Dr Kerrie McDonald

Honorary Senior Research Fellow
NHMRC Clinical Trials Centre, Sydney Medical School

Telephone +61 2 93851471
Fax +61 2 93851510

Map

Selected grants

2013

  • The biological basis of success or failure to the anti-VEGF agent, bevacizumab in patients with recurrent glioblastoma; Simes R, McDonald K, Brown C, Yip S; Cancer Council New South Wales/Research Project Grants.
  • COGNO infrastructure funding for support, development and conduct of clinical trials and translational research; Hovey E, Simes R, Koh E, Agar M, McDonald K, Wheeler H; Cancer Institute New South Wales/Cooperative Clinical Trial (CCT) Grants.

2009

  • The role of IQGAP1 in actively migrating glioma cells and its regulation by MiR-124; McDonald K, Bennett M, Davey R, Robinson B; Cancer Council New South Wales/Research Project Grants.

2008

  • Can we find genes that predict which GBM patient will become a long term survivor?; McDonald K; Cure for Life Foundation/Fellowship.
  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • Can we find genes that predict which GBM patient will become a long term survivor?; McDonald K; Schering Plough/Research Enabling Grant.
  • Oligodendrogliomas with LOH 1p/19q: identifying genes associated with therapeutic sensitivity; Robinson B, McDonald K; Cancer Institute New South Wales/Research Grant.
  • Delivering the right drug to the right patient: predictive biomarker discovery; McDonald K; Cure for Life Foundation/Research Grants.

Selected publications

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Book Chapters

  • Guest, D., Sutherland, A., McDonald, K. (2001). Sacrificial cell death in tobacco plants and isolation of an endogenous secondary cell death signal. In Feng Zhijie (Eds.), Plant Diseases and Their Control, (pp. Not known-Not known). China Agricultural Scientech Press.

Journals

  • Fowler, A., Thomson, D., Giles, K., Maleki, S., Mreich, E., Wheeler, H., Leedman, P., Biggs, M., Cook, R., Little, N., Robinson, B., McDonald, K. (2011). miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion. European Journal of Cancer, 47(6), 953-963. [More Information]
  • Gonzalvo, A., Fowler, A., Cook, R., Little, N., Wheeler, H., McDonald, K., Biggs, M. (2011). Schwannomatosis, sporadic schwannomatosis, and familial schwannomatosis: a surgical series with long-term follow-up. Journal of Neurosurgery. [More Information]
  • Parkinson, J., Afaghi, V., Payne, C., Buckland, M., Brewer, J., Biggs, M., Little, N., Wheeler, H., Cook, R., McDonald, K. (2011). The impact of molecular and clinical factors on patient outcome in oligodendroglioma from 20 years' experience at a single centre. Journal of Clinical Neuroscience, 18(3), 329-333. [More Information]
  • Matar, E., Cook, R., Fowler, A., Biggs, M., Little, N., Wheeler, H., Robinson, B., McDonald, K. (2010). Post-contrast enhancement as a clinical indicator of prognosis in patients with anaplastic astrocytoma. Journal of Clinical Neuroscience, 17(8), 993-996. [More Information]
  • McDonald, K., McDonnell, J., Muntoni, A., Henson, J., Hegi, M., von Deimling, A., Wheeler, H., Cook, R., Biggs, M., Little, N., Robinson, B., Reddel, R., et al (2010). Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival. Journal of Neuropathology and Experimental Neurology, 69(7), 729-736. [More Information]
  • McCormack, A., McDonald, K., Gill, A., Clark, S., Burt, M., Campbell, K., Braund, W., Little, N., Cook, R., Grossman, A., Robinson, B., Clifton-Bligh, R. (2009). Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours. Clinical Endocrinology, 71(2), 226-233. [More Information]
  • Soon, P., Gill, A., Benn, D., Clarkson, A., Robinson, B., McDonald, K., Sidhu, S. (2009). Microarray gene expression and immunohistochemistry analyses of adrenocortical tumours identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas. Endocrine-Related Cancer, 16(2), 573-583. [More Information]
  • Elston, M., Gill, A., Conaglen, J., Clarkson, A., Cook, R., Little, N., Robinson, B., Clifton-Bligh, R., McDonald, K. (2009). Nuclear Accumulation of E-Cadherin Correlates with Loss of Cytoplasmic Membrane Staining and Invasion in Pituitary Adenomas. Journal of Clinical Endocrinology and Metabolism, 94(4), 1436-1442. [More Information]
  • Parkinson, J., Wheeler, H., McDonald, K. (2008). Contribution of DNA repair mechanisms to determining chemotherapy response in high-grade glioma. Journal of Clinical Neuroscience, 15(1), 1-8. [More Information]
  • Soon, P., Libe, R., Benn, D., Gill, A., Shaw, J., Sywak, M., Groussin, L., Bertagna, X., Gicquel, C., Bertherat, J., McDonald, K., Sidhu, S., Robinson, B. (2008). Loss of Heterozygosity of 17p13, With Possible Involvement of ACADVL and ALOX15B, in the Pathogenesis of Adrenocortical Tumors. Annals of Surgery, 247(1), 157-164. [More Information]
  • Payne, C., Maleki, S., Messina, M., O'Sullivan, M., Stone, G., Hall, N., Parkinson, J., Wheeler, H., Cook, R., Biggs, M., Robinson, B., McDonald, K., et al (2008). Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. Molecular Cancer Therapeutics, 7(10), 3420-3428. [More Information]
  • Soon, P., McDonald, K., Robinson, B., Sidhu, S. (2008). Molecular markers and the pathogenesis of adrenocortical cancer. The Oncologist, 13(5), 548-561. [More Information]
  • Au, A., McDonald, K., Gill, A., Sywak, M., Diamond, T., Conigrave, A., Clifton-Bligh, R. (2008). PTH Mutation with Primary Hyperparathyroidism and Undetectable Intact PTH. New England Journal of Medicine, 359(11), 1184-1186. [More Information]
  • Fowler, A., Cook, R., Biggs, M., Little, N., Assaad, N., McDonald, K. (2008). Survival of patients following neurosurgical treatment of colorectal adenocarcinoma metastasis in the Northern Sydney-Central Coast area. Journal of Clinical Neuroscience, 15(9), 998-1004. [More Information]
  • Elston, M., Gill, A., Conaglen, J., Clarkson, A., Shaw, J., Law, A., Cook, R., Little, N., Clifton-Bligh, R., Robinson, B., McDonald, K. (2008). Wnt Pathway Inhibitors Are Strongly Down-Regulated in Pituitary Tumors. Endocrinology, 149(3), 1235-1242. [More Information]
  • Soon, P., Benn, D., Gill, A., Robinson, B., McDonald, K. (2007). Es07 microarray gene expression analysis of human adrenocortical tumours. ANZ Journal of Surgery, 77(Suppl.1), A22-A22. [More Information]
  • Parkinson, J., Wheeler, H., Clarkson, A., McKenzie, C., Biggs, M., Little, N., Cook, R., Messina, M., Robinson, B., McDonald, K. (2007). Variation of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma. Journal of Neuro-Oncology, DOI 10.1007/s11060-007-9486-0, 1-8. [More Information]
  • Perrone, S., McDonald, K., Sutherland, M., Guest, D. (2003). Superoxide release is necessary for phytoalexin accumulation in Nicotiana tabacum cells during the expression of cultivar-race and non-host resistance towards Phytophthora spp. Physiological and Molecular Plant Pathology, 62(3), 127-135.
  • McDonald, K. (2002). Dynamic neural activity as chaotic itinerancy or heteroclinic cycles? Behavioral and Brain Sciences, , 1-3.
  • McDonald, K., Sutherland, M., Guest, D. (2002). Temporary hypoxia suppresses the oxidative burst and subsequent hypersensitive cell death in cells of tobacco and soybean challenged with zoospores of incompatible isolates of Phytophthora species. Physiological and Molecular Plant Pathology, 61(2), 133-140.

Conferences

  • McConchie, R., Nguyen, P., McDonald, K., Anwaral, B., Morris, S. (2004). Systemic Acquired Resistance As A Strategy For Postharvest Disease Management On Rockmelon (Cucumis Melo Var. Reticulatus). 5th ISHS Postharvest Symposium, : University of Melbourne.

2011

  • Fowler, A., Thomson, D., Giles, K., Maleki, S., Mreich, E., Wheeler, H., Leedman, P., Biggs, M., Cook, R., Little, N., Robinson, B., McDonald, K. (2011). miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion. European Journal of Cancer, 47(6), 953-963. [More Information]
  • Gonzalvo, A., Fowler, A., Cook, R., Little, N., Wheeler, H., McDonald, K., Biggs, M. (2011). Schwannomatosis, sporadic schwannomatosis, and familial schwannomatosis: a surgical series with long-term follow-up. Journal of Neurosurgery. [More Information]
  • Parkinson, J., Afaghi, V., Payne, C., Buckland, M., Brewer, J., Biggs, M., Little, N., Wheeler, H., Cook, R., McDonald, K. (2011). The impact of molecular and clinical factors on patient outcome in oligodendroglioma from 20 years' experience at a single centre. Journal of Clinical Neuroscience, 18(3), 329-333. [More Information]

2010

  • Matar, E., Cook, R., Fowler, A., Biggs, M., Little, N., Wheeler, H., Robinson, B., McDonald, K. (2010). Post-contrast enhancement as a clinical indicator of prognosis in patients with anaplastic astrocytoma. Journal of Clinical Neuroscience, 17(8), 993-996. [More Information]
  • McDonald, K., McDonnell, J., Muntoni, A., Henson, J., Hegi, M., von Deimling, A., Wheeler, H., Cook, R., Biggs, M., Little, N., Robinson, B., Reddel, R., et al (2010). Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival. Journal of Neuropathology and Experimental Neurology, 69(7), 729-736. [More Information]

2009

  • McCormack, A., McDonald, K., Gill, A., Clark, S., Burt, M., Campbell, K., Braund, W., Little, N., Cook, R., Grossman, A., Robinson, B., Clifton-Bligh, R. (2009). Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours. Clinical Endocrinology, 71(2), 226-233. [More Information]
  • Soon, P., Gill, A., Benn, D., Clarkson, A., Robinson, B., McDonald, K., Sidhu, S. (2009). Microarray gene expression and immunohistochemistry analyses of adrenocortical tumours identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas. Endocrine-Related Cancer, 16(2), 573-583. [More Information]
  • Elston, M., Gill, A., Conaglen, J., Clarkson, A., Cook, R., Little, N., Robinson, B., Clifton-Bligh, R., McDonald, K. (2009). Nuclear Accumulation of E-Cadherin Correlates with Loss of Cytoplasmic Membrane Staining and Invasion in Pituitary Adenomas. Journal of Clinical Endocrinology and Metabolism, 94(4), 1436-1442. [More Information]

2008

  • Parkinson, J., Wheeler, H., McDonald, K. (2008). Contribution of DNA repair mechanisms to determining chemotherapy response in high-grade glioma. Journal of Clinical Neuroscience, 15(1), 1-8. [More Information]
  • Soon, P., Libe, R., Benn, D., Gill, A., Shaw, J., Sywak, M., Groussin, L., Bertagna, X., Gicquel, C., Bertherat, J., McDonald, K., Sidhu, S., Robinson, B. (2008). Loss of Heterozygosity of 17p13, With Possible Involvement of ACADVL and ALOX15B, in the Pathogenesis of Adrenocortical Tumors. Annals of Surgery, 247(1), 157-164. [More Information]
  • Payne, C., Maleki, S., Messina, M., O'Sullivan, M., Stone, G., Hall, N., Parkinson, J., Wheeler, H., Cook, R., Biggs, M., Robinson, B., McDonald, K., et al (2008). Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. Molecular Cancer Therapeutics, 7(10), 3420-3428. [More Information]
  • Soon, P., McDonald, K., Robinson, B., Sidhu, S. (2008). Molecular markers and the pathogenesis of adrenocortical cancer. The Oncologist, 13(5), 548-561. [More Information]
  • Au, A., McDonald, K., Gill, A., Sywak, M., Diamond, T., Conigrave, A., Clifton-Bligh, R. (2008). PTH Mutation with Primary Hyperparathyroidism and Undetectable Intact PTH. New England Journal of Medicine, 359(11), 1184-1186. [More Information]
  • Fowler, A., Cook, R., Biggs, M., Little, N., Assaad, N., McDonald, K. (2008). Survival of patients following neurosurgical treatment of colorectal adenocarcinoma metastasis in the Northern Sydney-Central Coast area. Journal of Clinical Neuroscience, 15(9), 998-1004. [More Information]
  • Elston, M., Gill, A., Conaglen, J., Clarkson, A., Shaw, J., Law, A., Cook, R., Little, N., Clifton-Bligh, R., Robinson, B., McDonald, K. (2008). Wnt Pathway Inhibitors Are Strongly Down-Regulated in Pituitary Tumors. Endocrinology, 149(3), 1235-1242. [More Information]

2007

  • Soon, P., Benn, D., Gill, A., Robinson, B., McDonald, K. (2007). Es07 microarray gene expression analysis of human adrenocortical tumours. ANZ Journal of Surgery, 77(Suppl.1), A22-A22. [More Information]
  • Parkinson, J., Wheeler, H., Clarkson, A., McKenzie, C., Biggs, M., Little, N., Cook, R., Messina, M., Robinson, B., McDonald, K. (2007). Variation of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma. Journal of Neuro-Oncology, DOI 10.1007/s11060-007-9486-0, 1-8. [More Information]

2004

  • McConchie, R., Nguyen, P., McDonald, K., Anwaral, B., Morris, S. (2004). Systemic Acquired Resistance As A Strategy For Postharvest Disease Management On Rockmelon (Cucumis Melo Var. Reticulatus). 5th ISHS Postharvest Symposium, : University of Melbourne.

2003

  • Perrone, S., McDonald, K., Sutherland, M., Guest, D. (2003). Superoxide release is necessary for phytoalexin accumulation in Nicotiana tabacum cells during the expression of cultivar-race and non-host resistance towards Phytophthora spp. Physiological and Molecular Plant Pathology, 62(3), 127-135.

2002

  • McDonald, K. (2002). Dynamic neural activity as chaotic itinerancy or heteroclinic cycles? Behavioral and Brain Sciences, , 1-3.
  • McDonald, K., Sutherland, M., Guest, D. (2002). Temporary hypoxia suppresses the oxidative burst and subsequent hypersensitive cell death in cells of tobacco and soybean challenged with zoospores of incompatible isolates of Phytophthora species. Physiological and Molecular Plant Pathology, 61(2), 133-140.

2001

  • Guest, D., Sutherland, A., McDonald, K. (2001). Sacrificial cell death in tobacco plants and isolation of an endogenous secondary cell death signal. In Feng Zhijie (Eds.), Plant Diseases and Their Control, (pp. Not known-Not known). China Agricultural Scientech Press.

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