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Associate Professor Kate Wyburn

Clinical Associate Professor
Medicine, Central Clinical School

Member of the Charles Perkins Centre

Telephone 9515 6600

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Biographical details

A/Prof Kate Wyburn is a Senior Staff SpecialistNephrologist and Transplant Physician at Royal Prince Alfred Hospital, Sydney and a Clinical A/Professor at the Faculty of Medicine, Central Clinical School, University of Sydney. She has a long-standing interest in immunology and its relationship to renal disease, and undertook a PhD in Transplant Immunology at The University of Sydney.
A/Prof Kate Wyburn is the current Chair of the NSW Transplant Advisory Committee and a member of the national Renal Transplant Advisory Committee. She is involved in NSW donor medical suitability assessment programs and review committees. Her main clinical and research interests include highly sensitised kidney transplantation, both HLA and ABO incompatible and B cell immunobiology.
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Current research students

Project title Research student
Identifying opportunities to increase organ donation rates in New South Wales Imogen THOMSON
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Selected grants

2016

  • Safety and Biovigilance in Organ Donation in NSW, Australia (SAFE-BOD study); Webster A, Wyburn K; NSW Health./Research Project Support.
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Selected publications

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Journals

  • Vincenti, F., Budde, K., Merville, P., Shihab, F., Peddi, V., Shah, M., Wyburn, K., Cassuto-Viguier, E., Weidemann, A., Lee, M., et al (2018). A randomized, phase 2 study of ASP0113, a DNA-based vaccine, for the prevention of CMV in CMV-seronegative kidney transplant recipients receiving a kidney from a CMV-seropositive donor. American Journal Of Transplantation, 18(12), 2945-2954. [More Information]
  • Agarwal, N., Davis, R., Gracey, D., Wong, G., Kable, K., Wong, J., Nankivell, B., Strasser, S., Wyburn, K. (2018). Detection of Hepatitis C antibodies without viral transmission in Hepatitis C negative recipients receiving kidneys from Hepatitis C positive donors treated with Direct Acting Anti-Viral Therapy. Transplantation, 102(3), e121-e122. [More Information]
  • Tangirala, N., Singer, J., Snelling, P., Wyburn, K., Chadban, S., Aouad, L., Gracey, D. (2018). Emphysematous pyelonpehritis in a dual kidney transplant recipient. Nephrology, 23(11), 1064-1065. [More Information]
  • Aouad, L., Clayton, P., Wyburn, K., Gracey, D., Chadban, S. (2018). EVOLUTION OF GLYCAEMIC CONTROL AND VARIABILITY AFTER KIDNEY TRANSPLANT. Transplantation, 102(9), 1563-1568. [More Information]
  • Waller, K., Wyburn, K., Shackel, N., O'Leary, M., Kelly, P., Webster, A. (2018). Hepatitis transmission risk in kidney transplantation (the HINT study): a cross-sectional survey of transplant clinicians in Australian and New Zealand. Transplantation, 102(1), 146-153. [More Information]
  • Jayasinghe, K., Haber, A., Wyburn, K., Gracey, D., Chadban, S. (2018). Recurrent oxalosis in a combined liver-kidney transplant patient with primary hyperoxaluria type 1 resulting in graft failure. Nephrology, 23(10), 962-964. [More Information]
  • Vaishnav, C., Craig, J., Howard, K., Howell, M., Alexander, S., Chadban, S., Clayton, P., Lim, W., Kanellis, J., Wyburn, K., Yang, J., Wong, G., et al (2018). Survival and quality of life impact of a risk-based allocation algorithm for deceased donor kidney transplantation. Transplantation, 102(9), 1530-1537. [More Information]
  • Wan, S., Ying, T., Wyburn, K., Roberts, D., Wyld, M., Chadban, S. (2018). The treatment of antibody-mediated rejection in kidney transplantation: An updated systematic review and meta-analysis. Transplantation, 102(4), 557-568. [More Information]
  • Lo, P., Sharma, A., Craig, J., Wyburn, K., Lim, W., Chapman, J., Palmer, S., Strippoli, G., Wong, G. (2016). Preconditioning Therapy in ABO-Incompatible Living Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation, 100(4), 933-942. [More Information]
  • Clayton, P., Aouad, L., Wyburn, K., Eris, J., Chadban, S. (2015). HbA1c Is Insensitive at Month 3 After Kidney Transplantation. Transplantation, 99(5), e37-e38. [More Information]
  • Sud, R., Garry, L., Spicer, S., Allen, R., Eris, J., Wyburn, K., Verran, D., Cooper, C., Chadban, S. (2014). A role for everolimus in post-transplant encapsulating peritoneal sclerosis: First case report. Nephrology, 19(SUPPL. 1), 27-30. [More Information]
  • Wyburn, K., Chadban, S., Kwan, T., Alexander, S., Wu, H. (2013). Interleukin-18 binding protein therapy is protective in adriamycin nephropathy. AJP: Renal Physiology (Online), 304(1), F68-F76. [More Information]
  • Ko, H., Yin, J., Wyburn, K., Wu, H., Eris, J., Hambly, B., Chadban, S. (2013). Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunction. Nephrology Dialysis Transplantation, 28(2), 327-336. [More Information]
  • Wang, Y., Sebaratnam, D., Wong, J., Cooper, W., Wyburn, K., Eris, J. (2012). Urethral Stricture Caused by Schistosomiasis in a Renal Transplant Recipient. Nephrology, 17(2), 197-198. [More Information]
  • Wu, H., Ma, J., Wang, P., Corpuz, T., Panchapakesan, U., Wyburn, K., Chadban, S. (2010). HMGB1 Contributes to Kidney Ischemia Reperfusion Injury. Journal of the American Society of Nephrology, 21(11), 1878-1890. [More Information]
  • Hardy, J., Hambly, B., Ko, H., Wyburn, K., Eris, J., Yin, J. (2010). Stimulation of Mesangial Cells by Angiotensin II and Lipopolysaccharide Increases Expression of Interleukin-18, but Not IL-18 Receptor. Nephron Journals, 116(4), e63-e71. [More Information]
  • Jardine, M., Bhandari, S., Wyburn, K., Misra, A., McKenzie, P., Eris, J. (2009). Photopheresis therapy for problematic renal allograft rejection. Journal of Clinical Apheresis, 24(4), 161-169. [More Information]
  • Ko, H., Hambly, B., Eris, J., Levidiotis, V., Wyburn, K., Wu, H., Chadban, S., Yin, J. (2008). Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A. Transplant Immunology, 20(1-2), 99-105. [More Information]
  • Wu, H., Craft, M., Wang, P., Wyburn, K., Chen, G., Ma, J., Hambly, B., Chadban, S. (2008). IL-18 Contributes to Renal Damage after Ischemia-Reperfusion. Journal of the American Society of Nephrology, 19(12), 2331-2341. [More Information]
  • Jefferys, A., Wyburn, K., Chow, J., Cleland, B., Hennessy, A. (2008). Peritoneal dialysis in pregnancy: a case series. Nephrology, 13(5), 380-383. [More Information]
  • Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]
  • Wyburn, K., Wu, H., Chen, G., Yin, J., Eris, J., Chadban, S. (2006). Interleukin-18 affects local cytokine expression but does not impact on the development of kidney allograft rejection. American Journal Of Transplantation, 6(11), 2612-2621. [More Information]
  • Wyburn, K., Wu, H., Yin, J., Jose, M., Eris, J., Chadban, S. (2005). Macrophage-derived interleukin-18 in experimental renal allograft rejection. Nephrology, Dialysis, Transplantation, 20(4), 699-706. [More Information]
  • Wyburn, K., Jose, M., Wu, H., Atkins, R., Chadban, S. (2005). The Role of Macrophages in Allograft Rejection. Transplantation, 80(12), 1641-1647. [More Information]
  • Wyburn, K., Horvath, J. (2003). Chronic renal insufficiency and renoprotective strategies. Internal Medicine Journal, 33(5-6), 237-241. [More Information]

Conferences

  • Ko, H., Yin, J., Hambly, B., Wyburn, K., Wu, H., Chadban, S., Eris, J. (2006). Rapamycin and Sanglifehrin A can inhibit interleukin-18 production from dendritic cells in vitro and in vivo. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Yin, J., Ko, H., Wyburn, K., Wu, H., Hambly, B., Chadban, S., Eris, J. (2006). The role of IL-12 family cytokines in chronic allograft nephropathy. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wu, H., Chen, G., Wyburn, K., Afifi, M., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2006). TLR4 activation mediates kidney ischemia reperfusion injury. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Ko, H., Yin, J., Hambly, B., Wyburn, K., Wu, H., Chadban, S., Eris, J. (2005). Immunosuppressants rapamycin and sanglifehrin A inhibit bioactive IL-18 production by dendritic. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.
  • Wyburn, K., Wu, H., Yin, J., Jose, M., Eris, J., Chadban, S. (2005). Interleukin-18 is elevated in experimental renal allograft rejection. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Yin, J., Wyburn, K., Wu, H., Chadban, S., Eris, J. (2005). The role of IL-18 and IL-12 family in chronic allograft nephropathy. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and it''s ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and its ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.

2018

  • Vincenti, F., Budde, K., Merville, P., Shihab, F., Peddi, V., Shah, M., Wyburn, K., Cassuto-Viguier, E., Weidemann, A., Lee, M., et al (2018). A randomized, phase 2 study of ASP0113, a DNA-based vaccine, for the prevention of CMV in CMV-seronegative kidney transplant recipients receiving a kidney from a CMV-seropositive donor. American Journal Of Transplantation, 18(12), 2945-2954. [More Information]
  • Agarwal, N., Davis, R., Gracey, D., Wong, G., Kable, K., Wong, J., Nankivell, B., Strasser, S., Wyburn, K. (2018). Detection of Hepatitis C antibodies without viral transmission in Hepatitis C negative recipients receiving kidneys from Hepatitis C positive donors treated with Direct Acting Anti-Viral Therapy. Transplantation, 102(3), e121-e122. [More Information]
  • Tangirala, N., Singer, J., Snelling, P., Wyburn, K., Chadban, S., Aouad, L., Gracey, D. (2018). Emphysematous pyelonpehritis in a dual kidney transplant recipient. Nephrology, 23(11), 1064-1065. [More Information]
  • Aouad, L., Clayton, P., Wyburn, K., Gracey, D., Chadban, S. (2018). EVOLUTION OF GLYCAEMIC CONTROL AND VARIABILITY AFTER KIDNEY TRANSPLANT. Transplantation, 102(9), 1563-1568. [More Information]
  • Waller, K., Wyburn, K., Shackel, N., O'Leary, M., Kelly, P., Webster, A. (2018). Hepatitis transmission risk in kidney transplantation (the HINT study): a cross-sectional survey of transplant clinicians in Australian and New Zealand. Transplantation, 102(1), 146-153. [More Information]
  • Jayasinghe, K., Haber, A., Wyburn, K., Gracey, D., Chadban, S. (2018). Recurrent oxalosis in a combined liver-kidney transplant patient with primary hyperoxaluria type 1 resulting in graft failure. Nephrology, 23(10), 962-964. [More Information]
  • Vaishnav, C., Craig, J., Howard, K., Howell, M., Alexander, S., Chadban, S., Clayton, P., Lim, W., Kanellis, J., Wyburn, K., Yang, J., Wong, G., et al (2018). Survival and quality of life impact of a risk-based allocation algorithm for deceased donor kidney transplantation. Transplantation, 102(9), 1530-1537. [More Information]
  • Wan, S., Ying, T., Wyburn, K., Roberts, D., Wyld, M., Chadban, S. (2018). The treatment of antibody-mediated rejection in kidney transplantation: An updated systematic review and meta-analysis. Transplantation, 102(4), 557-568. [More Information]

2016

  • Lo, P., Sharma, A., Craig, J., Wyburn, K., Lim, W., Chapman, J., Palmer, S., Strippoli, G., Wong, G. (2016). Preconditioning Therapy in ABO-Incompatible Living Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation, 100(4), 933-942. [More Information]

2015

  • Clayton, P., Aouad, L., Wyburn, K., Eris, J., Chadban, S. (2015). HbA1c Is Insensitive at Month 3 After Kidney Transplantation. Transplantation, 99(5), e37-e38. [More Information]

2014

  • Sud, R., Garry, L., Spicer, S., Allen, R., Eris, J., Wyburn, K., Verran, D., Cooper, C., Chadban, S. (2014). A role for everolimus in post-transplant encapsulating peritoneal sclerosis: First case report. Nephrology, 19(SUPPL. 1), 27-30. [More Information]

2013

  • Wyburn, K., Chadban, S., Kwan, T., Alexander, S., Wu, H. (2013). Interleukin-18 binding protein therapy is protective in adriamycin nephropathy. AJP: Renal Physiology (Online), 304(1), F68-F76. [More Information]
  • Ko, H., Yin, J., Wyburn, K., Wu, H., Eris, J., Hambly, B., Chadban, S. (2013). Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunction. Nephrology Dialysis Transplantation, 28(2), 327-336. [More Information]

2012

  • Wang, Y., Sebaratnam, D., Wong, J., Cooper, W., Wyburn, K., Eris, J. (2012). Urethral Stricture Caused by Schistosomiasis in a Renal Transplant Recipient. Nephrology, 17(2), 197-198. [More Information]

2010

  • Wu, H., Ma, J., Wang, P., Corpuz, T., Panchapakesan, U., Wyburn, K., Chadban, S. (2010). HMGB1 Contributes to Kidney Ischemia Reperfusion Injury. Journal of the American Society of Nephrology, 21(11), 1878-1890. [More Information]
  • Hardy, J., Hambly, B., Ko, H., Wyburn, K., Eris, J., Yin, J. (2010). Stimulation of Mesangial Cells by Angiotensin II and Lipopolysaccharide Increases Expression of Interleukin-18, but Not IL-18 Receptor. Nephron Journals, 116(4), e63-e71. [More Information]

2009

  • Jardine, M., Bhandari, S., Wyburn, K., Misra, A., McKenzie, P., Eris, J. (2009). Photopheresis therapy for problematic renal allograft rejection. Journal of Clinical Apheresis, 24(4), 161-169. [More Information]

2008

  • Ko, H., Hambly, B., Eris, J., Levidiotis, V., Wyburn, K., Wu, H., Chadban, S., Yin, J. (2008). Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A. Transplant Immunology, 20(1-2), 99-105. [More Information]
  • Wu, H., Craft, M., Wang, P., Wyburn, K., Chen, G., Ma, J., Hambly, B., Chadban, S. (2008). IL-18 Contributes to Renal Damage after Ischemia-Reperfusion. Journal of the American Society of Nephrology, 19(12), 2331-2341. [More Information]
  • Jefferys, A., Wyburn, K., Chow, J., Cleland, B., Hennessy, A. (2008). Peritoneal dialysis in pregnancy: a case series. Nephrology, 13(5), 380-383. [More Information]

2007

  • Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]

2006

  • Wyburn, K., Wu, H., Chen, G., Yin, J., Eris, J., Chadban, S. (2006). Interleukin-18 affects local cytokine expression but does not impact on the development of kidney allograft rejection. American Journal Of Transplantation, 6(11), 2612-2621. [More Information]
  • Ko, H., Yin, J., Hambly, B., Wyburn, K., Wu, H., Chadban, S., Eris, J. (2006). Rapamycin and Sanglifehrin A can inhibit interleukin-18 production from dendritic cells in vitro and in vivo. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Yin, J., Ko, H., Wyburn, K., Wu, H., Hambly, B., Chadban, S., Eris, J. (2006). The role of IL-12 family cytokines in chronic allograft nephropathy. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wu, H., Chen, G., Wyburn, K., Afifi, M., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2006). TLR4 activation mediates kidney ischemia reperfusion injury. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.

2005

  • Ko, H., Yin, J., Hambly, B., Wyburn, K., Wu, H., Chadban, S., Eris, J. (2005). Immunosuppressants rapamycin and sanglifehrin A inhibit bioactive IL-18 production by dendritic. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.
  • Wyburn, K., Wu, H., Yin, J., Jose, M., Eris, J., Chadban, S. (2005). Interleukin-18 is elevated in experimental renal allograft rejection. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Wyburn, K., Wu, H., Yin, J., Jose, M., Eris, J., Chadban, S. (2005). Macrophage-derived interleukin-18 in experimental renal allograft rejection. Nephrology, Dialysis, Transplantation, 20(4), 699-706. [More Information]
  • Yin, J., Wyburn, K., Wu, H., Chadban, S., Eris, J. (2005). The role of IL-18 and IL-12 family in chronic allograft nephropathy. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.
  • Wyburn, K., Jose, M., Wu, H., Atkins, R., Chadban, S. (2005). The Role of Macrophages in Allograft Rejection. Transplantation, 80(12), 1641-1647. [More Information]
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and it''s ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and its ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.

2003

  • Wyburn, K., Horvath, J. (2003). Chronic renal insufficiency and renoprotective strategies. Internal Medicine Journal, 33(5-6), 237-241. [More Information]
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