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Dr Laurence Macia

Senior Research Fellow
Physiology :School Medical Sciences

Member of The University of Sydney Nano Institute

Member of the Charles Perkins Centre


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Current research students

Project title Research student
The carbohydrate matrix, nitrogen source and fat as a lever to manipulate the gut microbial community state Alison LUK
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Keywords

Microbiology; Autoimmunity; Diet; Allergy; Immune system diseases

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Clinical Specialty

Infection and Immunity

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Selected grants

2018

  • Sydney Nano Research Collaboration Award; Macia L; Australian Institute of Nanoscience and Technology (AINST)/Research Collaboration Award.

2017

  • Nutritional and bacterial influences on gut and peripheral homeostasis; Macia L, Simpson S, Ashton J, Mackay C; Australian Research Council (ARC)/Linkage Projects (LP).
  • ANSTO Funding Agreement Postdoctoral Fellow; Macia L; ANSTO/Fellowship.
  • Manipulate immune tolerance to improve rheumatoid arthritis; Macia L; Rebecca L Cooper Medical Research Foundation/Research Grant.
  • Alleviating rheumatoid arthritis by manipulating gut microbiota through dietary fibre supplementation; Macia L; Sydney Medical School Foundation/Foundation Grant.
  • SMS-FEIT Biomedical Engineering Research Collaboration Scheme 2016-2017; Macia L; Sydney Medical School/SMS-FEIT Biomedical Engineering Research Collaboration Scheme.
  • Health Innovation project - A project-based unit built in partnership between researchers & industries in a global context (Project-based units); Caillaud C, Yacef K, Carroll M, Halaki M, Keep M, McCabe P, Haq I, Oakeshott J, Sayan A, Gregoire M, Macia L, Higgins C; DVC Education/Large Educational Innovation Grant.

2016

  • Impact of dietary fibre on rheumatoid arthritis; Macia L; Sydney Medical School/Kickstart Grant.

2014

  • Diet and the gut microbiota as the basis for food allergies; Macia L, Mackay C; National Health and Medical Research Council (NHMRC)/Project Grants.
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Selected publications

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Journals

  • Daien, C., Pinget, G., Tan, J., Macia, L. (2017). Detrimental impact of microbiota-accessible carbohydrate-deprived diet on gut and immune homeostasis: An overview. Frontiers in Immunology, 8, 1-7. [More Information]
  • Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M., Konijn, T., Knippenberg, M., Cook, E., Hanekamp, D., et al (2017). Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells. Journal of Immunology, 198(5), 2172-2181. [More Information]
  • Vieira, A., Galvao, I., Macia, L., Sernaglia, E., Vinolo, M., Garcia, C., Tavares, L., Amaral, F., Sousa, L., et al (2017). Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. Journal of Leukocyte Biology, 101(1), 275-284. [More Information]
  • Marino, E., Richards, J., McLeod, K., Stanley, D., Yap, Y., Knight, J., McKenzie, C., Kranich, J., Oliveira, A., Macia, L., et al (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology, 18(5), 552-562. [More Information]
  • Tan, J., McKenzie, C., Marino, E., Macia, L., Mackay, C. (2017). Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation. Annual Review of Immunology, 35, 371-402. [More Information]
  • Vuillermin, P., Macia, L., Nanan, R., Tang, M., Collier, F., Brix, S. (2017). The maternal microbiome during pregnancy and allergic disease in the offspring. Seminars in Immunopathology, 39(6), 669-675. [More Information]
  • McKenzie, C., Tan, J., Macia, L., Mackay, C. (2017). The nutrition-gut microbiome-physiology axis and allergic diseases. Immunological Reviews, 278(1), 277-295. [More Information]
  • Simpson, S., Raubenheimer, D., Cogger, V., Macia, L., Solon-Biet, S., Le Couteur, D., George, J. (2017). The nutritional geometry of liver disease including non-alcoholic fatty liver disease (NAFLD). Journal of Hepatology, 68(2), 316-325. [More Information]
  • Chevalier, N., Tan, J., Mason, L., Robert, R., McKenzie, C., Lim, F., Wong, C., Macia, L., Thorburn, A., Russ, B., et al (2016). Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges. Journal of Autoimmunity, 73, 120-129. [More Information]
  • Tan, J., McKenzie, C., Vuillermin, P., Goverse, G., Vinuesa, C., Mebius, R., Macia, L., Mackay, C. (2016). Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Reports, 15(12), 2809-2824. [More Information]
  • Lassen, K., McKenzie, C., Mari, M., Murano, T., Begun, J., Baxt, L., Goel, G., Villablanca, E., Kuo, S., Macia, L., et al (2016). Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity, 44(6), 1392-405. [More Information]
  • Chevalier, N., Macia, L., Tan, J., Mason, L., Robert, R., Thorburn, A., Wong, C., Tsai, L., Bourne, K., Brink, R., et al (2016). The role of T follicular helper cell molecules, and environmental influences, for autoantibody production and progression to inflammatory arthritis in Mice. Arthritis & Rheumatology, 68(4), 1026-1038. [More Information]
  • Vieira, A., Macia, L., Galvao, I., Martins, F., Canesso, M., Amaral, F., Garcia, C., Maslowski, K., De Leon, E., Shim, D., et al (2015). A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. Arthritis & Rheumatology, 67(6), 1646-1656. [More Information]
  • Thorburn, A., McKenzie, C., Shen, S., Stanley, D., Macia, L., Mason, L., Roberts, L., Wong, C., Shim, R., Robert, R., Mackay, C., et al (2015). Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nature Communications, 6, 1-13. [More Information]
  • McKenzie, C., Mackay, C., Macia, L. (2015). GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases. Trends in Endocrinology and Metabolism, 26(10), 511-512. [More Information]
  • Macia, L., Tan, J., Vieira, A., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., et al (2015). Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nature Communications, 6, 6734. [More Information]
  • Wang-Wei Tsai, V., Macia, L., Feinle-Bisset, C., Manandhar, R., Astrup, A., Raben, A., Lorenzen, J., Schmidt, P., Wiklund, F., Pedersen, N., Salis (nee Sainsbury), A., et al (2015). Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI. PloS One, 10(7), 1-15. [More Information]
  • Julia, V., Macia, L., Dombrowicz, D. (2015). The impact of diet on asthma and allergic diseases. Nature Reviews. Immunology, 15(5), 308-322. [More Information]
  • Thorburn, A., Macia, L., Mackay, C. (2014). Diet, metabolites, and "western-lifestyle" inflammatory diseases. Immunity, 40(6), 833-42. [More Information]
  • Nguyen, A., Slack, K., Schwarzer, C., Lee, N., Boey, D., Macia, L., Yulyaningsih, E., Enriquez, R., Zhang, L., Lin, S., Salis (nee Sainsbury), A., et al (2014). Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides, 48(3), 143-151. [More Information]
  • Chevalier, N., Thorburn, A., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P., Mackay, C. (2014). Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion. Journal of Immunology, 193(10), 4845-5488. [More Information]
  • Yulyaningsih, E., Loh, K., Lin, S., Lau, J., Zhang, L., Shi, Y., Berning, B., Enriquez, R., Driessler, F., Macia, L., Salis (nee Sainsbury), A., et al (2014). Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism, 19(1), 58-72. [More Information]
  • Tan, J., McKenzie, C., Potamitis, M., Thorburn, A., Mackay, C., Macia, L. (2014). The role of short-chain fatty acids in health and disease. Advances in Immunology, 121, 91-119. [More Information]
  • Tsai, V., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jorgensen, S., Lee-Ng, K., Zhang, H., Wu, L., Marquis, C., Salis (nee Sainsbury), A., et al (2013). TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. PloS One, 8(2), 1-10. [More Information]
  • Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Verwaerde, C., Spriet, C., Saule, P., Goormachtigh, G., et al (2012). Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PloS One, 7(6), e40351-0. [More Information]
  • Macie, L., Tsai, V., Nguyen, A., Johnen, H., Kuffner, T., Shi, Y., Lin, S., Herzog, H., Brown, D., Breit, S., Salis (nee Sainsbury), A. (2012). Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets. PloS One, 7(4), 1-8. [More Information]
  • Macia, L., Thorburn, A., Binge, L., Marino, E., Rogers, K., Maslowski, K., Vieira, A., Kranich, J., Mackay, C. (2012). Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunological Reviews, 245(1), 164-176. [More Information]
  • Macia, L., Yulyaningsih, E., Pangon, L., Nguyen, A., Lin, S., Shi, Y., Zhang, L., Bijker, M., Grey, S., Mackay, F., Salis (nee Sainsbury), A., et al (2012). Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity. Diabetes, 61(12), 3228-3238. [More Information]
  • Nguyen, A., Mitchell, N., Lin, S., Macia, L., Yulyaningsih, E., Baldock, P., Enriquez, R., Zhang, L., Shi, Y., Zolotukhin, S., Salis (nee Sainsbury), A., et al (2012). Y1 and Y5 Receptors are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice. PloS One, 7(6), 1-16. [More Information]
  • Shi, Y., Lin, S., Castillo, L., Aljanova, A., Enriquez, R., Baldock, P., Nguyen, A., Zhang, L., Bijker, M., Macia, L., Salis (nee Sainsbury), A., et al (2011). Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet-Induced Obesity. Obesity, 19(11), 2137-7148. [More Information]
  • Macia, L., Rao, P., Wheway, J., Sierro, F., Mackay, F., Herzog, H. (2011). Y1 signalling has a critical role in allergic airway inflammation. Immunology and Cell Biology, 89(8), 882-888. [More Information]
  • Shi, Y., Lin, S., Wong, I., Baldock, P., Aljanova, A., Enriquez, R., Castillo, L., Mitchell, N., Ye, J., Zhang, L., Salis (nee Sainsbury), A., et al (2010). NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice. PloS One, 5(6), 1-16. [More Information]
  • Lin, S., Shi, Y., Yulyaningsih, E., Aljanova, A., Zhang, L., Macia, L., Nguyen, A., Lin, E., During, M., Herzog, H., Salis (nee Sainsbury), A. (2009). Critical role of arcuate y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PloS One, 4(12), e8488-e8488. [More Information]

2017

  • Daien, C., Pinget, G., Tan, J., Macia, L. (2017). Detrimental impact of microbiota-accessible carbohydrate-deprived diet on gut and immune homeostasis: An overview. Frontiers in Immunology, 8, 1-7. [More Information]
  • Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M., Konijn, T., Knippenberg, M., Cook, E., Hanekamp, D., et al (2017). Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells. Journal of Immunology, 198(5), 2172-2181. [More Information]
  • Vieira, A., Galvao, I., Macia, L., Sernaglia, E., Vinolo, M., Garcia, C., Tavares, L., Amaral, F., Sousa, L., et al (2017). Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. Journal of Leukocyte Biology, 101(1), 275-284. [More Information]
  • Marino, E., Richards, J., McLeod, K., Stanley, D., Yap, Y., Knight, J., McKenzie, C., Kranich, J., Oliveira, A., Macia, L., et al (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology, 18(5), 552-562. [More Information]
  • Tan, J., McKenzie, C., Marino, E., Macia, L., Mackay, C. (2017). Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation. Annual Review of Immunology, 35, 371-402. [More Information]
  • Vuillermin, P., Macia, L., Nanan, R., Tang, M., Collier, F., Brix, S. (2017). The maternal microbiome during pregnancy and allergic disease in the offspring. Seminars in Immunopathology, 39(6), 669-675. [More Information]
  • McKenzie, C., Tan, J., Macia, L., Mackay, C. (2017). The nutrition-gut microbiome-physiology axis and allergic diseases. Immunological Reviews, 278(1), 277-295. [More Information]
  • Simpson, S., Raubenheimer, D., Cogger, V., Macia, L., Solon-Biet, S., Le Couteur, D., George, J. (2017). The nutritional geometry of liver disease including non-alcoholic fatty liver disease (NAFLD). Journal of Hepatology, 68(2), 316-325. [More Information]

2016

  • Chevalier, N., Tan, J., Mason, L., Robert, R., McKenzie, C., Lim, F., Wong, C., Macia, L., Thorburn, A., Russ, B., et al (2016). Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges. Journal of Autoimmunity, 73, 120-129. [More Information]
  • Tan, J., McKenzie, C., Vuillermin, P., Goverse, G., Vinuesa, C., Mebius, R., Macia, L., Mackay, C. (2016). Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Reports, 15(12), 2809-2824. [More Information]
  • Lassen, K., McKenzie, C., Mari, M., Murano, T., Begun, J., Baxt, L., Goel, G., Villablanca, E., Kuo, S., Macia, L., et al (2016). Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity, 44(6), 1392-405. [More Information]
  • Chevalier, N., Macia, L., Tan, J., Mason, L., Robert, R., Thorburn, A., Wong, C., Tsai, L., Bourne, K., Brink, R., et al (2016). The role of T follicular helper cell molecules, and environmental influences, for autoantibody production and progression to inflammatory arthritis in Mice. Arthritis & Rheumatology, 68(4), 1026-1038. [More Information]

2015

  • Vieira, A., Macia, L., Galvao, I., Martins, F., Canesso, M., Amaral, F., Garcia, C., Maslowski, K., De Leon, E., Shim, D., et al (2015). A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. Arthritis & Rheumatology, 67(6), 1646-1656. [More Information]
  • Thorburn, A., McKenzie, C., Shen, S., Stanley, D., Macia, L., Mason, L., Roberts, L., Wong, C., Shim, R., Robert, R., Mackay, C., et al (2015). Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nature Communications, 6, 1-13. [More Information]
  • McKenzie, C., Mackay, C., Macia, L. (2015). GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases. Trends in Endocrinology and Metabolism, 26(10), 511-512. [More Information]
  • Macia, L., Tan, J., Vieira, A., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., et al (2015). Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nature Communications, 6, 6734. [More Information]
  • Wang-Wei Tsai, V., Macia, L., Feinle-Bisset, C., Manandhar, R., Astrup, A., Raben, A., Lorenzen, J., Schmidt, P., Wiklund, F., Pedersen, N., Salis (nee Sainsbury), A., et al (2015). Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI. PloS One, 10(7), 1-15. [More Information]
  • Julia, V., Macia, L., Dombrowicz, D. (2015). The impact of diet on asthma and allergic diseases. Nature Reviews. Immunology, 15(5), 308-322. [More Information]

2014

  • Thorburn, A., Macia, L., Mackay, C. (2014). Diet, metabolites, and "western-lifestyle" inflammatory diseases. Immunity, 40(6), 833-42. [More Information]
  • Nguyen, A., Slack, K., Schwarzer, C., Lee, N., Boey, D., Macia, L., Yulyaningsih, E., Enriquez, R., Zhang, L., Lin, S., Salis (nee Sainsbury), A., et al (2014). Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides, 48(3), 143-151. [More Information]
  • Chevalier, N., Thorburn, A., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P., Mackay, C. (2014). Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion. Journal of Immunology, 193(10), 4845-5488. [More Information]
  • Yulyaningsih, E., Loh, K., Lin, S., Lau, J., Zhang, L., Shi, Y., Berning, B., Enriquez, R., Driessler, F., Macia, L., Salis (nee Sainsbury), A., et al (2014). Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism, 19(1), 58-72. [More Information]
  • Tan, J., McKenzie, C., Potamitis, M., Thorburn, A., Mackay, C., Macia, L. (2014). The role of short-chain fatty acids in health and disease. Advances in Immunology, 121, 91-119. [More Information]

2013

  • Tsai, V., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jorgensen, S., Lee-Ng, K., Zhang, H., Wu, L., Marquis, C., Salis (nee Sainsbury), A., et al (2013). TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. PloS One, 8(2), 1-10. [More Information]

2012

  • Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Verwaerde, C., Spriet, C., Saule, P., Goormachtigh, G., et al (2012). Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PloS One, 7(6), e40351-0. [More Information]
  • Macie, L., Tsai, V., Nguyen, A., Johnen, H., Kuffner, T., Shi, Y., Lin, S., Herzog, H., Brown, D., Breit, S., Salis (nee Sainsbury), A. (2012). Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets. PloS One, 7(4), 1-8. [More Information]
  • Macia, L., Thorburn, A., Binge, L., Marino, E., Rogers, K., Maslowski, K., Vieira, A., Kranich, J., Mackay, C. (2012). Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunological Reviews, 245(1), 164-176. [More Information]
  • Macia, L., Yulyaningsih, E., Pangon, L., Nguyen, A., Lin, S., Shi, Y., Zhang, L., Bijker, M., Grey, S., Mackay, F., Salis (nee Sainsbury), A., et al (2012). Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity. Diabetes, 61(12), 3228-3238. [More Information]
  • Nguyen, A., Mitchell, N., Lin, S., Macia, L., Yulyaningsih, E., Baldock, P., Enriquez, R., Zhang, L., Shi, Y., Zolotukhin, S., Salis (nee Sainsbury), A., et al (2012). Y1 and Y5 Receptors are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice. PloS One, 7(6), 1-16. [More Information]

2011

  • Shi, Y., Lin, S., Castillo, L., Aljanova, A., Enriquez, R., Baldock, P., Nguyen, A., Zhang, L., Bijker, M., Macia, L., Salis (nee Sainsbury), A., et al (2011). Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet-Induced Obesity. Obesity, 19(11), 2137-7148. [More Information]
  • Macia, L., Rao, P., Wheway, J., Sierro, F., Mackay, F., Herzog, H. (2011). Y1 signalling has a critical role in allergic airway inflammation. Immunology and Cell Biology, 89(8), 882-888. [More Information]

2010

  • Shi, Y., Lin, S., Wong, I., Baldock, P., Aljanova, A., Enriquez, R., Castillo, L., Mitchell, N., Ye, J., Zhang, L., Salis (nee Sainsbury), A., et al (2010). NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice. PloS One, 5(6), 1-16. [More Information]

2009

  • Lin, S., Shi, Y., Yulyaningsih, E., Aljanova, A., Zhang, L., Macia, L., Nguyen, A., Lin, E., During, M., Herzog, H., Salis (nee Sainsbury), A. (2009). Critical role of arcuate y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PloS One, 4(12), e8488-e8488. [More Information]
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