Dr Lyn Moir

Honorary Associate
Pharmacology, School of Medical Sciences

Telephone +61 2 9114 0360
Fax +61 2 9114 0399

Website Related website

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Research interests

Lymphangioleiomyomatosis (LAM), Asthma, Chronic Obstructive Pulmonary Disease (COPD)

International links

New Zealand

(Malaghan Institute of Medical Research, Wellington) collaboration with Prof Mike Berridge and Dr James Baty

United States

(University of Pennsylvania) collaboration with A/Prof Vera Krymskaya

Selected grants

2011

  • Lamstatin- a novel inhibitor of lymphangiogenesis; Black J, Weckmann M, Moir L; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Black, J., Burgess, J., Oliver, B., Moir, L. (2008). Altered properties of airway smooth muscle in asthma. In Chung, K. (Eds.), Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology, (pp. 181-199). United Kingdom: John Wiley & Sons. [More Information]

Journals

  • Moir, L. (2016). Lymphangioleiomyomatosis: Current understanding and potential treatments. Pharmacology and Therapeutics, 158, 114-124. [More Information]
  • Ng, H., Oliver, B., Burgess, J., Krymskaya, V., Black, J., Moir, L. (2015). Doxycycline reduces the migration of tuberous sclerosis complex-2 null cells - effects on RhoA-GTPase and focal adhesion kinase. Journal of Cellular and Molecular Medicine, 19(11), 2633-2646. [More Information]
  • Haghi, M., van den Oetelaar, W., Moir, L., Zhu, B., Phillips, G., Crapper, J., Young, P., Traini, D. (2015). Inhalable tranexamic acid for haemoptysis treatment. European Journal of Pharmaceutics and Biopharmaceutics, 93, 311-319. [More Information]
  • Alkhouri, H., Moir, L., Armour, C., Hughes, J. (2014). CXCL1 is a negative regulator of mast cell chemotaxis to airway smooth muscle cell products in vitro. Clinical and Experimental Allergy, 44(3), 381-392. [More Information]
  • Alkhouri, H., Cha, V., Tong, K., Moir, L., Armour, C., Hughes, M. (2014). Human Lung Mast Cell Products Regulate Airway Smooth Muscle CXCL10 Levels. Journal of Allergy, 2014, 1-13. [More Information]
  • Grafton, K., Moir, L., Black, J., Hansbro, N., Hansbro, P., Burgess, J., Oliver, B. (2014). LF-15 and T7, Synthetic Peptides Derived from Tumstatin, Attenuate Aspects of Airway Remodelling in a Murine Model of Chronic OVA-Induced Allergic Airway Disease. PloS One, 9(1), 1-6. [More Information]
  • Baker, K., Bonvini, S., Donovan, C., Foong, R., Han, B., Jha, A., Shaifta, Y., Smit, M., Johnson, J., Moir, L. (2014). Novel drug targets for asthma and COPD: lessons learned from in vitro and in vivo models. Pulmonary Pharmacology & Therapeutics, 29(2), 181-198. [More Information]
  • Black, J., Ng, H., Moir, L. (2014). Therapeutic strategies in lymphangioleiomyomatosis (LAM). Respiratory Investigation, 52(1), 3-4. [More Information]
  • Siddiqui, S., Redhu, N., Ojo, O., Liu, B., Irechukwu, N., Billington, C., Janssen, L., Moir, L. (2013). Emerging airway smooth muscle targets to treat asthma. Pulmonary Pharmacology and Therapeutics, 26(1), 132-144. [More Information]
  • Yeganeh, B., Mukherjee, S., Moir, L., Kumawat, K., Kashani, H., Bagchi, R., Baarsma, H., Gosens, R., Ghavami, S. (2013). Novel non-canonical TGF-beta signaling networks: emerging roles in airway smooth muscle phenotype and function. Pulmonary Pharmacology & Therapeutics, 26(1), 50-63. [More Information]
  • Xia, Y., Redhu, N., Moir, L., Koziol-White, C., Ammit, A., Al-Alwan, L., Camoretti-Mercado, B., Clifford, R. (2013). Pro-inflammatory and immunomodulatory functions of airway smooth muscle: Emerging concepts. Pulmonary Pharmacology & Therapeutics, 26(1), 64-74. [More Information]
  • Niimi, K., Ge, Q., Moir, L., Ammit, A., Trian, T., Burgess, J., Black, J., Oliver, B. (2012). B2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers. American Journal of Physiology: Lung Cellular and Molecular Physiology, 302(3), L334-L342. [More Information]
  • Ge, Q., Poniris, M., Moir, L., Black, J., Burgess, J. (2012). Combined Beta-Agonists and Corticosteroids Do Not Inhibit Extracellular Matrix Protein Production In Vitro. Journal of Allergy, 2012, 1-7. [More Information]
  • Weckmann, M., Moir, L., Heckman, C., Black, J., Oliver, B., Burgess, J. (2012). Lamstatin - a novel inhibitor of lymphangiogenesis derived from collagen IV. Journal of Cellular and Molecular Medicine, 16(12), 3062-3073. [More Information]
  • Ge, Q., Moir, L., Trian, T., Niimi, K., Poniris, M., Shepherd, P., Black, J., Oliver, B., Burgess, J. (2012). The phosphoinositide 3'-kinase p110d modulates contractile protein production and IL-6 release in human airway smooth muscle. Journal of Cellular Physiology, 227(8), 3044-3052. [More Information]
  • Moir, L., Black, J., Krymskaya, V. (2012). TSC2 modulates cell adhesion and migration via integrin-a1B1. American Journal of Physiology: Lung Cellular and Molecular Physiology, 303(8), L703-L710. [More Information]
  • Moir, L., Ng, H., Poniris, M., Santa, T., Burgess, J., Oliver, B., Krymskaya, V., Black, J. (2011). Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells. British Journal of Pharmacology, 164(1), 83-92. [More Information]
  • Van Ly, D., King, N., Moir, L., Burgess, J., Black, J., Oliver, B. (2011). Effects of β2 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts. Journal of Allergy, 2011 (Article ID 457169), 1-11. [More Information]
  • Alkhouri, H., Hollins, F., Moir, L., Brightling, C., Armour, C., Hughes, M. (2011). Human lung mast cells modulate the functions of airway smooth muscle cells in asthma. Allergy, 66(9), 1231-1241. [More Information]
  • Moir, L., Trian, T., Ge, Q., Shepherd, P., Burgess, J., Oliver, B., Black, J. (2011). Phosphatidylinositol 3-Kinase Isoform-Specific Effects in Airway Mesenchymal Cell Function. Journal of Pharmacology and Experimental Therapeutics, 337(2), 557-566. [More Information]
  • Trian, T., Burgess, J., Niimi, K., Moir, L., Ge, Q., Berger, P., Liggett, S., Black, J., Oliver, B. (2011). β(2)-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D. PloS One, 6(5), e20000-1-e20000-7. [More Information]
  • Lau, J., Oliver, B., Moir, L., Black, J., Burgess, J. (2010). Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells. Respirology, 15(2), 303-312. [More Information]
  • Lau, J., Oliver, B., Baraket, M., Beckett, E., Hansbro, N., Moir, L., Wilton, S., Williams, C., Foster, P., Hansbro, P., Black, J., Burgess, J. (2010). Fibulin-1 is increased in asthma - a novel mediator of airway remodeling? PloS One, 5(10 (e13360)), 1-13. [More Information]
  • Burgess, J., Boustany, S., Moir, L., Weckmann, M., Lau, J., Grafton, K., Baraket, M., Hansbro, P., Hansbro, N., Foster, P., Black, J., Oliver, B. (2010). Reduction of Tumstatin in Asthmatic Airways Contributes to Angiogenesis, Inflammation and Hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine, 181(2), 106-115. [More Information]
  • Ge, Q., Moir, L., Black, J., Oliver, B., Burgess, J. (2010). TGFBeta1 Induces IL-6 and Inhibits IL-8 Release in Human Bronchial Epithelial Cells: The Role of Smad2/3. Journal of Cellular Physiology, 225(3), 846-854. [More Information]
  • Krimmer, D., Loseli, M., Hughes, M., Oliver, B., Moir, L., Hunt, N., Black, J., Burgess, J. (2009). CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle. Allergy, 64, 1074-1082. [More Information]
  • Trian, T., Qi, G., Moir, L., Burgess, J., Kuo, C., King, N., Reddel, H., Black, J., Oliver, B., McParland, B. (2009). Rhinovirus-induced Exacerbations of Asthma - How is the β2-adrenoceptor Implicated? American Journal of Respiratory Cell and Molecular Biology, 43(2), 227-233. [More Information]
  • Burgess, J., Ceresa, C., Johnson, S., Kanabar, V., Moir, L., Nguyen, T., Oliver, B., Schuliga, M., Ward, J. (2009). Tissue and matrix influences on airway smooth muscle function. Pulmonary Pharmacology and Therapeutics, 22(5), 379-387. [More Information]
  • Moir, L., Burgess, J., Black, J. (2008). Transforming growth factor β1 increases fibronectin deposition through integrin receptor α5β1 on human airway smooth muscle. Journal of Allergy and Clinical Immunology, 121(4), 1034-1039. [More Information]
  • Burgess, J., Moir, L. (2007). Airway Remodeling: Effect of Current and Future Asthma Therapies. Current Respiratory Medicine Reviews, 3(4), 297-308. [More Information]
  • Matsumoto, H., Moir, L., Oliver, B., Burgess, J., Roth, M., Black, J., McParland, B. (2007). Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma. Thorax, 62(10), 848-854. [More Information]
  • Burgess, J., Oliver, B., Poniris, M., Ge, Q., Boustany, S., Cox, N., Moir, L., Johnson, P., Black, J. (2006). A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro. Journal of Allergy and Clinical Immunology, 118(3), 649-657. [More Information]
  • Ammit, A., Moir, L., Oliver, B., Hughes, M., Alkhouri, H., Ge, Q., Burgess, J., Black, J., Roth, M. (2006). The effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. American Journal of Physiology: Lung Cellular and Molecular Physiology, 292(1), L199-L206. [More Information]
  • Black, J., Ge, Q., Boustany, S., Johnson, P., Poniris, M., Glanville, A., Oliver, B., Moir, L., Burgess, J. (2005). In vitro studies of lymphangioleiomyomatosis. European Respiratory Journal, 26(4), 569-576. [More Information]

2016

  • Moir, L. (2016). Lymphangioleiomyomatosis: Current understanding and potential treatments. Pharmacology and Therapeutics, 158, 114-124. [More Information]

2015

  • Ng, H., Oliver, B., Burgess, J., Krymskaya, V., Black, J., Moir, L. (2015). Doxycycline reduces the migration of tuberous sclerosis complex-2 null cells - effects on RhoA-GTPase and focal adhesion kinase. Journal of Cellular and Molecular Medicine, 19(11), 2633-2646. [More Information]
  • Haghi, M., van den Oetelaar, W., Moir, L., Zhu, B., Phillips, G., Crapper, J., Young, P., Traini, D. (2015). Inhalable tranexamic acid for haemoptysis treatment. European Journal of Pharmaceutics and Biopharmaceutics, 93, 311-319. [More Information]

2014

  • Alkhouri, H., Moir, L., Armour, C., Hughes, J. (2014). CXCL1 is a negative regulator of mast cell chemotaxis to airway smooth muscle cell products in vitro. Clinical and Experimental Allergy, 44(3), 381-392. [More Information]
  • Alkhouri, H., Cha, V., Tong, K., Moir, L., Armour, C., Hughes, M. (2014). Human Lung Mast Cell Products Regulate Airway Smooth Muscle CXCL10 Levels. Journal of Allergy, 2014, 1-13. [More Information]
  • Grafton, K., Moir, L., Black, J., Hansbro, N., Hansbro, P., Burgess, J., Oliver, B. (2014). LF-15 and T7, Synthetic Peptides Derived from Tumstatin, Attenuate Aspects of Airway Remodelling in a Murine Model of Chronic OVA-Induced Allergic Airway Disease. PloS One, 9(1), 1-6. [More Information]
  • Baker, K., Bonvini, S., Donovan, C., Foong, R., Han, B., Jha, A., Shaifta, Y., Smit, M., Johnson, J., Moir, L. (2014). Novel drug targets for asthma and COPD: lessons learned from in vitro and in vivo models. Pulmonary Pharmacology & Therapeutics, 29(2), 181-198. [More Information]
  • Black, J., Ng, H., Moir, L. (2014). Therapeutic strategies in lymphangioleiomyomatosis (LAM). Respiratory Investigation, 52(1), 3-4. [More Information]

2013

  • Siddiqui, S., Redhu, N., Ojo, O., Liu, B., Irechukwu, N., Billington, C., Janssen, L., Moir, L. (2013). Emerging airway smooth muscle targets to treat asthma. Pulmonary Pharmacology and Therapeutics, 26(1), 132-144. [More Information]
  • Yeganeh, B., Mukherjee, S., Moir, L., Kumawat, K., Kashani, H., Bagchi, R., Baarsma, H., Gosens, R., Ghavami, S. (2013). Novel non-canonical TGF-beta signaling networks: emerging roles in airway smooth muscle phenotype and function. Pulmonary Pharmacology & Therapeutics, 26(1), 50-63. [More Information]
  • Xia, Y., Redhu, N., Moir, L., Koziol-White, C., Ammit, A., Al-Alwan, L., Camoretti-Mercado, B., Clifford, R. (2013). Pro-inflammatory and immunomodulatory functions of airway smooth muscle: Emerging concepts. Pulmonary Pharmacology & Therapeutics, 26(1), 64-74. [More Information]

2012

  • Niimi, K., Ge, Q., Moir, L., Ammit, A., Trian, T., Burgess, J., Black, J., Oliver, B. (2012). B2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers. American Journal of Physiology: Lung Cellular and Molecular Physiology, 302(3), L334-L342. [More Information]
  • Ge, Q., Poniris, M., Moir, L., Black, J., Burgess, J. (2012). Combined Beta-Agonists and Corticosteroids Do Not Inhibit Extracellular Matrix Protein Production In Vitro. Journal of Allergy, 2012, 1-7. [More Information]
  • Weckmann, M., Moir, L., Heckman, C., Black, J., Oliver, B., Burgess, J. (2012). Lamstatin - a novel inhibitor of lymphangiogenesis derived from collagen IV. Journal of Cellular and Molecular Medicine, 16(12), 3062-3073. [More Information]
  • Ge, Q., Moir, L., Trian, T., Niimi, K., Poniris, M., Shepherd, P., Black, J., Oliver, B., Burgess, J. (2012). The phosphoinositide 3'-kinase p110d modulates contractile protein production and IL-6 release in human airway smooth muscle. Journal of Cellular Physiology, 227(8), 3044-3052. [More Information]
  • Moir, L., Black, J., Krymskaya, V. (2012). TSC2 modulates cell adhesion and migration via integrin-a1B1. American Journal of Physiology: Lung Cellular and Molecular Physiology, 303(8), L703-L710. [More Information]

2011

  • Moir, L., Ng, H., Poniris, M., Santa, T., Burgess, J., Oliver, B., Krymskaya, V., Black, J. (2011). Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells. British Journal of Pharmacology, 164(1), 83-92. [More Information]
  • Van Ly, D., King, N., Moir, L., Burgess, J., Black, J., Oliver, B. (2011). Effects of β2 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts. Journal of Allergy, 2011 (Article ID 457169), 1-11. [More Information]
  • Alkhouri, H., Hollins, F., Moir, L., Brightling, C., Armour, C., Hughes, M. (2011). Human lung mast cells modulate the functions of airway smooth muscle cells in asthma. Allergy, 66(9), 1231-1241. [More Information]
  • Moir, L., Trian, T., Ge, Q., Shepherd, P., Burgess, J., Oliver, B., Black, J. (2011). Phosphatidylinositol 3-Kinase Isoform-Specific Effects in Airway Mesenchymal Cell Function. Journal of Pharmacology and Experimental Therapeutics, 337(2), 557-566. [More Information]
  • Trian, T., Burgess, J., Niimi, K., Moir, L., Ge, Q., Berger, P., Liggett, S., Black, J., Oliver, B. (2011). β(2)-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D. PloS One, 6(5), e20000-1-e20000-7. [More Information]

2010

  • Lau, J., Oliver, B., Moir, L., Black, J., Burgess, J. (2010). Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells. Respirology, 15(2), 303-312. [More Information]
  • Lau, J., Oliver, B., Baraket, M., Beckett, E., Hansbro, N., Moir, L., Wilton, S., Williams, C., Foster, P., Hansbro, P., Black, J., Burgess, J. (2010). Fibulin-1 is increased in asthma - a novel mediator of airway remodeling? PloS One, 5(10 (e13360)), 1-13. [More Information]
  • Burgess, J., Boustany, S., Moir, L., Weckmann, M., Lau, J., Grafton, K., Baraket, M., Hansbro, P., Hansbro, N., Foster, P., Black, J., Oliver, B. (2010). Reduction of Tumstatin in Asthmatic Airways Contributes to Angiogenesis, Inflammation and Hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine, 181(2), 106-115. [More Information]
  • Ge, Q., Moir, L., Black, J., Oliver, B., Burgess, J. (2010). TGFBeta1 Induces IL-6 and Inhibits IL-8 Release in Human Bronchial Epithelial Cells: The Role of Smad2/3. Journal of Cellular Physiology, 225(3), 846-854. [More Information]

2009

  • Krimmer, D., Loseli, M., Hughes, M., Oliver, B., Moir, L., Hunt, N., Black, J., Burgess, J. (2009). CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle. Allergy, 64, 1074-1082. [More Information]
  • Trian, T., Qi, G., Moir, L., Burgess, J., Kuo, C., King, N., Reddel, H., Black, J., Oliver, B., McParland, B. (2009). Rhinovirus-induced Exacerbations of Asthma - How is the β2-adrenoceptor Implicated? American Journal of Respiratory Cell and Molecular Biology, 43(2), 227-233. [More Information]
  • Burgess, J., Ceresa, C., Johnson, S., Kanabar, V., Moir, L., Nguyen, T., Oliver, B., Schuliga, M., Ward, J. (2009). Tissue and matrix influences on airway smooth muscle function. Pulmonary Pharmacology and Therapeutics, 22(5), 379-387. [More Information]

2008

  • Black, J., Burgess, J., Oliver, B., Moir, L. (2008). Altered properties of airway smooth muscle in asthma. In Chung, K. (Eds.), Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology, (pp. 181-199). United Kingdom: John Wiley & Sons. [More Information]
  • Moir, L., Burgess, J., Black, J. (2008). Transforming growth factor β1 increases fibronectin deposition through integrin receptor α5β1 on human airway smooth muscle. Journal of Allergy and Clinical Immunology, 121(4), 1034-1039. [More Information]

2007

  • Burgess, J., Moir, L. (2007). Airway Remodeling: Effect of Current and Future Asthma Therapies. Current Respiratory Medicine Reviews, 3(4), 297-308. [More Information]
  • Matsumoto, H., Moir, L., Oliver, B., Burgess, J., Roth, M., Black, J., McParland, B. (2007). Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma. Thorax, 62(10), 848-854. [More Information]

2006

  • Burgess, J., Oliver, B., Poniris, M., Ge, Q., Boustany, S., Cox, N., Moir, L., Johnson, P., Black, J. (2006). A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro. Journal of Allergy and Clinical Immunology, 118(3), 649-657. [More Information]
  • Ammit, A., Moir, L., Oliver, B., Hughes, M., Alkhouri, H., Ge, Q., Burgess, J., Black, J., Roth, M. (2006). The effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. American Journal of Physiology: Lung Cellular and Molecular Physiology, 292(1), L199-L206. [More Information]

2005

  • Black, J., Ge, Q., Boustany, S., Johnson, P., Poniris, M., Glanville, A., Oliver, B., Moir, L., Burgess, J. (2005). In vitro studies of lymphangioleiomyomatosis. European Respiratory Journal, 26(4), 569-576. [More Information]

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