Dr Lay Khoon Too

John and Shirley Sarks Postdoctoral Research Associate

Member of the Charles Perkins Centre


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Selected publications

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Journals

  • Balaratnasingam, C., Cherepanoff, S., Dolz-Marco, R., Killingsworth, M., Chen, F., Mendis, R., Mrejen, S., Too, L., Gal-Or, O., Curcio, C., et al (2018). Cuticular Drusen: Clinical Phenotypes and Natural History Defined Using Multimodal Imaging. Ophthalmology, 125(1), 100-118. [More Information]
  • Too, L., Gracie, G., Hasic, E., Iwakura, J., Cherepanoff, S. (2017). Adult human retinal M�ller glia display distinct peripheral and macular expression of CD117 and CD44 stem cell-associated proteins. Acta histochemica, 119(2), 142-149. [More Information]
  • Jusof, F., Bakmiwewa, S., Weiser, S., Too, L., Metz, R., Prendergast, G., Fraser, S., Hunt, N., Ball, H. (2017). Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2. International Journal of Tryptophan Research, 10, 1-12. [More Information]
  • Hunt, N., Too, L., Khaw, L., Guo, J., Hee, L., Mitchell, A., Grau, G., Ball, H. (2017). The kynurenine pathway and parasitic infections that affect CNS function. Neuropharmacology, 112(Pt B), 389-398. [More Information]
  • Yau, B., Too, L., Ball, H., Hunt, N. (2017). TIGR4 strain causes more severe disease than WU2 strain in a mouse model of Streptococcus pneumoniae meningitis: A common pathogenic role for interferon-(gamma). Microbes and Infection, 19(7-8), 413-421. [More Information]
  • Too, L., McGregor, I., Baxter, A., Hunt, N. (2016). Altered behaviour and cognitive function following combined deletion of Toll-like receptors 2 and 4 in mice. Behavioural Brain Research, 303, 1-8. [More Information]
  • Too, L., Mitchell, A., McGregor, I., Hunt, N. (2016). Antibody-induced neutrophil depletion prior to the onset of pneumococcal meningitis influences long-term neurological complications in mice. Brain, Behavior, and Immunity, 56, 68-83. [More Information]
  • Too, L., Li, K., Suarna, C., Maghzal, G., Stocker, R., McGregor, I., Hunt, N. (2016). Behavioral and cognitive data in mice with different tryptophan-metabolizing enzymes knocked out. Data in Brief, 9, 275-287. [More Information]
  • Too, L., Li, K., Suarna, C., Maghzal, G., Stocker, R., McGregor, I., Hunt, N. (2016). Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function. Behavioural Brain Research, 312, 102-117. [More Information]
  • Yau, B., Mitchell, A., Too, L., Ball, H., Hunt, N. (2016). Interferon-y-induced nitric oxide synthase-2 contributes to blood/brain barrier dysfunction and acute mortality in experimental streptococcus pneumoniae meningitis. Journal of Interferon and Cytokine Research, 36(2), 86-99. [More Information]
  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis. Brain, Behavior, and Immunity, 35, 107-124. [More Information]
  • Too, L., Mitchell, A., Yau, B., Ball, H., McGregor, I., Hunt, N. (2014). Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis. Behavioural Brain Research, 263, 176-189. [More Information]
  • Too, L., McQuillan, J., Ball, H., Kanai, M., Nakamura, T., Funakoshi, H., McGregor, I., Hunt, N. (2014). The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behavioural Brain Research, 270, 179-195. [More Information]
  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis. Brain, Behavior, and Immunity, 40, 252-268. [More Information]
  • Mitchell, A., Yau, B., McQuillan, J., Ball, H., Too, L., Abtin, A., Hertzog, P., Leib, S., Jones, C., Gerega, S., Weninger, W., Hunt, N. (2012). Inflammasome-Dependent IFN-y Drives Pathogenesis in Streptococcus pneumoniae Meningitis. Journal of Immunology, 189(10), 4970-4980. [More Information]

2018

  • Balaratnasingam, C., Cherepanoff, S., Dolz-Marco, R., Killingsworth, M., Chen, F., Mendis, R., Mrejen, S., Too, L., Gal-Or, O., Curcio, C., et al (2018). Cuticular Drusen: Clinical Phenotypes and Natural History Defined Using Multimodal Imaging. Ophthalmology, 125(1), 100-118. [More Information]

2017

  • Too, L., Gracie, G., Hasic, E., Iwakura, J., Cherepanoff, S. (2017). Adult human retinal M�ller glia display distinct peripheral and macular expression of CD117 and CD44 stem cell-associated proteins. Acta histochemica, 119(2), 142-149. [More Information]
  • Jusof, F., Bakmiwewa, S., Weiser, S., Too, L., Metz, R., Prendergast, G., Fraser, S., Hunt, N., Ball, H. (2017). Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2. International Journal of Tryptophan Research, 10, 1-12. [More Information]
  • Hunt, N., Too, L., Khaw, L., Guo, J., Hee, L., Mitchell, A., Grau, G., Ball, H. (2017). The kynurenine pathway and parasitic infections that affect CNS function. Neuropharmacology, 112(Pt B), 389-398. [More Information]
  • Yau, B., Too, L., Ball, H., Hunt, N. (2017). TIGR4 strain causes more severe disease than WU2 strain in a mouse model of Streptococcus pneumoniae meningitis: A common pathogenic role for interferon-(gamma). Microbes and Infection, 19(7-8), 413-421. [More Information]

2016

  • Too, L., McGregor, I., Baxter, A., Hunt, N. (2016). Altered behaviour and cognitive function following combined deletion of Toll-like receptors 2 and 4 in mice. Behavioural Brain Research, 303, 1-8. [More Information]
  • Too, L., Mitchell, A., McGregor, I., Hunt, N. (2016). Antibody-induced neutrophil depletion prior to the onset of pneumococcal meningitis influences long-term neurological complications in mice. Brain, Behavior, and Immunity, 56, 68-83. [More Information]
  • Too, L., Li, K., Suarna, C., Maghzal, G., Stocker, R., McGregor, I., Hunt, N. (2016). Behavioral and cognitive data in mice with different tryptophan-metabolizing enzymes knocked out. Data in Brief, 9, 275-287. [More Information]
  • Too, L., Li, K., Suarna, C., Maghzal, G., Stocker, R., McGregor, I., Hunt, N. (2016). Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function. Behavioural Brain Research, 312, 102-117. [More Information]
  • Yau, B., Mitchell, A., Too, L., Ball, H., Hunt, N. (2016). Interferon-y-induced nitric oxide synthase-2 contributes to blood/brain barrier dysfunction and acute mortality in experimental streptococcus pneumoniae meningitis. Journal of Interferon and Cytokine Research, 36(2), 86-99. [More Information]

2014

  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis. Brain, Behavior, and Immunity, 35, 107-124. [More Information]
  • Too, L., Mitchell, A., Yau, B., Ball, H., McGregor, I., Hunt, N. (2014). Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis. Behavioural Brain Research, 263, 176-189. [More Information]
  • Too, L., McQuillan, J., Ball, H., Kanai, M., Nakamura, T., Funakoshi, H., McGregor, I., Hunt, N. (2014). The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behavioural Brain Research, 270, 179-195. [More Information]
  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis. Brain, Behavior, and Immunity, 40, 252-268. [More Information]

2012

  • Mitchell, A., Yau, B., McQuillan, J., Ball, H., Too, L., Abtin, A., Hertzog, P., Leib, S., Jones, C., Gerega, S., Weninger, W., Hunt, N. (2012). Inflammasome-Dependent IFN-y Drives Pathogenesis in Streptococcus pneumoniae Meningitis. Journal of Immunology, 189(10), 4970-4980. [More Information]

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