Dr Justine Gatt

Senior Research Fellow Level C
Psychiatry, Westmead Clinical School
Brain Dynamics Centre

Telephone +61 2 9845 8164
Fax +61 2 9845 8190

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Biographical details

Dr Justine Gatt is a NHMRC CDF Senior Research Fellow at the Brain Dynamics Centre, Sydney Medical School. Justine's research outcomes to date include over 30 peer-reviewed papers and conference abstracts, with many in leading journals such as Molecular Psychiatry and Biological Psychiatry. Her research outcomes have been recognised by several awards including the NHMRC CDF Fellowship (2014-2017), the ARC-Linkage Postdoctoral Industry fellowship (2008-2011), the WMI Science Prize (2009, 2010), the Australian Twins Registry Travel Award (2008) and the Human Brain Mapping Young Investigator award (2006).

Research interests

Dr Justine Gatt's research aims to understand and identify the predictors of risk and resilience for mental health in twins. Her approach is mult-disciplinary and integrative across various markers including genetic variants, environment, brain function and behavior. Ultimately, Justine hopes to identify effective intervention strategies that optimize wellbeing and prevent the onset of mental illness in the general population.

Current research students

Project title Research student
Early life stress effects on the psychophysiology of emotion processing in community adults and adults with Posttraumatic Stress Disorder Denise CHU

Keywords

Trauma; Genetics; Wellbeing; Resilience; Neurosciences

Clinical Specialty

Psychiatry

Selected grants

2014

  • Industry CDF Level 1 - Resilience - What is it and how do we promote it; Gatt J; National Health and Medical Research Council (NHMRC)/Career Development Fellowships.

2012

  • The neurogenetics of mental well-being - focusing on resilience; Gatt J; DVC Research/Bridging Support Fellowship.

2009

  • Gene-brain pathways in emotional brain stability and instability; Revai A, Clark C, Segal D, Schofield P, Goodman S, Kemp A, Williams L, Schofield P, Clark C, Harris A, Gatt J; Australian Research Council (ARC)/Linkage Projects (LP).

Selected publications

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Books

  • Gatt, J. (2008). The Role of Personality in Disease: Detection and Prevention. Germany: VDM Verlag Dr Muller.

Journals

  • Arns, M., Bruder, G., Hegerl, U., Spooner, C., Palmer, D., Etkin, A., Fallahpour, K., Gatt, J., Hirshberg, L., Gordon, E. (2016). EEG alpha asymmetry as a gender-specific predictor of outcome to acute treatment with different antidepressant medications in the randomized iSPOT-D study. Clinical Neurophysiology, 127(1), 509-519. [More Information]
  • Chu, D., Bryant, R., Gatt, J., Harris, A. (2016). Failure to differentiate between threat-related and positive emotion cues in healthy adults with childhood interpersonal or adult trauma. Journal of Psychiatric Research, 78, 31-41. [More Information]
  • Routledge, K., Oakley, K., Williams, L., Harris, A., Schofield, P., Clark, C., Gatt, J. (2016). Shared versus distinct genetic contributions of mental wellbeing with depression and anxiety symptoms in healthy twins. Psychiatry Research, 244, 65-70. [More Information]
  • Day, C., Gatt, J., Etkin, A., DeBattista, C., Schatzberg, A., Williams, L. (2015). Cognitive and emotional biomarkers of melancholic depression: An iSPOT-D report. Journal of Affective Disorders, 176, 141-150. [More Information]
  • Burton, K., Williams, L., Richard Clark, C., Harris, A., Schofield, P., Gatt, J. (2015). Sex differences in the shared genetics of dimensions of self-reported depression and anxiety. Journal of Affective Disorders, 188, 35-42. [More Information]
  • Gatt, J., Burton, K., Williams, L., Schofield, P. (2015). Specific and common genes implicated across major mental disorders: A review of meta-analysis studies. Journal of Psychiatric Research, 60(C), 1-13. [More Information]
  • Korgaonkar, M., Ram, K., Williams, L., Gatt, J., Grieve, S. (2014). Establishing the Resting State Default Mode Network Derived From Functional Magnetic Resonance Imaging Tasks as an Endophenotype: A Twins Study. Human Brain Mapping, 35(8), 3893-3902. [More Information]
  • Gatt, J., Oakley, K., Schofield, P., Bryant, R., Williams, L. (2014). The heritability of mental health and wellbeing defined using COMPAS-W, a new composite measure of wellbeing. Psychiatry Research, 219, 204-213. [More Information]
  • Myers, A., Williams, L., Gatt, J., McAuley-Clark, E., Dobson-Stone, C., Schofield, P., Nemeroff, C. (2014). Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress. Journal of Psychiatric Research, 59, 93-100. [More Information]
  • Korgaonkar, M., Antees, C., Williams, L., Gatt, J., Bryant, R., Cohen, R., Paul, R., O'Hara, R., Grieve, S. (2013). Early Exposure to Traumatic Stressors Impairs Emotional Brain Circuitry. PloS One, 8(9), 1-8. [More Information]
  • Chu, D., Williams, L., Harris, A., Bryant, R., Gatt, J. (2013). Early life trauma predicts self-reported levels of depressive and anxiety symptoms in nonclinical community adults: Relative contributions of early life stressor types and adult trauma exposure. Journal of Psychiatric Research, 47(1), 23-32. [More Information]
  • Williams, L., Cooper, N., Wisniewski, S., Gatt, J., Koslow, S., Kulkarni, J., DeVarney, S., Gordon, E., Rush, A. (2012). Sensitivity, specificity, and predictive power of the "Brief Risk-resilience Index for SCreening," a brief pan-diagnostic web screen for emotional health. Brain and Behavior, 2(5), 576-589. [More Information]
  • Gatt, J., Korgaonkar, M., Schofield, P., Harris, A., Clark, C., Oakley, K., Ram, K., Michaelson, H., Yap, S., Stanners, M., Williams, L., et al (2012). The TWIN-E Project in Emotional Wellbeing: Study Protocol and Preliminary Heritability Results Across Four MRI and DTI Measures. Twin Research and Human Genetics, 15(3), 419-441. [More Information]
  • Williams, L., Gatt, J., Grieve, S., Dobson-Stone, C., Paul, R., Gordon, E., Schofield, P. (2010). COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias. NeuroImage, 53(3), 918-925. [More Information]
  • Gatt, J., Nemeroff, C., Schofield, P., Paul, R., Clark, C., Gordon, E., Williams, L. (2010). Early Life Stress Combined with Serotonin 3A Receptor and Brain-Derived Neurotrophic Factor Valine 66 to Methionine Genotypes Impacts Emotional Brain and Arousal Correlates of Risk for Depression. Biological Psychiatry, 68(9), 818-824. [More Information]
  • Kemp, A., Quintana, D., Gray, M., Felmingham, K., Brown, K., Gatt, J. (2010). Impact of Depression and Antidepressant Treatment on Heart Rate Variability: A Review and Meta-Analysis. Biological Psychiatry, 67(11), 1067-1074. [More Information]
  • Gatt, J., Williams, L., Schofield, P., Dobson-Stone, C., Paul, R., Grieve, S., Clark, R., Gordon, E., Nemeroff, C. (2010). Impact of the HTR3A Gene With Early Life Trauma on Emotional Brain Networks and Depressed Mood. Depression and Anxiety, 27(8), 752-759. [More Information]
  • Wacker, J., Gatt, J. (2010). Resting posterior versus frontal delta/theta EEG activity is associated with extraversion and the COMT VAL(158)MET polymorphism. Neuroscience Letters, 478(2), 88-92. [More Information]
  • Williams, L., Gatt, J., Schofield, P., Olivieri, G., Peduto, A., Gordon, E. (2009). 'Negativity bias' in risk for depression and anxiety: Brain-body fear circuitry correlates, 5-HTT-LPR and early life stress. NeuroImage, 47(3), 804-814. [More Information]
  • Williams, L., Gatt, J., Kuan, S., Dobson-Stone, C., Paul, R., Palmer, D., Song, L., Costa, P., Schofield, P., Gordon, E. (2009). A Polymorphism of the MAOA Gene is Associated with Emotional Brain Markers and Personality Traits on an Antisocial Index. Neuropsychopharmacology, 34(7), 1797-1809. [More Information]
  • Joffe, R., Gatt, J., Kemp, A., Grieve, S., Dobson-Stone, C., Kuan, S., Schofield, P., Gordon, E., Williams, L. (2009). Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness. Human Brain Mapping, 30(4), 1246-1256. [More Information]
  • Schofield, P., Williams, L., Paul, R., Gatt, J., Brown, K., Luty, A., Cooper, N., Grieve, S., Dobson-Stone, C., Morris, C., Kuan, S., Gordon, E. (2009). Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: Evidence from cognition, the P300 and fronto-hippocampal systems. Biological Psychology, 80(2), 176-188. [More Information]
  • Gatt, J., Nemeroff, C., Dobson-Stone, C., Paul, R., Bryant, R., Schofield, P., Gordon, E., Kemp, A., Williams, L. (2009). Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Molecular Psychiatry, 14(7), 681-695. [More Information]
  • Gatt, J., Kuan, S., Dobson-Stone, C., Paul, R., Joffe, R., Kemp, A., Gordon, E., Schofield, P., Williams, L. (2008). Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity. Biological Psychology, 79(2), 275-284. [More Information]
  • Williams, L., Gatt, J., Hatch, A., Palmer, D., Nagy, M., Rennie, C., Cooper, N., Morris, C., Grieve, S., Dobson-Stone, C., Gordon, E., et al (2008). The integrate model of emotion, thinking and self regulation: an application to the "paradox of aging". Journal of Integrative Neuroscience, 7(3), 367-404. [More Information]
  • Gatt, J., Clark, C., Kemp, A., Liddell, B., Dobson-Stone, C., Kuan, S., Schofield, P., Williams, L. (2007). A genotype-endophenotype-phenotype path model of depressed mood: integrating cognitive and emotional markers. Journal of Integrative Neuroscience, 6(1), 75-104. [More Information]
  • Gordon, E., Liddell, B., Brown, K., Bryant, R., Clark, C., Das, P., Dobson-Stone, C., Falconer, E., Felmingham, K., Flynn, G., Gatt, J., Harris, A., Hermens, D., Hopkinson, P., Kemp, A., Kuan, S., Lazzaro, I., Rennie, C., Whitford, T., Williams, L., et al (2007). Integrating objective gene-brain-behavior markers of psychiatric disorders. Journal of Integrative Neuroscience, 6(1), 1-34. [More Information]
  • Dobson-Stone, C., Gatt, J., Kuan, S., Grieve, S., Gordon, E., Williams, L., Schofield, P. (2007). Investigation of MCPH1 G37995C and ASPM A44871G polymorphisms and brain size in a healthy cohort. NeuroImage, 37(2), 394-400. [More Information]
  • Alexander, D., Williams, L., Gatt, J., Dobson-Stone, C., Kuan, S., Todd, E., Schofield, P., Cooper, N., Gordon, E. (2007). The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades. Biological Psychology, 75(3), 229-238. [More Information]

Conferences

  • Paul, R., Schofield, P., Gordon, E., Kuan, S., Williams, L., Dobson-Stone, C., Gatt, J. (2007). Genotypes and neural binding in negative affect: The contribution of genetic polymorphisms to 40 hz gamma phase synchrony. 62nd Annual Convention and Scientific Program SOBP, United States: Elsevier Science.

2016

  • Arns, M., Bruder, G., Hegerl, U., Spooner, C., Palmer, D., Etkin, A., Fallahpour, K., Gatt, J., Hirshberg, L., Gordon, E. (2016). EEG alpha asymmetry as a gender-specific predictor of outcome to acute treatment with different antidepressant medications in the randomized iSPOT-D study. Clinical Neurophysiology, 127(1), 509-519. [More Information]
  • Chu, D., Bryant, R., Gatt, J., Harris, A. (2016). Failure to differentiate between threat-related and positive emotion cues in healthy adults with childhood interpersonal or adult trauma. Journal of Psychiatric Research, 78, 31-41. [More Information]
  • Routledge, K., Oakley, K., Williams, L., Harris, A., Schofield, P., Clark, C., Gatt, J. (2016). Shared versus distinct genetic contributions of mental wellbeing with depression and anxiety symptoms in healthy twins. Psychiatry Research, 244, 65-70. [More Information]

2015

  • Day, C., Gatt, J., Etkin, A., DeBattista, C., Schatzberg, A., Williams, L. (2015). Cognitive and emotional biomarkers of melancholic depression: An iSPOT-D report. Journal of Affective Disorders, 176, 141-150. [More Information]
  • Burton, K., Williams, L., Richard Clark, C., Harris, A., Schofield, P., Gatt, J. (2015). Sex differences in the shared genetics of dimensions of self-reported depression and anxiety. Journal of Affective Disorders, 188, 35-42. [More Information]
  • Gatt, J., Burton, K., Williams, L., Schofield, P. (2015). Specific and common genes implicated across major mental disorders: A review of meta-analysis studies. Journal of Psychiatric Research, 60(C), 1-13. [More Information]

2014

  • Korgaonkar, M., Ram, K., Williams, L., Gatt, J., Grieve, S. (2014). Establishing the Resting State Default Mode Network Derived From Functional Magnetic Resonance Imaging Tasks as an Endophenotype: A Twins Study. Human Brain Mapping, 35(8), 3893-3902. [More Information]
  • Gatt, J., Oakley, K., Schofield, P., Bryant, R., Williams, L. (2014). The heritability of mental health and wellbeing defined using COMPAS-W, a new composite measure of wellbeing. Psychiatry Research, 219, 204-213. [More Information]
  • Myers, A., Williams, L., Gatt, J., McAuley-Clark, E., Dobson-Stone, C., Schofield, P., Nemeroff, C. (2014). Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress. Journal of Psychiatric Research, 59, 93-100. [More Information]

2013

  • Korgaonkar, M., Antees, C., Williams, L., Gatt, J., Bryant, R., Cohen, R., Paul, R., O'Hara, R., Grieve, S. (2013). Early Exposure to Traumatic Stressors Impairs Emotional Brain Circuitry. PloS One, 8(9), 1-8. [More Information]
  • Chu, D., Williams, L., Harris, A., Bryant, R., Gatt, J. (2013). Early life trauma predicts self-reported levels of depressive and anxiety symptoms in nonclinical community adults: Relative contributions of early life stressor types and adult trauma exposure. Journal of Psychiatric Research, 47(1), 23-32. [More Information]

2012

  • Williams, L., Cooper, N., Wisniewski, S., Gatt, J., Koslow, S., Kulkarni, J., DeVarney, S., Gordon, E., Rush, A. (2012). Sensitivity, specificity, and predictive power of the "Brief Risk-resilience Index for SCreening," a brief pan-diagnostic web screen for emotional health. Brain and Behavior, 2(5), 576-589. [More Information]
  • Gatt, J., Korgaonkar, M., Schofield, P., Harris, A., Clark, C., Oakley, K., Ram, K., Michaelson, H., Yap, S., Stanners, M., Williams, L., et al (2012). The TWIN-E Project in Emotional Wellbeing: Study Protocol and Preliminary Heritability Results Across Four MRI and DTI Measures. Twin Research and Human Genetics, 15(3), 419-441. [More Information]

2010

  • Williams, L., Gatt, J., Grieve, S., Dobson-Stone, C., Paul, R., Gordon, E., Schofield, P. (2010). COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias. NeuroImage, 53(3), 918-925. [More Information]
  • Gatt, J., Nemeroff, C., Schofield, P., Paul, R., Clark, C., Gordon, E., Williams, L. (2010). Early Life Stress Combined with Serotonin 3A Receptor and Brain-Derived Neurotrophic Factor Valine 66 to Methionine Genotypes Impacts Emotional Brain and Arousal Correlates of Risk for Depression. Biological Psychiatry, 68(9), 818-824. [More Information]
  • Kemp, A., Quintana, D., Gray, M., Felmingham, K., Brown, K., Gatt, J. (2010). Impact of Depression and Antidepressant Treatment on Heart Rate Variability: A Review and Meta-Analysis. Biological Psychiatry, 67(11), 1067-1074. [More Information]
  • Gatt, J., Williams, L., Schofield, P., Dobson-Stone, C., Paul, R., Grieve, S., Clark, R., Gordon, E., Nemeroff, C. (2010). Impact of the HTR3A Gene With Early Life Trauma on Emotional Brain Networks and Depressed Mood. Depression and Anxiety, 27(8), 752-759. [More Information]
  • Wacker, J., Gatt, J. (2010). Resting posterior versus frontal delta/theta EEG activity is associated with extraversion and the COMT VAL(158)MET polymorphism. Neuroscience Letters, 478(2), 88-92. [More Information]

2009

  • Williams, L., Gatt, J., Schofield, P., Olivieri, G., Peduto, A., Gordon, E. (2009). 'Negativity bias' in risk for depression and anxiety: Brain-body fear circuitry correlates, 5-HTT-LPR and early life stress. NeuroImage, 47(3), 804-814. [More Information]
  • Williams, L., Gatt, J., Kuan, S., Dobson-Stone, C., Paul, R., Palmer, D., Song, L., Costa, P., Schofield, P., Gordon, E. (2009). A Polymorphism of the MAOA Gene is Associated with Emotional Brain Markers and Personality Traits on an Antisocial Index. Neuropsychopharmacology, 34(7), 1797-1809. [More Information]
  • Joffe, R., Gatt, J., Kemp, A., Grieve, S., Dobson-Stone, C., Kuan, S., Schofield, P., Gordon, E., Williams, L. (2009). Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness. Human Brain Mapping, 30(4), 1246-1256. [More Information]
  • Schofield, P., Williams, L., Paul, R., Gatt, J., Brown, K., Luty, A., Cooper, N., Grieve, S., Dobson-Stone, C., Morris, C., Kuan, S., Gordon, E. (2009). Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: Evidence from cognition, the P300 and fronto-hippocampal systems. Biological Psychology, 80(2), 176-188. [More Information]
  • Gatt, J., Nemeroff, C., Dobson-Stone, C., Paul, R., Bryant, R., Schofield, P., Gordon, E., Kemp, A., Williams, L. (2009). Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Molecular Psychiatry, 14(7), 681-695. [More Information]

2008

  • Gatt, J., Kuan, S., Dobson-Stone, C., Paul, R., Joffe, R., Kemp, A., Gordon, E., Schofield, P., Williams, L. (2008). Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity. Biological Psychology, 79(2), 275-284. [More Information]
  • Williams, L., Gatt, J., Hatch, A., Palmer, D., Nagy, M., Rennie, C., Cooper, N., Morris, C., Grieve, S., Dobson-Stone, C., Gordon, E., et al (2008). The integrate model of emotion, thinking and self regulation: an application to the "paradox of aging". Journal of Integrative Neuroscience, 7(3), 367-404. [More Information]
  • Gatt, J. (2008). The Role of Personality in Disease: Detection and Prevention. Germany: VDM Verlag Dr Muller.

2007

  • Gatt, J., Clark, C., Kemp, A., Liddell, B., Dobson-Stone, C., Kuan, S., Schofield, P., Williams, L. (2007). A genotype-endophenotype-phenotype path model of depressed mood: integrating cognitive and emotional markers. Journal of Integrative Neuroscience, 6(1), 75-104. [More Information]
  • Paul, R., Schofield, P., Gordon, E., Kuan, S., Williams, L., Dobson-Stone, C., Gatt, J. (2007). Genotypes and neural binding in negative affect: The contribution of genetic polymorphisms to 40 hz gamma phase synchrony. 62nd Annual Convention and Scientific Program SOBP, United States: Elsevier Science.
  • Gordon, E., Liddell, B., Brown, K., Bryant, R., Clark, C., Das, P., Dobson-Stone, C., Falconer, E., Felmingham, K., Flynn, G., Gatt, J., Harris, A., Hermens, D., Hopkinson, P., Kemp, A., Kuan, S., Lazzaro, I., Rennie, C., Whitford, T., Williams, L., et al (2007). Integrating objective gene-brain-behavior markers of psychiatric disorders. Journal of Integrative Neuroscience, 6(1), 1-34. [More Information]
  • Dobson-Stone, C., Gatt, J., Kuan, S., Grieve, S., Gordon, E., Williams, L., Schofield, P. (2007). Investigation of MCPH1 G37995C and ASPM A44871G polymorphisms and brain size in a healthy cohort. NeuroImage, 37(2), 394-400. [More Information]
  • Alexander, D., Williams, L., Gatt, J., Dobson-Stone, C., Kuan, S., Todd, E., Schofield, P., Cooper, N., Gordon, E. (2007). The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades. Biological Psychology, 75(3), 229-238. [More Information]

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