Dr Kelly McKelvey

Postdoctoral Research Fellow
Kolling Institute of Medical Research, Northern Clinical School

Telephone +61 2 99264830

Website Perinatal Medicine - Basic Science

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Biographical details

Dr Kelly McKelvey joined the Perinatal Research Laboratory at the Kolling Institute of Medical Research, University of Sydney in April 2014.

Research interests

My work investigates the immunological processes contributing to maternal and fetal death attributed to intrauterine growth restriction (IUGR) and associated complications.

IUGR is a condition during pregnancy where the fetal weight is <10th percentile for its sex, gestational age and growth potential. Each year it affects It affects 18,200 babies in Australia and leads to over 2.4 million perinatal deaths world wide. For those whic survive in utero, babies born with IUGR are at an increased rick for developing neurological disorders, diabetes, obesity and cardiovasular disease.

There is currently no cure for IUGR during pregnancy. The only option is pre-term delivery of the baby, which has its own set of health complications. My work aims to improve perinatal development by promoting the pregnancy to term and increasing fetal health in utero thereby redugin the life-long risk of chroni diseases in the child.

Specifically, my work utilises a mouse model (CBA/CaH female x DBA/2J male) of spontaneous IUGR and perinatal mortality which mimics aspects of the human IUGRcondition, including abnormal maternal immune response and placental structure.

Therapeutically we (in conjuction with Dr Sharon McCracken) are investigating how small cell fragments called exosomes, regulate the immune system during a healthy pregnancy and what goes wrong during in IUGR-complicated pregnancies. We hope to translate this work into a novel therapy for treatment of IUGR to save the lives of both mother and baby.

Teaching and supervision

Research only.

Honours projects are available for 2016:

1. 'Immune Response in a Murine Model of Intrauterine Growth Restriction and Perinatal Mortality'

2. 'Placentally derived exosomes are the key to controlling maternal immunity and Intra uterine Growth Restriction'

Please contact me for further details (kelly.mckelvey@sydney.edu.au).

Current projects

"Working towards a new therapy for the prevention of impaired fetal growth" - NHMRC grant (GNT1066606; 2014-2016)

Honours projects are available for 2016:

1. 'Immune Response in a Murine Model of Intrauterine Growth Restriction and Perinatal Mortality'

2. 'Placentally derived exosomes are the key to controlling maternal immunity and Intra uterine Growth Restriction'

Please contact me for further details (kelly.mckelvey@sydney.edu.au).

Associations

Royal North Shore Hospital Scientific Staff Council (RNSH SSC)

Lifespan Research Network

Australasian Society for Immunology (ASI)

Australia and New Zealand Placental Research Association (ANZPRA)

International Federation of Placena Associations (IFPA)

Awards and honours

Kolling Institute Travel Award, Domestic (2015)

Kolling Institute

Ramsay Health Care Australasian Travel Fellowship (2015)

RNSH Scientific Staff Council

Ulysses Club Arthritis Research Fellowship (2011-2014)

Ulysses Club Inc.

Best Basic Science Poster (2013)

Australian Rheumatology Association

Beryl and Jack Jacobs Australasian Travel Award (2013)

Royal North Shore Hospital

Janssen Conjoint Conference Early Career Researcher Oral Prize (2012)

Combined Australasian Wound and Tissue Repair Society and Australian Dermatology Society

Ramsay Healthcare, Australasian Travel Fellowship (2012)

RNSH Scientific Staff Council

Top Achiever Doctoral Scholarship (2007-2010)

Tertiary Education Commission New Zealand

Selected grants

2011

  • Effects of activated protein C on B-lymphocytes in Rheumatoid arthritis; McKelvey K; Ulysses Club Arthritis Research Fund/Research Fellowship.

Selected publications

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Journals

  • Whitmont, K., McKelvey, K., Fulcher, G., Reid, I., March, L., Xue, M., Cooper, A., Jackson, C. (2015). Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial. International Wound Journal, 12(4), 422-427. [More Information]
  • McKelvey, K., Jackson, C., Xue, M. (2014). Activated protein C: A regulator of human skin epidermal keratinocyte function. World Journal of Biological Chemistry, 5(2), 169-179. [More Information]
  • Xue, M., McKelvey, K., Shen, K., Minhas, N., March, L., Park, S., Jackson, C. (2014). Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology, 53(12), 2270-2279. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research & Therapy, 16(1), 1-12. [More Information]
  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • McKelvey, K., Appleton, I. (2012). Epicatechin gallate improves healing and reduces scar formation of incisional wounds in type 2 diabetes mellitus rat model. Wounds, 24(3), 55-57.
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • McKelvey, K., Highton, J., Hessian, P. (2011). Cell-specific expression of TLR9 isoforms in inflammation. Journal of Autoimmunity, 36(1), 78-86. [More Information]

2015

  • Whitmont, K., McKelvey, K., Fulcher, G., Reid, I., March, L., Xue, M., Cooper, A., Jackson, C. (2015). Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial. International Wound Journal, 12(4), 422-427. [More Information]

2014

  • McKelvey, K., Jackson, C., Xue, M. (2014). Activated protein C: A regulator of human skin epidermal keratinocyte function. World Journal of Biological Chemistry, 5(2), 169-179. [More Information]
  • Xue, M., McKelvey, K., Shen, K., Minhas, N., March, L., Park, S., Jackson, C. (2014). Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology, 53(12), 2270-2279. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research & Therapy, 16(1), 1-12. [More Information]

2013

  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]

2012

  • McKelvey, K., Appleton, I. (2012). Epicatechin gallate improves healing and reduces scar formation of incisional wounds in type 2 diabetes mellitus rat model. Wounds, 24(3), 55-57.
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.

2011

  • McKelvey, K., Highton, J., Hessian, P. (2011). Cell-specific expression of TLR9 isoforms in inflammation. Journal of Autoimmunity, 36(1), 78-86. [More Information]

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