Professor Michael Davies

Professor
Medicine, Central Clinical School
Heart Research Institute

Telephone +61 2 8208 8900
Fax +61 2 9565 5584

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Biographical details

Michael Davies was awarded his B.Sc. and D.Phil. degrees from University of York, UK. He completed a post-doctoral position at Brunel University, before returning to the University of York as a staff member. In 1995 he moved to the Heart Research Institute, Sydney, Australia, where he is now Deputy Director and a Professor at the University of Sydney.

Research interests

Prof. Davies' research interests lie in the mechanisms of protein modification by reactive species (radicals, two-electron oxidants, glycation reactions), the biological consequences of such reactions, and the development of methods to quantify protein damage in disease. He also has interests in EPR spectroscopy for the detection of transient radicals, the kinetics of oxidant reactions, extracellular matrix damage and the development of antioxidants.

Selected grants

2014

  • Protein oxidation induced by singlet oxygen and peroxyl radicals and its consequences; Davies M, Pattison D; Australian Research Council (ARC)/Discovery Projects (DP).

2013

  • SF-61SX2/s stopped-flow fluorimeter and Service and upgrade of SX-17MV stopped-flow spectrometer; Clarke R, Davies M, Lay P, Witting P, Rasmussen H, Matthews J, Pattison D, Vandenberg J; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Mechanisms and consequences of damage to arterial extracellular matrix induced by reactive nitrogen species; Davies M, Whitelock J; Heart Foundation of Australia/Grants-in-Aid.
  • Multiplexed capabilities for surface analysis and imaging by mass spectrometry; Blanksby S, Davies M, Truscott R; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Are selenium based antioxidants effective in the repair of protein radicals?; Pattison D, Davies M, Anderson R; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.

2010

  • Oxidative Stress Bioanalytical Facility; Stocker R, Hunt N, Mason R, Witting P, Roufogalis B, Lay P, Tiganis T, Davies M, Dawes I, Drummond G, Geczy C, Kachigian L, Hogg P, Lackmann M, Thomas S, Croft K, King N, Tilley L, James D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • How does the structure of nitroxides modulate their efficacy as antioxidants against protein-derived free radicals?; Davies M; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.

2009

  • Does oxidation of lipoproteins by thiocyanate-derived oxidants produced by myeloperoxidase contribute to atherosclerosis; Hawkins C, Davies M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms and control of iron accumulation in atherosclerotic lesions; Davies M; DVC Research/Bridging Support Grant.
  • Mechanisms and consequences of myeloperoxidase-mediated damage to glycosaminoglycans, proteins and proteoglycans; Davies M; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • Development of Iron Chelators for the Treatment of Friedreichs Ataxia and the Role of Frataxin in Mitochondrial Iron Metabolism; Richardson D, Davies M; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Free Radical Chemistry and Biotechnology; Radom L, Davies M, Davies M; Australian Research Council (ARC)/Centres of Excellence (CE).
  • Mitochondrial Iron Overload and Friedreichs Ataxia: The Role of Frataxin in Iron and Haem Metabolism; Richardson D, Davies M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms and consequences of oxidation of glycosaminoglycans, proteins and proteoglycans by myeloperoxidase-derived oxidants; Davies M, Barter P, Rees M; Australian Research Council (ARC)/Discovery Projects (DP).

2005

  • Free Radical Chemistry and Biotechnology; Radom L, Davies M; Australian Research Council (ARC)/Centres of Excellence (CE).
  • Damage to arterial extracellular matrix induced by reactive nitrogen species and its consequences; Davies M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanistic studies on the oxidation of amino acids, peptides and proteins and its biological consequences; Davies M; Australian Research Council (ARC)/Discovery Projects (DP).
  • Mechanisms of oxidised accumulation in ageing cells; Davies M, Rodgers K, Dean R; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • The molecular processes involved in age-related human nuclear cataract; Truscott R, Davies M; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Edited Books

  • Davies, M., Murphy, D., Gilbert, B. (2008). Electron Paramagnetic Resonance. United Kingdom: Royal Society of Chemistry.

Book Chapters

  • Davies, M. (2009). Electron parametric resonance detection of radicals in biology and medicine. In Marina Brustolon, Elio Giamello (Eds.), Electron Paramagnetic Resonance: A Practitioners Toolkit, (pp. 427-450). United States: John Wiley & Sons.
  • Hawkins, C., Pattison, D., Whiteman, M., Davies, M. (2007). Chlorination and nitration of DNA and nucleic acid components. In Evans M; Cooke M (Eds.), Oxidative Damage to Nucleic Acids, (pp. 14-39). United States: Springer.
  • Davies, M., Brown, B., Imran, R., van Reyk, D. (2006). The roles of protein glycation, glycoxidation and advanced glycation end-product formation in diabetes-induced atherosclerosis. In Sukhinder C. Kaur Cheema (Eds.), Biochemistry of Atherosclerosis (Advances in Biochemistry in Health and Disease), (pp. 247-283). United States: Springer Science + Business Media.

Journals

  • Dunn, L., Simpson, P., Prosser, H., Lecce (Venuto), L., Yuen, S., Buckle, A., Sieveking, D., Vanags, L., Lim, P., Chow, R., Bao, B., Davies, M., Celermajer, D., Bursill, C., Ng, M., et al (2014). A Critical Role for Thioredoxin Interacting Protein in Diabetes-Related Impairment of Angiogenesis. Diabetes, 63(2), 675-687. [More Information]
  • Hawkins, C., Davies, M. (2014). Detection and characterisation of radicals in biological materials using EPR methodology. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1840 (2), 708-721. [More Information]
  • Gad, N., Mizdrak, J., Pattison, D., Davies, M., Truscott, R., Jamie, J. (2014). Detection, quantification, and total synthesis of novel 3-hydroxykynurenine glucoside-derived metabolites present in human lenses. Investigative Ophthalmology & Visual Science, 55(2), 849-855. [More Information]
  • Karimi Galougahi, K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N., Davies, M., Hawkins, C., Rasmussen, H., Figtree, G. (2014). Glutathionylation Mediates Angiotension II-Induced eNOS Uncoupling, Amplifying NADPH Oxidase-Dependent Endothelial Dysfunction. Journal of the American Heart Association, 3(2), 1-11. [More Information]
  • Nedoboy, P., Morgan, P., Mocatta, T., Richards, M., Winterbourn, C., Davies, M. (2014). High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction. Free Radical Research, 48(10), 1256-1266. [More Information]
  • Kajer, T., Fairfull-Smith, K., Yamasaki, T., Yamada, K., Fu, S., Bottle, S., Hawkins, C., Davies, M. (2014). Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides. Free Radical Biology and Medicine, 70, 96-105. [More Information]
  • Storkey, C., Pattison, D., Gaspard, D., Hagestuen, E., Davies, M. (2014). Mechanisms of degradation of the natural high-potency sweetener (2R,4R)-monatin in mock beverage solutions. Journal of Agricultural and Food Chemistry, 62(15), 3476-3487. [More Information]
  • Chuang, C., Degendorfer, G., Davies, M. (2014). Oxidation and modification of extracellular matrix and its role in disease. Free Radical Research, 48(9), 970-989. [More Information]
  • Chuang, C., Degendorfer, G., Hammer, A., Whitelock, J., Malle, E., Davies, M. (2014). Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells. The Biochemical Journal, 459(2), 313-322. [More Information]
  • Morgan, P., Sheahan, P., Davies, M. (2014). Perturbation of Human Coronary Artery Endothelial Cell Redox State and NADPH Generation by Methylglyoxal. PLoS One, 9(1), e86564. [More Information]
  • Storkey, C., Davies, M., Pattison, D. (2014). Reevaluation of the rate constants for the reaction of hypochlorous acid (HOCl) with cysteine, methionine, and peptide derivatives using a new competition kinetic approach. Free Radical Biology and Medicine, 73, 60-66. [More Information]
  • Brown, B., Kim, C., Torpy, F., Bursill, C., McRobb, L., Heather, A., Davies, M., van Reyk, D. (2014). Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E(-/-) mice. Atherosclerosis, 232(2), 403-409. [More Information]
  • Lord, M., Chuang, C., Melrose, J., Davies, M., Iozzo, R., Whitelock, J. (2014). The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling. Matrix Biology, 35, 112-122. [More Information]
  • Talib, J., Kwan, J., Suryo Rahmanto, A., Witting, P., Davies, M. (2014). The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction. The Biochemical Journal, 457(1), 89-97. [More Information]
  • Brown, B., Nobecourt, E., Zeng, J., Jenkins, A., Rye, K., Davies, M. (2013). Apolipoprotein A-I glycation by Glucose and Reactive Aldehydes Alters Phospholipid Affinity but Not Cholesterol Export from Lipid-Laden Macrophages. PLoS One, 8(5), 1-9. [More Information]
  • Kadiiska, M., Basu, S., Brot, N., Cooper, C., Csallany, S., Davies, M., George, M., Murray, D., Roberts, J., Shigenaga, M., et al (2013). Biomarkers of oxidative stress study V: Ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine. Free Radical Biology and Medicine, 61, 408-415. [More Information]
  • Arenas, A., López-Alarcón, C., Kogan, M., Lissi, E., Davies, M., Silva, E. (2013). Chemical modification of lysozyme, glucose 6-phosphate dehydrogenase, and bovine eye lens proteins induced by peroxyl radicals: Role of oxidizable amino acid residues. Chemical Research in Toxicology, 26(1), 67-77. [More Information]
  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013). Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free Radical Biology and Medicine, 65, 1352-1362. [More Information]
  • Morgan, P., Sheahan, P., Pattison, D., Davies, M. (2013). Methylglyoxal-induced modification of arginine residues decreases the activity of NADPH-generating enzymes. Free Radical Biology and Medicine, 61, 229-242. [More Information]
  • Hadfield, K., Pattison, D., Brown, B., Hou, L., Rye, K., Davies, M., Hawkins, C. (2013). Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCI). The Biochemical Journal, 449(2), 531-542. [More Information]
  • Thorpe, G., Reodica, M., Davies, M., Heeren, G., Jarolim, S., Pillay, B., Breitenbach, M., Higgins, V., Dawes, I. (2013). Superoxide Radicals have a Protective Role during H2O2 Stress. Molecular Biology of the Cell, 24(18), 2876-2884. [More Information]
  • Thallas-Bonke, V., Coughlan, M., Tan, A., Harcourt, B., Morgan, P., Davies, M., Forbes, J., Bach, L., Cooper, M. (2013). Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content. Nephrology, 18(1), 47-56. [More Information]
  • Graham, G., Davies, M., Day, R., Mohamudally, A., Scott, K. (2013). The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology, 21(3), 201-232. [More Information]
  • Karton, A., O'Reilly, R., Pattison, D., Davies, M., Radom, L. (2012). Computational design of effective, bioinspired HOCI antioxidants: The role of intramolecular C1(+) and H(+) shifts. Journal of the American Chemical Society, 134(46), 19240-19245. [More Information]
  • Davies, M. (2012). Free Radical Research origins. Free Radical Research, 46(1), 1-1. [More Information]
  • Davies, M. (2012). Free Radicals, oxidants, and protein damage. Australian Biochemist, 43(1), 8-12.
  • Talib, J., Pattison, D., Harmer, J., Celermajer, D., Davies, M. (2012). High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine. Free Radical Biology and Medicine, 53(1), 20-29. [More Information]
  • Barrett, T., Pattison, D., Leonard, S., Carroll, K., Davies, M., Hawkins, C. (2012). Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates. Free Radical Biology and Medicine, 52(6), 1075-1085. [More Information]
  • Moheimani, F., Kim, C., Rahmanto, A., van Reyk, D., Davies, M. (2012). Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: A potential contributory factor in diabetes-associated atherosclerosis. Atherosclerosis, 223(1), 144-151. [More Information]
  • Truscott, R., Mizdrak, J., Friedrich, M., Hooi, M., Lyons, B., Jamie, J., Davies, M., Wilmarth, P., David, L. (2012). Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine? Experimental Eye Research, 99(1), 48-54. [More Information]
  • Cook, N., Viola, H., Sharov, V., Hool, L., Schoeneich, C., Davies, M. (2012). Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca(2+)-ATPase activity and perturb Ca(2+) homeostasis in human coronary artery endothelial cells. Free Radical Biology and Medicine, 52(5), 951-961. [More Information]
  • Cook, N., Pattison, D., Davies, M. (2012). Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins. Free Radical Biology and Medicine, 53(11), 2072-2080. [More Information]
  • Pattison, D., Rahmanto, A., Davies, M. (2012). Photo-oxidation of proteins. Photochemical and Photobiological Sciences, 11(1), 38-53. [More Information]
  • Rahmanto, A., Pattison, D., Davies, M. (2012). Photo-oxidation-induced inactivation of the selenium-containing protective enzymes thioredoxin reductase and glutathione peroxidase. Free Radical Biology and Medicine, 53(6), 1308-1316. [More Information]
  • Storkey, C., Pattison, D., White, J., Schiesser, C., Davies, M. (2012). Preventing Protein Oxidation with Sugars: Scavenging of Hypohalous Acids by 5-Selenopyranose and 4-Selenofuranose Derivatives. Chemical Research in Toxicology, 25(11), 2589-2599. [More Information]
  • Morgan, P., Pattison, D., Davies, M. (2012). Quantification of hydroxyl radical-derived oxidation products in peptides containing glycine, alanine, valine, and proline. Free Radical Biology and Medicine, 52(2), 328-339. [More Information]
  • Pattison, D., Davies, M., Hawkins, C. (2012). Reactions and reactivity of myeloperoxidase-derived oxidants: Differential biological effects of hypochlorous and hypothiocyanous acids. Free Radical Research, 46(8), 975-995. [More Information]
  • Stadler, N., Heeneman, S., Voo, S., Stanley, N., Giles, G., Gang, B., Croft, K., Mori, T., Vacata, V., Daemen, M., Davies, M., et al (2012). Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus. Atherosclerosis, 222(2), 512-518. [More Information]
  • Skaff, O., Pattison, D., Morgan, P., Bachana, R., Jain, V., Priyadarsini, I., Davies, M. (2012). Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage. The Biochemical Journal, 441(1), 305-316. [More Information]
  • Rahmanto, A., Davies, M. (2012). Selenium-containing Amino Acids as Direct and Indirect Antioxidants. IUBMB Life, 64(11), 863-871. [More Information]
  • Pattison, D., Lam, M., Shinde, S., Anderson, R., Davies, M. (2012). The nitroxide TEMPO is an efficient scavenger of protein radicals: Cellular and kinetic studies. Free Radical Biology and Medicine, 53, 1664-1674. [More Information]
  • Gracanin, M., Lam, M., Morgan, P., Rodgers, K., Hawkins, C., Davies, M. (2011). Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome. Free Radical Biology and Medicine, 50(2), 389-399. [More Information]
  • Suryo Rahmanto, A., Davies, M. (2011). Catalytic activity of selenomethionine in removing amino acid, peptide, and protein hydroperoxides. Free Radical Biology and Medicine, 51(12), 2288-2299. [More Information]
  • Dalsgaard, T., Nielsen, J., Brown, B., Stadler, N., Davies, M. (2011). Dityrosine, 3,4-dihydroxyphenylalanine (DOPA), and radical formation from tyrosine residues on milk proteins with globular and flexible structures as a result of riboflavin-mediated photo-oxidation. Journal of Agricultural and Food Chemistry, 59(14), 7939-7947. [More Information]
  • Moheimani, F., Tan, J., Brown, B., Heather, A., van Reyk, D., Davies, M. (2011). Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins. Experimental Diabetes Research, 2011 (Article ID 851280), 851280-1-851280-10. [More Information]
  • Morgan, P., Pattison, D., Talib, J., Summers, F., Harmer, J., Celermajer, D., Hawkins, C., Davies, M. (2011). High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. Free Radical Biology and Medicine, 51(9), 1815-1822. [More Information]
  • Kennett, E., Chuang, C., Degendorfer, G., Whitelock, J., Davies, M. (2011). Mechanisms and consequences of oxidative damage to extracellular matrix. Biochemical Society Transactions, 39(5), 1279-1287. [More Information]
  • Davies, M. (2011). Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. Journal of Clinical Biochemistry and Nutrition, 48(1), 8-19. [More Information]
  • Pattison, D., O'Reilly, R., Skaff, O., Radom, L., Anderson, R., Davies, M. (2011). One-electron Reduction of N-chlorinated and N-Brominated Species Is a Source of Radicals and Bromine Atom Formation. Chemical Research in Toxicology, 24(3), 371-382. [More Information]
  • Mai, K., Smith, N., Feng, Z., Katrib, M., Slapeta, J., Slapetova, I., Wallach, M., Luxford, C., Davies, M., Zhang, X., et al (2011). Peroxidase catalysed cross-linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima. International Journal for Parasitology, 41(11), 1157-1164. [More Information]
  • Storkey, C., Davies, M., White, J., Schiesser, C. (2011). Synthesis and antioxidant capacity of 5-selenopyranose derivatives. Chemical Communications, 47(34), 9693-9695. [More Information]
  • Koelsch, M., Mallak, R., Graham, G., Kajer, T., Milligan, M., Nguyen, L., Newsham, D., Keh, J., Kettle, A., Scott, K., Pattison, D., Hawkins, C., Davies, M., et al (2010). Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. Biochemical Pharmacology, 79(8), 1156-1164. [More Information]
  • Suryo Rahmanto, A., Morgan, P., Hawkins, C., Davies, M. (2010). Cellular effects of peptide and protein hydroperoxides. Free Radical Biology and Medicine, 48(8), 1071-1078. [More Information]
  • Rahmanto, A., Morgan, P., Hawkins, C., Davies, M. (2010). Cellular effects of photo-generated oxidants and long-lived, reactive, hydroperoxide photoproducts. Free Radical Biology and Medicine, 49(10), 1505-1515. [More Information]
  • Moheimani, F., Morgan, P., van Reyk, D., Davies, M. (2010). Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: Possible links between diabetes and atherosclerosis. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1802 (6), 561-571. [More Information]
  • Sourris, K., Harcourt, B., Penfold, S., Yap, F., Morley, A., Morgan, P., Davies, M., Baker, S., Jerums, G., Forbes, J. (2010). Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy. Experimental Diabetes Research, 210(974681), 1-9. [More Information]
  • Rees, M., Whitelock, J., Malle, E., Chuang, C., Iozzo, R., Nilasaroya, A., Davies, M. (2010). Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan. Matrix biology: journal of the International Society for Matrix Biology, 29(1), 63-73. [More Information]
  • Nobecourt, E., Tabet, F., Lambert, G., Puranik, R., Bao, B., Yan, L., Davies, M., Brown, B., Jenkins, A., Dusting, G., Barter, P., Rye, K., et al (2010). Nonenzymatic Glycation Impairs the Antiinflammatory Properties of Apolipoprotein A-I. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), 766-772. [More Information]
  • Kennett, E., Rees, M., Malle, E., Hammer, A., Whitelock, J., Davies, M. (2010). Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains. Free Radical Biology and Medicine, 49(2), 282-293. [More Information]
  • Peskin, A., Cox, A., Nagy, P., Morgan, P., Hampton, M., Davies, M., Winterbourn, C. (2010). Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochemical Journal, 432(2), 313-321. [More Information]
  • Szuchman-Sapir, A., Pattison, D., Davies, M., Witting, P. (2010). Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b(5)-mediated heme reduction. Free Radical Biology and Medicine, 48(1), 35-46. [More Information]
  • Lane, A., Tan, J., Hawkins, C., Heather, A., Davies, M. (2010). The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. Biochemical Journal, 430(1), 161-169. [More Information]
  • Morgan, P., Sturgess, A., Davies, M. (2009). Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients. Free Radical Research, 43(2), 117-127. [More Information]
  • Kennett, E., Davies, M. (2009). Glycosaminoglycans are fragmented by hydroxyl, carbonate, and nitrogen dioxide radicals in a site-selective manner: implications for peroxynitrite-mediated damage at sites of inflammation. Free Radical Biology and Medicine, 47(4), 389-400. [More Information]
  • Chapman, A., Skaff, O., Senthilmohan, R., Kettle, A., Davies, M. (2009). Hypobromous acid and bromamine production by neutrophils and modulation by superoxide. Biochemical Journal, 417(3), 773-781. [More Information]
  • Skaff, O., Pattison, D., Davies, M. (2009). Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance. Biochemical Journal, 422(1), 111-117. [More Information]
  • Rees, M., Bottle, S., Fairfull-Smith, K., Malle, E., Whitelock, J., Davies, M. (2009). Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides. Biochemical Journal, 421(1), 79-86. [More Information]
  • Hawkins, C., Morgan, P., Davies, M. (2009). Quantification of protein modification by oxidants. Free Radical Biology and Medicine, 46(8), 965-988. [More Information]
  • Gracanin, M., Hawkins, C., Pattison, D., Davies, M. (2009). Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products. Free Radical Biology and Medicine, 47(1), 92-102. [More Information]
  • Pattison, D., Hawkins, C., Davies, M. (2009). What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach. Chemical Research in Toxicology, 22(5), 807-817. [More Information]
  • Stadler, N., Stanley, N., Heeneman, S., Vacata, V., Daemen, M., Bannon, P., Waltenberger, J., Davies, M. (2008). Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5), 1024-1030. [More Information]
  • Kennett, E., Davies, M. (2008). Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid. Free Radical Biology and Medicine, 45, 716-725. [More Information]
  • Nobécourt, E., Zeng, J., Davies, M., Bronwyn, B., Yadav, S., Barter, P., Rye, K. (2008). Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I. Diabetologia: clinical and experimental diabetes and metabolism, 51(6), 1008-1017. [More Information]
  • Szuchman-Sapir, A., Pattison, D., Ellis, N., Hawkins, C., Davies, M., Witting, P. (2008). Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin. Free Radical Biology and Medicine, 45(6), 789-798. [More Information]
  • Lloyd, M., van Reyk, D., Davies, M., Hawkins, C. (2008). Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid. Biochemical Journal, 414(2), 271-280. [More Information]
  • Summers, F., Morgan, P., Davies, M., Hawkins, C. (2008). Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines. Chemical Research in Toxicology, 21(9), 1832-1840. [More Information]
  • Davies, M., Hawkins, C., Pattison, D., Rees, M. (2008). Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxidants & Redox Signaling, 10(7), 1199-1234. [More Information]
  • Lam, M., Pattison, D., Bottle, S., Keddie, D., Davies, M. (2008). Nitric Oxide and Nitroxides Can Act as Efficient Scavengers of Protein-Derived Free Radicals. Chemical Research in Toxicology, 21(11), 2111-2119. [More Information]
  • Lund, M., Luxford, C., Skibsted, L., Davies, M. (2008). Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links. Biochemical Journal, 410(Part 3), 565-574.
  • Rees, M., Kennett, E., Whitelock, J., Davies, M. (2008). Oxidative damage to extracellular matrix and its role in human pathologies. Free Radical Biology and Medicine, 44(12), 1973-2001. [More Information]
  • Morgan, P., Pattison, D., Hawkins, C., Davies, M. (2008). Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins. Free Radical Biology and Medicine, 45(9), 1279-1289. [More Information]
  • O'Brien, P., Davies, M., Scurry, J., Smith, A., Barton, C., Henderson, M., Saunders, D., Gloss, B., Patterson, K., et, A., Murali, R., Scolyer, R., Scurr, L., deFazio, A. (2008). The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro. British Journal of Cancer, 98(6), 1085-1093. [More Information]
  • Skaff, O., Pattison, D., Davies, M. (2008). The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study. Biochemistry, 47(31), 8237-8245. [More Information]
  • Hawkins, C., Pattison, D., Stanley, N., Davies, M. (2008). Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation. Biochemical Journal, 416(3), 441-452. [More Information]
  • Rashid, I., van Reyk, D., Davies, M. (2007). Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro. FEBS Letters, 581, 1067-1070. [More Information]
  • Rees, M., McNiven, T., Davies, M. (2007). Degradation of extracellular matrix and its components by hypobromous acid. Biochemical Journal, 401(2), 587-596. [More Information]
  • Kennett, E., Davies, M. (2007). Degradation of matrix glycosaminoglycans by peroxynitrite/peroxynitrous acid: evidence for a hydroxyl-radical-like mechanism. Free Radical Biology and Medicine, 42, 1278-1289. [More Information]
  • Brown, B., Rashid, I., van Reyk, D., Davies, M. (2007). Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages. The FEBS Journal, 274, 1530-1541. [More Information]
  • Pattison, D., Hawkins, C., Davies, M. (2007). Hypochlorous Acid-Mediated Protein Oxidation: How Important Are Chloramine Transfer Reactions and Protein Tertiary Structure? Biochemistry, 46(34), 9853-9864. [More Information]
  • Gracanin, M., Davies, M. (2007). Inhibition of protein tyrosine phosphatases by amino acid, peptide, and protein hydroperoxides: potential modulation of cell signaling by protein oxidation products. Free Radical Biology and Medicine, 42, 1543-1551. [More Information]
  • Skaff, O., Pattison, D., Davies, M. (2007). Kinetics of hypobromous acid-mediated oxidation of lipid components and antioxidants. Chemical Research in Toxicology, 20(12), 1980-1988. [More Information]
  • Mizdrak, J., Hains, P., Kalinowski, D., Truscott, R., Davies, M., Jamie, J. (2007). Novel human lens metabolites from normal and cataractous human lenses. Tetrahedron, 63(23), 4990-4999.
  • Dremina, E., Sharov, V., Davies, M., Schoeneich, C. (2007). Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides. Chemical Research in Toxicology, 20(10), 1462-1469. [More Information]
  • Parker, N., Korlimbinis, A., Jamie, J., Davies, M., Truscott, R. (2007). Reversible binding of kynurenine to lens proteins: potential protection by glutathione in young lenses. Investigative Ophthalmology and Visual Science, 48(8), 3705-3713. [More Information]
  • Morgan, P., Sturgess, A., Hennessy, A., Davies, M. (2007). Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis. Free Radical Research, 41(12), 1301-1312. [More Information]
  • Nobecourt, E., Davies, M., Brown, B., Curtiss, L., Bonnet, D., Charlton, F., Januszewski, A., Jenkins, A., Barter, P., Rye, K. (2007). The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin:cholesterol acyltransferase. Diabetologia: clinical and experimental diabetes and metabolism, 50(3), 643-653. [More Information]
  • Mizdrak, J., Hains, P., Truscott, R., Jamie, J., Davies, M. (2007). Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage. Free Radical Biology and Medicine, 44(6), 1108-1119. [More Information]
  • Puranik, R., Nobecourt, E., Bao, B., Davies, M., Barter, P., Celermajer, D., Rye, K. (2006). Abstract 1355: The Impact of Glycation on the Anti-inflammatory Properties of High Density Lipoproteins in vivo. Circulation, 114, II-257-II-258.
  • Pattison, D., Davies, M. (2006). Actions of ultraviolet light on cellular structures. EXS, 96, 131-157. [More Information]
  • Stanley, N., Stadler, N., Woods, A., Bannon, P., Davies, M. (2006). Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions. Free Radical Biology and Medicine, 40(9), 1636-1643. [More Information]
  • Agon, V., Bubb, W., Wright, A., Hawkins, C., Davies, M. (2006). Corrigendum to “Sensitizer-mediated photo-oxidation of histidine residues: Evidence for the formation of reactive side-chain peroxides�? Free Radical Biology and Medicine, 40(12), 2242-2242. [More Information]
  • Wood, G., Easton, C., Rauk, A., Davies, M., Radom, L. (2006). Effect of side chains on competing pathways for beta-scission reactions of peptide-backbone alkoxyl radicals. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 110(34), 10316-10323. [More Information]
  • Zeng, J., DUNLOP, R., Rodgers, K., Davies, M. (2006). Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols. Biochemical Journal, 398(2), 197-206. [More Information]
  • Pattison, D., Davies, M. (2006). Evidence for rapid inter- and intramolecular chlorine transfer reactions of histamine and carnosine chloramines: implications for the prevention of hypochlorous-Acid-mediated damage. Biochemistry, 45(26), 8152-8162. [More Information]
  • Nobecourt, E., Puranik, R., Bao, B., Davies, M., Barter, P., Rye, K. (2006). Evidence that glycation of apolipoprotein A-I inhibits the anti-inflammatory properties of HDL in vivo. Atherosclerosis Supplements, 7, 71.
  • Rees, M., Davies, M. (2006). Heparan sulfate degradation via reductive homolysis of its N-chloro derivatives. Journal of the American Chemical Society, 128(9), 3085-3097. [More Information]
  • Brown, B., Mahroof, F., Cook, N., van Reyk, D., Davies, M. (2006). Hydrazine compounds inhibit glycation of low-density lipoproteins and prevent the in vitro formation of model foam cells from glycolaldehyde-modified low-density lipoproteins. Diabetologia: clinical and experimental diabetes and metabolism, 49(4), 775-783. [More Information]
  • Headlam, H., Gracanin, M., Rodgers, K., Davies, M. (2006). Inhibition of cathepsins and related proteases by amino acid, peptide, and protein hydroperoxides. Free Radical Biology and Medicine, 40(9), 1539-1548. [More Information]
  • Malle, E., Marsche, G., Arnhold, J., Davies, M. (2006). Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. [More Information]
  • Zeng, J., Davies, M. (2006). Protein and low molecular mass thiols as targets and inhibitors of glycation reactions. Chemical Research in Toxicology, 19(12), 1668-1676. [More Information]
  • Pattison, D., Davies, M. (2006). Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases. Current Medicinal Chemistry, 13(27), 3271-3290. [More Information]
  • Moran, D., Jacob, R., Wood, G., Coote, M., Davies, M., O'Hair, R., Easton, C., Radom, L. (2006). Rearrangements in model peptide-type radicals via intramolecular hydrogen-atom transfer. Helvetica Chimica Acta, 89(10), 2254-2272.
  • Agon, V., Bubb, W., Wright, A., Hawkins, C., Davies, M. (2006). Sensitizer-mediated photooxidation of histidine residues: evidence for the formation of reactive side-chain peroxides. Free Radical Biology and Medicine, 40(4 to 5), 698-710. [More Information]
  • Rees, M., Davies, M. (2005). EPR studies of spin trap adducts of carbohydrate radicals: recognition of adduct isomerism and chirality. Current Topics in Biophysics, 29, 11-24.
  • Zeng, J., Davies, M. (2005). Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins. Chemical Research in Toxicology, 18(8), 1232-1241. [More Information]
  • Brown, B., Dean, R., Davies, M. (2005). Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells. Diabetologia: clinical and experimental diabetes and metabolism, 48(2), 361-369. [More Information]
  • Furukawa, A., Hiraku, Y., Oikawa, S., Luxford, C., Davies, M., Kawanishi, S. (2005). Guanine-specific DNA damage induced by gamma-irradiated histone. Biochemical Journal, 388(Part 3), 813-818.
  • Hawkins, C., Davies, M. (2005). Inactivation of protease inhibitors and lysozyme by hypochlorous acid: role of side-chain oxidation and protein unfolding in loss of biological function. Chemical Research in Toxicology, 18(10), 1600-1610.
  • Morgan, P., Sturgess, A., Davies, M. (2005). Increased Levels of Serum Protein Oxidation and Correlation With Disease Activity in Systemic Lupus Erythematosus. Arthritis and Rheumatism, 52(7), 2069-2079. [More Information]
  • Pattison, D., Davies, M. (2005). Kinetic analysis of the role of histidine chloramines in hypochlorous acid mediated protein oxidation. Biochemistry, 44(19), 7378-7387. [More Information]
  • Birinyi-Strachan, L., Davies, M., Lewis, R., Nicholson, G. (2005). Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: a comparison with other osmotic agents and free radical scavengers. Neuropharmacology, 49(5), 669-686. [More Information]
  • Rees, M., Pattison, D., Davies, M. (2005). Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation. Biochemical Journal, 391(Pt 1), 125-134. [More Information]
  • Sheil, M., Luxford, C., Davies, M., Peat, J., Nunn, G., Celermajer, D. (2005). Protein oxidation injury occurs during pediatric cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery, 130(4), 1054-1061. [More Information]
  • Davies, M. (2005). The oxidative environment and protein damage. BBA - Bioenergetics, 1703 (2), 93-109. [More Information]
  • Hawkins, C., Davies, M. (2005). The Role of Aromatic Amino Acid Oxidation, Protein Unfolding, and Aggregation in the Hypobromous Acid-Induced Inactivation of Trypsin Inhibitor and Lysozyme. Chemical Research in Toxicology, 18(11), 1669-1677. [More Information]
  • Hawkins, C., Davies, M. (2005). The role of reactive N-bromo species and radical intermediates in hypobromous acid-induced protein oxidation. Free Radical Biology and Medicine. [More Information]
  • Stadler, N., Lindner, R., Davies, M. (2004). Direct Detection And Quantification Of Transition Metal Ions In Human Atherosclerotic Plaques: Evidence For The Presence Of Elevated Levels Of Iron And Copper. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(5), 949-954.
  • Davies, M., Hawkins, C. (2004). EPR spin trapping of protein radicals. Free Radical Biology and Medicine, 36(9), 1072-1086. [More Information]
  • Rees, M., Hawkins, C., Davies, M. (2004). Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates. Biochemical Journal, 381(1), 175-184.
  • Pattison, D., Davies, M. (2004). Kinetic Analysis Of The Reactions Of Hypobromous Acid With Protein Components: Implications For Cellular Damage And Use Of 3-Bromotyrosine As A Marker Of Oxidative Stress. Biochemistry, 43(16), 4799-4809.
  • Headlam, H., Davies, M. (2004). Markers Of Protein Oxidation: Different Oxidants Give Rise To Variable Yields Of Bound And Released Carbonyl Products. Free Radical Biology and Medicine, 36(12), 1175-1184. [More Information]
  • Heinzelmann-Schwarz, V., Gardiner-Garden, M., Henshall, S., Scurry, J., Scolyer, R., Davies, M., Heinzelmann, M., Kalish, L., Bali, A., Kench, J., et al (2004). Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. Clinical Cancer Research, 10(13), 4427-4436. [More Information]
  • Morgan, P., Dean, R., Davies, M. (2004). Protective Mechanisms Against Peptide And Protein Peroxides Generated By Singlet Oxygen. Free Radical Biology and Medicine, 36(4), 484-496. [More Information]
  • Parker, N., Jamie, J., Davies, M., Truscott, R. (2004). Protein-Bound Kynurenine Is A Photosensitizer Of Oxidative Damage. Free Radical Biology and Medicine, 37(9), 1479-1489. [More Information]
  • Davies, M. (2004). Reactive Species Formed On Proteins Exposed To Singlet Oxygen. Photochemical and Photobiological Sciences, 3(1), 17-25.
  • Winterbourn, C., Parsons-Mair, H., Gebicki, S., Gebicki, J., Davies, M. (2004). Requirements For Superoxide-Dependent Tyrosine Hydroperoxide Formation In Peptides. Biochemical Journal, 381(Part 1), 241-248.
  • Headlam, H., Davies, M. (2003). Cell-mediated reduction of protein and peptide hydroperoxides to reactive free radicals. Free Radical Biology and Medicine, 34(1), 44-55.
  • Woods, A., Linton, S., Davies, M. (2003). Detection of HOCI- mediated protein oxidation in the extracellular matrix of human atherosclerotic plaques. Biochemical Journal, 370(2), 729-735.
  • Clancy, J., Henderson, M., Russell, A., Anderson, D., Bova, R., Campbell, I., Choong, D., Macdonald, G., Mann, G., Nolan, T., Davies, M., et al (2003). EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. Oncogene, 22(32), 5070-5081. [More Information]
  • Woods, A., Davies, M. (2003). Fragmentation of extracellular matrix by hypochlorous acid. Biochemical Journal, 376(1), 219-227.
  • Knott, H., Brown, B., Davies, M., Dean, R. (2003). Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes. Formation of modified and oxidized particles. The FEBS Journal, 270(17), 3572-3582.
  • Hawkins, C., Pattison, D., Davies, M. (2003). Hypochlorite-induced oxidation of amino acids, peptides and proteins. Amino Acids, 25(3-4), 259-274. [More Information]
  • Rees, M., Hawkins, C., Davies, M. (2003). Hypochlorite-Mediated Fragmentation of Hyaluronan, Chondroitin Sulfates, and Related N-Acetyl Glycosamines: Evidence for Chloramide Intermediates, Free Radical Transfer Reactions, and Site-Specific Fragmentation. Journal of the American Chemical Society, 125(45), 13719-13733.
  • Pattison, D., Hawkins, C., Davies, M. (2003). Hypochlorous Acid-Mediated Oxidation of Lipid Components and Antioxidants Present in Low- Density Lipoproteins: Absolute Rate Constants, Product Analysis, and Computational Modeling. Chemical Research in Toxicology, 16(4), 439-449.
  • Wright, A., Hawkins, C., Davies, M. (2003). Photo-oxidation of cells generates long-lived intracellular protein peroxides. Free Radical Biology and Medicine, 34(6), 637-647.
  • Hagerman, A., Dean, R., Davies, M. (2003). Radical chemistry of epigallocatechin gallate and its relevance to protein damage. Archives of Biochemistry and Biophysics, 414(1), 115-120.
  • Belli, S., Wallach, M., Luxford, C., Davies, M., Smith, N. (2003). Roles of tyrosine-rich precursor glycoproteins and dityrosine- and 3,4-dihydroxyphenylalanine-mediated protein cross-linking in development of the Oocyst wall in the Coccidian parasite Eimeria maxima. Eukaryotic Cell, 2(3), 456-464.
  • Davies, M. (2003). Singlet oxygen-mediated damage to proteins and its consequences. Biochemical and Biophysical Research Communications, 305(3), 761-770.
  • van Reyk, D., Gillies, M., Davies, M. (2003). The retina: oxidative stress and diabetes. Redox Report, 8(4), 187-192.
  • Hawkins, C., Pattison, D., Davies, M. (2002). Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation. Biochemical Journal, 365(3), 605-615.
  • Wright, A., Bubb, W., Hawkins, C., Davies, M. (2002). Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues. Photochemistry and Photobiology, 76(1), 35-46.
  • Hawkins, C., Rees, M., Davies, M. (2002). Superoxide radicals can act synergistically with hypochlorite to induce damage to proteins. FEBS Letters, 510(1-2), 41-44.
  • Hawkins, C., Davies, M. (2001). Generation and propagation of radical reactions on proteins. BBA - Bioenergetics, 1504 (2-3), 196-219.
  • Hawkins, C., Brown, B., Davies, M. (2001). Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis. Archives of Biochemistry and Biophysics, 395, 137-145.
  • Hawkins, C., Davies, M. (2001). Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals. Chemical Research in Toxicology, 14, 1071-1081.

Conferences

  • Nobecourt, E., Puranik, R., Bao, B., Davies, M., Barter, P., Rye, K. (2006). Evidence that glycation of apolipoprotein. XIV International Symposium on Atherosclerosis, Ireland: Elsevier Ireland Ltd.
  • Pattison, D., Davies, M. (2005). Histidine side-chain chloramines are important intermediates in HOCL-mediated protein oxidation. 13th Biennial Meeting of the Society for Free Radical Research, United Kingdom: Taylor and Francis.
  • Rees, M., Davies, M. (2005). HOC1 degrades extracellular matrix heparan sulfates via the formation of N-chloro derivatives. 13th Biennial Meeting of the Society for Free Radical Research, United Kingdom: Taylor and Francis.

2014

  • Dunn, L., Simpson, P., Prosser, H., Lecce (Venuto), L., Yuen, S., Buckle, A., Sieveking, D., Vanags, L., Lim, P., Chow, R., Bao, B., Davies, M., Celermajer, D., Bursill, C., Ng, M., et al (2014). A Critical Role for Thioredoxin Interacting Protein in Diabetes-Related Impairment of Angiogenesis. Diabetes, 63(2), 675-687. [More Information]
  • Hawkins, C., Davies, M. (2014). Detection and characterisation of radicals in biological materials using EPR methodology. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1840 (2), 708-721. [More Information]
  • Gad, N., Mizdrak, J., Pattison, D., Davies, M., Truscott, R., Jamie, J. (2014). Detection, quantification, and total synthesis of novel 3-hydroxykynurenine glucoside-derived metabolites present in human lenses. Investigative Ophthalmology & Visual Science, 55(2), 849-855. [More Information]
  • Karimi Galougahi, K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N., Davies, M., Hawkins, C., Rasmussen, H., Figtree, G. (2014). Glutathionylation Mediates Angiotension II-Induced eNOS Uncoupling, Amplifying NADPH Oxidase-Dependent Endothelial Dysfunction. Journal of the American Heart Association, 3(2), 1-11. [More Information]
  • Nedoboy, P., Morgan, P., Mocatta, T., Richards, M., Winterbourn, C., Davies, M. (2014). High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction. Free Radical Research, 48(10), 1256-1266. [More Information]
  • Kajer, T., Fairfull-Smith, K., Yamasaki, T., Yamada, K., Fu, S., Bottle, S., Hawkins, C., Davies, M. (2014). Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides. Free Radical Biology and Medicine, 70, 96-105. [More Information]
  • Storkey, C., Pattison, D., Gaspard, D., Hagestuen, E., Davies, M. (2014). Mechanisms of degradation of the natural high-potency sweetener (2R,4R)-monatin in mock beverage solutions. Journal of Agricultural and Food Chemistry, 62(15), 3476-3487. [More Information]
  • Chuang, C., Degendorfer, G., Davies, M. (2014). Oxidation and modification of extracellular matrix and its role in disease. Free Radical Research, 48(9), 970-989. [More Information]
  • Chuang, C., Degendorfer, G., Hammer, A., Whitelock, J., Malle, E., Davies, M. (2014). Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells. The Biochemical Journal, 459(2), 313-322. [More Information]
  • Morgan, P., Sheahan, P., Davies, M. (2014). Perturbation of Human Coronary Artery Endothelial Cell Redox State and NADPH Generation by Methylglyoxal. PLoS One, 9(1), e86564. [More Information]
  • Storkey, C., Davies, M., Pattison, D. (2014). Reevaluation of the rate constants for the reaction of hypochlorous acid (HOCl) with cysteine, methionine, and peptide derivatives using a new competition kinetic approach. Free Radical Biology and Medicine, 73, 60-66. [More Information]
  • Brown, B., Kim, C., Torpy, F., Bursill, C., McRobb, L., Heather, A., Davies, M., van Reyk, D. (2014). Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E(-/-) mice. Atherosclerosis, 232(2), 403-409. [More Information]
  • Lord, M., Chuang, C., Melrose, J., Davies, M., Iozzo, R., Whitelock, J. (2014). The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling. Matrix Biology, 35, 112-122. [More Information]
  • Talib, J., Kwan, J., Suryo Rahmanto, A., Witting, P., Davies, M. (2014). The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction. The Biochemical Journal, 457(1), 89-97. [More Information]

2013

  • Brown, B., Nobecourt, E., Zeng, J., Jenkins, A., Rye, K., Davies, M. (2013). Apolipoprotein A-I glycation by Glucose and Reactive Aldehydes Alters Phospholipid Affinity but Not Cholesterol Export from Lipid-Laden Macrophages. PLoS One, 8(5), 1-9. [More Information]
  • Kadiiska, M., Basu, S., Brot, N., Cooper, C., Csallany, S., Davies, M., George, M., Murray, D., Roberts, J., Shigenaga, M., et al (2013). Biomarkers of oxidative stress study V: Ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine. Free Radical Biology and Medicine, 61, 408-415. [More Information]
  • Arenas, A., López-Alarcón, C., Kogan, M., Lissi, E., Davies, M., Silva, E. (2013). Chemical modification of lysozyme, glucose 6-phosphate dehydrogenase, and bovine eye lens proteins induced by peroxyl radicals: Role of oxidizable amino acid residues. Chemical Research in Toxicology, 26(1), 67-77. [More Information]
  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013). Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free Radical Biology and Medicine, 65, 1352-1362. [More Information]
  • Morgan, P., Sheahan, P., Pattison, D., Davies, M. (2013). Methylglyoxal-induced modification of arginine residues decreases the activity of NADPH-generating enzymes. Free Radical Biology and Medicine, 61, 229-242. [More Information]
  • Hadfield, K., Pattison, D., Brown, B., Hou, L., Rye, K., Davies, M., Hawkins, C. (2013). Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCI). The Biochemical Journal, 449(2), 531-542. [More Information]
  • Thorpe, G., Reodica, M., Davies, M., Heeren, G., Jarolim, S., Pillay, B., Breitenbach, M., Higgins, V., Dawes, I. (2013). Superoxide Radicals have a Protective Role during H2O2 Stress. Molecular Biology of the Cell, 24(18), 2876-2884. [More Information]
  • Thallas-Bonke, V., Coughlan, M., Tan, A., Harcourt, B., Morgan, P., Davies, M., Forbes, J., Bach, L., Cooper, M. (2013). Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content. Nephrology, 18(1), 47-56. [More Information]
  • Graham, G., Davies, M., Day, R., Mohamudally, A., Scott, K. (2013). The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology, 21(3), 201-232. [More Information]

2012

  • Karton, A., O'Reilly, R., Pattison, D., Davies, M., Radom, L. (2012). Computational design of effective, bioinspired HOCI antioxidants: The role of intramolecular C1(+) and H(+) shifts. Journal of the American Chemical Society, 134(46), 19240-19245. [More Information]
  • Davies, M. (2012). Free Radical Research origins. Free Radical Research, 46(1), 1-1. [More Information]
  • Davies, M. (2012). Free Radicals, oxidants, and protein damage. Australian Biochemist, 43(1), 8-12.
  • Talib, J., Pattison, D., Harmer, J., Celermajer, D., Davies, M. (2012). High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine. Free Radical Biology and Medicine, 53(1), 20-29. [More Information]
  • Barrett, T., Pattison, D., Leonard, S., Carroll, K., Davies, M., Hawkins, C. (2012). Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates. Free Radical Biology and Medicine, 52(6), 1075-1085. [More Information]
  • Moheimani, F., Kim, C., Rahmanto, A., van Reyk, D., Davies, M. (2012). Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: A potential contributory factor in diabetes-associated atherosclerosis. Atherosclerosis, 223(1), 144-151. [More Information]
  • Truscott, R., Mizdrak, J., Friedrich, M., Hooi, M., Lyons, B., Jamie, J., Davies, M., Wilmarth, P., David, L. (2012). Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine? Experimental Eye Research, 99(1), 48-54. [More Information]
  • Cook, N., Viola, H., Sharov, V., Hool, L., Schoeneich, C., Davies, M. (2012). Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca(2+)-ATPase activity and perturb Ca(2+) homeostasis in human coronary artery endothelial cells. Free Radical Biology and Medicine, 52(5), 951-961. [More Information]
  • Cook, N., Pattison, D., Davies, M. (2012). Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins. Free Radical Biology and Medicine, 53(11), 2072-2080. [More Information]
  • Pattison, D., Rahmanto, A., Davies, M. (2012). Photo-oxidation of proteins. Photochemical and Photobiological Sciences, 11(1), 38-53. [More Information]
  • Rahmanto, A., Pattison, D., Davies, M. (2012). Photo-oxidation-induced inactivation of the selenium-containing protective enzymes thioredoxin reductase and glutathione peroxidase. Free Radical Biology and Medicine, 53(6), 1308-1316. [More Information]
  • Storkey, C., Pattison, D., White, J., Schiesser, C., Davies, M. (2012). Preventing Protein Oxidation with Sugars: Scavenging of Hypohalous Acids by 5-Selenopyranose and 4-Selenofuranose Derivatives. Chemical Research in Toxicology, 25(11), 2589-2599. [More Information]
  • Morgan, P., Pattison, D., Davies, M. (2012). Quantification of hydroxyl radical-derived oxidation products in peptides containing glycine, alanine, valine, and proline. Free Radical Biology and Medicine, 52(2), 328-339. [More Information]
  • Pattison, D., Davies, M., Hawkins, C. (2012). Reactions and reactivity of myeloperoxidase-derived oxidants: Differential biological effects of hypochlorous and hypothiocyanous acids. Free Radical Research, 46(8), 975-995. [More Information]
  • Stadler, N., Heeneman, S., Voo, S., Stanley, N., Giles, G., Gang, B., Croft, K., Mori, T., Vacata, V., Daemen, M., Davies, M., et al (2012). Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus. Atherosclerosis, 222(2), 512-518. [More Information]
  • Skaff, O., Pattison, D., Morgan, P., Bachana, R., Jain, V., Priyadarsini, I., Davies, M. (2012). Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage. The Biochemical Journal, 441(1), 305-316. [More Information]
  • Rahmanto, A., Davies, M. (2012). Selenium-containing Amino Acids as Direct and Indirect Antioxidants. IUBMB Life, 64(11), 863-871. [More Information]
  • Pattison, D., Lam, M., Shinde, S., Anderson, R., Davies, M. (2012). The nitroxide TEMPO is an efficient scavenger of protein radicals: Cellular and kinetic studies. Free Radical Biology and Medicine, 53, 1664-1674. [More Information]

2011

  • Gracanin, M., Lam, M., Morgan, P., Rodgers, K., Hawkins, C., Davies, M. (2011). Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome. Free Radical Biology and Medicine, 50(2), 389-399. [More Information]
  • Suryo Rahmanto, A., Davies, M. (2011). Catalytic activity of selenomethionine in removing amino acid, peptide, and protein hydroperoxides. Free Radical Biology and Medicine, 51(12), 2288-2299. [More Information]
  • Dalsgaard, T., Nielsen, J., Brown, B., Stadler, N., Davies, M. (2011). Dityrosine, 3,4-dihydroxyphenylalanine (DOPA), and radical formation from tyrosine residues on milk proteins with globular and flexible structures as a result of riboflavin-mediated photo-oxidation. Journal of Agricultural and Food Chemistry, 59(14), 7939-7947. [More Information]
  • Moheimani, F., Tan, J., Brown, B., Heather, A., van Reyk, D., Davies, M. (2011). Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins. Experimental Diabetes Research, 2011 (Article ID 851280), 851280-1-851280-10. [More Information]
  • Morgan, P., Pattison, D., Talib, J., Summers, F., Harmer, J., Celermajer, D., Hawkins, C., Davies, M. (2011). High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. Free Radical Biology and Medicine, 51(9), 1815-1822. [More Information]
  • Kennett, E., Chuang, C., Degendorfer, G., Whitelock, J., Davies, M. (2011). Mechanisms and consequences of oxidative damage to extracellular matrix. Biochemical Society Transactions, 39(5), 1279-1287. [More Information]
  • Davies, M. (2011). Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. Journal of Clinical Biochemistry and Nutrition, 48(1), 8-19. [More Information]
  • Pattison, D., O'Reilly, R., Skaff, O., Radom, L., Anderson, R., Davies, M. (2011). One-electron Reduction of N-chlorinated and N-Brominated Species Is a Source of Radicals and Bromine Atom Formation. Chemical Research in Toxicology, 24(3), 371-382. [More Information]
  • Mai, K., Smith, N., Feng, Z., Katrib, M., Slapeta, J., Slapetova, I., Wallach, M., Luxford, C., Davies, M., Zhang, X., et al (2011). Peroxidase catalysed cross-linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima. International Journal for Parasitology, 41(11), 1157-1164. [More Information]
  • Storkey, C., Davies, M., White, J., Schiesser, C. (2011). Synthesis and antioxidant capacity of 5-selenopyranose derivatives. Chemical Communications, 47(34), 9693-9695. [More Information]

2010

  • Koelsch, M., Mallak, R., Graham, G., Kajer, T., Milligan, M., Nguyen, L., Newsham, D., Keh, J., Kettle, A., Scott, K., Pattison, D., Hawkins, C., Davies, M., et al (2010). Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. Biochemical Pharmacology, 79(8), 1156-1164. [More Information]
  • Suryo Rahmanto, A., Morgan, P., Hawkins, C., Davies, M. (2010). Cellular effects of peptide and protein hydroperoxides. Free Radical Biology and Medicine, 48(8), 1071-1078. [More Information]
  • Rahmanto, A., Morgan, P., Hawkins, C., Davies, M. (2010). Cellular effects of photo-generated oxidants and long-lived, reactive, hydroperoxide photoproducts. Free Radical Biology and Medicine, 49(10), 1505-1515. [More Information]
  • Moheimani, F., Morgan, P., van Reyk, D., Davies, M. (2010). Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: Possible links between diabetes and atherosclerosis. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1802 (6), 561-571. [More Information]
  • Sourris, K., Harcourt, B., Penfold, S., Yap, F., Morley, A., Morgan, P., Davies, M., Baker, S., Jerums, G., Forbes, J. (2010). Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy. Experimental Diabetes Research, 210(974681), 1-9. [More Information]
  • Rees, M., Whitelock, J., Malle, E., Chuang, C., Iozzo, R., Nilasaroya, A., Davies, M. (2010). Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan. Matrix biology: journal of the International Society for Matrix Biology, 29(1), 63-73. [More Information]
  • Nobecourt, E., Tabet, F., Lambert, G., Puranik, R., Bao, B., Yan, L., Davies, M., Brown, B., Jenkins, A., Dusting, G., Barter, P., Rye, K., et al (2010). Nonenzymatic Glycation Impairs the Antiinflammatory Properties of Apolipoprotein A-I. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), 766-772. [More Information]
  • Kennett, E., Rees, M., Malle, E., Hammer, A., Whitelock, J., Davies, M. (2010). Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains. Free Radical Biology and Medicine, 49(2), 282-293. [More Information]
  • Peskin, A., Cox, A., Nagy, P., Morgan, P., Hampton, M., Davies, M., Winterbourn, C. (2010). Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochemical Journal, 432(2), 313-321. [More Information]
  • Szuchman-Sapir, A., Pattison, D., Davies, M., Witting, P. (2010). Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b(5)-mediated heme reduction. Free Radical Biology and Medicine, 48(1), 35-46. [More Information]
  • Lane, A., Tan, J., Hawkins, C., Heather, A., Davies, M. (2010). The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. Biochemical Journal, 430(1), 161-169. [More Information]

2009

  • Davies, M. (2009). Electron parametric resonance detection of radicals in biology and medicine. In Marina Brustolon, Elio Giamello (Eds.), Electron Paramagnetic Resonance: A Practitioners Toolkit, (pp. 427-450). United States: John Wiley & Sons.
  • Morgan, P., Sturgess, A., Davies, M. (2009). Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients. Free Radical Research, 43(2), 117-127. [More Information]
  • Kennett, E., Davies, M. (2009). Glycosaminoglycans are fragmented by hydroxyl, carbonate, and nitrogen dioxide radicals in a site-selective manner: implications for peroxynitrite-mediated damage at sites of inflammation. Free Radical Biology and Medicine, 47(4), 389-400. [More Information]
  • Chapman, A., Skaff, O., Senthilmohan, R., Kettle, A., Davies, M. (2009). Hypobromous acid and bromamine production by neutrophils and modulation by superoxide. Biochemical Journal, 417(3), 773-781. [More Information]
  • Skaff, O., Pattison, D., Davies, M. (2009). Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance. Biochemical Journal, 422(1), 111-117. [More Information]
  • Rees, M., Bottle, S., Fairfull-Smith, K., Malle, E., Whitelock, J., Davies, M. (2009). Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides. Biochemical Journal, 421(1), 79-86. [More Information]
  • Hawkins, C., Morgan, P., Davies, M. (2009). Quantification of protein modification by oxidants. Free Radical Biology and Medicine, 46(8), 965-988. [More Information]
  • Gracanin, M., Hawkins, C., Pattison, D., Davies, M. (2009). Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products. Free Radical Biology and Medicine, 47(1), 92-102. [More Information]
  • Pattison, D., Hawkins, C., Davies, M. (2009). What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach. Chemical Research in Toxicology, 22(5), 807-817. [More Information]

2008

  • Stadler, N., Stanley, N., Heeneman, S., Vacata, V., Daemen, M., Bannon, P., Waltenberger, J., Davies, M. (2008). Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5), 1024-1030. [More Information]
  • Kennett, E., Davies, M. (2008). Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid. Free Radical Biology and Medicine, 45, 716-725. [More Information]
  • Nobécourt, E., Zeng, J., Davies, M., Bronwyn, B., Yadav, S., Barter, P., Rye, K. (2008). Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I. Diabetologia: clinical and experimental diabetes and metabolism, 51(6), 1008-1017. [More Information]
  • Davies, M., Murphy, D., Gilbert, B. (2008). Electron Paramagnetic Resonance. United Kingdom: Royal Society of Chemistry.
  • Szuchman-Sapir, A., Pattison, D., Ellis, N., Hawkins, C., Davies, M., Witting, P. (2008). Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin. Free Radical Biology and Medicine, 45(6), 789-798. [More Information]
  • Lloyd, M., van Reyk, D., Davies, M., Hawkins, C. (2008). Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid. Biochemical Journal, 414(2), 271-280. [More Information]
  • Summers, F., Morgan, P., Davies, M., Hawkins, C. (2008). Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines. Chemical Research in Toxicology, 21(9), 1832-1840. [More Information]
  • Davies, M., Hawkins, C., Pattison, D., Rees, M. (2008). Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxidants & Redox Signaling, 10(7), 1199-1234. [More Information]
  • Lam, M., Pattison, D., Bottle, S., Keddie, D., Davies, M. (2008). Nitric Oxide and Nitroxides Can Act as Efficient Scavengers of Protein-Derived Free Radicals. Chemical Research in Toxicology, 21(11), 2111-2119. [More Information]
  • Lund, M., Luxford, C., Skibsted, L., Davies, M. (2008). Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links. Biochemical Journal, 410(Part 3), 565-574.
  • Rees, M., Kennett, E., Whitelock, J., Davies, M. (2008). Oxidative damage to extracellular matrix and its role in human pathologies. Free Radical Biology and Medicine, 44(12), 1973-2001. [More Information]
  • Morgan, P., Pattison, D., Hawkins, C., Davies, M. (2008). Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins. Free Radical Biology and Medicine, 45(9), 1279-1289. [More Information]
  • O'Brien, P., Davies, M., Scurry, J., Smith, A., Barton, C., Henderson, M., Saunders, D., Gloss, B., Patterson, K., et, A., Murali, R., Scolyer, R., Scurr, L., deFazio, A. (2008). The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro. British Journal of Cancer, 98(6), 1085-1093. [More Information]
  • Skaff, O., Pattison, D., Davies, M. (2008). The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study. Biochemistry, 47(31), 8237-8245. [More Information]
  • Hawkins, C., Pattison, D., Stanley, N., Davies, M. (2008). Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation. Biochemical Journal, 416(3), 441-452. [More Information]

2007

  • Rashid, I., van Reyk, D., Davies, M. (2007). Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro. FEBS Letters, 581, 1067-1070. [More Information]
  • Hawkins, C., Pattison, D., Whiteman, M., Davies, M. (2007). Chlorination and nitration of DNA and nucleic acid components. In Evans M; Cooke M (Eds.), Oxidative Damage to Nucleic Acids, (pp. 14-39). United States: Springer.
  • Rees, M., McNiven, T., Davies, M. (2007). Degradation of extracellular matrix and its components by hypobromous acid. Biochemical Journal, 401(2), 587-596. [More Information]
  • Kennett, E., Davies, M. (2007). Degradation of matrix glycosaminoglycans by peroxynitrite/peroxynitrous acid: evidence for a hydroxyl-radical-like mechanism. Free Radical Biology and Medicine, 42, 1278-1289. [More Information]
  • Brown, B., Rashid, I., van Reyk, D., Davies, M. (2007). Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages. The FEBS Journal, 274, 1530-1541. [More Information]
  • Pattison, D., Hawkins, C., Davies, M. (2007). Hypochlorous Acid-Mediated Protein Oxidation: How Important Are Chloramine Transfer Reactions and Protein Tertiary Structure? Biochemistry, 46(34), 9853-9864. [More Information]
  • Gracanin, M., Davies, M. (2007). Inhibition of protein tyrosine phosphatases by amino acid, peptide, and protein hydroperoxides: potential modulation of cell signaling by protein oxidation products. Free Radical Biology and Medicine, 42, 1543-1551. [More Information]
  • Skaff, O., Pattison, D., Davies, M. (2007). Kinetics of hypobromous acid-mediated oxidation of lipid components and antioxidants. Chemical Research in Toxicology, 20(12), 1980-1988. [More Information]
  • Mizdrak, J., Hains, P., Kalinowski, D., Truscott, R., Davies, M., Jamie, J. (2007). Novel human lens metabolites from normal and cataractous human lenses. Tetrahedron, 63(23), 4990-4999.
  • Dremina, E., Sharov, V., Davies, M., Schoeneich, C. (2007). Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides. Chemical Research in Toxicology, 20(10), 1462-1469. [More Information]
  • Parker, N., Korlimbinis, A., Jamie, J., Davies, M., Truscott, R. (2007). Reversible binding of kynurenine to lens proteins: potential protection by glutathione in young lenses. Investigative Ophthalmology and Visual Science, 48(8), 3705-3713. [More Information]
  • Morgan, P., Sturgess, A., Hennessy, A., Davies, M. (2007). Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis. Free Radical Research, 41(12), 1301-1312. [More Information]
  • Nobecourt, E., Davies, M., Brown, B., Curtiss, L., Bonnet, D., Charlton, F., Januszewski, A., Jenkins, A., Barter, P., Rye, K. (2007). The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin:cholesterol acyltransferase. Diabetologia: clinical and experimental diabetes and metabolism, 50(3), 643-653. [More Information]
  • Mizdrak, J., Hains, P., Truscott, R., Jamie, J., Davies, M. (2007). Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage. Free Radical Biology and Medicine, 44(6), 1108-1119. [More Information]

2006

  • Puranik, R., Nobecourt, E., Bao, B., Davies, M., Barter, P., Celermajer, D., Rye, K. (2006). Abstract 1355: The Impact of Glycation on the Anti-inflammatory Properties of High Density Lipoproteins in vivo. Circulation, 114, II-257-II-258.
  • Pattison, D., Davies, M. (2006). Actions of ultraviolet light on cellular structures. EXS, 96, 131-157. [More Information]
  • Stanley, N., Stadler, N., Woods, A., Bannon, P., Davies, M. (2006). Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions. Free Radical Biology and Medicine, 40(9), 1636-1643. [More Information]
  • Agon, V., Bubb, W., Wright, A., Hawkins, C., Davies, M. (2006). Corrigendum to “Sensitizer-mediated photo-oxidation of histidine residues: Evidence for the formation of reactive side-chain peroxides�? Free Radical Biology and Medicine, 40(12), 2242-2242. [More Information]
  • Wood, G., Easton, C., Rauk, A., Davies, M., Radom, L. (2006). Effect of side chains on competing pathways for beta-scission reactions of peptide-backbone alkoxyl radicals. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 110(34), 10316-10323. [More Information]
  • Zeng, J., DUNLOP, R., Rodgers, K., Davies, M. (2006). Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols. Biochemical Journal, 398(2), 197-206. [More Information]
  • Pattison, D., Davies, M. (2006). Evidence for rapid inter- and intramolecular chlorine transfer reactions of histamine and carnosine chloramines: implications for the prevention of hypochlorous-Acid-mediated damage. Biochemistry, 45(26), 8152-8162. [More Information]
  • Nobecourt, E., Puranik, R., Bao, B., Davies, M., Barter, P., Rye, K. (2006). Evidence that glycation of apolipoprotein. XIV International Symposium on Atherosclerosis, Ireland: Elsevier Ireland Ltd.
  • Nobecourt, E., Puranik, R., Bao, B., Davies, M., Barter, P., Rye, K. (2006). Evidence that glycation of apolipoprotein A-I inhibits the anti-inflammatory properties of HDL in vivo. Atherosclerosis Supplements, 7, 71.
  • Rees, M., Davies, M. (2006). Heparan sulfate degradation via reductive homolysis of its N-chloro derivatives. Journal of the American Chemical Society, 128(9), 3085-3097. [More Information]
  • Brown, B., Mahroof, F., Cook, N., van Reyk, D., Davies, M. (2006). Hydrazine compounds inhibit glycation of low-density lipoproteins and prevent the in vitro formation of model foam cells from glycolaldehyde-modified low-density lipoproteins. Diabetologia: clinical and experimental diabetes and metabolism, 49(4), 775-783. [More Information]
  • Headlam, H., Gracanin, M., Rodgers, K., Davies, M. (2006). Inhibition of cathepsins and related proteases by amino acid, peptide, and protein hydroperoxides. Free Radical Biology and Medicine, 40(9), 1539-1548. [More Information]
  • Malle, E., Marsche, G., Arnhold, J., Davies, M. (2006). Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. [More Information]
  • Zeng, J., Davies, M. (2006). Protein and low molecular mass thiols as targets and inhibitors of glycation reactions. Chemical Research in Toxicology, 19(12), 1668-1676. [More Information]
  • Pattison, D., Davies, M. (2006). Reactions of myeloperoxidase-derived oxidants with biological substrates: gaining chemical insight into human inflammatory diseases. Current Medicinal Chemistry, 13(27), 3271-3290. [More Information]
  • Moran, D., Jacob, R., Wood, G., Coote, M., Davies, M., O'Hair, R., Easton, C., Radom, L. (2006). Rearrangements in model peptide-type radicals via intramolecular hydrogen-atom transfer. Helvetica Chimica Acta, 89(10), 2254-2272.
  • Agon, V., Bubb, W., Wright, A., Hawkins, C., Davies, M. (2006). Sensitizer-mediated photooxidation of histidine residues: evidence for the formation of reactive side-chain peroxides. Free Radical Biology and Medicine, 40(4 to 5), 698-710. [More Information]
  • Davies, M., Brown, B., Imran, R., van Reyk, D. (2006). The roles of protein glycation, glycoxidation and advanced glycation end-product formation in diabetes-induced atherosclerosis. In Sukhinder C. Kaur Cheema (Eds.), Biochemistry of Atherosclerosis (Advances in Biochemistry in Health and Disease), (pp. 247-283). United States: Springer Science + Business Media.

2005

  • Rees, M., Davies, M. (2005). EPR studies of spin trap adducts of carbohydrate radicals: recognition of adduct isomerism and chirality. Current Topics in Biophysics, 29, 11-24.
  • Zeng, J., Davies, M. (2005). Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins. Chemical Research in Toxicology, 18(8), 1232-1241. [More Information]
  • Brown, B., Dean, R., Davies, M. (2005). Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells. Diabetologia: clinical and experimental diabetes and metabolism, 48(2), 361-369. [More Information]
  • Furukawa, A., Hiraku, Y., Oikawa, S., Luxford, C., Davies, M., Kawanishi, S. (2005). Guanine-specific DNA damage induced by gamma-irradiated histone. Biochemical Journal, 388(Part 3), 813-818.
  • Pattison, D., Davies, M. (2005). Histidine side-chain chloramines are important intermediates in HOCL-mediated protein oxidation. 13th Biennial Meeting of the Society for Free Radical Research, United Kingdom: Taylor and Francis.
  • Rees, M., Davies, M. (2005). HOC1 degrades extracellular matrix heparan sulfates via the formation of N-chloro derivatives. 13th Biennial Meeting of the Society for Free Radical Research, United Kingdom: Taylor and Francis.
  • Hawkins, C., Davies, M. (2005). Inactivation of protease inhibitors and lysozyme by hypochlorous acid: role of side-chain oxidation and protein unfolding in loss of biological function. Chemical Research in Toxicology, 18(10), 1600-1610.
  • Morgan, P., Sturgess, A., Davies, M. (2005). Increased Levels of Serum Protein Oxidation and Correlation With Disease Activity in Systemic Lupus Erythematosus. Arthritis and Rheumatism, 52(7), 2069-2079. [More Information]
  • Pattison, D., Davies, M. (2005). Kinetic analysis of the role of histidine chloramines in hypochlorous acid mediated protein oxidation. Biochemistry, 44(19), 7378-7387. [More Information]
  • Birinyi-Strachan, L., Davies, M., Lewis, R., Nicholson, G. (2005). Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: a comparison with other osmotic agents and free radical scavengers. Neuropharmacology, 49(5), 669-686. [More Information]
  • Rees, M., Pattison, D., Davies, M. (2005). Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation. Biochemical Journal, 391(Pt 1), 125-134. [More Information]
  • Sheil, M., Luxford, C., Davies, M., Peat, J., Nunn, G., Celermajer, D. (2005). Protein oxidation injury occurs during pediatric cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery, 130(4), 1054-1061. [More Information]
  • Davies, M. (2005). The oxidative environment and protein damage. BBA - Bioenergetics, 1703 (2), 93-109. [More Information]
  • Hawkins, C., Davies, M. (2005). The Role of Aromatic Amino Acid Oxidation, Protein Unfolding, and Aggregation in the Hypobromous Acid-Induced Inactivation of Trypsin Inhibitor and Lysozyme. Chemical Research in Toxicology, 18(11), 1669-1677. [More Information]
  • Hawkins, C., Davies, M. (2005). The role of reactive N-bromo species and radical intermediates in hypobromous acid-induced protein oxidation. Free Radical Biology and Medicine. [More Information]

2004

  • Stadler, N., Lindner, R., Davies, M. (2004). Direct Detection And Quantification Of Transition Metal Ions In Human Atherosclerotic Plaques: Evidence For The Presence Of Elevated Levels Of Iron And Copper. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(5), 949-954.
  • Davies, M., Hawkins, C. (2004). EPR spin trapping of protein radicals. Free Radical Biology and Medicine, 36(9), 1072-1086. [More Information]
  • Rees, M., Hawkins, C., Davies, M. (2004). Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates. Biochemical Journal, 381(1), 175-184.
  • Pattison, D., Davies, M. (2004). Kinetic Analysis Of The Reactions Of Hypobromous Acid With Protein Components: Implications For Cellular Damage And Use Of 3-Bromotyrosine As A Marker Of Oxidative Stress. Biochemistry, 43(16), 4799-4809.
  • Headlam, H., Davies, M. (2004). Markers Of Protein Oxidation: Different Oxidants Give Rise To Variable Yields Of Bound And Released Carbonyl Products. Free Radical Biology and Medicine, 36(12), 1175-1184. [More Information]
  • Heinzelmann-Schwarz, V., Gardiner-Garden, M., Henshall, S., Scurry, J., Scolyer, R., Davies, M., Heinzelmann, M., Kalish, L., Bali, A., Kench, J., et al (2004). Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. Clinical Cancer Research, 10(13), 4427-4436. [More Information]
  • Morgan, P., Dean, R., Davies, M. (2004). Protective Mechanisms Against Peptide And Protein Peroxides Generated By Singlet Oxygen. Free Radical Biology and Medicine, 36(4), 484-496. [More Information]
  • Parker, N., Jamie, J., Davies, M., Truscott, R. (2004). Protein-Bound Kynurenine Is A Photosensitizer Of Oxidative Damage. Free Radical Biology and Medicine, 37(9), 1479-1489. [More Information]
  • Davies, M. (2004). Reactive Species Formed On Proteins Exposed To Singlet Oxygen. Photochemical and Photobiological Sciences, 3(1), 17-25.
  • Winterbourn, C., Parsons-Mair, H., Gebicki, S., Gebicki, J., Davies, M. (2004). Requirements For Superoxide-Dependent Tyrosine Hydroperoxide Formation In Peptides. Biochemical Journal, 381(Part 1), 241-248.

2003

  • Headlam, H., Davies, M. (2003). Cell-mediated reduction of protein and peptide hydroperoxides to reactive free radicals. Free Radical Biology and Medicine, 34(1), 44-55.
  • Woods, A., Linton, S., Davies, M. (2003). Detection of HOCI- mediated protein oxidation in the extracellular matrix of human atherosclerotic plaques. Biochemical Journal, 370(2), 729-735.
  • Clancy, J., Henderson, M., Russell, A., Anderson, D., Bova, R., Campbell, I., Choong, D., Macdonald, G., Mann, G., Nolan, T., Davies, M., et al (2003). EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. Oncogene, 22(32), 5070-5081. [More Information]
  • Woods, A., Davies, M. (2003). Fragmentation of extracellular matrix by hypochlorous acid. Biochemical Journal, 376(1), 219-227.
  • Knott, H., Brown, B., Davies, M., Dean, R. (2003). Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes. Formation of modified and oxidized particles. The FEBS Journal, 270(17), 3572-3582.
  • Hawkins, C., Pattison, D., Davies, M. (2003). Hypochlorite-induced oxidation of amino acids, peptides and proteins. Amino Acids, 25(3-4), 259-274. [More Information]
  • Rees, M., Hawkins, C., Davies, M. (2003). Hypochlorite-Mediated Fragmentation of Hyaluronan, Chondroitin Sulfates, and Related N-Acetyl Glycosamines: Evidence for Chloramide Intermediates, Free Radical Transfer Reactions, and Site-Specific Fragmentation. Journal of the American Chemical Society, 125(45), 13719-13733.
  • Pattison, D., Hawkins, C., Davies, M. (2003). Hypochlorous Acid-Mediated Oxidation of Lipid Components and Antioxidants Present in Low- Density Lipoproteins: Absolute Rate Constants, Product Analysis, and Computational Modeling. Chemical Research in Toxicology, 16(4), 439-449.
  • Wright, A., Hawkins, C., Davies, M. (2003). Photo-oxidation of cells generates long-lived intracellular protein peroxides. Free Radical Biology and Medicine, 34(6), 637-647.
  • Hagerman, A., Dean, R., Davies, M. (2003). Radical chemistry of epigallocatechin gallate and its relevance to protein damage. Archives of Biochemistry and Biophysics, 414(1), 115-120.
  • Belli, S., Wallach, M., Luxford, C., Davies, M., Smith, N. (2003). Roles of tyrosine-rich precursor glycoproteins and dityrosine- and 3,4-dihydroxyphenylalanine-mediated protein cross-linking in development of the Oocyst wall in the Coccidian parasite Eimeria maxima. Eukaryotic Cell, 2(3), 456-464.
  • Davies, M. (2003). Singlet oxygen-mediated damage to proteins and its consequences. Biochemical and Biophysical Research Communications, 305(3), 761-770.
  • van Reyk, D., Gillies, M., Davies, M. (2003). The retina: oxidative stress and diabetes. Redox Report, 8(4), 187-192.

2002

  • Hawkins, C., Pattison, D., Davies, M. (2002). Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation. Biochemical Journal, 365(3), 605-615.
  • Wright, A., Bubb, W., Hawkins, C., Davies, M. (2002). Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues. Photochemistry and Photobiology, 76(1), 35-46.
  • Hawkins, C., Rees, M., Davies, M. (2002). Superoxide radicals can act synergistically with hypochlorite to induce damage to proteins. FEBS Letters, 510(1-2), 41-44.

2001

  • Hawkins, C., Davies, M. (2001). Generation and propagation of radical reactions on proteins. BBA - Bioenergetics, 1504 (2-3), 196-219.
  • Hawkins, C., Brown, B., Davies, M. (2001). Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis. Archives of Biochemistry and Biophysics, 395, 137-145.
  • Hawkins, C., Davies, M. (2001). Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals. Chemical Research in Toxicology, 14, 1071-1081.

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