Dr Laurence Macia

a'Beckett Fellow, School of Medical Sciences / Pathology

Member of The University of Sydney Nano Institute

Member of the Charles Perkins Centre


Map

Current research students

Project title Research student
The carbohydrate dimension of nutrition in gut microbiome modulation Alison LUK
Delivery of anti-inflammatory extracellular vesicles via aerosolisation for treatment of inflammatory lung diseases Thanh Huyen PHAN

Keywords

Microbiology; Autoimmunity; Diet; Allergy; Immune system diseases

Clinical Specialty

Infection and Immunity

Selected grants

2018

  • Sydney Nano Research Collaboration Award; Macia L; Australian Institute of Nanoscience and Technology (AINST)/Research Collaboration Award.

2017

  • Nutritional and bacterial influences on gut and peripheral homeostasis; Macia L, Simpson S, Ashton J, Mackay C; Australian Research Council (ARC)/Linkage Projects (LP).
  • ANSTO Funding Agreement Postdoctoral Fellow; Macia L; ANSTO/Fellowship.
  • Manipulate immune tolerance to improve rheumatoid arthritis; Macia L; Rebecca L Cooper Medical Research Foundation/Research Grant.
  • Alleviating rheumatoid arthritis by manipulating gut microbiota through dietary fibre supplementation; Macia L; Sydney Medical School Foundation/Foundation Grant.
  • SMS-FEIT Biomedical Engineering Research Collaboration Scheme 2016-2017; Macia L; Sydney Medical School/SMS-FEIT Biomedical Engineering Research Collaboration Scheme.
  • Health Innovation project - A project-based unit built in partnership between researchers & industries in a global context (Project-based units); Caillaud C, Yacef K, Carroll M, Halaki M, Keep M, McCabe P, Haq I, Oakeshott J, Sayan A, Gregoire M, Macia L, Higgins C; DVC Education/Large Educational Innovation Grant.

2016

  • Impact of dietary fibre on rheumatoid arthritis; Macia L; Sydney Medical School/Kickstart Grant.

2014

  • Diet and the gut microbiota as the basis for food allergies; Macia L, Mackay C; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Simpson, S., Raubenheimer, D., Cogger, V., Macia, L., Solon-Biet, S., Le Couteur, D., George, J. (2018). The nutritional geometry of liver disease including non-alcoholic fatty liver disease (NAFLD). Journal of Hepatology, 68(2), 316-325. [More Information]
  • Daien, C., Pinget, G., Tan, J., Macia, L. (2017). Detrimental impact of microbiota-accessible carbohydrate-deprived diet on gut and immune homeostasis: An overview. Frontiers in Immunology, 8, 1-7. [More Information]
  • Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M., Konijn, T., Knippenberg, M., Cook, E., Hanekamp, D., et al (2017). Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells. Journal of Immunology, 198(5), 2172-2181. [More Information]
  • Vieira, A., Galvao, I., Macia, L., Sernaglia, E., Vinolo, M., Garcia, C., Tavares, L., Amaral, F., Sousa, L., et al (2017). Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. Journal of Leukocyte Biology, 101(1), 275-284. [More Information]
  • Marino, E., Richards, J., McLeod, K., Stanley, D., Yap, Y., Knight, J., McKenzie, C., Kranich, J., Oliveira, A., Macia, L., et al (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology, 18(5), 552-562. [More Information]
  • Tan, J., McKenzie, C., Marino, E., Macia, L., Mackay, C. (2017). Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation. Annual Review of Immunology, 35, 371-402. [More Information]
  • Vuillermin, P., Macia, L., Nanan, R., Tang, M., Collier, F., Brix, S. (2017). The maternal microbiome during pregnancy and allergic disease in the offspring. Seminars in Immunopathology, 39(6), 669-675. [More Information]
  • McKenzie, C., Tan, J., Macia, L., Mackay, C. (2017). The nutrition-gut microbiome-physiology axis and allergic diseases. Immunological Reviews, 278(1), 277-295. [More Information]
  • Chevalier, N., Tan, J., Mason, L., Robert, R., McKenzie, C., Lim, F., Wong, C., Macia, L., Thorburn, A., Russ, B., et al (2016). Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges. Journal of Autoimmunity, 73, 120-129. [More Information]
  • Tan, J., McKenzie, C., Vuillermin, P., Goverse, G., Vinuesa, C., Mebius, R., Macia, L., Mackay, C. (2016). Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Reports, 15(12), 2809-2824. [More Information]
  • Lassen, K., McKenzie, C., Mari, M., Murano, T., Begun, J., Baxt, L., Goel, G., Villablanca, E., Kuo, S., Macia, L., et al (2016). Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity, 44(6), 1392-1405. [More Information]
  • Chevalier, N., Macia, L., Tan, J., Mason, L., Robert, R., Thorburn, A., Wong, C., Tsai, L., Bourne, K., Brink, R., et al (2016). The role of T follicular helper cell molecules, and environmental influences, for autoantibody production and progression to inflammatory arthritis in Mice. Arthritis & Rheumatology, 68(4), 1026-1038. [More Information]
  • Vieira, A., Macia, L., Galvao, I., Martins, F., Canesso, M., Amaral, F., Garcia, C., Maslowski, K., De Leon, E., Shim, D., et al (2015). A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. Arthritis & Rheumatology, 67(6), 1646-1656. [More Information]
  • Thorburn, A., McKenzie, C., Shen, S., Stanley, D., Macia, L., Mason, L., Roberts, L., Wong, C., Shim, R., Robert, R., Mackay, C., et al (2015). Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nature Communications, 6, 1-13. [More Information]
  • McKenzie, C., Mackay, C., Macia, L. (2015). GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases. Trends in Endocrinology and Metabolism, 26(10), 511-512. [More Information]
  • Macia, L., Tan, J., Vieira, A., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., et al (2015). Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nature Communications, 6, 6734. [More Information]
  • Wang-Wei Tsai, V., Macia, L., Feinle-Bisset, C., Manandhar, R., Astrup, A., Raben, A., Lorenzen, J., Schmidt, P., Wiklund, F., Pedersen, N., Salis (nee Sainsbury), A., et al (2015). Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI. PloS One, 10(7), 1-15. [More Information]
  • Julia, V., Macia, L., Dombrowicz, D. (2015). The impact of diet on asthma and allergic diseases. Nature Reviews. Immunology, 15(5), 308-322. [More Information]
  • Thorburn, A., Macia, L., Mackay, C. (2014). Diet, metabolites, and "western-lifestyle" inflammatory diseases. Immunity, 40(6), 833-42. [More Information]
  • Nguyen, A., Slack, K., Schwarzer, C., Lee, N., Boey, D., Macia, L., Yulyaningsih, E., Enriquez, R., Zhang, L., Lin, S., Salis (nee Sainsbury), A., et al (2014). Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides, 48(3), 143-151. [More Information]
  • Chevalier, N., Thorburn, A., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P., Mackay, C. (2014). Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion. Journal of Immunology, 193(10), 4845-5488. [More Information]
  • Yulyaningsih, E., Loh, K., Lin, S., Lau, J., Zhang, L., Shi, Y., Berning, B., Enriquez, R., Driessler, F., Macia, L., Salis (nee Sainsbury), A., et al (2014). Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism, 19(1), 58-72. [More Information]
  • Tan, J., McKenzie, C., Potamitis, M., Thorburn, A., Mackay, C., Macia, L. (2014). The role of short-chain fatty acids in health and disease. Advances in Immunology, 121, 91-119. [More Information]
  • Tsai, V., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jorgensen, S., Lee-Ng, K., Zhang, H., Wu, L., Marquis, C., Salis (nee Sainsbury), A., et al (2013). TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. PloS One, 8(2), 1-10. [More Information]
  • Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Verwaerde, C., Spriet, C., Saule, P., Goormachtigh, G., et al (2012). Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PloS One, 7(6), e40351-0. [More Information]
  • Macie, L., Tsai, V., Nguyen, A., Johnen, H., Kuffner, T., Shi, Y., Lin, S., Herzog, H., Brown, D., Breit, S., Salis (nee Sainsbury), A. (2012). Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets. PloS One, 7(4), 1-8. [More Information]
  • Macia, L., Thorburn, A., Binge, L., Marino, E., Rogers, K., Maslowski, K., Vieira, A., Kranich, J., Mackay, C. (2012). Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunological Reviews, 245(1), 164-176. [More Information]
  • Macia, L., Yulyaningsih, E., Pangon, L., Nguyen, A., Lin, S., Shi, Y., Zhang, L., Bijker, M., Grey, S., Mackay, F., Salis (nee Sainsbury), A., et al (2012). Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity. Diabetes, 61(12), 3228-3238. [More Information]
  • Nguyen, A., Mitchell, N., Lin, S., Macia, L., Yulyaningsih, E., Baldock, P., Enriquez, R., Zhang, L., Shi, Y., Zolotukhin, S., Salis (nee Sainsbury), A., et al (2012). Y1 and Y5 Receptors are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice. PloS One, 7(6), 1-16. [More Information]
  • Shi, Y., Lin, S., Castillo, L., Aljanova, A., Enriquez, R., Baldock, P., Nguyen, A., Zhang, L., Bijker, M., Macia, L., Salis (nee Sainsbury), A., et al (2011). Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet-Induced Obesity. Obesity, 19(11), 2137-7148. [More Information]
  • Macia, L., Rao, P., Wheway, J., Sierro, F., Mackay, F., Herzog, H. (2011). Y1 signalling has a critical role in allergic airway inflammation. Immunology and Cell Biology, 89(8), 882-888. [More Information]
  • Shi, Y., Lin, S., Wong, I., Baldock, P., Aljanova, A., Enriquez, R., Castillo, L., Mitchell, N., Ye, J., Zhang, L., Salis (nee Sainsbury), A., et al (2010). NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice. PloS One, 5(6), 1-16. [More Information]
  • Lin, S., Shi, Y., Yulyaningsih, E., Aljanova, A., Zhang, L., Macia, L., Nguyen, A., Lin, E., During, M., Herzog, H., Salis (nee Sainsbury), A. (2009). Critical role of arcuate y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PloS One, 4(12), e8488-e8488. [More Information]

2018

  • Simpson, S., Raubenheimer, D., Cogger, V., Macia, L., Solon-Biet, S., Le Couteur, D., George, J. (2018). The nutritional geometry of liver disease including non-alcoholic fatty liver disease (NAFLD). Journal of Hepatology, 68(2), 316-325. [More Information]

2017

  • Daien, C., Pinget, G., Tan, J., Macia, L. (2017). Detrimental impact of microbiota-accessible carbohydrate-deprived diet on gut and immune homeostasis: An overview. Frontiers in Immunology, 8, 1-7. [More Information]
  • Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M., Konijn, T., Knippenberg, M., Cook, E., Hanekamp, D., et al (2017). Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells. Journal of Immunology, 198(5), 2172-2181. [More Information]
  • Vieira, A., Galvao, I., Macia, L., Sernaglia, E., Vinolo, M., Garcia, C., Tavares, L., Amaral, F., Sousa, L., et al (2017). Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. Journal of Leukocyte Biology, 101(1), 275-284. [More Information]
  • Marino, E., Richards, J., McLeod, K., Stanley, D., Yap, Y., Knight, J., McKenzie, C., Kranich, J., Oliveira, A., Macia, L., et al (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology, 18(5), 552-562. [More Information]
  • Tan, J., McKenzie, C., Marino, E., Macia, L., Mackay, C. (2017). Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation. Annual Review of Immunology, 35, 371-402. [More Information]
  • Vuillermin, P., Macia, L., Nanan, R., Tang, M., Collier, F., Brix, S. (2017). The maternal microbiome during pregnancy and allergic disease in the offspring. Seminars in Immunopathology, 39(6), 669-675. [More Information]
  • McKenzie, C., Tan, J., Macia, L., Mackay, C. (2017). The nutrition-gut microbiome-physiology axis and allergic diseases. Immunological Reviews, 278(1), 277-295. [More Information]

2016

  • Chevalier, N., Tan, J., Mason, L., Robert, R., McKenzie, C., Lim, F., Wong, C., Macia, L., Thorburn, A., Russ, B., et al (2016). Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges. Journal of Autoimmunity, 73, 120-129. [More Information]
  • Tan, J., McKenzie, C., Vuillermin, P., Goverse, G., Vinuesa, C., Mebius, R., Macia, L., Mackay, C. (2016). Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Reports, 15(12), 2809-2824. [More Information]
  • Lassen, K., McKenzie, C., Mari, M., Murano, T., Begun, J., Baxt, L., Goel, G., Villablanca, E., Kuo, S., Macia, L., et al (2016). Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity, 44(6), 1392-1405. [More Information]
  • Chevalier, N., Macia, L., Tan, J., Mason, L., Robert, R., Thorburn, A., Wong, C., Tsai, L., Bourne, K., Brink, R., et al (2016). The role of T follicular helper cell molecules, and environmental influences, for autoantibody production and progression to inflammatory arthritis in Mice. Arthritis & Rheumatology, 68(4), 1026-1038. [More Information]

2015

  • Vieira, A., Macia, L., Galvao, I., Martins, F., Canesso, M., Amaral, F., Garcia, C., Maslowski, K., De Leon, E., Shim, D., et al (2015). A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. Arthritis & Rheumatology, 67(6), 1646-1656. [More Information]
  • Thorburn, A., McKenzie, C., Shen, S., Stanley, D., Macia, L., Mason, L., Roberts, L., Wong, C., Shim, R., Robert, R., Mackay, C., et al (2015). Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nature Communications, 6, 1-13. [More Information]
  • McKenzie, C., Mackay, C., Macia, L. (2015). GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases. Trends in Endocrinology and Metabolism, 26(10), 511-512. [More Information]
  • Macia, L., Tan, J., Vieira, A., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., et al (2015). Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nature Communications, 6, 6734. [More Information]
  • Wang-Wei Tsai, V., Macia, L., Feinle-Bisset, C., Manandhar, R., Astrup, A., Raben, A., Lorenzen, J., Schmidt, P., Wiklund, F., Pedersen, N., Salis (nee Sainsbury), A., et al (2015). Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI. PloS One, 10(7), 1-15. [More Information]
  • Julia, V., Macia, L., Dombrowicz, D. (2015). The impact of diet on asthma and allergic diseases. Nature Reviews. Immunology, 15(5), 308-322. [More Information]

2014

  • Thorburn, A., Macia, L., Mackay, C. (2014). Diet, metabolites, and "western-lifestyle" inflammatory diseases. Immunity, 40(6), 833-42. [More Information]
  • Nguyen, A., Slack, K., Schwarzer, C., Lee, N., Boey, D., Macia, L., Yulyaningsih, E., Enriquez, R., Zhang, L., Lin, S., Salis (nee Sainsbury), A., et al (2014). Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides, 48(3), 143-151. [More Information]
  • Chevalier, N., Thorburn, A., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P., Mackay, C. (2014). Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion. Journal of Immunology, 193(10), 4845-5488. [More Information]
  • Yulyaningsih, E., Loh, K., Lin, S., Lau, J., Zhang, L., Shi, Y., Berning, B., Enriquez, R., Driessler, F., Macia, L., Salis (nee Sainsbury), A., et al (2014). Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism, 19(1), 58-72. [More Information]
  • Tan, J., McKenzie, C., Potamitis, M., Thorburn, A., Mackay, C., Macia, L. (2014). The role of short-chain fatty acids in health and disease. Advances in Immunology, 121, 91-119. [More Information]

2013

  • Tsai, V., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jorgensen, S., Lee-Ng, K., Zhang, H., Wu, L., Marquis, C., Salis (nee Sainsbury), A., et al (2013). TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. PloS One, 8(2), 1-10. [More Information]

2012

  • Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Verwaerde, C., Spriet, C., Saule, P., Goormachtigh, G., et al (2012). Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PloS One, 7(6), e40351-0. [More Information]
  • Macie, L., Tsai, V., Nguyen, A., Johnen, H., Kuffner, T., Shi, Y., Lin, S., Herzog, H., Brown, D., Breit, S., Salis (nee Sainsbury), A. (2012). Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets. PloS One, 7(4), 1-8. [More Information]
  • Macia, L., Thorburn, A., Binge, L., Marino, E., Rogers, K., Maslowski, K., Vieira, A., Kranich, J., Mackay, C. (2012). Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunological Reviews, 245(1), 164-176. [More Information]
  • Macia, L., Yulyaningsih, E., Pangon, L., Nguyen, A., Lin, S., Shi, Y., Zhang, L., Bijker, M., Grey, S., Mackay, F., Salis (nee Sainsbury), A., et al (2012). Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity. Diabetes, 61(12), 3228-3238. [More Information]
  • Nguyen, A., Mitchell, N., Lin, S., Macia, L., Yulyaningsih, E., Baldock, P., Enriquez, R., Zhang, L., Shi, Y., Zolotukhin, S., Salis (nee Sainsbury), A., et al (2012). Y1 and Y5 Receptors are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice. PloS One, 7(6), 1-16. [More Information]

2011

  • Shi, Y., Lin, S., Castillo, L., Aljanova, A., Enriquez, R., Baldock, P., Nguyen, A., Zhang, L., Bijker, M., Macia, L., Salis (nee Sainsbury), A., et al (2011). Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet-Induced Obesity. Obesity, 19(11), 2137-7148. [More Information]
  • Macia, L., Rao, P., Wheway, J., Sierro, F., Mackay, F., Herzog, H. (2011). Y1 signalling has a critical role in allergic airway inflammation. Immunology and Cell Biology, 89(8), 882-888. [More Information]

2010

  • Shi, Y., Lin, S., Wong, I., Baldock, P., Aljanova, A., Enriquez, R., Castillo, L., Mitchell, N., Ye, J., Zhang, L., Salis (nee Sainsbury), A., et al (2010). NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice. PloS One, 5(6), 1-16. [More Information]

2009

  • Lin, S., Shi, Y., Yulyaningsih, E., Aljanova, A., Zhang, L., Macia, L., Nguyen, A., Lin, E., During, M., Herzog, H., Salis (nee Sainsbury), A. (2009). Critical role of arcuate y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PloS One, 4(12), e8488-e8488. [More Information]

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