Professor Les Irwig

Professor, Screening and Test Evaluation Program
Public Health, School of Public Health

Telephone +61 2 9351 4370
Fax +61 2 9351-5049

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Research interests

Epidemiological methods for screening, diagnostic test evaluation and meta-analysis.

Les is especially interested in the application of epidemiological methods to provide the evidence on which to base Public Health and Clinical decisions. His particular area of expertise is the assessment of screening and diagnostic tests through systematic review (meta-analysis) and the conduct of new studies.

Selected grants

2012

  • Analysis of lifestyle risk factor management for the Heart Foundation; Bonner C, McCaffery K, Jansen J, Dhillon H, McKinn S, Irwig L; Heart Foundation of Australia/Research Support.

2011

  • Implementation and cost-effectiveness of absolute risk for prevention of cardiovascular disease in Australia; Barendregt J, Jackson C, Vos E, Irwig L, Doust J; National Health and Medical Research Council (NHMRC)/Strategic Awards: General Practice Clinical Research Program Grant.
  • Screening and Test Evaluation Program STEP; Irwig L, Glasziou P, Craig J, Salkeld G, Macaskill P; National Health and Medical Research Council (NHMRC)/Program Grants.

2007

  • Improving population health by a multidisciplinary, multi-method focus kidney disease of the young, the old, and of Indigenous Australians; Craig J, Cass A, Irwig L, Chadban S, McDonald S, Devitt J, Macaskill P, Jones M, Howard K, Salkeld G; National Health and Medical Research Council (NHMRC)/Capacity Building Grant.

2006

  • Screening and Test Evaluation Program (STEP); Bell K, Irwig L, Craig J, Salkeld G, Macaskill P; National Health and Medical Research Council (NHMRC)/Program Grants.

2005

  • Respiratory and Sleep Medicine; Jenkins C, Hensley M, Alison J, Britton W, Irwig L, Rogers N, Rose B, Marks G, Grunstein R, Bye P, Anderson S, King G, Berend N, Gibson P; National Health and Medical Research Council (NHMRC)/Centre of Clinical Research Excellence.

2004

  • A randomised placebo-controlled trial of antibiotics to prevent urinary tract infection in children; Craig J, Roy L, Reynolds G, Carapetis J, Smith G, Irwig L, Smith G, Carapetis J; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Centre of clinical research excellence in renal medicine; Walker R, Atkins R, Craig J, Chadban S, Irwig L, Harris D, O'Connell P, Walker R, Chadban S, Atkins R, Irwig L; National Health and Medical Research Council (NHMRC)/Centre of Clinical Research Excellence.

2002

  • Screening and diagnosis: accuracy outcomes and informed decision-making; Irwig L, Barratt A, Craig J, Salkeld G, Glasziou P, Macaskill P; National Health and Medical Research Council (NHMRC)/Program Grants.

2000

  • A randomised trial of oxygen therapy on growth and development of preterm infants; Henderson-Smart D, Irwig L, Simpson J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Provision of assessment and research related services on medical technologies and procedures for the Medical Services Advisory Committee (MSAC); Simes R, Eckermann S, Keech A, Irwig L, Ghersi D, Stockler M, Gebski V, Eckermann S, Lord S, Howard K, Salkeld G; Department of Health and Ageing (Federal)/Research Support.
  • PAPNET as a primary screening procedure; Irwig L; NSI Australia Pty Limited/Research Support.
  • A randomised trial of oxygen therapy on growth and development of infants; Henderson-Smart D, Irwig L; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Books

  • Irwig, L., Irwig, J., Trevena, L., Sweet, M. (2008). Smart Health Choices: Making sense of health advice. United Kingdom: Hammersmith Press.
  • Irwig, L., Trevena, L., Judy, I., Sweet, M. (2007). Smart Health Choices: Making sense of health advice. United Kingdom: Hammersmith Press.
  • Campbell, D., de Campo, M., Elwood, M., Fong, K., Irwig, L., Manser, R., Peters, M., Pederson, K., St John, J. (2003). Lung Cancer Screening By Helical Computed Tomography. VIC: National Cancer Control Initiative.
  • Irwig, L., Glasziou, P., Bain,, C., Colditz, G. (2001). Systematic Reviews in Health Care: A Practical Guide. Australia: Cambridge University Press.

Edited Books

  • Glasziou, P., Irwig, L., Aronson, J. (2008). Evidence-based Medical Monitoring:From Principles to Practice. Oxford: Blackwell Publishers.

Book Chapters

  • Irwig, L., Bossuyt, P., Glasziou, P., Gatsonis, C., Lijmer, J. (2009). Designing studies to ensure that estimates of test accuracy will travel. In J. Andre Knottnerus, Frank Buntinx (Eds.), The Evidence Base of Clinical Diagnosis: Theory and Methods of Diagnostic Research, (pp. 96-117). West Sussex, UK: Wiley-Blackwell Publishing.
  • Irwig, L., Glasziou, P. (2008). Choosing the best monitoring tests. In P Glasziou, L Irwig and J K Aronson (Eds.), Evidence-based Medical Monitoring:From Principles to Practice, (pp. 63-74). Oxford: Blackwell Publishers.
  • Glasziou, P., Irwig, L., Heritier, S. (2008). Monitoring cholesterol-modifying interventions. In P Glasziou, L Irwig and J K Aronson (Eds.), Evidence-based Medical Monitoring:From Principles to Practice, (pp. 245-253). Oxford: Blackwell Publishers.
  • Irwig, L., Healey, P., D'Assuncao, J., Macaskill, P. (2008). Monitoring intraocular pressure in glaucoma. In P Glasziou, L Irwig and J K Aronson (Eds.), Evidence-based Medical Monitoring:From Principles to Practice, (pp. 325-334). Oxford: Blackwell Publishers.
  • Bell, K., Craig, J., Irwig, L. (2008). Monitoring the initial response to treatment. In P Glasziou, L Irwig and J K Aronson (Eds.), Evidence-based Medical Monitoring:From Principles to Practice, (pp. 75-89). Oxford: Blackwell Publishers.
  • Barratt, A., Cumming, R., Irwig, L., Glasziou, P., Guyatt, G., Muir Gray, J., Hicks, N., Raffle, A. (2008). Moving from evidence to action: Recommendations about screening. In Gordon Guyatt & Drummond Rennie (Eds.), Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, (pp. 663-678). United States: American Medical Association.
  • Macaskill, P., Glasziou, P., Irwig, L. (2005). Meta-analysis of Diagnostic Tests. In Peter Armitage and Theodore Colton (Eds.), Encyclopedia of Biostatistics – 2nd Edition, (pp. 3213-3221). John Wiley & Sons.
  • Barratt, A., Irwig, L., Cumming, R., Glasziou, P., Raffle, A., Hicks,, N., Muir, G. (2002). Moving from evidence to action: recommendations about screening. In Gordon Guyatt & Drummond Rennie (Eds.), Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, (pp. 583-597). United States: American Medical Association.
  • Barratt, A., Irwig, L., Glasziou, P., Cumming, R., Raffle, A., Hicks,, N., Gray, J., Guyatt,, G. (2001). Screening. In Pencheon D, Guest C, Melzer D, Muir-Gray (Eds.), Oxford Handbook of Public Health Practice, (pp. 236-243). United Kingdom: Oxford University Press.

Journals

  • Bell, K., Beller, E., Sundstrom, J., McGeechan, K., Hayen, A., Irwig, L., Neal, B., Glasziou, P. (2014). Ambulatory blood pressure adds little to Framingham Risk Score for the primary prevention of cardiovascular disease in older men: secondary analysis of observational study data. BMJ Open, 4(9), 1-9. [More Information]
  • McGeechan, K., Macaskill, P., Irwig, L., Bossuyt, P. (2014). An assessment of the relationship between clinical utility and predictive ability measures and the impact of mean risk in the population. BMC Medical Research Methodology, 14(July), 1-12. [More Information]
  • Bonner, C., Jansen, J., McKinn, S., Irwig, L., Doust, J., Glasziou, P., McCaffery, K. (2014). Communicating cardiovascular disease risk: an interview study of General Practitioners' use of absolute risk within tailored communication strategies. BMC Family Practice, 15(1), 1-8. [More Information]
  • Bell, K., Glasziou, P., Hayen, A., Irwig, L. (2014). Criteria for monitoring tests were described: validity, responsiveness, detectability of long-term change, and practicality. Journal of Clinical Epidemiology, 67(2), 152-159. [More Information]
  • Jansen, J., Bonner, C., McKinn, S., Irwig, L., Glasziou, P., Doust, J., Teixeira-Pinto, A., Hayden, A., Turner, R., McCaffery, K. (2014). General practitioners' use of absolute risk versus individual risk factors in cardiovascular disease prevention: an experimental study. BMJ Open, 4(5), 1-7. [More Information]
  • Bonner, C., Jansen, J., Newell, B., Irwig, L., Glasziou, P., Doust, J., Dhillon, H., McCaffery, K. (2014). I Don't Believe It, But I'd Better Do Something About It: Patient Experiences of Online Heart Age Risk Calculators. Journal of Medical Internet Research, 16(5), 1-17. [More Information]
  • Hersch, J., Jansen, J., Barratt, A., Irwig, L., Houssami, N., Jacklyn, G., Thornton, H., Dhillon, H., McCaffery, K. (2014). Overdetection in breast cancer screening: development and preliminary evaluation of a decision aid. BMJ Open, 4(9), e006016. [More Information]
  • Downie, A., Williams, C., Henschke, N., Hancock, M., Ostelo, R., de Vet, H., Macaskill, P., Irwig, L., Van Tulder, M., Koes, B., Maher, C. (2014). Red flags to screen for malignancy and fracture in patients with low back pain. British Journal of Sports Medicine, 48(20), 1518.
  • Turner, R., Walter, S., Macaskill, P., McCaffery, K., Irwig, L. (2014). Sample size and power when designing a randomized trial for the estimation of treatment, selection, and preference effects. Medical Decision Making: an international journal, 34(6), 711-719. [More Information]
  • Hersch, J., Barratt, A., Jansen, J., Houssami, N., Irwig, L., Jacklyn, G., Dhillon, H., Thornton, H., McGeechan, K., Howard, K., McCaffery, K. (2014). The effect of information about overdetection of breast cancer on women's decision-making about mammography screening: study protocol for a randomised controlled trial. BMJ Open, 4(5), 1-10. [More Information]
  • Glasziou, P., Irwig, L., Kirby, A., Tonkin, A., Simes, R. (2014). Which lipid measurement should we monitor? An analysis of the LIPID study. BMJ Open, 4(2), e003512. [More Information]
  • Rychetnik, L., Carter, S., Barratt, A., Irwig, L. (2013). Expanding the evidence on cancer screening: the value of scientific, social and ethical perspectives. Medical Journal of Australia, 198(10), 536-539. [More Information]
  • Rychetnik, L., McCaffery, K., Morton, R., Thompson, J., Menzies, S., Irwig, L. (2013). Follow-Up of Early Stage Melanoma: Specialist Clinician Perspectives on the Functions of Follow-Up and Implications for Extending Follow-Up Intervals. Journal of Surgical Oncology, 107(5), 463-468. [More Information]
  • Bonner, C., Jansen, J., McKinn, S., Irwig, L., Doust, J., Glasziou, P., Hayen, A., McCaffery, K. (2013). General practitioners' use of different cardiovascular risk assessment strategies: a qualitative study. Medical Journal of Australia, 199(7), 485-489. [More Information]
  • Marinovich, M., Macaskill, P., Irwig, L., Sardanelli, F., von Minckwitz, G., Mamounas, E., Brennan, M., Ciatto, S., Houssami, N. (2013). Meta-analysis of agreement between MRI and pathologic breast tumour size after neoadjuvant chemotherapy. British Journal of Cancer, 109(6), 1528-1536. [More Information]
  • Marinovich, M., Houssami, N., Macaskill, P., Sardanelli, F., Irwig, L., Mamounas, E., von Minckwitz, G., Brennan, M., Ciatto, S. (2013). Meta-Analysis of Magnetic Resonance Imaging in Detecting Residual Breast Cancer After Neoadjuvant Therapy. Journal of the National Cancer Institute, 105(5), 321-333. [More Information]
  • Morton, R., Rychetnik, L., McCaffery, K., Thompson, J., Irwig, L. (2013). Patients' perspectives of long-term follow-up for localised cutaneous melanoma. European Journal of Surgical Oncology, 39, 297-303. [More Information]
  • Rychetnik, L., McCaffery, K., Morton, R., Irwig, L. (2013). Psychosocial aspects of post-treatment follow-up for stage I/II melanoma: a systematic review of the literature. Psycho-Oncology: journal of the psychological, social and behavioral dimensions of cancer, 22(4), 721-736. [More Information]
  • Downie, A., Williams, C., Henschke, N., Hancock, M., Ostelo, R., de Vet, H., Macaskill, P., Irwig, L., van Tulder, M., Koes, B., Maher, C. (2013). Red flags to screen for malignancy and fracture in patients with low back pain: systematic review. BMJ: British Medical Journal, 347, 1-9. [More Information]
  • Henschke, N., Maher, C., Ostelo, R., de Ver, H., Macaskill, P., Irwig, L. (2013). Red flags to screen for malignancy in patients with low-back pain. Cochrane Database of Systematic Reviews, (2), 1-42. [More Information]
  • Williams, C., Henschke, N., Maher, C., van Tulder, M., Koes, B., Macaskill, P., Irwig, L. (2013). Red flags to screen for vertebral fracture in patients presenting with low-back pain. Cochrane Database of Systematic Reviews, 1, 1-56. [More Information]
  • Houssami, N., Abraham, L., Kerlikowske, K., Buist, D., Irwig, L., Lee, J., Miglioretti, D. (2013). Risk Factors for Second Screen-Detected or Interval Breast Cancers in Women with a Personal History of Breast Cancer Participating in Mammography Screening. Cancer Epidemiology, Biomarkers and Prevention, 22(5), 946-961. [More Information]
  • Lucas, N., Macaskill, P., Irwig, L., Moran, R., Rickards, L., Turner, R., Bogduk, N. (2013). The reliability of a quality appraisal tool for studies of diagnostic reliability (QAREL). BMC Medical Research Methodology, 13, 1-6. [More Information]
  • Bell, K., Hayen, A., Irwig, L., Takahashi, O., Ohde, S., Glasziou, P. (2013). When to remeasure cardiovascular risk in untreated people at low and intermediate risk: observational study. BMJ, 346(7906), 1-8. [More Information]
  • Hersch, J., Jansen, J., Barratt, A., Irwig, L., Houssami, N., Howard, K., Dhillon, H., McCaffery, K. (2013). Women's views on overdiagnosis in breast cancer screening: a qualitative study. BMJ, 346(7892), 1-13. [More Information]
  • Hayden, A., Bell, K., Glasziou, P., Irwig, L. (2012). A counterargument to encounter frequency and target achievement: measurement variability. Archives of Internal Medicine, 172(4), 374-375. [More Information]
  • Flitcroft, K., Irwig, L., Carter, S., Salkeld, G., Gillespie, J. (2012). Colorectal cancer screening: Why immunochemical fecal occult blood tests may be the best option. BMC Gastroenterology, 12(December), 1-6. [More Information]
  • Turner, R., Hayen, A., Macaskill, P., Irwig, L., Reddel, H. (2012). Control charts demonstrated limited utility for the monitoring of lung function in asthma. Journal of Clinical Epidemiology, 65(1), 53-61. [More Information]
  • Marinovich, M., Sardanelli, F., Ciatto, S., Mamounas, E., Brennan, M., Macaskill, P., Irwig, L., von Minckwitz, G., Houssami, N. (2012). Early prediction of pathologic response to neoadjuvant therapy in breast cancer: Systematic review of the accuracy of MRI. The Breast, 21(5), 669-677. [More Information]
  • Walter, S., Macaskill, P., Lord, S., Irwig, L. (2012). Effect of dependent errors in the assessment of diagnostic or screening test accuracy when the reference standard is imperfect. Statistics in Medicine, 31(11-12), 1129-1138. [More Information]
  • Bell, K., Hayen, A., McGeechan, K., Neal, B., Irwig, L. (2012). Effects of additional blood pressure and lipid measurements on the prediction of cardiovascular risk. European Journal of Preventive Cardiology, 19(6), 1474-1485. [More Information]
  • Walter, S., Turner, R., Macaskill, P., McCaffery, K., Irwig, L. (2012). Optimal allocation of participants for the estimation of selection, preference and treatment effects in the two-stage randomised trial design. Statistics in Medicine, 31(13), 1307-1322. [More Information]
  • Adelstein, B., Macaskill, P., Turner, R., Irwig, L. (2012). Patients who take their symptoms less seriously are more likely to have colorectal cancer. BMC Gastroenterology, 12, 1-9. [More Information]
  • Rychetnik, L., Morton, R., McCaffery, K., Thompson, J., Menzies, S., Irwig, L. (2012). Shared care in the follow-up of early-stage melanoma: a qualitative study of Australian melanoma clinicians' perspectives and models of care. BMC Health Services Research, 12, 1-9. [More Information]
  • Bell, K., Hayen, A., Irwig, L., Hochberg, M., Ensrud, K., Cummings, S., Bauer, D. (2012). The Potential Value of Monitoring Bone Turnover Markers Among Women on Alendronate. Journal of Bone and Mineral Research, 27(1), 195-201. [More Information]
  • Staub, L., Lord, S., Simes, R., Dyer, S., Houssami, N., Chen, R., Irwig, L. (2012). Using patient management as a surrogate for patient health outcomes in diagnostic test evaluation. BMC Medical Research Methodology, 12, 1-12. [More Information]
  • Houssami, N., Abraham, L., Miglioretti, D., Sickles, E., Kerlikowske, K., Buist, D., Geller, B., Muss, H., Irwig, L. (2011). Accuracy and Outcomes of Screening Mammography in Women With a Personal History of Early-Stage Breast Cancer. JAMA: The Journal of the American Medical Association, 305(8), 790-799. [More Information]
  • McCaffery, K., Turner, R., Macaskill, P., Walter, S., Chan, S., Irwig, L. (2011). Determining the Impact of Informed Choice : Separating Treatment Effects from the Effects of Choice and Selection in Randomized Trials. Medical Decision Making: an international journal, 31(2), 229-236. [More Information]
  • Hersch, J., Jansen, J., Irwig, L., Barratt, A., Thornton, H., Howard, K., McCaffery, K. (2011). How do we achieve informed choice for women considering breast screening? Preventive Medicine, 53(3), 144-146. [More Information]
  • Bell, K., Kirby, A., Hayen, A., Irwig, L., Glasziou, P. (2011). Monitoring adherence to drug treatment by using change in cholesterol concentration: secondary analysis of trial data. BMJ: British Medical Journal, 342(Issue 7791, 29 January 2011, Article number d12), 1-7. [More Information]
  • Adelstein, B., Macaskill, P., Chan, S., Katelaris, P., Irwig, L. (2011). Most bowel cancer symptoms do not indicate colorectal cancer and polyps: a systematic review. BMC Gastroenterology, 11, 65-1-65-10. [More Information]
  • Neal, B., Irwig, L. (2011). Not much need for ambulatory blood pressure monitoring. Medical Journal of Australia, 195(11-12), 634-635. [More Information]
  • Turner, R., Bell, K., Morton, R., Hayen, A., Francken, A., Howard, K., Armstrong, B., Thompson, J., Irwig, L. (2011). Optimizing the Frequency of Follow-Up Visits for Patients Treated for Localized Primary Cutaneous Melanoma. Journal of Clinical Oncology, 29(35), 4641-4646. [More Information]
  • Hersch, J., Jansen, J., Irwig, L., Barratt, A., Thornton, H., Howard, K., McCaffery, K. (2011). Reply to Braillon and Nicot. Preventive Medicine, 53(6), 438-438. [More Information]
  • Lord, S., Staub, L., Bossuyt, P., Irwig, L. (2011). Target practice: choosing target conditions for test accuracy studies that are relevant to clinical practice. BMJ: British Medical Journal, 343(7822), d4684-(5pp). [More Information]
  • Adelstein, B., Macaskill, P., Turner, R., Katelaris, P., Irwig, L. (2011). The value of age and medical history for predicting colorectal cancer and adenomas in people referred for colonoscopy. BMC Gastroenterology, 11(2011), Article number 97-1-Article number 97-10. [More Information]
  • Walter, S., Forbes, A., Chan, S., Macaskill, P., Irwig, L. (2011). When should one adjust for measurement error in baseline variables in observational studies? Biometrical Journal, 53(1), 28-39. [More Information]
  • Hayen, A., Macaskill, P., Irwig, L., Bossuyt, P. (2010). Appropriate statistical methods are required to assess diagnostic tests for replacement, add-on, and triage. Journal of Clinical Epidemiology, 63(8), 883-891. [More Information]
  • Morrell, S., Barratt, A., Irwig, L., Howard, K., Biesheuval, C., Armstrong, B. (2010). Estimates of overdiagnosis of invasive breast cancer associated with screening mammography. Cancer Causes and Control: an international journal of studies of cancer in human populations, 21(2), 275-282. [More Information]
  • Flitcroft, K., Salkeld, G., Gillespie, J., Trevena, L., Irwig, L. (2010). Fifteen years of bowel cancer screening policy in Australia: putting evidence into practice? Medical Journal of Australia, 193(1), 37-42. [More Information]
  • Houssami, N., Macaskill, P., Marinovich, M., Dixon, J., Irwig, L., Brennan, M., Solin, L. (2010). Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy. European Journal of Cancer, 46(18), 3219-3232. [More Information]
  • Hayen, A., Bell, K., Glasziou, P., Neal, B., Irwig, L. (2010). Monitoring Adherence to Medication by Measuring Change in Blood Pressure. Hypertension, 56(4), 612-616. [More Information]
  • Bell, K., Hayen, A., Macaskill, P., Craig, J., Neal, B., Fox, K., Remme, W., Asselbergs, F., van Gilst, W., MacMahon, S., Irwig, L., et al (2010). Monitoring Initial Response to Angiotensin-Converting Enzyme Inhibitor-Based Regimens. An Individual Patient Data Meta-Analysis From Randomized, Placebo-Controlled Trials. Hypertension, 56(3), 533-539. [More Information]
  • McCaffery, K., Irwig, L., Turner, R., Chan, S., Macaskill, P., Lewicka, M., Clarke, J., Weisberg, E., Barratt, A. (2010). Psychosocial outcomes of three triage methods for the management of borderline abnormal cervical smears: an open randomised trial. BMJ: British Medical Journal, 340, b4491-1-b4491-13. [More Information]
  • Bell, K., Irwig, L., Hayen, A., Macaskill, P., Craig, J. (2010). Should response rules be used to decide continued subsidy of very expensive drugs? A checklist for decision makers. Pharmacoepidemiology and drug safety, 19(1), 99-105. [More Information]
  • Craig, J., Williams, G., Jones, M., Codarini, M., Macaskill, P., Hayen, A., Irwig, L., Fitzgerald, D., Isaacs, D., McCaskill, M. (2010). The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses. BMJ: British Medical Journal, 340, c1594-1-c1594-12. [More Information]
  • Lucas, N., Macaskill, P., Irwig, L., Bogduk, N. (2010). The development of a quality appraisal tool for studies of diagnostic reliability (QAREL). Journal of Clinical Epidemiology, 63(8), 854-861. [More Information]
  • Bell, K., Hayen, A., Irwig, L., Macaskill, P., Craig, J., Ensrud, K., Bauer, D. (2010). The Value of Routine BMD Monitoring After Starting Bisphosphonate Treatment. Journal of Bone and Mineral Research, 25(1), 173-174. [More Information]
  • Adelstein, B., Irwig, L., Macaskill, P., Turner, R., Chan, S., Katelaris, P. (2010). Who needs colonoscopy to identify colorectal cancer? Bowel symptoms do not add substantially to age and other medical history. Alimentary Pharmacology and Therapeutics, 32(2), 270-281. [More Information]
  • Craig, J., Simpson, J., Williams, G., Lowe, A., Reynolds, G., McTaggart, S., Hodson, E., Carapetis, J., Cranswick, N., Smith, G., Irwig, L., Caldwell, P., Roy, L., et al (2009). Antibiotic prophylaxis and recurrent urinary tract infection in children. New England Journal of Medicine, 361(18), 1748-1759. [More Information]
  • Leeflang, M., Bossuyt, P., Irwig, L. (2009). Diagnostic test accuracy may vary with prevalence: implications for evidence-based diagnosis. Journal of Clinical Epidemiology, 62(1), 5-12. [More Information]
  • Davey, E., Irwig, L., Macaskill, P., Clarke, J., Thurloe, J., Hyne, S., Biro, C. (2009). Does providing previous results change the accuracy of cervical cytology? Acta Cytologica, 53(6), 644-652. [More Information]
  • Keenan, K., Hayen, A., Neal, B., Irwig, L. (2009). Long term monitoring in patients receiving treatment to lower blood pressure: analysis of data from placebo controlled randomised controlled trial. BMJ: British Medical Journal, 338, 1-7. [More Information]
  • Brennan, M., Houssami, N., Lord, S., Macaskill, P., Irwig, L., Dixon, J., Warren, R., Ciatto, S. (2009). Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management. Journal of Clinical Oncology, 27(33), 5640-5649. [More Information]
  • McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Klein, B., Wang, J., Mitchell, P., Vingerling, J., de Jong, P., et al (2009). Meta-analysis: retinal vessel caliber and risk for coronary heart disease. Annals of Internal Medicine, 151(6), 404-413. [More Information]
  • Bell, K., Hayen, A., Macaskill, P., Craig, J., Neal, B., Irwig, L. (2009). Mixed models showed no need for initial response monitoring after starting antihypertensive therapy. Journal of Clinical Epidemiology, 62, 650-659. [More Information]
  • McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Klein, B., Wang, J., Mitchell, P., Vingerling, J., de Jong, P., et al (2009). Prediction of incident stroke events based on retinal vessel caliber: a systematic review and individual-participant meta-analysis. American Journal of Epidemiology, 170(11), 1323-1332. [More Information]
  • Lucas, N., Macaskill, P., Irwig, L., Moran, R., Bogduk, N. (2009). Reliability of physical examination for diagnosis of myofascial trigger points: A systematic review of the literature. Clinical Journal of Pain, 25(1), 80-89. [More Information]
  • Lord, S., Irwig, L., Bossuyt, P. (2009). Using the principles of randomized controlled trial design to guide test evaluation. Medical Decision Making: an international journal, 29(5), E1-E12. [More Information]
  • Bell, K., Hayen, A., Macaskill, P., Irwig, L., Craig, J., Ensrud, K., Bauer, D. (2009). Value of routine monitoring of bone mineral density after starting bisphosphonate treatment: secondary analysis of trial data. BMJ: British Medical Journal, 338(b2266), b2266-1-b2266-5. [More Information]
  • Adelstein, B., Irwig, L., Macaskill, P., Katelaris, P., Jones, D., Bokey, E. (2008). A self administered reliable questionnaire to assess lower bowel symptoms. BMC Gastroenterology, 8(8), 1-9. [More Information]
  • Houssami, N., Ciatto, S., Macaskill, P., Lord, S., Warren, R., Dixon, J., Irwig, L. (2008). Accuracy and Surgical Impact of Magnetic Resonance Imaging in Breast Cancer Staging: Systematic Review and Meta-Analysis in Detection of Multifocal and Multicentric Cancer. Journal of Clinical Oncology, 26(19), 3248-3258. [More Information]
  • McGeechan, K., Macaskill, P., Irwig, L., Liew, G., Wong, T. (2008). Assessing New Biomarkers and Predictive Models for Use in Clinical Practice. Archives of Internal Medicine, 168(21), 2304-2310. [More Information]
  • Hewitson, P., Glasziou, P., Watson, E., Towler, B., Irwig, L. (2008). Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update. American Journal of Gastroenterology, 103(6), 1541-1549. [More Information]
  • Entwistle, V., Carter, S., Trevena, L., Flitcroft, K., Irwig, L., McCaffery, K., Salkeld, G. (2008). Communicating about screening. BMJ: British Medical Journal, 337(7673), 789-791. [More Information]
  • Craig, J., Webster, A., Mitchell, A., Irwig, L. (2008). Expanding the Evidence Base in Transplantation: More and Better Randomized Trials, and Extending the Value of Observational Data. Transplantation, 86(1), 32-35. [More Information]
  • McCaffery, K., Irwig, L., Chan, S., Macaskill, P., Barratt, A., Lewicka, M., Clarke, J., Weisberg, E. (2008). HPV testing versus repeat Pap testing for the management of a minor abnormal Pap smear: Evaluation of a decision aid to support informed choice. Patient Education and Counseling, 73(3), 473-481. [More Information]
  • Turner, M., van Schalkwyk, J., Irwig, L. (2008). Lax sphygmomanometer standard causes overdetection and underdetection of hypertension: a computer simulation study. Blood pressure monitoring, 13(2), 91-99. [More Information]
  • Glasziou, P., Irwig, L., Heritier, S., Simes, R., Tonkin, A. (2008). Monitoring cholesterol levels: Measurement error or true change? Annals of Internal Medicine, 148(9), 656-661. [More Information]
  • Trevena, L., Irwig, L., Barratt, A. (2008). Randomized trial of a self-administered decision aid for colorectal cancer screening. Journal of Medical Screening, 15(2), 76-81. [More Information]
  • McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Sharrett, A., Klein, B., Wang, J., Chambless, L., Wong, T. (2008). Risk Prediction of Coronary Heart Disease Based on Retinal Vascular Caliber (from the Atherosclerosis Risk In Communities [ARIC] Study). The American Journal of Cardiology, 102(1), 58-63. [More Information]
  • Leeflang, M., Deeks, J., Gastonis, C., Bossuyt, P., Irwig, L., Craig, J. (2008). Systematic reviews of diagnostic test accuracy. Annals of Internal Medicine, 149(12), 889-897.
  • Chan, S., Deeks, J., Macaskill, P., Irwig, L. (2008). Three methods to construct predictive models using logistic regression and likelihood ratios to facilitate adjustment for pretest probability give similar results. Journal of Clinical Epidemiology, 61(1), 52-63. [More Information]
  • Bell, K., Irwig, L., Craig, J., Macaskill, P. (2008). Use of randomised trials to decide when to monitor response to new treatment. BMJ: British Medical Journal, 336, 361-365. [More Information]
  • Glasziou, P., Irwig, L., Deeks, J. (2008). When should a new test become the current reference standard? Annals of Internal Medicine, 149(11), 816-821. [More Information]
  • Lord, S., Irwig, L., Simes, R. (2007). A philosophical approach to diagnostic test evaluation - In Response. Annals of Internal Medicine, 146(10), 757-758.
  • Davey, E., D'Assuncao, J., Irwig, L., Macaskill, P., Chan, S., Richards, A., Farnsworth, A. (2007). Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study. BMJ: British Medical Journal, 335(7609), 31-39. [More Information]
  • Irwig, L., Macaskill, P., Chan, S., D'Assuncao, J., Richards, A., Farnsworth, A. (2007). Cervical cytology reading times: A comparison between thinprep imager and conventional methods. Diagnostic Cytopathology, 35(9), 550-4. [More Information]
  • Biesheuvel, C., Barratt, A., Howard, K., Houssami, N., Irwig, L. (2007). Effects of study methods and biases on estimates of invasive breast cancer overdetection with mammography screening: a systematic review. Lancet Oncology, 8(12), 1129-1138. [More Information]
  • Trevena, L., Irwig, L., Isaacs, A., Barratt, A. (2007). GPs want tailored, user friendly evidence summaries--a cross sectional study in New South Wales. Australian Family Physician, 36(12), 1065-1069. [More Information]
  • Howard, K., Salkeld, G., McCaffery, K., Irwig, L. (2007). HPV triage testing or repeat Pap smear for the management of atypical squamous cells (ASCUS) on Pap smear: is there evidence of process utility? Health Economics, Published Online: Sep 3 2007, 1-13. [More Information]
  • Biesheuval, C., Irwig, L., Bossuyt, P. (2007). Observed Differences in Diagnostic Test Accuracy between Patient Subgroups: Is It Real or Due to Reference Standard Misclassification? Clinical Chemistry (Washington, DC), 53(10), 1725-1729. [More Information]
  • McCaffery, K., Irwig, L., Bossuyt, P. (2007). Patient Decision Aids to Support Clinical Decision Making: Evaluating the Decision or the Outcomes of the Decision. Medical Decision Making: an international journal, 27(5), 619-625. [More Information]
  • Irwig, L., Irwig, J., Trevena, L., Sweet, M. (2007). Smart Health Choice Essentials. Evidence-Based Medicine, 12(6), 164-166.
  • Bossuyt, P., Reitsma, J., Bruns, D., Gatsonis, C., Glasziou, P., Irwig, L., Lijmer, J., Moher, D., Rennie, D., de Vet, H. (2007). Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Veterinary Clinical Pathology, 36(1), 8-12.
  • Bossuyt, P., Irwig, L., Craig, J., Glasziou, P. (2006). Comparative accuracy: assessing new tests against existing diagnostic pathways. British Medical Journal, 332(7549), 1089-92. [More Information]
  • Bossuyt, P., Irwig, L., Craig, J., Glasziou, P. (2006). Diagnosis - Comparative accuracy: assessing new tests against existing diagnostic pathways. BMJ: British Medical Journal, 332(7549), 1089-1092.
  • Davey, E., Barratt, A., Irwig, L., Chan, S., Macaskill, P., Mannes, P., Saville, A. (2006). Effect of study design and quality on unsatisfactory rates, cytology classifications, and accuracy in liquid-based versus conventional cervical cytology: a systematic review. The Lancet, 367(9505), 122-132. [More Information]
  • Irwig, L., Houssami, N., Armstrong, B., Glasziou, P. (2006). Evaluating new screening tests for breast cancer. BMJ: British Medical Journal, 332(7543), 678-679. [More Information]
  • Trevena, L., Irwig, L., Barratt, A. (2006). Impact of privacy legislation on the number and characteristics of people who are recruited for research: a randomised controlled trial. Journal of Medical Ethics, 32(8), 473-477. [More Information]
  • Irwig, L., McCaffery, K., Salkeld, G., Bossuyt, P. (2006). Informed choice for screening: implications for evaluation. BMJ: British Medical Journal, 332(7550), 1148-1150. [More Information]
  • Jabbour, J., Irwig, L., Macaskill, P., Hennessy, M. (2006). Intraocular lens power in bilateral cataract surgery: Whether adjusting for error of predicted refraction in the first eye improves prediction in the second eye. Journal of Cataract and Refractive Surgery, 32(12), 2091-2097. [More Information]
  • Turner, M., Irwig, L., Bune, A., Kam, P., Baker, A. (2006). Lack of sphygmomanometer calibration causes over- and under-detection of hypertension: a computer simulation study. Journal of Hypertension, 24(10), 1931-1938. [More Information]
  • Irwig, L., Macaskill, P., Walter, S., Houssami, N. (2006). New methods give better estimates of changes in diagnostic accuracy when prior information is provided. Journal of Clinical Epidemiology, 59(3), 299-307. [More Information]
  • Houssami, N., Irwig, L., Ciatto, S. (2006). Radiological surveillance of interval breast cancers in screening programmes. Lancet Oncology, 7(3), 259-265. [More Information]
  • Chan, S., Macaskill, P., Irwig, L., Walter, S. (2006). Re: In response to the correspondence arising from Twisk and Proper: evaluation of the results of a randomized controlled trial: how to define changes between baseline and follow-up. Journal of Clinical Epidemiology, 59(3), 323-323.
  • Lord, S., Irwig, L., Simes, R. (2006). When is measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized trials? Annals of Internal Medicine, 144(11), 850-855. [More Information]
  • McCaffery, K., Irwig, L. (2005). Australian women's needs and preferences for information about human papillomavirus in cervical screening. Journal of Medical Screening, 12(3), 134-41. [More Information]
  • Houssami, N., Ciatto, S., Ambrogetti, D., Catarzi, S., Risso, G., Bonardi, R., Irwig, L. (2005). Florence-Sydney Breast Biopsy Study: sensitivity of ultrasound-guided versus freehand fine needle biopsy of palpable breast cancer. Breast Cancer Research and Treatment, 89(1), 55-59. [More Information]
  • Howard, K., Salkeld, G., Irwig, L., Adelstein, B. (2005). High participation rates are not necessary for cost-effective colorectal cancer screening. Journal of Medical Screening, 12(2), 96-102. [More Information]
  • Tew, K., Irwig, L., Matthews, A., Crowe, P., Macaskill, P. (2005). Meta-analysis of sentinel node imprint cytology in breast cancer. British Journal of Surgery, 92(9), 1068-1080. [More Information]
  • Barratt, A., Howard, K., Irwig, L., Houssami, N. (2005). Model of outcomes of screening mammography - Authors' reply. British Medical Journal, 331(7512), 351-351.
  • Barratt, A., Howard, K., Irwig, L., Salkeld, G., Houssami, N. (2005). Model of outcomes of screening mammography: Author’s reply. BMJ: British Medical Journal, 331(7512), 351.
  • Barratt, A., Howard, K., Irwig, L., Salkeld, G., Houssami, N. (2005). Model of outcomes of screening mammography: information to support informed choices. BMJ: British Medical Journal, 330(7497), 936-940. [More Information]
  • Glasziou, P., Irwig, L., Mant, D. (2005). Monitoring in chronic disease: A rational approach. British Medical Journal, 330, 644-648.
  • Houssami, N., Irwig, L., Ung, O. (2005). Review of complex breast cysts: Implications for cancer detection and clinical practice. ANZ Journal of Surgery, 75(12), 1080-1085.
  • Houssami, N., Irwig, L., Simpson, J., McKessar, M., Blome, S., Noakes, J. (2005). The Influence of Knowledge of Mammography Findings on the Accuracy of Breast Ultrasound in Symptomatic Women. The Breast Journal, 11(3), 167-172. [More Information]
  • Deeks, J., Macaskill, P., Irwig, L. (2005). The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. Journal of Clinical Epidemiology, 58(9), 882-893. [More Information]
  • Irwig, L., Macaskill, P., Farnsworth, A., Wright, R., McCool, J., Barratt, A., Simpson, J. (2004). A randomized crossover trial of PAPNET for primary cervical screening. Journal of Clinical Epidemiology, 57(1), 75-81.
  • Loy, C., Irwig, L. (2004). Accuracy Of Diagnostic Tests Read With And Without Clinical Information: A Systematic Review. JAMA: The Journal of the American Medical Association, 292(13), 1602-1609. [More Information]
  • Chan, S., Macaskill, P., Irwig, L., Walter, S. (2004). Adjustment For Baseline Measurement Error In Randomized Controlled Trials Induces Bias. Contemporary Clinical Trials, 25(4), 408-416. [More Information]
  • Bakis, S., Irwig, L., Wood, G., Wong, D. (2004). Exfoliative Cytology As A Diagnostic Test For Basal Cell Carcinoma: A Meta-Analysis. British Journal of Dermatology, 150(8), 829-836.
  • Irwig, L., Houssami, N., Van Vliet, C. (2004). New Technologies In Screening For Breast Cancer: A Systematic Review Of Their Accuracy. British Journal of Cancer, 90(11), 2118-2122.
  • Irwig, L., Houssami, N., Simpson, J., McKessar, M., Blome, S., Noakes, J. (2004). The Influence Of Clinical Information On The Accuracy Of Diagnostic Mammography. Breast Cancer Research and Treatment, 85(3), 223-238.
  • Marschner, C., Emberson, J., Irwig, L., Walter, S. (2004). The Number Needed To Treat (Nnt) Can Be Adjusted For Bias When The Outcome Is Measured With Error. Journal of Clinical Epidemiology, 57(12), 1244-1242. [More Information]
  • Chen, J., Conigrave, K., Macaskill, P., Whitfield, J., Irwig, L. (2003). Combining carbohydrate-deficient transferrin and gamma-glutamyltransferase to increase diagnostic accuracy for problem drinking. Alcohol and Alcoholism, 38(6), 574-582.
  • Askie, L., Henderson-Smart, D., Irwig, L., Simpson, J. (2003). Oxygen-saturation targets and outcomes in extremely preterm infants. New England Journal of Medicine, 349, 959-967.
  • Houssami, N., Irwig, L., Simpson, J., McKessar, M., Blome, S., Noakes, J. (2003). Sydney breast imaging accuracy study: comparative sensitivity and specificity of mammography and sonography in young women with symptoms. American Journal Of Roentgenology, 180(4), 935-940.
  • Houssami, N., Irwig, L., Simpson, J., McKessar, M., Blome, S., Noakes, J. (2003). The contribution of work-up or additional views to the accuracy of diagnostic mammography. The Breast, 12(4), 270-275.
  • Bossuyt, P., Reitsma, J., Bruns, D., Gatsonis, C., Glasziou, P., Irwig, L., Moher, D., Rennie, D., de Vet, H., Lijmer, J. (2003). The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clinical Chemistry (Washington, DC), 49(1), 7-18.
  • Bossuyt, P., Reitsma, J., Bruns, D., Gatsonis, C., Glasziou, P., Irwig, L., Lijmer, J., Moher, D., Rennie, D., de Vet, H. (2003). Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Clinical Chemistry (Washington, DC), 49(1), 1-6.
  • Houssami, N., Irwig, L., Loy, C. (2002). Accuracy of combined breast imaging in young women. The Breast, 11(1), 36-40.
  • Berry, G., Smith, C., Macaskill, P., Irwig, L. (2002). Analytic methods for comparing two dichotomous screening or diagnostic tests applied to two populations of differing disease prevalence when individuals negative on both tests are unverified. Statistics in Medicine, 21(6), 853-862. [More Information]
  • Macaskill, P., Walter, S., Irwig, L., Franco, E. (2002). Assessing the gain in diagnostic performance when combining two diagnostic tests. Statistics in Medicine, 21(17), 2527-2546. [More Information]
  • Barratt, A., Irwig, L., Glasziou, P., Salkeld, G., Houssami, N. (2002). Benefits, harms and costs of screening mammography in women 70 years and over: a systematic review. Medical Journal of Australia, 176(6), 266-271.
  • Barratt, A., Mannes, P., Irwig, L., Trevena, L., Craig, J., Rychetnik, L. (2002). Cancer screening. Journal of Epidemiology and Community Health, 56(12), 899-902.
  • Barratt, A., Mannes, P., Irwig, L., Trevena, L., Craig, J., Rychetnik, L. (2002). Cancer Screening. Journal of Epidemiology and Community Health, 56(12), 899-902. [More Information]
  • Irwig, L., Bossuyt, P., Glasziou, P., Gatsonis,, C., Lijmer,, J. (2002). Designing studies to ensure that estimates of test accuracy are transferable. BMJ: British Medical Journal, , 669-671.
  • Irwig, L., Macaskill, P., Houssami, N. (2002). Evidence relevant to the investigation of breast symptoms: the triple test. The Breast, 11(3), 215-220.
  • Craig, J., Barratt, A., Cumming, R., Irwig, L., Salkeld, G. (2002). Feasibility study of the early detection and treatment of renal disease by mass screening. Internal Medicine Journal, 32(1-2), 6-14.
  • Poynten, I., Hanlon, M., Irwig, L., Gilbert, G. (2002). Serological diagnosis of pertussis: evaluation of IgA against whole cell and specific Bordetella pertussis antigens as markers of recent infection. Epidemiology and Infection, 128(2), 161-167.
  • Houssami, N., Ciatto, S., Irwig, L., Simpson, J., Macaskill, P. (2002). The comparative sensitivity of mammography and ultrasound in women with breast symptoms: an age specific analysis. The Breast, 11(2), 125-130.
  • Macaskill, P., Irwig, L., Walter Stephen, D. (2001). A comparison of methods to detect publication bias in meta-analysis. Statistics in Medicine, 20, 641-654.
  • Irwig, L., Walter Stephen, D. (2001). Estimating the number needed to treat (NNT) index when the data are subject to error. Statistics in Medicine, 20, 893-906.
  • Craig, J., Irwig, L., Stockler, M. (2001). Evidence-based medicine: useful tools for decision making. Medical Journal of Australia, 174, 248-253.
  • Craig, J., Irwig, L., Knight, J., Roy, L. (2000). Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease due to reflux nephropathy? Pediatrics, 105(6), 1236-1241. [More Information]
  • Craig, J., Wheeler, D., Irwig, L., Howman-Giles, R. (2000). How accurate is dimercaptosuccinic acid (DMSA) scintigraphy for the diagnosis of acute pyelonephritis? A meta-analysis of experimental studies. The Journal of Nuclear Medicine, 41(6), 986-993.
  • Craig, J., Irwig, L., Ford, M., Willis, N., Howman-Giles, R., Uren, R., Rossleigh, M., Grunewald, S. (2000). Reliability of DMSA for the diagnosis of renal parenchymal abnormality in children. European Journal of Nuclear Medicine and Molecular Imaging, 27(11), 1610-1616. [More Information]
  • Scouller, K., Conigrave, K., Macaskill, P., Irwig, L., Whitfield, J. (2000). Should we use carbohydrate-deficient transferrin instead of gamma-glutamyltransferase for detecting problem drinkers? A systematic review and metaanalysis. Clinical Chemistry (Washington, DC), 46, 1894-1902.

Conferences

  • Irwig, L. (2006). Is evidence overrated? An international symposium on the nature, purposes, ethics and politics of evidence in a democracy: Keynote Address. Academy of Science of South Africa (ASSAF) 2006, Pretoria, South Africa: Academy of Science of South Africa.
  • Trevena, L., Barratt, A., Irwig, L. (2005). Applying population level evidence with individual patients: An HRT decision aid example. 3rd International Conference of Evidence-Based Healthcare Teachers and Developers. BMJ Publications.
  • Turner, M., Irwig, L., Bune, A., Baker, A., Kam, P. (2005). Lack of sphygmomanometer calibration causes over- and under-detection of hypertension. 6th Biennial Conference of The Metrology Society of Australia.
  • Trevena, L., Irwig, L., Barratt, A. (2005). The impact of privacy legislation on the characteristics of people who are recruited for research: a randomised controlled trial. NHMRC Ethics in Human Research Conference, Australia: NHMRC: National Health and Medical ResearchCouncil.
  • Trevena, L., Irwig, L., Barratt, A. (2004). A general practice-based randomised trial of a decision aid for colorectal cancer screening. 2nd Conference for the European Association of Communication in Healthcare. (IEEE) Institute of Electrical and Electronics Engineers.
  • Codarini, M., Williams, G., Chan, S., Craig, J., Irwig, L., Macaskill, P., McCaskill, M. (2004). Outcomes for children with fever presenting to a Paediatric Emergency Department. Royal Australasian College of Physicians Annual Scientific Meeting. British Medical Journal Publishing Group.
  • Trevena, L., Barratt, A., Irwig, L. (2003). New approaches to preference elicitation, estimation and representation of probabilistic screening information within a home-based decision aid for colorectal cancer screening in general practice. 2nd International Shared Decision Making Conference.
  • Trevena, L., Irwig, L., Barratt, A. (2002). The art and science of clinical decision making in general practice: the development of a decision aid for colorectal cancer screening decisions. GP & PHC Research Conference, 2002, Adelaide: Primary Health Care Research and Information Service.
  • Craig, J., Irwig, L., Stockler, M., Barratt, A., Cumming, R., Caplehorn, J. (2001). Clinical epidemiology education: to help culture change now and generate new research later. 4th International Conference on the Scientific Basis of Health Services.
  • Williams, G., Craig, J., Irwig, L. (2001). Test performance of urinalysis and urine microscopy for the diagnosis of urinary tract infection in children: a meta-analysis. Westmead Association, Not Published: Not Published.

Magazine / Newspaper Articles

  • Trevena, L., Barratt, A., McCaffery, K., Irwig, L. (2003). More haste less speed in the implementation of screening decision aids. BMJ Rapid Response.

Report

  • Craig, J., Howman-Giles, R., Irwig, L., Wheeler, D., Williams, G. (2002). A critical appraisal of the evaluation of children with urinary tract infection (UTI) by diagnostic imaging.

2014

  • Bell, K., Beller, E., Sundstrom, J., McGeechan, K., Hayen, A., Irwig, L., Neal, B., Glasziou, P. (2014). Ambulatory blood pressure adds little to Framingham Risk Score for the primary prevention of cardiovascular disease in older men: secondary analysis of observational study data. BMJ Open, 4(9), 1-9. [More Information]
  • McGeechan, K., Macaskill, P., Irwig, L., Bossuyt, P. (2014). An assessment of the relationship between clinical utility and predictive ability measures and the impact of mean risk in the population. BMC Medical Research Methodology, 14(July), 1-12. [More Information]
  • Bonner, C., Jansen, J., McKinn, S., Irwig, L., Doust, J., Glasziou, P., McCaffery, K. (2014). Communicating cardiovascular disease risk: an interview study of General Practitioners' use of absolute risk within tailored communication strategies. BMC Family Practice, 15(1), 1-8. [More Information]
  • Bell, K., Glasziou, P., Hayen, A., Irwig, L. (2014). Criteria for monitoring tests were described: validity, responsiveness, detectability of long-term change, and practicality. Journal of Clinical Epidemiology, 67(2), 152-159. [More Information]
  • Jansen, J., Bonner, C., McKinn, S., Irwig, L., Glasziou, P., Doust, J., Teixeira-Pinto, A., Hayden, A., Turner, R., McCaffery, K. (2014). General practitioners' use of absolute risk versus individual risk factors in cardiovascular disease prevention: an experimental study. BMJ Open, 4(5), 1-7. [More Information]
  • Bonner, C., Jansen, J., Newell, B., Irwig, L., Glasziou, P., Doust, J., Dhillon, H., McCaffery, K. (2014). I Don't Believe It, But I'd Better Do Something About It: Patient Experiences of Online Heart Age Risk Calculators. Journal of Medical Internet Research, 16(5), 1-17. [More Information]
  • Hersch, J., Jansen, J., Barratt, A., Irwig, L., Houssami, N., Jacklyn, G., Thornton, H., Dhillon, H., McCaffery, K. (2014). Overdetection in breast cancer screening: development and preliminary evaluation of a decision aid. BMJ Open, 4(9), e006016. [More Information]
  • Downie, A., Williams, C., Henschke, N., Hancock, M., Ostelo, R., de Vet, H., Macaskill, P., Irwig, L., Van Tulder, M., Koes, B., Maher, C. (2014). Red flags to screen for malignancy and fracture in patients with low back pain. British Journal of Sports Medicine, 48(20), 1518.
  • Turner, R., Walter, S., Macaskill, P., McCaffery, K., Irwig, L. (2014). Sample size and power when designing a randomized trial for the estimation of treatment, selection, and preference effects. Medical Decision Making: an international journal, 34(6), 711-719. [More Information]
  • Hersch, J., Barratt, A., Jansen, J., Houssami, N., Irwig, L., Jacklyn, G., Dhillon, H., Thornton, H., McGeechan, K., Howard, K., McCaffery, K. (2014). The effect of information about overdetection of breast cancer on women's decision-making about mammography screening: study protocol for a randomised controlled trial. BMJ Open, 4(5), 1-10. [More Information]
  • Glasziou, P., Irwig, L., Kirby, A., Tonkin, A., Simes, R. (2014). Which lipid measurement should we monitor? An analysis of the LIPID study. BMJ Open, 4(2), e003512. [More Information]

2013

  • Rychetnik, L., Carter, S., Barratt, A., Irwig, L. (2013). Expanding the evidence on cancer screening: the value of scientific, social and ethical perspectives. Medical Journal of Australia, 198(10), 536-539. [More Information]
  • Rychetnik, L., McCaffery, K., Morton, R., Thompson, J., Menzies, S., Irwig, L. (2013). Follow-Up of Early Stage Melanoma: Specialist Clinician Perspectives on the Functions of Follow-Up and Implications for Extending Follow-Up Intervals. Journal of Surgical Oncology, 107(5), 463-468. [More Information]
  • Bonner, C., Jansen, J., McKinn, S., Irwig, L., Doust, J., Glasziou, P., Hayen, A., McCaffery, K. (2013). General practitioners' use of different cardiovascular risk assessment strategies: a qualitative study. Medical Journal of Australia, 199(7), 485-489. [More Information]
  • Marinovich, M., Macaskill, P., Irwig, L., Sardanelli, F., von Minckwitz, G., Mamounas, E., Brennan, M., Ciatto, S., Houssami, N. (2013). Meta-analysis of agreement between MRI and pathologic breast tumour size after neoadjuvant chemotherapy. British Journal of Cancer, 109(6), 1528-1536. [More Information]
  • Marinovich, M., Houssami, N., Macaskill, P., Sardanelli, F., Irwig, L., Mamounas, E., von Minckwitz, G., Brennan, M., Ciatto, S. (2013). Meta-Analysis of Magnetic Resonance Imaging in Detecting Residual Breast Cancer After Neoadjuvant Therapy. Journal of the National Cancer Institute, 105(5), 321-333. [More Information]
  • Morton, R., Rychetnik, L., McCaffery, K., Thompson, J., Irwig, L. (2013). Patients' perspectives of long-term follow-up for localised cutaneous melanoma. European Journal of Surgical Oncology, 39, 297-303. [More Information]
  • Rychetnik, L., McCaffery, K., Morton, R., Irwig, L. (2013). Psychosocial aspects of post-treatment follow-up for stage I/II melanoma: a systematic review of the literature. Psycho-Oncology: journal of the psychological, social and behavioral dimensions of cancer, 22(4), 721-736. [More Information]
  • Downie, A., Williams, C., Henschke, N., Hancock, M., Ostelo, R., de Vet, H., Macaskill, P., Irwig, L., van Tulder, M., Koes, B., Maher, C. (2013). Red flags to screen for malignancy and fracture in patients with low back pain: systematic review. BMJ: British Medical Journal, 347, 1-9. [More Information]
  • Henschke, N., Maher, C., Ostelo, R., de Ver, H., Macaskill, P., Irwig, L. (2013). Red flags to screen for malignancy in patients with low-back pain. Cochrane Database of Systematic Reviews, (2), 1-42. [More Information]
  • Williams, C., Henschke, N., Maher, C., van Tulder, M., Koes, B., Macaskill, P., Irwig, L. (2013). Red flags to screen for vertebral fracture in patients presenting with low-back pain. Cochrane Database of Systematic Reviews, 1, 1-56. [More Information]
  • Houssami, N., Abraham, L., Kerlikowske, K., Buist, D., Irwig, L., Lee, J., Miglioretti, D. (2013). Risk Factors for Second Screen-Detected or Interval Breast Cancers in Women with a Personal History of Breast Cancer Participating in Mammography Screening. Cancer Epidemiology, Biomarkers and Prevention, 22(5), 946-961. [More Information]
  • Lucas, N., Macaskill, P., Irwig, L., Moran, R., Rickards, L., Turner, R., Bogduk, N. (2013). The reliability of a quality appraisal tool for studies of diagnostic reliability (QAREL). BMC Medical Research Methodology, 13, 1-6. [More Information]
  • Bell, K., Hayen, A., Irwig, L., Takahashi, O., Ohde, S., Glasziou, P. (2013). When to remeasure cardiovascular risk in untreated people at low and intermediate risk: observational study. BMJ, 346(7906), 1-8. [More Information]
  • Hersch, J., Jansen, J., Barratt, A., Irwig, L., Houssami, N., Howard, K., Dhillon, H., McCaffery, K. (2013). Women's views on overdiagnosis in breast cancer screening: a qualitative study. BMJ, 346(7892), 1-13. [More Information]

2012

  • Hayden, A., Bell, K., Glasziou, P., Irwig, L. (2012). A counterargument to encounter frequency and target achievement: measurement variability. Archives of Internal Medicine, 172(4), 374-375. [More Information]
  • Flitcroft, K., Irwig, L., Carter, S., Salkeld, G., Gillespie, J. (2012). Colorectal cancer screening: Why immunochemical fecal occult blood tests may be the best option. BMC Gastroenterology, 12(December), 1-6. [More Information]
  • Turner, R., Hayen, A., Macaskill, P., Irwig, L., Reddel, H. (2012). Control charts demonstrated limited utility for the monitoring of lung function in asthma. Journal of Clinical Epidemiology, 65(1), 53-61. [More Information]
  • Marinovich, M., Sardanelli, F., Ciatto, S., Mamounas, E., Brennan, M., Macaskill, P., Irwig, L., von Minckwitz, G., Houssami, N. (2012). Early prediction of pathologic response to neoadjuvant therapy in breast cancer: Systematic review of the accuracy of MRI. The Breast, 21(5), 669-677. [More Information]
  • Walter, S., Macaskill, P., Lord, S., Irwig, L. (2012). Effect of dependent errors in the assessment of diagnostic or screening test accuracy when the reference standard is imperfect. Statistics in Medicine, 31(11-12), 1129-1138. [More Information]
  • Bell, K., Hayen, A., McGeechan, K., Neal, B., Irwig, L. (2012). Effects of additional blood pressure and lipid measurements on the prediction of cardiovascular risk. European Journal of Preventive Cardiology, 19(6), 1474-1485. [More Information]
  • Walter, S., Turner, R., Macaskill, P., McCaffery, K., Irwig, L. (2012). Optimal allocation of participants for the estimation of selection, preference and treatment effects in the two-stage randomised trial design. Statistics in Medicine, 31(13), 1307-1322. [More Information]
  • Adelstein, B., Macaskill, P., Turner, R., Irwig, L. (2012). Patients who take their symptoms less seriously are more likely to have colorectal cancer. BMC Gastroenterology, 12, 1-9. [More Information]
  • Rychetnik, L., Morton, R., McCaffery, K., Thompson, J., Menzies, S., Irwig, L. (2012). Shared care in the follow-up of early-stage melanoma: a qualitative study of Australian melanoma clinicians' perspectives and models of care. BMC Health Services Research, 12, 1-9. [More Information]
  • Bell, K., Hayen, A., Irwig, L., Hochberg, M., Ensrud, K., Cummings, S., Bauer, D. (2012). The Potential Value of Monitoring Bone Turnover Markers Among Women on Alendronate. Journal of Bone and Mineral Research, 27(1), 195-201. [More Information]
  • Staub, L., Lord, S., Simes, R., Dyer, S., Houssami, N., Chen, R., Irwig, L. (2012). Using patient management as a surrogate for patient health outcomes in diagnostic test evaluation. BMC Medical Research Methodology, 12, 1-12. [More Information]

2011

  • Houssami, N., Abraham, L., Miglioretti, D., Sickles, E., Kerlikowske, K., Buist, D., Geller, B., Muss, H., Irwig, L. (2011). Accuracy and Outcomes of Screening Mammography in Women With a Personal History of Early-Stage Breast Cancer. JAMA: The Journal of the American Medical Association, 305(8), 790-799. [More Information]
  • McCaffery, K., Turner, R., Macaskill, P., Walter, S., Chan, S., Irwig, L. (2011). Determining the Impact of Informed Choice : Separating Treatment Effects from the Effects of Choice and Selection in Randomized Trials. Medical Decision Making: an international journal, 31(2), 229-236. [More Information]
  • Hersch, J., Jansen, J., Irwig, L., Barratt, A., Thornton, H., Howard, K., McCaffery, K. (2011). How do we achieve informed choice for women considering breast screening? Preventive Medicine, 53(3), 144-146. [More Information]
  • Bell, K., Kirby, A., Hayen, A., Irwig, L., Glasziou, P. (2011). Monitoring adherence to drug treatment by using change in cholesterol concentration: secondary analysis of trial data. BMJ: British Medical Journal, 342(Issue 7791, 29 January 2011, Article number d12), 1-7. [More Information]
  • Adelstein, B., Macaskill, P., Chan, S., Katelaris, P., Irwig, L. (2011). Most bowel cancer symptoms do not indicate colorectal cancer and polyps: a systematic review. BMC Gastroenterology, 11, 65-1-65-10. [More Information]
  • Neal, B., Irwig, L. (2011). Not much need for ambulatory blood pressure monitoring. Medical Journal of Australia, 195(11-12), 634-635. [More Information]
  • Turner, R., Bell, K., Morton, R., Hayen, A., Francken, A., Howard, K., Armstrong, B., Thompson, J., Irwig, L. (2011). Optimizing the Frequency of Follow-Up Visits for Patients Treated for Localized Primary Cutaneous Melanoma. Journal of Clinical Oncology, 29(35), 4641-4646. [More Information]
  • Hersch, J., Jansen, J., Irwig, L., Barratt, A., Thornton, H., Howard, K., McCaffery, K. (2011). Reply to Braillon and Nicot. Preventive Medicine, 53(6), 438-438. [More Information]
  • Lord, S., Staub, L., Bossuyt, P., Irwig, L. (2011). Target practice: choosing target conditions for test accuracy studies that are relevant to clinical practice. BMJ: British Medical Journal, 343(7822), d4684-(5pp). [More Information]
  • Adelstein, B., Macaskill, P., Turner, R., Katelaris, P., Irwig, L. (2011). The value of age and medical history for predicting colorectal cancer and adenomas in people referred for colonoscopy. BMC Gastroenterology, 11(2011), Article number 97-1-Article number 97-10. [More Information]
  • Walter, S., Forbes, A., Chan, S., Macaskill, P., Irwig, L. (2011). When should one adjust for measurement error in baseline variables in observational studies? Biometrical Journal, 53(1), 28-39. [More Information]

2010

  • Hayen, A., Macaskill, P., Irwig, L., Bossuyt, P. (2010). Appropriate statistical methods are required to assess diagnostic tests for replacement, add-on, and triage. Journal of Clinical Epidemiology, 63(8), 883-891. [More Information]
  • Morrell, S., Barratt, A., Irwig, L., Howard, K., Biesheuval, C., Armstrong, B. (2010). Estimates of overdiagnosis of invasive breast cancer associated with screening mammography. Cancer Causes and Control: an international journal of studies of cancer in human populations, 21(2), 275-282. [More Information]
  • Flitcroft, K., Salkeld, G., Gillespie, J., Trevena, L., Irwig, L. (2010). Fifteen years of bowel cancer screening policy in Australia: putting evidence into practice? Medical Journal of Australia, 193(1), 37-42. [More Information]
  • Houssami, N., Macaskill, P., Marinovich, M., Dixon, J., Irwig, L., Brennan, M., Solin, L. (2010). Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy. European Journal of Cancer, 46(18), 3219-3232. [More Information]
  • Hayen, A., Bell, K., Glasziou, P., Neal, B., Irwig, L. (2010). Monitoring Adherence to Medication by Measuring Change in Blood Pressure. Hypertension, 56(4), 612-616. [More Information]
  • Bell, K., Hayen, A., Macaskill, P., Craig, J., Neal, B., Fox, K., Remme, W., Asselbergs, F., van Gilst, W., MacMahon, S., Irwig, L., et al (2010). Monitoring Initial Response to Angiotensin-Converting Enzyme Inhibitor-Based Regimens. An Individual Patient Data Meta-Analysis From Randomized, Placebo-Controlled Trials. Hypertension, 56(3), 533-539. [More Information]
  • McCaffery, K., Irwig, L., Turner, R., Chan, S., Macaskill, P., Lewicka, M., Clarke, J., Weisberg, E., Barratt, A. (2010). Psychosocial outcomes of three triage methods for the management of borderline abnormal cervical smears: an open randomised trial. BMJ: British Medical Journal, 340, b4491-1-b4491-13. [More Information]
  • Bell, K., Irwig, L., Hayen, A., Macaskill, P., Craig, J. (2010). Should response rules be used to decide continued subsidy of very expensive drugs? A checklist for decision makers. Pharmacoepidemiology and drug safety, 19(1), 99-105. [More Information]
  • Craig, J., Williams, G., Jones, M., Codarini, M., Macaskill, P., Hayen, A., Irwig, L., Fitzgerald, D., Isaacs, D., McCaskill, M. (2010). The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses. BMJ: British Medical Journal, 340, c1594-1-c1594-12. [More Information]
  • Lucas, N., Macaskill, P., Irwig, L., Bogduk, N. (2010). The development of a quality appraisal tool for studies of diagnostic reliability (QAREL). Journal of Clinical Epidemiology, 63(8), 854-861. [More Information]
  • Bell, K., Hayen, A., Irwig, L., Macaskill, P., Craig, J., Ensrud, K., Bauer, D. (2010). The Value of Routine BMD Monitoring After Starting Bisphosphonate Treatment. Journal of Bone and Mineral Research, 25(1), 173-174. [More Information]
  • Adelstein, B., Irwig, L., Macaskill, P., Turner, R., Chan, S., Katelaris, P. (2010). Who needs colonoscopy to identify colorectal cancer? Bowel symptoms do not add substantially to age and other medical history. Alimentary Pharmacology and Therapeutics, 32(2), 270-281. [More Information]

2009

  • Craig, J., Simpson, J., Williams, G., Lowe, A., Reynolds, G., McTaggart, S., Hodson, E., Carapetis, J., Cranswick, N., Smith, G., Irwig, L., Caldwell, P., Roy, L., et al (2009). Antibiotic prophylaxis and recurrent urinary tract infection in children. New England Journal of Medicine, 361(18), 1748-1759. [More Information]
  • Irwig, L., Bossuyt, P., Glasziou, P., Gatsonis, C., Lijmer, J. (2009). Designing studies to ensure that estimates of test accuracy will travel. In J. Andre Knottnerus, Frank Buntinx (Eds.), The Evidence Base of Clinical Diagnosis: Theory and Methods of Diagnostic Research, (pp. 96-117). West Sussex, UK: Wiley-Blackwell Publishing.
  • Leeflang, M., Bossuyt, P., Irwig, L. (2009). Diagnostic test accuracy may vary with prevalence: implications for evidence-based diagnosis. Journal of Clinical Epidemiology, 62(1), 5-12. [More Information]
  • Davey, E., Irwig, L., Macaskill, P., Clarke, J., Thurloe, J., Hyne, S., Biro, C. (2009). Does providing previous results change the accuracy of cervical cytology? Acta Cytologica, 53(6), 644-652. [More Information]
  • Keenan, K., Hayen, A., Neal, B., Irwig, L. (2009). Long term monitoring in patients receiving treatment to lower blood pressure: analysis of data from placebo controlled randomised controlled trial. BMJ: British Medical Journal, 338, 1-7. [More Information]
  • Brennan, M., Houssami, N., Lord, S., Macaskill, P., Irwig, L., Dixon, J., Warren, R., Ciatto, S. (2009). Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management. Journal of Clinical Oncology, 27(33), 5640-5649. [More Information]
  • McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Klein, B., Wang, J., Mitchell, P., Vingerling, J., de Jong, P., et al (2009). Meta-analysis: retinal vessel caliber and risk for coronary heart disease. Annals of Internal Medicine, 151(6), 404-413. [More Information]
  • Bell, K., Hayen, A., Macaskill, P., Craig, J., Neal, B., Irwig, L. (2009). Mixed models showed no need for initial response monitoring after starting antihypertensive therapy. Journal of Clinical Epidemiology, 62, 650-659. [More Information]
  • McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Klein, B., Wang, J., Mitchell, P., Vingerling, J., de Jong, P., et al (2009). Prediction of incident stroke events based on retinal vessel caliber: a systematic review and individual-participant meta-analysis. American Journal of Epidemiology, 170(11), 1323-1332. [More Information]
  • Lucas, N., Macaskill, P., Irwig, L., Moran, R., Bogduk, N. (2009). Reliability of physical examination for diagnosis of myofascial trigger points: A systematic review of the literature. Clinical Journal of Pain, 25(1), 80-89. [More Information]
  • Lord, S., Irwig, L., Bossuyt, P. (2009). Using the principles of randomized controlled trial design to guide test evaluation. Medical Decision Making: an international journal, 29(5), E1-E12. [More Information]
  • Bell, K., Hayen, A., Macaskill, P., Irwig, L., Craig, J., Ensrud, K., Bauer, D. (2009). Value of routine monitoring of bone mineral density after starting bisphosphonate treatment: secondary analysis of trial data. BMJ: British Medical Journal, 338(b2266), b2266-1-b2266-5. [More Information]

2008

  • Adelstein, B., Irwig, L., Macaskill, P., Katelaris, P., Jones, D., Bokey, E. (2008). A self administered reliable questionnaire to assess lower bowel symptoms. BMC Gastroenterology, 8(8), 1-9. [More Information]
  • Houssami, N., Ciatto, S., Macaskill, P., Lord, S., Warren, R., Dixon, J., Irwig, L. (2008). Accuracy and Surgical Impact of Magnetic Resonance Imaging in Breast Cancer Staging: Systematic Review and Meta-Analysis in Detection of Multifocal and Multicentric Cancer. Journal of Clinical Oncology, 26(19), 3248-3258. [More Information]
  • McGeechan, K., Macaskill, P., Irwig, L., Liew, G., Wong, T. (2008). Assessing New Biomarkers and Predictive Models for Use in Clinical Practice. Archives of Internal Medicine, 168(21), 2304-2310. [More Information]
  • Irwig, L., Glasziou, P. (2008). Choosing the best monitoring tests. In P Glasziou, L Irwig and J K Aronson (Eds.), Evidence-based Medical Monitoring:From Principles to Practice, (pp. 63-74). Oxford: Blackwell Publishers.
  • Hewitson, P., Glasziou, P., Watson, E., Towler, B., Irwig, L. (2008). Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update. American Journal of Gastroenterology, 103(6), 1541-1549. [More Information]
  • Entwistle, V., Carter, S., Trevena, L., Flitcroft, K., Irwig, L., McCaffery, K., Salkeld, G. (2008). Communicating about screening. BMJ: British Medical Journal, 337(7673), 789-791. [More Information]
  • Glasziou, P., Irwig, L., Aronson, J. (2008). Evidence-based Medical Monitoring:From Principles to Practice. Oxford: Blackwell Publishers.
  • Craig, J., Webster, A., Mitchell, A., Irwig, L. (2008). Expanding the Evidence Base in Transplantation: More and Better Randomized Trials, and Extending the Value of Observational Data. Transplantation, 86(1), 32-35. [More Information]
  • McCaffery, K., Irwig, L., Chan, S., Macaskill, P., Barratt, A., Lewicka, M., Clarke, J., Weisberg, E. (2008). HPV testing versus repeat Pap testing for the management of a minor abnormal Pap smear: Evaluation of a decision aid to support informed choice. Patient Education and Counseling, 73(3), 473-481. [More Information]
  • Turner, M., van Schalkwyk, J., Irwig, L. (2008). Lax sphygmomanometer standard causes overdetection and underdetection of hypertension: a computer simulation study. Blood pressure monitoring, 13(2), 91-99. [More Information]
  • Glasziou, P., Irwig, L., Heritier, S., Simes, R., Tonkin, A. (2008). Monitoring cholesterol levels: Measurement error or true change? Annals of Internal Medicine, 148(9), 656-661. [More Information]
  • Glasziou, P., Irwig, L., Heritier, S. (2008). Monitoring cholesterol-modifying interventions. In P Glasziou, L Irwig and J K Aronson (Eds.), Evidence-based Medical Monitoring:From Principles to Practice, (pp. 245-253). Oxford: Blackwell Publishers.
  • Irwig, L., Healey, P., D'Assuncao, J., Macaskill, P. (2008). Monitoring intraocular pressure in glaucoma. In P Glasziou, L Irwig and J K Aronson (Eds.), Evidence-based Medical Monitoring:From Principles to Practice, (pp. 325-334). Oxford: Blackwell Publishers.
  • Bell, K., Craig, J., Irwig, L. (2008). Monitoring the initial response to treatment. In P Glasziou, L Irwig and J K Aronson (Eds.), Evidence-based Medical Monitoring:From Principles to Practice, (pp. 75-89). Oxford: Blackwell Publishers.
  • Barratt, A., Cumming, R., Irwig, L., Glasziou, P., Guyatt, G., Muir Gray, J., Hicks, N., Raffle, A. (2008). Moving from evidence to action: Recommendations about screening. In Gordon Guyatt & Drummond Rennie (Eds.), Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, (pp. 663-678). United States: American Medical Association.
  • Trevena, L., Irwig, L., Barratt, A. (2008). Randomized trial of a self-administered decision aid for colorectal cancer screening. Journal of Medical Screening, 15(2), 76-81. [More Information]
  • McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Sharrett, A., Klein, B., Wang, J., Chambless, L., Wong, T. (2008). Risk Prediction of Coronary Heart Disease Based on Retinal Vascular Caliber (from the Atherosclerosis Risk In Communities [ARIC] Study). The American Journal of Cardiology, 102(1), 58-63. [More Information]
  • Irwig, L., Irwig, J., Trevena, L., Sweet, M. (2008). Smart Health Choices: Making sense of health advice. United Kingdom: Hammersmith Press.
  • Leeflang, M., Deeks, J., Gastonis, C., Bossuyt, P., Irwig, L., Craig, J. (2008). Systematic reviews of diagnostic test accuracy. Annals of Internal Medicine, 149(12), 889-897.
  • Chan, S., Deeks, J., Macaskill, P., Irwig, L. (2008). Three methods to construct predictive models using logistic regression and likelihood ratios to facilitate adjustment for pretest probability give similar results. Journal of Clinical Epidemiology, 61(1), 52-63. [More Information]
  • Bell, K., Irwig, L., Craig, J., Macaskill, P. (2008). Use of randomised trials to decide when to monitor response to new treatment. BMJ: British Medical Journal, 336, 361-365. [More Information]
  • Glasziou, P., Irwig, L., Deeks, J. (2008). When should a new test become the current reference standard? Annals of Internal Medicine, 149(11), 816-821. [More Information]

2007

  • Lord, S., Irwig, L., Simes, R. (2007). A philosophical approach to diagnostic test evaluation - In Response. Annals of Internal Medicine, 146(10), 757-758.
  • Davey, E., D'Assuncao, J., Irwig, L., Macaskill, P., Chan, S., Richards, A., Farnsworth, A. (2007). Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study. BMJ: British Medical Journal, 335(7609), 31-39. [More Information]
  • Irwig, L., Macaskill, P., Chan, S., D'Assuncao, J., Richards, A., Farnsworth, A. (2007). Cervical cytology reading times: A comparison between thinprep imager and conventional methods. Diagnostic Cytopathology, 35(9), 550-4. [More Information]
  • Biesheuvel, C., Barratt, A., Howard, K., Houssami, N., Irwig, L. (2007). Effects of study methods and biases on estimates of invasive breast cancer overdetection with mammography screening: a systematic review. Lancet Oncology, 8(12), 1129-1138. [More Information]
  • Trevena, L., Irwig, L., Isaacs, A., Barratt, A. (2007). GPs want tailored, user friendly evidence summaries--a cross sectional study in New South Wales. Australian Family Physician, 36(12), 1065-1069. [More Information]
  • Howard, K., Salkeld, G., McCaffery, K., Irwig, L. (2007). HPV triage testing or repeat Pap smear for the management of atypical squamous cells (ASCUS) on Pap smear: is there evidence of process utility? Health Economics, Published Online: Sep 3 2007, 1-13. [More Information]
  • Biesheuval, C., Irwig, L., Bossuyt, P. (2007). Observed Differences in Diagnostic Test Accuracy between Patient Subgroups: Is It Real or Due to Reference Standard Misclassification? Clinical Chemistry (Washington, DC), 53(10), 1725-1729. [More Information]
  • McCaffery, K., Irwig, L., Bossuyt, P. (2007). Patient Decision Aids to Support Clinical Decision Making: Evaluating the Decision or the Outcomes of the Decision. Medical Decision Making: an international journal, 27(5), 619-625. [More Information]
  • Irwig, L., Irwig, J., Trevena, L., Sweet, M. (2007). Smart Health Choice Essentials. Evidence-Based Medicine, 12(6), 164-166.
  • Irwig, L., Trevena, L., Judy, I., Sweet, M. (2007). Smart Health Choices: Making sense of health advice. United Kingdom: Hammersmith Press.
  • Bossuyt, P., Reitsma, J., Bruns, D., Gatsonis, C., Glasziou, P., Irwig, L., Lijmer, J., Moher, D., Rennie, D., de Vet, H. (2007). Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Veterinary Clinical Pathology, 36(1), 8-12.

2006

  • Bossuyt, P., Irwig, L., Craig, J., Glasziou, P. (2006). Comparative accuracy: assessing new tests against existing diagnostic pathways. British Medical Journal, 332(7549), 1089-92. [More Information]
  • Bossuyt, P., Irwig, L., Craig, J., Glasziou, P. (2006). Diagnosis - Comparative accuracy: assessing new tests against existing diagnostic pathways. BMJ: British Medical Journal, 332(7549), 1089-1092.
  • Davey, E., Barratt, A., Irwig, L., Chan, S., Macaskill, P., Mannes, P., Saville, A. (2006). Effect of study design and quality on unsatisfactory rates, cytology classifications, and accuracy in liquid-based versus conventional cervical cytology: a systematic review. The Lancet, 367(9505), 122-132. [More Information]
  • Irwig, L., Houssami, N., Armstrong, B., Glasziou, P. (2006). Evaluating new screening tests for breast cancer. BMJ: British Medical Journal, 332(7543), 678-679. [More Information]
  • Trevena, L., Irwig, L., Barratt, A. (2006). Impact of privacy legislation on the number and characteristics of people who are recruited for research: a randomised controlled trial. Journal of Medical Ethics, 32(8), 473-477. [More Information]
  • Irwig, L., McCaffery, K., Salkeld, G., Bossuyt, P. (2006). Informed choice for screening: implications for evaluation. BMJ: British Medical Journal, 332(7550), 1148-1150. [More Information]
  • Jabbour, J., Irwig, L., Macaskill, P., Hennessy, M. (2006). Intraocular lens power in bilateral cataract surgery: Whether adjusting for error of predicted refraction in the first eye improves prediction in the second eye. Journal of Cataract and Refractive Surgery, 32(12), 2091-2097. [More Information]
  • Irwig, L. (2006). Is evidence overrated? An international symposium on the nature, purposes, ethics and politics of evidence in a democracy: Keynote Address. Academy of Science of South Africa (ASSAF) 2006, Pretoria, South Africa: Academy of Science of South Africa.
  • Turner, M., Irwig, L., Bune, A., Kam, P., Baker, A. (2006). Lack of sphygmomanometer calibration causes over- and under-detection of hypertension: a computer simulation study. Journal of Hypertension, 24(10), 1931-1938. [More Information]
  • Irwig, L., Macaskill, P., Walter, S., Houssami, N. (2006). New methods give better estimates of changes in diagnostic accuracy when prior information is provided. Journal of Clinical Epidemiology, 59(3), 299-307. [More Information]
  • Houssami, N., Irwig, L., Ciatto, S. (2006). Radiological surveillance of interval breast cancers in screening programmes. Lancet Oncology, 7(3), 259-265. [More Information]
  • Chan, S., Macaskill, P., Irwig, L., Walter, S. (2006). Re: In response to the correspondence arising from Twisk and Proper: evaluation of the results of a randomized controlled trial: how to define changes between baseline and follow-up. Journal of Clinical Epidemiology, 59(3), 323-323.
  • Lord, S., Irwig, L., Simes, R. (2006). When is measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized trials? Annals of Internal Medicine, 144(11), 850-855. [More Information]

2005

  • Trevena, L., Barratt, A., Irwig, L. (2005). Applying population level evidence with individual patients: An HRT decision aid example. 3rd International Conference of Evidence-Based Healthcare Teachers and Developers. BMJ Publications.
  • McCaffery, K., Irwig, L. (2005). Australian women's needs and preferences for information about human papillomavirus in cervical screening. Journal of Medical Screening, 12(3), 134-41. [More Information]
  • Houssami, N., Ciatto, S., Ambrogetti, D., Catarzi, S., Risso, G., Bonardi, R., Irwig, L. (2005). Florence-Sydney Breast Biopsy Study: sensitivity of ultrasound-guided versus freehand fine needle biopsy of palpable breast cancer. Breast Cancer Research and Treatment, 89(1), 55-59. [More Information]
  • Howard, K., Salkeld, G., Irwig, L., Adelstein, B. (2005). High participation rates are not necessary for cost-effective colorectal cancer screening. Journal of Medical Screening, 12(2), 96-102. [More Information]
  • Turner, M., Irwig, L., Bune, A., Baker, A., Kam, P. (2005). Lack of sphygmomanometer calibration causes over- and under-detection of hypertension. 6th Biennial Conference of The Metrology Society of Australia.
  • Macaskill, P., Glasziou, P., Irwig, L. (2005). Meta-analysis of Diagnostic Tests. In Peter Armitage and Theodore Colton (Eds.), Encyclopedia of Biostatistics – 2nd Edition, (pp. 3213-3221). John Wiley & Sons.
  • Tew, K., Irwig, L., Matthews, A., Crowe, P., Macaskill, P. (2005). Meta-analysis of sentinel node imprint cytology in breast cancer. British Journal of Surgery, 92(9), 1068-1080. [More Information]
  • Barratt, A., Howard, K., Irwig, L., Houssami, N. (2005). Model of outcomes of screening mammography - Authors' reply. British Medical Journal, 331(7512), 351-351.
  • Barratt, A., Howard, K., Irwig, L., Salkeld, G., Houssami, N. (2005). Model of outcomes of screening mammography: Author’s reply. BMJ: British Medical Journal, 331(7512), 351.
  • Barratt, A., Howard, K., Irwig, L., Salkeld, G., Houssami, N. (2005). Model of outcomes of screening mammography: information to support informed choices. BMJ: British Medical Journal, 330(7497), 936-940. [More Information]
  • Glasziou, P., Irwig, L., Mant, D. (2005). Monitoring in chronic disease: A rational approach. British Medical Journal, 330, 644-648.
  • Houssami, N., Irwig, L., Ung, O. (2005). Review of complex breast cysts: Implications for cancer detection and clinical practice. ANZ Journal of Surgery, 75(12), 1080-1085.
  • Trevena, L., Irwig, L., Barratt, A. (2005). The impact of privacy legislation on the characteristics of people who are recruited for research: a randomised controlled trial. NHMRC Ethics in Human Research Conference, Australia: NHMRC: National Health and Medical ResearchCouncil.
  • Houssami, N., Irwig, L., Simpson, J., McKessar, M., Blome, S., Noakes, J. (2005). The Influence of Knowledge of Mammography Findings on the Accuracy of Breast Ultrasound in Symptomatic Women. The Breast Journal, 11(3), 167-172. [More Information]
  • Deeks, J., Macaskill, P., Irwig, L. (2005). The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. Journal of Clinical Epidemiology, 58(9), 882-893. [More Information]

2004

  • Trevena, L., Irwig, L., Barratt, A. (2004). A general practice-based randomised trial of a decision aid for colorectal cancer screening. 2nd Conference for the European Association of Communication in Healthcare. (IEEE) Institute of Electrical and Electronics Engineers.
  • Irwig, L., Macaskill, P., Farnsworth, A., Wright, R., McCool, J., Barratt, A., Simpson, J. (2004). A randomized crossover trial of PAPNET for primary cervical screening. Journal of Clinical Epidemiology, 57(1), 75-81.
  • Loy, C., Irwig, L. (2004). Accuracy Of Diagnostic Tests Read With And Without Clinical Information: A Systematic Review. JAMA: The Journal of the American Medical Association, 292(13), 1602-1609. [More Information]
  • Chan, S., Macaskill, P., Irwig, L., Walter, S. (2004). Adjustment For Baseline Measurement Error In Randomized Controlled Trials Induces Bias. Contemporary Clinical Trials, 25(4), 408-416. [More Information]
  • Bakis, S., Irwig, L., Wood, G., Wong, D. (2004). Exfoliative Cytology As A Diagnostic Test For Basal Cell Carcinoma: A Meta-Analysis. British Journal of Dermatology, 150(8), 829-836.
  • Irwig, L., Houssami, N., Van Vliet, C. (2004). New Technologies In Screening For Breast Cancer: A Systematic Review Of Their Accuracy. British Journal of Cancer, 90(11), 2118-2122.
  • Codarini, M., Williams, G., Chan, S., Craig, J., Irwig, L., Macaskill, P., McCaskill, M. (2004). Outcomes for children with fever presenting to a Paediatric Emergency Department. Royal Australasian College of Physicians Annual Scientific Meeting. British Medical Journal Publishing Group.
  • Irwig, L., Houssami, N., Simpson, J., McKessar, M., Blome, S., Noakes, J. (2004). The Influence Of Clinical Information On The Accuracy Of Diagnostic Mammography. Breast Cancer Research and Treatment, 85(3), 223-238.
  • Marschner, C., Emberson, J., Irwig, L., Walter, S. (2004). The Number Needed To Treat (Nnt) Can Be Adjusted For Bias When The Outcome Is Measured With Error. Journal of Clinical Epidemiology, 57(12), 1244-1242. [More Information]

2003

  • Chen, J., Conigrave, K., Macaskill, P., Whitfield, J., Irwig, L. (2003). Combining carbohydrate-deficient transferrin and gamma-glutamyltransferase to increase diagnostic accuracy for problem drinking. Alcohol and Alcoholism, 38(6), 574-582.
  • Campbell, D., de Campo, M., Elwood, M., Fong, K., Irwig, L., Manser, R., Peters, M., Pederson, K., St John, J. (2003). Lung Cancer Screening By Helical Computed Tomography. VIC: National Cancer Control Initiative.
  • Trevena, L., Barratt, A., McCaffery, K., Irwig, L. (2003). More haste less speed in the implementation of screening decision aids. BMJ Rapid Response.
  • Trevena, L., Barratt, A., Irwig, L. (2003). New approaches to preference elicitation, estimation and representation of probabilistic screening information within a home-based decision aid for colorectal cancer screening in general practice. 2nd International Shared Decision Making Conference.
  • Askie, L., Henderson-Smart, D., Irwig, L., Simpson, J. (2003). Oxygen-saturation targets and outcomes in extremely preterm infants. New England Journal of Medicine, 349, 959-967.
  • Houssami, N., Irwig, L., Simpson, J., McKessar, M., Blome, S., Noakes, J. (2003). Sydney breast imaging accuracy study: comparative sensitivity and specificity of mammography and sonography in young women with symptoms. American Journal Of Roentgenology, 180(4), 935-940.
  • Houssami, N., Irwig, L., Simpson, J., McKessar, M., Blome, S., Noakes, J. (2003). The contribution of work-up or additional views to the accuracy of diagnostic mammography. The Breast, 12(4), 270-275.
  • Bossuyt, P., Reitsma, J., Bruns, D., Gatsonis, C., Glasziou, P., Irwig, L., Moher, D., Rennie, D., de Vet, H., Lijmer, J. (2003). The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clinical Chemistry (Washington, DC), 49(1), 7-18.
  • Bossuyt, P., Reitsma, J., Bruns, D., Gatsonis, C., Glasziou, P., Irwig, L., Lijmer, J., Moher, D., Rennie, D., de Vet, H. (2003). Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Clinical Chemistry (Washington, DC), 49(1), 1-6.

2002

  • Craig, J., Howman-Giles, R., Irwig, L., Wheeler, D., Williams, G. (2002). A critical appraisal of the evaluation of children with urinary tract infection (UTI) by diagnostic imaging.
  • Houssami, N., Irwig, L., Loy, C. (2002). Accuracy of combined breast imaging in young women. The Breast, 11(1), 36-40.
  • Berry, G., Smith, C., Macaskill, P., Irwig, L. (2002). Analytic methods for comparing two dichotomous screening or diagnostic tests applied to two populations of differing disease prevalence when individuals negative on both tests are unverified. Statistics in Medicine, 21(6), 853-862. [More Information]
  • Macaskill, P., Walter, S., Irwig, L., Franco, E. (2002). Assessing the gain in diagnostic performance when combining two diagnostic tests. Statistics in Medicine, 21(17), 2527-2546. [More Information]
  • Barratt, A., Irwig, L., Glasziou, P., Salkeld, G., Houssami, N. (2002). Benefits, harms and costs of screening mammography in women 70 years and over: a systematic review. Medical Journal of Australia, 176(6), 266-271.
  • Barratt, A., Mannes, P., Irwig, L., Trevena, L., Craig, J., Rychetnik, L. (2002). Cancer screening. Journal of Epidemiology and Community Health, 56(12), 899-902.
  • Barratt, A., Mannes, P., Irwig, L., Trevena, L., Craig, J., Rychetnik, L. (2002). Cancer Screening. Journal of Epidemiology and Community Health, 56(12), 899-902. [More Information]
  • Irwig, L., Bossuyt, P., Glasziou, P., Gatsonis,, C., Lijmer,, J. (2002). Designing studies to ensure that estimates of test accuracy are transferable. BMJ: British Medical Journal, , 669-671.
  • Irwig, L., Macaskill, P., Houssami, N. (2002). Evidence relevant to the investigation of breast symptoms: the triple test. The Breast, 11(3), 215-220.
  • Craig, J., Barratt, A., Cumming, R., Irwig, L., Salkeld, G. (2002). Feasibility study of the early detection and treatment of renal disease by mass screening. Internal Medicine Journal, 32(1-2), 6-14.
  • Barratt, A., Irwig, L., Cumming, R., Glasziou, P., Raffle, A., Hicks,, N., Muir, G. (2002). Moving from evidence to action: recommendations about screening. In Gordon Guyatt & Drummond Rennie (Eds.), Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, (pp. 583-597). United States: American Medical Association.
  • Poynten, I., Hanlon, M., Irwig, L., Gilbert, G. (2002). Serological diagnosis of pertussis: evaluation of IgA against whole cell and specific Bordetella pertussis antigens as markers of recent infection. Epidemiology and Infection, 128(2), 161-167.
  • Trevena, L., Irwig, L., Barratt, A. (2002). The art and science of clinical decision making in general practice: the development of a decision aid for colorectal cancer screening decisions. GP & PHC Research Conference, 2002, Adelaide: Primary Health Care Research and Information Service.
  • Houssami, N., Ciatto, S., Irwig, L., Simpson, J., Macaskill, P. (2002). The comparative sensitivity of mammography and ultrasound in women with breast symptoms: an age specific analysis. The Breast, 11(2), 125-130.

2001

  • Macaskill, P., Irwig, L., Walter Stephen, D. (2001). A comparison of methods to detect publication bias in meta-analysis. Statistics in Medicine, 20, 641-654.
  • Craig, J., Irwig, L., Stockler, M., Barratt, A., Cumming, R., Caplehorn, J. (2001). Clinical epidemiology education: to help culture change now and generate new research later. 4th International Conference on the Scientific Basis of Health Services.
  • Irwig, L., Walter Stephen, D. (2001). Estimating the number needed to treat (NNT) index when the data are subject to error. Statistics in Medicine, 20, 893-906.
  • Craig, J., Irwig, L., Stockler, M. (2001). Evidence-based medicine: useful tools for decision making. Medical Journal of Australia, 174, 248-253.
  • Barratt, A., Irwig, L., Glasziou, P., Cumming, R., Raffle, A., Hicks,, N., Gray, J., Guyatt,, G. (2001). Screening. In Pencheon D, Guest C, Melzer D, Muir-Gray (Eds.), Oxford Handbook of Public Health Practice, (pp. 236-243). United Kingdom: Oxford University Press.
  • Irwig, L., Glasziou, P., Bain,, C., Colditz, G. (2001). Systematic Reviews in Health Care: A Practical Guide. Australia: Cambridge University Press.
  • Williams, G., Craig, J., Irwig, L. (2001). Test performance of urinalysis and urine microscopy for the diagnosis of urinary tract infection in children: a meta-analysis. Westmead Association, Not Published: Not Published.

2000

  • Craig, J., Irwig, L., Knight, J., Roy, L. (2000). Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease due to reflux nephropathy? Pediatrics, 105(6), 1236-1241. [More Information]
  • Craig, J., Wheeler, D., Irwig, L., Howman-Giles, R. (2000). How accurate is dimercaptosuccinic acid (DMSA) scintigraphy for the diagnosis of acute pyelonephritis? A meta-analysis of experimental studies. The Journal of Nuclear Medicine, 41(6), 986-993.
  • Craig, J., Irwig, L., Ford, M., Willis, N., Howman-Giles, R., Uren, R., Rossleigh, M., Grunewald, S. (2000). Reliability of DMSA for the diagnosis of renal parenchymal abnormality in children. European Journal of Nuclear Medicine and Molecular Imaging, 27(11), 1610-1616. [More Information]
  • Scouller, K., Conigrave, K., Macaskill, P., Irwig, L., Whitfield, J. (2000). Should we use carbohydrate-deficient transferrin instead of gamma-glutamyltransferase for detecting problem drinkers? A systematic review and metaanalysis. Clinical Chemistry (Washington, DC), 46, 1894-1902.

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