Dr Julian Barden

Honorary Senior Research Fellow
Anatomy & Histology, School of Medical Sciences

Map

Research interests

cancer diagnostics and therapeutics, immunotherapeutics

Selected grants

2002

  • Location and structure of ATP binding sites on P2X receptors: factors controlling channel gating; Barden J; DVC Research/Bridging Support Grant.
  • Tumour B-cells from lymphomas are resistant to ATP-mediated apoptosis due to non-functional P2X7 receptors; Wiley J, Barden J, Sluyter R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Killing of mycobacterium tuberculosis in macrophages via the P2X7 receptor; Wiley J, Saunders B, Barden J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Location and structure of ATP binding sites on P2X receptors: factors controlling channel gating; Barden J; University of Sydney/Medicine Bridging.

2001

  • The location and structure of the ATP binding sites on P2X calcium channels and how they function; Barden J; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • Research agreement between Biosceptre and The University of Sydney; Gidley-Baird A, Sigalla A, Barden J; Biosceptre International Limited/Research Grants.
  • Grant-in-Aid; Barden J; National Health and Medical Research Council (NHMRC)/Project Grants.

1996

  • Structure-function analysis of human parathyroid hormone-related protein active domains; Barden J; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Slater, M., Lauer, C., Gidley-Baird, A., Barden, J. (2005). Markers for the development of early prostate cancer. In Hayat M (Eds.), Handbook of Immunohistochemistry & in situ Hybridization of Human Carcinomas, Vol. 2 (Molecular Pathology, Colorectal Carcinoma and Prostate Carcinoma), (pp. 335-346). New York: Elsevier.

Journals

  • Cham, J., Owens, N., Barden, J., Lawrence, A., Badoer, E. (2006). P2X purinoceptor subtypes on paraventricular nucleus neurones projecting to the rostral ventrolateral medulla in the rat. Experimental Physiology, 91(2), 403-411. [More Information]
  • Slater, M., Barden, J. (2005). Differentiating keratoacanthoma from squamous cell carcinoma by the use of apoptotic and cell adhesion markers. Histopathology, 47(2), 170-178. [More Information]
  • Slater, M., Danieletto, S., Barden, J. (2005). Expression of the apoptotic calcium channel P2X7 in the glandular epithelium. Journal of Molecular Histology, 36(3), 159-165. [More Information]
  • Tanneur, V., Duranton, C., Brand, V., Sandu, C., Akkaya, C., Kasinathan, R., Gachet, C., Sluyter, R., Barden, J., Wiley, J., et al (2005). Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes. The F A S E B Journal, online, 1-27. [More Information]
  • Gu, B., Sluyter, R., Skarratt, K., Shemon, A., Dao-Ung, L., Fuller, S., Barden, J., Clarke, A., Petrou, S., Wiley, J. (2004). An Arg307 To Gln Polymorphism Within The Atp-Binding Site Causes Loss Of Function Of The Human P2X7 Receptor. Journal of Biological Chemistry, 279(30), 31287-31295.
  • Slater, M., Danieletto, S., Pooley, M., Teh, L., Gidley-Baird, A., Barden, J. (2004). Differentiation Between Cancerous And Normal Hyperplastic Lobules In Breast Lesions. Breast Cancer Research and Treatment, 83(1), 1-10.
  • Slater, M., Danieletto, S., Gidley-Baird, A., Teh, L., Barden, J. (2004). Early Prostate Cancer Detected Using Expression Of Non-Functional Cytolytic P2X7 Receptors. Histopathology, 44(3), 206-215.
  • Sluyter, R., Shemon, A., Barden, J., Wiley, J. (2004). Extracellular ATP Increases Cation Fluxes In Human Erythrocytes By Activation Of The P2X7 Receptor. Journal of Biological Chemistry, 279(43), 44749-44755.
  • Wiley, J., Dao-Ung, L., Li, C., Shemon, A., Gu, B., Smart, M., Fuller, S., Barden, J., Petrou, S., Sluyter, R. (2003). An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. Journal of Biological Chemistry, 278(19), 17108-17113.
  • Ju, Y., Huang, W., Jiang, L., Barden, J., Allen, D. (2003). ATP modulates intracellular Ca2+ and firing rate through a P2Y 1 purinoceptor in cane toad pacemaker cells. The Journal of Physiology, 552(3), 777-787.
  • Lee, E., Pollock, C., Drumm, K., Barden, J., Poronnik, P. (2003). Effects of pathophysiological concentrations of albumin on NHE3 activity and cell proliferation in primary cultures of human proximal tubule cells. American Journal of Physiology: Renal Physiology (Print), 258(4), F748-F757.
  • Slater, M., Scolyer, R., Gidley-Baird, A., Thompson, J., Barden, J. (2003). Increased expression of apoptotic markers in melanoma. Melanoma Research: a journal for basic, translational and clinical research in melanoma, 13(2), 137-145.
  • Yao, S., Gourine, A., Spyer, K., Barden, J., Lawrence, A. (2003). Localisation of P2X2 receptor subunit immunoreactivity on nitric oxide synthase expressing neurones in the brain stem and hypothalamus of the rat: a fluorescence immunohistochemical study. Neuroscience, 121(2), 411-419.
  • Ray, F., Moore, K., Hansen, M., Barden, J. (2003). Loss of purinergic P2X receptor innervation in human detrusor and subepithelium from adults with sensory urgency. Cell and Tissue Research, 314(3), 351-359. [More Information]
  • Slater, M., Lauer, C., Gidley-Baird, A., Barden, J. (2003). Markers for the development of early prostate cancer. Journal of Pathology, 199(3), 368-377. [More Information]
  • Barden, J., Sluyter, R., Gu, B., Wiley, J. (2003). Specific detection of non-functional human P2X7 receptors in HEK293 cells and B-lymphocytes. FEBS Letters, 538(1-3), 159-162.
  • Cummins, M., O'Mullane, L., Barden, J., Cook, D., Poronnik, P. (2002). Antisense co-suppression of Galphaq & Galpha11 demonstrates that both isoforms mediate M3-receptor-activated Ca2+ signalling in intact epithelial cells. Pfluegers Archiv: European journal of physiology, 444(5), 644-653. [More Information]
  • Nelson, A., Barden, J., Martin, E., Tasevski, V., Hogan, G., Mason, R., Robinson, B. (2002). Bioactivity of PTH/PTHrP analogs lacking the 1-14 N-terminal domain. Molecular And Cellular Endocrinology, 189(1-2), 37-49.
  • Fong, A., Krstew, E., Barden, J., Lawrence, A. (2002). Immunoreactive localisation of P2Y1 receptors within the rat and human nodose ganglia & rat brainstem: comparison with [a33P]deoxyadenosine 5'-triphosphate autoradiography. Neuroscience, 113(4), 809-823.
  • Worthington, R., Smart, M., Gu, B., Williams, D., Petrou, S., Wiley, J., Barden, J. (2002). Point mutations confer loss of ATP-induced human P2X7 receptor function. FEBS Letters, 512(1-3), 43-46.
  • Ray, F., Huang, W., Slater, M., Barden, J. (2002). Purinergic receptor distribution in endothelial cells in blood vessels: a basis for selection of coronary artery grafts. Atherosclerosis, 162(1), 55-61.
  • Slater, M., Murphy, C., Barden, J. (2002). Purinergic receptor expression in the apical plasma membrane of rat uterine eithelial cells during implantation. Cell Calcium, 31(5), 201-207.
  • Slater, M., Murphy, C., Barden, J. (2002). Tenascin, E-cadherin. Journal of Molecular Histology, 34(1-2), 13-19.
  • Gu, B., Zhang, W., Worthington, R., Sluyter, R., Barden, J., Wiley, J., Dao, L., Petrou, S. (2001). A Glu-496 to ala polymorphism leads to loss of function of the human P2Z7 receptor. Journal of Biological Chemistry, 276, 11135-11142.
  • Sluyter, R., Barden, J., Wiley, J. (2001). Detection of P2x purinergic receptors on human B lymphocytes. Cell and Tissue Research, 304 (2), 231-236.
  • Slater, M., Murphy, C., Barden, J., Delprado, W. (2001). Detection of preneoplasia in histologically normal prostate biopsies. Prostate Cancer and Prostatic Diseases, 4 (2), 92-96.
  • Barden, J., Kukley,, M., Steinhauser, C., Jabs, R. (2001). Distribution of P2X receptors on astrocytes in juvenile rat hippocampus. Glia, 36 (1), 11-21.
  • Wiley, J., Gu, B., Zhang, W., Worthington, R., Dao, L., Shemon, A., Sluyter, R., Liang, S., Barden, J. (2001). Genetic polymorphisms of the human P2X7 receptor and rleationship to function. Drug Development Research, 53 (2-3), 72-76.
  • Bennett, M., Barden, J. (2001). Ionotropic (P2X) receptor dynamics at single autonomic varicosities. NeuroReport, 12 No 16.
  • Ray, F., Barden, J., Moore, K. (2001). Loss of Purinergic P2X3 & P2X5 receptor innervation in human detrusor from adults with urge incontinence. The Journal of Neuroscience, 21 (18), 1-6.
  • Barden, J., Yao,, S., Lawrence, A. (2001). On the immunohistochemical distribution of ionotropic P2X receptors in the nucleus tractus solitarius of the rat. Neuroscience, 108 (4), 673-685.

2006

  • Cham, J., Owens, N., Barden, J., Lawrence, A., Badoer, E. (2006). P2X purinoceptor subtypes on paraventricular nucleus neurones projecting to the rostral ventrolateral medulla in the rat. Experimental Physiology, 91(2), 403-411. [More Information]

2005

  • Slater, M., Barden, J. (2005). Differentiating keratoacanthoma from squamous cell carcinoma by the use of apoptotic and cell adhesion markers. Histopathology, 47(2), 170-178. [More Information]
  • Slater, M., Danieletto, S., Barden, J. (2005). Expression of the apoptotic calcium channel P2X7 in the glandular epithelium. Journal of Molecular Histology, 36(3), 159-165. [More Information]
  • Slater, M., Lauer, C., Gidley-Baird, A., Barden, J. (2005). Markers for the development of early prostate cancer. In Hayat M (Eds.), Handbook of Immunohistochemistry & in situ Hybridization of Human Carcinomas, Vol. 2 (Molecular Pathology, Colorectal Carcinoma and Prostate Carcinoma), (pp. 335-346). New York: Elsevier.
  • Tanneur, V., Duranton, C., Brand, V., Sandu, C., Akkaya, C., Kasinathan, R., Gachet, C., Sluyter, R., Barden, J., Wiley, J., et al (2005). Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes. The F A S E B Journal, online, 1-27. [More Information]

2004

  • Gu, B., Sluyter, R., Skarratt, K., Shemon, A., Dao-Ung, L., Fuller, S., Barden, J., Clarke, A., Petrou, S., Wiley, J. (2004). An Arg307 To Gln Polymorphism Within The Atp-Binding Site Causes Loss Of Function Of The Human P2X7 Receptor. Journal of Biological Chemistry, 279(30), 31287-31295.
  • Slater, M., Danieletto, S., Pooley, M., Teh, L., Gidley-Baird, A., Barden, J. (2004). Differentiation Between Cancerous And Normal Hyperplastic Lobules In Breast Lesions. Breast Cancer Research and Treatment, 83(1), 1-10.
  • Slater, M., Danieletto, S., Gidley-Baird, A., Teh, L., Barden, J. (2004). Early Prostate Cancer Detected Using Expression Of Non-Functional Cytolytic P2X7 Receptors. Histopathology, 44(3), 206-215.
  • Sluyter, R., Shemon, A., Barden, J., Wiley, J. (2004). Extracellular ATP Increases Cation Fluxes In Human Erythrocytes By Activation Of The P2X7 Receptor. Journal of Biological Chemistry, 279(43), 44749-44755.

2003

  • Wiley, J., Dao-Ung, L., Li, C., Shemon, A., Gu, B., Smart, M., Fuller, S., Barden, J., Petrou, S., Sluyter, R. (2003). An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. Journal of Biological Chemistry, 278(19), 17108-17113.
  • Ju, Y., Huang, W., Jiang, L., Barden, J., Allen, D. (2003). ATP modulates intracellular Ca2+ and firing rate through a P2Y 1 purinoceptor in cane toad pacemaker cells. The Journal of Physiology, 552(3), 777-787.
  • Lee, E., Pollock, C., Drumm, K., Barden, J., Poronnik, P. (2003). Effects of pathophysiological concentrations of albumin on NHE3 activity and cell proliferation in primary cultures of human proximal tubule cells. American Journal of Physiology: Renal Physiology (Print), 258(4), F748-F757.
  • Slater, M., Scolyer, R., Gidley-Baird, A., Thompson, J., Barden, J. (2003). Increased expression of apoptotic markers in melanoma. Melanoma Research: a journal for basic, translational and clinical research in melanoma, 13(2), 137-145.
  • Yao, S., Gourine, A., Spyer, K., Barden, J., Lawrence, A. (2003). Localisation of P2X2 receptor subunit immunoreactivity on nitric oxide synthase expressing neurones in the brain stem and hypothalamus of the rat: a fluorescence immunohistochemical study. Neuroscience, 121(2), 411-419.
  • Ray, F., Moore, K., Hansen, M., Barden, J. (2003). Loss of purinergic P2X receptor innervation in human detrusor and subepithelium from adults with sensory urgency. Cell and Tissue Research, 314(3), 351-359. [More Information]
  • Slater, M., Lauer, C., Gidley-Baird, A., Barden, J. (2003). Markers for the development of early prostate cancer. Journal of Pathology, 199(3), 368-377. [More Information]
  • Barden, J., Sluyter, R., Gu, B., Wiley, J. (2003). Specific detection of non-functional human P2X7 receptors in HEK293 cells and B-lymphocytes. FEBS Letters, 538(1-3), 159-162.

2002

  • Cummins, M., O'Mullane, L., Barden, J., Cook, D., Poronnik, P. (2002). Antisense co-suppression of Galphaq & Galpha11 demonstrates that both isoforms mediate M3-receptor-activated Ca2+ signalling in intact epithelial cells. Pfluegers Archiv: European journal of physiology, 444(5), 644-653. [More Information]
  • Nelson, A., Barden, J., Martin, E., Tasevski, V., Hogan, G., Mason, R., Robinson, B. (2002). Bioactivity of PTH/PTHrP analogs lacking the 1-14 N-terminal domain. Molecular And Cellular Endocrinology, 189(1-2), 37-49.
  • Fong, A., Krstew, E., Barden, J., Lawrence, A. (2002). Immunoreactive localisation of P2Y1 receptors within the rat and human nodose ganglia & rat brainstem: comparison with [a33P]deoxyadenosine 5'-triphosphate autoradiography. Neuroscience, 113(4), 809-823.
  • Worthington, R., Smart, M., Gu, B., Williams, D., Petrou, S., Wiley, J., Barden, J. (2002). Point mutations confer loss of ATP-induced human P2X7 receptor function. FEBS Letters, 512(1-3), 43-46.
  • Ray, F., Huang, W., Slater, M., Barden, J. (2002). Purinergic receptor distribution in endothelial cells in blood vessels: a basis for selection of coronary artery grafts. Atherosclerosis, 162(1), 55-61.
  • Slater, M., Murphy, C., Barden, J. (2002). Purinergic receptor expression in the apical plasma membrane of rat uterine eithelial cells during implantation. Cell Calcium, 31(5), 201-207.
  • Slater, M., Murphy, C., Barden, J. (2002). Tenascin, E-cadherin. Journal of Molecular Histology, 34(1-2), 13-19.

2001

  • Gu, B., Zhang, W., Worthington, R., Sluyter, R., Barden, J., Wiley, J., Dao, L., Petrou, S. (2001). A Glu-496 to ala polymorphism leads to loss of function of the human P2Z7 receptor. Journal of Biological Chemistry, 276, 11135-11142.
  • Sluyter, R., Barden, J., Wiley, J. (2001). Detection of P2x purinergic receptors on human B lymphocytes. Cell and Tissue Research, 304 (2), 231-236.
  • Slater, M., Murphy, C., Barden, J., Delprado, W. (2001). Detection of preneoplasia in histologically normal prostate biopsies. Prostate Cancer and Prostatic Diseases, 4 (2), 92-96.
  • Barden, J., Kukley,, M., Steinhauser, C., Jabs, R. (2001). Distribution of P2X receptors on astrocytes in juvenile rat hippocampus. Glia, 36 (1), 11-21.
  • Wiley, J., Gu, B., Zhang, W., Worthington, R., Dao, L., Shemon, A., Sluyter, R., Liang, S., Barden, J. (2001). Genetic polymorphisms of the human P2X7 receptor and rleationship to function. Drug Development Research, 53 (2-3), 72-76.
  • Bennett, M., Barden, J. (2001). Ionotropic (P2X) receptor dynamics at single autonomic varicosities. NeuroReport, 12 No 16.
  • Ray, F., Barden, J., Moore, K. (2001). Loss of Purinergic P2X3 & P2X5 receptor innervation in human detrusor from adults with urge incontinence. The Journal of Neuroscience, 21 (18), 1-6.
  • Barden, J., Yao,, S., Lawrence, A. (2001). On the immunohistochemical distribution of ionotropic P2X receptors in the nucleus tractus solitarius of the rat. Neuroscience, 108 (4), 673-685.

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