Associate Professor Kay Double

Associate Professor
Biomedical Sciences, School of Medical Sciences

Telephone +61 2 9351 9357

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Selected grants

2014

  • Potential of ionophore therapy for neuroprotection in Parkinson's disease; Double K, Finkelstein D; Parkinson's New South Wales Incorporated/Research Grants.
  • Agents targeting iron in the brain in Parkinson's disease; Codd R, Double K, Liddell J, Witting P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Does rigidity in Parkinson’s disease change the passive mechanical properties of muscle?; Diong J, Double K; University of Sydney/Internal Research Grant Allocations.
  • Restoring brain copper in a murine model of copper deficiency; Double K, Finkelstein D; University of Sydney/Internal Research Grant Allocations.

2013

  • A role for the Parkinson proteins α-synuclein and LRRK2 in altered brain cell birth in a Parkinson's disease; Double K; Parkinson's New South Wales Incorporated/Research Support.

2012

  • Human tyrosine hydroxylase isoforms and susceptibility of dopaminergic neurons to degeneration in Parkinsons's disease; Dickson P, Dunkley P, Double K; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Molecular mechanism of testosterone action on midbrain dopamine neuron differentiation; Shannon Weickert C, Double K; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Copper pathways are altered in Parkinson's disease: Implications for cell vulnerability; Double K, Finkelstein D, Mercer J; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Synchrotron microprobe analysis of copper changes in murine models of neurodegenerative disease; Double K; International Sciences Linkages Programme/French-Australian Science and Technology Programme.

Selected publications

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Edited Books

  • Gerlach, M., Deckert, J., Double, K., Koutsilieri, E. (2007). Neuropyschiatric disorders: an integrative approach. J. Neural Trans. Suppl 72. New York: Springer.

Book Chapters

  • Double, K., Finberg, J. (2013). Neuroscience in the 21st Century: From Basic to Clinical. In D Pfaff (Eds.), Neuroscience in the 21st Century: From Basic to Clinical, (pp. 2903-2922). New York: Springer.
  • Double, K., Finberg, J. (2012). Parkinson’s disease. In D Pfaff (Eds.), Neuroscience in the 21st Century: From Basic to Clinical, (pp. 2902-2921). New York: Springer.
  • Halliday, G., Reyes, S., Double, K. (2012). Substantia Nigra, Ventral Tegmental Area, and Retrorubral Fields. In Juergen K. Mai & George Paxinos (Eds.), The Human Nervous System, 3rd Edition, (pp. 439-455). London: Academic Press.
  • Double, K., Maruyama, W., Naoi, M., Gerlach, M., Riederer, P. (2011). Biological Role of Neuromelanin in the Human Brain and Its Importance in Parkinson's Disease. In Jan Borovansky and Patrick A. Riley (Eds.), Melanins and Melanosomes: Biosynthesis, Biogenesis, Physiological, and Pathological Functions, (pp. 225-246). Weinheim: Wiley-V C H Verlag Gmbh.
  • Double, K., Halliday, G., Reyes, S. (2011). Substantia Nigra, Ventral Tegmental Area and Retrorubral Fields. In Juergen K. Mai & George Paxinos (Eds.), The Human Nervous System, 3rd Edition, (pp. 439-455). London: Academic Press.

Journals

  • Double, K., Davies, K., Bohic, S., Carmona, A., Ortega, R., Cottam, V., Hare, D., Finberg, J., Reyes, S., Halliday, G., et al (2014). Copper pathology in vulnerable brain regions in Parkinson’s disease. Neurobiology of Aging, 35(4), 858-866. [More Information]
  • Dang, T., Dobson-Stone, C., Glaros, E., Kim, W., Hallupp, M., Bartley, L., Piguet, O., Hodges, J., Halliday, G., Double, K., et al (2013). Endogenous progesterone levels and frontotemporal dementia: Modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model. Disease Models and Mechanisms, 6(5), 1198-1204. [More Information]
  • Davies, K., Hare, D., Cottam, V., Chen, N., Hilgers, L., Halliday, G., Mercer, J., Double, K. (2013). Localization of copper and copper transporters in the human brain. Metallomics, 5(1), 43-51. [More Information]
  • Reyes, S., Fu, Y., Double, K., Cottam, V., Thompson, L., Kirik, D., Paxinos, G., Watson, C., Cooper, H., Halliday, G. (2013). Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. Neurobiology of Aging, 34(3), 873-886. [More Information]
  • Reyes, S., Cottam, V., Kirik, D., Double, K., Halliday, G. (2013). Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Movement Disorders, 28(10), 1351-1359. [More Information]
  • Reyes, S., Fu, Y., Double, K., Thompson, L., Kirik, D., Paxinos, G., Halliday, G. (2012). GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area. The Journal of Comparative Neurology, 520(12), 2591-2607. [More Information]
  • Chan, S., Dunlop, R., Rowe, A., Double, K., Rodgers, K. (2012). L-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitro. Experimental Neurology, 238(1), 29-37. [More Information]
  • Double, K. (2012). Neuronal vulnerability in Parkinson’s disease. Parkinsonism and Related Disorders, 18(Suppl 1), S52-S54. [More Information]
  • Purves-Tyson, T., Handelsman, D., Double, K., Owens, S., Bustamante, S., Weickert, C. (2012). Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra. BMC Neuroscience, 13(1), 1-12. [More Information]
  • Kurz, A., Double, K., Lastres-Becker, I., Tozzi, A., Tantucci, M., Bockhart, V., Bonin, M., Garcia-Arencibia, M., Nuber, S., Schlaudraff, F. (2010). A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS One, 5(7), 1-15. [More Information]
  • Werry, E., Enjeti, S., Halliday, G., Sachdev, P., Double, K. (2010). Effect of age on proliferation-regulating factors in human adult neurogenic areas. Journal of Neurochemistry, 115(4), 956-964. [More Information]
  • Schofield, E., Halliday, G., Kwok, J., Loy, C., Double, K., Hodges, J. (2010). Low Serum Progranulin Predicts the Presence of Mutations: A Prospective Study. Journal of Alzheimer's Disease, 22(3), 981-984. [More Information]
  • Double, K., Todd, G., Duma, S. (2010). Pathophysiology of transcranial sonography signal changes in the human substantia nigra. International Review of Neurobiology, 90(C), 107-120. [More Information]
  • Double, K., Halliday, G., Dunkley, P., Dickson, P., Gerlach, M., Riederer, P. (2010). Pigmentation in the human brain and risk of Parkinson's disease. Annals of Neurology, 67(4), 553-554. [More Information]
  • Double, K., Reyes, S., Werry, E., Halliday, G. (2010). Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions? Progress in Neurobiology, 92(3), 316-329. [More Information]
  • Double, K., Rowe, D., Carew-Jones, F., Hayes, M., Chan, D., Blackie, J., Corbett, A., Joffe, R., Fung, V., Morris, J., et al (2009). Anti-melanin antibodies are increased in sera in Parkinson's disease. Experimental Neurology, 217, 297-301. [More Information]
  • Piguet, O., Double, K., Kril, J., Harasty, J., Macdonald, V., McRitchie, D., Halliday, G. (2009). White matter loss in healthy ageing: A postmortem analysis. Neurobiology of Aging, 30(8), 1288-1295. [More Information]
  • Sutherland, G., Mellick, G., Newman, J., Double, K., Stevens, J., Lee, L., Rowe, D., Silburn, P., Halliday, G. (2008). Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B (4), 495-499. [More Information]
  • Bohic, S., Murphy, K., Paulus, W., Cloetens, P., Salome, M., Susini, J., Double, K. (2008). Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy. Analytical Chemistry, 80(24), 9557-9566. [More Information]
  • Gerlach, M., Riederer, P., Double, K. (2008). Neuromelanin-bound ferric iron as an experimental model of dopaminergic neurodegeneration in Parkinson's disease. Parkinsonism and Related Disorders, 14(Suppl. 2), S185-S188. [More Information]
  • Double, K., Dedov, V., Fedorow, H., Kettle, E., Halliday, G., Garner, B., Brunk, U. (2008). The comparative biology of neuromelanin and lipofuscin in the human brain. Cellular and Molecular Life Sciences, 65, 1669-1682. [More Information]
  • Gerlach, M., Deckert, J., Double, K., Koutsilieri, E. (2007). Journal of Neural Transmission, Supplementa: Preface. Journal of Neural Transmission, Supplementa, 27, V-VI.
  • Dedov, V., Griffiths, F., Garner, B., Halliday, G., Double, K. (2007). Lipid content determines aggregation of neuromelanin granules in vitro. Journal of Neural Transmission, Supplementa, 72, 35-38. [More Information]
  • Behnke, S., Double, K., Duma, S., Broe, G., Guenther, V., Becker, G., Halliday, G. (2007). Substantia nigra echomorphology in the healthy very old: Correlation with motor slowing. NeuroImage, 34(3), 1054-1059. [More Information]
  • Behnke, S., Double, K., Duma, S., Broe, G., Guenther, V., Becker, G., Halliday, G. (2007). Substantia nigra echomorphology in the healthy very old: Correlation with motor slowing. NeuroImage, 34(3), 1054-1059.
  • Halliday, G., Fedorow, H., Rickert, C., Gerlach, M., Riederer, P., Double, K. (2006). Evidence for specific phases in the development of human neuromelanin. Journal of Neural Transmission, 113, 721-728. [More Information]
  • Fedorow, H., Halliday, G., Rickert, C., Gerlach, M., Riederer, P., Double, K. (2006). Evidence for specific phases in the development of human neuromelanin. Neurobiology of Aging, 27(3), 506-512. [More Information]
  • Fedorow, H., Pickford, R., Kettle, E., Cartwright, M., Halliday, G., Gerlach, M., Riederer, P., Garner, B., Double, K. (2006). Investigation of the lipid component of neuromelanin. Journal of Neural Transmission, 113, 735-739. [More Information]
  • Fedorow, H., Pickford, R., Hook, J., Double, K., Halliday, G., Gerlach, M., Riederer, P., Garner, B. (2005). Dolichol is the major lipid component of human substantia nigra neuromelanin. Journal of Neurochemistry, 92, 990-995. [More Information]
  • Fedorow, H., Tribl, F., Halliday, G., Gerlach, M., Riederer, P., Double, K. (2005). Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson’s disease. Progress in Neurobiology, 75, 109-124. [More Information]
  • Halliday, G., Ophof, A., Broe, M., Jensen, P., Kettle, E., Fedorow, H., Cartwright, M., Griffiths, F., Shepherd, C., Double, K. (2005). α-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease. Brain, 128, 2654-2664.
  • Halliday, G., Double, K., Macdonald, V., Kril, J. (2003). Identifying severely atrophic cortical subregions in Alzheimer's disease. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 24(6), 797-806.
  • Double, K., Rowe, D., Hayes, M., Chan, D., Blackie, J., Corbett, A., Joffe, R., Fung, V., Morris, J., Halliday, G. (2003). Identifying the Pattern of Olfactory Deficits in Parkinson Disease Using the Brief Smell Identification Test. JAMA Neurology, 60(4), 545-549. [More Information]
  • Double, K., Halliday, G., Henderson, J., Griffiths, F., Heinemann, T., Riederer, P., Gerlach, M. (2003). The dopamine receptor agonist lisuride attenuates iron-mediated dopaminergic neurodegeneration. Experimental Neurology, 184(1), 530-535. [More Information]

2014

  • Double, K., Davies, K., Bohic, S., Carmona, A., Ortega, R., Cottam, V., Hare, D., Finberg, J., Reyes, S., Halliday, G., et al (2014). Copper pathology in vulnerable brain regions in Parkinson’s disease. Neurobiology of Aging, 35(4), 858-866. [More Information]

2013

  • Dang, T., Dobson-Stone, C., Glaros, E., Kim, W., Hallupp, M., Bartley, L., Piguet, O., Hodges, J., Halliday, G., Double, K., et al (2013). Endogenous progesterone levels and frontotemporal dementia: Modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model. Disease Models and Mechanisms, 6(5), 1198-1204. [More Information]
  • Davies, K., Hare, D., Cottam, V., Chen, N., Hilgers, L., Halliday, G., Mercer, J., Double, K. (2013). Localization of copper and copper transporters in the human brain. Metallomics, 5(1), 43-51. [More Information]
  • Double, K., Finberg, J. (2013). Neuroscience in the 21st Century: From Basic to Clinical. In D Pfaff (Eds.), Neuroscience in the 21st Century: From Basic to Clinical, (pp. 2903-2922). New York: Springer.
  • Reyes, S., Fu, Y., Double, K., Cottam, V., Thompson, L., Kirik, D., Paxinos, G., Watson, C., Cooper, H., Halliday, G. (2013). Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. Neurobiology of Aging, 34(3), 873-886. [More Information]
  • Reyes, S., Cottam, V., Kirik, D., Double, K., Halliday, G. (2013). Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Movement Disorders, 28(10), 1351-1359. [More Information]

2012

  • Reyes, S., Fu, Y., Double, K., Thompson, L., Kirik, D., Paxinos, G., Halliday, G. (2012). GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area. The Journal of Comparative Neurology, 520(12), 2591-2607. [More Information]
  • Chan, S., Dunlop, R., Rowe, A., Double, K., Rodgers, K. (2012). L-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitro. Experimental Neurology, 238(1), 29-37. [More Information]
  • Double, K. (2012). Neuronal vulnerability in Parkinson’s disease. Parkinsonism and Related Disorders, 18(Suppl 1), S52-S54. [More Information]
  • Double, K., Finberg, J. (2012). Parkinson’s disease. In D Pfaff (Eds.), Neuroscience in the 21st Century: From Basic to Clinical, (pp. 2902-2921). New York: Springer.
  • Halliday, G., Reyes, S., Double, K. (2012). Substantia Nigra, Ventral Tegmental Area, and Retrorubral Fields. In Juergen K. Mai & George Paxinos (Eds.), The Human Nervous System, 3rd Edition, (pp. 439-455). London: Academic Press.
  • Purves-Tyson, T., Handelsman, D., Double, K., Owens, S., Bustamante, S., Weickert, C. (2012). Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra. BMC Neuroscience, 13(1), 1-12. [More Information]

2011

  • Double, K., Maruyama, W., Naoi, M., Gerlach, M., Riederer, P. (2011). Biological Role of Neuromelanin in the Human Brain and Its Importance in Parkinson's Disease. In Jan Borovansky and Patrick A. Riley (Eds.), Melanins and Melanosomes: Biosynthesis, Biogenesis, Physiological, and Pathological Functions, (pp. 225-246). Weinheim: Wiley-V C H Verlag Gmbh.
  • Double, K., Halliday, G., Reyes, S. (2011). Substantia Nigra, Ventral Tegmental Area and Retrorubral Fields. In Juergen K. Mai & George Paxinos (Eds.), The Human Nervous System, 3rd Edition, (pp. 439-455). London: Academic Press.

2010

  • Kurz, A., Double, K., Lastres-Becker, I., Tozzi, A., Tantucci, M., Bockhart, V., Bonin, M., Garcia-Arencibia, M., Nuber, S., Schlaudraff, F. (2010). A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS One, 5(7), 1-15. [More Information]
  • Werry, E., Enjeti, S., Halliday, G., Sachdev, P., Double, K. (2010). Effect of age on proliferation-regulating factors in human adult neurogenic areas. Journal of Neurochemistry, 115(4), 956-964. [More Information]
  • Schofield, E., Halliday, G., Kwok, J., Loy, C., Double, K., Hodges, J. (2010). Low Serum Progranulin Predicts the Presence of Mutations: A Prospective Study. Journal of Alzheimer's Disease, 22(3), 981-984. [More Information]
  • Double, K., Todd, G., Duma, S. (2010). Pathophysiology of transcranial sonography signal changes in the human substantia nigra. International Review of Neurobiology, 90(C), 107-120. [More Information]
  • Double, K., Halliday, G., Dunkley, P., Dickson, P., Gerlach, M., Riederer, P. (2010). Pigmentation in the human brain and risk of Parkinson's disease. Annals of Neurology, 67(4), 553-554. [More Information]
  • Double, K., Reyes, S., Werry, E., Halliday, G. (2010). Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions? Progress in Neurobiology, 92(3), 316-329. [More Information]

2009

  • Double, K., Rowe, D., Carew-Jones, F., Hayes, M., Chan, D., Blackie, J., Corbett, A., Joffe, R., Fung, V., Morris, J., et al (2009). Anti-melanin antibodies are increased in sera in Parkinson's disease. Experimental Neurology, 217, 297-301. [More Information]
  • Piguet, O., Double, K., Kril, J., Harasty, J., Macdonald, V., McRitchie, D., Halliday, G. (2009). White matter loss in healthy ageing: A postmortem analysis. Neurobiology of Aging, 30(8), 1288-1295. [More Information]

2008

  • Sutherland, G., Mellick, G., Newman, J., Double, K., Stevens, J., Lee, L., Rowe, D., Silburn, P., Halliday, G. (2008). Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B (4), 495-499. [More Information]
  • Bohic, S., Murphy, K., Paulus, W., Cloetens, P., Salome, M., Susini, J., Double, K. (2008). Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy. Analytical Chemistry, 80(24), 9557-9566. [More Information]
  • Gerlach, M., Riederer, P., Double, K. (2008). Neuromelanin-bound ferric iron as an experimental model of dopaminergic neurodegeneration in Parkinson's disease. Parkinsonism and Related Disorders, 14(Suppl. 2), S185-S188. [More Information]
  • Double, K., Dedov, V., Fedorow, H., Kettle, E., Halliday, G., Garner, B., Brunk, U. (2008). The comparative biology of neuromelanin and lipofuscin in the human brain. Cellular and Molecular Life Sciences, 65, 1669-1682. [More Information]

2007

  • Gerlach, M., Deckert, J., Double, K., Koutsilieri, E. (2007). Journal of Neural Transmission, Supplementa: Preface. Journal of Neural Transmission, Supplementa, 27, V-VI.
  • Dedov, V., Griffiths, F., Garner, B., Halliday, G., Double, K. (2007). Lipid content determines aggregation of neuromelanin granules in vitro. Journal of Neural Transmission, Supplementa, 72, 35-38. [More Information]
  • Gerlach, M., Deckert, J., Double, K., Koutsilieri, E. (2007). Neuropyschiatric disorders: an integrative approach. J. Neural Trans. Suppl 72. New York: Springer.
  • Behnke, S., Double, K., Duma, S., Broe, G., Guenther, V., Becker, G., Halliday, G. (2007). Substantia nigra echomorphology in the healthy very old: Correlation with motor slowing. NeuroImage, 34(3), 1054-1059. [More Information]
  • Behnke, S., Double, K., Duma, S., Broe, G., Guenther, V., Becker, G., Halliday, G. (2007). Substantia nigra echomorphology in the healthy very old: Correlation with motor slowing. NeuroImage, 34(3), 1054-1059.

2006

  • Halliday, G., Fedorow, H., Rickert, C., Gerlach, M., Riederer, P., Double, K. (2006). Evidence for specific phases in the development of human neuromelanin. Journal of Neural Transmission, 113, 721-728. [More Information]
  • Fedorow, H., Halliday, G., Rickert, C., Gerlach, M., Riederer, P., Double, K. (2006). Evidence for specific phases in the development of human neuromelanin. Neurobiology of Aging, 27(3), 506-512. [More Information]
  • Fedorow, H., Pickford, R., Kettle, E., Cartwright, M., Halliday, G., Gerlach, M., Riederer, P., Garner, B., Double, K. (2006). Investigation of the lipid component of neuromelanin. Journal of Neural Transmission, 113, 735-739. [More Information]

2005

  • Fedorow, H., Pickford, R., Hook, J., Double, K., Halliday, G., Gerlach, M., Riederer, P., Garner, B. (2005). Dolichol is the major lipid component of human substantia nigra neuromelanin. Journal of Neurochemistry, 92, 990-995. [More Information]
  • Fedorow, H., Tribl, F., Halliday, G., Gerlach, M., Riederer, P., Double, K. (2005). Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson’s disease. Progress in Neurobiology, 75, 109-124. [More Information]
  • Halliday, G., Ophof, A., Broe, M., Jensen, P., Kettle, E., Fedorow, H., Cartwright, M., Griffiths, F., Shepherd, C., Double, K. (2005). α-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease. Brain, 128, 2654-2664.

2003

  • Halliday, G., Double, K., Macdonald, V., Kril, J. (2003). Identifying severely atrophic cortical subregions in Alzheimer's disease. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 24(6), 797-806.
  • Double, K., Rowe, D., Hayes, M., Chan, D., Blackie, J., Corbett, A., Joffe, R., Fung, V., Morris, J., Halliday, G. (2003). Identifying the Pattern of Olfactory Deficits in Parkinson Disease Using the Brief Smell Identification Test. JAMA Neurology, 60(4), 545-549. [More Information]
  • Double, K., Halliday, G., Henderson, J., Griffiths, F., Heinemann, T., Riederer, P., Gerlach, M. (2003). The dopamine receptor agonist lisuride attenuates iron-mediated dopaminergic neurodegeneration. Experimental Neurology, 184(1), 530-535. [More Information]

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