Dr Kenneth Micklethwaite

Clinical Lecturer
Medicine, Westmead Clinical School
The Westmead Institute for Medical Research

Telephone 9845 8279
Fax 96892331

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Selected grants

2016

  • A Phase I Study of PiggyBac CD19 Specific Chimeric Antigen Receptor T-cells for Therapy of Persistent and Relapsed B-cell Leukaemia and Lymphoma Post Allogeneic Stem Cell Transplantation (The CARTELL Study); Micklethwaite K, Dalla-Pozza L, Gottlieb D, O'Brien T, Trahair T, Clancy L, Blyth E, Shaw P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Coadministration of malignancy and infection specific T cells after allogeneic stem cell transplant for acute leukaemia with CD34+ stem cells; Gottlieb D, Micklethwaite K, Blyth E; Cancer Council New South Wales/Research Project Grants.

2015

  • Gene modified T cells expressing a chimeric antigen receptor for a kappa light chain antigen to treat multiple myeloma; Micklethwaite K, Harrison S; Cancer Council New South Wales/Research Project Grants.

2014

  • WAVE 20/50 Bioreactor and C5 Cell Disruptor; Chircop (nee Fabbro) M, Kizana E, Robinson P, Diefenbach R, Bryan T, Gottlieb D, Micklethwaite K, Alexander I; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Production of Off The Shelf T-cells Expressing a Non-MHC Restricted CD19 Specific Chimeric Antigen Receptor for use in a Phase I Study of T-cell Therapy of Relapsed and Refractory B-Cell Malignancies (UNI-T Study); Micklethwaite K; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.

2012

  • Redirecting T-cells for immunotherapy of leukaemia and lymphoma by the expression of a CD19-specific chimeric antigen receptor using the PiggyBac transposon gene modification system; Micklethwaite K; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Generation of Hodgkin specific T-cells and overcoming tumour immune evasion; Micklethwaite K; Cancer Institute New South Wales/International Clinical and Research Fellowship.

2005

  • Clinical Research Fellowship Grant; Micklethwaite K; The Leukaemia Foundation of Australia Limited/Postdoctoral Fellowship.

Selected publications

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Journals

  • Kong, B., Micklethwaite, K., Swaminathan, S., Kefford, R., Carlino, M. (2016). Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma. Melanoma Research, 26(2), 202-204. [More Information]
  • Ma, C., Blyth, E., Clancy, L., Simms, R., Burgess, J., Brown, R., Deo, S., Micklethwaite, K., Gottlieb, D. (2015). Addition of varicella zoster virus-specific T cells to cytomegalovirus, Epstein-Barr virus and adenovirus tri-specific T cells as adoptive immunotherapy in patients undergoing allogeneic hematopoietic stem cell transplantation. Cytotherapy, 17(10), 1406-1420. [More Information]
  • Macesic, N., Langsford, D., Nicholls, K., Hughes, P., Gottlieb, D., Clancy, L., Blyth, E., Micklethwaite, K., Withers, B., Majumdar, S., et al (2015). Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient. American Journal Of Transplantation, 15(3), 827-832. [More Information]
  • Dolnikov, A., Shen, S., Klamer, G., Joshi, S., Xu, N., Yang, L., Micklethwaite, K., O'Brien, T. (2015). Anti-leukemic potency of CD19-specific T cells against chemoresistant paediatric acute lymphoblastic leukaemia. Experimental Hematology, 43(12), 1001-1014. [More Information]
  • Ramanayake, S., Bilmon, I., Bishop, D., Dubosq, M., Blyth, E., Clancy, L., Gottlieb, D., Micklethwaite, K. (2015). Low-cost generation of Good Manufacturing Practice-grade CD19-specific chimeric antigen receptor-expressing T cells using piggyBac gene transfer and patient-derived materials. Cytotherapy, 17(9), 1251-1267. [More Information]
  • Clancy, L., Blyth, E., Simms, R., Micklethwaite, K., Ma, C., Burgess, J., Antonenas, V., Shaw, P., Gottlieb, D. (2013). Cytomegalovirus-specific cytotoxic T lymphocytes can be efficiently expanded from granulocyte colony-stimulating factor-mobilized hemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplantation recipients to facilitate immune reconstitution. Biology of Blood and Marrow Transplantation, 19(5), 725-734. [More Information]
  • Blyth, E., Clancy, L., Simms, R., Ma, C., Burgess, J., Deo, S., Byth Wilson, K., Dubosq, M., Shaw, P., Micklethwaite, K., Gottlieb, D. (2013). Donor-derived CMV specific T-cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation. Blood, 121(18), 3745-3758. [More Information]
  • Cruz, C., Micklethwaite, K., Savoldo, B., Ramos, C., Lam, S., Ku, S., Diouf, O., Liu, E., Barrett, A., Ito, S., et al (2013). Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study. Blood, 122(17), 2965-2973. [More Information]
  • Blyth, E., Deo, S., Clancy, L., Simms, R., Bilmon, I., Micklethwaite, K., Gottlieb, D. (2012). Clinical-grade varicella zoster virus-specific T cells produced for adoptive immunotherapy in hemopoietic stem cell transplant recipients. Cytotherapy, 14(6), 724-732. [More Information]
  • Blyth, E., Clancy, L., Simms, R., Deo, S., O'Connell, P., Micklethwaite, K., Gottlieb, D. (2011). BK Virus-Specific T Cells for Use in Cellular Therapy Show Specificity to Multiple Antigens and Polyfunctional Cytokine Responses. Transplantation, 92(10), 1077-1084. [More Information]
  • Micklethwaite, K., Savoldo, B., Hanley, P., Leen, A., Demmler-Harrison, G., Cooper, L., Liu, H., Gee, A., Shpall, E., Rooney, C., et al (2010). Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation. Blood, 115(13), 2695-2703. [More Information]
  • Micklethwaite, K., Garvin, F., Kariotis, M., Yee, L., Hansen, A., Antonenas, V., Sartor, M., Turtle, C., Gottlieb, D. (2009). Clinical-scale elutriation as a means of enriching antigen-presenting cells and manipulating alloreactivity. Cytotherapy, 11(2), 218-228. [More Information]
  • Micklethwaite, K., Clancy, L., Sandher, U., Hansen, A., Blyth, E., Antonenas, V., Sartor, M., Bradstock, K., Gottlieb, D. (2008). Prophylactic infusion of cytomegalovirus specific cytotoxic T-lymphocytes stimulated with Ad5f35pp65 gene modified dendritic cells following allogeneic haemopoietic stem cell transplantation. Blood, 112(10), 3974-3981. [More Information]
  • Micklethwaite, K., Hansen, A., Foster, A., Snape, E., Antonenas, V., Sartor, M., Shaw, P., Bradstock, K., Gottlieb, D. (2007). Ex vivo expansion and prophylactic infusion of CMV-pp65 peptide-specific cytotoxic T-lymphocytes following allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation, 13(6), 707-714. [More Information]
  • Gottlieb, D., Micklethwaite, K., Bradstock, K., Li, Y. (2007). Rapid expansion of tumor-reactive cells from HLA-matched siblings for adoptive immunotherapy of melanoma. Cytotherapy, 9(2), 133-143. [More Information]

Conferences

  • Hansen, A., Micklethwaite, K., Foster, A., Bradstock, K., Gottlieb, D. (2006). Ex vivo expansion of clinical grade CMV specific CTL for therapeutic use in allogeneic haemopoietic stem cell transplantation. 2nd International Conference 'Strategies in Tissue Engineering', United Kingdom: Informa Healthcare.
  • Gottlieb, D., Hansen, A., Micklethwaite, K., Foster, A., Turtle, C., Antonenas, V., Sartor, M., Bradstock, K. (2005). Ex-vivo expansion and prophylactic infusion of CMV pp65 specific CTL following haemopoietic stem cell transplantation (HSCT). 47th Annual Meeting of the American Society of Hematology (ASH), United States: American Society of Hematology.

2016

  • Kong, B., Micklethwaite, K., Swaminathan, S., Kefford, R., Carlino, M. (2016). Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma. Melanoma Research, 26(2), 202-204. [More Information]

2015

  • Ma, C., Blyth, E., Clancy, L., Simms, R., Burgess, J., Brown, R., Deo, S., Micklethwaite, K., Gottlieb, D. (2015). Addition of varicella zoster virus-specific T cells to cytomegalovirus, Epstein-Barr virus and adenovirus tri-specific T cells as adoptive immunotherapy in patients undergoing allogeneic hematopoietic stem cell transplantation. Cytotherapy, 17(10), 1406-1420. [More Information]
  • Macesic, N., Langsford, D., Nicholls, K., Hughes, P., Gottlieb, D., Clancy, L., Blyth, E., Micklethwaite, K., Withers, B., Majumdar, S., et al (2015). Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient. American Journal Of Transplantation, 15(3), 827-832. [More Information]
  • Dolnikov, A., Shen, S., Klamer, G., Joshi, S., Xu, N., Yang, L., Micklethwaite, K., O'Brien, T. (2015). Anti-leukemic potency of CD19-specific T cells against chemoresistant paediatric acute lymphoblastic leukaemia. Experimental Hematology, 43(12), 1001-1014. [More Information]
  • Ramanayake, S., Bilmon, I., Bishop, D., Dubosq, M., Blyth, E., Clancy, L., Gottlieb, D., Micklethwaite, K. (2015). Low-cost generation of Good Manufacturing Practice-grade CD19-specific chimeric antigen receptor-expressing T cells using piggyBac gene transfer and patient-derived materials. Cytotherapy, 17(9), 1251-1267. [More Information]

2013

  • Clancy, L., Blyth, E., Simms, R., Micklethwaite, K., Ma, C., Burgess, J., Antonenas, V., Shaw, P., Gottlieb, D. (2013). Cytomegalovirus-specific cytotoxic T lymphocytes can be efficiently expanded from granulocyte colony-stimulating factor-mobilized hemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplantation recipients to facilitate immune reconstitution. Biology of Blood and Marrow Transplantation, 19(5), 725-734. [More Information]
  • Blyth, E., Clancy, L., Simms, R., Ma, C., Burgess, J., Deo, S., Byth Wilson, K., Dubosq, M., Shaw, P., Micklethwaite, K., Gottlieb, D. (2013). Donor-derived CMV specific T-cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation. Blood, 121(18), 3745-3758. [More Information]
  • Cruz, C., Micklethwaite, K., Savoldo, B., Ramos, C., Lam, S., Ku, S., Diouf, O., Liu, E., Barrett, A., Ito, S., et al (2013). Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study. Blood, 122(17), 2965-2973. [More Information]

2012

  • Blyth, E., Deo, S., Clancy, L., Simms, R., Bilmon, I., Micklethwaite, K., Gottlieb, D. (2012). Clinical-grade varicella zoster virus-specific T cells produced for adoptive immunotherapy in hemopoietic stem cell transplant recipients. Cytotherapy, 14(6), 724-732. [More Information]

2011

  • Blyth, E., Clancy, L., Simms, R., Deo, S., O'Connell, P., Micklethwaite, K., Gottlieb, D. (2011). BK Virus-Specific T Cells for Use in Cellular Therapy Show Specificity to Multiple Antigens and Polyfunctional Cytokine Responses. Transplantation, 92(10), 1077-1084. [More Information]

2010

  • Micklethwaite, K., Savoldo, B., Hanley, P., Leen, A., Demmler-Harrison, G., Cooper, L., Liu, H., Gee, A., Shpall, E., Rooney, C., et al (2010). Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation. Blood, 115(13), 2695-2703. [More Information]

2009

  • Micklethwaite, K., Garvin, F., Kariotis, M., Yee, L., Hansen, A., Antonenas, V., Sartor, M., Turtle, C., Gottlieb, D. (2009). Clinical-scale elutriation as a means of enriching antigen-presenting cells and manipulating alloreactivity. Cytotherapy, 11(2), 218-228. [More Information]

2008

  • Micklethwaite, K., Clancy, L., Sandher, U., Hansen, A., Blyth, E., Antonenas, V., Sartor, M., Bradstock, K., Gottlieb, D. (2008). Prophylactic infusion of cytomegalovirus specific cytotoxic T-lymphocytes stimulated with Ad5f35pp65 gene modified dendritic cells following allogeneic haemopoietic stem cell transplantation. Blood, 112(10), 3974-3981. [More Information]

2007

  • Micklethwaite, K., Hansen, A., Foster, A., Snape, E., Antonenas, V., Sartor, M., Shaw, P., Bradstock, K., Gottlieb, D. (2007). Ex vivo expansion and prophylactic infusion of CMV-pp65 peptide-specific cytotoxic T-lymphocytes following allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation, 13(6), 707-714. [More Information]
  • Gottlieb, D., Micklethwaite, K., Bradstock, K., Li, Y. (2007). Rapid expansion of tumor-reactive cells from HLA-matched siblings for adoptive immunotherapy of melanoma. Cytotherapy, 9(2), 133-143. [More Information]

2006

  • Hansen, A., Micklethwaite, K., Foster, A., Bradstock, K., Gottlieb, D. (2006). Ex vivo expansion of clinical grade CMV specific CTL for therapeutic use in allogeneic haemopoietic stem cell transplantation. 2nd International Conference 'Strategies in Tissue Engineering', United Kingdom: Informa Healthcare.

2005

  • Gottlieb, D., Hansen, A., Micklethwaite, K., Foster, A., Turtle, C., Antonenas, V., Sartor, M., Bradstock, K. (2005). Ex-vivo expansion and prophylactic infusion of CMV pp65 specific CTL following haemopoietic stem cell transplantation (HSCT). 47th Annual Meeting of the American Society of Hematology (ASH), United States: American Society of Hematology.

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