Dr John-Sebastian Eden

Senior Research Fellow
Sydney Medical School Institutes / Westmead Institute for Medical Research

Member of the Charles Perkins Centre

Telephone +61 2 8627 1817

Website Google Scholar
Level 6 - Westmead Institute for Medical Research
Curriculum vitae Curriculum vitae

Map

Biographical details

Dr John-Sebastian Eden is Research Scientist in Bioinformatics and Genomics based at the Westmead Insitute for Medical Research and Senior Research Fellow in the Sydney Medical School. Dr Eden is a Virologist, who joined the University of Sydney in 2013 with a post-doctoral position in the research group of Professor Eddie Holmes and supported by an NHMRC early career fellowship. Dr Eden has a strong background in viral genome sequencing and analysis, including the application of next-generation sequencing protocols and state-of-the-art bioinformatics methods.

Research interests

The evolutionary mechanisms that drive pathogen emergence and spread.This work combines high-throughput sequencing and comparative genomics to explore the patterns of genetic variation, evolution and molecular epidemiology of clinically important viruses including norovirus, influenza virus and respiratory syncytial virus, as well as, other zoonotic and vector-borne diseases such as ross river virus. The aim of this research is to provide insights into the sources and mechanisms of how viral pathogens emerge, spread and evolve, not only at population scales but also within individual hosts, particularly in the context of infections in immunocompromised hosts. Another important focus of this research has been to better define the link between virus genetics (genotype) and infection outcome (phenotype) including the evolution of important traits such as virulence, drug-resistance and host range.

Unbiased sequencing for pathogen discovery.Recent work has focused on the application of meta-transcriptomics (total RNA sequencing) for pathogen discovery particularly in complex, undiagnosed human infections and in neglected wildlife disease outbreaks. The aim of this research is to develop robust sampling, sequencing and analytical approaches that can provide an unbiased snapshot of all microorganisms (virus, bacteria, fungi or parasite) present in a sample to aid in the diagnoses of infectious diseases, better understand microbial interactions and discovery new microbial diversity. A priority for this work is in the development of novel computational approaches to sort and annotate complex metagenomic datasets, so keen and interested bioinformatics students are encouraged to get in touch about joining the group.

Current projects

  • The evolution and molecular epidemiology of respiratory syncytial virus in Australia
  • Revealing transmission networks using genomics for viral respiratory infections
  • Metatranscriptomics for pathogen discovery
  • Bioinformatics and computational methods in pathogen genomics

A number of positions are avilable for honours and HDR students in 2019 including some with scholarships (http://sydney.edu.au/scholarships/research/faculty/medicine.shtml#SC2663). Please email if you are interested in working on any of these projects (js.eden@sydney.edu.au).

Associations

  • Centre for Virus Research at the Westmead Institute for Medical Reseach
  • Marie Bashir Institute for Infectious Diseases and Biosecurity
  • Biology Domain at the Charles Perkins Centre
  • Professional member of the Australian Society for Microbiology

Awards and honours

  • NHMRC Peter Doherty Early Career Fellowship (2014-18)

In the media

Selected grants

2019

  • Centre for Pathogen Discovery; Holmes E, Shi M, Eden J, Sintchenko V, Lo N, Barrs V, Beatty J, Hudson B, Rose K, Rockett R; DVC Research/Sydney Research Excellence Initiative 2020 (SREI).

2017

  • Centre for Pathogen Discovery; Holmes E, Sintchenko V, Lo N, Shi M, Eden J, Hudson B; DVC Research/Sydney Research Excellence Initiative 2020 (SREI).

2014

  • Integrating genotype and phenotype in clinical molecular epidemiology; Eden J; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Cobbin, J., Britton, P., Burrell, R., Thosar, D., Selvakumar, K., Eden, J., Jones, C., Holmes, E. (2018). A complex mosaic of enteroviruses shapes community-acquired hand, foot and mouth disease transmission and evolution within a single hospital. Virus Evolution, 4(2), 1-11. [More Information]
  • Qi, W., Jia, W., Liu, D., Li, J., Bi, Y., Xie, S., Li, B., Hu, T., Du, Y., Eden, J., Holmes, E., et al (2018). Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor. Journal of Virology, 92(2), 1-12. [More Information]
  • Lun, J., Hewitt, J., Sitabkhan, A., Eden, J., Enosi, T., Netzler, N., Morrell, L., Merif, J., Jones, R., Huang, B., Dwyer, D., Kok, J., et al (2018). Emerging recombinant noroviruses identified by clinical and waste water screening. Emerging Microbes & Infections, 7(1), 1-14. [More Information]
  • Di Giallonardo, F., Kok, J., Fernandez, M., Carter, I., Geoghegan, J., Dwyer, D., Holmes, E., Eden, J. (2018). Evolution of human respiratory syncytial virus (RSV) over multiple seasons in New South Wales, Australia. Viruses, 10(9), 1-13. [More Information]
  • Shi, M., White, V., Schlub, T., Eden, J., Hoffman, A., Holmes, E. (2018). No detectable effect of Wolbachia wMel on the prevalence and abundance of the RNA virome of Drosophila melanogaster. Proceedings of the Royal Society B: Biological Sciences, 285(1883), 1-10. [More Information]
  • Shi, M., Lin, X., Chen, X., Tian, J., Chen, L., Li, K., Wang, W., Eden, J., Shen, J., Liu, L., Holmes, E., et al (2018). The evolutionary history of vertebrate RNA viruses. Nature, 556(7700), 197-202. [More Information]
  • Patterson Ross, Z., Klunk, J., Fornaciari, G., Giuffra, V., Duchene, S., Duggan, A., Poinar, D., Douglas, M., Eden, J., Holmes, E., et al (2018). The paradox of HBV evolution as revealed from a 16th century mummy. PLoS Pathogens, 14(1), 1-25. [More Information]
  • Pollett, S., Trovao, N., Yi, T., Eden, J., Halpin, R., Bera, J., Das, S., Wentworth, D., Ocana, V., Mendocilla, S., et al (2018). The transmission dynamics and diversity of human metapneumovirus in Peru. Influenza and Other Respiratory Viruses, 12(4), 508-513. [More Information]
  • Russo, A., Eden, J., Tuipulotu, D., Shi, M., Selechnik, D., Shine, R., Rollins, L., Holmes, E., White, P. (2018). Viral Discovery in the Invasive Australian Cane Toad (Rhinella marina) Using Metatranscriptomic and Genomic Approaches. Journal of Virology, 92(17), 1-17. [More Information]
  • Russo, A., Eden, J., Tuipulotu, D., Shi, M., Selechnik, D., Shine, R., Rollins, L., Holmes, E., White, P. (2018). Viral discovery in the invasive Australian cane toad (Rhinella marina) using metatranscriptomic and genomic approaches. Journal of Virology, 92(17), 1-18. [More Information]
  • Geoghegan, J., Pirotta, V., Harvey, E., Smith, A., Buchmann, J., Ostrowski, M., Eden, J., Harcourt, R., Holmes, E. (2018). Virological Sampling of Inaccessible Wildlife with Drones. Viruses, 10(300), 1-7. [More Information]
  • Rose, K., Agius, J., Hall, J., Thompson, P., Eden, J., Srivastava, M., Tiernan, B., Jenkins, C., Phalen, D. (2017). Emergent multisystemic Enterococcus infection threatens endangered Christmas Island reptile populations. PloS One, 12(7), 1-21. [More Information]
  • Eden, J., Rose, K., Ng, J., Shi, M., Wang, Q., Sintchenko, V., Holmes, E. (2017). Francisella tularensis subsp. holarctica in Ringtail Possums, Australia. Emerging Infectious Diseases, 23(7), 1198-1201. [More Information]
  • Kerr, P., Cattadori, I., Rogers, M., Fitch, A., Geber, A., Liu, J., Sim, D., Boag, B., Eden, J., Ghedin, E., Holmes, E., et al (2017). Genomic and phenotypic characterization of myxoma virus from Great Britain reveals multiple evolutionary pathways distinct from those in Australia. PLoS Pathogens, 13(3), e1006252. [More Information]
  • Shi, M., Neville, P., Nicholson, J., Eden, J., Imrie, A., Holmes, E. (2017). High-Resolution Metatranscriptomics Reveals the Ecological Dynamics of Mosquito-Associated RNA Viruses in Western Australia. Journal of Virology, 91(17), e00680-17. [More Information]
  • Hiener, B., Horsburgh, B., Eden, J., Barton, K., Schlub, T., Lee, E., van Stockenstrom, S., Odevall, L., Milush, J., Liegler, T., Palmer, S., et al (2017). Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants. Cell Reports, 21(3), 813-822. [More Information]
  • Eden, J., Chisholm, R., Bull, R., White, P., Holmes, E., Tanaka, M. (2017). Persistent infections in immunocompromised hosts are rarely sources of new pathogen variants. Virus Evolution, 3(2), vex018. [More Information]
  • Le Pendu, J., Abrantes, J., Bertagnoli, S., Guitton, J., Le Gall-Recule, G., Lopes, A., Marchandeau, S., Alda, F., Almeida, T., Celio, A., Eden, J., Mahar, J., et al (2017). Proposal for a unified classification system and nomenclature of lagoviruses. Journal of General Virology, 98(7), 1658-1666. [More Information]
  • Liu, J., Cattadori, I., Sim, D., Eden, J., Holmes, E., Read, A., Kerr, P. (2017). Reverse engineering field isolates of myxoma virus demonstrates that some gene disruptions or losses of function do not explain virulence changes observed in the field. Journal of Virology, 91(20), 1-18. [More Information]
  • Lim, K., Hewitt, J., Sitabkhan, A., Eden, J., Lun, J., Levy, A., Merif, J., Smith, D., Rawlinson, W., White, P. (2016). A Multi-Site Study of Norovirus Molecular Epidemiology in Australia and New Zealand, 2013-2014. PloS One, 11(4), 1-19. [More Information]
  • Mahar, J., Nicholson, L., Eden, J., Duchene, S., Kerr, P., Duckworth, J., Ward, V., Holmes, E., Strive, T. (2016). Benign Rabbit Caliciviruses Exhibit Evolutionary Dynamics Similar to Those of Their Virulent Relatives. Journal of Virology, 90(20), 9317-9329. [More Information]
  • Duchene, S., Duchene, D., Di Giallonardo, F., Eden, J., Geoghegan, J., Holt, K., Ho, S., Holmes, E. (2016). Cross-validation to select Bayesian hierarchical models in phylogenetics. BMC Evolutionary Biology, 16(1), 1-8. [More Information]
  • Shi, M., Lin, X., Tian, J., Chen, L., Chen, X., Li, C., Qin, X., Li, J., Cao, J., Eden, J., Buchmann, J., Holmes, E., et al (2016). Redefining the invertebrate RNA virosphere. Nature, 540(7634), 539-543. [More Information]
  • Eden, J., Kovaliski, J., Duckworth, J., Swain, G., Maher, J., Strive, T., Holmes, E. (2015). Comparative phylodynamics of rabbit hemorrhagic disease virus in Australia and New Zealand. Journal of Virology, 89(18), 9548-9558. [More Information]
  • Alhammad, Y., Maharajh, S., Butcher, R., Eden, J., White, P., Poumbourios, P., Drummer, H. (2015). Longitudinal sequence and functional evolution within glycoprotein E2 in hepatitis C virus genotype 3a infection. PloS One, 10(5), 1-19. [More Information]
  • Eden, J., Read, A., Duckworth, J., Strive, T., Holmes, E. (2015). Resolving the Origin of Rabbit Hemorrhagic Disease Virus: Insights from an Investigation of the Viral Stocks Released in Australia. Journal of Virology, 89(23), 12217-12220. [More Information]
  • Eltahla, A., Lim, K., Eden, J., Kelly, A., Mackenzie, J., White, P. (2014). Nonnucleoside Inhibitors of Norovirus RNA Polymerase: Scaffolds for Rational Drug Design. Antimicrobial Agents and Chemotherapy, 58(6), 3115-3123. [More Information]
  • Eden, J., Hewitt, J., Lim, K., Boni, M., Merif, J., Greening, G., Ratcliff, R., Holmes, E., Tanaka, M., Rawlinson, W., et al (2014). The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012. Virology, 450-451, 106-113. [More Information]
  • Eltahla, A., Lackovic, K., Marquis, C., Eden, J., White, P. (2013). A fluorescence-based high-throughput screen to identify small compound inhibitors of the genotype 3a hepatitis c virus RNA polymerase. Journal of Biomolecular Screening, 18(9), 1027-1034. [More Information]
  • Cui, J., Eden, J., Holmes, E., Wang, L. (2013). Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): Implications for the origin and emergence of Middle East Respiratory Syndrome Coronavirus. Virology Journal, 10, 1-5. [More Information]
  • Eden, J., Kun, L., Lynette, L., White, P. (2013). Molecular epidemiology of norovirus in Singapore, 2004-2011. Journal of Medical Virology, 85(10), 1842-1851. [More Information]
  • Eden, J., Tanaka, M., Boni, M., Rawlinson, W., White, P. (2013). Recombination within the pandemic norovirus GII.4 lineage. Journal of Virology, 87(11), 6270-6282. [More Information]
  • Eden, J., Lim, K., White, P. (2012). Complete genome of the human norovirus GIV.1 strain Lake Macquarie virus. Journal of Virology, 86(18), 10251-10252. [More Information]
  • Bull, R., Eden, J., Luciani, F., McElroy, K., Rawlinson, W., White, P. (2012). Contribution of intra- and interhost dynamics to norovirus evolution. Journal of Virology, 86(6), 3219-3229. [More Information]
  • White, P., Eden, J., Hansman, G. (2012). Molecular epidemiology of noroviruses and sapoviruses and their role in Australian outbreaks of acute gastroenteritis. Microbiology Australia, 33(2), 70-73.
  • Eden, J., Sharpe, L., White, P., Brown, A. (2011). Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt. Journal of Virology, 85(20), 10894-10898. [More Information]
  • Eden, J., Bull, R., Tu, E., McIver, C., Lyon, M., Marshall, J., Smith, D., Musto, J., Rawlinson, W., White, P. (2010). Norovirus GII.4 variant 2006b caused epidemics of acute gastroenteritis in Australia during 2007 and 2008. Journal Of Clinical Virology, 49(4), 265-271. [More Information]
  • Bull, R., Eden, J., Rawlinson, W., White, P. (2010). Rapid evolution of pandemic noroviruses of the GII.4 lineage. PLoS Pathogens, 6(3), 1-10. [More Information]

Conferences

  • Eden, J., Lim, K., Ballouk, R., Rawlinson, W., Tanaka, M., White, P. (2012). Complex patterns of evolution led to the emergence of the current norovirus pandemic GII.4 variant, termed New Orleans 2010. 2012 Asia-Pacific Congress of Medical Virology, Adelaide, South Australia, Australia.
  • Eden, J., Bull, R., White, P. (2011). Evidence of intra-genotype recombination in the evolution of a novel norovirus GII.4 variant associated with outbreaks in NSW, Australia during 2009. Australian Microbiology Society Annual Scientific Meeting.
  • Eden, J., Bull, R., White, P. (2010). Evolution of a novel GII.4 associated with outbreaks of gastroenteritis in NSW, Australia during 2009. International Calicivirus Conference.
  • Eden, J., Bull, R., Tu, E., Lim, H., McIver, C., Lyon, M., Marshall, J., Smith, D., Musto, J., Rawlinson, W., et al (2009). Norovirus GII.4 variant, 2006b, continues to cause gastroenteritis epidemics across Australia in 2007 and 2008. Australian Virology Group Meeting.

2018

  • Cobbin, J., Britton, P., Burrell, R., Thosar, D., Selvakumar, K., Eden, J., Jones, C., Holmes, E. (2018). A complex mosaic of enteroviruses shapes community-acquired hand, foot and mouth disease transmission and evolution within a single hospital. Virus Evolution, 4(2), 1-11. [More Information]
  • Qi, W., Jia, W., Liu, D., Li, J., Bi, Y., Xie, S., Li, B., Hu, T., Du, Y., Eden, J., Holmes, E., et al (2018). Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor. Journal of Virology, 92(2), 1-12. [More Information]
  • Lun, J., Hewitt, J., Sitabkhan, A., Eden, J., Enosi, T., Netzler, N., Morrell, L., Merif, J., Jones, R., Huang, B., Dwyer, D., Kok, J., et al (2018). Emerging recombinant noroviruses identified by clinical and waste water screening. Emerging Microbes & Infections, 7(1), 1-14. [More Information]
  • Di Giallonardo, F., Kok, J., Fernandez, M., Carter, I., Geoghegan, J., Dwyer, D., Holmes, E., Eden, J. (2018). Evolution of human respiratory syncytial virus (RSV) over multiple seasons in New South Wales, Australia. Viruses, 10(9), 1-13. [More Information]
  • Shi, M., White, V., Schlub, T., Eden, J., Hoffman, A., Holmes, E. (2018). No detectable effect of Wolbachia wMel on the prevalence and abundance of the RNA virome of Drosophila melanogaster. Proceedings of the Royal Society B: Biological Sciences, 285(1883), 1-10. [More Information]
  • Shi, M., Lin, X., Chen, X., Tian, J., Chen, L., Li, K., Wang, W., Eden, J., Shen, J., Liu, L., Holmes, E., et al (2018). The evolutionary history of vertebrate RNA viruses. Nature, 556(7700), 197-202. [More Information]
  • Patterson Ross, Z., Klunk, J., Fornaciari, G., Giuffra, V., Duchene, S., Duggan, A., Poinar, D., Douglas, M., Eden, J., Holmes, E., et al (2018). The paradox of HBV evolution as revealed from a 16th century mummy. PLoS Pathogens, 14(1), 1-25. [More Information]
  • Pollett, S., Trovao, N., Yi, T., Eden, J., Halpin, R., Bera, J., Das, S., Wentworth, D., Ocana, V., Mendocilla, S., et al (2018). The transmission dynamics and diversity of human metapneumovirus in Peru. Influenza and Other Respiratory Viruses, 12(4), 508-513. [More Information]
  • Russo, A., Eden, J., Tuipulotu, D., Shi, M., Selechnik, D., Shine, R., Rollins, L., Holmes, E., White, P. (2018). Viral Discovery in the Invasive Australian Cane Toad (Rhinella marina) Using Metatranscriptomic and Genomic Approaches. Journal of Virology, 92(17), 1-17. [More Information]
  • Russo, A., Eden, J., Tuipulotu, D., Shi, M., Selechnik, D., Shine, R., Rollins, L., Holmes, E., White, P. (2018). Viral discovery in the invasive Australian cane toad (Rhinella marina) using metatranscriptomic and genomic approaches. Journal of Virology, 92(17), 1-18. [More Information]
  • Geoghegan, J., Pirotta, V., Harvey, E., Smith, A., Buchmann, J., Ostrowski, M., Eden, J., Harcourt, R., Holmes, E. (2018). Virological Sampling of Inaccessible Wildlife with Drones. Viruses, 10(300), 1-7. [More Information]

2017

  • Rose, K., Agius, J., Hall, J., Thompson, P., Eden, J., Srivastava, M., Tiernan, B., Jenkins, C., Phalen, D. (2017). Emergent multisystemic Enterococcus infection threatens endangered Christmas Island reptile populations. PloS One, 12(7), 1-21. [More Information]
  • Eden, J., Rose, K., Ng, J., Shi, M., Wang, Q., Sintchenko, V., Holmes, E. (2017). Francisella tularensis subsp. holarctica in Ringtail Possums, Australia. Emerging Infectious Diseases, 23(7), 1198-1201. [More Information]
  • Kerr, P., Cattadori, I., Rogers, M., Fitch, A., Geber, A., Liu, J., Sim, D., Boag, B., Eden, J., Ghedin, E., Holmes, E., et al (2017). Genomic and phenotypic characterization of myxoma virus from Great Britain reveals multiple evolutionary pathways distinct from those in Australia. PLoS Pathogens, 13(3), e1006252. [More Information]
  • Shi, M., Neville, P., Nicholson, J., Eden, J., Imrie, A., Holmes, E. (2017). High-Resolution Metatranscriptomics Reveals the Ecological Dynamics of Mosquito-Associated RNA Viruses in Western Australia. Journal of Virology, 91(17), e00680-17. [More Information]
  • Hiener, B., Horsburgh, B., Eden, J., Barton, K., Schlub, T., Lee, E., van Stockenstrom, S., Odevall, L., Milush, J., Liegler, T., Palmer, S., et al (2017). Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants. Cell Reports, 21(3), 813-822. [More Information]
  • Eden, J., Chisholm, R., Bull, R., White, P., Holmes, E., Tanaka, M. (2017). Persistent infections in immunocompromised hosts are rarely sources of new pathogen variants. Virus Evolution, 3(2), vex018. [More Information]
  • Le Pendu, J., Abrantes, J., Bertagnoli, S., Guitton, J., Le Gall-Recule, G., Lopes, A., Marchandeau, S., Alda, F., Almeida, T., Celio, A., Eden, J., Mahar, J., et al (2017). Proposal for a unified classification system and nomenclature of lagoviruses. Journal of General Virology, 98(7), 1658-1666. [More Information]
  • Liu, J., Cattadori, I., Sim, D., Eden, J., Holmes, E., Read, A., Kerr, P. (2017). Reverse engineering field isolates of myxoma virus demonstrates that some gene disruptions or losses of function do not explain virulence changes observed in the field. Journal of Virology, 91(20), 1-18. [More Information]

2016

  • Lim, K., Hewitt, J., Sitabkhan, A., Eden, J., Lun, J., Levy, A., Merif, J., Smith, D., Rawlinson, W., White, P. (2016). A Multi-Site Study of Norovirus Molecular Epidemiology in Australia and New Zealand, 2013-2014. PloS One, 11(4), 1-19. [More Information]
  • Mahar, J., Nicholson, L., Eden, J., Duchene, S., Kerr, P., Duckworth, J., Ward, V., Holmes, E., Strive, T. (2016). Benign Rabbit Caliciviruses Exhibit Evolutionary Dynamics Similar to Those of Their Virulent Relatives. Journal of Virology, 90(20), 9317-9329. [More Information]
  • Duchene, S., Duchene, D., Di Giallonardo, F., Eden, J., Geoghegan, J., Holt, K., Ho, S., Holmes, E. (2016). Cross-validation to select Bayesian hierarchical models in phylogenetics. BMC Evolutionary Biology, 16(1), 1-8. [More Information]
  • Shi, M., Lin, X., Tian, J., Chen, L., Chen, X., Li, C., Qin, X., Li, J., Cao, J., Eden, J., Buchmann, J., Holmes, E., et al (2016). Redefining the invertebrate RNA virosphere. Nature, 540(7634), 539-543. [More Information]

2015

  • Eden, J., Kovaliski, J., Duckworth, J., Swain, G., Maher, J., Strive, T., Holmes, E. (2015). Comparative phylodynamics of rabbit hemorrhagic disease virus in Australia and New Zealand. Journal of Virology, 89(18), 9548-9558. [More Information]
  • Alhammad, Y., Maharajh, S., Butcher, R., Eden, J., White, P., Poumbourios, P., Drummer, H. (2015). Longitudinal sequence and functional evolution within glycoprotein E2 in hepatitis C virus genotype 3a infection. PloS One, 10(5), 1-19. [More Information]
  • Eden, J., Read, A., Duckworth, J., Strive, T., Holmes, E. (2015). Resolving the Origin of Rabbit Hemorrhagic Disease Virus: Insights from an Investigation of the Viral Stocks Released in Australia. Journal of Virology, 89(23), 12217-12220. [More Information]

2014

  • Eltahla, A., Lim, K., Eden, J., Kelly, A., Mackenzie, J., White, P. (2014). Nonnucleoside Inhibitors of Norovirus RNA Polymerase: Scaffolds for Rational Drug Design. Antimicrobial Agents and Chemotherapy, 58(6), 3115-3123. [More Information]
  • Eden, J., Hewitt, J., Lim, K., Boni, M., Merif, J., Greening, G., Ratcliff, R., Holmes, E., Tanaka, M., Rawlinson, W., et al (2014). The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012. Virology, 450-451, 106-113. [More Information]

2013

  • Eltahla, A., Lackovic, K., Marquis, C., Eden, J., White, P. (2013). A fluorescence-based high-throughput screen to identify small compound inhibitors of the genotype 3a hepatitis c virus RNA polymerase. Journal of Biomolecular Screening, 18(9), 1027-1034. [More Information]
  • Cui, J., Eden, J., Holmes, E., Wang, L. (2013). Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): Implications for the origin and emergence of Middle East Respiratory Syndrome Coronavirus. Virology Journal, 10, 1-5. [More Information]
  • Eden, J., Kun, L., Lynette, L., White, P. (2013). Molecular epidemiology of norovirus in Singapore, 2004-2011. Journal of Medical Virology, 85(10), 1842-1851. [More Information]
  • Eden, J., Tanaka, M., Boni, M., Rawlinson, W., White, P. (2013). Recombination within the pandemic norovirus GII.4 lineage. Journal of Virology, 87(11), 6270-6282. [More Information]

2012

  • Eden, J., Lim, K., White, P. (2012). Complete genome of the human norovirus GIV.1 strain Lake Macquarie virus. Journal of Virology, 86(18), 10251-10252. [More Information]
  • Eden, J., Lim, K., Ballouk, R., Rawlinson, W., Tanaka, M., White, P. (2012). Complex patterns of evolution led to the emergence of the current norovirus pandemic GII.4 variant, termed New Orleans 2010. 2012 Asia-Pacific Congress of Medical Virology, Adelaide, South Australia, Australia.
  • Bull, R., Eden, J., Luciani, F., McElroy, K., Rawlinson, W., White, P. (2012). Contribution of intra- and interhost dynamics to norovirus evolution. Journal of Virology, 86(6), 3219-3229. [More Information]
  • White, P., Eden, J., Hansman, G. (2012). Molecular epidemiology of noroviruses and sapoviruses and their role in Australian outbreaks of acute gastroenteritis. Microbiology Australia, 33(2), 70-73.

2011

  • Eden, J., Bull, R., White, P. (2011). Evidence of intra-genotype recombination in the evolution of a novel norovirus GII.4 variant associated with outbreaks in NSW, Australia during 2009. Australian Microbiology Society Annual Scientific Meeting.
  • Eden, J., Sharpe, L., White, P., Brown, A. (2011). Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt. Journal of Virology, 85(20), 10894-10898. [More Information]

2010

  • Eden, J., Bull, R., White, P. (2010). Evolution of a novel GII.4 associated with outbreaks of gastroenteritis in NSW, Australia during 2009. International Calicivirus Conference.
  • Eden, J., Bull, R., Tu, E., McIver, C., Lyon, M., Marshall, J., Smith, D., Musto, J., Rawlinson, W., White, P. (2010). Norovirus GII.4 variant 2006b caused epidemics of acute gastroenteritis in Australia during 2007 and 2008. Journal Of Clinical Virology, 49(4), 265-271. [More Information]
  • Bull, R., Eden, J., Rawlinson, W., White, P. (2010). Rapid evolution of pandemic noroviruses of the GII.4 lineage. PLoS Pathogens, 6(3), 1-10. [More Information]

2009

  • Eden, J., Bull, R., Tu, E., Lim, H., McIver, C., Lyon, M., Marshall, J., Smith, D., Musto, J., Rawlinson, W., et al (2009). Norovirus GII.4 variant, 2006b, continues to cause gastroenteritis epidemics across Australia in 2007 and 2008. Australian Virology Group Meeting.

To update your profile click here. For support on your academic profile contact .