Dr Joyce Chiu

https://orcid.org/0000-0001-8910-8664
Research Fellow

Member of the Charles Perkins Centre


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Biographical details

Dr Joyce Chiu is a Sydney Medical School Foundation Fellow at the ACRF Centenary Cancer Research Centre.She studies a fundamental mechanism of protein regulation by a chemical bond known as disulphide bond. Dr Chiu applies her resaerchin the areas of cancer, blood coagulation and immunity.Her research has been published in top journals of her field includingeLife, Nature Communications, Trends in Cell Biology, Nucleic Acids Research, and Blood.Her contribution in the field of cancer research has won the Helen and Robert Ellis Fellowship from the Sydney Medical School Foundation (2017-2019).

Research interests

Disulphide bonds is a chemical bond between two cysteine residues. Traditionally disulphide bonds are considered as structural bond to stabilise protein conformation and are inert. Emerging evidence indicate that a class of disulphide bonds known as functional disulphide bonds mediate changes in protein function (localisation, activity, ligand affinity, etc), These disulphide bonds are molecular switches in the proteins they reside and allows versatile control of protein functions. Many proteins including those implicated in cancer (MetAP2, VEGFc) and blood clotting factors (vWF, Glycoprotein IIb/IIIa) have been shown to have disulpide switches. Dr Chiu employs bioinformatics, proteomics, biochemsitry and biophysics to elucidate novel control of proteins by disulphide bonds.

Current research students

Project title Research student
Characterisation and targeting of glucose metabolism in brain tumours. Reichelle YEO

Current projects

1. Regulation of glucose metabolism in brain cancer

2. Redox regulation of coagulation factors in thrombosis

Associations

2016 - present Sydney Catalyst member

2007- present Australian Society for Biochemistry and Molecular Biology (ASBMB) Ordinary member

In the media

https://twitter.com/CentenaryInst/status/1023757240153436160

Selected grants

2018

  • Towards a novel 'mechanomedicine' against the sticky clot problem of diabetes by targeting oxidoreductase ERp5; Chiu J, Ju L; Charles Perkins Centre/Early-Mid Career Researcher Seed Funding grant.
  • ERp5 is essential to thrombosis; Chiu J; Sydney Medical School/Professor Tony Basten Fellowship in Medical Genetics and Molecular Biology.

2017

  • Metabolic reprogramming in cancer cells through thioredoxin activation of Akt1; Chiu J; Sydney Medical School Foundation/Helen and Robert Ellis Fellowship.

Selected publications

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Journals

  • Pijning, A., Chiu, J., Yeo, R., Wong, J., Hogg, P. (2018). Identification of allosteric disulfides from labile bonds in X-ray structures. Royal Society Open Science, 5(2), 1-13. [More Information]
  • Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., Hogg, P., et al (2018). Mechano-redox control of integrin de-adhesion. eLife, 7, 1-22. [More Information]
  • Bekendam, R., Bendapudi, P., Lin, L., Nag, P., Pu, J., Kennedy, D., Feldenzer, A., Chiu, J., Cook, K., Furie, B., Hogg, P., et al (2016). A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications, 7, 1-11. [More Information]
  • Chiu, J., Passam, F., Butera, D., Hogg, P. (2015). Protein Disulfide Isomerase in Thrombosis. Seminars in Thrombosis and Hemostasis, 41(7), 765-773. [More Information]
  • Butera, D., Cook, K., Chiu, J., Wong, J., Hogg, P. (2014). Control of blood proteins by functional disulfide bonds. Blood, 123(13), 2000-2007. [More Information]
  • Chiu, J., Wong, J., Gerometta, M., Hogg, P. (2014). Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C. Biochemistry, 53(1), 7-9. [More Information]
  • Chiu, J., Wong, J., Hogg, P. (2014). Redox Regulation of Methionine Aminopeptidase 2 Activity. Journal of Biological Chemistry, 289(21), 15035-15043. [More Information]
  • Ng, J., Chiu, J., Hogg, P., Wong, J. (2013). Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. Biochemical and Biophysical Research Communications, 440(1), 37-42. [More Information]
  • Chiu, J., Dawes, I. (2012). Redox control of cell proliferation. Trends in Cell Biology, 22(11), 592-601. [More Information]
  • Park, D., Chiu, J., Perrone, G., Dilda, P., Hogg, P. (2012). The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell International, 12(1), 1-6. [More Information]
  • Chiu, J., Tactacan, C., Tan, S., Lin, R., Wouters, M., Dawes, I. (2011). Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p. Journal of Biological Chemistry, 286(7), 5204-5214. [More Information]

2018

  • Pijning, A., Chiu, J., Yeo, R., Wong, J., Hogg, P. (2018). Identification of allosteric disulfides from labile bonds in X-ray structures. Royal Society Open Science, 5(2), 1-13. [More Information]
  • Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., Hogg, P., et al (2018). Mechano-redox control of integrin de-adhesion. eLife, 7, 1-22. [More Information]

2016

  • Bekendam, R., Bendapudi, P., Lin, L., Nag, P., Pu, J., Kennedy, D., Feldenzer, A., Chiu, J., Cook, K., Furie, B., Hogg, P., et al (2016). A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications, 7, 1-11. [More Information]

2015

  • Chiu, J., Passam, F., Butera, D., Hogg, P. (2015). Protein Disulfide Isomerase in Thrombosis. Seminars in Thrombosis and Hemostasis, 41(7), 765-773. [More Information]

2014

  • Butera, D., Cook, K., Chiu, J., Wong, J., Hogg, P. (2014). Control of blood proteins by functional disulfide bonds. Blood, 123(13), 2000-2007. [More Information]
  • Chiu, J., Wong, J., Gerometta, M., Hogg, P. (2014). Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C. Biochemistry, 53(1), 7-9. [More Information]
  • Chiu, J., Wong, J., Hogg, P. (2014). Redox Regulation of Methionine Aminopeptidase 2 Activity. Journal of Biological Chemistry, 289(21), 15035-15043. [More Information]

2013

  • Ng, J., Chiu, J., Hogg, P., Wong, J. (2013). Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. Biochemical and Biophysical Research Communications, 440(1), 37-42. [More Information]

2012

  • Chiu, J., Dawes, I. (2012). Redox control of cell proliferation. Trends in Cell Biology, 22(11), 592-601. [More Information]
  • Park, D., Chiu, J., Perrone, G., Dilda, P., Hogg, P. (2012). The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell International, 12(1), 1-6. [More Information]

2011

  • Chiu, J., Tactacan, C., Tan, S., Lin, R., Wouters, M., Dawes, I. (2011). Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p. Journal of Biological Chemistry, 286(7), 5204-5214. [More Information]

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