Dr Leanne Stokes

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Themes | Research interests | Grants | Honours project opportunities | Keywords

Themes

Infection and Immunological Conditions; Neurosciences and Mental Health

Research interests

The main focus of my work is investigation into the role of the P2X7 receptor in immune cells. The P2X7 receptor is a ligand-gated ion channel activated by extracellular ATP. It is expressed on a number of immune cells including monocytes, macrophages, T and B lymphocytes, natural killer (NK) cells and dendritic cells.

1 - Single nucleotide polymorphisms in the human P2RX7 gene

2 - The P2X7 receptor and genetic association with bipolar and unipolar disorders

3 - Physiological roles of the P2X7 receptor in immune cells

4 - P2Y2 receptor and secretion of chemokine MCP-1 from monocytes & macrophages

Current national competitive grants*

2010

P2X7 receptor and inflammation in the pathophysiology of mood disorders
Stokes L
NHMRC Project Grant ($555,500 over 3 years)

* Grants administered through the University of Sydney

Honours project opportunities

The P2X7 receptor in human T cell activation and IL-2 secretion
The P2X7 receptor, oxidative stress and inflammation
Role of P2Y receptors in inflammatory chemokine secretion

Keywords

Cells and cell physiology; Pharmacology; Inflammation; Cell biology; Genetics

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