Dr Karin Aubrey

Senior Hospital Scientist, Pain Management Research Institute, Kolling Institute of Medical Research L13, Royal North Shore Hospital & Senior Research Fellow, Northern Clinical School, University of Sydney

Telephone +61 2 9926 4961
Fax +61 2 9926 7105

Website Research Gate Profile
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Biographical details

2015 - present Senior Hospital Scientist, PMRI Kolling Institute, Northern Clinical School University of Sydney

2012-2014 Postdoctoral researcher PMRI, Kolling Institute, Northern Clinical School University of Sydney

2009-2011 AFM postdoctoral fellow, Ecole Normal Superieur, Paris

2007-2009 Fondation Medicale postdoctoral fellow, Ecole Normal Superieur, Paris

2005-2007 Marie-Curie IIF postdoctoral fellow, Ecole Normal Superieur, Paris

2004-2005 Research Assistant PMRI, University of Sydney

2004 PhD Medicine, Department of Pharmacology, University of Sydney with Robert Vandenberg 1999 Ba Science (Hons) University of Sydney

Research interests

Information is transmitted and processed in the human brain by roughly 100 billion interconnected cells called neurons, which communicate with each other using a combination of electrical and chemical signaling.

Although scientists began to get a clear understanding of electro-chemical signaling in the early 20th century basic questions still remain.These include how different chemicals affect and adjust signaling in each brain region, and how the electrical signal is shaped and integrated to produce the desired outgoing chemical signal.

A careful and thorough exploration of basic mechanisms governing neuronal signaling is an essential stepping-stone to unravel how the brain works and allow the development of safe and effective treatments for diseases of the nervous system.

My work is focused on understanding how the inhibitory neurotransmitters GABA and glycine are accumulated in neurons and how they shape and maintain the inhibitory signal.

The Neurobiology of Pain Laboritory is part of the Pain Management Research Institute at the Northern Clinical School of the University of Sydney. We are interested in presynpatic regulation of neurons in the dorsal horn of the the spinal cord where physiological and pathological pain signals first enter the CNS and where descending modulation occurs.

The main techniques used are: whole-cell patch clamp electrophysiology, primary cell culture and acute dissociation, fast drug application and drug/receptor interactions

Teaching and supervision

University of Sydney, Tutor in the Dept. of Pharmacology for PCOL2 and 3

University of Sydney, Tutor in the Dept. of Physiology for NEUR2001/3001 NeuroPapers Sessions

University of Sydney, Lecuturer for the Brain and Mind Sciences Masters BMRI5020 course

Current projects

Looking for Honours/Masters and PhD students to start in June/July 2016.

Are you interested in doing a project in neurobiology? Main techniques: Electrophysiology, Drug/Receptor interactions/ Spinal Cord physiology/ Inhibitory Neurotransmission/ Cell culture

If so, please contact me for details: karin.aubrey@sydney.edu.au

Previous Students:

2015, Honours Project: Calum Nicholson, Glutamine effects on inhibitory transmission in the spinal cord

2014, Summer Scholarship: Amanda Lieu, GABA IPSC rundown in the periducatal gray

Associations

Editor: Pharmacology Research and Perspectives

http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2052-1707/

Selected grants

2015

  • Presynaptic mechanisms that control the GABA and glycine balance in pain circuits; Aubrey K; University of Sydney/Early Career Researcher.

Selected publications

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Journals

  • Wang, L., Tu, P., Bonet, L., Aubrey, K., Supplisson, S. (2013). Cytosolic transmitter concentration regulates vesicle cycling at hippocampal GABAergic terminals. Neuron, 80(1), 143-158. [More Information]
  • Yang, Z., Aubrey, K., Alroy, I., Harvey, R., Vandenberg, R., Lynch, J. (2008). Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology, 76(8), 1014-1023. [More Information]
  • Rousseau, F., Aubrey, K., Supplisson, S. (2008). The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. The Journal of Neuroscience, 28(39), 9755-9768. [More Information]
  • Aubrey, K., Rossi, F., Ruivo, R., Alboni, S., Bellenchi, G., Le Goff, A., Gasnier, B., Supplisson, S. (2007). The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. The Journal of Neuroscience, 27(23), 6273-6281. [More Information]
  • Wiles, A., Pearlman, R., Rosvall, M., Aubrey, K., Vandenberg, R. (2006). N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry, 99(3), 781-786. [More Information]
  • Aubrey, K., Vandenberg, R., Clements, J. (2005). Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal, 89(3), 1657-1668. [More Information]
  • Vandenberg, R., Ju, P., Aubrey, K., Ryan, R., Mitrovic, A. (2004). Allosteric Modulation Of Neurotransmitter Transporters At Excitatory Synapses. European Journal of Pharmaceutical Sciences, 23(1), 1-11.
  • Ju, P., Aubrey, K., Vandenberg, R. (2004). Zn2+ Inhibits Glycine Transport By Glycine Transporter Subtype 1B. Journal of Biological Chemistry, 279(22), 22983-22991.
  • Pearlman, R., Aubrey, K., Vandenberg, R. (2003). Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry, 84(3), 592-601.
  • Vandenberg, R., Aubrey, K. (2001). Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion on Therapeutic Targets, 5, 507-518.
  • Aubrey, K., Vandenberg, R. (2001). N[3-(4-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology, 134(7), 1429-1436.

2013

  • Wang, L., Tu, P., Bonet, L., Aubrey, K., Supplisson, S. (2013). Cytosolic transmitter concentration regulates vesicle cycling at hippocampal GABAergic terminals. Neuron, 80(1), 143-158. [More Information]

2008

  • Yang, Z., Aubrey, K., Alroy, I., Harvey, R., Vandenberg, R., Lynch, J. (2008). Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology, 76(8), 1014-1023. [More Information]
  • Rousseau, F., Aubrey, K., Supplisson, S. (2008). The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. The Journal of Neuroscience, 28(39), 9755-9768. [More Information]

2007

  • Aubrey, K., Rossi, F., Ruivo, R., Alboni, S., Bellenchi, G., Le Goff, A., Gasnier, B., Supplisson, S. (2007). The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. The Journal of Neuroscience, 27(23), 6273-6281. [More Information]

2006

  • Wiles, A., Pearlman, R., Rosvall, M., Aubrey, K., Vandenberg, R. (2006). N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry, 99(3), 781-786. [More Information]

2005

  • Aubrey, K., Vandenberg, R., Clements, J. (2005). Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal, 89(3), 1657-1668. [More Information]

2004

  • Vandenberg, R., Ju, P., Aubrey, K., Ryan, R., Mitrovic, A. (2004). Allosteric Modulation Of Neurotransmitter Transporters At Excitatory Synapses. European Journal of Pharmaceutical Sciences, 23(1), 1-11.
  • Ju, P., Aubrey, K., Vandenberg, R. (2004). Zn2+ Inhibits Glycine Transport By Glycine Transporter Subtype 1B. Journal of Biological Chemistry, 279(22), 22983-22991.

2003

  • Pearlman, R., Aubrey, K., Vandenberg, R. (2003). Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry, 84(3), 592-601.

2001

  • Vandenberg, R., Aubrey, K. (2001). Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion on Therapeutic Targets, 5, 507-518.
  • Aubrey, K., Vandenberg, R. (2001). N[3-(4-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology, 134(7), 1429-1436.

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