Associate Professor Jonathon Arnold

Associate Professor
Pharmacology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9036 5361
Fax +61 2 9351 7328

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Biographical details

Jonathon Arnold is an Associate Professor at the University of Sydney and has over 19 years experience in behavioural neuroscience and psychopharmacology. In 2005 he conducted research at the Cajal Institute in Madrid, one of the world's premier neuroscience institutes. In 2009 A/Prof Arnold established the Neurobehavioural Laboratory at the Brain and Mind Research Institute (BMRI). He has published 47 manuscripts and has received over 1200 career citations (h-index = 22). His research has attracted national and international funding. In 2010, he was awarded an internationally competitive Young Investigator Grant from the Brain and Behavior Research Foundation (US). His laboratory aims to understand how stress and drugs affect the brain and behavior. He utilizes various mouse models of neuropsychiatric conditions including addiction, anxiety, depression, post-traumatic stress disorder (PTSD) and schizophrenia. A typical day in his lab will see students measuring animal behaviour, performing western blots or immunohistochemistry or analysing CNS-cell morphology (microglia,astrocytes, oligodendrocytes and neurons). He is currently developing new techniques such as in vivo imaging of synapses and optogenetics to establish brain cell-behaviour relationships.

Research interests

A/Prof Arnold’s research has principally focussed on the psychopharmacology of drugs of abuse, particularly cannabinoids (cannabis-like drugs) and its role in affecting psychiatric conditions. His team has isolated genes that modulate the neurobehavioural effects of cannabinoids which have important implications for understanding the genetic basis of cannabis-induced psychosis and cannabis dependence. His group showed for the first time that cannabinoids modulate the activity and expression of various ABC transporters. In 2012 his group reported that the ABC transporters P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) regulate the brain uptake and effects of the propsychotic tetrahydrocannabinol (THC). This provided a mechanism for the observation that P-gp influences the risk of cannabis dependence in humans.

His group was the first to demonstrate that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) altered the neurobehavioural actions of cannabinoids. The two seminal manuscripts on this topic published in 2007 have collectively received 165 citations. In total 13 research manuscripts in this area have been published. This work was translated, with two human studies citing his instructive animal work: the first showed NRG1 increased the risk of cannabis dependence (Biol Psychiatry,2012); the second reported that NRG1 enhanced the effects of cannabinoids on mismatch negativity (Pharmacopsychiatry,2010). His research on Nrg1-cannabinoid interactions also paved the way for new research examining interplay between endocannabinoid (eCB) and Nrg1-ErbB receptor systems, e.g. Nrg1 increases the degradation of the eCB 2-AG (J Neurosci,2013). In recent years he has broadened his Nrg1 research. In 2014 his group showed that partial genetic deletion of Nrg1 confers vulnerability to stress which was published in the world’s premier schizophrenia research journal, Schizophrenia Bulletin. His recent work has focussed on how genes confer vulnerability to the effects of stress which has relevance to our understanding of anxiety, depression, post-traumatic stress disorder and schizophrenia. He has taken on a particular interest in how genes and stressors interact during neurodevelopment to disturb neuronal connectivity.

Another major contribution of A/Prof Arnold’s research is the discovery that dieting and exercise elevated blood concentrations of THC by dislodging fat-soluble THC from adipose tissue. This phenomenon has far-reaching practical implications providing a means for false positive drug tests in the absence of recent cannabis use and a mechanism of cannabis flashback or re-intoxication. The initial research on this topic was performed in cell culture and animal experiments, but was recently translated in a human study co-directed by A/Prof Arnold. Both these studies attracted national and international media attention including coverage in the New Scientist, Time Magazine and the Sun-Herald. An extension of this work was NHMRC-funded in 2013.

Teaching and supervision

A/Prof Arnold coordinates PCOL2605, Pharmacology for Pharmacy.

In 2011 A/Prof Arnold was awarded an excellence in PhD supervision award from the Sydney Medical School underscoring his commitment to training the best scientists of tomorrow.He is the primary supervisor of 4 PhD students and has supervised 5 PhD students, 1 Masters and 13 Honours students to completion (10 awarded a firstclass grading).

SERVICE TO THE COMMUNITY, THE UNIVERSITY AND HIS DISCIPLINE

A/Prof Arnold serves on the Editorial Board of Current Neuropharmacology and The World Journal of Pharmacology.

He reviews grants for the National Health and Medical Research Council, Australian Research Council, the Marsden Fund (New Zealand) and the Michael Smith Foundation for Health Research (Canada). He also reviews original research manuscripts for various international journals including Schizophrenia Bulletin, Biological Psychiatry, Neuropsychopharmacology, PLoS ONE and The British Journal of Pharmacology.

A/Prof Arnold provides expert witness testimony on medicolegal cases involving drugs. He has given evidence at the Coroner's, Supreme and local courts of Australia.He has appeared on national television and radio commenting on the medicinal and adverse effects of cannabis (e.g.Channel 10News,ABCRadio).

He was a member of the Animal Ethics Committee 2012-2013.

International links

France

(University of Bordeaux) Prof Jacques Micheau

United States

(Skirball Institute New York) Professor Wenbiao Gan

Selected grants

2014

  • Randomised control trial of exercise for the management of cannabis withdrawal in adult humans; Lintzeris N, McGregor I, Rooney K, Allsop D, Arnold J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Stereotaxic frame; Arnold J, Christie M, Collins M, Sawatari A, Leamey C, Stone J, van Nieuwenhuijzen P, Chan-Ling T, Balle T; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Mouse behavioural phenotyping battery; Hunt N, Christie M, McGregor I, Kassiou M, Collins M, Stone J, Arnold J, Sawatari A, Mitrofanis J, Camp A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • ABC transporters and cannabis-induced psychosis; Arnold J; DVC Research/Bridging Support Grant.

2012

  • A flexible high throughput analytical system for psychopharmacology and drug discovery; McGregor I, Simpson S, Shannon Weickert C, Kassiou M, Copeland J, Solowij N, Codd R, Arnold J, Karl T, Long L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2011

  • Neuregulini and stress interact to promote schizophrenia; Arnold J; DVC Research/Bridging Support Grant.

2010

  • An animal model of gene-environment interaction in Schizophrenia: equipment purchase; Arnold J; Schizophrenia Research Institute/Research Support.
  • Role of ABC transporters in resistance to antipsychotic therapy and cannabinoid antipsychotic drug interactions; Arnold J; Brain and Behavior Research Foundation/Research Support.

2009

  • Atypical antipsychotic-induced weight gain and insulin insensitivity: a role for macrophage infiltration in adipose tissue; Arnold J; Schizophrenia Research Institute/Research Support.
  • A new Laser Microdissection Microscope with a unique pressure catapulting technique allows isolation of pure samples for subsequent downstream molecular analyses; Halliday G, Morris B, Mason R, Murphy C, Bishop A, Leamey C, Joshua D, Lee C, Iland H, Pamphlett R, Richardson D, King N, Hunt N, Arnold J, Morris M, Protti D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Motion Menura multimodal mouse testing apparatus (MMTA): (Turnkey system comprising 6 testing chambers with associated control and tracking software).; Kemp A, Hermens D, McGregor I, Einfeld S, Kassiou M, Arnold J, Hunt G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • The role of cannabis in an Nrg1 animal model of genetic vulnerability to schizophrenia; Arnold J; Schizophrenia Research Institute/Research Support.

2007

  • 12th biennial meeting of the european behavioural pharmacology society - Germany September 2007; Arnold J; Ian Potter Foundation/Grants & Travel Grants.

2006

  • Cannabis re-intoxication: the causes and consequences of THC release from fat stores into blood; McGregor I, Arnold J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • An Animal Model Of Genetic Vulnerability To Cannabis-Induced Psychosis; Arnold J; Clive & Vera Ramaciotti Foundation/General Grants.

2005

  • Flashback: the release of THC from fat stores as a result of food deprivation or stress; McGregor I, Arnold J; University of Sydney/Research & Development.

2004

  • Cannabinoids as anti-cancer agents:studies evaluating cytotoxic and multidrug resistance(MDR)reversal actions; Arnold J; University of Sydney/Cancer Research Fund.

2002

  • Cannabinoids as agents that reverse resistance to chemotherapy; Arnold J; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).

Selected publications

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Journals

  • Ireland, T., Larkin, X., Arnold, J., Holsinger, D. (2014). A Novel Segmentation-Based Algorithm for the Quantification of Magnified Cells. Journal Of Cellular Biochemistry, 115, 1849-1854. [More Information]
  • Wong, A., Keats, K., Rooney, K., Hicks, C., Allsop, D., Arnold, J., McGregor, I. (2014). Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an examination of behavioural consequences. Psychopharmacology, 231(20), 3987-3996. [More Information]
  • Swift, W., Wong, A., Li, K., Arnold, J., McGregor, I. (2013). Analysis of cannabis seizures in NSW, Australia: Cannabis potency and cannabinoid profile. PLoS One, 8(7), 1-9. [More Information]
  • Wong, A., Montebello, M., Norberg, M., Rooney, K., Lintzeris, N., Bruno, R., Booth, J., Arnold, J., McGregor, I. (2013). Exercise increases plasma THC concentrations in regular cannabis users. Drug and Alcohol Dependence, 133(2), 763-767. [More Information]
  • Spencer, J., Chohan, T., Karl, T., Arnold, J. (2013). Female neuregulin 1 heterozygous mice require repeated exposure to Δ9-tetrahydrocannabinol to alter sensorimotor gating function. Pharmacopsychiatry, 46(7), 286-291. [More Information]
  • Spencer, J., Darbyshire, K., Boucher, A., Kashem, M., Long, L., McGregor, I., Karl, T., Arnold, J. (2013). Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice. Frontiers in Cellular Neuroscience, 7, 1-13. [More Information]
  • Kassem, M., Lagopoulos, J., Stait-Gardner, T., Price, W., Chohan, T., Arnold, J., Hatton, S., Bennett, M. (2013). Stress-Induced Grey Matter Loss Determined by MRI Is Primarily Due to Loss of Dendrites and Their Synapses. Molecular Neurobiology, 47(2), 645-661. [More Information]
  • Long, L., Chesworth, R., Huang, X., McGregor, I., Arnold, J., Karl, T. (2013). Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence. International Journal of Neuropsychopharmacology, 16(1), 163-175. [More Information]
  • Karl, T., Arnold, J. (2013). What does a mouse tell us about neuregulin 1-cannabis interactions? Frontiers in Cellular Neuroscience, 7, 1-4. [More Information]
  • Spencer, J., Darbyshire, K., Boucher, A., Arnold, J. (2012). Adolescent neuregulin 1 heterozygous mice display enhanced behavioral sensitivity to methamphetamine. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 39(2), 376-381. [More Information]
  • Arnold, J., Hone, P., Holland, M., Allen, J. (2012). CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells. Pharmacological Reports, 64(3), 751-757. [More Information]
  • Long, L., Chesworth, R., Huang, X., Wong, A., Spiro, A., McGregor, I., Arnold, J., Karl, T. (2012). Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice. PLoS One, 7(4), 1-11. [More Information]
  • Spiro, A., Wong, A., Boucher, A., Arnold, J. (2012). Enhanced Brain Disposition and Effects of triangle 9-Tetrahydrocannabinol in P-Glycoprotein and Breast Cancer Resistance Protein Knockout Mice. PLoS One, 7(4), 1-6. [More Information]
  • Wong, A., Gunasekaran, N., Hancock, D., Denyer, G., Meng, L., Radford, J., McGregor, I., Arnold, J. (2012). The major plant-derived cannabinoid 9-tetrahydrocannabinol promotes hypertrophy and macrophage infiltration in adipose tissue. Hormone And Metabolic Research, 44(2), 105-113. [More Information]
  • Chesworth, R., Yulyaningsih, E., Cappas, E., Arnold, J., Salis (nee Sainsbury), A., Karl, T. (2012). The response of neuregulin 1 mutant mice to acute restraint stress. Neuroscience Letters, 515(1), 82-86. [More Information]
  • Karl, T., Cheng, D., Garner, B., Arnold, J. (2012). The therapeutic potential of the endocannabinoid system for Alzheimer's disease. Expert Opinion on Therapeutic Targets, 16(4), 407-420. [More Information]
  • Arnold, J., Boucher, A., Karl, T. (2012). The Yin and Yang of Cannabis-induced Psychosis: the Actions of (D)(9)-Tetrahydrocannabinol and Cannabidiol in Rodent Models of Schizophrenia. Current Pharmaceutical Design, 18(32), 5113-5130. [More Information]
  • Bowen, M., Carson, D., Spiro, A., Arnold, J., McGregor, I. (2011). Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats. PLoS One, 6(11), 1 (e27237)-11. [More Information]
  • Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L., Huang, X., Arnold, J., McGregor, I., et al (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443-457. [More Information]
  • Ferguson (Sokolic), L., Long, L., Hunt, G., Arnold, J., McGregor, I. (2011). Disruptive effects of the prototypical cannabinoid Delta9-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats. Behavioural Pharmacology, 22(3), 191-202. [More Information]
  • Boucher, A., Arnold, J., Hunt, G., Spiro, A., Spencer, J., Brown, C., McGregor, I., Bennett, M., Kassiou, M. (2011). Resilience and Reduced C-FOS Expression in P2X7 Receptor Knockout Mice Exposed to Repeated Forced Swim Test. Neuroscience, 189, 170-177. [More Information]
  • Boucher, A., Hunt, G., Micheau, J., Huang, X., McGregor, I., Karl, T., Arnold, J. (2011). The schizophrenia-susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. International Journal of Neuropsychopharmacology, 14(5), 631-643. [More Information]
  • Long, L., Chesworth, R., Arnold, J., Karl, T. (2010). A follow-up study: acute behavioural effects of Delta(9)-THC in female heterozygous neuregulin 1 transmembrane domain mutant mice. Psychopharmacology, 211(3), 277-289. [More Information]
  • Arnold, J., Dielenberg, R., McGregor, I. (2010). Cannabinoids increase conditioned ultrasonic vocalisations and cat odour avoidance in rats: Strain differences in drug-induced anxiety. Life Sciences, 87(17-18), 572-578. [More Information]
  • van Nieuwenhuijzen, P., Long, L., Hunt, G., Arnold, J., McGregor, I. (2010). Residual social, memory and oxytocin-related changes in rats following repeated exposure to gamma-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Psychopharmacology, 212(4), 663-674. [More Information]
  • Carson, D., Hunt, G., Guastella, A., Barber, L., Cornish, J., Arnold, J., Boucher, A., McGregor, I. (2010). Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus. Addiction Biology, 15(4), 448-463. [More Information]
  • Boucher, A., Hunt, G., Micheau, J., Huang, X., McGregor, I., Karl, T., Arnold, J. (2010). The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. International Journal of Neuropsychopharmacology, 14(5), 631-643. [More Information]
  • Long, L., Chesworth, R., Huang, X., McGregor, I., Arnold, J., Karl, T. (2009). A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. International Journal of Neuropsychopharmacology, 13 (2010)(7), 861-876. [More Information]
  • Boucher, A., Vivier, L., Metna-Laurent, M., Brayda-Bruno, L., Mons, N., Arnold, J., Micheau, J. (2009). Chronic treatment with [DELTA]9-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. Behavioural Pharmacology, 20(1), 45-55. [More Information]
  • Gunasekaran, N., Long, L., Dawson, B., Hansen, G., Richardson, D., Li, K., Arnold, J., McGregor, I. (2009). Reintoxication: the release of fat-stored delta-9-tetrahydrocannabinol (THC) into blood is enhanced by food deprivation or ACTH exposure. British Journal of Pharmacology, 158(5), 1330-1337. [More Information]
  • Holland, M., Allen, J., Arnold, J. (2008). Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). European Journal of Pharmacology, 591, 128-131. [More Information]
  • Quinn, H., Matsumoto, I., Callaghan, P., Long, L., Arnold, J., Gunasekaran, N., Thompson, M., Dawson, B., Mallet, P., Kashem, M., Matsuda-Matsumoto, H., Iwazaki, T., McGregor, I. (2007). Adolescent rats find repeated delta-9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology, 33 (epub ahead of print Jun 20), 1-14. [More Information]
  • McGregor, I., Arnold, J. (2007). Cannabis reward: biased towards the fairer sex? British Journal of Pharmacology, 152(5), 562-564. [More Information]
  • Boucher, A., Arnold, J., Duffy, L., Schofield, P., Micheau, J., Karl, T. (2007). Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Δ9-tetrahydrocannabinol. Psychopharmacology, 192(3), 325-336. [More Information]
  • Boucher, A., Hunt, G., Karl, T., Micheau, J., McGregor, I., Arnold, J. (2007). Heterozygous neuregulin 1 mice display greater baseline and Delta(9)-tetrahydrocannabinol-induced c-Fos expression. Neuroscience, 149(4), 861-870. [More Information]
  • Holland, M., Lau, D., Allen, J., Arnold, J. (2007). The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. British Journal of Pharmacology, 152(5), 815-824. [More Information]
  • Karl, T., Duffy, L., Boucher, A., Arnold, J., Schofield, P. (2006). Genetic animal models for neuregulin 1 – valuable tools for schizophrenia research? Australian and New Zealand Journal of Psychiatry, 40(8, Supplement 2, Point No: O16), A115-A115.
  • Holland, M., Panetta, J., Hoskins, J., Bebawy, M., Roufogalis, B., Allen, J., Arnold, J. (2006). The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochemical Pharmacology, 71(8), 1146-1154. [More Information]
  • Morley, K., Arnold, J., McGregor, I. (2005). Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(5), 648-657. [More Information]
  • Arnold, J. (2005). The role of endocannabinoid transmission in cocaine addiction. Pharmacology, Biochemistry and Behavior, 81(2), 396-406. [More Information]
  • Arnold, J., Hunt, G., McGregor, I. (2001). Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rat. Life Sciences, 70, 97-108.
  • Arnold, J., Topple, A., Hunt, G., McGregor, I., Mallet, P. (2001). The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain. Brain Research, 921, 240-255.

Conferences

  • Holland, M., Allen, J., Bebawy, M., Roufogalis, B., Arnold, J. (2005). Cannabinoid Modulation of P-Glycoprtein Efflux Activity and Expression (Netherlands). Interantional association for cannabis as medicine conference, The Netherlands: Australian Society of Clinical and experimental Pharmacologists and Toxicologista.
  • Arnold, J., Holland, M., Bebawy, M., Roufogalis, B., Allen, J. (2005). Cannabinoid Modulation of P-Glycoprtein Efflux Activity and Expression (Spain). SOCIEDAD ESPANOLA DE INVESTIGACION SOBRE CANNABINOIDES, Barcelona: Australian Society of Clinical and experimental Pharmacologists and Toxicologista.

2014

  • Ireland, T., Larkin, X., Arnold, J., Holsinger, D. (2014). A Novel Segmentation-Based Algorithm for the Quantification of Magnified Cells. Journal Of Cellular Biochemistry, 115, 1849-1854. [More Information]
  • Wong, A., Keats, K., Rooney, K., Hicks, C., Allsop, D., Arnold, J., McGregor, I. (2014). Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an examination of behavioural consequences. Psychopharmacology, 231(20), 3987-3996. [More Information]

2013

  • Swift, W., Wong, A., Li, K., Arnold, J., McGregor, I. (2013). Analysis of cannabis seizures in NSW, Australia: Cannabis potency and cannabinoid profile. PLoS One, 8(7), 1-9. [More Information]
  • Wong, A., Montebello, M., Norberg, M., Rooney, K., Lintzeris, N., Bruno, R., Booth, J., Arnold, J., McGregor, I. (2013). Exercise increases plasma THC concentrations in regular cannabis users. Drug and Alcohol Dependence, 133(2), 763-767. [More Information]
  • Spencer, J., Chohan, T., Karl, T., Arnold, J. (2013). Female neuregulin 1 heterozygous mice require repeated exposure to Δ9-tetrahydrocannabinol to alter sensorimotor gating function. Pharmacopsychiatry, 46(7), 286-291. [More Information]
  • Spencer, J., Darbyshire, K., Boucher, A., Kashem, M., Long, L., McGregor, I., Karl, T., Arnold, J. (2013). Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice. Frontiers in Cellular Neuroscience, 7, 1-13. [More Information]
  • Kassem, M., Lagopoulos, J., Stait-Gardner, T., Price, W., Chohan, T., Arnold, J., Hatton, S., Bennett, M. (2013). Stress-Induced Grey Matter Loss Determined by MRI Is Primarily Due to Loss of Dendrites and Their Synapses. Molecular Neurobiology, 47(2), 645-661. [More Information]
  • Long, L., Chesworth, R., Huang, X., McGregor, I., Arnold, J., Karl, T. (2013). Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence. International Journal of Neuropsychopharmacology, 16(1), 163-175. [More Information]
  • Karl, T., Arnold, J. (2013). What does a mouse tell us about neuregulin 1-cannabis interactions? Frontiers in Cellular Neuroscience, 7, 1-4. [More Information]

2012

  • Spencer, J., Darbyshire, K., Boucher, A., Arnold, J. (2012). Adolescent neuregulin 1 heterozygous mice display enhanced behavioral sensitivity to methamphetamine. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 39(2), 376-381. [More Information]
  • Arnold, J., Hone, P., Holland, M., Allen, J. (2012). CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells. Pharmacological Reports, 64(3), 751-757. [More Information]
  • Long, L., Chesworth, R., Huang, X., Wong, A., Spiro, A., McGregor, I., Arnold, J., Karl, T. (2012). Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice. PLoS One, 7(4), 1-11. [More Information]
  • Spiro, A., Wong, A., Boucher, A., Arnold, J. (2012). Enhanced Brain Disposition and Effects of triangle 9-Tetrahydrocannabinol in P-Glycoprotein and Breast Cancer Resistance Protein Knockout Mice. PLoS One, 7(4), 1-6. [More Information]
  • Wong, A., Gunasekaran, N., Hancock, D., Denyer, G., Meng, L., Radford, J., McGregor, I., Arnold, J. (2012). The major plant-derived cannabinoid 9-tetrahydrocannabinol promotes hypertrophy and macrophage infiltration in adipose tissue. Hormone And Metabolic Research, 44(2), 105-113. [More Information]
  • Chesworth, R., Yulyaningsih, E., Cappas, E., Arnold, J., Salis (nee Sainsbury), A., Karl, T. (2012). The response of neuregulin 1 mutant mice to acute restraint stress. Neuroscience Letters, 515(1), 82-86. [More Information]
  • Karl, T., Cheng, D., Garner, B., Arnold, J. (2012). The therapeutic potential of the endocannabinoid system for Alzheimer's disease. Expert Opinion on Therapeutic Targets, 16(4), 407-420. [More Information]
  • Arnold, J., Boucher, A., Karl, T. (2012). The Yin and Yang of Cannabis-induced Psychosis: the Actions of (D)(9)-Tetrahydrocannabinol and Cannabidiol in Rodent Models of Schizophrenia. Current Pharmaceutical Design, 18(32), 5113-5130. [More Information]

2011

  • Bowen, M., Carson, D., Spiro, A., Arnold, J., McGregor, I. (2011). Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats. PLoS One, 6(11), 1 (e27237)-11. [More Information]
  • Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L., Huang, X., Arnold, J., McGregor, I., et al (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443-457. [More Information]
  • Ferguson (Sokolic), L., Long, L., Hunt, G., Arnold, J., McGregor, I. (2011). Disruptive effects of the prototypical cannabinoid Delta9-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats. Behavioural Pharmacology, 22(3), 191-202. [More Information]
  • Boucher, A., Arnold, J., Hunt, G., Spiro, A., Spencer, J., Brown, C., McGregor, I., Bennett, M., Kassiou, M. (2011). Resilience and Reduced C-FOS Expression in P2X7 Receptor Knockout Mice Exposed to Repeated Forced Swim Test. Neuroscience, 189, 170-177. [More Information]
  • Boucher, A., Hunt, G., Micheau, J., Huang, X., McGregor, I., Karl, T., Arnold, J. (2011). The schizophrenia-susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. International Journal of Neuropsychopharmacology, 14(5), 631-643. [More Information]

2010

  • Long, L., Chesworth, R., Arnold, J., Karl, T. (2010). A follow-up study: acute behavioural effects of Delta(9)-THC in female heterozygous neuregulin 1 transmembrane domain mutant mice. Psychopharmacology, 211(3), 277-289. [More Information]
  • Arnold, J., Dielenberg, R., McGregor, I. (2010). Cannabinoids increase conditioned ultrasonic vocalisations and cat odour avoidance in rats: Strain differences in drug-induced anxiety. Life Sciences, 87(17-18), 572-578. [More Information]
  • van Nieuwenhuijzen, P., Long, L., Hunt, G., Arnold, J., McGregor, I. (2010). Residual social, memory and oxytocin-related changes in rats following repeated exposure to gamma-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Psychopharmacology, 212(4), 663-674. [More Information]
  • Carson, D., Hunt, G., Guastella, A., Barber, L., Cornish, J., Arnold, J., Boucher, A., McGregor, I. (2010). Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus. Addiction Biology, 15(4), 448-463. [More Information]
  • Boucher, A., Hunt, G., Micheau, J., Huang, X., McGregor, I., Karl, T., Arnold, J. (2010). The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. International Journal of Neuropsychopharmacology, 14(5), 631-643. [More Information]

2009

  • Long, L., Chesworth, R., Huang, X., McGregor, I., Arnold, J., Karl, T. (2009). A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. International Journal of Neuropsychopharmacology, 13 (2010)(7), 861-876. [More Information]
  • Boucher, A., Vivier, L., Metna-Laurent, M., Brayda-Bruno, L., Mons, N., Arnold, J., Micheau, J. (2009). Chronic treatment with [DELTA]9-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. Behavioural Pharmacology, 20(1), 45-55. [More Information]
  • Gunasekaran, N., Long, L., Dawson, B., Hansen, G., Richardson, D., Li, K., Arnold, J., McGregor, I. (2009). Reintoxication: the release of fat-stored delta-9-tetrahydrocannabinol (THC) into blood is enhanced by food deprivation or ACTH exposure. British Journal of Pharmacology, 158(5), 1330-1337. [More Information]

2008

  • Holland, M., Allen, J., Arnold, J. (2008). Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). European Journal of Pharmacology, 591, 128-131. [More Information]

2007

  • Quinn, H., Matsumoto, I., Callaghan, P., Long, L., Arnold, J., Gunasekaran, N., Thompson, M., Dawson, B., Mallet, P., Kashem, M., Matsuda-Matsumoto, H., Iwazaki, T., McGregor, I. (2007). Adolescent rats find repeated delta-9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology, 33 (epub ahead of print Jun 20), 1-14. [More Information]
  • McGregor, I., Arnold, J. (2007). Cannabis reward: biased towards the fairer sex? British Journal of Pharmacology, 152(5), 562-564. [More Information]
  • Boucher, A., Arnold, J., Duffy, L., Schofield, P., Micheau, J., Karl, T. (2007). Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Δ9-tetrahydrocannabinol. Psychopharmacology, 192(3), 325-336. [More Information]
  • Boucher, A., Hunt, G., Karl, T., Micheau, J., McGregor, I., Arnold, J. (2007). Heterozygous neuregulin 1 mice display greater baseline and Delta(9)-tetrahydrocannabinol-induced c-Fos expression. Neuroscience, 149(4), 861-870. [More Information]
  • Holland, M., Lau, D., Allen, J., Arnold, J. (2007). The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. British Journal of Pharmacology, 152(5), 815-824. [More Information]

2006

  • Karl, T., Duffy, L., Boucher, A., Arnold, J., Schofield, P. (2006). Genetic animal models for neuregulin 1 – valuable tools for schizophrenia research? Australian and New Zealand Journal of Psychiatry, 40(8, Supplement 2, Point No: O16), A115-A115.
  • Holland, M., Panetta, J., Hoskins, J., Bebawy, M., Roufogalis, B., Allen, J., Arnold, J. (2006). The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochemical Pharmacology, 71(8), 1146-1154. [More Information]

2005

  • Holland, M., Allen, J., Bebawy, M., Roufogalis, B., Arnold, J. (2005). Cannabinoid Modulation of P-Glycoprtein Efflux Activity and Expression (Netherlands). Interantional association for cannabis as medicine conference, The Netherlands: Australian Society of Clinical and experimental Pharmacologists and Toxicologista.
  • Arnold, J., Holland, M., Bebawy, M., Roufogalis, B., Allen, J. (2005). Cannabinoid Modulation of P-Glycoprtein Efflux Activity and Expression (Spain). SOCIEDAD ESPANOLA DE INVESTIGACION SOBRE CANNABINOIDES, Barcelona: Australian Society of Clinical and experimental Pharmacologists and Toxicologista.
  • Morley, K., Arnold, J., McGregor, I. (2005). Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(5), 648-657. [More Information]
  • Arnold, J. (2005). The role of endocannabinoid transmission in cocaine addiction. Pharmacology, Biochemistry and Behavior, 81(2), 396-406. [More Information]

2001

  • Arnold, J., Hunt, G., McGregor, I. (2001). Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rat. Life Sciences, 70, 97-108.
  • Arnold, J., Topple, A., Hunt, G., McGregor, I., Mallet, P. (2001). The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain. Brain Research, 921, 240-255.

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