Dr Kenneth Mewett

Honorary Associate
Pharmacology, School of Medical Sciences

Telephone +61 2 91140509
Fax +61 2 9351 3868

Map

Selected grants

2006

  • GABA modulators for the treatment of anxiety, epilepsy and insomnia; Johnston G, Hanrahan J, Collins M, Mewett K; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Nguyen, T., Vo, T., Bui, V., Le, V., Nguyen, T., Bui, C., Pham, N., Pham, H., Pham, T., Chu, P., Allan, R., Mewett, K., Tran, H., Khurana, J., Wang, S., Kennedy, I., Lee, N. (2007). Application of a Cyclodiene-Specific ELISA to Residue Monitoring of Agricultural Produce and the Environment in Vietnam. In I.R. Kennedy; K.R. Solomon; S.J. Gee; A.N. Crossan; S. Wang; F. Sanchez-Bayo (Eds.), Rational Environmental Management of Agrochemicals: Risk Assessment, Monitoring, and Remedial Action, (pp. 245-258). Washington DC, United States: American Chemical Society.
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]

Journals

  • Fernandez, S., Karim, N., Mewett, K., Collins, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Collins, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Greenwood, J., Mewett, K., Allan, R., Martín, B., Pickering, D. (2006). 3-Hydroxypyridazine 1-oxides as carboxylate bioisosteres: A new series of subtype-selective AMPA receptor agonists. Neuropharmacology, 51(1), 52-59. [More Information]
  • Hanrahan, J., Mewett, K., Collins, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Duke, R., Collins, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751.
  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Collins, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889.
  • Hanrahan, J., Mewett, K., Collins, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.

Conferences

  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.

2012

  • Fernandez, S., Karim, N., Mewett, K., Collins, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]

2011

  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]

2010

  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]

2009

  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]

2008

  • Fernandez, S., Mewett, K., Hanrahan, J., Collins, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]

2007

  • Collins, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Nguyen, T., Vo, T., Bui, V., Le, V., Nguyen, T., Bui, C., Pham, N., Pham, H., Pham, T., Chu, P., Allan, R., Mewett, K., Tran, H., Khurana, J., Wang, S., Kennedy, I., Lee, N. (2007). Application of a Cyclodiene-Specific ELISA to Residue Monitoring of Agricultural Produce and the Environment in Vietnam. In I.R. Kennedy; K.R. Solomon; S.J. Gee; A.N. Crossan; S. Wang; F. Sanchez-Bayo (Eds.), Rational Environmental Management of Agrochemicals: Risk Assessment, Monitoring, and Remedial Action, (pp. 245-258). Washington DC, United States: American Chemical Society.

2006

  • Greenwood, J., Mewett, K., Allan, R., Martín, B., Pickering, D. (2006). 3-Hydroxypyridazine 1-oxides as carboxylate bioisosteres: A new series of subtype-selective AMPA receptor agonists. Neuropharmacology, 51(1), 52-59. [More Information]
  • Hanrahan, J., Mewett, K., Collins, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.

2004

  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Duke, R., Collins, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751.

2003

  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.

2002

  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Collins, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889.

2001

  • Hanrahan, J., Mewett, K., Collins, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.

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