceptor death in the developing & adult C57BL/6J mouse. Experimental Eye Research, 75(6), 715-722. [More Information]
  • Walsh, N., Valter-Kocsi, K., Stone, J. (2001). Cellular & subcellular patterns of expression of bFGF and CNTF in the normal & light stressed adult rat retina. Experimental Eye Research, 72 (5), 495-501.
  • Bowers, F., Valter-Kocsi, K., Chan, S., Walsh, N., Maslim, J., Stone, J. (2001). Effects of oxygen and bFGF on the vulnerability of photoreceptors to light damage. Investigative Ophthalmology and Visual Science, 42 (3), 804-815.
  • Stone, J., Maslim, J., Fawzi, A., Lancaster, P., Heckenlively,, R. (2001). The role of perinatal stress in simplex retinitis pigmentosa: evidence from surveys in Australia & the United States. Canadian Journal of Ophthalmology, 36 (6), 315-322.

Conferences

  • Kirk, D., Gopalakrishnan, S., Schmitt, H., Abroe, B., Stoehr, M., Dubis, A., Carroll, J., Stone, J., Valter, K., Eells, J. (2013). Photobiomodulation Reduces Photoreceptor Death and Regulates Cytoprotection in Early States of P23H Retinal Dystrophy. Mechanisms for Low-Light Therapy VIII, Bellingham: SPIE Society of Photo-Optical Instrumentation Engineers. [More Information]
  • Stone, J., Johnstone, D., Mitrofanis, J. (2013). The helmet experiment in Parkinson's disease: an observation of the mechanism of neuroprotection by near infra-red light. The 9th World Association for Laser Therapy Congress, Bologna, Italy: Medimond International Proceedings.

2014

  • Di Marco, F., Di Paolo, M., Romeo, S., Colecchi, L., Fiorani, L., Spana, S., Stone, J., Bisti, S. (2014). Combining Neuroprotectants in a Model of Retinal Degeneration: No Additive Benefit. PloS One, 9(6), e100389. [More Information]
  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274(C), 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Brandli, A., Stone, J. (2014). Remote Ischemia Influences the Responsiveness of the Retina: Observations in the Rat. Investigative Ophthalmology & Visual Science, 55(4), 2088-2096. [More Information]
  • Johnstone, D., Coleman, K., Moro, C., Torres, N., Eells, J., Baker, G., Ashkan, K., Stone, J., Benabid, A., Mitrofanis, J. (2014). The potential of light therapy in Parkinson's disease. ChronoPhysiology and Therapy, 4, 1-14. [More Information]

2013

  • Stone, J., De La Torre, J. (2013). Alzheimer's disease is associated with increased risk of haemorrhagic stroke. Evidence-Based Mental Health, 16(3), 88. [More Information]
  • Moro, C., Torres, N., El Massri, N., Ratel, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A. (2013). Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. BMC Neuroscience, 14(1), 1-9. [More Information]
  • Kirk, D., Gopalakrishnan, S., Schmitt, H., Abroe, B., Stoehr, M., Dubis, A., Carroll, J., Stone, J., Valter, K., Eells, J. (2013). Photobiomodulation Reduces Photoreceptor Death and Regulates Cytoprotection in Early States of P23H Retinal Dystrophy. Mechanisms for Low-Light Therapy VIII, Bellingham: SPIE Society of Photo-Optical Instrumentation Engineers. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Stone, J., Johnstone, D., Mitrofanis, J. (2013). The helmet experiment in Parkinson's disease: an observation of the mechanism of neuroprotection by near infra-red light. The 9th World Association for Laser Therapy Congress, Bologna, Italy: Medimond International Proceedings.
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]
  • Purushothuman, S., Marotte, L., Stowe, S., Johnstone, D., Stone, J. (2013). The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model. PloS One, 8(3), 1-18. [More Information]
  • Di Marco, F., Romeo, S., Nandasena, S., Purushothuman, S., Adams, C., Bisti, S., Stone, J. (2013). The time course of action of two neuroprotectants, dietary saffron and photobiomodulation, assessed in the rat retina. American Journal of Neurodegenerative Disease, 2(3), 208-220.

2012

  • Shaw, V., Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice. Parkinson's Disease, 2012, 1-9. [More Information]
  • Peoples, C., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2012). Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease. Parkinsonism & Related Disorders, 18(5), 468-476. [More Information]
  • Peoples, C., Shaw, V., Stone, J., Jeffery, G., Baker, G., Mitrofanis, J. (2012). Survival of Dopaminergic Amacrine Cells after Near-Infrared Light Treatment in MPTP-Treated Mice. ISRN Neurology, 2012, 1-8. [More Information]

2011

  • Natoli, R., Valter, K., Chrysostomou, V., Stone, J., Provis, J. (2011). Morphological, functional and gene expression analysis of the hyperoxic mouse retina. Experimental Eye Research, 92(4), 306-314. [More Information]

2010

  • Chrysostomou, V., Stone, J., Valter, K. (2010). Differences in Photoreceptor Sensitivity to Oxygen Stress Between Long Evans and Sprague-Dawley Rats. In Robert Anderson, Matthew LaVail, Joe Hollyfield (Eds.), Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations, (pp. 473-479). New York: Springer Science + Business Media.
  • Zhu, Y., Natoli, R., Valter, K., Stone, J. (2010). Differential gene expression in mouse retina related to regional differences in vulnerability to hyperoxia. Molecular Vision, 16, 740-755. [More Information]
  • Zhu, Y., Valter, K., Stone, J. (2010). Environmental Damage to the Retina and Preconditioning: Contrasting Effects of Light and Hyperoxic Stress. Investigative Ophthalmology and Visual Science, 51(9), 4821-4830. [More Information]
  • Natoli, R., Zhu, Y., Valter, K., Bisti, S., Stone, J., Ellis, J. (2010). Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina. Molecular Vision, 16, 1801-1822. [More Information]
  • Zhu, Y., Natoli, R., Valter, K., Stone, J. (2010). Microarray Analysis of Hyperoxia Stressed Mouse Retina: Differential Gene Expression in the Inferior and Superior Region. In Robert Anderson, Matthew LaVail, Joe Hollyfield (Eds.), Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations, (pp. 217-222). New York: Springer Science + Business Media.
  • Shaw, V., Spana, S., Ashkan, K., Benabid, A., Stone, J., Baker, G., Mitrofanis, J. (2010). Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment. The Journal of Comparative Neurology, 518(1), 25-40. [More Information]

2009

  • Stone, J., Heckenlively, J. (2009). Animal models of inherited retinal degenerations. In Binder MD, Hirokawa N, Windhorst U, Hirsch M. (Eds.), Encyclopedia of Neuroscience, (pp. 437-447). New York: Springer.
  • Chrysostomou, V., Valter, K., Stone, J. (2009). Cone-rod dependence in the rat retina: variation with the rate of rod damage. Investigative Ophthalmology and Visual Science, 50(6), 3017-3023. [More Information]
  • Chrysostomou, V., Stone, J., Valter, K. (2009). Life history of cones in the rhodopsin-mutant P23H-3 rat: evidence of long-term survival. Investigative Ophthalmology and Visual Science, 50(5), 2407-2416. [More Information]
  • Valter, K., Kirk, D., Stone, J. (2009). Optimising the structure and function of the adult P23H-3 retina by light management in the juvenile and adult. Experimental Eye Research, 89(6), 1003-1011. [More Information]

2008

  • Natoli, R., Provis, J., Valter, K., Stone, J. (2008). Expression and Role of the Early-Response Gene Oxrl in the Hyperoxia-Challenged Mouse Retina. Investigative Ophthalmology and Visual Science, 49(10), 4561-4567. [More Information]
  • Natoli, R., Provis, J., Valter, K., Stone, J. (2008). Gene regulation induced in the C57BL/6J mouse retina by hyperoxia: a temporal microarray study. Molecular Vision, 14, 1983-1994. [More Information]
  • Stone, J. (2008). Into a Maelstrom: One Man's Arrival in Mid-20th Century Australia. National Library of Australia News, 19, 18-21.
  • Eells, J., DeSmet, K., Kirk, D., Wong-Riley, M., Whelan, H., Ver Hoeve, J., Nork, T., Stone, J., Valter-Kocsi, K. (2008). Photobiomodulation for the Treatment of Retinal Injury and Retinal Degenerative Diseases. Lecture Notes in Electrical Engineering, 12, 39-51.
  • Stone, J., Valter, K. (2008). Roles of Oxygen in the Stability of Photoreceptors: Evidence from Mouse and Other Models of Human Disease. In Chalupa L; Williams R (Eds.), Eye, Retina, and Visual System of the Mouse, (pp. 559-572). Cambridge, Massachusetts: MIT Press.
  • Stone, J., Van Driel, D., Valter, K., Rees, S., Provis, J. (2008). The locations of mitochondria in mammalian photoreceptors: Relation to retinal vasculature. Brain Research, 1189, 58-69. [More Information]
  • Valter, K., Kirk, D., Stone, J. (2008). The potential of ambient light restriction to restore function to the degenerating P23H-3 rat retina. Advances in Experimental Medicine and Biology, 613, 193-199. [More Information]
  • Chrysostomou, V., Stone, J., Stowe, S., Barnett, N., Valter-Kocsi, K. (2008). The status of cones in the rhodopsin mutant P23H-3 retina: Light-regulated damage and repair in parallel with rods. Investigative Ophthalmology and Visual Science, 49(3), 1116-1125. [More Information]
  • Stone, J. (2008). What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages. Medical Hypotheses, 71(3), 347-359. [More Information]

2007

  • Bravo Nuevo, A., Williams, N., Valter-Kocsi, K., Stone, J. (2007). Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains. Mitochondrion, 7(5), 340-346. [More Information]

2006

  • Stone, J., Sandercoe, T., Provis, J. (2006). Mechanisms of the Formation and Stability of Retinal Blood Vessels. In Joyce Tombran-Tink and Colin J. Barnstable (Eds.), Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics, (pp. 101-126). United States: Humana Press.
  • Cullen, K., Kócsi, Z., Stone, J. (2006). Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1786-1796. [More Information]
  • Cullen, K., Kocsi, Z., Stone, J. (2006). Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1786-1796.
  • Jozwick, C., Valter-Kocsi, K., Stone, J. (2006). Reversal of functional loss in the P23H-3 rat retina by management of ambient light. Experimental Eye Research, 83(5), 1074-1080. [More Information]
  • Geller, S., Krowka, R., Valter-Kocsi, K., Stone, J. (2006). Toxicity of Hyperoxia to the Retina: Evidence from the Mouse. In Joe G. Hollyfield, Richard E. Anderson, Matthew M. Lavail (Eds.), Advances in Experimental Medicine and Biology: Retinal Degenerative Diseases, (pp. 425-437). United States: Springer.

2005

  • Cullen, K., Kocsi, Z., Stone, J. (2005). Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. Journal of Cerebral Blood Flow and Metabolism, 25(12), 1656-1667. [More Information]
  • Stone, J., Mervin, K., Penfold, P., Walsh, N., Provis, J., Valter-Kocsi, K. (2005). Photoreceptor stability and degeneration in mammalian retina: lesson from the edge. In Penfold P; Provis J (Eds.), Macular Degeneration, (pp. 149-165). Germany: Springer.
  • Wellard, J., Lee, D., Valter-Kocsi, K., Stone, J. (2005). Photoreceptors in the rat retina are specifically vulnerable to both hypoxia and hyperoxia. Visual Neuroscience, 22(4), 501-507. [More Information]
  • Valter-Kocsi, K., Bisti, S., Gargini, C., Di Loreto, S., Maccarone, R., Cervetto, L., Stone, J. (2005). Time course of neurotrophic factor upregulation and retinal protection against light-induced damage after optic nerve section. Investigative Ophthalmology and Visual Science, 46(5), 1748-1754. [More Information]
  • Geller, S., Krowka, R., Valter-Kocsi, K., Stone, J. (2005). Toxicity of hyperoxia to the retina: Evidence from the mouse. Advances in Experimental Medicine and Biology, 572(Chapter 60), 425-437. [More Information]

2004

  • Gragini, C., Bisti, S., Demontis, G., Valter-Kocsi, K., Stone, J., Cervetto, L. (2004). Electroretinogram Changes Associated With Retinal Upregulation Of Trophic Factors: Observations Following Optic Nerve Section. Neuroscience, 126(3), 775-783.
  • Walsh, N., Van Driel, D., Lee, D., Stone, J. (2004). Multiple Vulnerability Of Photoreceptors To Mesopic Ambient Light In The P23H Transgenic Rat. Brain Research, 1013 (2), 194-203. [More Information]
  • Yu, D., Cringle, S., Valter-Kocsi, K., Walsh, N., Lee, D., Stone, J. (2004). Photoreceptor Death, Trophic Factor Expression, Retinal Oxygen Status, And Photoreceptor Function In The P23H Rat. Investigative Ophthalmology and Visual Science, 45(6), 2013-2019.
  • Bravo Nuevo, A., Walsh, N., Stone, J. (2004). Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse. Investigative Ophthalmology and Visual Science, 45(6), 2005-2012.
  • Walsh, N., Bravo Nuevo, A., Geller, S., Stone, J. (2004). Resistance of photoreceptors in the C57BL/6-c2J, C57BL/6J, and BALB/cJ mouse strains to oxygen stress: Evidence of an oxygen phenotype. Current Eye Research, 29(6), 441-447.
  • Stone, J., Valter-Kocsi, K. (2004). Roles of retinal macroglia in maintaining the stability of the retina. Advances in Molecular and Cell Biology, 31, 295-313.

2003

  • Valter-Kocsi, K., Bisti, S., Stone, J. (2003). Location of CNTFRα on outer segments: Evidence of the site of action of CNTF in rat retina. Brain Research, 985(2), 169-175.
  • Bravo Nuevo, A., Williams, N., Geller, S., Stone, J. (2003). Mitochondrial deletions in normal and degenerating rat retina. In Matthew M. Lavail, Joe G. Hollyfield, Robert E. Anderson (Eds.), Retinal Degenerations: Mechanisms and Experimental Therapy, (pp. 241-248). NY: Springer.
  • Lee, D., Geller, S., Walsh, N., Valter-Kocsi, K., Stone, J., Yasumura, D., Matthes, M., La Vail, M. (2003). Photoreceptor Degeneration in PRO23HIS and S334TER Transgenic Rats. In Matthew M. Lavail, Joe G. Hollyfield, Robert E. Anderson (Eds.), Retinal Degenerations: Mechanisms and Experimental Therapy, (pp. 297-302). NY: Springer.
  • Geller, S., Stone, J. (2003). Quantiative PCR analysis of FosB mRNA expression afger short duration oxygen and light stress. In Matthew M. Lavail, Joe G. Hollyfield, Robert E. Anderson (Eds.), Retinal Degenerations: Mechanisms and Experimental Therapy, (pp. 249-258). NY: Springer.
  • Sandercoe, T., Geller, S., Hendrickson, A., Stone, J., Provis, J. (2003). VEGF expression by ganglion cells in central retina before formation of the foveal depression in monkey retina: Evidence of developmental hypoxia. The Journal of Comparative Neurology, 462(1), 42-54. [More Information]

2002

  • Mervin, K., Stone, J. (2002). Developmental death of photoreceptors in the C57BL/6J mouse: association with retinal function & self-protection. Experimental Eye Research, 75(6), 703-713. [More Information]
  • Valter-Kocsi, K., Van Driel, D., Bisti, S., Stone, J. (2002). FGFR1 Expression and FGFR1-FGF-2 colocalisation in rat retina: sites of FGF-2 action on rat photoreceptors. Growth Factors, 20(4), 177-188.
  • Mervin, K., Stone, J. (2002). Regulation by oxygen of photoreceptor death in the developing & adult C57BL/6J mouse. Experimental Eye Research, 75(6), 715-722. [More Information]

2001

  • Walsh, N., Valter-Kocsi, K., Stone, J. (2001). Cellular & subcellular patterns of expression of bFGF and CNTF in the normal & light stressed adult rat retina. Experimental Eye Research, 72 (5), 495-501.
  • Bowers, F., Valter-Kocsi, K., Chan, S., Walsh, N., Maslim, J., Stone, J. (2001). Effects of oxygen and bFGF on the vulnerability of photoreceptors to light damage. Investigative Ophthalmology and Visual Science, 42 (3), 804-815.
  • Stone, J., Fisher, S., Rex, T., Linberg, K., Lewis, G. (2001). Experimental retinal detachment: a paradigm for understanding the effects of induced photoreceptor degeneration. In H Kolb, H Ripps, S Wu (Eds.), Concepts and Challenges in Retinal Biology, (pp. 679-698). United States: Elsevier.
  • Stone, J., Maslim, J., Fawzi, A., Lancaster, P., Heckenlively,, R. (2001). The role of perinatal stress in simplex retinitis pigmentosa: evidence from surveys in Australia & the United States. Canadian Journal of Ophthalmology, 36 (6), 315-322.
  • Walsh, N., Stone, J. (2001). Timecourse of bFGF and CNTF expression in light-induced photoreceptor degeneration in the rat retina. In Robert E Anderson, Matthew M LaVail, Joe G Hollyfield (Eds.), New Insights into Retinal Degenerative Diseases, (pp. 111-118). New York USA: Academic Press.

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