Associate Professor Lars Ittner

Honorary Associate Professor
Brain & Mind Research Institute, Sydney Medical School

Telephone +61 2 9351 0845
Fax +61 2 9351 0731

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Teaching and supervision

Neuroanatomy

Selected grants

2013

  • Establishing next-generation transgenic mouse models of Alzheimer's disease; Ittner L, Van Eersel J, Ke Y; J.O. & J.R. Wicking Trust & Mason Foundation/Alzheimer's disease and Chronic Fatigue Syndrome (Wicking Trust & Mason Foundation).
  • Physiology of tau - a novel role in scaffolding and intracellular distribution; Ittner L; Australian Research Council (ARC)/Discovery Projects (DP).

2012

  • Validation of ATP13a2/PARK9 as a target to reduce neurodegeneration induced by alpha-synuclein; Cooper A, Karl T, Ittner L; Michael J Fox Foundation for Parkinsons Research/Research Support.
  • The role of tau in excitotoxicity in Alzheimers disease; Ittner L; Alzheimers Association (USA)/New Investigator Research Grant.
  • NOVEL MECHANISMS UNDERLYING THE SPREADING OF TAU PATHOLOGY IN ALZHEIMERS DISEASE AND OTHER TAUOPATHIES; Ittner L, Kril J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The IntelliCage system; Ittner L; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Selective vunerability in alzheimers disease and related disorders: Mechanism of tau pathology; Goetz J, Ittner L; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Selective vunerability in alzheimers disease and related disorders: Mechanism of tau pathology; Goetz J, Ittner L; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Senior Research Fellowship B; Ittner L; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.

2010

  • The translocator protein (TSPO) as a novel target for the treatment of Alzheimer's Disease; Ittner L, Kassiou M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Role of diabetes and obesity in transgenic mouse model of Alzheimer's disease; Ittner L; Diabetes Australia Research Trust/Research Grants.
  • Package for biolistic delivery; Goetz J, Carter D, Ittner L, Nicholas H, Schonrock N, Ke Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Neuronal functions of the microtubule-associated protein tau in development and ageing; Goetz J, Ittner L; Australian Research Council (ARC)/Discovery Projects (DP).
  • Biological functions of the TAR DNA binding protein 43; Ittner L, Goetz J, Haass N; Australian Research Council (ARC)/Discovery Projects (DP).

2009

  • Pathogenesis of Alzheimers Disease and related Disorders: Mechanism of Tau Pathology; Goetz J, Ittner L; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Pathogenic mechanisms common to all subtypes of frontotemporal dementia; Kril J, Ittner L, Goetz J, Halliday G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Hidex Chameleon V Multi-Technology plate reader; Ittner L, Goetz J, MacDonald C, Kassiou M, Connor M, Holsinger D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Development of highthroughput screening assays for application in neuroscience and neuropathology; Ittner L; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2008

  • Comparative analysis of novel transgenic mouse models formbrain and islet amyloidoses; Goetz J, Ittner L; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Research Infrastructure (Major Equipment) Scheme 2008; Ittner L, Goetz J, Christie M, Bennett M, Kassiou M, Connor M, Holsinger D, Bagley E; Faculty of Medicine/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • Expression analysis in brain cells; Ittner L, Strappe P, Schonrock N, Goetz J, Kril J; University of Sydney/Major Equipment.
  • Novel functions of the microtubule-associated protein tau in signaling and transport: physiological and pathological implications; Goetz J, Ittner L; Australian Research Council (ARC)/Discovery Projects (DP).

2006

  • University of Sydney - Postdoctural Fellowship; Ittner L; University of Sydney/PDF.

Selected publications

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Book Chapters

  • Goetz, J., Ittner, L., Goetz, N., Lam, H., Nicholas, H. (2011). Invertebrate and Vertebrate Models of Tauopathies. In J. Avila, J. J. Lucas & F. Hernandez (Eds.), Animal Models for Neurodegenerative Disease, (pp. 69-85). Cambridge, UK: RSC Publishing.
  • Ittner, L., David, D., Goetz, J. (2006). Impact of beta-amyloid on the tau pathology in tau transgenic mouse and tissue culture models. In Colin J Barrow, David H Small (Eds.), Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research, (pp. 198-215). United Kingdom: Springer UK.

Journals

  • Gladbach, A., Van Eersel, J., Bi, M., Ke, Y., Ittner, L. (2014). ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke. Journal of Neural Transmission, 121(5), 543-547. [More Information]
  • Delerue, F., White, M., Ittner, L. (2014). Inducible, tightly regulated and non-leaky neuronal gene expression in mice. Transgenic Research, 23(2), 225-233. [More Information]
  • Nilsen, L., Rae, C., Ittner, L., Goetz, J., Sonnewald, U. (2013). Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of Cerebral Blood Flow and Metabolism, 33(5), 684-691. [More Information]
  • Ong, W., Tanaka, K., Dawe, G., Ittner, L., Farooqui, A. (2013). Slow Excitotoxicity in Alzheimer's Disease. Journal of Alzheimer's Disease, 35(4), 643-668. [More Information]
  • Gotz, J., Matamales, M., Gotz, N., Ittner, L., Eckert, A. (2012). Alzheimer's disease models and functional genomics-How many needles are there in the haystack? Frontiers in Physiology, 3, 1-14. [More Information]
  • Scarf, A., Luus, C., Da Pozzo, E., Selleri, S., Guarino, C., Martini, C., Ittner, L., Kassiou, M. (2012). Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa). Current Molecular Medicine, 12(4), 488-493. [More Information]
  • Ke, Y., Suchowerska, A., Hoven, J., De Silva, D., Wu, C., Van Eersel, J., Ittner, A., Ittner, L. (2012). Lessons from Tau-Deficient Mice. International Journal of Alzheimer's Disease, 2012 (Article ID 873270), 1-8. [More Information]
  • Schonrock, N., Sanchez Matamales, M., Ittner, L., Goetz, J. (2012). MicroRNA networks surrounding APP and amyloid-B metabolism - Implications for Alzheimer's disease. Experimental Neurology, 235(2), 447-454. [More Information]
  • Rosenmann, H., Blum, D., Kayed, R., Ittner, L. (2012). Tau protein: function and pathology. International Journal of Alzheimer's Disease, 2012, 707482-707482. [More Information]
  • Ke, Y., Dramiga, J., Schutz, U., Kril, J., Ittner, L., Schroder, H., Goetz, J. (2012). Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease. PLoS One, 7(4), 1-8. [More Information]
  • Goetz, J., Ittner, A., Ittner, L. (2012). Tau-targeted treatment strategies in Alzheimer's disease. British Journal of Pharmacology, 165(5), 1246-1259. [More Information]
  • Ittner, L., Goetz, J. (2011). Amyloid-beta and tau - a toxic pas de deux in Alzheimer's disease. Nature Reviews. Neuroscience, 12(2), 67-72. [More Information]
  • Ittner, A., Ke, Y., Van Eersel, J., Gladbach, A., Goetz, J., Ittner, L. (2011). Brief update on different roles of tau in neurodegeneration. IUBMB Life, 63(7), 495-502. [More Information]
  • Van Eersel, J., Ke, Y., Gladbach, A., Bi, M., Goetz, J., Kril, J., Ittner, L. (2011). Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons. PLoS One, 6(7), 1-13. [More Information]
  • Liu, X., Dobbie, M., Tunningley, R., Whittle, B., Zhang, Y., Ittner, L., Goetz, J. (2011). ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice. Journal of Biomedicine and Biotechnology, 2011 (Article Number 130947), 1-11. [More Information]
  • Lim, Y., Grimm, A., Giese, M., Mensah-Nyagan, A., Villafranca, J., Ittner, L., Eckert, A., Goetz, J. (2011). Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS One, 6(12), e28887 - 1-e28887 - 12. [More Information]
  • Goetz, J., Eckert, A., Sanchez Matamales, M., Ittner, L., Liu, X. (2011). Modes of Abeta toxicity in Alzheimer's disease. Cellular and Molecular Life Sciences, 68(20), 3359-3375. [More Information]
  • Bi, M., Ittner, A., Ke, Y., Goetz, J., Ittner, L. (2011). Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice. PLoS One, 6(12), e26860-(7pp). [More Information]
  • Lim, Y., Rhein, V., Baysang, G., Meier, F., Poljak, A., Raftery, M., Guilhaus, M., Ittner, L., Eckert, A., Goetz, J. (2010). Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics, 10(8), 1621-1633. [More Information]
  • Goetz, J., Gladbach, A., Pennanen, L., Van Eersel, J., Schild, A., David, D., Ittner, L. (2010). Animal models reveal role for tau phosphorylation in human disease. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1802 (10), 860-871. [More Information]
  • Ittner, L., Ke, Y., Delerue, F., Bi, M., Gladbach, A., Van Eersel, J., Wolfing, H., Chieng, B., Christie, M., Napier, I., Goetz, J., et al (2010). Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell, 142(3), 387-397. [More Information]
  • Goetz, J., Lim, Y., Ke, Y., Eckert, A., Ittner, L. (2010). Dissecting Toxicity of Tau and beta-Amyloid. Neurodegenerative Diseases, 7(1), 10-12. [More Information]
  • Krupka, N., Strappe, P., Goetz, J., Ittner, L. (2010). Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid, 63(3), 155-160. [More Information]
  • Schonrock, N., Ke, Y., Humphreys, D., Staufenbiel, M., Ittner, L., Preiss, T., Goetz, J. (2010). Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-beta. PLoS One, 5(6), e11070-1-e11070-11. [More Information]
  • Van Eersel, J., Ke, Y., Liu, X., Delerue, F., Kril, J., Goetz, J., Ittner, L. (2010). Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 107(31), 13888-13893. [More Information]
  • Goetz, J., Schonrock, N., Vissel, B., Ittner, L. (2009). Alzheimer’s Disease Selective Vulnerability and Modeling in Transgenic Mice. Journal of Alzheimer's Disease, 18(2), 243-251. [More Information]
  • Wiesner, A., Rhein, V., Song, X., Ittner, L., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Drose, S., Brandt, U., Goetz, J., et al (2009). Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 106(47), 20057-20062. [More Information]
  • Goetz, J., Ittner, L., Lim, Y. (2009). Common features between diabetes mellitus and Alzheimer's disease. Cellular and Molecular Life Sciences, 66(8), 1321-1325. [More Information]
  • Ke, Y., Delerue, F., Gladbach, A., Goetz, J., Ittner, L. (2009). Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease. PLoS One, 4(11), e7917 - 1-e7917 - 7. [More Information]
  • Ittner, L., Ke, Y., Goetz, J. (2009). Phosphorylated tau interacts with c-JUN N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer''s disease. Journal of Biological Chemistry, 284(31), 20909-20916. [More Information]
  • Van Eersel, J., Bi, M., Ke, Y., Hodges, J., Xuereb, J., Gregory, G., Halliday, G., Goetz, J., Kril, J., Ittner, L. (2009). Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of Neural Transmission, 116(10), 1243-1251. [More Information]
  • Fath, T., Ke, Y., Gunning, P., Goetz, J., Ittner, L. (2009). Primary support cultures of hippocampal and substantia nigra neurons. Nature Protocols (Print), 4(1), 78-85. [More Information]
  • Goetz, J., Ittner, L., Lim, Y. (2009). Response to the comment 'Iron, type 2 diabetes mellitus, and Alzheimer's disease' to our Visions and Reflections article 'Common features between diabetes mellitus and Alzheimer's disease'. Cellular and Molecular Life Sciences, 66(17), 2945-2945. [More Information]
  • Deters, N., Ittner, L., Goetz, J. (2009). Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and Biophysical Research Communications, 379(2), 400-405. [More Information]
  • Scarf, A., Ittner, L., Kassiou, M. (2009). The translocator protein (18 kDa): Central nervous system disease and drug design. Journal of Medicinal Chemistry, 52(3), 581-592. [More Information]
  • Goetz, J., Ittner, L., Schonrock, N., Cappai, R. (2008). An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatric Disease and Treatment, 4(6), 1033-1042. [More Information]
  • Goetz, J., Ittner, L. (2008). Animal models of Alzheimer's disease and frontotemporal dementia. Nature Reviews. Neuroscience, 9(7), 532-544. [More Information]
  • Falk, S., Wurdak, H., Ittner, L., Ille, F., Sumara, G., Schmid, M., Draganova, K., Lang, K., Paratore, C., Leveen, P., et al (2008). Brain Area-Specific Effect of TGF-β Signaling on Wnt-Dependent Neural Stem Cell Expansion. Cell Stem Cell, 2(5), 472-483. [More Information]
  • Deters, N., Ittner, L., Goetz, J. (2008). Divergent phosphorylation pattern of tau in P301L tau transgenic mice. European Journal of Neuroscience, 28(1), 137-147. [More Information]
  • Goetz, J., David, D., Hoerndli, F., Ke, Y., Schonrock, N., Wiesner, A., Fath, T., Bokhari, Y., Lim, Y., Deters, N., Ittner, L. (2008). Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neurodegenerative Diseases, 5, 179-181. [More Information]
  • Lim, Y., Ittner, L., Lim, Y., Goetz, J. (2008). Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS Letters, 582(15), 2188-2194. [More Information]
  • Goetz, J., Ittner, L., Fandrich, M., Schonrock, N. (2008). Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods? Journal of Alzheimer's Disease, 14(4), 423-429. [More Information]
  • Ittner, L., Fath, T., Ke, Y., Bi, M., Van Eersel, J., Li, K., Gunning, P., Goetz, J. (2008). Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 105(41), 15997-6002. [More Information]
  • Ittner, L., Schwerdtfeger, K., Kunz, T., Muff, R., Husmann, K., Grimm, C., Hafezi, F., Lang, K., Kurrer, M., Born, W., Goetz, J., et al (2008). Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clinical Science, 114(1), 49-58. [More Information]
  • Goetz, J., Deters, N., Doldissen, A., Bokhari, Y., Ke, Y., Wiesner, A., Schonrock, N., Ittner, L. (2007). A decade of tau transgenic animal models and beyond. Brain Pathology, 17(1), 91-103. [More Information]
  • Kunz, T., Scott, M., Ittner, L., Fischer, J., Born, W., Vogel, J. (2007). Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity. American Journal of Physiology: Heart and Circulatory Physiology, 293(4), H2155-H2160. [More Information]
  • Stanescu, D., Iseli, H., Schwerdtfeger, K., Ittner, L., Reme, C., Hafezi, F. (2007). Continuous expression of the homeobox gene Pax6 in the ageing human retina. Eye, 21(1), 90-93. [More Information]
  • Kunz, T., Mueller-Steiner, S., Schwerdtfeger, K., Kleinert, P., Troxler, H., Kelm, J., Ittner, L., Fischer, J., Born, W. (2007). Interaction of receptor-activity-modifying protein1 with tubulin. BBA - Bioenergetics, 1770 (8), 1145-1150. [More Information]
  • Ittner, L., Goetz, J. (2007). Pronuclear injection for the production of transgenic mice. Nature Protocols (Print), 2(5), 1206-1215. [More Information]
  • Ille, F., Atanasoski, S., Falk, S., Ittner, L., Maerki, D., Buechmann-Moller, S., Wurdak, H., Suter, U., Taketo, M., Sommer, L. (2007). Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord. Developmental Biology, 304(1), 394-408. [More Information]
  • Schild, A., Schmidt, K., Lim, Y., Ke, Y., Ittner, L., Hemmings, B., Goetz, J. (2006). Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. International Journal of Developmental Neuroscience, 24(7), 437-443. [More Information]
  • Schild, A., Ittner, L., Goetz, J. (2006). Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochemical and Biophysical Research Communications, 343(4), 1171-1178. [More Information]
  • Goetz, J., Ittner, L., Schonrock, N. (2006). Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy? Medical Journal of Australia, 185(7), 381-384. [More Information]
  • David, D., Ittner, L., Gehrig, P., Nergenau, D., Shepherd, C., Halliday, G., Goetz, J. (2006). beta-Amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics, 6(24), 6566-6577. [More Information]
  • Wurdak, H., Ittner, L., Sommer, L. (2006). DiGeorge syndrome and pharyngeal apparatus development. BioEssays, 28(11), 1078-1086. [More Information]
  • Goetz, J., Ittner, L., Kins, S. (2006). Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease? Journal of Neurochemistry, 98(4), 993-1006. [More Information]
  • Tam, C., Husmann, K., Clark, N., Clark, J., Lazar, Z., Ittner, L., Goetz, J., Douglas, G., Grant, A., Sugden, D., et al (2006). Enhanced Vascular Responses to Adrenomedullin in Mice Overexpressing Receptor-Activity-Modifying Protein 2. Circulation Research, 98(2), 262-270. [More Information]
  • Schild, A., Isenmann, S., Tanimoto, N., Tonagel, F., Seeliger, M., Ittner, L., Kretz, A., Ogris, E., Goetz, J. (2006). Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice. Mechanisms of Development, 123(5), 362-371. [More Information]
  • Kelm, J., Ittner, L., Born, W., Djonov, V., Fussenegger, M. (2006). Self-assembly of sensory neurons into ganglia-like microtissues. Journal of Biotechnology, 121(1), 86-101. [More Information]
  • Kelm, J., Djonov, V., Hoerstrup, S., Guenter, C., Ittner, L., Greve, F., Hierlemann, A., Sanchez-Bustamante, C., Perriard, J., Ehler, E., et al (2006). Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats. Tissue Engineering. Part A, 12(9), 2541-2553. [More Information]
  • Ittner, L., Wurdak, H., Schwerdtfeger, K., Kunz, T., Ille, F., Leveen, P., Hjalt, T., Suter, U., Karlsson, S., Hafezi, F., et al (2005). Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells. Journal of Biology, 4(3 (article 11)).
  • Wurdak, H., Ittner, L., Lang, K., Leveen, P., Suter, U., Fischer, J., Karlsson, S., Born, W., Sommer, L. (2005). Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes and Development, 19(5), 530-535. [More Information]
  • Kleber, M., Lee, H., Wurdak, H., Buchstaller, J., Riccomagno, M., Ittner, L., Suter, U., Epstein, D., Sommer, L. (2005). Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling. The Journal of Cell Biology, 169(2), 309-320. [More Information]
  • Goetz, J., Ittner, L., David, D. (2005). Role of the protein tau in Alzheimer's disease. Drug Discovery Today: Disease Mechanisms, 2(4), 395-400.
  • Ittner, L., Koller, D., Muff, R., Fischer, J., Born, W. (2005). The N-Terminal Extracellular Domain 23-60 of the Calcitonin Receptor-Like Receptor in Chimeras with the Parathyroid Hormone Receptor Mediates Association with Receptor Activity-Modifying Protein 1. Biochemistry, 44(15), 5749-5754. [More Information]
  • Lang, K., Recher, M., Junt, T., Navarini, A., Harris, N., Freigang, S., Odermatt, B., Conrad, C., Ittner, L., Bauer, S., et al (2005). Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nature Medicine, 11(2), 138-145. [More Information]
  • Kelm, J., Sanchez-Bustamante, C., Ehler, E., Hoerstrup, S., Djonov, V., Ittner, L., Fussenegger, M. (2005). VEGF profiling and angiogenesis in human microtissues. Journal of Biotechnology, 118(2), 213-229. [More Information]
  • Ittner, L., Luessi, F., Koller, D., Born, W., Fischer, J., Muff, R. (2004). Aspartate69 of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2. Biochemical and Biophysical Research Communications, 319(4), 1203-1209. [More Information]
  • Koller, D., Ittner, L., Muff, R., Husmann, K., Fischer, J., Born, W. (2004). Selective Inactivation of Adrenomedullin over Calcitonin Gene-related Peptide Receptor Function by the Deletion of Amino Acids 14-20 of the Mouse Calcitonin-like Receptor. Journal of Biological Chemistry, 279(19), 20387-20391.

2014

  • Gladbach, A., Van Eersel, J., Bi, M., Ke, Y., Ittner, L. (2014). ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke. Journal of Neural Transmission, 121(5), 543-547. [More Information]
  • Delerue, F., White, M., Ittner, L. (2014). Inducible, tightly regulated and non-leaky neuronal gene expression in mice. Transgenic Research, 23(2), 225-233. [More Information]

2013

  • Nilsen, L., Rae, C., Ittner, L., Goetz, J., Sonnewald, U. (2013). Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of Cerebral Blood Flow and Metabolism, 33(5), 684-691. [More Information]
  • Ong, W., Tanaka, K., Dawe, G., Ittner, L., Farooqui, A. (2013). Slow Excitotoxicity in Alzheimer's Disease. Journal of Alzheimer's Disease, 35(4), 643-668. [More Information]

2012

  • Gotz, J., Matamales, M., Gotz, N., Ittner, L., Eckert, A. (2012). Alzheimer's disease models and functional genomics-How many needles are there in the haystack? Frontiers in Physiology, 3, 1-14. [More Information]
  • Scarf, A., Luus, C., Da Pozzo, E., Selleri, S., Guarino, C., Martini, C., Ittner, L., Kassiou, M. (2012). Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa). Current Molecular Medicine, 12(4), 488-493. [More Information]
  • Ke, Y., Suchowerska, A., Hoven, J., De Silva, D., Wu, C., Van Eersel, J., Ittner, A., Ittner, L. (2012). Lessons from Tau-Deficient Mice. International Journal of Alzheimer's Disease, 2012 (Article ID 873270), 1-8. [More Information]
  • Schonrock, N., Sanchez Matamales, M., Ittner, L., Goetz, J. (2012). MicroRNA networks surrounding APP and amyloid-B metabolism - Implications for Alzheimer's disease. Experimental Neurology, 235(2), 447-454. [More Information]
  • Rosenmann, H., Blum, D., Kayed, R., Ittner, L. (2012). Tau protein: function and pathology. International Journal of Alzheimer's Disease, 2012, 707482-707482. [More Information]
  • Ke, Y., Dramiga, J., Schutz, U., Kril, J., Ittner, L., Schroder, H., Goetz, J. (2012). Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease. PLoS One, 7(4), 1-8. [More Information]
  • Goetz, J., Ittner, A., Ittner, L. (2012). Tau-targeted treatment strategies in Alzheimer's disease. British Journal of Pharmacology, 165(5), 1246-1259. [More Information]

2011

  • Ittner, L., Goetz, J. (2011). Amyloid-beta and tau - a toxic pas de deux in Alzheimer's disease. Nature Reviews. Neuroscience, 12(2), 67-72. [More Information]
  • Ittner, A., Ke, Y., Van Eersel, J., Gladbach, A., Goetz, J., Ittner, L. (2011). Brief update on different roles of tau in neurodegeneration. IUBMB Life, 63(7), 495-502. [More Information]
  • Van Eersel, J., Ke, Y., Gladbach, A., Bi, M., Goetz, J., Kril, J., Ittner, L. (2011). Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons. PLoS One, 6(7), 1-13. [More Information]
  • Liu, X., Dobbie, M., Tunningley, R., Whittle, B., Zhang, Y., Ittner, L., Goetz, J. (2011). ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice. Journal of Biomedicine and Biotechnology, 2011 (Article Number 130947), 1-11. [More Information]
  • Lim, Y., Grimm, A., Giese, M., Mensah-Nyagan, A., Villafranca, J., Ittner, L., Eckert, A., Goetz, J. (2011). Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS One, 6(12), e28887 - 1-e28887 - 12. [More Information]
  • Goetz, J., Ittner, L., Goetz, N., Lam, H., Nicholas, H. (2011). Invertebrate and Vertebrate Models of Tauopathies. In J. Avila, J. J. Lucas & F. Hernandez (Eds.), Animal Models for Neurodegenerative Disease, (pp. 69-85). Cambridge, UK: RSC Publishing.
  • Goetz, J., Eckert, A., Sanchez Matamales, M., Ittner, L., Liu, X. (2011). Modes of Abeta toxicity in Alzheimer's disease. Cellular and Molecular Life Sciences, 68(20), 3359-3375. [More Information]
  • Bi, M., Ittner, A., Ke, Y., Goetz, J., Ittner, L. (2011). Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice. PLoS One, 6(12), e26860-(7pp). [More Information]

2010

  • Lim, Y., Rhein, V., Baysang, G., Meier, F., Poljak, A., Raftery, M., Guilhaus, M., Ittner, L., Eckert, A., Goetz, J. (2010). Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics, 10(8), 1621-1633. [More Information]
  • Goetz, J., Gladbach, A., Pennanen, L., Van Eersel, J., Schild, A., David, D., Ittner, L. (2010). Animal models reveal role for tau phosphorylation in human disease. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1802 (10), 860-871. [More Information]
  • Ittner, L., Ke, Y., Delerue, F., Bi, M., Gladbach, A., Van Eersel, J., Wolfing, H., Chieng, B., Christie, M., Napier, I., Goetz, J., et al (2010). Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell, 142(3), 387-397. [More Information]
  • Goetz, J., Lim, Y., Ke, Y., Eckert, A., Ittner, L. (2010). Dissecting Toxicity of Tau and beta-Amyloid. Neurodegenerative Diseases, 7(1), 10-12. [More Information]
  • Krupka, N., Strappe, P., Goetz, J., Ittner, L. (2010). Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid, 63(3), 155-160. [More Information]
  • Schonrock, N., Ke, Y., Humphreys, D., Staufenbiel, M., Ittner, L., Preiss, T., Goetz, J. (2010). Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-beta. PLoS One, 5(6), e11070-1-e11070-11. [More Information]
  • Van Eersel, J., Ke, Y., Liu, X., Delerue, F., Kril, J., Goetz, J., Ittner, L. (2010). Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 107(31), 13888-13893. [More Information]

2009

  • Goetz, J., Schonrock, N., Vissel, B., Ittner, L. (2009). Alzheimer’s Disease Selective Vulnerability and Modeling in Transgenic Mice. Journal of Alzheimer's Disease, 18(2), 243-251. [More Information]
  • Wiesner, A., Rhein, V., Song, X., Ittner, L., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Drose, S., Brandt, U., Goetz, J., et al (2009). Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 106(47), 20057-20062. [More Information]
  • Goetz, J., Ittner, L., Lim, Y. (2009). Common features between diabetes mellitus and Alzheimer's disease. Cellular and Molecular Life Sciences, 66(8), 1321-1325. [More Information]
  • Ke, Y., Delerue, F., Gladbach, A., Goetz, J., Ittner, L. (2009). Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease. PLoS One, 4(11), e7917 - 1-e7917 - 7. [More Information]
  • Ittner, L., Ke, Y., Goetz, J. (2009). Phosphorylated tau interacts with c-JUN N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer''s disease. Journal of Biological Chemistry, 284(31), 20909-20916. [More Information]
  • Van Eersel, J., Bi, M., Ke, Y., Hodges, J., Xuereb, J., Gregory, G., Halliday, G., Goetz, J., Kril, J., Ittner, L. (2009). Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of Neural Transmission, 116(10), 1243-1251. [More Information]
  • Fath, T., Ke, Y., Gunning, P., Goetz, J., Ittner, L. (2009). Primary support cultures of hippocampal and substantia nigra neurons. Nature Protocols (Print), 4(1), 78-85. [More Information]
  • Goetz, J., Ittner, L., Lim, Y. (2009). Response to the comment 'Iron, type 2 diabetes mellitus, and Alzheimer's disease' to our Visions and Reflections article 'Common features between diabetes mellitus and Alzheimer's disease'. Cellular and Molecular Life Sciences, 66(17), 2945-2945. [More Information]
  • Deters, N., Ittner, L., Goetz, J. (2009). Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and Biophysical Research Communications, 379(2), 400-405. [More Information]
  • Scarf, A., Ittner, L., Kassiou, M. (2009). The translocator protein (18 kDa): Central nervous system disease and drug design. Journal of Medicinal Chemistry, 52(3), 581-592. [More Information]

2008

  • Goetz, J., Ittner, L., Schonrock, N., Cappai, R. (2008). An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatric Disease and Treatment, 4(6), 1033-1042. [More Information]
  • Goetz, J., Ittner, L. (2008). Animal models of Alzheimer's disease and frontotemporal dementia. Nature Reviews. Neuroscience, 9(7), 532-544. [More Information]
  • Falk, S., Wurdak, H., Ittner, L., Ille, F., Sumara, G., Schmid, M., Draganova, K., Lang, K., Paratore, C., Leveen, P., et al (2008). Brain Area-Specific Effect of TGF-β Signaling on Wnt-Dependent Neural Stem Cell Expansion. Cell Stem Cell, 2(5), 472-483. [More Information]
  • Deters, N., Ittner, L., Goetz, J. (2008). Divergent phosphorylation pattern of tau in P301L tau transgenic mice. European Journal of Neuroscience, 28(1), 137-147. [More Information]
  • Goetz, J., David, D., Hoerndli, F., Ke, Y., Schonrock, N., Wiesner, A., Fath, T., Bokhari, Y., Lim, Y., Deters, N., Ittner, L. (2008). Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neurodegenerative Diseases, 5, 179-181. [More Information]
  • Lim, Y., Ittner, L., Lim, Y., Goetz, J. (2008). Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS Letters, 582(15), 2188-2194. [More Information]
  • Goetz, J., Ittner, L., Fandrich, M., Schonrock, N. (2008). Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods? Journal of Alzheimer's Disease, 14(4), 423-429. [More Information]
  • Ittner, L., Fath, T., Ke, Y., Bi, M., Van Eersel, J., Li, K., Gunning, P., Goetz, J. (2008). Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 105(41), 15997-6002. [More Information]
  • Ittner, L., Schwerdtfeger, K., Kunz, T., Muff, R., Husmann, K., Grimm, C., Hafezi, F., Lang, K., Kurrer, M., Born, W., Goetz, J., et al (2008). Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clinical Science, 114(1), 49-58. [More Information]

2007

  • Goetz, J., Deters, N., Doldissen, A., Bokhari, Y., Ke, Y., Wiesner, A., Schonrock, N., Ittner, L. (2007). A decade of tau transgenic animal models and beyond. Brain Pathology, 17(1), 91-103. [More Information]
  • Kunz, T., Scott, M., Ittner, L., Fischer, J., Born, W., Vogel, J. (2007). Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity. American Journal of Physiology: Heart and Circulatory Physiology, 293(4), H2155-H2160. [More Information]
  • Stanescu, D., Iseli, H., Schwerdtfeger, K., Ittner, L., Reme, C., Hafezi, F. (2007). Continuous expression of the homeobox gene Pax6 in the ageing human retina. Eye, 21(1), 90-93. [More Information]
  • Kunz, T., Mueller-Steiner, S., Schwerdtfeger, K., Kleinert, P., Troxler, H., Kelm, J., Ittner, L., Fischer, J., Born, W. (2007). Interaction of receptor-activity-modifying protein1 with tubulin. BBA - Bioenergetics, 1770 (8), 1145-1150. [More Information]
  • Ittner, L., Goetz, J. (2007). Pronuclear injection for the production of transgenic mice. Nature Protocols (Print), 2(5), 1206-1215. [More Information]
  • Ille, F., Atanasoski, S., Falk, S., Ittner, L., Maerki, D., Buechmann-Moller, S., Wurdak, H., Suter, U., Taketo, M., Sommer, L. (2007). Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord. Developmental Biology, 304(1), 394-408. [More Information]

2006

  • Schild, A., Schmidt, K., Lim, Y., Ke, Y., Ittner, L., Hemmings, B., Goetz, J. (2006). Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. International Journal of Developmental Neuroscience, 24(7), 437-443. [More Information]
  • Schild, A., Ittner, L., Goetz, J. (2006). Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochemical and Biophysical Research Communications, 343(4), 1171-1178. [More Information]
  • Goetz, J., Ittner, L., Schonrock, N. (2006). Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy? Medical Journal of Australia, 185(7), 381-384. [More Information]
  • David, D., Ittner, L., Gehrig, P., Nergenau, D., Shepherd, C., Halliday, G., Goetz, J. (2006). beta-Amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics, 6(24), 6566-6577. [More Information]
  • Wurdak, H., Ittner, L., Sommer, L. (2006). DiGeorge syndrome and pharyngeal apparatus development. BioEssays, 28(11), 1078-1086. [More Information]
  • Goetz, J., Ittner, L., Kins, S. (2006). Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease? Journal of Neurochemistry, 98(4), 993-1006. [More Information]
  • Tam, C., Husmann, K., Clark, N., Clark, J., Lazar, Z., Ittner, L., Goetz, J., Douglas, G., Grant, A., Sugden, D., et al (2006). Enhanced Vascular Responses to Adrenomedullin in Mice Overexpressing Receptor-Activity-Modifying Protein 2. Circulation Research, 98(2), 262-270. [More Information]
  • Ittner, L., David, D., Goetz, J. (2006). Impact of beta-amyloid on the tau pathology in tau transgenic mouse and tissue culture models. In Colin J Barrow, David H Small (Eds.), Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research, (pp. 198-215). United Kingdom: Springer UK.
  • Schild, A., Isenmann, S., Tanimoto, N., Tonagel, F., Seeliger, M., Ittner, L., Kretz, A., Ogris, E., Goetz, J. (2006). Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice. Mechanisms of Development, 123(5), 362-371. [More Information]
  • Kelm, J., Ittner, L., Born, W., Djonov, V., Fussenegger, M. (2006). Self-assembly of sensory neurons into ganglia-like microtissues. Journal of Biotechnology, 121(1), 86-101. [More Information]
  • Kelm, J., Djonov, V., Hoerstrup, S., Guenter, C., Ittner, L., Greve, F., Hierlemann, A., Sanchez-Bustamante, C., Perriard, J., Ehler, E., et al (2006). Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats. Tissue Engineering. Part A, 12(9), 2541-2553. [More Information]

2005

  • Ittner, L., Wurdak, H., Schwerdtfeger, K., Kunz, T., Ille, F., Leveen, P., Hjalt, T., Suter, U., Karlsson, S., Hafezi, F., et al (2005). Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells. Journal of Biology, 4(3 (article 11)).
  • Wurdak, H., Ittner, L., Lang, K., Leveen, P., Suter, U., Fischer, J., Karlsson, S., Born, W., Sommer, L. (2005). Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes and Development, 19(5), 530-535. [More Information]
  • Kleber, M., Lee, H., Wurdak, H., Buchstaller, J., Riccomagno, M., Ittner, L., Suter, U., Epstein, D., Sommer, L. (2005). Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling. The Journal of Cell Biology, 169(2), 309-320. [More Information]
  • Goetz, J., Ittner, L., David, D. (2005). Role of the protein tau in Alzheimer's disease. Drug Discovery Today: Disease Mechanisms, 2(4), 395-400.
  • Ittner, L., Koller, D., Muff, R., Fischer, J., Born, W. (2005). The N-Terminal Extracellular Domain 23-60 of the Calcitonin Receptor-Like Receptor in Chimeras with the Parathyroid Hormone Receptor Mediates Association with Receptor Activity-Modifying Protein 1. Biochemistry, 44(15), 5749-5754. [More Information]
  • Lang, K., Recher, M., Junt, T., Navarini, A., Harris, N., Freigang, S., Odermatt, B., Conrad, C., Ittner, L., Bauer, S., et al (2005). Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nature Medicine, 11(2), 138-145. [More Information]
  • Kelm, J., Sanchez-Bustamante, C., Ehler, E., Hoerstrup, S., Djonov, V., Ittner, L., Fussenegger, M. (2005). VEGF profiling and angiogenesis in human microtissues. Journal of Biotechnology, 118(2), 213-229. [More Information]

2004

  • Ittner, L., Luessi, F., Koller, D., Born, W., Fischer, J., Muff, R. (2004). Aspartate69 of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2. Biochemical and Biophysical Research Communications, 319(4), 1203-1209. [More Information]
  • Koller, D., Ittner, L., Muff, R., Husmann, K., Fischer, J., Born, W. (2004). Selective Inactivation of Adrenomedullin over Calcitonin Gene-related Peptide Receptor Function by the Deletion of Amino Acids 14-20 of the Mouse Calcitonin-like Receptor. Journal of Biological Chemistry, 279(19), 20387-20391.

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