People_

Dr Ling Zhu

Senior Research Fellow
Save Sight Institute
Faculty of Medicine and Health

Phone

+61 2 9382 7289

[email protected]

Details

Member of The Drug Discovery Initiative

Member of The University of Sydney Nano Institute

Websites

Save Sight Institute

Biographical details

Dr Ling Zhu obtained his PhD from the Department of Biochemistry, Rutgers (USA) in 2008 and joined the Macula Research Group in Save Sight Institute to continue his career at the interface of clinical and basic research. He is now the head of the lab unit leading one postdoc, two research assistants and one HDR student. Dr Zhu has established a diverse array of techniques, which have greatly facilitated several projects in studying the cellular and molecular pathogenesis of debilitating retinal diseases such as diabetic retinopathy, age-related macular degeneration and macular telangiectasia type 2. He successfully attracted more than 2M dollars of research funding in the past five years. Dr Zhu has broad knowledge and well-established skills in Biochemistry and Molecular biology. He has established human retinal explants, which is the unique ex vivo model required in the proposed study. Dr Zhu has a career total of 93 publications, 40 within the past five years, with 3590 citations, H-index 34 (14 years post-PhD). Dr Zhu is the major author of most of these papers published in the leading journals in the field, such as eLife and Ophthalmology.

Research interests

Human retinal explant culture; Macula; Nanomedicine in ophthalmology

Current projects

Preclinical study of delivering RNA-LNPs to treat retinal degeneration
Targeting retinal metabolism to treat macular diseases
Targeting human Muller cells to prevent retinal fibrosis
Macula-on-a-Chip: a novel drug screen and development platform.

Current research students

Project title	Research student
Diversity of Amacrine Cells in the Retina	Alyssa Kristina BALDICANO
NRF2/MAFF RNA-based drug delivered by lipid nanoparticles for treating macular degeneration	Jialing ZHANG

Publications

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Book Chapters

Zhang, T., Bahrami, B., Zhu, L. (2018). Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina. In Alexzander A. A. Asea, Punit Kaur (Eds.), HSP70 in human diseases and disorders, (pp. 273-287). Cham: Springer. [More Information]

Journals

Li, Y., Zhu, X., Wang, K., Zhu, L., Murray, M., Zhou, F. (2023). Ginkgo biloba extracts (GBE) protect human RPE cells from t-BHP-induced oxidative stress and necrosis by activating the Nrf2-mediated antioxidant defence. Journal of Pharmacy and Pharmacology, 75(1), 105-116. [More Information]
Li, Y., Wang, K., Zhu, X., Cheng, Z., Zhu, L., Murray, M., Zhou, F. (2023). Ginkgo biloba extracts protect human retinal Müller glial cells from t-BHP induced oxidative damage by activating the AMPK-Nrf2-NQO-1 axis. Journal of Pharmacy and Pharmacology, 75(3), 385-396. [More Information]
Cheng, J., Lin, G., Wang, T., Wang, Y., Guo, W., Liao, J., Yang, P., Chen, J., Shao, X., Lu, X., Zhu, L., Fan, X., et al (2023). Massively Parallel CRISPR-Based Genetic Perturbation Screening at Single-Cell Resolution. Advanced Science, 10(4). [More Information]
Zeng, S., Chen, Y., Zhou, F., Zhang, T., Fan, X., Chrzanowski, W., Gillies, M., Zhu, L. (2023). Recent advances and prospects for lipid-based nanoparticles as drug carriers in the treatment of human retinal diseases. Advanced Drug Delivery Reviews, 199, 114965. [More Information]
Zhang, J., Zhang, T., Zeng, S., Zhang, X., Zhou, F., Gillies, M., Zhu, L. (2023). The Role of Nrf2/sMAF Signalling in Retina Ageing and Retinal Diseases. Biomedicines, 11(6), 1512. [More Information]
Cheng, Z., Li, Y., Wang, K., Zhu, X., Tharkar, P., Shu, W., Zhang, T., Zeng, S., Zhu, L., Murray, M., Chrzanowski, W., Zhou, F. (2022). Compritol solid lipid nanoparticle formulations enhance the protective effect of betulinic acid derivatives in human Müller cells against oxidative injury. Experimental Eye Research, 215, 108906. [More Information]
Zeng, S., Zhang, T., Chen, Y., Chu-Tan, J., Jin, K., Lee, S., Yam, M., Madigan, M., Fernando, N., Cioanca, A., Zhou, F., Zhu, M., Zhu, L., Gillies, M., et al (2022). Inhibiting the activation of MAPK (ERK1/2) in stressed Möller cells prevents photoreceptor degeneration. Theranostics, 12(15), 6705-6722. [More Information]
Chen, Y., Coorey, N., Zhang, M., Zeng, S., Madigan, M., Zhang, X., Gillies, M., Zhu, L., Zhang, T. (2022). Metabolism Dysregulation in Retinal Diseases and Related Therapies. Antioxidants, 11(5), 942. [More Information]
Wu, X., Tao, M., Zhu, L., Zhang, T., Zhang, M. (2022). Pathogenesis and current therapies for non-infectious uveitis. Clinical and Experimental Medicine. [More Information]
Niu, Y., Wang, K., Zhu, X., Zhang, S., Cherepanoff, S., Conway, R., Madigan, M., Lim, L., Zhu, L., Murray, M., Zhou, F. (2022). The application of natural compounds in uveal melanoma drug discovery. Journal of Pharmacy and Pharmacology, 74(5), 660-680. [More Information]
Shu, W., Zhu, X., Wang, K., Cherepanoff, S., Conway, R., Madigan, M., Zhu, H., Zhu, L., Murray, M., Zhou, F. (2022). The multi-kinase inhibitor afatinib serves as a novel candidate for the treatment of human uveal melanoma. Cellular Oncology, 45(4), 601-619. [More Information]
Li, Y., Zhu, X., Wang, K., Zhu, L., Murray, M., Zhou, F. (2022). The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2-mediated antioxidant protection. Journal of Pharmacy and Pharmacology, 74(12), 1689-1699. [More Information]
Zhang, S., Wang, K., Zhu, X., Cherepanoff, S., Conway, R., Madigan, M., Zhu, L., Murray, M., Zhou, F. (2022). The unfolded protein response and the biology of uveal melanoma. Biochimie, 197, 9-18. [More Information]
Chen, Y., Zhang, T., Zeng, S., Xu, R., Jin, K., Coorey, N., Wang, Y., Wang, K., Lee, S., Yam, M., Zhu, M., Chang, A., Fan, X., Gillies, M., Zhu, L., et al (2022). Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways. Redox Biology, 54, 102379. [More Information]
Wang, Q., Zhang, X., Wang, K., Zhu, L., Qiu, B., Chen, X., Lin, X., Nie, Y. (2021). An in Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration. Journal of Diabetes Research, 2021, 9765119. [More Information]
Shen, W., Lee, S., Mathai, A., Zhang, R., Du, J., Yam, M., Pye, V., Barnett, N., Rayner, C., Zhu, L., et al (2021). Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health. GLIA, 69(8), 1966-1986. [More Information]
Wang, K., Ni, J., Zhu, X., Zhu, L., Li, Y., Zhou, F. (2021). Ginkgo biloba extract protects human neuroblastoma SH-SY5Y cells against oxidative glutamate toxicity by activating redoxosome-p66Shc. Experimental and Therapeutic Medicine, 22(3), 951. [More Information]
Chen, Y., Zhang, T., Zeng, S., Yam, M., Gillies, M., Zhu, L. (2021). Isolation, culture, and identification of primary Müller cells from human retina. Bio-protocol, 11(19), e4179. [More Information]
Zhang, X., Wang, K., Zhu, L., Wang, Q. (2021). Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy. Journal of Diabetes Research, 2021, 8746114. [More Information]
Cheng, Z., Li, Y., Zhu, X., Wang, K., Ali, Y., Shu, W., Zhang, T., Zhu, L., Murray, M., Zhou, F. (2021). The Potential Application of Pentacyclic Triterpenoids in the Prevention and Treatment of Retinal Diseases. Planta Medica: natural products and medicinal plant research, 87(7), 511-527. [More Information]
Liao, J., Lu, X., Shao, X., Zhu, L., Fan, X. (2021). Uncovering an Organ's Molecular Architecture at Single-Cell Resolution by Spatially Resolved Transcriptomics. Trends in Biotechnology, 39(1), 43-58. [More Information]
Zhu, X., Yu, M., Wang, K., Zou, W., Zhu, L. (2020). FoxM1 affects adhesive, migratory, and invasive abilities of human retinoblastoma Y-79 cells by targeting matrix metalloproteinase 2. Acta Biochimica et Biophysica Sinica, 52(3), 294-301. [More Information]
Li, B., Zhang, T., Liu, W., Wang, Y., Xu, R., Zeng, S., Zhang, R., Zhu, S., Gillies, M., Zhu, L., et al (2020). Metabolic Features of Mouse and Human Retinas: Rods versus Cones, Macula versus Periphery, Retina versus RPE. iScience, 23(11), 101672. [More Information]
Ali, Y., Shams, T., Wang, K., Cheng, Z., Li, Y., Shu, W., Bao, X., Zhu, L., Murray, M., Zhou, F. (2020). The involvement of human organic anion transporting polypeptides (OATPs) in drug-herb/food interactions. Chinese Medicine, 15(1), 1-10. [More Information]
Cheng, Z., Yao, W., Zheng, J., Ding, W., Wang, Y., Zhang, T., Zhu, L., Zhou, F. (2019). A derivative of betulinic acid protects human Retinal Pigment Epithelial (RPE) cells from cobalt chloride-induced acute hypoxic stress. Experimental Eye Research, 180, 92-101. [More Information]
Lukowski, S., Lo, C., Sharov, A., Nguyen, Q., Fang, L., Hung, S., Zhu, L., Zhang, T., Grunert, U., Nguyen, T., Gillies, M., et al (2019). A single-cell transcriptome atlas of the adult human retina. EMBO Journal, 38(18), 1-15. [More Information]
Cheng, Z., Zhang, T., Zheng, J., Ding, W., Wang, Y., Li, Y., Zhu, L., Murray, M., Zhou, F. (2019). Betulinic acid derivatives can protect human Muller cells from glutamate-induced oxidative stress. Experimental Cell Research, 383(1), 1-8. [More Information]
Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Zhu, L., Fraser, C., Graham, S., Klistorner, A., et al (2019). Differing Structural and Functional Patterns of Optic Nerve Damage in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder. Ophthalmology, 126(3), 445-453. [More Information]
Bahrami, B., Shen, W., Zhu, L., Zhang, T., Chang, A., Gillies, M. (2019). Effects of VEGF inhibitors on human retinal pigment epithelium under high glucose and hypoxia. Clinical and Experimental Ophthalmology, 47(8), 1074-1081. [More Information]
You, Y., Zhu, L., Zhang, T., Shen, T., Fontes, A., Yiannikas, C., Parratt, J., Barton, J., Schulz, A., Gupta, V., Barnett, M., Fraser, C., Gillies, M., Graham, S., Klistorner, A. (2019). Evidence of Muller Glial Dysfunction in Patients with Aquaporin-4 Immunoglobulin G-Positive Neuromyelitis Optica Spectrum Disorder. Ophthalmology, 126(6), 801-810. [More Information]
Zhang, T., Zhu, L., Madigan, M., Liu, W., Shen, W., Cherepanoff, S., Zhou, F., Zeng, S., Du, J., Gillies, M. (2019). Human macular Muller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery. eLife, 8, 1-19. [More Information]
Zhang, T., Gillies, M., Wang, Y., Shen, W., Bahrami, B., Zeng, S., Zhu, M., Yao, W., Zhou, F., Murray, M., Zhu, L., et al (2019). Simvastatin Protects Photoreceptors from all-trans-retinal Induced Oxidative Stress with Up-regulation of Interphotoreceptor Retinoid Binding Protein. British Journal of Pharmacology, 176(12), 2063-2078. [More Information]
Shen, W., Lee, S., Yam, M., Zhu, L., Zhang, T., Pye, V., Mathai, A., Shibagaki, K., Zhang, J., Matsugi, T., Gillies, M. (2018). A Combination Therapy Targeting Endoglin and VEGF-A Prevents Subretinal Fibro-Neovascularization Caused by Induced Muller Cell Disruption. Investigative Ophthalmology and Visual Science, 59(15), 6075-6088. [More Information]
Zhu, L., Shen, W., Zhang, T., Wang, Y., Bahrami, B., Zhou, F., Gillies, M. (2018). Characterization of canonical Wnt signalling changes after induced disruption of Muller cell in murine retina. Experimental Eye Research, 175, 173-180. [More Information]
Wang, K., Zhu, X., Yao, Y., Yang, M., Zhou, F., Zhu, L. (2018). Corosolic acid induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells via disruption of MELK-FoxM1 signaling. Oncology Reports, 39(6), 2777-2786. [More Information]
Zhang, T., Gillies, M., Madigan, M., Shen, W., Du, J., Grunert, U., Zhou, F., Yam, M., Zhu, L. (2018). Disruption of De Novo Serine Synthesis in MÃ¼ller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage. Molecular Neurobiology, 55(8), 7025-7037. [More Information]
Zhu, X., Wang, K., Zhou, F., Zhu, L. (2018). Paeoniflorin attenuates atRAL-induced oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca2+/CaMKII-dependent activation of AMPK. Archives of Pharmacal Research, 41(10), 1009-1018. [More Information]
Zhu, X., Wang, K., Zhang, K., Pan, Y., Zhou, F., Zhu, L. (2018). Polyphyllin i induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells through targeting p53. Anti-Cancer Agents in Medicinal Chemistry, 18(6), 875-881. [More Information]
Lu, X., Chan, T., Cheng, Z., Shams, T., Zhu, L., Murray, M., Zhou, F. (2018). The 5'-AMP-activated protein kinase (AMPK) regulates the function and expression of human Organic Anion Transporting Polypeptide 1A2. Molecular Pharmacology, 94(6), 1412-1420. [More Information]
Zhou, F., Zhu, L., Zhu, X., Xue, L., Yao, Y., Wang, K., Tan, C., Zhuang, M. (2018). The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells. Acta Biochimica et Biophysica Sinica, 50(9), 914-920. [More Information]
Lu, X., Chan, T., Zhu, L., Bao, X., Velkov, T., Zhou, Q., Li, J., Chan, H., Zhou, F. (2018). The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models. European Journal of Pharmaceutical Sciences, 115, 132-143. [More Information]
Shams, T., Lu, X., Zhu, L., Zhou, F. (2018). The inhibitory effects of five alkaloids on the substrate transport mediated through human organic anion and cation transporters. Xenobiotica, 48(2), 197-205. [More Information]
Zhu, X., Wang, K., Yao, Y., Zhang, K., Zhou, F., Zhu, L. (2018). Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis. Journal of Biochemical and Molecular Toxicology, 32(1), 1-7. [More Information]
Wang, K., Yao, Y., Zhu, X., Zhang, K., Zhou, F., Zhu, L. (2017). Amyloid B induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production. Journal of Biochemical and Molecular Toxicology, 31(6), 1-5. [More Information]
Shen, W., Yau, B., Lee, S., Zhu, L., Yam, M., Gillies, M. (2017). Effects of Ranibizumab and Aflibercept on Human Muller Cells and Photoreceptors under Stress Conditions. International Journal of Molecular Sciences, 18(3), 1-16. [More Information]
Wang, K., Zhu, X., Zhang, K., Zhou, F., Zhu, L. (2017). Neuroprotective effect of tetramethylpyrazine against all-trans-retinal toxicity in the differentiated Y-79 cells via upregulation of IRBP expression. Experimental Cell Research, 359(1), 120-128. [More Information]
Wang, K., Zhu, X., Zhang, K., Yao, Y., Zhuang, M., Tan, C., Zhou, F., Zhu, L. (2017). Puerarin inhibits amyloid (beta)-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. Experimental Cell Research, 357(2), 335-340. [More Information]
Zhou, F., Zhu, L., Wang, K., Murray, M. (2017). Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition. Advanced Drug Delivery Reviews, 116, 21-36. [More Information]
Chan, T., Cheung, F., Zheng, J., Lu, X., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2016). Casein Kinase 2 Is a Novel Regulator of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Trafficking. Molecular Pharmaceutics, 13(1), 144-154. [More Information]
Xu, C., Zhu, L., Chan, T., Lu, X., Shen, W., Madigan, M., Gillies, M., Zhou, F. (2016). Chloroquine and Hydroxychloroquine Are Novel Inhibitors of Human Organic Anion Transporting Polypeptide 1A2. Journal of Pharmaceutical Sciences, 105(2), 884-890. [More Information]
Wang, K., Zhu, X., Zhang, K., Zhu, L., Zhou, F. (2016). FoxM1 inhibition enhances chemosensitivity of docetaxel-resistant A549 cells to docetaxel via activation of JNK/mitochondrial pathway. Acta Biochimica et Biophysica Sinica, 48(9), 804-809. [More Information]
Zhu, X., Wang, K., Zhang, K., Xu, F., Yin, Y., Zhu, L., Zhou, F. (2016). Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression. Acta Biochimica et Biophysica Sinica, 48(5), 462-467. [More Information]
Wang, K., Zhu, X., Zhang, K., Zhou, F., Zhu, L. (2016). Gas1 Knockdown Increases the Neuroprotective Effect of Glial Cell-Derived Neurotrophic Factor Against Glutamate-Induced Cell Injury in Human SH-SY5Y Neuroblastoma Cells. Cellular and Molecular Neurobiology, 36(4), 603-611. [More Information]
Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, H., Li, J., Zhou, F. (2016). Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins. Journal of Antimicrobial Chemotherapy, 71(2), 403-412. [More Information]
Zhu, X., Wang, K., Zhang, K., Zhou, F., Zhu, L. (2016). Induction of oxidative and nitrosative stresses in human retinal pigment epithelial cells by all-trans-retinal. Experimental Cell Research, 348(4), 87-94. [More Information]
Wang, K., Zhu, X., Zhang, K., Wu, Z., Sun, S., Zhou, F., Zhu, L. (2016). Neuroprotective effect of Puerarin on glutamate-induced cytotoxicity in differentiated Y-79 cells via inhibition of ROS generation and Ca2+ influx. International Journal of Molecular Sciences, 17(7), 1-13. [More Information]
Zhu, X., Wang, K., Zhang, K., Lin, X., Zhu, L., Zhou, F. (2016). Puerarin Protects Human Neuroblastoma SH-SY5Y Cells against Glutamate-Induced Oxidative Stress and Mitochondrial Dysfunction. Journal of Biochemical and Molecular Toxicology, 30(1), 22-28. [More Information]
Zheng, J., Chan, T., Zhu, L., Yan, X., Cao, Z., Wang, Y., Zhou, F. (2016). The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs). Xenobiotica, 46(9), 831-840. [More Information]
Chan, T., Lu, X., Shams, T., Zhu, L., Murray, M., Zhou, F. (2016). The Role of N-Glycosylation in Maintaining the Transporter Activity and Expression of Human Oligopeptide Transporter 1. Molecular Pharmaceutics, 13(10), 3449-3456. [More Information]
Wang, K., Xie, M., Zhu, L., Zhu, X., Zhang, K., Zhou, F. (2015). Ciliary neurotrophic factor protects SH-SY5Y neuroblastoma cells against A-Beta1-42-induced neurotoxicity via activating the JAK2/STAT3 axis. Folia Neuropathologica, 53(3), 226-235. [More Information]
Coorey, N., Shen, W., Zhu, L., Gillies, M. (2015). Differential Expression of IL-6/gp130 Cytokines, Jak-STAT Signalling and Neuroprotection After Muller Cell Ablation in a Transgenic Mouse Model. Investigative Ophthalmology and Visual Science, 56(4), 2151-2161. [More Information]
Zhu, L., Shen, W., Lyons, B., Wang, Y., Zhou, F., Gillies, M. (2015). Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Muller cell disruption. Journal of Neurochemistry, 133(6), 909-918. [More Information]
Zhu, X., Liu, A., Zhang, K., Wang, K., Gao, Y., Zhou, F., Zhu, L. (2015). High-yield soluble expression of recombinant human interleukin-1Î² in Escherichia coli. Romanian Biotechnology Letters, 20(1), 10114-10122.
Chan, T., Zhu, L., Madigan, M., Wang, K., Shen, W., Gillies, M., Zhou, F. (2015). Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells. British Journal of Pharmacology, 172(9), 2343-2353. [More Information]
Chung, S., Gillies, M., Sugiyama, Y., Zhu, L., Lee, S., Shen, W. (2015). Profiling of MicroRNAs Involved in Retinal Degeneration Caused by Selective MÃ¼ller Cell Ablation. PloS One, 10(3), 1-18. [More Information]
Chan, T., Zheng, J., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2015). Putative Transmembrane Domain 6 of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Influences Transporter Substrate Binding, Protein Trafficking, and Quality Control. Molecular Pharmaceutics, 12(1), 111-119. [More Information]
Zhu, X., Wang, K., Zhang, K., Tan, X., Wu, Z., Sun, S., Zhou, F., Zhu, L. (2015). Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1B-Induced Nitrative/Oxidative Stress. International Journal of Molecular Sciences, 16(9), 21775-21790. [More Information]
Xu, C., Zhu, L., Chan, T., Lu, X., Shen, W., Gillies, M., Zhou, F. (2015). The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice. PloS One, 10(3), 1-14. [More Information]
Tan, X., Sun, S., Liu, Y., Zhu, T., Wang, K., Ren, T., Wu, Z., Xu, H., Zhu, L. (2014). Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome. Eye, 28(5), 608-613. [More Information]
Barthelmes, D., Zhu, L., Shen, W., Gillies, M., Irhimeh, M. (2014). Differential gene expression in Lin-/VEGF-R2+ bone marrow-derived endothelial progenitor cells isolated from diabetic mice. Cardiovascular Diabetology, 13(1), 1-10. [More Information]
Shen, W., Lee, S., Araujo, J., Chung, S., Zhu, L., Gillies, M. (2014). Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Muller cell ablation. GLIA, 62(7), 1110-1124. [More Information]
Wang, K., Zhou, F., Zhu, L., Zhu, X., Zhang, K., Zhu, L. (2014). High level soluble expression, purification, and characterization of human ciliary neruonotrophic factor in Escherichia coli by single protein production system. Protein Expression and Purification, 96, 8-13. [More Information]
Li, Z., Cheung, F., Zheng, J., Chan, T., Zhu, L., Zhou, F. (2014). Interaction of the Bioactive Flavonol, Icariin, with the Essential Human Solute Carrier Transporters. Journal of Biochemical and Molecular Toxicology, 28(2), 91-97. [More Information]
Li, Z., Wang, K., Zheng, J., Cheung, F., Chan, T., Zhu, L., Zhou, F. (2014). Interactions of the active components of Punica granatum (pomegranate) with the essential renal and hepatic human Solute Carrier transporters. Pharmaceutical Biology, 52(12), 1510-1517. [More Information]
Wang, K., Zhu, X., Zhang, K., Zhu, L., Zhou, F. (2014). Investigation of gallic acid induced anticancer effect in human breast carcinoma MCF-7 cells. Journal of Biochemical and Molecular Toxicology, 28(9), 387-393. [More Information]
Wang, K., Zhou, F., Zhu, X., Zhang, K., Huang, B., Zhu, L., Zhu, L. (2014). Neuroprotective properties of ciliary neurotrophic factor on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells. Folia Neuropathologica, 52(2), 121-127. [More Information]
Zheng, J., Chan, T., Cheung, F., Zhu, L., Murray, M., Zhou, F. (2014). PDZK1 and NHERF1 Regulate the Function of Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) by Modulating Its Subcellular Trafficking and Stability. PloS One, 9(4), 1-11. [More Information]
Wang, K., Zhu, L., Zhu, X., Zhang, K., Huang, B., Zhang, J., Zhang, Y., Zhu, L., Zhou, B., Zhou, F. (2014). Protective Effect of Paeoniflorin on AB 25-35- Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction. Cellular and Molecular Neurobiology, 34(2), 227-234. [More Information]
Zhu, X., Xie, M., Wang, K., Zhang, K., Gao, Y., Zhu, L., Zhou, F. (2014). The effect of puerarin against IL-1B-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). Molecular Vision, 20, 1815-1823.
Wang, K., Zhang, K., Lv, Z., Zhu, X., Zhu, L., Zhou, F. (2014). Ultrasensitive detection of microRNA with isothermal amplification and a time-resolved fluorescence sensor. Biosensors and Bioelectronics, 57, 91-95. [More Information]
Zhu, X., Wang, K., Zhang, K., Zhu, L., Zhou, F. (2014). Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicology Letters, 227(1), 65-73. [More Information]
Zhu, L., Shen, W., Zhu, M., Coorey, N., Nguyen, A., Barthelmes, D., Gillies, M. (2013). Anti-Retinal Antibodies in Patients With Macular Telangiectasia Type 2. Investigative Ophthalmology and Visual Science, 54(8), 5675-5683. [More Information]
Barthelmes, D., Irhimeh, M., Gillies, M., Karimipour, M., Zhou, M., Zhu, L., Shen, W. (2013). Diabetes impairs mobilization of mouse bone marrow-derived Lin-/VEGF-R2+ progenitor cells. Blood Cells, Molecules and Diseases, 51(3), 163-173. [More Information]
Zhou, F., Zheng, J., Zhu, L., Jodal, A., Cui, P., Wong, K., Gurney, H., Church, W., Murray, M. (2013). Functional Analysis of Novel Polymorphisms in the Human SLCO1A2 Gene that Encodes the Transporter OATP1A2. The AAPS Journal, 15(4), 1099-1108. [More Information]
Chan, T., Li, Z., Zheng, J., Cheung, F., Zhu, L., Zhou, F. (2013). Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters. World Journal of Pharmacology, 2(4), 115-121. [More Information]
Shen, W., Zhu, L., Lee, S., Chung, S., Gillies, M. (2013). Involvement of NT3 and P75NTR in photoreceptor degeneration following selective Muller cell ablation. Journal of Neuroinflammation, 10(137), 1-13. [More Information]
Barthelmes, D., Irhimeh, M., Gillies, M., Zhu, L., Shen, W. (2013). Isolation and characterization of mouse bone marrow-derived Lin-/VEGF-R2+ progenitor cells. Annals of Hematology, 92(11), 1461-1472. [More Information]
Xu, F., Li, Z., Zheng, J., Cheung, F., Chan, T., Zhu, L., Zhuge, H., Zhou, F. (2013). The Inhibitory Effects of the Bioactive Components Isolated from Scutellaria Baicalensis on the Cellular Uptake Mediated by the Essential Solute Carrier Transporters. Journal of Pharmaceutical Sciences, 102(11), 4205-4211. [More Information]
Shen, W., Fruttiger, M., Zhu, L., Chung, S., Barnett, N., Kirk, J., Lee, S., Coorey, N., Killingsworth, M., Sherman, L., Gillies, M. (2012). Conditional Muller Cell Ablation Causes Independent Neuronal and Vascular Pathologies in a Novel Transgenic Model. Journal of Neuroscience, 32(45), 15715-15727. [More Information]
Zhou, F., Li, Z., Lam, P., Zhu, L., Wang, K. (2012). Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs). Journal of Pharmacogenomics & Pharmacoproteomics, 3(6), 1-8. [More Information]
Len, A., Powner, M., Zhu, L., Hageman, G., Song, X., Fruttiger, M., Gillies, M. (2012). Pilot Application of iTRAQ to the Retinal Disease Macular Telangiectasia. Journal of Proteome Research, 11(2), 537-553. [More Information]
Coorey, N., Shen, W., Chung, S., Zhu, L., Gillies, M. (2012). The role of glia in retinal vascular disease. Clinical and Experimental Optometry, 95(3), 266-281. [More Information]
Irhimeh, M., Shen, W., Chung, S., Zhu, L., Barthelmes, D., Gillies, M. (2011). Erythropoetin treatment recruits pECFCs from the marrow into the blood and stabilizes retinal vasculature. Experimental Hematology, 39(8), S77-S78.
Zhou, F., Lee, A., Krafczyk, K., Zhu, L., Murray, M. (2011). Protein Kinase C Regulates the Internalization and Function of the Human Organic Anion Transporting Polypeptide 1A2. British Journal of Pharmacology, 162(6), 1380-1388. [More Information]
Shen, W., Li, S., Chung, S., Zhu, L., Stayt, J., Su, T., Couraud, P., Romero, I., Weksler, B., Gillies, M. (2011). Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-Î²1-induced permeability of centrally derived vascular endothelium. European Journal of Cell Biology, 90(4), 323-332. [More Information]
Zhou, F., Zhu, L., Cui, P., Church, W., Murray, M. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). British Journal of Pharmacology, 159, 419-427. [More Information]

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2023

Li, Y., Zhu, X., Wang, K., Zhu, L., Murray, M., Zhou, F. (2023). Ginkgo biloba extracts (GBE) protect human RPE cells from t-BHP-induced oxidative stress and necrosis by activating the Nrf2-mediated antioxidant defence. Journal of Pharmacy and Pharmacology, 75(1), 105-116. [More Information]
Li, Y., Wang, K., Zhu, X., Cheng, Z., Zhu, L., Murray, M., Zhou, F. (2023). Ginkgo biloba extracts protect human retinal Müller glial cells from t-BHP induced oxidative damage by activating the AMPK-Nrf2-NQO-1 axis. Journal of Pharmacy and Pharmacology, 75(3), 385-396. [More Information]
Cheng, J., Lin, G., Wang, T., Wang, Y., Guo, W., Liao, J., Yang, P., Chen, J., Shao, X., Lu, X., Zhu, L., Fan, X., et al (2023). Massively Parallel CRISPR-Based Genetic Perturbation Screening at Single-Cell Resolution. Advanced Science, 10(4). [More Information]
Zeng, S., Chen, Y., Zhou, F., Zhang, T., Fan, X., Chrzanowski, W., Gillies, M., Zhu, L. (2023). Recent advances and prospects for lipid-based nanoparticles as drug carriers in the treatment of human retinal diseases. Advanced Drug Delivery Reviews, 199, 114965. [More Information]
Zhang, J., Zhang, T., Zeng, S., Zhang, X., Zhou, F., Gillies, M., Zhu, L. (2023). The Role of Nrf2/sMAF Signalling in Retina Ageing and Retinal Diseases. Biomedicines, 11(6), 1512. [More Information]

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2022

Cheng, Z., Li, Y., Wang, K., Zhu, X., Tharkar, P., Shu, W., Zhang, T., Zeng, S., Zhu, L., Murray, M., Chrzanowski, W., Zhou, F. (2022). Compritol solid lipid nanoparticle formulations enhance the protective effect of betulinic acid derivatives in human Müller cells against oxidative injury. Experimental Eye Research, 215, 108906. [More Information]
Zeng, S., Zhang, T., Chen, Y., Chu-Tan, J., Jin, K., Lee, S., Yam, M., Madigan, M., Fernando, N., Cioanca, A., Zhou, F., Zhu, M., Zhu, L., Gillies, M., et al (2022). Inhibiting the activation of MAPK (ERK1/2) in stressed Möller cells prevents photoreceptor degeneration. Theranostics, 12(15), 6705-6722. [More Information]
Chen, Y., Coorey, N., Zhang, M., Zeng, S., Madigan, M., Zhang, X., Gillies, M., Zhu, L., Zhang, T. (2022). Metabolism Dysregulation in Retinal Diseases and Related Therapies. Antioxidants, 11(5), 942. [More Information]
Wu, X., Tao, M., Zhu, L., Zhang, T., Zhang, M. (2022). Pathogenesis and current therapies for non-infectious uveitis. Clinical and Experimental Medicine. [More Information]
Niu, Y., Wang, K., Zhu, X., Zhang, S., Cherepanoff, S., Conway, R., Madigan, M., Lim, L., Zhu, L., Murray, M., Zhou, F. (2022). The application of natural compounds in uveal melanoma drug discovery. Journal of Pharmacy and Pharmacology, 74(5), 660-680. [More Information]
Shu, W., Zhu, X., Wang, K., Cherepanoff, S., Conway, R., Madigan, M., Zhu, H., Zhu, L., Murray, M., Zhou, F. (2022). The multi-kinase inhibitor afatinib serves as a novel candidate for the treatment of human uveal melanoma. Cellular Oncology, 45(4), 601-619. [More Information]
Li, Y., Zhu, X., Wang, K., Zhu, L., Murray, M., Zhou, F. (2022). The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2-mediated antioxidant protection. Journal of Pharmacy and Pharmacology, 74(12), 1689-1699. [More Information]
Zhang, S., Wang, K., Zhu, X., Cherepanoff, S., Conway, R., Madigan, M., Zhu, L., Murray, M., Zhou, F. (2022). The unfolded protein response and the biology of uveal melanoma. Biochimie, 197, 9-18. [More Information]
Chen, Y., Zhang, T., Zeng, S., Xu, R., Jin, K., Coorey, N., Wang, Y., Wang, K., Lee, S., Yam, M., Zhu, M., Chang, A., Fan, X., Gillies, M., Zhu, L., et al (2022). Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways. Redox Biology, 54, 102379. [More Information]

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2021

Wang, Q., Zhang, X., Wang, K., Zhu, L., Qiu, B., Chen, X., Lin, X., Nie, Y. (2021). An in Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration. Journal of Diabetes Research, 2021, 9765119. [More Information]
Shen, W., Lee, S., Mathai, A., Zhang, R., Du, J., Yam, M., Pye, V., Barnett, N., Rayner, C., Zhu, L., et al (2021). Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health. GLIA, 69(8), 1966-1986. [More Information]
Wang, K., Ni, J., Zhu, X., Zhu, L., Li, Y., Zhou, F. (2021). Ginkgo biloba extract protects human neuroblastoma SH-SY5Y cells against oxidative glutamate toxicity by activating redoxosome-p66Shc. Experimental and Therapeutic Medicine, 22(3), 951. [More Information]
Chen, Y., Zhang, T., Zeng, S., Yam, M., Gillies, M., Zhu, L. (2021). Isolation, culture, and identification of primary Müller cells from human retina. Bio-protocol, 11(19), e4179. [More Information]
Zhang, X., Wang, K., Zhu, L., Wang, Q. (2021). Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy. Journal of Diabetes Research, 2021, 8746114. [More Information]
Cheng, Z., Li, Y., Zhu, X., Wang, K., Ali, Y., Shu, W., Zhang, T., Zhu, L., Murray, M., Zhou, F. (2021). The Potential Application of Pentacyclic Triterpenoids in the Prevention and Treatment of Retinal Diseases. Planta Medica: natural products and medicinal plant research, 87(7), 511-527. [More Information]
Liao, J., Lu, X., Shao, X., Zhu, L., Fan, X. (2021). Uncovering an Organ's Molecular Architecture at Single-Cell Resolution by Spatially Resolved Transcriptomics. Trends in Biotechnology, 39(1), 43-58. [More Information]

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2020

Zhu, X., Yu, M., Wang, K., Zou, W., Zhu, L. (2020). FoxM1 affects adhesive, migratory, and invasive abilities of human retinoblastoma Y-79 cells by targeting matrix metalloproteinase 2. Acta Biochimica et Biophysica Sinica, 52(3), 294-301. [More Information]
Li, B., Zhang, T., Liu, W., Wang, Y., Xu, R., Zeng, S., Zhang, R., Zhu, S., Gillies, M., Zhu, L., et al (2020). Metabolic Features of Mouse and Human Retinas: Rods versus Cones, Macula versus Periphery, Retina versus RPE. iScience, 23(11), 101672. [More Information]
Ali, Y., Shams, T., Wang, K., Cheng, Z., Li, Y., Shu, W., Bao, X., Zhu, L., Murray, M., Zhou, F. (2020). The involvement of human organic anion transporting polypeptides (OATPs) in drug-herb/food interactions. Chinese Medicine, 15(1), 1-10. [More Information]

2019

Cheng, Z., Yao, W., Zheng, J., Ding, W., Wang, Y., Zhang, T., Zhu, L., Zhou, F. (2019). A derivative of betulinic acid protects human Retinal Pigment Epithelial (RPE) cells from cobalt chloride-induced acute hypoxic stress. Experimental Eye Research, 180, 92-101. [More Information]
Lukowski, S., Lo, C., Sharov, A., Nguyen, Q., Fang, L., Hung, S., Zhu, L., Zhang, T., Grunert, U., Nguyen, T., Gillies, M., et al (2019). A single-cell transcriptome atlas of the adult human retina. EMBO Journal, 38(18), 1-15. [More Information]
Cheng, Z., Zhang, T., Zheng, J., Ding, W., Wang, Y., Li, Y., Zhu, L., Murray, M., Zhou, F. (2019). Betulinic acid derivatives can protect human Muller cells from glutamate-induced oxidative stress. Experimental Cell Research, 383(1), 1-8. [More Information]
Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Zhu, L., Fraser, C., Graham, S., Klistorner, A., et al (2019). Differing Structural and Functional Patterns of Optic Nerve Damage in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder. Ophthalmology, 126(3), 445-453. [More Information]
Bahrami, B., Shen, W., Zhu, L., Zhang, T., Chang, A., Gillies, M. (2019). Effects of VEGF inhibitors on human retinal pigment epithelium under high glucose and hypoxia. Clinical and Experimental Ophthalmology, 47(8), 1074-1081. [More Information]
You, Y., Zhu, L., Zhang, T., Shen, T., Fontes, A., Yiannikas, C., Parratt, J., Barton, J., Schulz, A., Gupta, V., Barnett, M., Fraser, C., Gillies, M., Graham, S., Klistorner, A. (2019). Evidence of Muller Glial Dysfunction in Patients with Aquaporin-4 Immunoglobulin G-Positive Neuromyelitis Optica Spectrum Disorder. Ophthalmology, 126(6), 801-810. [More Information]
Zhang, T., Zhu, L., Madigan, M., Liu, W., Shen, W., Cherepanoff, S., Zhou, F., Zeng, S., Du, J., Gillies, M. (2019). Human macular Muller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery. eLife, 8, 1-19. [More Information]
Zhang, T., Gillies, M., Wang, Y., Shen, W., Bahrami, B., Zeng, S., Zhu, M., Yao, W., Zhou, F., Murray, M., Zhu, L., et al (2019). Simvastatin Protects Photoreceptors from all-trans-retinal Induced Oxidative Stress with Up-regulation of Interphotoreceptor Retinoid Binding Protein. British Journal of Pharmacology, 176(12), 2063-2078. [More Information]

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2018

Shen, W., Lee, S., Yam, M., Zhu, L., Zhang, T., Pye, V., Mathai, A., Shibagaki, K., Zhang, J., Matsugi, T., Gillies, M. (2018). A Combination Therapy Targeting Endoglin and VEGF-A Prevents Subretinal Fibro-Neovascularization Caused by Induced Muller Cell Disruption. Investigative Ophthalmology and Visual Science, 59(15), 6075-6088. [More Information]
Zhu, L., Shen, W., Zhang, T., Wang, Y., Bahrami, B., Zhou, F., Gillies, M. (2018). Characterization of canonical Wnt signalling changes after induced disruption of Muller cell in murine retina. Experimental Eye Research, 175, 173-180. [More Information]
Wang, K., Zhu, X., Yao, Y., Yang, M., Zhou, F., Zhu, L. (2018). Corosolic acid induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells via disruption of MELK-FoxM1 signaling. Oncology Reports, 39(6), 2777-2786. [More Information]
Zhang, T., Gillies, M., Madigan, M., Shen, W., Du, J., Grunert, U., Zhou, F., Yam, M., Zhu, L. (2018). Disruption of De Novo Serine Synthesis in MÃ¼ller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage. Molecular Neurobiology, 55(8), 7025-7037. [More Information]
Zhang, T., Bahrami, B., Zhu, L. (2018). Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina. In Alexzander A. A. Asea, Punit Kaur (Eds.), HSP70 in human diseases and disorders, (pp. 273-287). Cham: Springer. [More Information]
Zhu, X., Wang, K., Zhou, F., Zhu, L. (2018). Paeoniflorin attenuates atRAL-induced oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca2+/CaMKII-dependent activation of AMPK. Archives of Pharmacal Research, 41(10), 1009-1018. [More Information]
Zhu, X., Wang, K., Zhang, K., Pan, Y., Zhou, F., Zhu, L. (2018). Polyphyllin i induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells through targeting p53. Anti-Cancer Agents in Medicinal Chemistry, 18(6), 875-881. [More Information]
Lu, X., Chan, T., Cheng, Z., Shams, T., Zhu, L., Murray, M., Zhou, F. (2018). The 5'-AMP-activated protein kinase (AMPK) regulates the function and expression of human Organic Anion Transporting Polypeptide 1A2. Molecular Pharmacology, 94(6), 1412-1420. [More Information]
Zhou, F., Zhu, L., Zhu, X., Xue, L., Yao, Y., Wang, K., Tan, C., Zhuang, M. (2018). The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells. Acta Biochimica et Biophysica Sinica, 50(9), 914-920. [More Information]
Lu, X., Chan, T., Zhu, L., Bao, X., Velkov, T., Zhou, Q., Li, J., Chan, H., Zhou, F. (2018). The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models. European Journal of Pharmaceutical Sciences, 115, 132-143. [More Information]
Shams, T., Lu, X., Zhu, L., Zhou, F. (2018). The inhibitory effects of five alkaloids on the substrate transport mediated through human organic anion and cation transporters. Xenobiotica, 48(2), 197-205. [More Information]
Zhu, X., Wang, K., Yao, Y., Zhang, K., Zhou, F., Zhu, L. (2018). Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis. Journal of Biochemical and Molecular Toxicology, 32(1), 1-7. [More Information]

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2017

Wang, K., Yao, Y., Zhu, X., Zhang, K., Zhou, F., Zhu, L. (2017). Amyloid B induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production. Journal of Biochemical and Molecular Toxicology, 31(6), 1-5. [More Information]
Shen, W., Yau, B., Lee, S., Zhu, L., Yam, M., Gillies, M. (2017). Effects of Ranibizumab and Aflibercept on Human Muller Cells and Photoreceptors under Stress Conditions. International Journal of Molecular Sciences, 18(3), 1-16. [More Information]
Wang, K., Zhu, X., Zhang, K., Zhou, F., Zhu, L. (2017). Neuroprotective effect of tetramethylpyrazine against all-trans-retinal toxicity in the differentiated Y-79 cells via upregulation of IRBP expression. Experimental Cell Research, 359(1), 120-128. [More Information]
Wang, K., Zhu, X., Zhang, K., Yao, Y., Zhuang, M., Tan, C., Zhou, F., Zhu, L. (2017). Puerarin inhibits amyloid (beta)-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. Experimental Cell Research, 357(2), 335-340. [More Information]
Zhou, F., Zhu, L., Wang, K., Murray, M. (2017). Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition. Advanced Drug Delivery Reviews, 116, 21-36. [More Information]

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2016

Chan, T., Cheung, F., Zheng, J., Lu, X., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2016). Casein Kinase 2 Is a Novel Regulator of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Trafficking. Molecular Pharmaceutics, 13(1), 144-154. [More Information]
Xu, C., Zhu, L., Chan, T., Lu, X., Shen, W., Madigan, M., Gillies, M., Zhou, F. (2016). Chloroquine and Hydroxychloroquine Are Novel Inhibitors of Human Organic Anion Transporting Polypeptide 1A2. Journal of Pharmaceutical Sciences, 105(2), 884-890. [More Information]
Wang, K., Zhu, X., Zhang, K., Zhu, L., Zhou, F. (2016). FoxM1 inhibition enhances chemosensitivity of docetaxel-resistant A549 cells to docetaxel via activation of JNK/mitochondrial pathway. Acta Biochimica et Biophysica Sinica, 48(9), 804-809. [More Information]
Zhu, X., Wang, K., Zhang, K., Xu, F., Yin, Y., Zhu, L., Zhou, F. (2016). Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression. Acta Biochimica et Biophysica Sinica, 48(5), 462-467. [More Information]
Wang, K., Zhu, X., Zhang, K., Zhou, F., Zhu, L. (2016). Gas1 Knockdown Increases the Neuroprotective Effect of Glial Cell-Derived Neurotrophic Factor Against Glutamate-Induced Cell Injury in Human SH-SY5Y Neuroblastoma Cells. Cellular and Molecular Neurobiology, 36(4), 603-611. [More Information]
Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, H., Li, J., Zhou, F. (2016). Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins. Journal of Antimicrobial Chemotherapy, 71(2), 403-412. [More Information]
Zhu, X., Wang, K., Zhang, K., Zhou, F., Zhu, L. (2016). Induction of oxidative and nitrosative stresses in human retinal pigment epithelial cells by all-trans-retinal. Experimental Cell Research, 348(4), 87-94. [More Information]
Wang, K., Zhu, X., Zhang, K., Wu, Z., Sun, S., Zhou, F., Zhu, L. (2016). Neuroprotective effect of Puerarin on glutamate-induced cytotoxicity in differentiated Y-79 cells via inhibition of ROS generation and Ca2+ influx. International Journal of Molecular Sciences, 17(7), 1-13. [More Information]
Zhu, X., Wang, K., Zhang, K., Lin, X., Zhu, L., Zhou, F. (2016). Puerarin Protects Human Neuroblastoma SH-SY5Y Cells against Glutamate-Induced Oxidative Stress and Mitochondrial Dysfunction. Journal of Biochemical and Molecular Toxicology, 30(1), 22-28. [More Information]
Zheng, J., Chan, T., Zhu, L., Yan, X., Cao, Z., Wang, Y., Zhou, F. (2016). The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs). Xenobiotica, 46(9), 831-840. [More Information]
Chan, T., Lu, X., Shams, T., Zhu, L., Murray, M., Zhou, F. (2016). The Role of N-Glycosylation in Maintaining the Transporter Activity and Expression of Human Oligopeptide Transporter 1. Molecular Pharmaceutics, 13(10), 3449-3456. [More Information]

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2015

Wang, K., Xie, M., Zhu, L., Zhu, X., Zhang, K., Zhou, F. (2015). Ciliary neurotrophic factor protects SH-SY5Y neuroblastoma cells against A-Beta1-42-induced neurotoxicity via activating the JAK2/STAT3 axis. Folia Neuropathologica, 53(3), 226-235. [More Information]
Coorey, N., Shen, W., Zhu, L., Gillies, M. (2015). Differential Expression of IL-6/gp130 Cytokines, Jak-STAT Signalling and Neuroprotection After Muller Cell Ablation in a Transgenic Mouse Model. Investigative Ophthalmology and Visual Science, 56(4), 2151-2161. [More Information]
Zhu, L., Shen, W., Lyons, B., Wang, Y., Zhou, F., Gillies, M. (2015). Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Muller cell disruption. Journal of Neurochemistry, 133(6), 909-918. [More Information]
Zhu, X., Liu, A., Zhang, K., Wang, K., Gao, Y., Zhou, F., Zhu, L. (2015). High-yield soluble expression of recombinant human interleukin-1Î² in Escherichia coli. Romanian Biotechnology Letters, 20(1), 10114-10122.
Chan, T., Zhu, L., Madigan, M., Wang, K., Shen, W., Gillies, M., Zhou, F. (2015). Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells. British Journal of Pharmacology, 172(9), 2343-2353. [More Information]
Chung, S., Gillies, M., Sugiyama, Y., Zhu, L., Lee, S., Shen, W. (2015). Profiling of MicroRNAs Involved in Retinal Degeneration Caused by Selective MÃ¼ller Cell Ablation. PloS One, 10(3), 1-18. [More Information]
Chan, T., Zheng, J., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2015). Putative Transmembrane Domain 6 of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Influences Transporter Substrate Binding, Protein Trafficking, and Quality Control. Molecular Pharmaceutics, 12(1), 111-119. [More Information]
Zhu, X., Wang, K., Zhang, K., Tan, X., Wu, Z., Sun, S., Zhou, F., Zhu, L. (2015). Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1B-Induced Nitrative/Oxidative Stress. International Journal of Molecular Sciences, 16(9), 21775-21790. [More Information]
Xu, C., Zhu, L., Chan, T., Lu, X., Shen, W., Gillies, M., Zhou, F. (2015). The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice. PloS One, 10(3), 1-14. [More Information]

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2014

Tan, X., Sun, S., Liu, Y., Zhu, T., Wang, K., Ren, T., Wu, Z., Xu, H., Zhu, L. (2014). Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome. Eye, 28(5), 608-613. [More Information]
Barthelmes, D., Zhu, L., Shen, W., Gillies, M., Irhimeh, M. (2014). Differential gene expression in Lin-/VEGF-R2+ bone marrow-derived endothelial progenitor cells isolated from diabetic mice. Cardiovascular Diabetology, 13(1), 1-10. [More Information]
Shen, W., Lee, S., Araujo, J., Chung, S., Zhu, L., Gillies, M. (2014). Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Muller cell ablation. GLIA, 62(7), 1110-1124. [More Information]
Wang, K., Zhou, F., Zhu, L., Zhu, X., Zhang, K., Zhu, L. (2014). High level soluble expression, purification, and characterization of human ciliary neruonotrophic factor in Escherichia coli by single protein production system. Protein Expression and Purification, 96, 8-13. [More Information]
Li, Z., Cheung, F., Zheng, J., Chan, T., Zhu, L., Zhou, F. (2014). Interaction of the Bioactive Flavonol, Icariin, with the Essential Human Solute Carrier Transporters. Journal of Biochemical and Molecular Toxicology, 28(2), 91-97. [More Information]
Li, Z., Wang, K., Zheng, J., Cheung, F., Chan, T., Zhu, L., Zhou, F. (2014). Interactions of the active components of Punica granatum (pomegranate) with the essential renal and hepatic human Solute Carrier transporters. Pharmaceutical Biology, 52(12), 1510-1517. [More Information]
Wang, K., Zhu, X., Zhang, K., Zhu, L., Zhou, F. (2014). Investigation of gallic acid induced anticancer effect in human breast carcinoma MCF-7 cells. Journal of Biochemical and Molecular Toxicology, 28(9), 387-393. [More Information]
Wang, K., Zhou, F., Zhu, X., Zhang, K., Huang, B., Zhu, L., Zhu, L. (2014). Neuroprotective properties of ciliary neurotrophic factor on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells. Folia Neuropathologica, 52(2), 121-127. [More Information]
Zheng, J., Chan, T., Cheung, F., Zhu, L., Murray, M., Zhou, F. (2014). PDZK1 and NHERF1 Regulate the Function of Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) by Modulating Its Subcellular Trafficking and Stability. PloS One, 9(4), 1-11. [More Information]
Wang, K., Zhu, L., Zhu, X., Zhang, K., Huang, B., Zhang, J., Zhang, Y., Zhu, L., Zhou, B., Zhou, F. (2014). Protective Effect of Paeoniflorin on AB 25-35- Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction. Cellular and Molecular Neurobiology, 34(2), 227-234. [More Information]
Zhu, X., Xie, M., Wang, K., Zhang, K., Gao, Y., Zhu, L., Zhou, F. (2014). The effect of puerarin against IL-1B-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). Molecular Vision, 20, 1815-1823.
Wang, K., Zhang, K., Lv, Z., Zhu, X., Zhu, L., Zhou, F. (2014). Ultrasensitive detection of microRNA with isothermal amplification and a time-resolved fluorescence sensor. Biosensors and Bioelectronics, 57, 91-95. [More Information]
Zhu, X., Wang, K., Zhang, K., Zhu, L., Zhou, F. (2014). Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicology Letters, 227(1), 65-73. [More Information]

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2013

Zhu, L., Shen, W., Zhu, M., Coorey, N., Nguyen, A., Barthelmes, D., Gillies, M. (2013). Anti-Retinal Antibodies in Patients With Macular Telangiectasia Type 2. Investigative Ophthalmology and Visual Science, 54(8), 5675-5683. [More Information]
Barthelmes, D., Irhimeh, M., Gillies, M., Karimipour, M., Zhou, M., Zhu, L., Shen, W. (2013). Diabetes impairs mobilization of mouse bone marrow-derived Lin-/VEGF-R2+ progenitor cells. Blood Cells, Molecules and Diseases, 51(3), 163-173. [More Information]
Zhou, F., Zheng, J., Zhu, L., Jodal, A., Cui, P., Wong, K., Gurney, H., Church, W., Murray, M. (2013). Functional Analysis of Novel Polymorphisms in the Human SLCO1A2 Gene that Encodes the Transporter OATP1A2. The AAPS Journal, 15(4), 1099-1108. [More Information]
Chan, T., Li, Z., Zheng, J., Cheung, F., Zhu, L., Zhou, F. (2013). Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters. World Journal of Pharmacology, 2(4), 115-121. [More Information]
Shen, W., Zhu, L., Lee, S., Chung, S., Gillies, M. (2013). Involvement of NT3 and P75NTR in photoreceptor degeneration following selective Muller cell ablation. Journal of Neuroinflammation, 10(137), 1-13. [More Information]
Barthelmes, D., Irhimeh, M., Gillies, M., Zhu, L., Shen, W. (2013). Isolation and characterization of mouse bone marrow-derived Lin-/VEGF-R2+ progenitor cells. Annals of Hematology, 92(11), 1461-1472. [More Information]
Xu, F., Li, Z., Zheng, J., Cheung, F., Chan, T., Zhu, L., Zhuge, H., Zhou, F. (2013). The Inhibitory Effects of the Bioactive Components Isolated from Scutellaria Baicalensis on the Cellular Uptake Mediated by the Essential Solute Carrier Transporters. Journal of Pharmaceutical Sciences, 102(11), 4205-4211. [More Information]

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2012

Shen, W., Fruttiger, M., Zhu, L., Chung, S., Barnett, N., Kirk, J., Lee, S., Coorey, N., Killingsworth, M., Sherman, L., Gillies, M. (2012). Conditional Muller Cell Ablation Causes Independent Neuronal and Vascular Pathologies in a Novel Transgenic Model. Journal of Neuroscience, 32(45), 15715-15727. [More Information]
Zhou, F., Li, Z., Lam, P., Zhu, L., Wang, K. (2012). Current Updates in the Genetic Polymorphisms of Human Organic Anion Transporters (OATs). Journal of Pharmacogenomics & Pharmacoproteomics, 3(6), 1-8. [More Information]
Len, A., Powner, M., Zhu, L., Hageman, G., Song, X., Fruttiger, M., Gillies, M. (2012). Pilot Application of iTRAQ to the Retinal Disease Macular Telangiectasia. Journal of Proteome Research, 11(2), 537-553. [More Information]
Coorey, N., Shen, W., Chung, S., Zhu, L., Gillies, M. (2012). The role of glia in retinal vascular disease. Clinical and Experimental Optometry, 95(3), 266-281. [More Information]

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2011

Irhimeh, M., Shen, W., Chung, S., Zhu, L., Barthelmes, D., Gillies, M. (2011). Erythropoetin treatment recruits pECFCs from the marrow into the blood and stabilizes retinal vasculature. Experimental Hematology, 39(8), S77-S78.
Zhou, F., Lee, A., Krafczyk, K., Zhu, L., Murray, M. (2011). Protein Kinase C Regulates the Internalization and Function of the Human Organic Anion Transporting Polypeptide 1A2. British Journal of Pharmacology, 162(6), 1380-1388. [More Information]
Shen, W., Li, S., Chung, S., Zhu, L., Stayt, J., Su, T., Couraud, P., Romero, I., Weksler, B., Gillies, M. (2011). Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-Î²1-induced permeability of centrally derived vascular endothelium. European Journal of Cell Biology, 90(4), 323-332. [More Information]

2010

Zhou, F., Zhu, L., Cui, P., Church, W., Murray, M. (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). British Journal of Pharmacology, 159, 419-427. [More Information]

Selected Grants

2023

Rewarding Research 2024, Zhu L, Faculty of Medicine and Health/FMH Rewarding Research Success
Targeting the glucose-alanine cycle to treat retinal diseases, Zhang B, Gillies M, Zhu L, Australian Vision Research (AVR)/Australian Vision Research Grants

2022

Targeting Nrf2-MAFF pathway in Mller cells to treat macula degeneration, Zhu L, Gilles M, Zhang T, Ophthalmic Research Institute of Australia (ORIA)/ORIA Grant

2019

Targeting a novel pathogenic glia-neuronal pathway in retinal diseases, Gillies M, Zhu L, Fan X, Zhang T, Fernando N, Zhou F, National Health and Medical Research Council (NHMRC)/Ideas Grant
CYP4V2-associated Bietti's crystalline dystrophy , Zhu L, Sun X, Office of Global Engagement/Travel Grants
Novel approaches to advance the research on human macular degeneration, Zhu L, Fan X, Gillies M, Zhou F, Zhang T, Cheng Z, Office of Global Engagement/Partnership Collaboration Awards

2017

Targeting the de novo serine synthesis pathway in macular disease, Gillies M, Zhu L, Shen W, Du J, National Health and Medical Research Council (NHMRC)/Project Grants

2015

Molecular investigation of the neuroprotective effect of simvastatin on photoreceptors, Zhu L, University of Sydney/Kickstart Grants Program

2014

Comparison of MÃ¼ller cells isolated from the human macula and peripheral retina, Gillies M, Zhu L, Ophthalmic Research Institute of Australia (ORIA)/Research Grant
NGC QUEST 10 plus Chromatography System , Gillies M, Shen W, Zhu L, McAvoy J, DVC Research/Equipment Grant

2013

CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility, Allbutt H, Ammit A, Assinder S, Bao B, Barrs V, Black J, Brennan-Speranza T, Buckland M, Burgess J, Byrne M, Camp A, Christopherson R, Codd R, Day M, de Graaf S, Dixon K, Dong Q, Dos Remedios C, Fraser S, Fu D, Goldsbury C, Groundwater P, Halliday G, Hambly B, Hardikar A, Hibbs D, Ho P, Hong A, Huang M, Huq F, Jansson P, Johnstone D, Joshua D, Ju Y, Kalinowski D, King N, Kovacevic Z, Kril J, Lai D, Lane D, Lay P, Lee C, Lok H, Lovicu F, Lu Z, Lyons J, Mason R, McLennan S, Morris B, Murphy C, Murray M, Naylor M, Oliver B, Owens T, Poronnik P, Rendina L, Richardson D, Ryan R, Sahni S, Scolyer R, Shafie N, Sharland A, Slobedman B, Sunde M, Sutherland G, Triccas J, Williamson P, Zhu L, Zreiqat H, National Health and Medical Research Council (NHMRC)/Equipment Grant

2012

The contribution of aberrant Wnt signalling to neuronal and vascular pathology in retinal disease, Gillies M, Shen W, McAvoy J, Zhu L, National Health and Medical Research Council (NHMRC)/Project Grants
QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility, Ammit A, Bagley E, Bao B, Boyer M, Byrne M, Camp A, Day M, Dong Q, Dos Remedios C, Fraser S, Fu D, Hanrahan J, Hibbs D, Huang M, Jansson P, Ju Y, Kovacevic Z, Kril J, Lai D, Lane D, Lay P, Lyons J, Morris B, Murphy C, Rendina L, Richardson D, Sutherland G, Vandenberg R, Whittington R, Zhang D, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B, National Health and Medical Research Council (NHMRC)/Equipment Grant

2011

Neuroprotection and anti-angiogenic therapy using a novel transgenic model, Shen W, Zhu L, Ophthalmic Research Institute of Australia (ORIA)/Research Grant

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