Dr Karin Aubrey

Neurobiology of Pain Laboratory Head, Senior Hospital Scientist, Pain Management Research Institute, Kolling Institute of Medical Research L13, Royal North Shore Hospital &
Senior Research Fellow, Northern Clinical School, University of Sydney

Telephone +61 2 9926 4961
Fax +61 2 9926 7105

Website Research Gate Profile
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Biographical details

2015 - present Senior Hospital Scientist, Neurobiology of Pain Lab Head, PMRI, Kolling Institute, Northern Clinical School & University of Sydney

2012-2014 Postdoctoral researcher PMRI, Kolling Institute, Northern Clinical School University of Sydney

2009-2011 AFM postdoctoral fellow, Ecole Normal Superieur, Paris

2007-2009 Fondation Medicale postdoctoral fellow, Ecole Normal Superieur, Paris

2005-2007 Marie-Curie IIF postdoctoral fellow, Ecole Normal Superieur, Paris

2004-2005 Research Assistant PMRI, University of Sydney

2004 PhD Medicine, Department of Pharmacology, University of Sydney with Robert Vandenberg 1999 Ba Science (Hons) University of Sydney

Research interests

Pain is a complex experience that balances information from many parts of our brain including sensory and emotional centres. How the different brain regions fit together, and what role each region plays in the pain experience is still unclear and represents a major challenge in understanding and treating pain.

The goal of our research is to understand the building blocks involved in shaping pain at a molecular and cellular level in order to identify specialised pain-o-centric units that can be targeted by new classes of drugs that will work better and have less side-effects than current treatments.

The Neurobiology of Pain Laboratory is part of the Pain Management Research Institute at the Northern Clinical School of the University of Sydney. We currently have projects investigating the descending pain pathway, changes in the spinal cord during chronic pain and regulation of inhibitory transmission.

The main techniques used are: whole-cell patch clamp electrophysiology, primary cell culture and acute dissociation, fast drug application and animal models of pain.

Teaching and supervision

University of Sydney, Lecuturer for the Brain and Mind Sciences Masters BMRI5020 course

University of Sydney, Lecuturer for the Dept. Pharmacology PCOL3033 course

University of Sydney, Tutor in the Dept. of Pharmacology for PCOL2 and 3

University of Sydney, Tutor in the Dept. of Physiology for NEUR2001/3006 NeuroPapers Sessions

Current projects

Currently looking for Honours/Masters and PhD students!

Are you interested in doing a project in neurobiology? Main techniques: Electrophysiology, Drug/Receptor interactions/ Spinal Cord physiology/ Inhibitory Neurotransmission/ Cell culture

If so, please contact me for details: karin.aubrey@sydney.edu.au

Previous Students:

2017, Honours Project: Sebastian Stefani, Balance of inhibitory transmission in spinal cord neurons

2017, TSP project: Sam Gilbert, Modulation of T-type calcium channels in sensory neurons

Haipei Zou, Spinal cord targets of descending axons from the midbrain

2016, Summer Scholarship: Sai Murali, Modulation of T-type calcium channels in sensory neurons

2015, Honours Project: Calum Nicholson, Glutamine effects on inhibitory transmission in the spinal cord

2014, Summer Scholarship: Amanda Lieu, GABA IPSC rundown in the periducatal gray

Associations

Editor: Pharmacology Research and Perspectives

http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2052-1707/

Selected grants

2018

  • Pain Management Research Centre grant - Aubrey; Aubrey K; Pain Management Research Institute Ltd/Research Support.

2015

  • Presynaptic mechanisms that control the GABA and glycine balance in pain circuits; Aubrey K; University of Sydney/Early Career Researcher.

Selected publications

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Journals

  • Aubrey, K., Supplisson, S. (2018). Heterogeneous Signaling at GABA and Glycine Co-releasing Terminals. Frontiers in Synaptic Neuroscience, 10, 1-13. [More Information]
  • Aubrey, K., Drew, G., Jeong, H., Lau, B., Vaughan, C. (2017). Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses. Journal of Physiology, 595(1), 165-178. [More Information]
  • Aubrey, K. (2016). Presynaptic control of inhibitory neurotransmitter content in VIAAT containing synaptic vesicles. Neurochemistry International, 98, 94-102. [More Information]
  • Wang, L., Tu, P., Bonet, L., Aubrey, K., Supplisson, S. (2013). Cytosolic transmitter concentration regulates vesicle cycling at hippocampal GABAergic terminals. Neuron, 80(1), 143-158. [More Information]
  • Yang, Z., Aubrey, K., Alroy, I., Harvey, R., Vandenberg, R., Lynch, J. (2008). Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology, 76(8), 1014-1023. [More Information]
  • Rousseau, F., Aubrey, K., Supplisson, S. (2008). The glycine transporter Glyt2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. Journal of Neuroscience, 28(39), 9755-9768. [More Information]
  • Aubrey, K., Rossi, F., Ruivo, R., Alboni, S., Bellenchi, G., Le Goff, A., Gasnier, B., Supplisson, S. (2007). The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. Journal of Neuroscience, 27(23), 6273-6281. [More Information]
  • Wiles, A., Pearlman, R., Rosvall, M., Aubrey, K., Vandenberg, R. (2006). N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry, 99(3), 781-786. [More Information]
  • Aubrey, K., Vandenberg, R., Clements, J. (2005). Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal, 89(3), 1657-1668. [More Information]
  • Vandenberg, R., Ju, P., Aubrey, K., Ryan, R., Mitrovic, A. (2004). Allosteric Modulation Of Neurotransmitter Transporters At Excitatory Synapses. European Journal of Pharmaceutical Sciences, 23(1), 1-11. [More Information]
  • Ju, P., Aubrey, K., Vandenberg, R. (2004). Zn2+ Inhibits Glycine Transport By Glycine Transporter Subtype 1B. Journal of Biological Chemistry, 279(22), 22983-22991. [More Information]
  • Pearlman, R., Aubrey, K., Vandenberg, R. (2003). Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry, 84(3), 592-601. [More Information]
  • Vandenberg, R., Aubrey, K. (2001). Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion on Therapeutic Targets, 5, 507-518.
  • Aubrey, K., Vandenberg, R. (2001). N[3-(4-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology, 134(7), 1429-1436. [More Information]

2018

  • Aubrey, K., Supplisson, S. (2018). Heterogeneous Signaling at GABA and Glycine Co-releasing Terminals. Frontiers in Synaptic Neuroscience, 10, 1-13. [More Information]

2017

  • Aubrey, K., Drew, G., Jeong, H., Lau, B., Vaughan, C. (2017). Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses. Journal of Physiology, 595(1), 165-178. [More Information]

2016

  • Aubrey, K. (2016). Presynaptic control of inhibitory neurotransmitter content in VIAAT containing synaptic vesicles. Neurochemistry International, 98, 94-102. [More Information]

2013

  • Wang, L., Tu, P., Bonet, L., Aubrey, K., Supplisson, S. (2013). Cytosolic transmitter concentration regulates vesicle cycling at hippocampal GABAergic terminals. Neuron, 80(1), 143-158. [More Information]

2008

  • Yang, Z., Aubrey, K., Alroy, I., Harvey, R., Vandenberg, R., Lynch, J. (2008). Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology, 76(8), 1014-1023. [More Information]
  • Rousseau, F., Aubrey, K., Supplisson, S. (2008). The glycine transporter Glyt2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. Journal of Neuroscience, 28(39), 9755-9768. [More Information]

2007

  • Aubrey, K., Rossi, F., Ruivo, R., Alboni, S., Bellenchi, G., Le Goff, A., Gasnier, B., Supplisson, S. (2007). The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. Journal of Neuroscience, 27(23), 6273-6281. [More Information]

2006

  • Wiles, A., Pearlman, R., Rosvall, M., Aubrey, K., Vandenberg, R. (2006). N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry, 99(3), 781-786. [More Information]

2005

  • Aubrey, K., Vandenberg, R., Clements, J. (2005). Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal, 89(3), 1657-1668. [More Information]

2004

  • Vandenberg, R., Ju, P., Aubrey, K., Ryan, R., Mitrovic, A. (2004). Allosteric Modulation Of Neurotransmitter Transporters At Excitatory Synapses. European Journal of Pharmaceutical Sciences, 23(1), 1-11. [More Information]
  • Ju, P., Aubrey, K., Vandenberg, R. (2004). Zn2+ Inhibits Glycine Transport By Glycine Transporter Subtype 1B. Journal of Biological Chemistry, 279(22), 22983-22991. [More Information]

2003

  • Pearlman, R., Aubrey, K., Vandenberg, R. (2003). Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry, 84(3), 592-601. [More Information]

2001

  • Vandenberg, R., Aubrey, K. (2001). Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion on Therapeutic Targets, 5, 507-518.
  • Aubrey, K., Vandenberg, R. (2001). N[3-(4-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology, 134(7), 1429-1436. [More Information]

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