Associate Professor Linda Bendall

Principal Research Fellow
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 9069
Fax +61 2 9845 9102

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Research interests

The Leukemia Cell Biology Group is focused on the impact of non-hematopoietic cells in the bone marrow on the behaviour of normal blood forming and leukaemia cells. For more detail go to http://www.wmi.usyd.edu.au/ourpeople/profiles/bendall_linda.htm

Selected grants

2013

  • Microenvironmentally Induced Acute Lymphoblastic Leukemia Cell Quiescence and Chemotherapy Evasion; Bendall L, Purton L, Stutton R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Improving Treatment for Acute Lymphoblastic Leukemia; Bendall L; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • Microenvironmental Impact in the Treatment of Acute Lymphoblastic Leukemia; Bendall L; Cancer Institute New South Wales/Career Development Fellowship.
  • Sphingosine Kinases as Potential Therapeutic Targets for Acute Lymphoblastic Leukemia; Bendall L; Cancer Council New South Wales/Research Project Grants.
  • Adiponectin and cholesterol a driving force in NASH immunopathogenesis; George J, Hebbard L, Bendall L; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Microenvironmentally induced ALL cell quiescence; Bendall L; Westmead Charitable Trust/Bridging Grant.
  • The role of the microenvironment in the treatment of leukemia; Bendall L; DVC Research/Bridging Support Fellowship.

2011

  • Sphingosine-1-phosphate receptor agonists as adjunct mobilizing agents - Improving Hematopoietic Stem Cell Mobilization; Bendall L, Bradstock K; Anthony Rothe Foundation/Research Support.
  • Reasons for mTOR treatment failure; Bendall L; DVC Research/Bridging Support Grant.
  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • MTA Incoming - Linda Bendall leukemia research: BEZ235, BMK120, BGT266 (Materials) from Novartis BLOCS # 12120; Yip S, Bendall L, Bennett S, Bennett S, Maton K; Novartis Pharmaceuticals Australia Pty Limited/Research Support.
  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The role of sphingosine-1-phosphate in haematopoietic stem cell egress from the bone marrow; Bendall L, Juarez J; Cancer Council New South Wales/Research Project Grants.
  • The BD Influx High Speed Cell Sorter; Kefford R, Cunningham A, Bendall L, Clarke C, Harris D, Alexander S, Tam P, Sorrell T, Iredell J, Bryan T, Rizos H, Wang Y, Hebbard L; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • CXCR4 in ALL cell trafficking and chemo-sensitivity; Bendall L; Anthony Rothe Foundation/Research Support.
  • Acute lymphoblastic leukaemia and the bone marrow microenvironment; Bendall L; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • Enhancement of the effects of cytotoxic agents by mTOR inhibitors in acute lymphoblastic leukemia; Bendall L, Bradstock K; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Antagonists of p38 MAPK as therapeutics for acute lymphoblastic leukemia.; Bendall L, Bradstock K; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Premiers Award for Outstanding Cancer Research Fellow 2008; Bendall L; Cancer Institute New South Wales/NSW Premier's Awards for Outstanding Cancer Research.

2007

  • Enhancement of the effects of cytotoxic agents by mTOR inhibitors in acute lymphoblastic leukemia; Bradstock K, Bendall L; Leukemia and Lymphoma Society (USA)/Research Grant.
  • Flow Cytometry support; Alexander S, Braithwaite A, Bradstock K, Bendall L, Gunning P, Henderson B, Kefford R, Reddel R, Rizos H, Jones C, Byrne J; Cancer Institute New South Wales/Infrastructure Grant.
  • Confocal microscope for cancer research in the northern hub; Robinson P, Gunning P, Hardeman E, Henderson B, Bendall L, Chircop (nee Fabbro) M; Cancer Institute New South Wales/Research Grant.
  • RES: Contract Research for Metastatix; Bendall L; Metastatix Inc (USA)/Grant-in-Aid.

2006

  • Regulation of beta-catenin localisation and its role in tumour cell migration; Henderson B, Bendall L; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • CXCR4 antagonists in acute lymphoblastic leukemias in NOD/SCID mice; Bendall L, Bradstock K; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms underlying synergy between SDF-1 and IL-7 in All; Bendall L; Anthony Rothe Foundation/Research Grants.
  • Cancer Inst NSW Fell05-Bendall; Bendall L; Cancer Institute New South Wales/Research Grant.

2003

  • Investigating the role of TNF alpha-family cytokines in lymphoma and leukaemia; Sedger L, Bendall L; Leukaemia Foundation of NSW/Research Grant.
  • Mechanisms by which CD44 variant exon 6 promotes disease progression in acute leukemia; Bendall L; Cure Cancer Australia Foundation/Research Support.
  • CD44v6 ligands involved in increased aggressiveness of acute lymphoblastic leukaemia; Bendall L; Leukaemia Foundation of NSW/Research Grant.
  • Inhibitors of the chemokine SDF-1 as new therapeutic agents for acute lymphoblastic leukemia; Bendall L; AnorMED/Research Support.

2002

  • Analysis of the effect of CD44 variant exon 6 expression on adhesion and migration of human leukaemic cells; Bendall L, Gottlieb D; DVC Research/Cancer Research Fund.
  • Inhibitors of the chemokine SDF-1 as new therapeutic agents for acute lymphoblastic leukemia; Bendall L; Anthony Rothe Foundation/Research Grant.
  • The role of SDF-1 in normal and leukemic pre-B cell interaction with bone marrow stroma; Bendall L; Anthony Rothe Foundation/Research Grant.
  • Class II bio hazard hood; Bendall L; Leukaemia Foundation of Australia/Research Grant.

2001

  • Analysis of the effect of CD44 variant exon 6 expression on adhesion and migration of human leukemic cells; Bendall L, Bradstock K, Gottlieb D; Leo and Jenny Leukaemia and Cancer Foundation/Leukaemia and Cancer Foundation.

1999

  • Effect of breast cancer cell co-culture with bone marrow stroma on myeloid metalloprotease production; Bendall L; DVC Research/Cancer Research Fund.

1997

  • Role of CD44 in the interaction between haemopoietic progenitors and bone marrow stroma; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Harun, N., Bradstock, K., Bendall, L. (2012). Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors. In Stefan Fruehauf, W. Jens Zeller and Gary Calandra (Eds.), Novel Developments in Stem Cell Mobilization, (pp. 37-54). New York: Springer Science + Business Media.
  • Shaw, S., Haylock, D., Lock, R., Bendall, L., Simmons, P., Johnston, H., Fletcher, K., Webb, R., Brown, T., Liem, N., et al (2005). The role of hyaluronic acid in normal and perturbed hemopoietic stem cell biology. In E.A. Balazs and V.C. Hascall (Eds.), Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications, (pp. 293-299). New Jersey: Matrix Biology Inst.

Journals

  • Bendall, L., Green, D. (2014). Autopsy of a cell. Leukemia, 28(6), 1341-1343. [More Information]
  • Wallington-Beddoe, C., Powell, J., Tong, D., Pitson, S., Bradstock, K., Bendall, L. (2014). Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression. Cancer Research, 74(10), 2803-2815. [More Information]
  • Winkler, I., Bendall, L., Forristal, C., Helwani, F., Nowlan, B., Barbier, V., Shen, Y., Cisterne, A., Sedger, L., Levesque, J. (2013). B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2. Haematologica: the hematology journal, 98(3), 325-333. [More Information]
  • Wallington-Beddoe, C., Bradstock, K., Bendall, L. (2013). Oncogenic properties of sphingosine kinases in haematological malignancies. British Journal of Haematology, 161(5), 623-638. [More Information]
  • Welschinger, R., Liedtke, F., Basnett, J., Dela Pena, A., Juarez, J., Bradstock, K., Bendall, L. (2013). Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice. Experimental Hematology, 41(3), 293-302.e1. [More Information]
  • Saunders, P., Weiss, J., Welschinger, R., Baraz, R., Bradstock, K., Bendall, L. (2013). RAD001 (everolimus) induces dose-dependent changes to cell cycle regulation and modifies the cell cycle response to vincristine. Oncogene, 32(40), 4789-4797. [More Information]
  • Bendall, L., Basnett, J. (2013). Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. Current Opinion In Hematology, 20(4), 281-288. [More Information]
  • Wallington-Beddoe, C., Don, A., Hewson, J., Qiao, Q., Papa, R., Lock, R., Bradstock, K., Bendall, L. (2012). Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia. PLoS One, 7(5), 1-7. [More Information]
  • Klionsky, D., Abdalla, F., Abeliovich, H., Abraham, R., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J., Bendall, L., Feng, C., Sidhu, S., Xia, P., et al (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445-544. [More Information]
  • Winkler, I., Pettit, A., Raggatt, L., Jacobsen, R., Forristal, C., Barbier, V., Nowlan, B., Cisterne, A., Bendall, L., Sims, N., et al (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia, 26(7), 1594-1601. [More Information]
  • Khan, N., Cisterne, A., Baraz, R., Bradstock, K., Bendall, L. (2012). Para-NO-aspirin inhibits NF-kB and induces apoptosis in B-cell progenitor acute lymphoblastic leukemia. Experimental Hematology, 40(3), 207-215.e1. [More Information]
  • Juarez, J., Harun, N., Thien, M., Welschinger, R., Baraz, R., Dela Pena, A., Pitson, S., Rettig, M., DiPersio, J., Bradstock, K., Bendall, L. (2012). Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood, 119(3), 707-716. [More Information]
  • Wallington-Beddoe, C., Hewson, J., Bradstock, K., Bendall, L. (2011). FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy, 7(7), 707-715. [More Information]
  • Bendall, L. (2011). It's all in the timing. Blood, 118(23), 5983-5984. [More Information]
  • To, L., Levesque, J., Herbert, K., Winkler, I., Bendall, L., Hiwase, D., Antonenas, V., Rice, A., Gottlieb, D., Mills, A., Rasko, J., et al (2011). Mobilisation strategies for normal and malignant cells. Pathology, 43(6), 547-565. [More Information]
  • Saunders, P., Cisterne, A., Weiss, J., Bradstock, K., Bendall, L. (2011). The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia. Haematologica: the hematology journal, 96(1), 69-77. [More Information]
  • Wei, J., Yee, C., Ramanathan, P., Bendall, L., Williamson, P. (2011). Variation in Immunophenotype of Lactating Mice. American Journal of Reproductive Immunology, 89, 178-184. [More Information]
  • Sedger, L., Katewa, A., Petterson, A., Osvath, S., Farrell, G., Stewart, G., Bendall, L., Alexander, S. (2010). Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL- and TRAIL-double deficient mice. Blood, 115(16), 3258-3268. [More Information]
  • Bendall, L. (2010). New and Emerging Drug Targets for the Treatment of Hematological Malignancies. Current Drug Targets, 11(7), 767-8. [More Information]
  • Deo, S., Bendall, L. (2010). The Potential and Limitations of p38MAPK as a Drug Target for the Treatment of Hematological Malignancies. Current Drug Targets, 11(7), 823-833. [More Information]
  • Juarez, J., Thien, M., Dela Pena, A., Baraz, R., Bradstock, K., Bendall, L. (2009). CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK. British Journal of Haematology, 145, 491-499. [More Information]
  • Crazzolara, R., Bendall, L. (2009). Emerging treatments in acute lymphoblastic leukemia. Current Cancer Drug Targets, 9(1), 19-31. [More Information]
  • Deo, S., Bradstock, K., Bendall, L. (2009). p38MAPK inhibitors attenuate cytokine production by bone marrow stromal cells and reduce stroma-mediated proliferation of acute lymphoblastic leukemia cells. Cell Cycle, 8(18), 2977-2985. [More Information]
  • Crazzolara, R., Cisterne, A., Thien, M., Hewson, J., Baraz, R., Bradstock, K., Bendall, L. (2009). Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. Blood, 113(14), 3297-3306. [More Information]
  • Crazzolara, R., Bradstock, K., Bendall, L. (2009). RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia. Autophagy, 5(5), 727-728. [More Information]
  • Johnson, M., Sharma, M., Jamieson, C., Henderson, J., Mok, M., Bendall, L., Henderson, B. (2009). Regulation of beta-catenin trafficking to the membrane in living cells. Cellular Signalling, 21(2), 339-348. [More Information]
  • Khan, N., Cisterne, A., Devidas, M., Shuster, J., Hunger, S., Shaw, P., Bradstock, K., Bendall, L. (2008). Expression of CD44, but not CD44v6, predicts relapse in children with B cell progenitor acute lymphoblastic leukemia lacking adverse or favorable genetics. Leukemia and lymphoma, 49(4), 710-718. [More Information]
  • Khan, N., Bradstock, K., Bendall, L. (2007). Activation of Wnt/beta-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia. British Journal of Haematology, 138(3), 338-348. [More Information]
  • Juarez, J., Dela Pena, A., Baraz, R., Hewson, J., Khoo, M., Cisterne, A., Fricker, S., Fujii, N., Bradstock, K., Bendall, L. (2007). CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment. Leukemia, 21(6), 1249-1257. [More Information]
  • Juarez, J., Baraz, R., Deo, S., Bradstock, K., Bendall, L. (2007). Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia. Haematologica: the hematology journal, 92(4), 450-459. [More Information]
  • Belov, L., Mulligan, S., Barber, N., Woolfson, A., Scott, M., Stoner, K., Chrisp, J., Sewell, W., Bradstock, K., Bendall, L., Sartor, M., Young, G., Wiley, J., Christopherson, R., et al (2006). Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray. British Journal of Haematology, 135(2), 184-97. [More Information]
  • Christopherson, R., Stoner, K., Barber, N., Belov, L., Woolfson, A., Scott, M., Bendall, L., Mulligan, S. (2006). Classification of AML using a monoclonal antibody microarray. Methods in molecular medicine, 125, 241-251. [More Information]
  • Khan, N., Bendall, L. (2006). Role of WNT signaling in normal and malignant hematopoiesis. Histology and Histopathology: cellular and molecular biology, 21(7), 761-774. [More Information]
  • Bendall, L. (2005). Chemokines and their receptors in disease. Histology and Histopathology: cellular and molecular biology, 20(3), 907-926. [More Information]
  • Bendall, L., Baraz, R., Juarez, J., Shen, W., Bradstock, K. (2005). Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia. Cancer Research. [More Information]
  • Campana, D., Iwamoto, D., Bendall, L., Bradstock, K. (2005). Growth requirements and immunophenotype of acute lymphoblastic leukemia progenitors. Blood, 105(10), 4150. [More Information]
  • Sloane, A., Raso, V., Dimitrov, D., Xiao, X., Deo, S., Muljadi, N., Restuccia, D., Turville, S., Kearney, C., Broder, C., Zoellner, H., Cunningham, A., Bendall, L., Lynch, G. (2005). Marked structural and functional heterogeneity in CXCR4: Separation of HIV-1 and SDF-1 alpha responses. Immunology and Cell Biology, 83(2), 129-143. [More Information]
  • Bendall, L., Bradstock, K. (2005). New therapies targeting chemokine receptors: Can changing the way cells traffic be used to treat human disease? Current Topics in Membranes, 55, 331-365.
  • Nilsson, S., Johnston, H., Whitty, G., Williams, B., Webb, R., Denhardt, D., Bertoncello, I., Bendall, L., Simmons, P., Haylock, D. (2005). Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood, 106(4), 1232-1239. [More Information]
  • Juarez, J., Bendall, L., Bradstock, K. (2004). Chemokines And Their Receptors As Therapeutic Targets: The Role Of The Sdf-1/Cxcr4 Axis. Current Pharmaceutical Design, 10(11), 1245-1259.
  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts. Breast Cancer Research and Treatment, 83(3), 211-220.
  • Bendall, L., Nilsson, S., Khan, N., James, A., Bonnet, C., Lock, R., Papa, R., Bradstock, K., Gottlieb, D. (2004). Role of CD44 variant exon 6 in acute lymphoblastic leukaemia: association with altered bone marrow localisation and increased tumor burden. Leukemia, 18(7), 1308-1311.
  • Juarez, J., Bendall, L. (2004). SDF-1 And CXCR4 In Normal And Malignant Hematopoiesis. Histology and Histopathology: cellular and molecular biology, 19(1), 299-309.
  • Bendall, L., James, A., Zannettino, A., Simmons, P., Gottlieb, D., Bradstock, K. (2003). A novel CD44 antibody identifies an epitope that is aberrantly expressed on acute lymphoblastic leukaemia cells. Immunology and Cell Biology, 81(4), 311-319.
  • Lévesque, J., Hendy, J., Takamatsu, Y., Simmons, P., Bendall, L. (2003). Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. Journal of Clinical Investigation, 111(2), 187-196.
  • Juarez, J., Gottlieb, D., Bradstock, K., Bendall, L. (2003). Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia, 17(7), 1294-1300.
  • Zannettino, A., Roubelakis, M., Welldon, K., Jackson, D., Simmons, P., Bendall, L., Henniker, A., Harrison, K., Niutta, S., Bradstock, K., et al (2003). Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration. Biochemical Journal, 370(2), 537-549.
  • Saad, S., Gottlieb, D., Bradstock, K., Overall, C., Bendall, L. (2002). Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts. Cancer Research, 62, 283-289.
  • McQibban,, G., Butler,, G., Gong,, J., Bendall, L., Power, C., Clark-Lewis, I., Overall, M. (2001). Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. Journal of Biological Chemistry, 276(47), 43503-43508.
  • Shen, W., Bendall, L., Gottlieb, D., Bradstock, K. (2001). The chemokine receptor CXCR4 enhances integrin mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow. Experimental Hematology, 29(12), 1439-1447.
  • Bendall, L., Bradstock, K., Gottlieb, D. (2000). Expression of CD44 variant exons in acute myeloid leukemia is more common and more complex than that observed in normal blood, bone marrow or CD34+ cells. Leukemia, 14(7), 1239-1246.
  • Gu, B., Zhang, W., Bendall, L., Chessell, I., Buell, G., Wiley, J. (2000). Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors. American Journal of Physiology: Cell Physiology, 279(4), C1189-C1197.
  • Saad, S., Bendall, L., James, A., Gottlieb, D., Bradstock, K. (2000). Induction of matrix metalloproteinases MMP-1 and MMP-2 by co-culture of breast cancer cells and bone marrow fibroblasts. Breast Cancer Research and Treatment, 63(2), 105-115.

Conferences

  • Sedger, L., Bendall, L., Gottlieb, D., Alexander, S., Osvath, S. (2005). A novel mechanism of viral subversion of TNF-R signalling by the poxvirus TNF-R like protein, T2. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Juarez, J., Hewson, J., Cisterne, A., Baraz, R., Bradstock, K., Bendall, L. (2005). CXCR4 antagonists mobilize acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment in mice. 47th Annual Meeting of the American Society of Hematology (ASH), United States: American Society of Hematology.
  • Khan, N., Bradstock, K., Bendall, L. (2005). The Wnt/beta-catenin pathway promotes growth and survival of acute lymphoblastic leukaemia (ALL) cells in vitro. 47th Annual Meeting of the American Society of Hematology (ASH), United States: American Society of Hematology.

2014

  • Bendall, L., Green, D. (2014). Autopsy of a cell. Leukemia, 28(6), 1341-1343. [More Information]
  • Wallington-Beddoe, C., Powell, J., Tong, D., Pitson, S., Bradstock, K., Bendall, L. (2014). Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression. Cancer Research, 74(10), 2803-2815. [More Information]

2013

  • Winkler, I., Bendall, L., Forristal, C., Helwani, F., Nowlan, B., Barbier, V., Shen, Y., Cisterne, A., Sedger, L., Levesque, J. (2013). B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2. Haematologica: the hematology journal, 98(3), 325-333. [More Information]
  • Wallington-Beddoe, C., Bradstock, K., Bendall, L. (2013). Oncogenic properties of sphingosine kinases in haematological malignancies. British Journal of Haematology, 161(5), 623-638. [More Information]
  • Welschinger, R., Liedtke, F., Basnett, J., Dela Pena, A., Juarez, J., Bradstock, K., Bendall, L. (2013). Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice. Experimental Hematology, 41(3), 293-302.e1. [More Information]
  • Saunders, P., Weiss, J., Welschinger, R., Baraz, R., Bradstock, K., Bendall, L. (2013). RAD001 (everolimus) induces dose-dependent changes to cell cycle regulation and modifies the cell cycle response to vincristine. Oncogene, 32(40), 4789-4797. [More Information]
  • Bendall, L., Basnett, J. (2013). Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. Current Opinion In Hematology, 20(4), 281-288. [More Information]

2012

  • Harun, N., Bradstock, K., Bendall, L. (2012). Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors. In Stefan Fruehauf, W. Jens Zeller and Gary Calandra (Eds.), Novel Developments in Stem Cell Mobilization, (pp. 37-54). New York: Springer Science + Business Media.
  • Wallington-Beddoe, C., Don, A., Hewson, J., Qiao, Q., Papa, R., Lock, R., Bradstock, K., Bendall, L. (2012). Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia. PLoS One, 7(5), 1-7. [More Information]
  • Klionsky, D., Abdalla, F., Abeliovich, H., Abraham, R., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J., Bendall, L., Feng, C., Sidhu, S., Xia, P., et al (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445-544. [More Information]
  • Winkler, I., Pettit, A., Raggatt, L., Jacobsen, R., Forristal, C., Barbier, V., Nowlan, B., Cisterne, A., Bendall, L., Sims, N., et al (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia, 26(7), 1594-1601. [More Information]
  • Khan, N., Cisterne, A., Baraz, R., Bradstock, K., Bendall, L. (2012). Para-NO-aspirin inhibits NF-kB and induces apoptosis in B-cell progenitor acute lymphoblastic leukemia. Experimental Hematology, 40(3), 207-215.e1. [More Information]
  • Juarez, J., Harun, N., Thien, M., Welschinger, R., Baraz, R., Dela Pena, A., Pitson, S., Rettig, M., DiPersio, J., Bradstock, K., Bendall, L. (2012). Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood, 119(3), 707-716. [More Information]

2011

  • Wallington-Beddoe, C., Hewson, J., Bradstock, K., Bendall, L. (2011). FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy, 7(7), 707-715. [More Information]
  • Bendall, L. (2011). It's all in the timing. Blood, 118(23), 5983-5984. [More Information]
  • To, L., Levesque, J., Herbert, K., Winkler, I., Bendall, L., Hiwase, D., Antonenas, V., Rice, A., Gottlieb, D., Mills, A., Rasko, J., et al (2011). Mobilisation strategies for normal and malignant cells. Pathology, 43(6), 547-565. [More Information]
  • Saunders, P., Cisterne, A., Weiss, J., Bradstock, K., Bendall, L. (2011). The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia. Haematologica: the hematology journal, 96(1), 69-77. [More Information]
  • Wei, J., Yee, C., Ramanathan, P., Bendall, L., Williamson, P. (2011). Variation in Immunophenotype of Lactating Mice. American Journal of Reproductive Immunology, 89, 178-184. [More Information]

2010

  • Sedger, L., Katewa, A., Petterson, A., Osvath, S., Farrell, G., Stewart, G., Bendall, L., Alexander, S. (2010). Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL- and TRAIL-double deficient mice. Blood, 115(16), 3258-3268. [More Information]
  • Bendall, L. (2010). New and Emerging Drug Targets for the Treatment of Hematological Malignancies. Current Drug Targets, 11(7), 767-8. [More Information]
  • Deo, S., Bendall, L. (2010). The Potential and Limitations of p38MAPK as a Drug Target for the Treatment of Hematological Malignancies. Current Drug Targets, 11(7), 823-833. [More Information]

2009

  • Juarez, J., Thien, M., Dela Pena, A., Baraz, R., Bradstock, K., Bendall, L. (2009). CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK. British Journal of Haematology, 145, 491-499. [More Information]
  • Crazzolara, R., Bendall, L. (2009). Emerging treatments in acute lymphoblastic leukemia. Current Cancer Drug Targets, 9(1), 19-31. [More Information]
  • Deo, S., Bradstock, K., Bendall, L. (2009). p38MAPK inhibitors attenuate cytokine production by bone marrow stromal cells and reduce stroma-mediated proliferation of acute lymphoblastic leukemia cells. Cell Cycle, 8(18), 2977-2985. [More Information]
  • Crazzolara, R., Cisterne, A., Thien, M., Hewson, J., Baraz, R., Bradstock, K., Bendall, L. (2009). Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. Blood, 113(14), 3297-3306. [More Information]
  • Crazzolara, R., Bradstock, K., Bendall, L. (2009). RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia. Autophagy, 5(5), 727-728. [More Information]
  • Johnson, M., Sharma, M., Jamieson, C., Henderson, J., Mok, M., Bendall, L., Henderson, B. (2009). Regulation of beta-catenin trafficking to the membrane in living cells. Cellular Signalling, 21(2), 339-348. [More Information]

2008

  • Khan, N., Cisterne, A., Devidas, M., Shuster, J., Hunger, S., Shaw, P., Bradstock, K., Bendall, L. (2008). Expression of CD44, but not CD44v6, predicts relapse in children with B cell progenitor acute lymphoblastic leukemia lacking adverse or favorable genetics. Leukemia and lymphoma, 49(4), 710-718. [More Information]

2007

  • Khan, N., Bradstock, K., Bendall, L. (2007). Activation of Wnt/beta-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia. British Journal of Haematology, 138(3), 338-348. [More Information]
  • Juarez, J., Dela Pena, A., Baraz, R., Hewson, J., Khoo, M., Cisterne, A., Fricker, S., Fujii, N., Bradstock, K., Bendall, L. (2007). CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment. Leukemia, 21(6), 1249-1257. [More Information]
  • Juarez, J., Baraz, R., Deo, S., Bradstock, K., Bendall, L. (2007). Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia. Haematologica: the hematology journal, 92(4), 450-459. [More Information]

2006

  • Belov, L., Mulligan, S., Barber, N., Woolfson, A., Scott, M., Stoner, K., Chrisp, J., Sewell, W., Bradstock, K., Bendall, L., Sartor, M., Young, G., Wiley, J., Christopherson, R., et al (2006). Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray. British Journal of Haematology, 135(2), 184-97. [More Information]
  • Christopherson, R., Stoner, K., Barber, N., Belov, L., Woolfson, A., Scott, M., Bendall, L., Mulligan, S. (2006). Classification of AML using a monoclonal antibody microarray. Methods in molecular medicine, 125, 241-251. [More Information]
  • Khan, N., Bendall, L. (2006). Role of WNT signaling in normal and malignant hematopoiesis. Histology and Histopathology: cellular and molecular biology, 21(7), 761-774. [More Information]

2005

  • Sedger, L., Bendall, L., Gottlieb, D., Alexander, S., Osvath, S. (2005). A novel mechanism of viral subversion of TNF-R signalling by the poxvirus TNF-R like protein, T2. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Bendall, L. (2005). Chemokines and their receptors in disease. Histology and Histopathology: cellular and molecular biology, 20(3), 907-926. [More Information]
  • Juarez, J., Hewson, J., Cisterne, A., Baraz, R., Bradstock, K., Bendall, L. (2005). CXCR4 antagonists mobilize acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment in mice. 47th Annual Meeting of the American Society of Hematology (ASH), United States: American Society of Hematology.
  • Bendall, L., Baraz, R., Juarez, J., Shen, W., Bradstock, K. (2005). Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia. Cancer Research. [More Information]
  • Campana, D., Iwamoto, D., Bendall, L., Bradstock, K. (2005). Growth requirements and immunophenotype of acute lymphoblastic leukemia progenitors. Blood, 105(10), 4150. [More Information]
  • Sloane, A., Raso, V., Dimitrov, D., Xiao, X., Deo, S., Muljadi, N., Restuccia, D., Turville, S., Kearney, C., Broder, C., Zoellner, H., Cunningham, A., Bendall, L., Lynch, G. (2005). Marked structural and functional heterogeneity in CXCR4: Separation of HIV-1 and SDF-1 alpha responses. Immunology and Cell Biology, 83(2), 129-143. [More Information]
  • Bendall, L., Bradstock, K. (2005). New therapies targeting chemokine receptors: Can changing the way cells traffic be used to treat human disease? Current Topics in Membranes, 55, 331-365.
  • Nilsson, S., Johnston, H., Whitty, G., Williams, B., Webb, R., Denhardt, D., Bertoncello, I., Bendall, L., Simmons, P., Haylock, D. (2005). Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood, 106(4), 1232-1239. [More Information]
  • Shaw, S., Haylock, D., Lock, R., Bendall, L., Simmons, P., Johnston, H., Fletcher, K., Webb, R., Brown, T., Liem, N., et al (2005). The role of hyaluronic acid in normal and perturbed hemopoietic stem cell biology. In E.A. Balazs and V.C. Hascall (Eds.), Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications, (pp. 293-299). New Jersey: Matrix Biology Inst.
  • Khan, N., Bradstock, K., Bendall, L. (2005). The Wnt/beta-catenin pathway promotes growth and survival of acute lymphoblastic leukaemia (ALL) cells in vitro. 47th Annual Meeting of the American Society of Hematology (ASH), United States: American Society of Hematology.

2004

  • Juarez, J., Bendall, L., Bradstock, K. (2004). Chemokines And Their Receptors As Therapeutic Targets: The Role Of The Sdf-1/Cxcr4 Axis. Current Pharmaceutical Design, 10(11), 1245-1259.
  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts. Breast Cancer Research and Treatment, 83(3), 211-220.
  • Bendall, L., Nilsson, S., Khan, N., James, A., Bonnet, C., Lock, R., Papa, R., Bradstock, K., Gottlieb, D. (2004). Role of CD44 variant exon 6 in acute lymphoblastic leukaemia: association with altered bone marrow localisation and increased tumor burden. Leukemia, 18(7), 1308-1311.
  • Juarez, J., Bendall, L. (2004). SDF-1 And CXCR4 In Normal And Malignant Hematopoiesis. Histology and Histopathology: cellular and molecular biology, 19(1), 299-309.

2003

  • Bendall, L., James, A., Zannettino, A., Simmons, P., Gottlieb, D., Bradstock, K. (2003). A novel CD44 antibody identifies an epitope that is aberrantly expressed on acute lymphoblastic leukaemia cells. Immunology and Cell Biology, 81(4), 311-319.
  • Lévesque, J., Hendy, J., Takamatsu, Y., Simmons, P., Bendall, L. (2003). Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. Journal of Clinical Investigation, 111(2), 187-196.
  • Juarez, J., Gottlieb, D., Bradstock, K., Bendall, L. (2003). Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia, 17(7), 1294-1300.
  • Zannettino, A., Roubelakis, M., Welldon, K., Jackson, D., Simmons, P., Bendall, L., Henniker, A., Harrison, K., Niutta, S., Bradstock, K., et al (2003). Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration. Biochemical Journal, 370(2), 537-549.

2002

  • Saad, S., Gottlieb, D., Bradstock, K., Overall, C., Bendall, L. (2002). Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts. Cancer Research, 62, 283-289.

2001

  • McQibban,, G., Butler,, G., Gong,, J., Bendall, L., Power, C., Clark-Lewis, I., Overall, M. (2001). Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. Journal of Biological Chemistry, 276(47), 43503-43508.
  • Shen, W., Bendall, L., Gottlieb, D., Bradstock, K. (2001). The chemokine receptor CXCR4 enhances integrin mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow. Experimental Hematology, 29(12), 1439-1447.

2000

  • Bendall, L., Bradstock, K., Gottlieb, D. (2000). Expression of CD44 variant exons in acute myeloid leukemia is more common and more complex than that observed in normal blood, bone marrow or CD34+ cells. Leukemia, 14(7), 1239-1246.
  • Gu, B., Zhang, W., Bendall, L., Chessell, I., Buell, G., Wiley, J. (2000). Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors. American Journal of Physiology: Cell Physiology, 279(4), C1189-C1197.
  • Saad, S., Bendall, L., James, A., Gottlieb, D., Bradstock, K. (2000). Induction of matrix metalloproteinases MMP-1 and MMP-2 by co-culture of breast cancer cells and bone marrow fibroblasts. Breast Cancer Research and Treatment, 63(2), 105-115.

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