Dr Joyce Chiu

https://orcid.org/0000-0001-8910-8664
Research Fellow

Member of the Charles Perkins Centre


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Biographical details

Dr Joyce Chiu is a Sydney Medical School Foundation Fellow at the ACRF Centenary Cancer Research Centre.She studies how the function of proteins are regulated by redox switches such as disulphide bonds and cysteine oxidation. Dr Chiu's applies her research incancer, blood coagulation and immunity.Her research has been published in top journals of her field including eLife, Nature Communications, Circulation, Trends in Cell Biology, Nucleic Acids Research, and Blood. Her contribution in the field of cancer research has won the Helen and Robert Ellis Fellowship from the Sydney Medical School Foundation (2017-2019).

Research interests

Disulphide bonds is a chemical bond between two cysteine residues. Traditionally disulphide bonds are considered as structural bond to stabilise protein conformation and are inert. Emerging evidence indicate that a class of disulphide bonds known as functional disulphide bonds mediate changes in protein function (localisation, activity, ligand affinity, etc), These disulphide bonds are molecular switches in the proteins they reside and allows versatile control of protein functions. Many proteins including those implicated in cancer (MetAP2, VEGFc) and blood clotting factors (vWF, Glycoprotein IIb/IIIa) have been shown to have disulpide switches. Dr Chiu employs bioinformatics, proteomics, biochemsitry, microfluidics, and single-molecule force spectroscopy to elucidate novel control of proteins by disulphide bonds.

Current research students

Project title Research student
Redox regulation of platelet integrin function Aster PIJNING
Characterisation and targeting of glucose metabolism in brain tumours. Reichelle YEO

Current projects

1. Mechano-redox regulation of integrins

Associations

2018 Australian Society of Biophysics

2016 - present Sydney Catalyst member

2007- present Australian Society for Biochemistry and Molecular Biology (ASBMB) Ordinary member

In the media

https://twitter.com/CentenaryInst/status/1023757240153436160

International links

United States

(Harvard University) Investigation of the function of vascular thiol isomerases in thrombosis

United States

(University of Illinois) Investigation of PDI activity in thromboinflammation

Selected grants

2018

  • Towards a novel 'mechanomedicine' against the sticky clot problem of diabetes by targeting oxidoreductase ERp5; Chiu J, Ju L; Charles Perkins Centre/Early-Mid Career Researcher Seed Funding grant.
  • ERp5 is essential to thrombosis; Chiu J; Sydney Medical School/Professor Tony Basten Fellowship in Medical Genetics and Molecular Biology.

2017

  • Metabolic reprogramming in cancer cells through thioredoxin activation of Akt1; Chiu J; Sydney Medical School Foundation/Helen and Robert Ellis Fellowship.

Selected publications

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Journals

  • Pijning, A., Chiu, J., Yeo, R., Wong, J., Hogg, P. (2018). Identification of allosteric disulfides from labile bonds in X-ray structures. Royal Society Open Science, 5(2), 1-13. [More Information]
  • Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., Hogg, P., et al (2018). Mechano-redox control of integrin de-adhesion. eLife, 7, 1-22. [More Information]
  • Bekendam, R., Iyu, D., Passam, F., Stopa, J., De Ceunynck, K., Muse, O., Bendapudi, P., Garnier, C., Gopal, S., Chiu, J., Hogg, P., et al (2018). Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation. Journal of Thrombosis and Haemostasis, 16(11), 2322-2335. [More Information]
  • Bekendam, R., Bendapudi, P., Lin, L., Nag, P., Pu, J., Kennedy, D., Feldenzer, A., Chiu, J., Cook, K., Furie, B., Hogg, P., et al (2016). A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications, 7, 1-11. [More Information]
  • Chiu, J., Passam, F., Butera, D., Hogg, P. (2015). Protein Disulfide Isomerase in Thrombosis. Seminars in Thrombosis and Hemostasis, 41(7), 765-773. [More Information]
  • Butera, D., Cook, K., Chiu, J., Wong, J., Hogg, P. (2014). Control of blood proteins by functional disulfide bonds. Blood, 123(13), 2000-2007. [More Information]
  • Chiu, J., Wong, J., Gerometta, M., Hogg, P. (2014). Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C. Biochemistry, 53(1), 7-9. [More Information]
  • Chiu, J., Wong, J., Hogg, P. (2014). Redox Regulation of Methionine Aminopeptidase 2 Activity. Journal of Biological Chemistry, 289(21), 15035-15043. [More Information]
  • Ng, J., Chiu, J., Hogg, P., Wong, J. (2013). Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. Biochemical and Biophysical Research Communications, 440(1), 37-42. [More Information]
  • Chiu, J., Dawes, I. (2012). Redox control of cell proliferation. Trends in Cell Biology, 22(11), 592-601. [More Information]
  • Park, D., Chiu, J., Perrone, G., Dilda, P., Hogg, P. (2012). The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell International, 12(1), 1-6. [More Information]
  • Chiu, J., Tactacan, C., Tan, S., Lin, R., Wouters, M., Dawes, I. (2011). Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p. Journal of Biological Chemistry, 286(7), 5204-5214. [More Information]

2018

  • Pijning, A., Chiu, J., Yeo, R., Wong, J., Hogg, P. (2018). Identification of allosteric disulfides from labile bonds in X-ray structures. Royal Society Open Science, 5(2), 1-13. [More Information]
  • Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., Hogg, P., et al (2018). Mechano-redox control of integrin de-adhesion. eLife, 7, 1-22. [More Information]
  • Bekendam, R., Iyu, D., Passam, F., Stopa, J., De Ceunynck, K., Muse, O., Bendapudi, P., Garnier, C., Gopal, S., Chiu, J., Hogg, P., et al (2018). Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation. Journal of Thrombosis and Haemostasis, 16(11), 2322-2335. [More Information]

2016

  • Bekendam, R., Bendapudi, P., Lin, L., Nag, P., Pu, J., Kennedy, D., Feldenzer, A., Chiu, J., Cook, K., Furie, B., Hogg, P., et al (2016). A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications, 7, 1-11. [More Information]

2015

  • Chiu, J., Passam, F., Butera, D., Hogg, P. (2015). Protein Disulfide Isomerase in Thrombosis. Seminars in Thrombosis and Hemostasis, 41(7), 765-773. [More Information]

2014

  • Butera, D., Cook, K., Chiu, J., Wong, J., Hogg, P. (2014). Control of blood proteins by functional disulfide bonds. Blood, 123(13), 2000-2007. [More Information]
  • Chiu, J., Wong, J., Gerometta, M., Hogg, P. (2014). Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C. Biochemistry, 53(1), 7-9. [More Information]
  • Chiu, J., Wong, J., Hogg, P. (2014). Redox Regulation of Methionine Aminopeptidase 2 Activity. Journal of Biological Chemistry, 289(21), 15035-15043. [More Information]

2013

  • Ng, J., Chiu, J., Hogg, P., Wong, J. (2013). Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. Biochemical and Biophysical Research Communications, 440(1), 37-42. [More Information]

2012

  • Chiu, J., Dawes, I. (2012). Redox control of cell proliferation. Trends in Cell Biology, 22(11), 592-601. [More Information]
  • Park, D., Chiu, J., Perrone, G., Dilda, P., Hogg, P. (2012). The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell International, 12(1), 1-6. [More Information]

2011

  • Chiu, J., Tactacan, C., Tan, S., Lin, R., Wouters, M., Dawes, I. (2011). Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p. Journal of Biological Chemistry, 286(7), 5204-5214. [More Information]

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