Dr Karen Cullen

Senior Lecturer
Anatomy & Histology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 2696
Fax +61 2 9351 2813

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Selected grants

2011

  • Microvascular breakdown: at the core of plaque and tangle pathology in Alzheimers disease; Cullen K; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Microvascular breakdown: at the core of plaque and tangle pathology in Alzheimers disease; Cullen K; Judith Jane Mason and Harold Stannett Williams Memorial Foundation/Medical and Scientific Research Grants.

2009

  • Neuronal energy crisis in Alzheimers disease: Evidence from human neuropatholgy and cell culture models; Cullen K, Goldsbury C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Mitochondrial Dysfunction as an initiator of Cytoskeletal Abnormalities in Alzhiemer's Disease; Whiteman I, Cullen K, Goldsbury C; Judith Jane Mason and Harold Stannett Williams Memorial Foundation/Medical and Scientific Research Grants.
  • Multiphoton microscope for Cellular Imaging in Live Animals; Leamey C, Phillips W, Dampney R, Westbrook R, Morley J, Arabzadeh E, Dreher B, Solomon S, Protti D, McGregor I, King N, Hunt N, Keay K, Allen D, Koeppl C, Cullen K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2005

  • The microvascular basis of idiopathic (Alzheimer�s like) dementia; Cullen K, Hunt N; Sir Zelman Cowen Universities Fund/Project Grant.

2004

  • Astocyte factors in the initiation of Alzheimers disease; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Research Project p25 transgenic mice model for alzheimers disease - BLO #3390; O'Connor S, Cullen K; Pfizer Pty Ltd/Research Grants.

2000

  • Macromolecule extraction and analysis facility; Firth N, Cullen K; Clive & Vera Ramaciotti Foundation/Research Grant.
  • Inflammation and microvascular degeneration in Alzheimers disease: relationship to senile plaque progression and neurofibrillary degeneration.; Cullen K; Sir Zelman Cowen Universities Fund/Research Grant.

Selected publications

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Journals

  • Wu, W., Nicolazzo, J., Wen, L., Chung, R., Stankovic, R., Bao, B., Lim, C., Brew, B., Cullen, K., Guillemin, G. (2013). Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain. PLoS One, 8(4), 1-11. [More Information]
  • Romo, P., Madigan, M., Provis, J., Cullen, K. (2010). Differential effects of TGF-Beta and FGF-2 on in vitro proliferation and migration of primate retinal endothelial and Muller cells. Acta Ophthalmologica, 89(3), 1-6. [More Information]
  • Gregory-Roberts, E., Naismith, S., Cullen, K., Hickie, I. (2010). Electroconvulsive therapy-induced persistent retrograde amnesia: Could it be minimised by ketamine or other pharmacological approaches? Journal of Affective Disorders, 126(1 - Feb), 39-45. [More Information]
  • Chen, Y., Stankovic, R., Cullen, K., Meininger, V., Garner, B., Coggan, S., Grant, R., Brew, B., Guillemin, G. (2010). The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis. Neurotoxicity Research, 18(2), 132-142. [More Information]
  • Whiteman, I., Gervasio, O., Cullen, K., Guillemin, G., Jeong, E., Witting, P., Antao, S., Minamide, L., Bamburg, J., Goldsbury, C. (2009). Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. The Journal of Neuroscience, 29(41), 12994-13005. [More Information]
  • Buljan, V., Ivanova, E., Cullen, K. (2009). How calcium controls microtubule anisotropic phase formation in the presence of microtubule-associated proteins in vitro. Biochemical and Biophysical Research Communications, 381(2), 224-228. [More Information]
  • Rahman, A., Ting, K., Cullen, K., Braidy, N., Brew, B., Guillemin, G. (2009). The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS One, 4(7), e6344 - 1-e6344 - 15. [More Information]
  • Guillemin, G., Cullen, K., Lim, C., Smythe, G., Garner, B., Kapoor, V., Takikawa, O., Brew, B. (2007). Characterization of the kynurenine pathway in primary human neurons. The Journal of Neuroscience, 27(47), 12884-12892. [More Information]
  • Guillemin, G., Brew, B., Noonan, C., Knight, T., Smythe, G., Cullen, K. (2007). Mass spectrometric detection of quinolinic acid in microdissected Alzheimer disease plaques. International Congress Series, 1304, 404-408. [More Information]
  • Hardy, J., Cullen, K. (2006). Amyloid at the blood vessel wall. Nature Medicine, 12(7), 756-7. [More Information]
  • Cullen, K., Kócsi, Z., Stone, J. (2006). Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1786-1796. [More Information]
  • Cullen, K., Kocsi, Z., Stone, J. (2006). Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1786-1796.
  • Guillemin, G., Brew, B., Noonan, C., Takikawa, O., Cullen, K. (2005). Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus. Neuropathology and Applied Neurobiology, 31(4), 395-404. [More Information]
  • Guillemin, G., Brew, B., Noonan, C., Takikawa, O., Cullen, K. (2005). Indoleamine 2,3 dioxygenase and quinolinic acid in plaque and neurons in post-mortem brain tissue from Alzheimer’s disease and control cases. Neuropathology and Applied Neurobiology, 31, 395-404.
  • Cullen, K., Kocsi, Z., Stone, J. (2005). Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. Journal of Cerebral Blood Flow and Metabolism, 25(12), 1656-1667. [More Information]
  • Stankovic, R., Shingde, M., Cullen, K. (2005). The experimental toxicology of metallic mercury on the murine peripheral motor system: a novel method of assessing axon calibre spectra using the phrenic nerve. Journal of Neuroscience Methods, 147(2), 114-125. [More Information]

2013

  • Wu, W., Nicolazzo, J., Wen, L., Chung, R., Stankovic, R., Bao, B., Lim, C., Brew, B., Cullen, K., Guillemin, G. (2013). Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain. PLoS One, 8(4), 1-11. [More Information]

2010

  • Romo, P., Madigan, M., Provis, J., Cullen, K. (2010). Differential effects of TGF-Beta and FGF-2 on in vitro proliferation and migration of primate retinal endothelial and Muller cells. Acta Ophthalmologica, 89(3), 1-6. [More Information]
  • Gregory-Roberts, E., Naismith, S., Cullen, K., Hickie, I. (2010). Electroconvulsive therapy-induced persistent retrograde amnesia: Could it be minimised by ketamine or other pharmacological approaches? Journal of Affective Disorders, 126(1 - Feb), 39-45. [More Information]
  • Chen, Y., Stankovic, R., Cullen, K., Meininger, V., Garner, B., Coggan, S., Grant, R., Brew, B., Guillemin, G. (2010). The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis. Neurotoxicity Research, 18(2), 132-142. [More Information]

2009

  • Whiteman, I., Gervasio, O., Cullen, K., Guillemin, G., Jeong, E., Witting, P., Antao, S., Minamide, L., Bamburg, J., Goldsbury, C. (2009). Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. The Journal of Neuroscience, 29(41), 12994-13005. [More Information]
  • Buljan, V., Ivanova, E., Cullen, K. (2009). How calcium controls microtubule anisotropic phase formation in the presence of microtubule-associated proteins in vitro. Biochemical and Biophysical Research Communications, 381(2), 224-228. [More Information]
  • Rahman, A., Ting, K., Cullen, K., Braidy, N., Brew, B., Guillemin, G. (2009). The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS One, 4(7), e6344 - 1-e6344 - 15. [More Information]

2007

  • Guillemin, G., Cullen, K., Lim, C., Smythe, G., Garner, B., Kapoor, V., Takikawa, O., Brew, B. (2007). Characterization of the kynurenine pathway in primary human neurons. The Journal of Neuroscience, 27(47), 12884-12892. [More Information]
  • Guillemin, G., Brew, B., Noonan, C., Knight, T., Smythe, G., Cullen, K. (2007). Mass spectrometric detection of quinolinic acid in microdissected Alzheimer disease plaques. International Congress Series, 1304, 404-408. [More Information]

2006

  • Hardy, J., Cullen, K. (2006). Amyloid at the blood vessel wall. Nature Medicine, 12(7), 756-7. [More Information]
  • Cullen, K., Kócsi, Z., Stone, J. (2006). Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1786-1796. [More Information]
  • Cullen, K., Kocsi, Z., Stone, J. (2006). Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1786-1796.

2005

  • Guillemin, G., Brew, B., Noonan, C., Takikawa, O., Cullen, K. (2005). Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus. Neuropathology and Applied Neurobiology, 31(4), 395-404. [More Information]
  • Guillemin, G., Brew, B., Noonan, C., Takikawa, O., Cullen, K. (2005). Indoleamine 2,3 dioxygenase and quinolinic acid in plaque and neurons in post-mortem brain tissue from Alzheimer’s disease and control cases. Neuropathology and Applied Neurobiology, 31, 395-404.
  • Cullen, K., Kocsi, Z., Stone, J. (2005). Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. Journal of Cerebral Blood Flow and Metabolism, 25(12), 1656-1667. [More Information]
  • Stankovic, R., Shingde, M., Cullen, K. (2005). The experimental toxicology of metallic mercury on the murine peripheral motor system: a novel method of assessing axon calibre spectra using the phrenic nerve. Journal of Neuroscience Methods, 147(2), 114-125. [More Information]

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