Dr Kimberley Kaufman

BMedSc (Hons), PhD
Honorary Senior Research Fellow
Head of Brain Cancer Research. Chris O'Brien Lifehouse

Telephone +8514 0675

Website RPA Neuropathology Department
BrainStorm, Brain Cancer Research Charity
Level 7 - M02F Mallett Street Campus

Map

Biographical details

I am a biomedical scientist and cancer researcher passionate about improving the quality-of-life and survival rates for brain cancer patients.

Research interests

I'm particularly interested in understanding glioblastoma (GBM), the most common and aggressive brain tumour in adults. Treatment options for GBM patients are extremely limited, and after initial surgery and combined radio- and chemotherapy, tumours inevitably recur, at which point they are rapidly fatal.

My research group is conducting several studies aimed at understanding the roles of extracellular vesicles (EVs) in brain tumour biology. EVs, of which ‘exosomes’ are a subset, are stable, virus-sized particles released by all cell types. They contain an array of proteins, nucleic acids, lipids and other metabolites, which reflect the cell of origin but also display selective packaging of some molecules. Interest in the biological roles of EVs, predominantly as novel intercellular communicators, is expanding rapidly and includes direct roles in human pathology e.g., cancer, cardiovascular disease, neurodegeneration and metabolic disease.

My research utilises cutting-edge mass spectrometry with novel sample preparation procedures to resolve the molecular landscape of cancer. I am active in biomarker research, resolving novel protein markers by quantitative proteomic strategies using surgical tissues, aspirates and peripheral serums.

Teaching and supervision

Primary supervisor of the University Medal BMedSc (Hon I) recipient in 2016.

Supervision/co-supervision of three current PhD students, and have supervised two PhD students to completion.

Supervision of 15 BSc and BMedSc Honours students, all awarded Class I (2009-2016).

Supervision of undergraduate research students across multiple programs, including BMedSc and BSc summer scholarships, talented student program, advanced NEUR3903, MBBS and International interns (2009-2017)


Developed and delivered lectures in alcoholism, thiamine deficiency (NUTM3001), cancer and
 neuro-proteomics (BCHEM3092)

Current research students

Project title Research student
Towards a therapeutic vaccine for glioblastoma multiforme. Benjamin KONG

Current projects

  • The roles of extracellular vesicles in the glioblastoma tumour microenvironment
  • Extracellular vesicles as surrogates for non-invasive glioblastoma diagnosis and disease monitoring
  • Mechanisms of tumour recurrence and chemoresistance in glioma
  • Next generation molecular diagnostics for brain cancer

Associations

Cancer Institute NSW Neuro-Oncology Advisory Group

Brain Cancer Biobanking Australia

Experimental Neuropathology Affinity Group, Sydney Neuroscience Network

European Association for NeuroOncology

The Australian and New Zealand Society for Neuropathology

NHMRC Research Translation Faculty

European Association for Cancer Research

Australian Proteomics Society

Cancer Research Network Sydney University

Cancer Research NetworkTumour Microenvionment Special Interest Group

Cancer Research NetworkBrain Cancer Special Interest Group

Awards and honours

  • Outstanding Presentation in Cell Biology Sessionat USYD Cancer Research Network postgraduate and ECR Symposium (supervisor; 2017)
  • Top 5 presentation at Sydney Catalyst International Translational Research Symposium (2017)
  • Poster Prize at Lorne Extracellular Vesicles Symposium, Senior Author (2017)
  • Travel grant ($2500) to present at European Association for NeuroOncology meeting in Italy (2014)
  • Travel award ($3000) to present at Human Proteome Organisation World Congress in Spain (2014)
  • Award for outstanding abstract,S.Mactier, K.Kaufman et al., “Protein signatures correspond to survival outcomes of AJCC stage III melanoma patients”,Annual Paris Melanoma Conference (2014)
  • Fellowship travel grant ($2000) to attend the European Cancer Congress, Netherlands (2013)
  • Poster prize at Australasian Proteomics Symposium, Senior Author (2013)
  • Australasian Proteomics Society Early Postdoctoral Fellow Travel Award (2010)
  • Nerve Research Foundation ‘Bannigan Prize for the Best PhD in Neuroscience’ (2008).
  • Scholarship for internship at Brain Science Institute, RIKEN, Tokyo, Japan. Supervised by Molecular Psychiatrist, Dr Takeo Yoshikawa (2006).
  • Bercovici Prize for Excellence in Medical Research’ awarded to the postgraduate with the most outstanding publication at the University of Sydney (2006).
  • Summer Research Scholarship, Schizophrenia Research Institute (2003 – 2004)

In the media

https://www.9news.com.au/videos/blood-test-developed-to-diagnose-brain-cancer/cjpxq78de001s0hlhj5n0djry

https://www.facebook.com/brainstormresearch/

Manager of the RPA Hospital Neuropathology Tumour and Tissue Bank (NTTB) and Operations Manager of BrainStorm, brain cancer research charity of RPAH

Brain Cancer Biobanking Australia Rapid Autopsy working party

NHMRC project grant external reviewer

Peer reviews for Molecular and Cellular Proteomics, Journal of Proteome Research, Proteomics, Clinical Proteomics, PLoS ONE, Journal of Molecular and Genetic Medicine, Nanomedicine: NBM, Communications Biology

Themes

Molecular biology and biotechnology; Cancer; Genetics and genomics; Human health; Neurosciences and Mental Health

Selected grants

2018

  • Systemic effects of Glioblastoma multiforme (GBM) and GBM-released extracellular vesicles on immune repertories: implication for dendritic cell based vaccine therapy against GBM; Kim J, Clark G, Buckland M, Kaufman (nee Alexander) K, Kong B; University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding.

2014

  • Mechanisms of tumour recurrence and chemotherapy escape in glioblastoma multiforme; Kaufman (nee Alexander) K; Cancer Institute NSW/Early Career Fellowship.

2011

  • Surface Antigen Profiles of NeuralEctoderm Tumors:; Kaufman (nee Alexander) K; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Matsumoto, I., Kaufman (nee Alexander), K., Matsuda-Matsumoto, H., Kashem, M., Harper, C. (2008). Ethanol-Related Encephalopathies. In GianPietro Sechi (Eds.), Drug related Encephalopathies, (pp. 147-181). New York: Nova Science Publishers.

Journals

  • Hallal, S., Russell, B., Wei, H., Lee, M., Toon, C., Sy, J., Shivalingam, B., Buckland, M., Kaufman (nee Alexander), K. (2019). Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A (CCT6A) as a Potential Glioblastoma Biomarker with Prognostic Significance. Proteomics, 19. [More Information]
  • Hallal, S., Mallawaaratchy, D., Wei, H., Ebrahimkhani, S., Stringer, B., Day, B., Boyd, A., Guillemin, G., Buckland, M., Kaufman (nee Alexander), K. (2019). Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways. Molecular Neurobiology, In Press, 1-16. [More Information]
  • Azimi, A., Ali, M., Kaufman (nee Alexander), K., Mann, G., Fernandez Penas, P. (2019). Tape Stripped Stratum Corneum Samples Prove to be Suitable for Comprehensive Proteomic Investigation of Actinic Keratosis. Proteomics - Clinical Applications, In press, 1-8. [More Information]
  • Kim, J., Kong, B., Lo, T., Papadimitrous, M., Hsu, J., Fromm, P., Kaufman (nee Alexander), K., Buckland, M., Clark, G., Hart, D. (2018). A combinatory immunotherapy against brain tumour: blood dendritic cell based vaccine therapy with checkpoint inhibitor(s). Neuro-Oncology, 20(Suppl 6), vi94-vi95. [More Information]
  • Ebrahimkhani, S., Vafaee, F., Hallal, S., Wei, H., Lee, M., Young, P., Satgunaseelan, L., Beadnall, H., Barnett, M., Shivalingam, B., Buckland, M., Kaufman (nee Alexander), K., et al (2018). Deep sequencing of circulating exosomal microRNA allows non-invasive glioblastoma diagnosis. n p j Precision Oncology, 2, 1-9. [More Information]
  • Azimi, A., Kaufman (nee Alexander), K., Ali, M., Arthur, J., Kossard, S., Fernandez Penas, P. (2018). Differential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS. Journal of Dermatological Science, 91(1), 69-78. [More Information]
  • Mallawaaratchy, D., Hallal, S., Russell, B., Ly, L., Ebrahimkhani, S., Wei, H., Christopherson, R., Buckland, M., Kaufman (nee Alexander), K. (2017). Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Journal of Neuro-Oncology, 131(2), 233-244. [More Information]
  • Azimi, A., Kaufman (nee Alexander), K., Ali, M., Kossard, S., Fernandez Penas, P. (2016). In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue. Cancer Genomics & Proteomics, 13(6), 453-466. [More Information]
  • Azimi, A., Kaufman (nee Alexander), K., Ali, M., Kossard, S., Fernandez Penas, P. (2016). Label-free proteomic analysis of microdissected formalin-fixed and paraffin embedded cutaneous squamous cell carcinoma tissue. Australasian Journal of Dermatology, 57(S1), 49-49.
  • Huang, P., Mactier, S., Armacki, N., Best, O., Belov, L., Kaufman (nee Alexander), K., Pascovici, D., Mulligan, S., Christopherson, R. (2016). Protein profiles distinguish stable and progressive chronic lymphocytic leukemia. Leukemia & Lymphoma, 57(5), 1033-1043. [More Information]
  • Mallawaaratchy, D., Buckland, M., McDonald, K., Li, C., Ly, L., Sykes, E., Christopherson, R., Kaufman (nee Alexander), K. (2015). Membrane proteome analysis of glioblastoma cell invasion. Journal of Neuropathology and Experimental Neurology, 74(5), 425-441. [More Information]
  • Hare, N., Chan, B., Chan, E., Kaufman (nee Alexander), K., Britton, W., Saunders, B. (2015). Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15. Proteomics, 15(17), 3020-3029. [More Information]
  • Wilcox, P., Li, C., Lee, M., Shivalingam, B., Brennan, J., Suter, C., Kaufman, K., Lum, T., Buckland, M. (2015). Oligoastrocytomas: throwing the baby out with the bathwater? Acta Neuropathologica, 129(1), 147-149. [More Information]
  • Mulligan, S., Alomari, M., Kaufman (nee Alexander), K., Mactier, S., Best, G., Christopherson, R. (2015). Rituximab induces major changes in the surface proteome of lipid rafts on human MEC1 chronic lymphocytic leukemia cells. Leukemia & Lymphoma, 56(Sup1), 9-9.
  • Kaufman (nee Alexander), K., Mactier, S., Christopherson, R. (2015). Surface Antigen Profiling of Surgical Melanoma Specimens. Methods in Molecular Biology, , 1-9. [More Information]
  • Zhou, J., Belov, L., Chapuis, P., Chan, C., Armstrong, N., Kaufman (nee Alexander), K., Solomon, M., Clarke, S., Christopherson, R. (2015). Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories. Journal of Immunological Methods, 416, 59-68. [More Information]
  • Kaufman, K., Jenkins, Y., Alomari, M., Mirzaei, M., Best, O., Pascovici, D., Mactier, S., Mulligan, S., Haynes, P., Christopherson, R. (2015). The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia. Oncotarget, 6(38), 40981-40997. [More Information]
  • Kaufman (nee Alexander), K., Ly, L., McKay, M., Mallawaaratchy, D., Mactier, S., Crossett, B., Molloy, M., Buckland, M., McDonald, K., Christopherson, R. (2014). Comprehensive proteomic profiling of bevacizumab-resistant glioblastoma multiforme. Neuro-Oncology, 16(Suppl 2), ii98-ii98.
  • Mallawaaratchy, D., McDonald, K., Sykes, E., Buckland, M., Christopherson, R., Kaufman (nee Alexander), K. (2014). Novel proteins associated with invadopodia structures in glioblastoma. Neuro-Oncology, 16(Suppl 2), ii100-ii100. [More Information]
  • Alomari, M., Mactier, S., Kaufman (nee Alexander), K., Best, O., Mulligan, S., Christopherson, R. (2014). Profiling the lipid raft proteome from human MEC1 chronic lymphocytic Leukemia Cells. Journal of Proteomics & Bioinformatics, S7, 1-10. [More Information]
  • Mactier, S., Kaufman (nee Alexander), K., Wang, P., Crossett, B., Pupo, G., Kohnke, P., Thompson, J., Scolyer, R., Yang, J., Mann, G., Christopherson, R. (2014). Protein signatures correspond to survival outcomes of AJCC stage III melanoma patients. Pigment Cell & Melanoma Research, 27(6), 1106-1116. [More Information]
  • Kaufman (nee Alexander), K., Mactier, S., Armstrong, N., Mallawaaratchy, D., Byrne, S., Haydu, L., Jakrot, V., Thompson, J., Mann, G., Scolyer, R., Christopherson, R. (2014). Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients. Clinical and Experimental Metastasis, 31, 407-421. [More Information]
  • Che, Y., Best, G., Zhong, L., Kaufman (nee Alexander), K., Mactier, S., Raftery, M., Graves, L., Mulligan, S., Christopherson, R. (2013). Hsp90 Inhibitor SNX-7081 Dysregulates Proteins Involved with DNA Repair and Replication and the Cell Cycle in Human Chronic Lymphocytic Leukemia (CLL) Cells. Journal of Proteome Research, 12(4), 1710-1722. [More Information]
  • Mactier, S., Kaufman (nee Alexander), K., Wang, P., Crossett, B., Yang, E., Scolyer, R., Yang, J., Mann, G., Christopherson, R. (2013). Identification of markers prognostic of survival in lymph node metastases from stage III melanoma patients. European Journal of Cancer, 49(Suppl 2), S874-S874.
  • Mallawaaratchy, D., Christopherson, R., Kaufman (nee Alexander), K. (2013). Membrane proteome analysis of invasive human glioblastoma multiforme. European Journal of Cancer, 49(Suppl 2), S132-S133.
  • Mallawaaratchy, D., Mactier, S., Kaufman (nee Alexander), K., Blomfield, S., Christopherson, R. (2012). The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells. Journal of Proteomics, 75(5), 1590-1599. [More Information]
  • Heath, E., Kaufman (nee Alexander), K., Christopherson, R. (2011). B-RAF: A Contributor to the Melanoma Phenotype. International Journal of Biochemistry and Cell Biology, 43(1), 29-32. [More Information]
  • Zahr, N., Kaufman (nee Alexander), K., Harper, C. (2011). Clinical and pathological features of alcohol-related brain damage. Nature Reviews Neurology, 7(5), 284-294. [More Information]
  • Kaufman (nee Alexander), K., Belov, L., Huang, P., Mactier, S., Scolyer, R., Mann, G., Christopherson, R. (2010). An extended antibody microarray for surface profiling metastatic melanoma. Journal of Immunological Methods, 358(40210 (1-2)), 23-34. [More Information]
  • Kaufman (nee Alexander), K., Harper, C. (2009). Transketolase: Observations in alcohol-related brain damage research. International Journal of Biochemistry and Cell Biology, 41(4), 717-720. [More Information]
  • Harper, C., Kaufman (nee Alexander), K., Kashem, M., Matsumoto, I., He, X., Pfefferbaum, A., Sullivan, E. (2008). Thiamine deficiency is a critical factor in alcohol-related brain damage � new experimental structural and human proteomics data. Alcoholism: Clinical and Experimental Research, 32(Suppl 1), 300A-300A.
  • Kaufman (nee Alexander), K., Cordwell, S., Harper, C., Matsumoto, I. (2007). A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Proteomics - Clinical Applications, 1(1), 62-72. [More Information]
  • Kaufman (nee Alexander), K., Kashem, M., Harper, C., Matsumoto, I. (2007). Alcohol-related brain damage: Proteomics investigations using postmortem human brain tissue. Neuropathology, 27(2), 175-175.
  • Kaufman (nee Alexander), K., Harper, C., Wilce, P., Matsumoto, I. (2007). Cerebellar Vermis Proteome of Chronic Alcoholic Individuals. Alcoholism: Clinical and Experimental Research, 31(8), 1286-1296. [More Information]
  • Matsumoto, I., Kaufman (nee Alexander), K., Iwazaki, T., Kashem, M., Matsuda-Matsumoto, H. (2007). CNS proteomes in alcohol and drug abuse and dependence. Expert Review of Proteomics, 4(4), 539-552. [More Information]
  • Kaufman (nee Alexander), K., Kashem, M., Harper, C., Sheedy, D. (2007). Proteome analyses of human brain regions sensitive to alcohol-induced brain damage. Alcoholism: Clinical and Experimental Research, 31(6), 31A-31A.
  • Kaufman (nee Alexander), K., Kashem, M., Harper, C., Matsumoto, I. (2007). Proteome analyses of human brain regions sensitive to alcohol-induced damage. Neuropathology, 27(2), 182-182.
  • Kaufman (nee Alexander), K., Dedova, I., Harper, C., Matsumoto, I. (2007). Proteome analysis of the dorsolateral prefrontal region from healthy individuals. Neurochemistry International, 51(6-7), 433-439. [More Information]
  • Matsumoto, I., Kaufman (nee Alexander), K., Harper, C. (2006). Alcohol-induced brain damage: Proteomics on postmortem human brain. Alcoholism: Clinical and Experimental Research, 30(Sup.2), 85A-85A.
  • Kaufman (nee Alexander), K., James, G., Sheedy, D., Harper, C., Matsumoto, I. (2006). Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Molecular Psychiatry, 11(1), 56-65. [More Information]

Conferences

  • Kaufman (nee Alexander), K., Harper, C., Matsumoto, I. (2006). A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Matsumoto, I., Kaufman (nee Alexander), K. (2006). Alcohol-specific cascades underlying alcohol-induced prefrontal cortex damage: Insight proteomics studies. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.

2019

  • Hallal, S., Russell, B., Wei, H., Lee, M., Toon, C., Sy, J., Shivalingam, B., Buckland, M., Kaufman (nee Alexander), K. (2019). Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A (CCT6A) as a Potential Glioblastoma Biomarker with Prognostic Significance. Proteomics, 19. [More Information]
  • Hallal, S., Mallawaaratchy, D., Wei, H., Ebrahimkhani, S., Stringer, B., Day, B., Boyd, A., Guillemin, G., Buckland, M., Kaufman (nee Alexander), K. (2019). Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways. Molecular Neurobiology, In Press, 1-16. [More Information]
  • Azimi, A., Ali, M., Kaufman (nee Alexander), K., Mann, G., Fernandez Penas, P. (2019). Tape Stripped Stratum Corneum Samples Prove to be Suitable for Comprehensive Proteomic Investigation of Actinic Keratosis. Proteomics - Clinical Applications, In press, 1-8. [More Information]

2018

  • Kim, J., Kong, B., Lo, T., Papadimitrous, M., Hsu, J., Fromm, P., Kaufman (nee Alexander), K., Buckland, M., Clark, G., Hart, D. (2018). A combinatory immunotherapy against brain tumour: blood dendritic cell based vaccine therapy with checkpoint inhibitor(s). Neuro-Oncology, 20(Suppl 6), vi94-vi95. [More Information]
  • Ebrahimkhani, S., Vafaee, F., Hallal, S., Wei, H., Lee, M., Young, P., Satgunaseelan, L., Beadnall, H., Barnett, M., Shivalingam, B., Buckland, M., Kaufman (nee Alexander), K., et al (2018). Deep sequencing of circulating exosomal microRNA allows non-invasive glioblastoma diagnosis. n p j Precision Oncology, 2, 1-9. [More Information]
  • Azimi, A., Kaufman (nee Alexander), K., Ali, M., Arthur, J., Kossard, S., Fernandez Penas, P. (2018). Differential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS. Journal of Dermatological Science, 91(1), 69-78. [More Information]

2017

  • Mallawaaratchy, D., Hallal, S., Russell, B., Ly, L., Ebrahimkhani, S., Wei, H., Christopherson, R., Buckland, M., Kaufman (nee Alexander), K. (2017). Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Journal of Neuro-Oncology, 131(2), 233-244. [More Information]

2016

  • Azimi, A., Kaufman (nee Alexander), K., Ali, M., Kossard, S., Fernandez Penas, P. (2016). In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue. Cancer Genomics & Proteomics, 13(6), 453-466. [More Information]
  • Azimi, A., Kaufman (nee Alexander), K., Ali, M., Kossard, S., Fernandez Penas, P. (2016). Label-free proteomic analysis of microdissected formalin-fixed and paraffin embedded cutaneous squamous cell carcinoma tissue. Australasian Journal of Dermatology, 57(S1), 49-49.
  • Huang, P., Mactier, S., Armacki, N., Best, O., Belov, L., Kaufman (nee Alexander), K., Pascovici, D., Mulligan, S., Christopherson, R. (2016). Protein profiles distinguish stable and progressive chronic lymphocytic leukemia. Leukemia & Lymphoma, 57(5), 1033-1043. [More Information]

2015

  • Mallawaaratchy, D., Buckland, M., McDonald, K., Li, C., Ly, L., Sykes, E., Christopherson, R., Kaufman (nee Alexander), K. (2015). Membrane proteome analysis of glioblastoma cell invasion. Journal of Neuropathology and Experimental Neurology, 74(5), 425-441. [More Information]
  • Hare, N., Chan, B., Chan, E., Kaufman (nee Alexander), K., Britton, W., Saunders, B. (2015). Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15. Proteomics, 15(17), 3020-3029. [More Information]
  • Wilcox, P., Li, C., Lee, M., Shivalingam, B., Brennan, J., Suter, C., Kaufman, K., Lum, T., Buckland, M. (2015). Oligoastrocytomas: throwing the baby out with the bathwater? Acta Neuropathologica, 129(1), 147-149. [More Information]
  • Mulligan, S., Alomari, M., Kaufman (nee Alexander), K., Mactier, S., Best, G., Christopherson, R. (2015). Rituximab induces major changes in the surface proteome of lipid rafts on human MEC1 chronic lymphocytic leukemia cells. Leukemia & Lymphoma, 56(Sup1), 9-9.
  • Kaufman (nee Alexander), K., Mactier, S., Christopherson, R. (2015). Surface Antigen Profiling of Surgical Melanoma Specimens. Methods in Molecular Biology, , 1-9. [More Information]
  • Zhou, J., Belov, L., Chapuis, P., Chan, C., Armstrong, N., Kaufman (nee Alexander), K., Solomon, M., Clarke, S., Christopherson, R. (2015). Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories. Journal of Immunological Methods, 416, 59-68. [More Information]
  • Kaufman, K., Jenkins, Y., Alomari, M., Mirzaei, M., Best, O., Pascovici, D., Mactier, S., Mulligan, S., Haynes, P., Christopherson, R. (2015). The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia. Oncotarget, 6(38), 40981-40997. [More Information]

2014

  • Kaufman (nee Alexander), K., Ly, L., McKay, M., Mallawaaratchy, D., Mactier, S., Crossett, B., Molloy, M., Buckland, M., McDonald, K., Christopherson, R. (2014). Comprehensive proteomic profiling of bevacizumab-resistant glioblastoma multiforme. Neuro-Oncology, 16(Suppl 2), ii98-ii98.
  • Mallawaaratchy, D., McDonald, K., Sykes, E., Buckland, M., Christopherson, R., Kaufman (nee Alexander), K. (2014). Novel proteins associated with invadopodia structures in glioblastoma. Neuro-Oncology, 16(Suppl 2), ii100-ii100. [More Information]
  • Alomari, M., Mactier, S., Kaufman (nee Alexander), K., Best, O., Mulligan, S., Christopherson, R. (2014). Profiling the lipid raft proteome from human MEC1 chronic lymphocytic Leukemia Cells. Journal of Proteomics & Bioinformatics, S7, 1-10. [More Information]
  • Mactier, S., Kaufman (nee Alexander), K., Wang, P., Crossett, B., Pupo, G., Kohnke, P., Thompson, J., Scolyer, R., Yang, J., Mann, G., Christopherson, R. (2014). Protein signatures correspond to survival outcomes of AJCC stage III melanoma patients. Pigment Cell & Melanoma Research, 27(6), 1106-1116. [More Information]
  • Kaufman (nee Alexander), K., Mactier, S., Armstrong, N., Mallawaaratchy, D., Byrne, S., Haydu, L., Jakrot, V., Thompson, J., Mann, G., Scolyer, R., Christopherson, R. (2014). Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients. Clinical and Experimental Metastasis, 31, 407-421. [More Information]

2013

  • Che, Y., Best, G., Zhong, L., Kaufman (nee Alexander), K., Mactier, S., Raftery, M., Graves, L., Mulligan, S., Christopherson, R. (2013). Hsp90 Inhibitor SNX-7081 Dysregulates Proteins Involved with DNA Repair and Replication and the Cell Cycle in Human Chronic Lymphocytic Leukemia (CLL) Cells. Journal of Proteome Research, 12(4), 1710-1722. [More Information]
  • Mactier, S., Kaufman (nee Alexander), K., Wang, P., Crossett, B., Yang, E., Scolyer, R., Yang, J., Mann, G., Christopherson, R. (2013). Identification of markers prognostic of survival in lymph node metastases from stage III melanoma patients. European Journal of Cancer, 49(Suppl 2), S874-S874.
  • Mallawaaratchy, D., Christopherson, R., Kaufman (nee Alexander), K. (2013). Membrane proteome analysis of invasive human glioblastoma multiforme. European Journal of Cancer, 49(Suppl 2), S132-S133.

2012

  • Mallawaaratchy, D., Mactier, S., Kaufman (nee Alexander), K., Blomfield, S., Christopherson, R. (2012). The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells. Journal of Proteomics, 75(5), 1590-1599. [More Information]

2011

  • Heath, E., Kaufman (nee Alexander), K., Christopherson, R. (2011). B-RAF: A Contributor to the Melanoma Phenotype. International Journal of Biochemistry and Cell Biology, 43(1), 29-32. [More Information]
  • Zahr, N., Kaufman (nee Alexander), K., Harper, C. (2011). Clinical and pathological features of alcohol-related brain damage. Nature Reviews Neurology, 7(5), 284-294. [More Information]

2010

  • Kaufman (nee Alexander), K., Belov, L., Huang, P., Mactier, S., Scolyer, R., Mann, G., Christopherson, R. (2010). An extended antibody microarray for surface profiling metastatic melanoma. Journal of Immunological Methods, 358(40210 (1-2)), 23-34. [More Information]

2009

  • Kaufman (nee Alexander), K., Harper, C. (2009). Transketolase: Observations in alcohol-related brain damage research. International Journal of Biochemistry and Cell Biology, 41(4), 717-720. [More Information]

2008

  • Matsumoto, I., Kaufman (nee Alexander), K., Matsuda-Matsumoto, H., Kashem, M., Harper, C. (2008). Ethanol-Related Encephalopathies. In GianPietro Sechi (Eds.), Drug related Encephalopathies, (pp. 147-181). New York: Nova Science Publishers.
  • Harper, C., Kaufman (nee Alexander), K., Kashem, M., Matsumoto, I., He, X., Pfefferbaum, A., Sullivan, E. (2008). Thiamine deficiency is a critical factor in alcohol-related brain damage � new experimental structural and human proteomics data. Alcoholism: Clinical and Experimental Research, 32(Suppl 1), 300A-300A.

2007

  • Kaufman (nee Alexander), K., Cordwell, S., Harper, C., Matsumoto, I. (2007). A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Proteomics - Clinical Applications, 1(1), 62-72. [More Information]
  • Kaufman (nee Alexander), K., Kashem, M., Harper, C., Matsumoto, I. (2007). Alcohol-related brain damage: Proteomics investigations using postmortem human brain tissue. Neuropathology, 27(2), 175-175.
  • Kaufman (nee Alexander), K., Harper, C., Wilce, P., Matsumoto, I. (2007). Cerebellar Vermis Proteome of Chronic Alcoholic Individuals. Alcoholism: Clinical and Experimental Research, 31(8), 1286-1296. [More Information]
  • Matsumoto, I., Kaufman (nee Alexander), K., Iwazaki, T., Kashem, M., Matsuda-Matsumoto, H. (2007). CNS proteomes in alcohol and drug abuse and dependence. Expert Review of Proteomics, 4(4), 539-552. [More Information]
  • Kaufman (nee Alexander), K., Kashem, M., Harper, C., Sheedy, D. (2007). Proteome analyses of human brain regions sensitive to alcohol-induced brain damage. Alcoholism: Clinical and Experimental Research, 31(6), 31A-31A.
  • Kaufman (nee Alexander), K., Kashem, M., Harper, C., Matsumoto, I. (2007). Proteome analyses of human brain regions sensitive to alcohol-induced damage. Neuropathology, 27(2), 182-182.
  • Kaufman (nee Alexander), K., Dedova, I., Harper, C., Matsumoto, I. (2007). Proteome analysis of the dorsolateral prefrontal region from healthy individuals. Neurochemistry International, 51(6-7), 433-439. [More Information]

2006

  • Kaufman (nee Alexander), K., Harper, C., Matsumoto, I. (2006). A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Matsumoto, I., Kaufman (nee Alexander), K., Harper, C. (2006). Alcohol-induced brain damage: Proteomics on postmortem human brain. Alcoholism: Clinical and Experimental Research, 30(Sup.2), 85A-85A.
  • Matsumoto, I., Kaufman (nee Alexander), K. (2006). Alcohol-specific cascades underlying alcohol-induced prefrontal cortex damage: Insight proteomics studies. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Kaufman (nee Alexander), K., James, G., Sheedy, D., Harper, C., Matsumoto, I. (2006). Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Molecular Psychiatry, 11(1), 56-65. [More Information]

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