Professor Luigi Fontana

MD, PhD
Professor of Medicine and Nutrition
Leonard P. Ullman Chair in Translational Metabolic Health
Director of the Healthy Longevity Research and Clinical Program

Member of the Charles Perkins Centre

Telephone +61 2 8627 7499

Website Charles Perkins Centre

Map

Research interests

Professor Fontana is interested in preventive medicine and in the mechanisms mediating healthy longevity in humans. He is focused primarily on the role of nutrition, physical exercise and CR mimetics in retarding the aging process and in preventing age-associated chronic disease. In particular, he is applying whole-body physiological and tissue-specific molecular approaches to investigate the effects of several clinical interventions, including calorie restriction, intermittent fasting, protein restriction, phytochemical-rich plant-based diets, physical exercise and CR mimetics, on outcomes such as cardiovascular function, glucose metabolism, inflammation, neuroendocrine and immune function, gut microbiome and cancer biology. He is also interested in the endocrine role of abdominal fat storage as a mediator of insulin resistance and accelerated aging.

Associations

  • Scientific Member of the Board of Directors, American Aging Association
  • Fellow, Centre for Economic and International Studies, University of Rome "Tor Vergata", Italy
  • Scholar, Institute of Public Health, Washington University in St.Louis, USA

Awards and honours

  • 2016 Vincent Cristofalo AFAR Aging Award, American Federation of Aging Research (AFAR)
  • 2011 Glenn Award for Research in Biological Mechanisms of Aging, Glenn Foundation for Aging Research
  • 2009 Glenn/AFAR Breakthroughs in Gerontology Award, American Federation of Aging Research
  • 2004 Washington University Clinical Nutrition Research Unit Center P&F Award, Washington University in St.Louis, USA
  • 1994 “Summa cum laude” Graduate (M.D.), University of Verona, Italy

In the media

MAJOR MEDIA MENTIONS (selected)

  • The New York Times- “Food for Holiday Thought: Eat Less, Live to 140?” by David Hochman, Nov 23, 2003
  • Science- “Lean, Hungry, and Healthy” (Science 2004;304:514)
  • Featured in "Challenge the aging: You can live longer", a television documentary produced by the Japanese Nippon Hoso Kyokai (NHK) Television, Sep 19 2004
  • New Scientist- “Eat less and keep disease at bay” (New Scientist 2004;182:2444)
  • Los Angeles Times, CA, USA - “The raw food puzzle”, by Emily Singer, April 4, 2005.
  • Featured in "Secrets of Living, Aging, Illness and Death", a television documentary produced by the South Korea’s premier public broadcaster KBS-TV, Oct, 2005
  • Featured in "Nutrition and aging", a television documentary produced by the Italian premier public broadcaster RAI-UNO, Sep 1, 2005
  • Los Angeles Times, CA, USA - “Can we live longer?” by Andreas von Bubnoff, Dec 25, 2006
  • The Scientist- “The Trouble with Markers” (The Scientist 2006;20(3):36)
  • The Wall Street Journal- “Reducing Your Daily Calories by 40%: The Science Behind 'Starvation' Diets”, by Tara Parker-Pope, Jan 31, 2006.
  • The Times, London, UK - “Eat less — and live to 130” by David Mattin, Oct 3, 2005
  • The Washington Post, USA - “Low-Calorie Diet Keeps Heart Young”, Jan 13, 2006
  • Featured in scientific radio program “The Health Report” by Norman Swan for the Australian Broadcasting Network. Interview topic: “The role of caloric restrictions in the ageing of the heart”, on air Jan 23 2006.
  • Featured in a Special TV Report of CNN "Subtract calories, add years” by Keith Oppenheim, Jun 31, 2006
  • Featured in scientific radio program “The Health Report” by Dr. Barry Dworkin for the Canadian Broadcasting Network. Interview topic: “Caloric restrictions in the aging of the heart”, on air Feb 5, 2006.
  • The Washington Post, USA - “High Protein Diets May Boost Cancer Risk” by Steven Reinberg, Dec 7, 2006
  • The Financial Times, UK - “Pear shapes more healthy than apples”, by Alan Cane, Mar 17, 2007
  • Featured in " Live longer: Caloric restrictions and ageing", a television documentary produced by the UK’s premier public broadcaster BBC4, Feb 21, 2007
  • Newsweek Magazine- “The Search for Longer Life”, by Anne Underwood, Dec 12, 2008.
  • Featured in "Dieta Mediterrânea", a television documentary produced by the Brasilian Globo TV, Dec 12, 2008
  • Los Angeles Times, CA, USA - “Running on empty: the pros and cons of fasting” by Shari Roan, Feb 2, 2009
  • The New York Times, USA- “The Calorie-Restriction Experiment” by Jon Gertner, Oct 7, 2009.
  • Featured in scientific radio program “On Point” with Tom Ashbrook for the National Public Radio (NPR), USA. Interview topic: “The Future of Aging”. Live on Nov 5, 2009
  • Time Magazine- “Health Checkup: How to Live 100 Years - Eat Less, Live Longer?”, by Bryan Walsh, Feb 11, 2010.
  • Featured in scientific radio program “Quirks & Quarks” for the CBC Radio, Canada. Interview topic: “Hungry for Life”, on air Apr 24, 2010.
  • New Scientist- “Eat less, live longer?” (New Scientist 2010;2762:36-39)
  • Scientific American- “Defective Growth Gene in Rare Dwarfism Disorder Stunts Cancer and Diabetes” by Nina Bai, Feb 17, 2011
  • Featured in radio program “Patt Morrison Show” for the National Public Radio, USA. Interview topic: “Keys to Longevity”, on air May 2, 2011.
  • Nature- “Live long and prosper” (Nature 2012;492:S18-20)
  • New Scientist- “Deprive yourself: The real benefits of fasting” (New Scientist 2012;2891:46-49)
  • Featured in "Eat, Fast and Live Longer", a “Horizon” television documentary produced by the UK’s premier public broadcaster BBC, which has been aired in UK, USA, Europe and Australia in 2012
  • Time Magazine- “You Asked: Should I Try a Fasting Diet?”, by Markham Heid, Mar 30, 2016.
  • Time Magazine- “9 Healthy Snacks That Prevent Overeating”, by Markham Heid, Aug 11, 2016.

Selected grants

2018

  • Luigi Fontana - SRRRP (DVCR-419); Fontana L; DVC Research/Strategic Research Recruitment and Retention Program (SRRRP).

Selected publications

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Book Chapters

  • Weiss, E., Fontana, L. (2014). Metabolic consequences of calorie restriction. In A. Catharine Ross (Eds.), Modern Nutrition in Health and Disease: Eleventh Edition, (pp. 678-683). Philadelphia: Wolters Kluwer Health Adis.

Journals

  • Contreras, N., Fontana, L., Tosti, V., Nikolich-Zugich, J. (2018). Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution. GeroScience, 40(3), 279-291. [More Information]
  • Veronese, N., Solmi, M., Caruso, M., Giannelli, G., Osella, A., Evangelou, E., Maggi, S., Fontana, L., Stubbs, B., Tzoulaki, I. (2018). Dietary fiber and health outcomes: An umbrella review of systematic reviews and meta-analyses. American Journal of Clinical Nutrition, 107(3), 436-444. [More Information]
  • Il'yasova, D., Fontana, L., Bhapkar, M., Pieper, C., Spasojevic, I., Redman, L., Das, S., Huffman, K., Kraus, W. (2018). Effects of 2�years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial. Aging Cell, 17(2), 1-9. [More Information]
  • Tosti, V., Bertozzi, B., Fontana, L. (2018). Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(3), 318-326. [More Information]
  • Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L., Phillips, D., Weinstock, G., Fontana, L., Cross, A., et al (2018). Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota. Cell Metabolism, 27(6), 1222-1235. [More Information]
  • Fontana, L. (2018). Interventions to promote cardiometabolic health and slow cardiovascular ageing. Nature Reviews Cardiology, 15(9), 566-577. [More Information]
  • Pili, R., Fontana, L. (2018). Low-protein diet in cancer: Ready for prime time? Nature Reviews Endocrinology, 14(7), 384-386. [More Information]
  • Fontana, L., Mitchell, S., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D., Maissan, P., Speakman, J., et al (2018). The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon. Aging Cell, 17(3). [More Information]
  • Veronese, N., Stubbs, B., Fontana, L., Trevisan, C., Bolzetta, F., De Rui, M., Sartori, L., Musacchio, E., Zambon, S., Maggi, S., et al (2017). A comparison of objective physical performance tests and future mortality in the elderly people. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(3), 362-368. [More Information]
  • Das, S., Roberts, S., Bhapkar, M., Villareal, D., Fontana, L., Martin, C., Racette, S., Fuss, P., Kraus, W., et al (2017). Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: A 2-y randomized controlled trial of calorie restriction in nonobese humans. American Journal of Clinical Nutrition, 105(4), 913-927. [More Information]
  • Most, J., Tosti, V., Redman, L., Fontana, L. (2017). Calorie restriction in humans: An update. Ageing Research Reviews, 39, 36-45. [More Information]
  • Simpson, S., Le Couteur, D., Raubenheimer, D., Solon-Biet, S., Cooney, G., Cogger, V., Fontana, L. (2017). Dietary protein, aging and nutritional geometry. Ageing Research Reviews, 39, 78-86. [More Information]
  • Racette, S., Rochon, J., Uhrich, M., Villareal, D., Das, S., Fontana, L., Bhapkar, M., Martin, C., Redman, L., Fuss, P., et al (2017). Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Medicine and Science in Sports and Exercise, 49(11), 2240-2249. [More Information]
  • Veronese, N., Stubbs, B., Noale, M., Solmi, M., Vaona, A., Demurtas, J., Nicetto, D., Crepaldi, G., Schofield, P., Koyanagi, A., et al (2017). Fried potato consumption is associated with elevated mortality: An 8-y longitudinal cohort study. American Journal of Clinical Nutrition, 106(1), 162-167. [More Information]
  • Eitan, E., Tosti, V., Suire, C., Cava, E., Berkowitz, S., Bertozzi, B., Raefsky, S., Veronese, N., Spangler, R., Spelta, F., et al (2017). In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles. Aging Cell, 16(6), 1430-1433. [More Information]
  • Magni, P., Bier, D., Pecorelli, S., Agostoni, C., Astrup, A., Brighenti, F., Cook, R., Folco, E., Fontana, L., Gibson, R., et al (2017). Perspective: Improving nutritional guidelines for sustainable health policies: Current status and perspectives. Advances in Nutrition, 8(4), 532-545. [More Information]
  • Griffin, N., Ahern, P., Cheng, J., Heath, A., Ilkayeva, O., Newgard, C., Fontana, L., Gordon, J. (2017). Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. Cell Host and Microbe, 21(1), 84-96. [More Information]
  • Ruggenenti, P., Abbate, M., Ruggiero, B., Rota, S., Trillini, M., Aparicio, C., Parvanova, A., Iliev, I., Pisanu, G., Fontana, L., et al (2017). Renal and systemic effects of calorie restriction in patients with type 2 diabetes with abdominal obesity: A randomized controlled trial. Diabetes, 66(1), 75-86. [More Information]
  • Veronese, N., Cereda, E., Stubbs, B., Solmi, M., Luchini, C., Manzato, E., Sergi, G., Manu, P., Harris, T., Fontana, L., et al (2017). Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis. Ageing Research Reviews, 35, 63-73. [More Information]
  • Lamming, D., Baar, E., Arriola Apelo, S., Tosti, V., Fontana, L. (2017). Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice. Nutrition and Healthy Aging, 4(3), 239-245. [More Information]
  • Veronese, N., Facchini, S., Stubbs, B., Luchini, C., Solmi, M., Manzato, E., Sergi, G., Maggi, S., Cosco, T., Fontana, L. (2017). Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 72, 87-94. [More Information]
  • Bertozzi, B., Tosti, V., Fontana, L. (2016). Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being. Gerontology, 63(1), 13-19. [More Information]
  • Veronese, N., Li, Y., Manson, J., Willett, W., Fontana, L., Hu, F. (2016). Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: Prospective cohort study. BMJ, 355, 1-7. [More Information]
  • Fontana, L., Cummings, N., Arriola Apelo, S., Neuman, J., Kasza, I., Schmidt, B., Cava, E., Spelta, F., Tosti, V., et al (2016). Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health. Cell Reports, 16(2), 520-530. [More Information]
  • Villareal, D., Fontana, L., Das, S., Redman, L., Smith, S., Saltz�man, E., Bales, C., Rochon, J., Pieper, C., Huang, M., et al (2016). Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. Journal of Bone and Mineral Research, 31(1), 40-51. [More Information]
  • Fontana, L., Villareal, D., Das, S., Smith, S., Meydani, S., Pittas, A., Klein, S., Bhapkar, M., Rochon, J., Ravussin, E., et al (2016). Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: A randomized clinical trial. Aging Cell, 15(1), 22-27. [More Information]
  • Veronese, N., Stubbs, B., Fontana, L., Trevisan, C., Bolzetta, F., De Rui, M., Sartori, L., Musacchio, E., Zambon, S., Maggi, S., et al (2016). Frailty Is Associated with an Increased Risk of Incident Type 2 Diabetes in the Elderly. Journal of the American Medical Directors Association (JAMDA), 17(10), 902-907. [More Information]
  • Yang, L., Licastro, D., Cava, E., Veronese, N., Spelta, F., Rizza, W., Bertozzi, B., Villareal, D., Fontana, L., et al (2016). Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle. Cell Reports, 14(3), 422-428. [More Information]
  • Meydani, S., Das, S., Pieper, C., Lewis, M., Klein, S., Dixit, V., Gupta, A., Villareal, D., Bhapkar, M., Fontana, L., et al (2016). Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: A randomized controlled trial in non-obese humans. Aging, 8(7), 1416-1431. [More Information]
  • Nikolich-Zugich, J., Goldman, D., Cohen, P., Cortese, D., Fontana, L., Kennedy, B., Mohler, M., Olshansky, S., Perls, T., Perry, D., et al (2016). Preparing for an aging world: Engaging biogerontologists, geriatricians, and the society. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(4), 435-444. [More Information]
  • Ravussin, E., Redman, L., Rochon, J., Das, S., Fontana, L., Kraus, W., Romashkan, S., Williamson, D., Meydani, S., Villareal, D., et al (2015). A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70(9), 1097-1104. [More Information]
  • Atella, V., Kopinska, J., Medea, G., Belotti, F., Tosti, V., Mortari, A., Cricelli, C., Fontana, L. (2015). Excess body weight increases the burden of age-associated chronic diseases and their associated health care expenditures. Aging, 7(10), 882-892.
  • Omodei, D., Pucino, V., Labruna, G., Procaccini, C., Galgani, M., Perna, F., Pirozzi, D., De Caprio, C., Marone, G., Fontana, L., et al (2015). Immune-metabolic profiling of anorexic patients reveals an anti-oxidant and anti-inflammatory phenotype. Metabolism: Clinical and Experimental, 64(3), 396-405. [More Information]
  • Longo, V., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H., Caruso, C., Curiel, T., de Cabo, R., Fontana, L., et al (2015). Interventions to slow aging in humans: Are we ready? Aging Cell, 14(4), 497-510. [More Information]
  • Sergi, G., Veronese, N., Fontana, L., De Rui, M., Bolzetta, F., Zambon, S., Corti, M., Baggio, G., Toffanello, E., et al (2015). Pre-frailty and risk of cardiovascular disease in elderly men and women: The Pro.V.A. Study. Journal of the American College of Cardiology, 65(10), 976-983. [More Information]
  • Fontana, L., Partridge, L. (2015). Promoting health and longevity through diet: From model organisms to humans. Cell, 161(1), 106-118. [More Information]
  • Dey, N., Wagner, V., Blanton, L., Cheng, J., Fontana, L., Haque, R., Ahmed, T., Gordon, J. (2015). Regulators of Gut Motility Revealed by a Gnotobiotic Model of Diet-Microbiome Interactions Related to Travel. Cell, 163(1), 95-107. [More Information]
  • Lamming, D., Cummings, N., Rastelli, A., Gao, F., Cava, E., Bertozzi, B., Spelta, F., Pili, R., Fontana, L. (2015). Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model. Oncotarget, 6(31), 31233-31240. [More Information]
  • Redman, L., Kraus, W., Bhapkar, M., Das, S., Racette, S., Martin, C., Fontana, L., Wong, W., Roberts, S., Ravussin, E. (2014). Energy requirements in nonobese men and women: Results from CALERIE. American Journal of Clinical Nutrition, 99(1), 71-78. [More Information]
  • Levine, M., Suarez, J., Brandhorst, S., Balasubramanian, P., Cheng, C., Madia, F., Fontana, L., Mirisola, M., Guevara-Aguirre, J., et al (2014). Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism, 19(3), 407-417. [More Information]
  • Mattson, M., Allison, D., Fontana, L., Harvie, M., Longo, V., Malaisse, W., Mosley, M., Notterpek, L., Ravussin, E., Scheer, F., et al (2014). Meal frequency and timing in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16647-16653. [More Information]
  • Soare, A., Weiss, E., Holloszy, J., Fontana, L. (2014). Multiple dietary supplements do not affect metabolic and cardiovascular health. Aging, 6(2), 149-157.
  • Fontana, L., Hu, F. (2014). Optimal body weight for health and longevity: Bridging basic, clinical, and population research. Aging Cell, 13(3), 391-400. [More Information]
  • Weiss, E., Royer, N., Fisher, J., Holloszy, J., Fontana, L. (2014). Postprandial plasma incretin hormones in exercise-trained versus untrained subjects. Medicine and Science in Sports and Exercise, 46(6), 1098-1103. [More Information]
  • Gallo, F., Salani, B., Mazzucchelli, C., Bordone, C., Fontana, L., Maggi, D., Cordera, R. (2014). The clinical pathophysiology of diabetic foot [Fisiopatologia clinica del piede diabetico]. Giornale Italiano di Diabetologia e Metabolismo, 34(1), 22-31.
  • Rizza, W., Veronese, N., Fontana, L. (2014). What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Research Reviews, 13(1), 38-45. [More Information]
  • Mercken, E., Crosby, S., Lamming, D., JeBailey, L., Krzysik-Walker, S., Villareal, D., Capri, M., Franceschi, C., Zhang, Y., Fontana, L., et al (2013). Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell, 12(4), 645-651. [More Information]
  • Fontana, L., Adelaiye, R., Rastelli, A., Miles, K., Ciamporcero, E., Longo, V., Nguyen, H., Vessella, R., Pili, R. (2013). Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer. Oncotarget, 4(12), 2451-2461.
  • Fontana, L., Atella, V., Kammen, D. (2013). Energy efficiency as a unifying principle for human, environmental, and global health. F1000Research, 2, 1-12. [More Information]
  • Fontana, L., Addante, F., Copetti, M., Paroni, G., Fontana, A., Sancarlo, D., Pellegrini, F., Ferrucci, L., Pilotto, A. (2013). Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients. Aging Cell, 12(3), 459-466. [More Information]
  • Parrella, E., Maxim, T., Maialetti, F., Zhang, L., Wan, J., Wei, M., Cohen, P., Fontana, L., Longo, V. (2013). Protein restriction cycles reduce IGF-1 and phosphorylated tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell, 12(2), 257-268. [More Information]
  • Omodei, D., Licastro, D., Salvatore, F., Crosby, S., Fontana, L. (2013). Serum from humans on long term calorie restriction enhances stress resistance in cell culture. Aging, 5(8), 599-606.
  • Cava, E., Fontana, L. (2013). Will calorie restriction work in humans? Aging, 5(7), 507-514.
  • Stein, P., Soare, A., Meyer, T., Cangemi, R., Holloszy, J., Fontana, L. (2012). Caloric restriction may reverse age-related autonomic decline in humans. Aging Cell, 11(4), 644-650. [More Information]
  • Weiss, E., Villareal, D., Ehsani, A., Fontana, L., Holloszy, J. (2012). Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness. Aging Cell, 11(5), 876-884. [More Information]
  • Paroni, G., Addante, F., Seripa, D., Panza, F., Copetti, M., Fontana, L., Pilotto, A. (2012). Forkhead-box-O1 locus and metabolic markers in the elderly: An association study [Forkhead-box-O1 locus y marcadores metab�licos en los ancianos: Estudio de asociaci�n]. Revista Espanola de Geriatria y Gerontologia, 47(6), 254-258. [More Information]
  • Fontana, L., Vinciguerra, M., Longo, V. (2012). Growth factors, nutrient signaling, and cardiovascular aging. Circulation Research, 110(8), 1139-1150. [More Information]
  • Paroni, G., Seripa, D., Panza, F., Addante, F., Copetti, M., D'Onofrio, G., Pellegrini, F., Fontana, L., Pilotto, A. (2012). Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: A genetic association analysis. Age, 34(4), 949-968. [More Information]
  • Murphy, J., McDaniel, J., Mora, K., Villareal, D., Fontana, L., Weiss, E. (2012). Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction. Journal of Applied Physiology, 112(1), 79-85. [More Information]
  • Cava, E., Fontana, L. (2012). Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metabolism, 16(5), 658-664. [More Information]
  • Niekamp, K., Zavorsky, G., Fontana, L., McDaniel, J., Villareal, D., Weiss, E. (2012). Systemic acid load from the diet affects maximal-exercise RER. Medicine and Science in Sports and Exercise, 44(4), 709-715. [More Information]
  • Weiss, E., Fontana, L. (2011). Caloric restriction: Powerful protection for the aging heart and vasculature. American Journal of Physiology: Heart and Circulatory Physiology, 301(4), H1205-H1219. [More Information]
  • Omodei, D., Fontana, L. (2011). Calorie restriction and prevention of age-associated chronic disease. FEBS Letters, 585(11), 1537-1542. [More Information]
  • Muegge, B., Kuczynski, J., Knights, D., Clemente, J., Gonzalez, A., Fontana, L., Henrissat, B., Knight, R., Gordon, J. (2011). Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science, 332(6032), 970-974. [More Information]
  • Longo, V., Fontana, L. (2010). Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends In Pharmacological Sciences, 31(2), 89-98. [More Information]
  • Fontana, L., Klein, S., Holloszy, J. (2010). Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age, 32(1), 97-108. [More Information]
  • Fontana, L., Partridge, L., Longo, V. (2010). Extending healthy life span-from yeast to humans. Science, 328(5976), 321-326. [More Information]
  • Raffaghello, L., Safdie, F., Bianchi, G., Dorff, T., Fontana, L., Longo, V. (2010). Fasting and differential chemotherapy protection in patients. Cell Cycle, 9(22), 4474-4476. [More Information]
  • Safdie, F., Dorff, T., Quinn, D., Fontana, L., Wei, M., Lee, C., Cohen, P., Longo, V. (2009). Fasting and cancer treatment in humans: A case series report. Aging, 1(12), 988-1007.
  • Fontana, L. (2009). The scientific basis of caloric restriction leading to longer life. Current Opinion in Gastroenterology, 25(2), 144-150. [More Information]
  • Hofer, T., Fontana, L., Anton, S., Weiss, E., Villareal, D., Malayappan, B., Leeuwenburgh, C. (2008). Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Research, 11(4), 793-799. [More Information]
  • Fontana, L., Weiss, E., Villareal, D., Klein, S., Holloszy, J. (2008). Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell, 7(5), 681-687. [More Information]
  • Fontana, L., Klein, S. (2007). Aging, adiposity, and calorie restriction. JAMA - Journal of the American Medical Association, 297(9), 986-994. [More Information]
  • Fontana, L., Villareal, D., Weiss, E., Racette, S., Steger-May, K., Klein, S., Holloszy, J. (2007). Calorie restriction or exercise: Effects on coronary heart disease risk factors. A randomized, controlled trial. American Journal of Physiology: Endocrinology and Metabolism, 293(1), E197-E202. [More Information]
  • Weiss, E., Racette, S., Villareal, D., Fontana, L., Steger-May, K., Schechtman, K., Klein, S., Ehsani, A., Holloszy, J. (2007). Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. Journal of Applied Physiology, 102(2), 634-640. [More Information]
  • Fontana, L., Eagon, J., Trujillo, M., Scherer, P., Klein, S. (2007). Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes, 56(4), 1010-1013. [More Information]
  • Villareal, D., Fontana, L., Weiss, E., Racette, S., Steger-May, K., Schechtman, K., Klein, S., Holloszy, J. (2006). Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: A randomized controlled trial. Archives of Internal Medicine, 166(22), 2502-2510. [More Information]
  • Villareal, D., Miller III, B., Banks, M., Fontana, L., Sinacore, D., Klein, S. (2006). Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. American Journal of Clinical Nutrition, 84(6), 1317-1323.
  • Fontana, L., Klein, S., Holloszy, J., Premachandra, B. (2006). Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. Journal of Clinical Endocrinology and Metabolism, 91(8), 3232-3235. [More Information]
  • Weiss, E., Racette, S., Villareal, D., Fontana, L., Steger-May, K., Schechtman, K., Klein, S., Holloszy, J. (2006). Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: A randomized controlled trial. American Journal of Clinical Nutrition, 84(5), 1033-1042.
  • Meyer, T., Kovacs, S., Ehsani, A., Klein, S., Holloszy, J., Fontana, L. (2006). Long-term caloric restriction ameliorates the decline in diastolic function in humans. Journal of the American College of Cardiology, 47(2), 398-402. [More Information]
  • Fontana, L., Klein, S., Holloszy, J. (2006). Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. American Journal of Clinical Nutrition, 84(6), 1456-1462.
  • Racette, S., Weiss, E., Villareal, D., Arif, H., Steger-May, K., Schechtman, K., Fontana, L., Klein, S., Holloszy, J. (2006). One year of caloric restriction in humans: Feasibility and effects on body composition and abdominal adipose tissue. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61(9), 943-950. [More Information]
  • Klein, S., Fontana, L., Young, V., Coggan, A., Kilo, C., Patterson, B., Mohammed, B. (2004). Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. New England Journal of Medicine, 350(25), 2549-2557. [More Information]
  • Agostoni, A., Aygoren-Pursun, E., Binkley, K., Blanch, A., Bork, K., Bouillet, L., Bucher, C., Castaldo, A., Fontana, L., et al (2004). Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. Journal of Allergy and Clinical Immunology, 114(3 SUPPL.), S51-S131. [More Information]
  • Fontana, L., Meyer, T., Klein, S., Holloszy, J. (2004). Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6659-6663. [More Information]

2018

  • Contreras, N., Fontana, L., Tosti, V., Nikolich-Zugich, J. (2018). Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution. GeroScience, 40(3), 279-291. [More Information]
  • Veronese, N., Solmi, M., Caruso, M., Giannelli, G., Osella, A., Evangelou, E., Maggi, S., Fontana, L., Stubbs, B., Tzoulaki, I. (2018). Dietary fiber and health outcomes: An umbrella review of systematic reviews and meta-analyses. American Journal of Clinical Nutrition, 107(3), 436-444. [More Information]
  • Il'yasova, D., Fontana, L., Bhapkar, M., Pieper, C., Spasojevic, I., Redman, L., Das, S., Huffman, K., Kraus, W. (2018). Effects of 2�years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial. Aging Cell, 17(2), 1-9. [More Information]
  • Tosti, V., Bertozzi, B., Fontana, L. (2018). Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(3), 318-326. [More Information]
  • Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L., Phillips, D., Weinstock, G., Fontana, L., Cross, A., et al (2018). Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota. Cell Metabolism, 27(6), 1222-1235. [More Information]
  • Fontana, L. (2018). Interventions to promote cardiometabolic health and slow cardiovascular ageing. Nature Reviews Cardiology, 15(9), 566-577. [More Information]
  • Pili, R., Fontana, L. (2018). Low-protein diet in cancer: Ready for prime time? Nature Reviews Endocrinology, 14(7), 384-386. [More Information]
  • Fontana, L., Mitchell, S., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D., Maissan, P., Speakman, J., et al (2018). The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon. Aging Cell, 17(3). [More Information]

2017

  • Veronese, N., Stubbs, B., Fontana, L., Trevisan, C., Bolzetta, F., De Rui, M., Sartori, L., Musacchio, E., Zambon, S., Maggi, S., et al (2017). A comparison of objective physical performance tests and future mortality in the elderly people. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(3), 362-368. [More Information]
  • Das, S., Roberts, S., Bhapkar, M., Villareal, D., Fontana, L., Martin, C., Racette, S., Fuss, P., Kraus, W., et al (2017). Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: A 2-y randomized controlled trial of calorie restriction in nonobese humans. American Journal of Clinical Nutrition, 105(4), 913-927. [More Information]
  • Most, J., Tosti, V., Redman, L., Fontana, L. (2017). Calorie restriction in humans: An update. Ageing Research Reviews, 39, 36-45. [More Information]
  • Simpson, S., Le Couteur, D., Raubenheimer, D., Solon-Biet, S., Cooney, G., Cogger, V., Fontana, L. (2017). Dietary protein, aging and nutritional geometry. Ageing Research Reviews, 39, 78-86. [More Information]
  • Racette, S., Rochon, J., Uhrich, M., Villareal, D., Das, S., Fontana, L., Bhapkar, M., Martin, C., Redman, L., Fuss, P., et al (2017). Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Medicine and Science in Sports and Exercise, 49(11), 2240-2249. [More Information]
  • Veronese, N., Stubbs, B., Noale, M., Solmi, M., Vaona, A., Demurtas, J., Nicetto, D., Crepaldi, G., Schofield, P., Koyanagi, A., et al (2017). Fried potato consumption is associated with elevated mortality: An 8-y longitudinal cohort study. American Journal of Clinical Nutrition, 106(1), 162-167. [More Information]
  • Eitan, E., Tosti, V., Suire, C., Cava, E., Berkowitz, S., Bertozzi, B., Raefsky, S., Veronese, N., Spangler, R., Spelta, F., et al (2017). In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles. Aging Cell, 16(6), 1430-1433. [More Information]
  • Magni, P., Bier, D., Pecorelli, S., Agostoni, C., Astrup, A., Brighenti, F., Cook, R., Folco, E., Fontana, L., Gibson, R., et al (2017). Perspective: Improving nutritional guidelines for sustainable health policies: Current status and perspectives. Advances in Nutrition, 8(4), 532-545. [More Information]
  • Griffin, N., Ahern, P., Cheng, J., Heath, A., Ilkayeva, O., Newgard, C., Fontana, L., Gordon, J. (2017). Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. Cell Host and Microbe, 21(1), 84-96. [More Information]
  • Ruggenenti, P., Abbate, M., Ruggiero, B., Rota, S., Trillini, M., Aparicio, C., Parvanova, A., Iliev, I., Pisanu, G., Fontana, L., et al (2017). Renal and systemic effects of calorie restriction in patients with type 2 diabetes with abdominal obesity: A randomized controlled trial. Diabetes, 66(1), 75-86. [More Information]
  • Veronese, N., Cereda, E., Stubbs, B., Solmi, M., Luchini, C., Manzato, E., Sergi, G., Manu, P., Harris, T., Fontana, L., et al (2017). Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis. Ageing Research Reviews, 35, 63-73. [More Information]
  • Lamming, D., Baar, E., Arriola Apelo, S., Tosti, V., Fontana, L. (2017). Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice. Nutrition and Healthy Aging, 4(3), 239-245. [More Information]
  • Veronese, N., Facchini, S., Stubbs, B., Luchini, C., Solmi, M., Manzato, E., Sergi, G., Maggi, S., Cosco, T., Fontana, L. (2017). Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 72, 87-94. [More Information]

2016

  • Bertozzi, B., Tosti, V., Fontana, L. (2016). Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being. Gerontology, 63(1), 13-19. [More Information]
  • Veronese, N., Li, Y., Manson, J., Willett, W., Fontana, L., Hu, F. (2016). Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: Prospective cohort study. BMJ, 355, 1-7. [More Information]
  • Fontana, L., Cummings, N., Arriola Apelo, S., Neuman, J., Kasza, I., Schmidt, B., Cava, E., Spelta, F., Tosti, V., et al (2016). Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health. Cell Reports, 16(2), 520-530. [More Information]
  • Villareal, D., Fontana, L., Das, S., Redman, L., Smith, S., Saltz�man, E., Bales, C., Rochon, J., Pieper, C., Huang, M., et al (2016). Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. Journal of Bone and Mineral Research, 31(1), 40-51. [More Information]
  • Fontana, L., Villareal, D., Das, S., Smith, S., Meydani, S., Pittas, A., Klein, S., Bhapkar, M., Rochon, J., Ravussin, E., et al (2016). Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: A randomized clinical trial. Aging Cell, 15(1), 22-27. [More Information]
  • Veronese, N., Stubbs, B., Fontana, L., Trevisan, C., Bolzetta, F., De Rui, M., Sartori, L., Musacchio, E., Zambon, S., Maggi, S., et al (2016). Frailty Is Associated with an Increased Risk of Incident Type 2 Diabetes in the Elderly. Journal of the American Medical Directors Association (JAMDA), 17(10), 902-907. [More Information]
  • Yang, L., Licastro, D., Cava, E., Veronese, N., Spelta, F., Rizza, W., Bertozzi, B., Villareal, D., Fontana, L., et al (2016). Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle. Cell Reports, 14(3), 422-428. [More Information]
  • Meydani, S., Das, S., Pieper, C., Lewis, M., Klein, S., Dixit, V., Gupta, A., Villareal, D., Bhapkar, M., Fontana, L., et al (2016). Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: A randomized controlled trial in non-obese humans. Aging, 8(7), 1416-1431. [More Information]
  • Nikolich-Zugich, J., Goldman, D., Cohen, P., Cortese, D., Fontana, L., Kennedy, B., Mohler, M., Olshansky, S., Perls, T., Perry, D., et al (2016). Preparing for an aging world: Engaging biogerontologists, geriatricians, and the society. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(4), 435-444. [More Information]

2015

  • Ravussin, E., Redman, L., Rochon, J., Das, S., Fontana, L., Kraus, W., Romashkan, S., Williamson, D., Meydani, S., Villareal, D., et al (2015). A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70(9), 1097-1104. [More Information]
  • Atella, V., Kopinska, J., Medea, G., Belotti, F., Tosti, V., Mortari, A., Cricelli, C., Fontana, L. (2015). Excess body weight increases the burden of age-associated chronic diseases and their associated health care expenditures. Aging, 7(10), 882-892.
  • Omodei, D., Pucino, V., Labruna, G., Procaccini, C., Galgani, M., Perna, F., Pirozzi, D., De Caprio, C., Marone, G., Fontana, L., et al (2015). Immune-metabolic profiling of anorexic patients reveals an anti-oxidant and anti-inflammatory phenotype. Metabolism: Clinical and Experimental, 64(3), 396-405. [More Information]
  • Longo, V., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H., Caruso, C., Curiel, T., de Cabo, R., Fontana, L., et al (2015). Interventions to slow aging in humans: Are we ready? Aging Cell, 14(4), 497-510. [More Information]
  • Sergi, G., Veronese, N., Fontana, L., De Rui, M., Bolzetta, F., Zambon, S., Corti, M., Baggio, G., Toffanello, E., et al (2015). Pre-frailty and risk of cardiovascular disease in elderly men and women: The Pro.V.A. Study. Journal of the American College of Cardiology, 65(10), 976-983. [More Information]
  • Fontana, L., Partridge, L. (2015). Promoting health and longevity through diet: From model organisms to humans. Cell, 161(1), 106-118. [More Information]
  • Dey, N., Wagner, V., Blanton, L., Cheng, J., Fontana, L., Haque, R., Ahmed, T., Gordon, J. (2015). Regulators of Gut Motility Revealed by a Gnotobiotic Model of Diet-Microbiome Interactions Related to Travel. Cell, 163(1), 95-107. [More Information]
  • Lamming, D., Cummings, N., Rastelli, A., Gao, F., Cava, E., Bertozzi, B., Spelta, F., Pili, R., Fontana, L. (2015). Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model. Oncotarget, 6(31), 31233-31240. [More Information]

2014

  • Redman, L., Kraus, W., Bhapkar, M., Das, S., Racette, S., Martin, C., Fontana, L., Wong, W., Roberts, S., Ravussin, E. (2014). Energy requirements in nonobese men and women: Results from CALERIE. American Journal of Clinical Nutrition, 99(1), 71-78. [More Information]
  • Levine, M., Suarez, J., Brandhorst, S., Balasubramanian, P., Cheng, C., Madia, F., Fontana, L., Mirisola, M., Guevara-Aguirre, J., et al (2014). Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism, 19(3), 407-417. [More Information]
  • Mattson, M., Allison, D., Fontana, L., Harvie, M., Longo, V., Malaisse, W., Mosley, M., Notterpek, L., Ravussin, E., Scheer, F., et al (2014). Meal frequency and timing in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16647-16653. [More Information]
  • Weiss, E., Fontana, L. (2014). Metabolic consequences of calorie restriction. In A. Catharine Ross (Eds.), Modern Nutrition in Health and Disease: Eleventh Edition, (pp. 678-683). Philadelphia: Wolters Kluwer Health Adis.
  • Soare, A., Weiss, E., Holloszy, J., Fontana, L. (2014). Multiple dietary supplements do not affect metabolic and cardiovascular health. Aging, 6(2), 149-157.
  • Fontana, L., Hu, F. (2014). Optimal body weight for health and longevity: Bridging basic, clinical, and population research. Aging Cell, 13(3), 391-400. [More Information]
  • Weiss, E., Royer, N., Fisher, J., Holloszy, J., Fontana, L. (2014). Postprandial plasma incretin hormones in exercise-trained versus untrained subjects. Medicine and Science in Sports and Exercise, 46(6), 1098-1103. [More Information]
  • Gallo, F., Salani, B., Mazzucchelli, C., Bordone, C., Fontana, L., Maggi, D., Cordera, R. (2014). The clinical pathophysiology of diabetic foot [Fisiopatologia clinica del piede diabetico]. Giornale Italiano di Diabetologia e Metabolismo, 34(1), 22-31.
  • Rizza, W., Veronese, N., Fontana, L. (2014). What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Research Reviews, 13(1), 38-45. [More Information]

2013

  • Mercken, E., Crosby, S., Lamming, D., JeBailey, L., Krzysik-Walker, S., Villareal, D., Capri, M., Franceschi, C., Zhang, Y., Fontana, L., et al (2013). Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell, 12(4), 645-651. [More Information]
  • Fontana, L., Adelaiye, R., Rastelli, A., Miles, K., Ciamporcero, E., Longo, V., Nguyen, H., Vessella, R., Pili, R. (2013). Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer. Oncotarget, 4(12), 2451-2461.
  • Fontana, L., Atella, V., Kammen, D. (2013). Energy efficiency as a unifying principle for human, environmental, and global health. F1000Research, 2, 1-12. [More Information]
  • Fontana, L., Addante, F., Copetti, M., Paroni, G., Fontana, A., Sancarlo, D., Pellegrini, F., Ferrucci, L., Pilotto, A. (2013). Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients. Aging Cell, 12(3), 459-466. [More Information]
  • Parrella, E., Maxim, T., Maialetti, F., Zhang, L., Wan, J., Wei, M., Cohen, P., Fontana, L., Longo, V. (2013). Protein restriction cycles reduce IGF-1 and phosphorylated tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell, 12(2), 257-268. [More Information]
  • Omodei, D., Licastro, D., Salvatore, F., Crosby, S., Fontana, L. (2013). Serum from humans on long term calorie restriction enhances stress resistance in cell culture. Aging, 5(8), 599-606.
  • Cava, E., Fontana, L. (2013). Will calorie restriction work in humans? Aging, 5(7), 507-514.

2012

  • Stein, P., Soare, A., Meyer, T., Cangemi, R., Holloszy, J., Fontana, L. (2012). Caloric restriction may reverse age-related autonomic decline in humans. Aging Cell, 11(4), 644-650. [More Information]
  • Weiss, E., Villareal, D., Ehsani, A., Fontana, L., Holloszy, J. (2012). Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness. Aging Cell, 11(5), 876-884. [More Information]
  • Paroni, G., Addante, F., Seripa, D., Panza, F., Copetti, M., Fontana, L., Pilotto, A. (2012). Forkhead-box-O1 locus and metabolic markers in the elderly: An association study [Forkhead-box-O1 locus y marcadores metab�licos en los ancianos: Estudio de asociaci�n]. Revista Espanola de Geriatria y Gerontologia, 47(6), 254-258. [More Information]
  • Fontana, L., Vinciguerra, M., Longo, V. (2012). Growth factors, nutrient signaling, and cardiovascular aging. Circulation Research, 110(8), 1139-1150. [More Information]
  • Paroni, G., Seripa, D., Panza, F., Addante, F., Copetti, M., D'Onofrio, G., Pellegrini, F., Fontana, L., Pilotto, A. (2012). Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: A genetic association analysis. Age, 34(4), 949-968. [More Information]
  • Murphy, J., McDaniel, J., Mora, K., Villareal, D., Fontana, L., Weiss, E. (2012). Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction. Journal of Applied Physiology, 112(1), 79-85. [More Information]
  • Cava, E., Fontana, L. (2012). Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metabolism, 16(5), 658-664. [More Information]
  • Niekamp, K., Zavorsky, G., Fontana, L., McDaniel, J., Villareal, D., Weiss, E. (2012). Systemic acid load from the diet affects maximal-exercise RER. Medicine and Science in Sports and Exercise, 44(4), 709-715. [More Information]

2011

  • Weiss, E., Fontana, L. (2011). Caloric restriction: Powerful protection for the aging heart and vasculature. American Journal of Physiology: Heart and Circulatory Physiology, 301(4), H1205-H1219. [More Information]
  • Omodei, D., Fontana, L. (2011). Calorie restriction and prevention of age-associated chronic disease. FEBS Letters, 585(11), 1537-1542. [More Information]
  • Muegge, B., Kuczynski, J., Knights, D., Clemente, J., Gonzalez, A., Fontana, L., Henrissat, B., Knight, R., Gordon, J. (2011). Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science, 332(6032), 970-974. [More Information]

2010

  • Longo, V., Fontana, L. (2010). Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends In Pharmacological Sciences, 31(2), 89-98. [More Information]
  • Fontana, L., Klein, S., Holloszy, J. (2010). Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age, 32(1), 97-108. [More Information]
  • Fontana, L., Partridge, L., Longo, V. (2010). Extending healthy life span-from yeast to humans. Science, 328(5976), 321-326. [More Information]
  • Raffaghello, L., Safdie, F., Bianchi, G., Dorff, T., Fontana, L., Longo, V. (2010). Fasting and differential chemotherapy protection in patients. Cell Cycle, 9(22), 4474-4476. [More Information]

2009

  • Safdie, F., Dorff, T., Quinn, D., Fontana, L., Wei, M., Lee, C., Cohen, P., Longo, V. (2009). Fasting and cancer treatment in humans: A case series report. Aging, 1(12), 988-1007.
  • Fontana, L. (2009). The scientific basis of caloric restriction leading to longer life. Current Opinion in Gastroenterology, 25(2), 144-150. [More Information]

2008

  • Hofer, T., Fontana, L., Anton, S., Weiss, E., Villareal, D., Malayappan, B., Leeuwenburgh, C. (2008). Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Research, 11(4), 793-799. [More Information]
  • Fontana, L., Weiss, E., Villareal, D., Klein, S., Holloszy, J. (2008). Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell, 7(5), 681-687. [More Information]

2007

  • Fontana, L., Klein, S. (2007). Aging, adiposity, and calorie restriction. JAMA - Journal of the American Medical Association, 297(9), 986-994. [More Information]
  • Fontana, L., Villareal, D., Weiss, E., Racette, S., Steger-May, K., Klein, S., Holloszy, J. (2007). Calorie restriction or exercise: Effects on coronary heart disease risk factors. A randomized, controlled trial. American Journal of Physiology: Endocrinology and Metabolism, 293(1), E197-E202. [More Information]
  • Weiss, E., Racette, S., Villareal, D., Fontana, L., Steger-May, K., Schechtman, K., Klein, S., Ehsani, A., Holloszy, J. (2007). Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. Journal of Applied Physiology, 102(2), 634-640. [More Information]
  • Fontana, L., Eagon, J., Trujillo, M., Scherer, P., Klein, S. (2007). Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes, 56(4), 1010-1013. [More Information]

2006

  • Villareal, D., Fontana, L., Weiss, E., Racette, S., Steger-May, K., Schechtman, K., Klein, S., Holloszy, J. (2006). Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: A randomized controlled trial. Archives of Internal Medicine, 166(22), 2502-2510. [More Information]
  • Villareal, D., Miller III, B., Banks, M., Fontana, L., Sinacore, D., Klein, S. (2006). Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. American Journal of Clinical Nutrition, 84(6), 1317-1323.
  • Fontana, L., Klein, S., Holloszy, J., Premachandra, B. (2006). Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. Journal of Clinical Endocrinology and Metabolism, 91(8), 3232-3235. [More Information]
  • Weiss, E., Racette, S., Villareal, D., Fontana, L., Steger-May, K., Schechtman, K., Klein, S., Holloszy, J. (2006). Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: A randomized controlled trial. American Journal of Clinical Nutrition, 84(5), 1033-1042.
  • Meyer, T., Kovacs, S., Ehsani, A., Klein, S., Holloszy, J., Fontana, L. (2006). Long-term caloric restriction ameliorates the decline in diastolic function in humans. Journal of the American College of Cardiology, 47(2), 398-402. [More Information]
  • Fontana, L., Klein, S., Holloszy, J. (2006). Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. American Journal of Clinical Nutrition, 84(6), 1456-1462.
  • Racette, S., Weiss, E., Villareal, D., Arif, H., Steger-May, K., Schechtman, K., Fontana, L., Klein, S., Holloszy, J. (2006). One year of caloric restriction in humans: Feasibility and effects on body composition and abdominal adipose tissue. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61(9), 943-950. [More Information]

2004

  • Klein, S., Fontana, L., Young, V., Coggan, A., Kilo, C., Patterson, B., Mohammed, B. (2004). Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. New England Journal of Medicine, 350(25), 2549-2557. [More Information]
  • Agostoni, A., Aygoren-Pursun, E., Binkley, K., Blanch, A., Bork, K., Bouillet, L., Bucher, C., Castaldo, A., Fontana, L., et al (2004). Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. Journal of Allergy and Clinical Immunology, 114(3 SUPPL.), S51-S131. [More Information]
  • Fontana, L., Meyer, T., Klein, S., Holloszy, J. (2004). Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6659-6663. [More Information]

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