Dr Josep Font Sadurni

Lecturer
Pharmacology, School of Medical Sciences
Bosch Institute

Telephone + 61 2 991141458

Curriculum vitae Curriculum vitae

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Biographical details

Dr. Font has more than 10 years’ experience in structural biology and membrane proteins.His research is focused on determining the structures of biological molecules that will enhance the understanding of important biological processes and lead to the development of novel therapies for diseases.He has established a number of new techniques and pipelines. Including the first eukaryotic membrane protein expression and purification system using insect cells at the Centenary Institute and developed a membrane protein crystallisation pipeline at the discipline of pharmacology at the University of Sydney which resulted in several publications in high impact journals such as Nature Communications. He has also expertise in lipidic cubic phase crystallographyCryo Electron Microscopy.

Current research students

Project title Research student
Structural basis of chloride permeation in the archaeal aspartate transporter, GltPh Ichia CHEN

Selected grants

2015

  • SMS ECR Scheme 2015; Font Sadurni J; University of Sydney/Early Career Researcher.

Selected publications

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Journals

  • Zhou, Q., Reekie, T., Abbassi, R., Indurthi Venkata, D., Font Sadurni, J., Ryan, R., Rendina, L., Munoz, L., Kassiou, M. (2018). Flexible analogues of azaindole DYRK1A inhibitors elicit cytotoxity in glioblastoma cells. Australian Journal of Chemistry, 71(10), 789-797. [More Information]
  • Scopelliti, A., Font Sadurni, J., Vandenberg, R., Boudker, O., Ryan, R. (2018). Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5. Nature Communications, 9(1), 38. [More Information]
  • Zhou, Q., Phoa, A., Abbassi, R., Hoque, M., Reekie, T., Font Sadurni, J., Ryan, R., Stringer, B., Day, B., Johns, T., Munoz, L., Kassiou, M. (2017). Structural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like kinases (CLK) inglioblastoma. Journal of Medicinal Chemistry, 60(5), 2052-2070. [More Information]
  • Kurpiewska, K., Dziubek, K., Katrusiak, A., Font Sadurni, J., Ribo, M., Vilanova, M., Lewinski, K. (2016). Structural investigation of ribonuclease A conformational preferences using high pressure protein crystallography. Chemical Physics, 468, 53-62. [More Information]
  • Taniguchi, R., Kato, H., Font Sadurni, J., Deshpande, C., Wada, M., Ito, K., Ishitani, R., Jormakka, M., Nureki, O. (2015). Outward-and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin. Nature Communications, 6, 1-10. [More Information]
  • Guilfoyle, A., Deshpande, C., Font Sadurni, J., Ash, M., Tourle, S., Schenk, G., Maher, M., Jormakka, M. (2014). A GTPase Chimera Illustrates an Uncoupled Nucleotide Affinity and Release Rate, Providing Insight into the Activation Mechanism. Biophysical Journal, 107(12), L45-L48. [More Information]
  • Wang, K., Grkovic, T., Font Sadurni, J., Bonham, S., Pouwer, R., Bailey, C., Moran, A., Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al (2014). Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth. ACS Chemical Biology, 9(6), 1369-1376. [More Information]
  • Wang, K., Beaumont, K., Otte, N., Font Sadurni, J., Bailey, C., van Geldermalsen, M., Sharp, D., Tiffen, J., Ryan, R., Jormakka, M., Haass, N., Rasko, J., Holst, J. (2014). Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer, 135(5), 1060-1071. [More Information]
  • Ercole, C., Lopez-Alonso, J., Font Sadurni, J., Ribo, M., Vilanova, M., Picone, D., Laurents, D. (2011). Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers. Archives of Biochemistry and Biophysics, 506(2), 123-129. [More Information]
  • Wissmueller, S., Font Sadurni, J., Liew, C., Cram, E., Schroeder, T., Turner, J., Crossley, P., Mackay, J., Matthews, J. (2011). Protein-protein interactions: Analysis of a false positive GST pulldown result. Proteins: Structure, Function, and Bioinformatics, 79(8), 2365-2371. [More Information]
  • Nunez Martin, N., Clifton, M., Funnell, A., Crisbel, A., Hallal, S., Quinlan (nee Edwards), K., Font Sadurni, J., Vandevenne, M., Setiyaputra, S., Pearson, R., Mackay, J., Crossley, P. (2011). The Multi-zinc Finger Protein ZNF217 Contacts DNA through a Two-finger Domain. Journal of Biological Chemistry, 286(44), 38190-38201. [More Information]
  • Mackay, J., Font Sadurni, J., Segal, D. (2011). The prospects for designer single-stranded RNA-binding proteins. Nature Structural and Molecular Biology, 18(3), 256-261. [More Information]
  • Lopez-Alonso, J., Bruix, M., Font Sadurni, J., Ribo, M., Vilanova, M., Jimenez, M., Santoro, J., Gonzalez, C., Laurents, D. (2010). NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping. Journal of the American Chemical Society, 132(5), 1621-1630. [More Information]
  • Marchal, S., Font Sadurni, J., Ribo, M., Vilanova, M., Phillips, R., Lange, R., Torrent, J. (2009). Asymmetric kinetics of protein structural changes. Accounts Of Chemical Research, 42(6), 778-787. [More Information]
  • Lopez-Alonso, J., Diez-Garcia, F., Font Sadurni, J., Ribo, M., Vilanova, M., Scholtz, J., Gonzalez, C., Vottariello, F., Gotte, G., Libonati, M., et al (2009). Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity. Bioconjugate Chemistry, 20(8), 1459-1473. [More Information]
  • Kurpiewska, K., Font Sadurni, J., Ribo, M., Vilanova, M., Lewinski, K. (2009). X-ray crystallographic studies of RNase A variants engineered at the most destabilizing positions of the main hydrophobic core: further insight into protein stability. Proteins: Structure, Function, and Bioinformatics, 77(3), 658-669. [More Information]

2018

  • Zhou, Q., Reekie, T., Abbassi, R., Indurthi Venkata, D., Font Sadurni, J., Ryan, R., Rendina, L., Munoz, L., Kassiou, M. (2018). Flexible analogues of azaindole DYRK1A inhibitors elicit cytotoxity in glioblastoma cells. Australian Journal of Chemistry, 71(10), 789-797. [More Information]
  • Scopelliti, A., Font Sadurni, J., Vandenberg, R., Boudker, O., Ryan, R. (2018). Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5. Nature Communications, 9(1), 38. [More Information]

2017

  • Zhou, Q., Phoa, A., Abbassi, R., Hoque, M., Reekie, T., Font Sadurni, J., Ryan, R., Stringer, B., Day, B., Johns, T., Munoz, L., Kassiou, M. (2017). Structural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like kinases (CLK) inglioblastoma. Journal of Medicinal Chemistry, 60(5), 2052-2070. [More Information]

2016

  • Kurpiewska, K., Dziubek, K., Katrusiak, A., Font Sadurni, J., Ribo, M., Vilanova, M., Lewinski, K. (2016). Structural investigation of ribonuclease A conformational preferences using high pressure protein crystallography. Chemical Physics, 468, 53-62. [More Information]

2015

  • Taniguchi, R., Kato, H., Font Sadurni, J., Deshpande, C., Wada, M., Ito, K., Ishitani, R., Jormakka, M., Nureki, O. (2015). Outward-and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin. Nature Communications, 6, 1-10. [More Information]

2014

  • Guilfoyle, A., Deshpande, C., Font Sadurni, J., Ash, M., Tourle, S., Schenk, G., Maher, M., Jormakka, M. (2014). A GTPase Chimera Illustrates an Uncoupled Nucleotide Affinity and Release Rate, Providing Insight into the Activation Mechanism. Biophysical Journal, 107(12), L45-L48. [More Information]
  • Wang, K., Grkovic, T., Font Sadurni, J., Bonham, S., Pouwer, R., Bailey, C., Moran, A., Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al (2014). Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth. ACS Chemical Biology, 9(6), 1369-1376. [More Information]
  • Wang, K., Beaumont, K., Otte, N., Font Sadurni, J., Bailey, C., van Geldermalsen, M., Sharp, D., Tiffen, J., Ryan, R., Jormakka, M., Haass, N., Rasko, J., Holst, J. (2014). Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer, 135(5), 1060-1071. [More Information]

2011

  • Ercole, C., Lopez-Alonso, J., Font Sadurni, J., Ribo, M., Vilanova, M., Picone, D., Laurents, D. (2011). Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers. Archives of Biochemistry and Biophysics, 506(2), 123-129. [More Information]
  • Wissmueller, S., Font Sadurni, J., Liew, C., Cram, E., Schroeder, T., Turner, J., Crossley, P., Mackay, J., Matthews, J. (2011). Protein-protein interactions: Analysis of a false positive GST pulldown result. Proteins: Structure, Function, and Bioinformatics, 79(8), 2365-2371. [More Information]
  • Nunez Martin, N., Clifton, M., Funnell, A., Crisbel, A., Hallal, S., Quinlan (nee Edwards), K., Font Sadurni, J., Vandevenne, M., Setiyaputra, S., Pearson, R., Mackay, J., Crossley, P. (2011). The Multi-zinc Finger Protein ZNF217 Contacts DNA through a Two-finger Domain. Journal of Biological Chemistry, 286(44), 38190-38201. [More Information]
  • Mackay, J., Font Sadurni, J., Segal, D. (2011). The prospects for designer single-stranded RNA-binding proteins. Nature Structural and Molecular Biology, 18(3), 256-261. [More Information]

2010

  • Lopez-Alonso, J., Bruix, M., Font Sadurni, J., Ribo, M., Vilanova, M., Jimenez, M., Santoro, J., Gonzalez, C., Laurents, D. (2010). NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping. Journal of the American Chemical Society, 132(5), 1621-1630. [More Information]

2009

  • Marchal, S., Font Sadurni, J., Ribo, M., Vilanova, M., Phillips, R., Lange, R., Torrent, J. (2009). Asymmetric kinetics of protein structural changes. Accounts Of Chemical Research, 42(6), 778-787. [More Information]
  • Lopez-Alonso, J., Diez-Garcia, F., Font Sadurni, J., Ribo, M., Vilanova, M., Scholtz, J., Gonzalez, C., Vottariello, F., Gotte, G., Libonati, M., et al (2009). Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity. Bioconjugate Chemistry, 20(8), 1459-1473. [More Information]
  • Kurpiewska, K., Font Sadurni, J., Ribo, M., Vilanova, M., Lewinski, K. (2009). X-ray crystallographic studies of RNase A variants engineered at the most destabilizing positions of the main hydrophobic core: further insight into protein stability. Proteins: Structure, Function, and Bioinformatics, 77(3), 658-669. [More Information]

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