Dr Kelly McKelvey

Sydney Neuro-Oncology Group / Sydney Vital Inflammation Flagship Fellow

Telephone +61 2 99264713

Website Sydney Neuro-Oncology Group
Sydney Vital
Bill Walsh Translational Cancer Research

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Biographical details

Dr Kelly McKelvey joined the Sydney Neuro-Oncology Group (SNOG) and Sydney Vital, Bill Walsh Translational Cancer Research Laboratory at the Sydney Medical School Northern, University of Sydney in May 2017.

Research interests

My work investigates the interactions between brain cancer cells and the patients immune system, during cancer development and following chemo- and/or radiation therapy.

In Australia one individual is diagnosed with brain cancer every 5 hours. Despite improvements in survival for other cancers (e.g. ovarian, prostate, breast), the average survival time for a patient with brain cancer remains 10-14 months.

It is recognised that the patient immune system supports brain cancer growth and relapse. Following therapy (chemo or radiation) the immune system also contributes to side effects and pooroer patient outcomes. However, the specific mechanisms are poorly understood.

My research provides greater understanding of the interactions of cancer and patient inflammatory systems during cancer growth, and therapy. The outcomes will support early diagnosis, achieve brain cancer remission, and alleviate the detrimental systemic inflammatory response which results in poorer patient outcomes.

Teaching and supervision

Research only.

Current research students

Project title Research student
Working towards a new therapy for the prevention of impaired fetal growth. Gaayathri ARIYAKUMAR

Current projects

  • Inflammation: A roadblock to response and recovery in brain cancer
  • Tissue toxicity and immune-related adverse events of a novel combination therapy for cancer

Associations

Sydney Neuro-Oncology Group (SNOG)

Sydney Vital

Cooperative Trails Group for Neuro-Oncology (COGNO)

Royal North Shore Hospital Scientific Staff Council (RNSH SSC)

Lifespan Research Network

Australasian Society for Immunology (ASI)

Awards and honours

Sydney Vital Domestic Travel Award (2017)

Sydney Vital

Sydney Neuro-Oncology Group / Sydney Vital Inflammation Flagship Fellowship (2017)

SNOG & Sydney Vital

MediKane Oral Presentation Prize (2015)

MediKane Pty Ltd

Kolling Institute Travel Award, Domestic (2015)

Kolling Institute

Ramsay Health Care Australasian Travel Fellowship (2015)

RNSH Scientific Staff Council

Ulysses Club Arthritis Research Fellowship (2011-2014)

Ulysses Club Inc.

Best Basic Science Poster (2013)

Australian Rheumatology Association

Beryl and Jack Jacobs Australasian Travel Award (2013)

Royal North Shore Hospital

Janssen Conjoint Conference Early Career Researcher Oral Prize (2012)

Combined Australasian Wound and Tissue Repair Society and Australian Dermatology Society

Ramsay Healthcare, Australasian Travel Fellowship (2012)

RNSH Scientific Staff Council

Top Achiever Doctoral Scholarship (2007-2010)

Tertiary Education Commission New Zealand

Selected grants

2017

  • Inflammation: A roadblock to response and recovery in Brain Cancer; McKelvey K; Sydney Vital Translational Cancer Research/Flagship 1 Fellowship.
  • Investigating Inflammation and Coagulation in Brain Cancer; Howell V, Hudson A, Wheeler H, McKelvey K; Sydney Neuro-Oncology Group/Research Grant.

2011

  • Effects of activated protein C on B-lymphocytes in Rheumatoid arthritis; McKelvey K; Ulysses Club Arthritis Research Fund/Research Fellowship.

Selected publications

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Journals

  • Nguyen, T., McKelvey, K., March, L., Hunter, D., Xue, M., Jackson, C., Morris, J. (2016). Aberrant levels of natural IgM antibodies in osteoarthritis and rheumatoid arthritis patients in comparison to healthy controls. Immunology Letters, 170, 27-36. [More Information]
  • McKelvey, K., Yenson, V., Ashton, A., Morris, J., McCracken, S. (2016). Embryonic/fetal mortality and intrauterine growth restriction is not exclusive to the CBA/J sub-strain in the CBA � DBA model. Scientific Reports, 6, 1-11. [More Information]
  • McKelvey, K., Powell, K., Ashton, A., Morris, J., McCracken, S. (2015). Exosomes: Mechanisms of Uptake. Journal of Circulating Biomarkers, 4(7), 1-9. [More Information]
  • Whitmont, K., McKelvey, K., Fulcher, G., Reid, I., March, L., Xue, M., Cooper, A., Jackson, C. (2015). Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial. International Wound Journal, 12(4), 422-427. [More Information]
  • McKelvey, K., Jackson, C., Xue, M. (2014). Activated protein C: A regulator of human skin epidermal keratinocyte function. World Journal of Biological Chemistry, 5(2), 169-179. [More Information]
  • Xue, M., McKelvey, K., Shen, K., Minhas, N., March, L., Park, S., Jackson, C. (2014). Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology, 53(12), 2270-2279. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), 1-12. [More Information]
  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • McKelvey, K., Appleton, I. (2012). Epicatechin gallate improves healing and reduces scar formation of incisional wounds in type 2 diabetes mellitus rat model. Wounds, 24(3), 55-57.
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • McKelvey, K., Highton, J., Hessian, P. (2011). Cell-specific expression of TLR9 isoforms in inflammation. Journal of Autoimmunity, 36(1), 76-86. [More Information]

2016

  • Nguyen, T., McKelvey, K., March, L., Hunter, D., Xue, M., Jackson, C., Morris, J. (2016). Aberrant levels of natural IgM antibodies in osteoarthritis and rheumatoid arthritis patients in comparison to healthy controls. Immunology Letters, 170, 27-36. [More Information]
  • McKelvey, K., Yenson, V., Ashton, A., Morris, J., McCracken, S. (2016). Embryonic/fetal mortality and intrauterine growth restriction is not exclusive to the CBA/J sub-strain in the CBA � DBA model. Scientific Reports, 6, 1-11. [More Information]

2015

  • McKelvey, K., Powell, K., Ashton, A., Morris, J., McCracken, S. (2015). Exosomes: Mechanisms of Uptake. Journal of Circulating Biomarkers, 4(7), 1-9. [More Information]
  • Whitmont, K., McKelvey, K., Fulcher, G., Reid, I., March, L., Xue, M., Cooper, A., Jackson, C. (2015). Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial. International Wound Journal, 12(4), 422-427. [More Information]

2014

  • McKelvey, K., Jackson, C., Xue, M. (2014). Activated protein C: A regulator of human skin epidermal keratinocyte function. World Journal of Biological Chemistry, 5(2), 169-179. [More Information]
  • Xue, M., McKelvey, K., Shen, K., Minhas, N., March, L., Park, S., Jackson, C. (2014). Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology, 53(12), 2270-2279. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), 1-12. [More Information]

2013

  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]

2012

  • McKelvey, K., Appleton, I. (2012). Epicatechin gallate improves healing and reduces scar formation of incisional wounds in type 2 diabetes mellitus rat model. Wounds, 24(3), 55-57.
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.

2011

  • McKelvey, K., Highton, J., Hessian, P. (2011). Cell-specific expression of TLR9 isoforms in inflammation. Journal of Autoimmunity, 36(1), 76-86. [More Information]

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