Dr Kate Quinlan

NHMRC Overseas-Based Biomedical Fellowship
Paediatrics & Child Health, Children's Hospital, Westmead
Institute of Neuromuscular Research

Telephone +61 2 9845 1441
Fax +61 2 9845 3078

Map

Selected grants

2014

  • The effects of α-actinin-3 on muscle metabolism, human health and disease; North K, Bishop D, Head S, Quinlan (nee Edwards) K; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Molecular dissection of the functional regions of ACTN2 and ACTN3 and their contribution to normal variation in skeletal muscle function; Robinson P, North K, Quinlan (nee Edwards) K; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • The role of growth factors in pluripotency and differentiation of human embryonic stem cells - towards human therapy; Quinlan (nee Edwards) K; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Journals

  • Garton, F., Seto, J., Quinlan (nee Edwards), K., Yang, N., Houweling, P., North, K. (2014). alpha-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilisation. Human Molecular Genetics, 23(7), 1879-1893. [More Information]
  • Thomas, K., Zheng, X., Garces Suarez, F., Raftery, J., Quinlan (nee Edwards), K., Yang, N., North, K., Houweling, P. (2014). Evidence based selection of commonly used RT-qPCR reference genes for the analysis of mouse skeletal muscle. PLoS One, 9(2), e88653- 1-e88653- 11. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Seto, J., Quinlan (nee Edwards), K., Lek, M., Zheng, X., Garton, F., MacArthur, D., Hogarth, M., Houweling, P., Gregorevic, P., Turner, N., Yang, N., North, K., et al (2013). ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling. Journal of Clinical Investigation, 123(10), 4255-4263. [More Information]
  • Seto, J., Lek, M., Quinlan (nee Edwards), K., Houweling, P., Zheng, X., Garton, F., Macarthur, D., Raftery, J., Garvey, S., Hauser, M., North, K., et al (2011). Deficiency of a-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. Human Molecular Genetics. [More Information]
  • Seto, J., Chan, S., Turner, N., MacArthur, D., Raftery, J., Berman, Y., Quinlan (nee Edwards), K., Cooney, G., Head, S., Yang, N., North, K. (2011). The effect of α-actinin-3 deficiency on muscle aging. Experimental Gerontology, 46(4), 292-302. [More Information]
  • Nunez Martin, N., Clifton, M., Funnell, A., Crisbel, A., Hallal, S., Quinlan (nee Edwards), K., Font Sadurni, J., Vandevenne, M., Setiyaputra, S., Pearson, R., Mackay, J., Crossley, P. (2011). The Multi-zinc Finger Protein ZNF217 Contacts DNA through a Two-finger Domain. Journal of Biological Chemistry, 286(44), 38190-38201. [More Information]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]
  • Quinlan (nee Edwards), K., Seto, J., Turner, N., Vandebrouck, A., Floetenmeyer, M., Macarthur, D., Raftery, J., Lek, M., Yang, N., Parton, R., North, K., et al (2010). Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle. Human Molecular Genetics, 19(7), 1335-1346. [More Information]
  • Lek, M., Quinlan (nee Edwards), K., North, K. (2010). The evolution of skeletal muscle performance: gene duplication and divergence of human sarcomeric alpha-actinins. BioEssays, 32(1), 17-25. [More Information]
  • MacArthur, D., Seto, J., Chan, S., Quinlan (nee Edwards), K., Raftery, J., Turner, N., Nicholson, M., Kee, A., Hardeman, E., Gunning, P., North, K., et al (2008). An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance. Human Molecular Genetics, 17(8), 1076-1086. [More Information]
  • Quinlan (nee Edwards), K., Verger, A., Yaswen, P., Crossley, P. (2007). Amplification of zinc finger gene 217 (ZNF217) and cancer: When good fingers go bad. BBA - Bioenergetics, 1775 (2), 333-340. [More Information]
  • MacArthur, D., Seto, J., Raftery, J., Quinlan (nee Edwards), K., Huttley, G., Hook, J., Lemckert, F., Kee, A., Edwards, M., Berman, Y., Hardeman, E., Gunning, P., Yang, N., North, K., et al (2007). Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nature Genetics, 39(10), 1261-1265. [More Information]
  • Stankovic-Valentin, N., Verger, A., Deltour-Balerdi, S., Quinlan (nee Edwards), K., Crossley, P., Leprince, D. (2006). A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. The FEBS Journal, 273(13), 2879-2890. [More Information]
  • Van Vliet, J., Crofts, L., Quinlan (nee Edwards), K., Czolij, R., Perkins, A., Crossley, P. (2006). Human KLF17 is a new member of the Sp/KLF family of transcription factors. Genomics, 87(4), 474-482. [More Information]
  • Verger, A., Quinlan (nee Edwards), K., Crofts, L., Spano, S., Corda, D., Kable, E., Braet, F., Crossley, P. (2006). Mechanisms Directing the Nuclear Localization of the CtBP Family Proteins. Molecular and Cellular Biology, 26(13), 4882-4894. [More Information]
  • Quinlan (nee Edwards), K., Verger, A., Kwok, A., Lee, S., Perdomo, J., Nardini, M., Bolognesi, M., Crossley, P. (2006). Role of the C-Terminal Binding Protein PXDLS Motif Binding Cleft in Protein Interactions and Transcriptional Repression. Molecular and Cellular Biology, 26(21), 8202-8213. [More Information]
  • Quinlan (nee Edwards), K., Nardini, M., Verger, A., Francescato, P., Yaswen, P., Corda, D., Bolognesi, M., Crossley, P. (2006). Specific Recognition of ZNF217 and Other Zinc Finger Proteins at a Surface Groove of C-Terminal Binding Proteins. Molecular and Cellular Biology, 26(21), 8159-8172. [More Information]
  • Haigh, C., Quinlan (nee Edwards), K., Brown, D. (2005). Copper binding is the governing determinant of prion protein turnover. Molecular and Cellular Neuroscience, 30(2), 186-196. [More Information]

Conferences

  • Seto, J., MacArthur, D., Chan, S., Quinlan (nee Edwards), K., Cooney, G., Head, S., Yang, N., North, K. (2008). Metabolic and physiological changes in Actn3 deficient mice: defining the association between alpha -actinin-3 and human athletic performance. New Directions in Biology and Disease of Skeletal Muscle, The Westin at Canal Place: The Westin at Canal Place.

2014

  • Garton, F., Seto, J., Quinlan (nee Edwards), K., Yang, N., Houweling, P., North, K. (2014). alpha-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilisation. Human Molecular Genetics, 23(7), 1879-1893. [More Information]
  • Thomas, K., Zheng, X., Garces Suarez, F., Raftery, J., Quinlan (nee Edwards), K., Yang, N., North, K., Houweling, P. (2014). Evidence based selection of commonly used RT-qPCR reference genes for the analysis of mouse skeletal muscle. PLoS One, 9(2), e88653- 1-e88653- 11. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]

2013

  • Seto, J., Quinlan (nee Edwards), K., Lek, M., Zheng, X., Garton, F., MacArthur, D., Hogarth, M., Houweling, P., Gregorevic, P., Turner, N., Yang, N., North, K., et al (2013). ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling. Journal of Clinical Investigation, 123(10), 4255-4263. [More Information]

2011

  • Seto, J., Lek, M., Quinlan (nee Edwards), K., Houweling, P., Zheng, X., Garton, F., Macarthur, D., Raftery, J., Garvey, S., Hauser, M., North, K., et al (2011). Deficiency of a-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. Human Molecular Genetics. [More Information]
  • Seto, J., Chan, S., Turner, N., MacArthur, D., Raftery, J., Berman, Y., Quinlan (nee Edwards), K., Cooney, G., Head, S., Yang, N., North, K. (2011). The effect of α-actinin-3 deficiency on muscle aging. Experimental Gerontology, 46(4), 292-302. [More Information]
  • Nunez Martin, N., Clifton, M., Funnell, A., Crisbel, A., Hallal, S., Quinlan (nee Edwards), K., Font Sadurni, J., Vandevenne, M., Setiyaputra, S., Pearson, R., Mackay, J., Crossley, P. (2011). The Multi-zinc Finger Protein ZNF217 Contacts DNA through a Two-finger Domain. Journal of Biological Chemistry, 286(44), 38190-38201. [More Information]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]

2010

  • Quinlan (nee Edwards), K., Seto, J., Turner, N., Vandebrouck, A., Floetenmeyer, M., Macarthur, D., Raftery, J., Lek, M., Yang, N., Parton, R., North, K., et al (2010). Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle. Human Molecular Genetics, 19(7), 1335-1346. [More Information]
  • Lek, M., Quinlan (nee Edwards), K., North, K. (2010). The evolution of skeletal muscle performance: gene duplication and divergence of human sarcomeric alpha-actinins. BioEssays, 32(1), 17-25. [More Information]

2008

  • MacArthur, D., Seto, J., Chan, S., Quinlan (nee Edwards), K., Raftery, J., Turner, N., Nicholson, M., Kee, A., Hardeman, E., Gunning, P., North, K., et al (2008). An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance. Human Molecular Genetics, 17(8), 1076-1086. [More Information]
  • Seto, J., MacArthur, D., Chan, S., Quinlan (nee Edwards), K., Cooney, G., Head, S., Yang, N., North, K. (2008). Metabolic and physiological changes in Actn3 deficient mice: defining the association between alpha -actinin-3 and human athletic performance. New Directions in Biology and Disease of Skeletal Muscle, The Westin at Canal Place: The Westin at Canal Place.

2007

  • Quinlan (nee Edwards), K., Verger, A., Yaswen, P., Crossley, P. (2007). Amplification of zinc finger gene 217 (ZNF217) and cancer: When good fingers go bad. BBA - Bioenergetics, 1775 (2), 333-340. [More Information]
  • MacArthur, D., Seto, J., Raftery, J., Quinlan (nee Edwards), K., Huttley, G., Hook, J., Lemckert, F., Kee, A., Edwards, M., Berman, Y., Hardeman, E., Gunning, P., Yang, N., North, K., et al (2007). Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nature Genetics, 39(10), 1261-1265. [More Information]

2006

  • Stankovic-Valentin, N., Verger, A., Deltour-Balerdi, S., Quinlan (nee Edwards), K., Crossley, P., Leprince, D. (2006). A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. The FEBS Journal, 273(13), 2879-2890. [More Information]
  • Van Vliet, J., Crofts, L., Quinlan (nee Edwards), K., Czolij, R., Perkins, A., Crossley, P. (2006). Human KLF17 is a new member of the Sp/KLF family of transcription factors. Genomics, 87(4), 474-482. [More Information]
  • Verger, A., Quinlan (nee Edwards), K., Crofts, L., Spano, S., Corda, D., Kable, E., Braet, F., Crossley, P. (2006). Mechanisms Directing the Nuclear Localization of the CtBP Family Proteins. Molecular and Cellular Biology, 26(13), 4882-4894. [More Information]
  • Quinlan (nee Edwards), K., Verger, A., Kwok, A., Lee, S., Perdomo, J., Nardini, M., Bolognesi, M., Crossley, P. (2006). Role of the C-Terminal Binding Protein PXDLS Motif Binding Cleft in Protein Interactions and Transcriptional Repression. Molecular and Cellular Biology, 26(21), 8202-8213. [More Information]
  • Quinlan (nee Edwards), K., Nardini, M., Verger, A., Francescato, P., Yaswen, P., Corda, D., Bolognesi, M., Crossley, P. (2006). Specific Recognition of ZNF217 and Other Zinc Finger Proteins at a Surface Groove of C-Terminal Binding Proteins. Molecular and Cellular Biology, 26(21), 8159-8172. [More Information]

2005

  • Haigh, C., Quinlan (nee Edwards), K., Brown, D. (2005). Copper binding is the governing determinant of prion protein turnover. Molecular and Cellular Neuroscience, 30(2), 186-196. [More Information]

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