Associate Professor Judy Kirk

Clinical Associate Professor
Medicine, Westmead Clinical School
The Westmead Institute for Medical Research

Cancer research network

Telephone 9845 6947
Fax 9845 9217

Map

Clinical Specialty

Oncology

Selected grants

2015

  • Translating our knowledge of genomics to improve skin cancer prevention: a pilot randomized controlled trial to evaluate whether knowledge of personal genetic risk of melanoma motivates behaviour change; Cust A, Newson A, Kimlin M, Kirk J, Keogh L, Law M, Morton R, Williams G, Butow P, Dobbinson S; DVC Research/SPARC Implementation - Cancer.
  • Evidence-based massively parallel translation: Application to breast cancer susceptibility; Southey M, James P, Tucker K, Kirk J, Trainer A, Winship I, Pachter N; National Breast Cancer Foundation/Accelerator Grant.

2012

  • The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (KconFab - a national and international resource for research into familial breast cancer); Fox S, Kirk J; National Breast Cancer Foundation/Infrastructure Grant.

2010

  • Randomised trial of consumer-led familiar cancer risk tool & GP triage on risk-appropriate colorectal cancer screening; Trevena L, Meiser B, Meiser B, Kirk J, Barlow-Stewart K, Dobbins T, Goodwin A; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.

2003

  • kConFab: A National Consortium for Research into Familial Breast Cancer.; Kirk J; Cancer Council New South Wales/Research Project Grants.

2002

  • A national consortium for research into familial breast cancer; Kirk J; Cancer Council New South Wales/Research Project Grants.

2000

  • Early events predisposing to breast cancer in women with a genetic susceptibility; Clarke C, Leary J, Balleine R, Kirk J; Leo and Jenny Leukaemia and Cancer Foundation/Leukaemia and Cancer Foundation.
  • Transgenomic WAVE 2100 denaturing HPLC system for DNA variant analysis; Farrell G, Clarke C, Cunningham A, deFazio A, Kirk J, Leary J, Liddle C, Manolios N, Mitchell P, Stewart G, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Book Chapters

  • Kirk, J. (2010). Genetic Testing for Cancer Susceptibility: How and When? In Monica Robotin, Ian Olver, Afaf Girgis (Eds.), When Cancer Crosses Disciplines: A Physicians Handbook, (pp. 931-939). London: Imperial College Press.
  • Hallett, K., Cameron, A., Widmer, R., King, P., Kilpatrick, N., Wilson, M., Lucas, J., Wong, P., Mekertichian, K., Isaacs, D., Kirk, J., et al (2003). Medically compromised children. In Cameron, Widmer (Eds.), Handbook of Pediatric Dentistry, Second Editions, (pp. 234-286). Australia: Mosby.

Journals

  • Kirk, J., Li, J., Meeks, H., Feng, B., Healey, S., Thorne, H., Makunin, I., Ellis, J., Campbell, I., Southey, M., et al (2016). Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families. Journal of Medical Genetics, 53(1), 34-42. [More Information]
  • Douma, K., Meiser, B., Kirk, J., Mitchell, G., Saunders, C., Rahman, B., Sousa, M., Barlow-Stewart, K., Gleeson, M., Tucker, K. (2015). Health professionals' evaluation of delivering treatment-focused genetic testing to women newly diagnosed with breast cancer. Familial Cancer, 14(2), 265-272. [More Information]
  • Wu, K., Kirk, J. (2015). Hereditary colorectal cancer what you need to know what you need to know. Medicine Today, 16(2), 20-29.
  • Kuchenbaecker, K., Ramus, S., Tyrer, J., Lee, A., Shen, H., Beesley, J., Lawrenson, K., McGuffog, L., Kirk, J., et al (2015). Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nature Genetics, 47(2), 164-171. [More Information]
  • Dunlop, K., Kirk, J., Tucker, K. (2014). In the wake of Angelina - Managing a family history of breast cancer. Australian Family Physician, 43(1-2), 76-78.
  • McBride, K., Ballinger, M., Killick, E., Kirk, J., Tattersall, M., Eeles, R., Thomas, D., Mitchell, G. (2014). Li-Fraumeni syndrome: cancer risk assessment and clinical management. Nature Reviews Clinical Oncology, 11(5), 260-271. [More Information]
  • Wickremeratne, T., Lee, C., Kirk, J., Charlton, A., Thomas, G., Gaskin, K. (2014). Prophylactic gastrectomy in a 16-year-old. European Journal of Gastroenterology and Hepatology, 26(3), 353-356. [More Information]
  • Buchanan, D., Tan, Y., Walsh, M., Clendenning, M., Metcalf, A., Ferguson, K., Arnold, S., Thompson, B., Lose, F., Parsons, M., Kirk, J., et al (2014). Reply to J. Moline et al. Journal of Clinical Oncology, 32(21), 2278-2279. [More Information]
  • Bancroft, E., Page, E., Castro, E., Lilja, H., Vickers, A., Sjoberg, D., Assel, M., Foster, C., Mitchell, G., Kirk, J., et al (2014). Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study. European Urology, 66(3), 489-499. [More Information]
  • Buchanan, D., Tan, Y., Walsh, M., Clendenning, M., Metcalf, A., Ferguson, K., Arnold, S., Thompson, B., Lose, F., Parsons, M., Kirk, J., et al (2014). Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for Population-Level Germline Mismatch Repair Gene Mutation Testing. Journal of Clinical Oncology, 32(2), 90-100. [More Information]
  • Garcia-Closas, M., Couch, F., Lindstrom, S., Michailidou, K., Schmidt, M., Brook, M., Orr, N., Rhie, S., Riboli, E., Feigelson, H., Carpenter, J., Balleine, R., et al (2013). Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nature Genetics, 45(4), 392-398. [More Information]
  • Wakefield, C., Thorne, H., Kirk, J., Niedermayr, E., Doolan, E., Tucker, K. (2013). Improving mutation notification when new genetic information is identified in research: a trial of two strategies in familial breast cancer. Genetics in Medicine, 15(3), 187-194. [More Information]
  • Burcher, S., Meiser, B., Mitchell, G., Saunders, C., Rahman, B., Tucker, K., Barlow-Stewart, K., Watts, K., Gleeson, M., Kirk, J. (2013). Oncology health professionals attitudes toward treatment-focused genetic testing for women newly diagnosed with breast cancer. Personalized Medicine, 10(5), 431-440. [More Information]
  • Antoniou, A., Kuchenbaecker, K., Soucy, P., Beesley, J., Chen, X., McGuffog, L., Lee, A., Barrowdale, D., Healey, S., Sinilnikova, O., Kirk, J., et al (2012). Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Research, 14(1), 1-18. [More Information]
  • Meiser, B., Gleeson, M., Watts, K., Peate, M., Zilliacus, E., Barlow-Stewart, K., Saunders, C., Mitchell, G., Kirk, J. (2012). Getting to the Point: What Women Newly Diagnosed with Breast Cancer Want to Know About Treatment-Focused Genetic Testing. Oncology Nursing Forum, 39(2), E101-E111. [More Information]
  • Watts, K., Meiser, B., Mitchell, G., Kirk, J., Saunders, C., Peate, M., Duffy, J., Kelly, P., Gleeson, M., Barlow-Stewart, K., et al (2012). How should we discuss genetic testing with women newly diagnosed with breast cancer? Design and implementation of a randomized controlled trial of two models of delivering education about treatment-focused genetic testing to younger women newly diagnosed with breast cancer. BMC Cancer, 12(1), 1-12. [More Information]
  • Saleh, M., Barlow-Stewart, K., Meiser, B., Tucker, K., Eisenbruch, M., Kirk, J. (2012). Knowledge, attitudes and beliefs of Arabic-Australians concerning cancer. Psycho-Oncology, 21(2), 195-202. [More Information]
  • Saleh, M., Barlow-Stewart, K., Meiser, B., Kirk, J., Tucker, K. (2011). An Exploration of the Cultural Context of Kinship and Genetics Amongst Arabic-Australians: Implications for Practice. Journal of Genetic Counseling, 20(5), 465-475. [More Information]
  • Zilliacus, E., Meiser, B., Lobb, E., Kelly, P., Barlow-Stewart, K., Kirk, J., Spigelman, A., Warwick, L., Tucker, K. (2011). Are videoconferenced consultations as effective as face-to-face consultations for hereditary breast and ovarian cancer genetic counseling? Genetics in Medicine, 13(11), 933-941. [More Information]
  • Mitra, A., Bancroft, E., Barbachano, Y., Page, E., Foster, C., Jameson, C., Mitchell, G., Lindeman, G., Stapleton, A., Suthers, G., Kirk, J., et al (2011). Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study. BJU International, 107(1), 28-39. [More Information]
  • Antill, Y., Mitchell, G., Johnson, S., Devereux, L., Milner, A., Di Iulio, J., Lindeman, G., Kirk, J., Phillips, K., Campbell, I. (2010). Gene Methylation in Breast Ductal Fluid from BRCA1 and BRCA2 Mutation Carriers. Cancer Epidemiology, Biomarkers and Prevention, 19(1), 265-274. [More Information]
  • Whitaker, H., Kote-Jarai, Z., Ross-Adams, H., Warren, A., Burge, J., George, A., Bancroft, E., Jhavar, S., Leongamornlert, D., Tymrakiewicz, M., Kirk, J., et al (2010). The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. PloS One, 5(10), 1-8. [More Information]
  • Zilliacus, E., Meiser, B., Lobb, E., Kirk, J., Warwick, L., Tucker, K. (2010). Women's Experience of Telehealth Cancer Genetic Counseling. Journal of Genetic Counseling, 19(5), 463-472. [More Information]
  • Shanley, S., Fung, C., Milliken, J., Leary, J., Barnetson, R., Schnitzler, M., Kirk, J. (2009). Breast cancer immunohistochemistry can be useful in triage of some HNPCC families. Familial Cancer, 8, 251-255. [More Information]
  • Juan, A., Wakefield, C., Kasparian, N., Kirk, J., Tyler, J., Tucker, K. (2008). Development and Pilot Testing of a Decision Aid for Men Considering Genetic Testing for Breast and/or Ovarian Cancer-Related Mutations (BRCA1/2). Genetic Testing, 12, 523-532. [More Information]
  • Wakefield, C., Meiser, B., Homewood, J., Ward, R., O'Donnell, S., Kirk, J. (2008). Randomized trial of a decision aid for individuals considering genetic testing for hereditary nonpolyposis colorectal cancer risk. Cancer, 113, 956-965. [More Information]
  • Wakefield, C., Meiser, B., Homewood, J., Peate, M., Taylor, A., Lobb, E., Kirk, J., Young, M., Williams, R., Dudding, T., et al (2007). A randomized controlled trial of a decision aid for women considering genetic testing for breast and ovarian cancer risk. Breast Cancer Research and Treatment, 107(2), 289-301. [More Information]
  • Wakefield, C., Kasparian, N., Meiser, B., Homewood, J., Kirk, J., Tucker, K. (2007). Attitudes Toward Genetic Testing for Cancer Risk after Genetic Counseling and Decision Support: A Qualitative Comparison between Hereditary Cancer Types. Genetic Testing, 11(4), 401-412. [More Information]
  • Wakefield, C., Meiser, B., Homewood, J., Peate, M., Kirk, J., Warner, B., Lobb, E., Gaff, C., Tucker, K. (2007). Development and pilot testing of two decision Aids for individuals considering genetic testing for cancer risk. Journal of Genetic Counseling, 16(3), 325-339. [More Information]
  • Featherstone, C., Colley, A., Tucker, K., Kirk, J., Barton, M. (2007). Estimating the referral rate for cancer genetic assessment from a systematic review of the evidence. British Journal of Cancer, 96(2), 391-398.
  • Field, M., Shanley, S., Kirk, J. (2007). Inherited cancer susceptibility syndromes in paediatric practice. Journal of Paediatrics and Child Health, 43(4), 219-229. [More Information]
  • Kirk, J., Suthers, G. (2007). Overview. Cancer Forum, 31(3), 135-138.
  • Kirk, J. (2007). The role of familial Cancer Services. Cancer Forum, 31(3), 136-138.
  • Tiller, K., Meiser, B., Gaff, C., Kirk, J., Dudding, T., Phillips, K., Friedlander, M., Tucker, K. (2006). A randomized controlled trial of a decision aid for women at increased risk of ovarian cancer. Medical Decision Making, 26(4), 360-372. [More Information]
  • Kirk, J., Brennan, M., Houssami, N., Ung, O. (2006). An approach to the patient with a family history of breast cancer. Australian Family Physician, 35(1-2), 43-47. [More Information]
  • Mann, G., Thorne, H., Balleine, R., Butow, P., Clarke, C., Edkins, E., Evans, G., Fereday, S., Haan, E., Gattas, M., Kirk, J., Leary, J., Pupo, G., et al (2006). Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research, 8(1), 1-15. [More Information]
  • Lobb, E., Butow, P., Moore, A., Barratt, A., Tucker, K., Gaff, C., Kirk, J., Dudding, T., Butt, D. (2006). Development of a communication aid to facilitate risk communication in consultations with unaffected women from high risk breast cancer families: A pilot study. Journal of Genetic Counseling, 15(5), 393-405. [More Information]
  • Kang, H., Williams, R., Leary, J., Ringland, C., Kirk, J., Ward, R. (2006). Evaluation of models to predict BRCA germline mutations. British Journal of Cancer, 95(7), 914-920. [More Information]
  • Balleine, R., Murali, R., Bilous, M., Farshid, G., Waring, P., Provan, P., Byth Wilson, K., Thorne, H., KConFab, C., Kirk, J. (2006). Histopathological features of breast cancer in carriers of ATM gene variants. Histopathology, 49. [More Information]
  • Kirk, J. (2006). How can we best detect hereditary non-polyposis colorectal cancer? Medical Journal of Australia, 184(5), 206-207.
  • Antill, Y., Reynolds, J., Young, M., Kirk, J., Tucker, K., Bogtstra, T., Wong, S., Dudding, T., Di Iulio, J., Phillips, K. (2006). Risk-reducing surgery in women with familial susceptibility for breast and/or ovarian cancer. European Journal of Cancer, 42(5), 621-628. [More Information]
  • Antill, Y., Reynolds, J., Young, M., Kirk, J., Tucker, K., Bogtstra, T., Wong, S., Dudding, T., Di Iulio, J., Phillips, K. (2006). Screening behavior in women at increased familial risk for breast cancer. Familial Cancer, 5(4), 359-368. [More Information]
  • Kirk, J. (2006). Who needs Cancer screening. ANZ Journal of Surgery, 76(Supp1), A78.
  • Brennan, M., French, J., Houssami, N., Kirk, J., Boyages, J. (2005). Breast cancer in young women. Australian Family Physician, 34(10), 851-855. [More Information]
  • Woodward, A., Davis, T., Silva, A., KConFab, C., Kirk, J., Leary, J. (2005). Large genomic rearrangements of both BRCA2 and BRCA1 are a feature of the inherited breast/ovarian cancer phenotype in selected families. Journal of Medical Genetics, 42(5), e31-e34. [More Information]
  • Hitchins, M., Williams, R., Cheong, K., Halani, N., Lin, V., Packham, D., Ku, S., Buckle, A., Hawkins, N., Kirk, J., et al (2005). MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology, 129. [More Information]
  • Kairupan, C., Meldrum, C., Crooks, R., Milward, E., Spigelman, A., Burgess, B., Groombridge, C., Kirk, J., Tucker, K., Ward, R., et al (2005). Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations. International Journal of Cancer, 116(1), 73-77. [More Information]
  • Mitchell, G., Antill, Y., Murray, W., Kirk, J., Salisbury, E., Lindeman, G., Di Iulio, J., Milner, A., Devereaux, L., Phillips, K. (2005). Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation. Breast Cancer Research, 7(6), R1122-R1131. [More Information]
  • Weir, L., Spigelman, A., Scott, R., Kirk, J., Zeckendorf, S., Sitas, F. (2005). The NSW & ACT Hereditary Cancer Registers. Australian Family Physician, 34(1-2), 53-58. [More Information]
  • Lindeman, G., Hiew, M., Visvader, J., Leary, J., Field, M., Gaff, C., McKinlay Garnder, R., Trainor, K., Cheetham, G., Suthers, G., Kirk, J. (2004). Frequency Of The Atm Ivs10-6T-->G Variant In Australian Multiple-Case Breast Cancer Families. Breast Cancer Research, 6(4), R401-7.
  • Mote, P., Leary, J., Avery, K., Sandelin, K., Chenevix-Trench, G., kConFab Investigators., Kirk, J., Clarke, C. (2004). Germ-Line Mutations In Brca1 Or Brca2 In The Normal Breast Are Associated With Altered Expression Of Estrogen-Responsive Proteins And The Predominance Of Progesterone Receptor A. Genes Chromosomes and Cancer, 39(3), 236-248. [More Information]
  • Kirk, J. (2004). Letter: Gene silencing. New England Journal of Medicine, 350(9), 947-948.
  • Kirk, J. (2004). Letter: Genetic testing: a round table conversation. Internal Medicine Journal, 34(7), 445.
  • Kirk, J. (2004). The family history of cancer - a common concern in palliative care. Progress in Palliative Care, 12(2), 59-66.
  • Keogh, L., Southey, M., Maskiell, J., Young, M., Gaff, C., Kirk, J., Tucker, K., Rosenthal, D., McCredie, M., Giles, G., et al (2004). Uptake of offer to receive genetic information about BRCA1 and BRCA2 mutations in an Australian population-based study. Cancer Epidemiology, Biomarkers and Prevention, 13(12), 2258-2263.
  • Tiller, K., Meiser, B., Reeson, E., Tucker, M., Andrews, L., Gaff, C., Kirk, J., Phillips, K., Friedlander, M. (2003). A decision aid for women at increased risk for ovarian cancer. International Journal Of Gynecological Cancer, 13(1), 15-22.
  • Fisher, T., Kirk, J., Hopper, J., Godding, R., Burgemeister, F. (2003). A simple tool for identifying unaffected women at a moderately increased or potentially high risk of breast cancer based on their family history. The Breast, 12(2), 120-127.
  • Kirk, J. (2003). How to treat familial cancer. Australian Doctor, , 25-32.
  • Shannon, C., Kirk, J., Barnetson, R., Evans, J., Schnitzler, M., Quinn, M., Hacker, N., Crandon, A., Harnett, P. (2003). Incidence of microsatellite instability in synchronous tumors of the ovary and endometrium. Clinical Cancer Research, 9(4), 1387-1392.
  • Lobb, E., Butow, P., Meiser, B., Barratt, A., Gaff, C., Young, M., Kirk, J., Gattans, M., Gleeson, M., Tucker, K. (2003). Women's preferences and consultants' communication of risk in consultations about familial breast cancer: impact on patient outcomes. Journal of Medical Genetics, 40(5 - e56), 1-8.
  • Chenevix-Trench, G., Spurdle, A., Gatei, M., Kelly, H., Marsh, A., Chen, X., Donn, K., Cummings, M., Nyholt, D., Jenkins, M., Pupo, G., Kirk, J., Tucker, P., Mann, G., et al (2002). Dominant Negative ATM Mutations in Breast Cancer Families. Journal of the National Cancer Institute, 94(3), 205-215.
  • Lobb, E., Butow, P., Meiser, B., Barratt, A., Gaff, C., Young, M., Kirk, J., Suthers, G., Tucker, K. (2002). Tailoring communication in consultations with women from high risk breast cancer families. British Journal of Cancer, 87(5), 502-508.
  • Lobb, E., Butow, P., Meiser, B., Barratt, A., Kirk, J., Gattas, M., Haan, E., Tucker, K. (2002). The use of audiotapes in consultations with women from high risk breast cancer families: a randomised trial. Journal of Medical Genetics, 39(9), 697-703.
  • Scott, R., Meldrum, C., Crooks, R., Spigelman, A., Kirk, J., Tucker, K., Koorey, D., Hunter, F. (2001). Familial adenomatous polyposis: more evidence for disease diversity and genetic heterogeneity. Gut (English Edition): an international journal of gastroenterology and hepatology, 48(4), 508-514.
  • Scott, R., McPhillips, M., Meldrum, C., FitzGerald, P., Adams, K., Spigelman, A., du Sart, D., Tucker, K., Kirk, J. (2001). Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds. American Journal of Human Genetics, 68(1), 118-127.
  • Randall, J., Butow, P., Kirk, J., Tucker, K. (2001). Psychological impact of genetic counselling and testing in women previously diagnosed with breast cancer. Internal Medicine Journal, 31(7), 397-405.
  • Meiser, B., Butow, P., Barratt, A., Friedlander, M., Kirk, J., Gaff, C., Haan, E., Aittomaki, K., Tucker, K. (2000). Breast cancer screening uptake in women at increased risk of developing hereditary breast cancer. Breast Cancer Research and Treatment, 59(2), 101-111.
  • Kirk, J., Kefford, R. (2000). Cancer in the family: risks and management. Medical Journal of Australia, 172(11), 529-530.
  • Meiser, B., Butow, P., Friedlander, M., Schnieden, V., Gattas, M., Kirk, J., Suthers, G., Haan, E., Tucker, K. (2000). Intention to undergo prophylactic bilateral mastectomy in women at increased risk of developing hereditary breast cancer. Journal of Clinical Oncology, 18(11), 2250-2257.
  • Osborne, R., Hopper, J., Kirk, J., Chenevix-Trench, G., Thorne, H., Sambrook, J. (2000). kConFab: a research resource of Australasian breast cancer families. Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer. Medical Journal of Australia, 172(9), 463-464.

Magazine / Newspaper Articles

  • Jenkins, M., Macrae, F., Young, J., Barker, M., Leggett, B., Goldblatt, J., Kirk, J., Tucker, K., Suthers, G., Young, G., et al (2006). The Colorectal Cancer Family Registry: An international resource for studying the genetic and molecular epidemiology of colorectal cancer. Gastrointestinal Cancer Update Vol. 46.
  • Kirk, J. (2001). Explaining the familial aspects of breast cancer. The Beacon (Breast Cancer Network Australia).

2016

  • Kirk, J., Li, J., Meeks, H., Feng, B., Healey, S., Thorne, H., Makunin, I., Ellis, J., Campbell, I., Southey, M., et al (2016). Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families. Journal of Medical Genetics, 53(1), 34-42. [More Information]

2015

  • Douma, K., Meiser, B., Kirk, J., Mitchell, G., Saunders, C., Rahman, B., Sousa, M., Barlow-Stewart, K., Gleeson, M., Tucker, K. (2015). Health professionals' evaluation of delivering treatment-focused genetic testing to women newly diagnosed with breast cancer. Familial Cancer, 14(2), 265-272. [More Information]
  • Wu, K., Kirk, J. (2015). Hereditary colorectal cancer what you need to know what you need to know. Medicine Today, 16(2), 20-29.
  • Kuchenbaecker, K., Ramus, S., Tyrer, J., Lee, A., Shen, H., Beesley, J., Lawrenson, K., McGuffog, L., Kirk, J., et al (2015). Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nature Genetics, 47(2), 164-171. [More Information]

2014

  • Dunlop, K., Kirk, J., Tucker, K. (2014). In the wake of Angelina - Managing a family history of breast cancer. Australian Family Physician, 43(1-2), 76-78.
  • McBride, K., Ballinger, M., Killick, E., Kirk, J., Tattersall, M., Eeles, R., Thomas, D., Mitchell, G. (2014). Li-Fraumeni syndrome: cancer risk assessment and clinical management. Nature Reviews Clinical Oncology, 11(5), 260-271. [More Information]
  • Wickremeratne, T., Lee, C., Kirk, J., Charlton, A., Thomas, G., Gaskin, K. (2014). Prophylactic gastrectomy in a 16-year-old. European Journal of Gastroenterology and Hepatology, 26(3), 353-356. [More Information]
  • Buchanan, D., Tan, Y., Walsh, M., Clendenning, M., Metcalf, A., Ferguson, K., Arnold, S., Thompson, B., Lose, F., Parsons, M., Kirk, J., et al (2014). Reply to J. Moline et al. Journal of Clinical Oncology, 32(21), 2278-2279. [More Information]
  • Bancroft, E., Page, E., Castro, E., Lilja, H., Vickers, A., Sjoberg, D., Assel, M., Foster, C., Mitchell, G., Kirk, J., et al (2014). Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study. European Urology, 66(3), 489-499. [More Information]
  • Buchanan, D., Tan, Y., Walsh, M., Clendenning, M., Metcalf, A., Ferguson, K., Arnold, S., Thompson, B., Lose, F., Parsons, M., Kirk, J., et al (2014). Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for Population-Level Germline Mismatch Repair Gene Mutation Testing. Journal of Clinical Oncology, 32(2), 90-100. [More Information]

2013

  • Garcia-Closas, M., Couch, F., Lindstrom, S., Michailidou, K., Schmidt, M., Brook, M., Orr, N., Rhie, S., Riboli, E., Feigelson, H., Carpenter, J., Balleine, R., et al (2013). Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nature Genetics, 45(4), 392-398. [More Information]
  • Wakefield, C., Thorne, H., Kirk, J., Niedermayr, E., Doolan, E., Tucker, K. (2013). Improving mutation notification when new genetic information is identified in research: a trial of two strategies in familial breast cancer. Genetics in Medicine, 15(3), 187-194. [More Information]
  • Burcher, S., Meiser, B., Mitchell, G., Saunders, C., Rahman, B., Tucker, K., Barlow-Stewart, K., Watts, K., Gleeson, M., Kirk, J. (2013). Oncology health professionals attitudes toward treatment-focused genetic testing for women newly diagnosed with breast cancer. Personalized Medicine, 10(5), 431-440. [More Information]

2012

  • Antoniou, A., Kuchenbaecker, K., Soucy, P., Beesley, J., Chen, X., McGuffog, L., Lee, A., Barrowdale, D., Healey, S., Sinilnikova, O., Kirk, J., et al (2012). Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Research, 14(1), 1-18. [More Information]
  • Meiser, B., Gleeson, M., Watts, K., Peate, M., Zilliacus, E., Barlow-Stewart, K., Saunders, C., Mitchell, G., Kirk, J. (2012). Getting to the Point: What Women Newly Diagnosed with Breast Cancer Want to Know About Treatment-Focused Genetic Testing. Oncology Nursing Forum, 39(2), E101-E111. [More Information]
  • Watts, K., Meiser, B., Mitchell, G., Kirk, J., Saunders, C., Peate, M., Duffy, J., Kelly, P., Gleeson, M., Barlow-Stewart, K., et al (2012). How should we discuss genetic testing with women newly diagnosed with breast cancer? Design and implementation of a randomized controlled trial of two models of delivering education about treatment-focused genetic testing to younger women newly diagnosed with breast cancer. BMC Cancer, 12(1), 1-12. [More Information]
  • Saleh, M., Barlow-Stewart, K., Meiser, B., Tucker, K., Eisenbruch, M., Kirk, J. (2012). Knowledge, attitudes and beliefs of Arabic-Australians concerning cancer. Psycho-Oncology, 21(2), 195-202. [More Information]

2011

  • Saleh, M., Barlow-Stewart, K., Meiser, B., Kirk, J., Tucker, K. (2011). An Exploration of the Cultural Context of Kinship and Genetics Amongst Arabic-Australians: Implications for Practice. Journal of Genetic Counseling, 20(5), 465-475. [More Information]
  • Zilliacus, E., Meiser, B., Lobb, E., Kelly, P., Barlow-Stewart, K., Kirk, J., Spigelman, A., Warwick, L., Tucker, K. (2011). Are videoconferenced consultations as effective as face-to-face consultations for hereditary breast and ovarian cancer genetic counseling? Genetics in Medicine, 13(11), 933-941. [More Information]
  • Mitra, A., Bancroft, E., Barbachano, Y., Page, E., Foster, C., Jameson, C., Mitchell, G., Lindeman, G., Stapleton, A., Suthers, G., Kirk, J., et al (2011). Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study. BJU International, 107(1), 28-39. [More Information]

2010

  • Antill, Y., Mitchell, G., Johnson, S., Devereux, L., Milner, A., Di Iulio, J., Lindeman, G., Kirk, J., Phillips, K., Campbell, I. (2010). Gene Methylation in Breast Ductal Fluid from BRCA1 and BRCA2 Mutation Carriers. Cancer Epidemiology, Biomarkers and Prevention, 19(1), 265-274. [More Information]
  • Kirk, J. (2010). Genetic Testing for Cancer Susceptibility: How and When? In Monica Robotin, Ian Olver, Afaf Girgis (Eds.), When Cancer Crosses Disciplines: A Physicians Handbook, (pp. 931-939). London: Imperial College Press.
  • Whitaker, H., Kote-Jarai, Z., Ross-Adams, H., Warren, A., Burge, J., George, A., Bancroft, E., Jhavar, S., Leongamornlert, D., Tymrakiewicz, M., Kirk, J., et al (2010). The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. PloS One, 5(10), 1-8. [More Information]
  • Zilliacus, E., Meiser, B., Lobb, E., Kirk, J., Warwick, L., Tucker, K. (2010). Women's Experience of Telehealth Cancer Genetic Counseling. Journal of Genetic Counseling, 19(5), 463-472. [More Information]

2009

  • Shanley, S., Fung, C., Milliken, J., Leary, J., Barnetson, R., Schnitzler, M., Kirk, J. (2009). Breast cancer immunohistochemistry can be useful in triage of some HNPCC families. Familial Cancer, 8, 251-255. [More Information]

2008

  • Juan, A., Wakefield, C., Kasparian, N., Kirk, J., Tyler, J., Tucker, K. (2008). Development and Pilot Testing of a Decision Aid for Men Considering Genetic Testing for Breast and/or Ovarian Cancer-Related Mutations (BRCA1/2). Genetic Testing, 12, 523-532. [More Information]
  • Wakefield, C., Meiser, B., Homewood, J., Ward, R., O'Donnell, S., Kirk, J. (2008). Randomized trial of a decision aid for individuals considering genetic testing for hereditary nonpolyposis colorectal cancer risk. Cancer, 113, 956-965. [More Information]

2007

  • Wakefield, C., Meiser, B., Homewood, J., Peate, M., Taylor, A., Lobb, E., Kirk, J., Young, M., Williams, R., Dudding, T., et al (2007). A randomized controlled trial of a decision aid for women considering genetic testing for breast and ovarian cancer risk. Breast Cancer Research and Treatment, 107(2), 289-301. [More Information]
  • Wakefield, C., Kasparian, N., Meiser, B., Homewood, J., Kirk, J., Tucker, K. (2007). Attitudes Toward Genetic Testing for Cancer Risk after Genetic Counseling and Decision Support: A Qualitative Comparison between Hereditary Cancer Types. Genetic Testing, 11(4), 401-412. [More Information]
  • Wakefield, C., Meiser, B., Homewood, J., Peate, M., Kirk, J., Warner, B., Lobb, E., Gaff, C., Tucker, K. (2007). Development and pilot testing of two decision Aids for individuals considering genetic testing for cancer risk. Journal of Genetic Counseling, 16(3), 325-339. [More Information]
  • Featherstone, C., Colley, A., Tucker, K., Kirk, J., Barton, M. (2007). Estimating the referral rate for cancer genetic assessment from a systematic review of the evidence. British Journal of Cancer, 96(2), 391-398.
  • Field, M., Shanley, S., Kirk, J. (2007). Inherited cancer susceptibility syndromes in paediatric practice. Journal of Paediatrics and Child Health, 43(4), 219-229. [More Information]
  • Kirk, J., Suthers, G. (2007). Overview. Cancer Forum, 31(3), 135-138.
  • Kirk, J. (2007). The role of familial Cancer Services. Cancer Forum, 31(3), 136-138.

2006

  • Tiller, K., Meiser, B., Gaff, C., Kirk, J., Dudding, T., Phillips, K., Friedlander, M., Tucker, K. (2006). A randomized controlled trial of a decision aid for women at increased risk of ovarian cancer. Medical Decision Making, 26(4), 360-372. [More Information]
  • Kirk, J., Brennan, M., Houssami, N., Ung, O. (2006). An approach to the patient with a family history of breast cancer. Australian Family Physician, 35(1-2), 43-47. [More Information]
  • Mann, G., Thorne, H., Balleine, R., Butow, P., Clarke, C., Edkins, E., Evans, G., Fereday, S., Haan, E., Gattas, M., Kirk, J., Leary, J., Pupo, G., et al (2006). Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research, 8(1), 1-15. [More Information]
  • Lobb, E., Butow, P., Moore, A., Barratt, A., Tucker, K., Gaff, C., Kirk, J., Dudding, T., Butt, D. (2006). Development of a communication aid to facilitate risk communication in consultations with unaffected women from high risk breast cancer families: A pilot study. Journal of Genetic Counseling, 15(5), 393-405. [More Information]
  • Kang, H., Williams, R., Leary, J., Ringland, C., Kirk, J., Ward, R. (2006). Evaluation of models to predict BRCA germline mutations. British Journal of Cancer, 95(7), 914-920. [More Information]
  • Balleine, R., Murali, R., Bilous, M., Farshid, G., Waring, P., Provan, P., Byth Wilson, K., Thorne, H., KConFab, C., Kirk, J. (2006). Histopathological features of breast cancer in carriers of ATM gene variants. Histopathology, 49. [More Information]
  • Kirk, J. (2006). How can we best detect hereditary non-polyposis colorectal cancer? Medical Journal of Australia, 184(5), 206-207.
  • Antill, Y., Reynolds, J., Young, M., Kirk, J., Tucker, K., Bogtstra, T., Wong, S., Dudding, T., Di Iulio, J., Phillips, K. (2006). Risk-reducing surgery in women with familial susceptibility for breast and/or ovarian cancer. European Journal of Cancer, 42(5), 621-628. [More Information]
  • Antill, Y., Reynolds, J., Young, M., Kirk, J., Tucker, K., Bogtstra, T., Wong, S., Dudding, T., Di Iulio, J., Phillips, K. (2006). Screening behavior in women at increased familial risk for breast cancer. Familial Cancer, 5(4), 359-368. [More Information]
  • Jenkins, M., Macrae, F., Young, J., Barker, M., Leggett, B., Goldblatt, J., Kirk, J., Tucker, K., Suthers, G., Young, G., et al (2006). The Colorectal Cancer Family Registry: An international resource for studying the genetic and molecular epidemiology of colorectal cancer. Gastrointestinal Cancer Update Vol. 46.
  • Kirk, J. (2006). Who needs Cancer screening. ANZ Journal of Surgery, 76(Supp1), A78.

2005

  • Brennan, M., French, J., Houssami, N., Kirk, J., Boyages, J. (2005). Breast cancer in young women. Australian Family Physician, 34(10), 851-855. [More Information]
  • Woodward, A., Davis, T., Silva, A., KConFab, C., Kirk, J., Leary, J. (2005). Large genomic rearrangements of both BRCA2 and BRCA1 are a feature of the inherited breast/ovarian cancer phenotype in selected families. Journal of Medical Genetics, 42(5), e31-e34. [More Information]
  • Hitchins, M., Williams, R., Cheong, K., Halani, N., Lin, V., Packham, D., Ku, S., Buckle, A., Hawkins, N., Kirk, J., et al (2005). MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology, 129. [More Information]
  • Kairupan, C., Meldrum, C., Crooks, R., Milward, E., Spigelman, A., Burgess, B., Groombridge, C., Kirk, J., Tucker, K., Ward, R., et al (2005). Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations. International Journal of Cancer, 116(1), 73-77. [More Information]
  • Mitchell, G., Antill, Y., Murray, W., Kirk, J., Salisbury, E., Lindeman, G., Di Iulio, J., Milner, A., Devereaux, L., Phillips, K. (2005). Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation. Breast Cancer Research, 7(6), R1122-R1131. [More Information]
  • Weir, L., Spigelman, A., Scott, R., Kirk, J., Zeckendorf, S., Sitas, F. (2005). The NSW & ACT Hereditary Cancer Registers. Australian Family Physician, 34(1-2), 53-58. [More Information]

2004

  • Lindeman, G., Hiew, M., Visvader, J., Leary, J., Field, M., Gaff, C., McKinlay Garnder, R., Trainor, K., Cheetham, G., Suthers, G., Kirk, J. (2004). Frequency Of The Atm Ivs10-6T-->G Variant In Australian Multiple-Case Breast Cancer Families. Breast Cancer Research, 6(4), R401-7.
  • Mote, P., Leary, J., Avery, K., Sandelin, K., Chenevix-Trench, G., kConFab Investigators., Kirk, J., Clarke, C. (2004). Germ-Line Mutations In Brca1 Or Brca2 In The Normal Breast Are Associated With Altered Expression Of Estrogen-Responsive Proteins And The Predominance Of Progesterone Receptor A. Genes Chromosomes and Cancer, 39(3), 236-248. [More Information]
  • Kirk, J. (2004). Letter: Gene silencing. New England Journal of Medicine, 350(9), 947-948.
  • Kirk, J. (2004). Letter: Genetic testing: a round table conversation. Internal Medicine Journal, 34(7), 445.
  • Kirk, J. (2004). The family history of cancer - a common concern in palliative care. Progress in Palliative Care, 12(2), 59-66.
  • Keogh, L., Southey, M., Maskiell, J., Young, M., Gaff, C., Kirk, J., Tucker, K., Rosenthal, D., McCredie, M., Giles, G., et al (2004). Uptake of offer to receive genetic information about BRCA1 and BRCA2 mutations in an Australian population-based study. Cancer Epidemiology, Biomarkers and Prevention, 13(12), 2258-2263.

2003

  • Tiller, K., Meiser, B., Reeson, E., Tucker, M., Andrews, L., Gaff, C., Kirk, J., Phillips, K., Friedlander, M. (2003). A decision aid for women at increased risk for ovarian cancer. International Journal Of Gynecological Cancer, 13(1), 15-22.
  • Fisher, T., Kirk, J., Hopper, J., Godding, R., Burgemeister, F. (2003). A simple tool for identifying unaffected women at a moderately increased or potentially high risk of breast cancer based on their family history. The Breast, 12(2), 120-127.
  • Kirk, J. (2003). How to treat familial cancer. Australian Doctor, , 25-32.
  • Shannon, C., Kirk, J., Barnetson, R., Evans, J., Schnitzler, M., Quinn, M., Hacker, N., Crandon, A., Harnett, P. (2003). Incidence of microsatellite instability in synchronous tumors of the ovary and endometrium. Clinical Cancer Research, 9(4), 1387-1392.
  • Hallett, K., Cameron, A., Widmer, R., King, P., Kilpatrick, N., Wilson, M., Lucas, J., Wong, P., Mekertichian, K., Isaacs, D., Kirk, J., et al (2003). Medically compromised children. In Cameron, Widmer (Eds.), Handbook of Pediatric Dentistry, Second Editions, (pp. 234-286). Australia: Mosby.
  • Lobb, E., Butow, P., Meiser, B., Barratt, A., Gaff, C., Young, M., Kirk, J., Gattans, M., Gleeson, M., Tucker, K. (2003). Women's preferences and consultants' communication of risk in consultations about familial breast cancer: impact on patient outcomes. Journal of Medical Genetics, 40(5 - e56), 1-8.

2002

  • Chenevix-Trench, G., Spurdle, A., Gatei, M., Kelly, H., Marsh, A., Chen, X., Donn, K., Cummings, M., Nyholt, D., Jenkins, M., Pupo, G., Kirk, J., Tucker, P., Mann, G., et al (2002). Dominant Negative ATM Mutations in Breast Cancer Families. Journal of the National Cancer Institute, 94(3), 205-215.
  • Lobb, E., Butow, P., Meiser, B., Barratt, A., Gaff, C., Young, M., Kirk, J., Suthers, G., Tucker, K. (2002). Tailoring communication in consultations with women from high risk breast cancer families. British Journal of Cancer, 87(5), 502-508.
  • Lobb, E., Butow, P., Meiser, B., Barratt, A., Kirk, J., Gattas, M., Haan, E., Tucker, K. (2002). The use of audiotapes in consultations with women from high risk breast cancer families: a randomised trial. Journal of Medical Genetics, 39(9), 697-703.

2001

  • Kirk, J. (2001). Explaining the familial aspects of breast cancer. The Beacon (Breast Cancer Network Australia).
  • Scott, R., Meldrum, C., Crooks, R., Spigelman, A., Kirk, J., Tucker, K., Koorey, D., Hunter, F. (2001). Familial adenomatous polyposis: more evidence for disease diversity and genetic heterogeneity. Gut (English Edition): an international journal of gastroenterology and hepatology, 48(4), 508-514.
  • Scott, R., McPhillips, M., Meldrum, C., FitzGerald, P., Adams, K., Spigelman, A., du Sart, D., Tucker, K., Kirk, J. (2001). Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds. American Journal of Human Genetics, 68(1), 118-127.
  • Randall, J., Butow, P., Kirk, J., Tucker, K. (2001). Psychological impact of genetic counselling and testing in women previously diagnosed with breast cancer. Internal Medicine Journal, 31(7), 397-405.

2000

  • Meiser, B., Butow, P., Barratt, A., Friedlander, M., Kirk, J., Gaff, C., Haan, E., Aittomaki, K., Tucker, K. (2000). Breast cancer screening uptake in women at increased risk of developing hereditary breast cancer. Breast Cancer Research and Treatment, 59(2), 101-111.
  • Kirk, J., Kefford, R. (2000). Cancer in the family: risks and management. Medical Journal of Australia, 172(11), 529-530.
  • Meiser, B., Butow, P., Friedlander, M., Schnieden, V., Gattas, M., Kirk, J., Suthers, G., Haan, E., Tucker, K. (2000). Intention to undergo prophylactic bilateral mastectomy in women at increased risk of developing hereditary breast cancer. Journal of Clinical Oncology, 18(11), 2250-2257.
  • Osborne, R., Hopper, J., Kirk, J., Chenevix-Trench, G., Thorne, H., Sambrook, J. (2000). kConFab: a research resource of Australasian breast cancer families. Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer. Medical Journal of Australia, 172(9), 463-464.

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