Dr Kelly McKelvey

Postdoctoral Fellow
Kolling Institute of Medical Research, Northern Clinical School

Telephone +61 2 99264848

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Biographical details

Dr Kelly McKelvey joined the Sutton Arthritis Research Laboratory at the Kolling Institute of Medical Research, University of Sydney in February 2011.

Prior to her employment at the University of Sydney she completed a PhD at the University of Otago, New Zealand in September 2010. Her thesis project was to investigate the role of a circulating blood cell, called the B-lymphocyte, in inflammation During her undergraduate studies she undertook research in the fields of diabetic wound healing (Honours; 2006) and stroke (Student Summer Research; 2005). Dr McKelvey is supported by the Ulysses Club Arthritis Research Fund (UCARF).

Research interests

My work is investigating the processes involved in arthritis, with the aim of developing better treatments for common disorders such as osteoarthritis and rheumatoid arthritis, which affect millions of Australians.

In the early 1990¿s a novel family of receptors called the protease-activated receptors (PARs) was discovered. As well as a role in blood clotting, these receptors are involved in suppressing (PAR1) and amplifying (PAR2) the tissue-destructive reaction that characterises arthritis. I am interested in the role of these receptors on B-lymphocytes, a circulating blood cell with a pivotal role in arthritis. I intend to target these receptors to modify the behaviour of B-lymphocytes, as a potential treatment for arthritis. If successful, this therapy could be advanced to treat other B-lymphocyte-related disorders, including type I diabetes and multiple sclerosis.

Teaching and supervision

Research only.

Selected grants

2011

  • Effects of activated protein C on B-lymphocytes in Rheumatoid arthritis; McKelvey K; Ulysses Club Arthritis Research Fund/Research Fellowship.

Selected publications

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Journals

  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), R44. [More Information]
  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • McKelvey, K., Highton, J., Hessian, P. (2011). Cell-specific expression of TLR9 isoforms in inflammation. Journal of Autoimmunity, 36(1), 78-86. [More Information]

2014

  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), R44. [More Information]

2013

  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]

2012

  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.

2011

  • McKelvey, K., Highton, J., Hessian, P. (2011). Cell-specific expression of TLR9 isoforms in inflammation. Journal of Autoimmunity, 36(1), 78-86. [More Information]

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