Associate Professor Karl Ng

Associate Professor
Medicine, Central Clinical School

Telephone +61 2 9467 5900
Fax +61 2 9467 5901

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Biographical details

Dr Ng is a Conjoint Associate Professor at the Northern Clinical School, University of Sydney, and Senior Staff Specialist Consultant Neurologist Royal North Shore Hospital. He completed his medical degree with First Class Honours at the University of New South Wales, and attained accreditation in Neurology from the Royal Australasian College of Physicians. He has undertaken a 3 year post-fellowship training in Clinical Neurophysiology at the prestigious National Hospital for Neurology and Neurosurgery, Queen Square, London culminating in accreditation of a second specialty in the UK in this area. He completed a PhD thesis in the field of peripheral nerve axonal excitability.

Dr Ng is a fellow of the Royal College of Physicians (London), Royal Australasian College of Physicians, and active in the Australian and New Zealand Association of Neurologists (ANZAN) where he is a councillor of the association and committee member of the EEG - Clinical Neurophysiology interest group. He is head of the Department of Clinical Neurophysiology at Royal North Shore Hospital, and has organised specialty training conferences in neurophysiology for the Australian association. He serves on the directors' board of the charitable Brain Foundation and is the NSW representative of the Australian and New Zealand Headache Society.He has more than 50 publications in international peer-reviewed journals, and is an invited reviewer for these learned societies. He is also an editorial advisory board member of VirtualMedicalCentre.

Dr Ng is in private practice at Sydney North Neurology and Neurophysiology, Crows Nest.

www.sydneynorthneurology.com.au

Research interests

Currently, his main research interest is in peripheral neuromuscular disorders, especially the field of axonal excitability which is the subject of a completed doctoral thesis.This includes studying both peripheral neuropathic, as well as central nervous system disorders such as multiple sclerosis for their peripheral adaptive plasticity.

Specific practice interests include clinical neurophysiology, and the medical uses of an botulinum toxin for medical conditions including movement disorders, pain syndromes such as chronic migraine prevention, and for hypersecretory disorders such as hyperhidrosis.

Teaching and supervision

Active teaching in the following: Sydney Medical School - Northern and Central Clinical School, Brain School - Australian and New Zealand Association of Neurologists (ANZAN),Neurophysiology Fellow - Royal North Shore Hospital, the ANZAN annual EMG workshop (principal organiser) and ANZAN Basic Physician Training Program - Royal North Shore Hospital. Supervision/mentoring of PhD/MPhil students. Regular speaking engagements are undertaken overseas and these include invited lectures in the Asia Pacific Region and within the Hoc Mai University of Sydney - Vietnam collaboration.

Current projects

Nerve and muscle excitabilty in neuromuscular disorders - with David Burke

Mulitple sclerosis - radiological phenotypic correlations; antibody mediated pain syndromes - with John Parratt

Chronic headache syndromes, cervicogenic elements and assessment instruments - Trudy Rebbeck

Associations

Australian and New Zealand Association of Neurologists - councillor and director

Brain Foundation - director

Royal Australian College of Physicians (RACP) - fellow

Royal College of Physicians (UK) - fellow

Australian and New Zealand Headache Society - NSW representative

International Hyperhidrosis Society - member

Association of Neurophysiological Technicians of Australia - DDC AG member

NHMRC project grant and fellowship recipient

RACP GSK fellowship in Neurology

Pfizer Neurosciences Research Grant

Awards and honours

Bachelor degree in Medicine and Surgery - first class honours

Doctor of Philosophy - University of Sydney

Australian and New Zealand Association of Neurologists - PK Thomas fellowship to Royal Free Hospital, London

PhD and master's project opportunities

International links

China

(Huashan Hospital, Fudan University, Shanghai) Professor Xiang-Jun Chen

United Kingdom

(Institute of Neurology, University College London) Professor Hugh Bostock

Selected grants

2013

  • Nerve and muscle excitability into neurological/ neuromuscular disorders; Ng K; Royal North Shore Hospital - The Corner Shop/Research Support.

2008

  • Neural plasticity following lesions of the central nervous system in Multiple Sclerosis; Burke D, Ng K, Pollard J, Ng K; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Plastic peripheral nerve changes of axonal exitability in multiple sclerosis and other central disorders; Ng K, Burke D, Pollard J; Pfizer Neuro Science Res Grants/Research Grant.
  • Abnormalities of the excitability of peripheral nerve axons in multiple sclerosis and other disorder; Ng K; Royal Australasian College of Physicians/Research Grant.

Selected publications

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Journals

  • Hafner, J., Lee, G., Joester, J., Lynch, M., Barnes, E., Wrigley, P., Ng, K. (2015). Thermal quantitative sensory testing: A study of 101 control subjects. Journal of Clinical Neuroscience, 22(3), 588-591. [More Information]
  • Liang, C., Howells, J., Kennerson, M., Nicholson, G., Burke, D., Ng, K. (2014). Axonal excitability in X-linked dominant Charcot Marie Tooth disease. Clinical Neurophysiology, 125(6), 1261-1269. [More Information]
  • Geevasinga, N., Burrell, J., Hibbert, M., Vucic, S., Ng, K. (2014). C9ORF72 familial motor neuron disease - frontotemporal dementia associated with lung adenocarcinoma and anti-Ma2/Ta antibodies: a chance association. European Journal of Neurology, 21(4), e31-e33. [More Information]
  • Geevasinga, N., Archer, J., Ng, K. (2014). Choking, asphyxiation and the insular seizure. Journal of Clinical Neuroscience, 21(4), 688-689. [More Information]
  • Liang, C., Ng, K. (2014). Comparing axonal excitability in past polio to amyotrophic lateral sclerosis. Muscle and Nerve, 50, 602-604. [More Information]
  • Ng, K. (2014). MADSAM neuropathy: An unusual cause of pseudoathetosis. Neurology, 83(3), 291. [More Information]
  • Hafner, J., Kumar, K., Mulligan, S., Ng, K. (2014). Multifocal central nervous system demyelination and Lhermitte's phenomenon secondary to combination chemotherapy for chronic lymphocytic leukaemia. Journal of the Neurological Sciences, 338(1-2), 218-219. [More Information]
  • Ng, K., Murray, N., Burke, D. (2014). Peripheral nerve excitability before and after liver transplant. Muscle and Nerve, 49(4), 615-616. [More Information]
  • Ng, K., Kumar, K., Sue, C., Burke, D. (2013). Axonal excitability during ischemia in MELAS. Muscle and Nerve, 47(5), 762-765. [More Information]
  • Ng, K., Howells, J., Pollard, J., Burke, D. (2013). Different mechanisms underlying changes in excitability of peripheral nerve sensory and motor axons in multiple sclerosis. Muscle and Nerve, 47(1), 53-60. [More Information]
  • Geevasinga, N., Day, B., Ng, K. (2013). Multifocal motor neuropathy and muscle hypertrophy. Internal Medicine Journal, 43(11), 1237-1239. [More Information]
  • Geevasinga, N., Simon, N., Collins,, S., Buckland, M., Ng, K. (2013). Sporadic Creutzfeldt–Jakob disease presenting as spastic paraparesis. European Journal of Neurology, 20(5), e73-e74. [More Information]
  • Kumar, K., Blair, N., Vandebona, H., Liang, C., Ng, K., Sharpe, D., Grünewald, A., Gölnitz, U., Saviouk, V., Rolfs, A., Sue, C., et al (2013). Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia. Journal of Neurology, 260(10), 2516-2522. [More Information]
  • Kumar, K., Sue, C., Burke, D., Ng, K. (2012). Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation - A neurophysiological study using excitability techniques. Clinical Neurophysiology, 123(7), 1454-1459. [More Information]
  • Ha, A., Parratt, K., Rendtorff, N., Lodahl, M., Ng, K., Rowe, D., Sue, C., Hayes, M., Tranebjaerg, L., Fung, V. (2012). The Phenotypic Spectrum of Dystonia in Mohr-Tranebjaerg Syndrome. Movement Disorders, 27(8), 1034-1040. [More Information]
  • Ng, K., Lee, G., Joester, J., Lynch, M., Barnes, E. (2012). Thermal quantitative sensory testing (QST)-A normative study of 100 controls. Clinical Neurophysiology, 123, e76-e76.
  • Ng, K., Kumar, K., Brew, B., Burke, D. (2011). Axonal excitability in viral polyneuropathy and nucleoside neuropathy in HIV patients. Journal of Neurology, Neurosurgery and Psychiatry, 82(9), 978-980. [More Information]
  • Kumar, K., Liang, C., Needham, M., Burke, D., Sue, C., Ng, K. (2011). Axonal hyperpolarization in inclusion-body myopathy, paget disease of the bone, and frontotemporal dementia (IBMPFD). Muscle and Nerve, 44(2), 191-196. [More Information]
  • Chang, F., Berman, Y., Buckland, M., MacKinlay, N., McGlade, A., Collins, S., Ng, K. (2011). Genetic prion disease-associated myelodysplasia and SIADH in siblings. European Journal of Neurology, 18(12), e149-e150. [More Information]
  • Simister, R., Ng, K., Lang, B., Beckles, M., Chao, D., McCabe, D. (2011). Sequential fluctuating paraneoplastic ocular flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small-cell lung cancer. Journal of Neurology, Neurosurgery and Psychiatry, 82(3), 344-346. [More Information]
  • Kumar, K., Ng, K., Vandebona, H., Davis, M., Sue, C. (2010). A novel CLCN1 mutation (G1652A) causing a mild phenotype of Thomsen disease. Muscle and Nerve, 41(3), 412-415. [More Information]
  • Chan, Q., Ng, K., Vandervord, J. (2010). Critical illness polyneuropathy in patients with major burn injuries. Eplasty: open access journal of plastic surgery committer to the free exchange of knowledge in a global community, 10, 568-574. [More Information]
  • Kumar, K., Ng, K. (2010). Don't hold your breath: anoxic convulsions from coupled hyperventilation-underwater breath-holding. Medical Journal of Australia, 192(11), 663-664. [More Information]
  • Rejdak, K., Petzold, A., Ng, K., Afra, J., Dujmovic, I., Stelmasiak, Z., Ryglewicz, D., Kwiecinski, H., Grisold, W., Vecsei, L., et al (2010). Neurology training around the world: asking the trainees. Lancet Neurology, 9(1), 32-3. [More Information]
  • Ng, K., Winter, S., Sue, C., Burke, D. (2010). Preserved motor axonal membrane potential in mitochondrial disease. Journal of Neurology, Neurosurgery and Psychiatry, 81(8), 844-846. [More Information]
  • Kumar, K., Ng, K. (2010). Reduced facial nerve hyperexcitability from contralateral cerebral stroke in hemifacial spasm. Movement Disorders, 25(9), 1310-2. [More Information]
  • Kumar, K., Needham, M., Mina, K., Davis, M., Brewer, J., Staples, C., Ng, K., Sue, C., Mastaglia, F. (2010). Two Australian families with inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia: novel clinical and genetic findings. Neuromuscular Disorders, 20(5), 330-334. [More Information]
  • Leong, G., Gorrie, C., Ng, K., Rutkowski, S., Waite, P. (2009). Electrical perceptual threshold testing: a validation study. Journal of Spinal Cord Medicine, 32(2), 140-146. [More Information]
  • Ng, K., Howells, J., Pollard, J., Burke, D. (2008). Up-regulation of slow K+ channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosis. Brain, 131(11), 3062-3071. [More Information]
  • Ng, K., Lin, C., Murray, N., Burroughs, A., Bostock, H. (2007). Conduction and excitability properties of peripheral nerves in end-stage liver disease. Muscle and Nerve, 35(6), 730-738. [More Information]
  • Ng, K., Burke, D. (2007). Nerve Excitability Studies in the Present Era. Advances in Clinical Neuroscience & Rehabilitation, 7(5), 29-30.
  • Gunja, N., Dowsett, R., Ng, K. (2007). Raw salmon or red herring: ascending paralysis with suspected seafood poisoning. Medical Journal of Australia, 187(8), 468-469. [More Information]
  • Ng, K., Jones, S. (2007). The ‘‘enhanced N35’’ somatosensory evoked potential: its associations and potential utility in the clinical evaluation of dystonia and myoclonus. Journal of Neurology, 254(1), 46-52. [More Information]
  • Spratt, N., Wang, Y., Levi, C., Ng, K., Evans, M., Fisher, J. (2003). A prospective study of predictors of prolonged hospital stay and disability after stroke. Journal of Clinical Neuroscience, 10(6), 665-669. [More Information]

2015

  • Hafner, J., Lee, G., Joester, J., Lynch, M., Barnes, E., Wrigley, P., Ng, K. (2015). Thermal quantitative sensory testing: A study of 101 control subjects. Journal of Clinical Neuroscience, 22(3), 588-591. [More Information]

2014

  • Liang, C., Howells, J., Kennerson, M., Nicholson, G., Burke, D., Ng, K. (2014). Axonal excitability in X-linked dominant Charcot Marie Tooth disease. Clinical Neurophysiology, 125(6), 1261-1269. [More Information]
  • Geevasinga, N., Burrell, J., Hibbert, M., Vucic, S., Ng, K. (2014). C9ORF72 familial motor neuron disease - frontotemporal dementia associated with lung adenocarcinoma and anti-Ma2/Ta antibodies: a chance association. European Journal of Neurology, 21(4), e31-e33. [More Information]
  • Geevasinga, N., Archer, J., Ng, K. (2014). Choking, asphyxiation and the insular seizure. Journal of Clinical Neuroscience, 21(4), 688-689. [More Information]
  • Liang, C., Ng, K. (2014). Comparing axonal excitability in past polio to amyotrophic lateral sclerosis. Muscle and Nerve, 50, 602-604. [More Information]
  • Ng, K. (2014). MADSAM neuropathy: An unusual cause of pseudoathetosis. Neurology, 83(3), 291. [More Information]
  • Hafner, J., Kumar, K., Mulligan, S., Ng, K. (2014). Multifocal central nervous system demyelination and Lhermitte's phenomenon secondary to combination chemotherapy for chronic lymphocytic leukaemia. Journal of the Neurological Sciences, 338(1-2), 218-219. [More Information]
  • Ng, K., Murray, N., Burke, D. (2014). Peripheral nerve excitability before and after liver transplant. Muscle and Nerve, 49(4), 615-616. [More Information]

2013

  • Ng, K., Kumar, K., Sue, C., Burke, D. (2013). Axonal excitability during ischemia in MELAS. Muscle and Nerve, 47(5), 762-765. [More Information]
  • Ng, K., Howells, J., Pollard, J., Burke, D. (2013). Different mechanisms underlying changes in excitability of peripheral nerve sensory and motor axons in multiple sclerosis. Muscle and Nerve, 47(1), 53-60. [More Information]
  • Geevasinga, N., Day, B., Ng, K. (2013). Multifocal motor neuropathy and muscle hypertrophy. Internal Medicine Journal, 43(11), 1237-1239. [More Information]
  • Geevasinga, N., Simon, N., Collins,, S., Buckland, M., Ng, K. (2013). Sporadic Creutzfeldt–Jakob disease presenting as spastic paraparesis. European Journal of Neurology, 20(5), e73-e74. [More Information]
  • Kumar, K., Blair, N., Vandebona, H., Liang, C., Ng, K., Sharpe, D., Grünewald, A., Gölnitz, U., Saviouk, V., Rolfs, A., Sue, C., et al (2013). Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia. Journal of Neurology, 260(10), 2516-2522. [More Information]

2012

  • Kumar, K., Sue, C., Burke, D., Ng, K. (2012). Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation - A neurophysiological study using excitability techniques. Clinical Neurophysiology, 123(7), 1454-1459. [More Information]
  • Ha, A., Parratt, K., Rendtorff, N., Lodahl, M., Ng, K., Rowe, D., Sue, C., Hayes, M., Tranebjaerg, L., Fung, V. (2012). The Phenotypic Spectrum of Dystonia in Mohr-Tranebjaerg Syndrome. Movement Disorders, 27(8), 1034-1040. [More Information]
  • Ng, K., Lee, G., Joester, J., Lynch, M., Barnes, E. (2012). Thermal quantitative sensory testing (QST)-A normative study of 100 controls. Clinical Neurophysiology, 123, e76-e76.

2011

  • Ng, K., Kumar, K., Brew, B., Burke, D. (2011). Axonal excitability in viral polyneuropathy and nucleoside neuropathy in HIV patients. Journal of Neurology, Neurosurgery and Psychiatry, 82(9), 978-980. [More Information]
  • Kumar, K., Liang, C., Needham, M., Burke, D., Sue, C., Ng, K. (2011). Axonal hyperpolarization in inclusion-body myopathy, paget disease of the bone, and frontotemporal dementia (IBMPFD). Muscle and Nerve, 44(2), 191-196. [More Information]
  • Chang, F., Berman, Y., Buckland, M., MacKinlay, N., McGlade, A., Collins, S., Ng, K. (2011). Genetic prion disease-associated myelodysplasia and SIADH in siblings. European Journal of Neurology, 18(12), e149-e150. [More Information]
  • Simister, R., Ng, K., Lang, B., Beckles, M., Chao, D., McCabe, D. (2011). Sequential fluctuating paraneoplastic ocular flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small-cell lung cancer. Journal of Neurology, Neurosurgery and Psychiatry, 82(3), 344-346. [More Information]

2010

  • Kumar, K., Ng, K., Vandebona, H., Davis, M., Sue, C. (2010). A novel CLCN1 mutation (G1652A) causing a mild phenotype of Thomsen disease. Muscle and Nerve, 41(3), 412-415. [More Information]
  • Chan, Q., Ng, K., Vandervord, J. (2010). Critical illness polyneuropathy in patients with major burn injuries. Eplasty: open access journal of plastic surgery committer to the free exchange of knowledge in a global community, 10, 568-574. [More Information]
  • Kumar, K., Ng, K. (2010). Don't hold your breath: anoxic convulsions from coupled hyperventilation-underwater breath-holding. Medical Journal of Australia, 192(11), 663-664. [More Information]
  • Rejdak, K., Petzold, A., Ng, K., Afra, J., Dujmovic, I., Stelmasiak, Z., Ryglewicz, D., Kwiecinski, H., Grisold, W., Vecsei, L., et al (2010). Neurology training around the world: asking the trainees. Lancet Neurology, 9(1), 32-3. [More Information]
  • Ng, K., Winter, S., Sue, C., Burke, D. (2010). Preserved motor axonal membrane potential in mitochondrial disease. Journal of Neurology, Neurosurgery and Psychiatry, 81(8), 844-846. [More Information]
  • Kumar, K., Ng, K. (2010). Reduced facial nerve hyperexcitability from contralateral cerebral stroke in hemifacial spasm. Movement Disorders, 25(9), 1310-2. [More Information]
  • Kumar, K., Needham, M., Mina, K., Davis, M., Brewer, J., Staples, C., Ng, K., Sue, C., Mastaglia, F. (2010). Two Australian families with inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia: novel clinical and genetic findings. Neuromuscular Disorders, 20(5), 330-334. [More Information]

2009

  • Leong, G., Gorrie, C., Ng, K., Rutkowski, S., Waite, P. (2009). Electrical perceptual threshold testing: a validation study. Journal of Spinal Cord Medicine, 32(2), 140-146. [More Information]

2008

  • Ng, K., Howells, J., Pollard, J., Burke, D. (2008). Up-regulation of slow K+ channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosis. Brain, 131(11), 3062-3071. [More Information]

2007

  • Ng, K., Lin, C., Murray, N., Burroughs, A., Bostock, H. (2007). Conduction and excitability properties of peripheral nerves in end-stage liver disease. Muscle and Nerve, 35(6), 730-738. [More Information]
  • Ng, K., Burke, D. (2007). Nerve Excitability Studies in the Present Era. Advances in Clinical Neuroscience & Rehabilitation, 7(5), 29-30.
  • Gunja, N., Dowsett, R., Ng, K. (2007). Raw salmon or red herring: ascending paralysis with suspected seafood poisoning. Medical Journal of Australia, 187(8), 468-469. [More Information]
  • Ng, K., Jones, S. (2007). The ‘‘enhanced N35’’ somatosensory evoked potential: its associations and potential utility in the clinical evaluation of dystonia and myoclonus. Journal of Neurology, 254(1), 46-52. [More Information]

2003

  • Spratt, N., Wang, Y., Levi, C., Ng, K., Evans, M., Fisher, J. (2003). A prospective study of predictors of prolonged hospital stay and disability after stroke. Journal of Clinical Neuroscience, 10(6), 665-669. [More Information]

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