Dr Karin Aubrey

Senior Hospital Scientist, Pain Management Research Institute, Kolling Institute of Medical Research L13, Royal North Shore Hospital & Senior Research Fellow, Northern Clinical School, University of Sydney

Telephone +61 2 9926 4961
Fax +61 2 9926 7105

Website Research Gate Profile
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Biographical details

2015 - present Senior Hospital Scientist, PMRI Kolling Institute, Northern Clinical School University of Sydney

2012-2014 Postdoctoral researcher PMRI, Kolling Institute, Northern Clinical School University of Sydney

2009-2011 AFM postdoctoral fellow, Ecole Normal Superieur, Paris

2007-2009 Fondation Medicale postdoctoral fellow, Ecole Normal Superieur, Paris

2005-2007 Marie-Curie IIF postdoctoral fellow, Ecole Normal Superieur, Paris

2004-2005 Research Assistant PMRI, University of Sydney

2004 PhD Medicine, Department of Pharmacology, University of Sydney with Robert Vandenberg 1999 Ba Science (Hons) University of Sydney

Research interests

Information is transmitted and processed in the human brain by roughly 100 billion interconnected cells called neurons, which communicate with each other using a combination of electrical and chemical signaling.

Although scientists began to get a clear understanding of electro-chemical signaling in the early 20th century basic questions still remain.These include how different chemicals affect and adjust signaling in each brain region, and how the electrical signal is shaped and integrated to produce the desired outgoing chemical signal.

A careful and thorough exploration of basic mechanisms governing neuronal signaling is an essential stepping-stone to unravel how the brain works and allow the development of safe and effective treatments for diseases of the nervous system.

I have spent the last 10 years studying neurobiology in Australia (PhD & postdoctoral) and France (postdoctoral) and my work was focused on understanding how the chemical neurotransmitters GABA and glycine are accumulated in neurons and how they shape and maintain the inhibitory signal.

I have recently returned to Australia to continue my work in the Pain Management Research Institute at the Northern Clinical School of the University of Sydney where I have am looking at presynpatic regulation of neurons in regions of brain that transmit physiological and pathological pain signals including the spinal cord, thalamus and periaquiductal gray.

Teaching and supervision

University of Sydney, Pharmacology tutor for PCOL2 and 3

University of Sydney, Physiology tutor for NeuroPapers Sessions

Current projects

Honours Project: Calum Nicholson, Glutamine effects on inhibitory transmission in the spinal cord

Associations

Editor: Pharmacology Research and Perspectives

http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2052-1707/

Selected grants

2015

  • Presynaptic mechanisms that control the GABA and glycine balance in pain circuits; Aubrey K; University of Sydney/Early Career Researcher.

Selected publications

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Journals

  • Yang, Z., Aubrey, K., Alroy, I., Harvey, R., Vandenberg, R., Lynch, J. (2008). Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology, 76(8), 1014-1023. [More Information]
  • Rousseau, F., Aubrey, K., Supplisson, S. (2008). The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. The Journal of Neuroscience, 28(39), 9755-9768. [More Information]
  • Aubrey, K., Rossi, F., Ruivo, R., Alboni, S., Bellenchi, G., Le Goff, A., Gasnier, B., Supplisson, S. (2007). The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. The Journal of Neuroscience, 27(23), 6273-6281. [More Information]
  • Wiles, A., Pearlman, R., Rosvall, M., Aubrey, K., Vandenberg, R. (2006). N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry, 99(3), 781-786. [More Information]
  • Aubrey, K., Vandenberg, R., Clements, J. (2005). Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal, 89(3), 1657-1668. [More Information]
  • Vandenberg, R., Ju, P., Aubrey, K., Ryan, R., Mitrovic, A. (2004). Allosteric Modulation Of Neurotransmitter Transporters At Excitatory Synapses. European Journal of Pharmaceutical Sciences, 23(1), 1-11.
  • Ju, P., Aubrey, K., Vandenberg, R. (2004). Zn2+ Inhibits Glycine Transport By Glycine Transporter Subtype 1B. Journal of Biological Chemistry, 279(22), 22983-22991.
  • Pearlman, R., Aubrey, K., Vandenberg, R. (2003). Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry, 84(3), 592-601.
  • Vandenberg, R., Aubrey, K. (2001). Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion on Therapeutic Targets, 5, 507-518.
  • Aubrey, K., Vandenberg, R. (2001). N[3-(4-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology, 134(7), 1429-1436.

2008

  • Yang, Z., Aubrey, K., Alroy, I., Harvey, R., Vandenberg, R., Lynch, J. (2008). Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology, 76(8), 1014-1023. [More Information]
  • Rousseau, F., Aubrey, K., Supplisson, S. (2008). The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. The Journal of Neuroscience, 28(39), 9755-9768. [More Information]

2007

  • Aubrey, K., Rossi, F., Ruivo, R., Alboni, S., Bellenchi, G., Le Goff, A., Gasnier, B., Supplisson, S. (2007). The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. The Journal of Neuroscience, 27(23), 6273-6281. [More Information]

2006

  • Wiles, A., Pearlman, R., Rosvall, M., Aubrey, K., Vandenberg, R. (2006). N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry, 99(3), 781-786. [More Information]

2005

  • Aubrey, K., Vandenberg, R., Clements, J. (2005). Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal, 89(3), 1657-1668. [More Information]

2004

  • Vandenberg, R., Ju, P., Aubrey, K., Ryan, R., Mitrovic, A. (2004). Allosteric Modulation Of Neurotransmitter Transporters At Excitatory Synapses. European Journal of Pharmaceutical Sciences, 23(1), 1-11.
  • Ju, P., Aubrey, K., Vandenberg, R. (2004). Zn2+ Inhibits Glycine Transport By Glycine Transporter Subtype 1B. Journal of Biological Chemistry, 279(22), 22983-22991.

2003

  • Pearlman, R., Aubrey, K., Vandenberg, R. (2003). Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry, 84(3), 592-601.

2001

  • Vandenberg, R., Aubrey, K. (2001). Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion on Therapeutic Targets, 5, 507-518.
  • Aubrey, K., Vandenberg, R. (2001). N[3-(4-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology, 134(7), 1429-1436.

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