Professor Macdonald Christie

Professor of Pharmacology, School of Medical Sciences
Associate Dean (Research), Sydney Medical School
NHMRC Senior Principal Research Fellow

Telephone +61 2 9351 2946

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Biographical details

Professor Macdonald (Mac) Christie is a neuropharmacologist, an internationally renowned electrophysiologist and expert in ion channel and synaptic physiology and pharmacology and the leading basic opioid pharmacologist in the nation. He leads a research team that studies cellular and molecular mechanisms in opioid receptor signaling in pain pathways, the biological basis of adaptations that produce chronic pain and drug dependence, and is Chief Investigator on a NHMRC Program grant involving preclinical development of novel pain therapeutics. Professor Christie is internationally renowned for his studies on ion channel function and neural network plasticity in nervous system disorders such as chronic pain and drug dependence. His research is fundamentally important given the increasing use of opioids to manage moderate to severe chronic pain is complicated by adverse effects such as tolerance, opioid dependence and in some cases, addiction. Misuse and/or inappropriate prescription of opioids are added problems. Increasing the understanding of mechanisms involved in the generation of chronic pain and in the analgesic and adverse effects of opioids (including why/how opioids produce withdrawal symptoms), will pave the way for developing newer therapies that divert signals toward pathways that produce pain relief but with lower rates of adverse effects. Professor Christie is a past Director (Basic Research) and Professor at the Pain Management Research Institute, Royal North Shore Hospital, and Director of Pain and Addiction Research at the Brain and Mind Research Institute, University of Sydney. He is a member of the Board of Directors of the Woolcock Institute of Medical Research and of the Sydney Cancer Institute and member of the NSW Tissue Resource Centre Management Committee.

Research interests

Professor Christie’s research has heralded numerous ‘firsts’. He contributed to the first cloning of the D2 dopamine receptor (Nature) and achieved the first expression of a mammalian voltage-gated potassium channel (Science), and first functional demonstration of its heteropolymerisation (Neuron). His later research uncovered the mechanisms of plasticity of G-protein receptor coupling in neurons that are transforming thinking regarding opioid tolerance and ion channel plasticity in chronic pain states. His group discovered that µ and δ opioid receptors in nerve cells share common G-Protein receptor coupling mechanisms and provided the first evidence of direct coupling of µ-receptors to GIRK channels and of coupling of the opioid-related receptor ORL1, to GIRK channels in brain as well as in cannabinoid signaling. He discovered a novel signalling mechanism for G-Protein Coupled Receptors (GPCR) in synapses in brain (Nature). This provided a basis for seminal findings on plasticity of signaling in opioid withdrawal published in Neuron (2005) and recently in Nature Neuroscience (2011).

Currently, Professor Christie continues to study opioid receptor regulation in pain and analgesia, in particular the processes driving the development of opioid tolerance. His team is investigating the molecular mechanisms responsible for tolerance at the µ-opioid receptor, action-related learning and plasticity in the cortico-striatal network, and studying novel GPCR mechanisms to treat neural hyper-excitation in chronic pain. These studies on intracellular signal bias aim to develop novel therapeutics for pain and addiction that could potentially preferentially divert signaling toward pathways associated with increased analgesic efficacy and lower rates of tolerance and/or fewer adverse effects. Additionally, as a Chief Investigator on a NHMRC Program Grant, Professor Christie is leading collaborative research (with researchers at the University of Queensland and at RMIT) on the development and discovery of novel analgesics based on conotoxins. The research teams have discovered a number of conotoxin peptides that selectively block pain pathways without producing tolerance, which are currently being characterised further for improved pain relief in humans.

Selected grants

2016

  • Neuroplasticity in the orbitofrontal cortex underlying habits; Borgland S, Christie M; DVC Research/International Research Collaboration Award (IRCA).

2015

  • Disorders of action control and learning-related plasticity in the basal ganglia; Balleine B, Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ion channel modulators of pain pathways; Christie M; National Health and Medical Research Council (NHMRC)/Program Grants.

2014

  • Stereotaxic frame; Arnold J, Christie M, Collins M, Sawatari A, Leamey C, Stone J, van Nieuwenhuijzen P, Chan-Ling T, Balle T; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • BioMark HD High-throughput Real Time & Digital PCR System for the Open Access, Multi-Disciplinary Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Lee C, Halliday G, Murray M, Lay P, Christie M, Kench J, Damian D, Hersey P; Cancer Institute New South Wales/Equipment Grant.
  • Sydney Neuroscience Network; Balleine B, Absalom N, Braddon-Mitchell D, Callaghan S, Chawla S, Christie M, Collins M, Einfeld S, Grieve S, Haber P, Hanrahan J, Harris A, Hickie I, Kassiou M, Kril J, Meikle S, Morris R, Ramos F, Rong Y, Sue C; DVC Research/Research Network Scheme (SyReNS).
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Novel GPCR mechanisms to treat neural hyper-excitation in chronic pain.; Imlach W, Imlach W, Christie M; DVC Research/Postdoctoral Research Fellowship Scheme.
  • Mouse behavioural phenotyping battery; Hunt N, Christie M, McGregor I, Kassiou M, Collins M, Stone J, Arnold J, Sawatari A, Mitrofanis J, Camp A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Developing novel neuroreceptor and channel therapies for pain and addiction; Christie M; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.

2011

  • The mechanisms responsible for tolerance at the mu-opioid receptor; Christie M, Connor M, Chieng B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Action-related learning and plasticity in the cortico-striatal network; Balleine B, Christie M; Australian Research Council (ARC)/Discovery Projects (DP).

2010

  • Venom peptide modulators of pain pathways; Lewis R, Alewood P, Lewis R, Dua U, Adams D, Alewood P, Adams D, Christie M; National Health and Medical Research Council (NHMRC)/Program Grants.

2008

  • Career Awards: Research Fellowship; Christie M; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • Anandamide activated chloride channels in sensory neurons; Connor M, Christie M; Australian Research Council (ARC)/Discovery Projects (DP).
  • Role of GAT-1 transporter channels in opioid dependence; Christie M, Chieng B, Bagley E; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Research Infrastructure (Major Equipment) Scheme 2008; Ittner L, Goetz J, Christie M, Bennett M, Kassiou M, Connor M, Holsinger D, Bagley E; Faculty of Medicine/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Real-time cellular imaging system; Connor M, Keast J, Vaughan C, Christie M, Osborne P, Bagley E, Sue C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • Stimulus induced synaptic plasticity in the amygdala.; Bagley E, Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • The assessment of anti-hyperalgesic and anti-inflammatory properties of Xen0458; Christie M, Palant E; Ultraceuticals Pty Ltd/Research Grants.

2005

  • Dissecting Pain Pathways With Conopeptides; Lewis R, Alewood P, Adams D, Alewood P, Adams D, Christie M; National Health and Medical Research Council (NHMRC)/Program Grants.
  • FACS Aria for the University of Sydney Flow Cytometry Facility; King N, Pollard J, Rasko J, Lovicu F, Bishop A, Bertolino P, Briscoe H, Gillies M, Madigan M, McAvoy J, Murphy C, Balcar V, Armour C, Hughes M, Reeve V, Christopherson R, Halliday G, Christie M, Pollock C, McCaughan G, Gorrell M, Dong Q, Abendroth A, Menzies S, Barnetson R, Byrne S, Hunt N, Hambly B, Cook D, Mason R, Day M, Black J; University of Sydney/Equipment Grant.
  • Pain following spinal cord injury: understanding mechanisms to develop treatments.; Keast J, Siddall P, Cousins M, Osborne P, Christie M; NSW Ministry of Science and Medical Research/Spinal Cord Injury Research Grants.
  • The Role Of Ascending Nociceptive Neurons In Pain Processing; Siddall P, Christie M; ANZ Coll Anaesthetists (ANZCA)/Research Funding Scheme.

2004

  • Novel delta receptror expression in opioid tolerant/dependent neurons; Christie M, Chieng B; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Olympus FV300 confocal system plus assessories; Christie M, Vaughan C, Connor M, Keay K; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Translation of novel G-protein-coupled receptor functions into new drug mechanisms; Christie M; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.
  • Concentration - response curve on VR1 channel currents in mouse trigeminal ganglion neurons : ZingoTX Pty Ltd; Christie M, White J, Chambers N; ZingoTX Pty Limited/Research Grants.

2002

  • The digital restoration of the Dublin Kephalaia codex and its importance for the history of religions; Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms of opioid receptor desensitisation in single neurons; Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Modulation of cloned potassium channels expressed in mammalian cells; Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Opoid withdrawal mechanisms in midbrain neurons; Christie M; National Institutes of Health (USA)/Research Grant.

2000

  • Brainstem circuits in opiate analgesia; Christie M; National Institutes of Health (USA)/Research Grant.
  • Insecticidal neurotoxins from Australian funnel web spiders: novel leads for insecticide design; Christie M, King G; Australian Research Council (ARC)/Large Research Grants (LRG).
  • Cellular mechanisms of opioid tolerance and physical dependence; Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Synergism between opioids and other agents at central primary afferent synapses; Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Cellular mechanism of opioid physical dependence; Vaughan C, Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Christie, M. (2015). Opioids and their signalling mechanisms at opioid receptors. In Patricia Armati, Roberta Chow (Eds.), Pain: The person, the science, the clinical interface, (pp. 205-220). Melbourne: IP Communications.
  • Vaughan, C., Christie, M. (2005). Mechanisms of cannabinoid analgesia. Cannabis and Cannabinoids: Pharmacology, Toxicology and Therapeutic Potential, (pp. 89-100). UK: Harworth Press.
  • Vaughan, C., Christie, M. (2005). Retrograde signalling by endocannabinoids. In Pertwee R (Eds.), Handbook of Experimental Pharmacology, (pp. 367-384). Heidelberg: Springer.
  • Christie, M., Vaughan, C. (2004). Mechanismen Der Cannabinoidanalgesie. In Franjo Grotenhermen (Eds.), Cannabis und Cannabinoide, (pp. 115-125). Bern: Nicholson Museum, University of Sydney.
  • Vaughan, C., Christie, M. (2002). Mechanisms of Cannabinoid Analgesia. In Grotenhermen, F & Russo, E (Eds.), Cannibis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential, (pp. 89-99). Binghampton, NY, USA: Staempfli Publishers Ltd.
  • Vaughan, C., Christie, M. (2001). Mechanisms of cannabinoid analgesia. In Franjo Grotenhermen (Hrsg) (Eds.), Cannabis and Cannabinoide, (pp. 109-119). Germany: Academic Press.

Journals

  • Connor, M., Bagley, E., Chieng, B., Christie, M. (2015). beta-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons. British Journal of Pharmacology, 172(2), 492-500. [More Information]
  • Cox, B., Christie, M., Devi, L., Toll, L., Traynor, J. (2015). Challenges for Opioid Receptor Nomenclature: IUPHAR Review 9. British Journal of Pharmacology, 172(2), 317-323. [More Information]
  • Murali, S., Napier, I., Mohammadi, S., Alewood, P., Lewis, R., Christie, M. (2015). High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury. Journal of Neurophysiology, 113(5), 1511-1519. [More Information]
  • Christie, M., Connor, M., Traynor, J. (2015). Themed section. British Journal of Pharmacology, 172(2), 247-250. [More Information]
  • Sadeghi, M., Tzschentke, T., Christie, M. (2015). μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons. British Journal of Pharmacology, 172(2), 460-468. [More Information]
  • Mohammadi, S., Christie, M. (2014). Alpha9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia. Molecular Pain, 10(1), 1-9. [More Information]
  • Vandenberg, R., Ryan, R., Carland, J., Imlach, W., Christie, M. (2014). Glycine transport inhibitors for the treatment of pain. Trends In Pharmacological Sciences, 35(8), 423-430. [More Information]
  • Jin, A., Vetter, I., Dutertre, S., Abraham, N., Emidio, N., Inserra, M., Murali, S., Christie, M., Alewood, P., Lewis, R. (2014). MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors. Biochemistry, 53(1), 1-3. [More Information]
  • Shan, Q., Ge, M., Christie, M., Balleine, B. (2014). The acquisition of goal-directed actions generates opposing plasticity in direct and indirect pathways in dorsomedial striatum. The Journal of Neuroscience, 34(28), 9196-9201. [More Information]
  • Imlach, W., Christie, M. (2014). The light touch of delta opioid receptors. Neuron, 81(6), 1220-1222. [More Information]
  • Knapman, A., Santiago, M., Du, Y., Bennallack, P., Christie, M., Connor, M. (2013). A Continuous, Fluorescence-based Assay of u-Opioid Receptor Activation in AtT-20 Cells. Journal of Biomolecular Screening, 18(3), 269-276. [More Information]
  • Saberi, S., Du, Y., Christie, M., Goldsbury, C. (2013). Human Chorionic Gonadotropin Increases b-Cleavage of Amyloid Precursor Protein in SH-SY5Y Cells. Cellular and Molecular Neurobiology, 33(6), 747-751. [More Information]
  • Bertran-Gonzalez, J., Laurent, V., Chieng, B., Christie, M., Balleine, B. (2013). Learning-related translocation of δ-Opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions. The Journal of Neuroscience, 33(41), 16060-16071. [More Information]
  • Sadeghi, M., Murali, S., Lewis, R., Alewood, P., Mohammadi, S., Christie, M. (2013). Novel [omega]-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration. Molecular Pain, 9(1), 1-9. [More Information]
  • Williams, J., Ingram, S., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C., Christie, M. (2013). Regulation of & mu; -Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance. Pharmacological Reviews, 65(1), 223-254. [More Information]
  • Jayamanne, A., Jeong, H., Schroeder, C., Lewis, R., Christie, M., Vaughan, C. (2013). Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology, 170(2), 245-254. [More Information]
  • Brust, A., Wang, C., Daly, N., Kennerly, J., Sadeghi, M., Christie, M., Lewis, R., Mobli, M., Alewood, P. (2013). Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter. Angewandte Chemie (International Edition), 52(46), 12020-12023. [More Information]
  • Vetter, I., Mozar, C., Durek, T., Wingerd, J., Alewood, P., Christie, M., Lewis, R. (2012). Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology, 83(11), 1562-1571. [More Information]
  • Lewis, R., Dutertre, S., Vetter, I., Christie, M. (2012). Conus venom peptide pharmacology. Pharmacological Reviews, 64(2), 259-298. [More Information]
  • Napier, I., Mohammadi, S., Christie, M. (2012). Glutamate transporter dysfunction associated with nerve injury-induced pain in mice. Journal of Neurophysiology, 107(2), 649-657. [More Information]
  • Napier, I., Klimis, H., Rycroft, B., Jin, A., Alewood, P., Motin, L., Adams, D., Christie, M. (2012). Intrathecal a-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology, 62(7), 2202-2207. [More Information]
  • Dang, V., Christie, M. (2012). Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons. British Journal of Pharmacology, 165(6), 1704-1716. [More Information]
  • Graeber, M., Christie, M. (2012). Multiple mechanisms of microglia: a gatekeeper's contribution to pain states. Experimental Neurology, 234(2), 255-261. [More Information]
  • Enoksson, T., Bertran-Gonzalez, J., Christie, M. (2012). Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively. Neuropharmacology, 62(8), 2463-2471. [More Information]
  • Murali, S., Napier, I., Rycroft, B., Christie, M. (2012). Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels. The Journal of Physiology, 590(7), 1655-1667. [More Information]
  • Dang, V., Chieng, B., Christie, M. (2012). Prolonged stimulation of u-opioid receptors produces B-arrestin-2-mediated heterologous desensitization of a2-adrenoceptor function in locus ceruleus neurons. Molecular Pharmacology, 82(3), 473-480. [More Information]
  • Klimis, H., Adams, D., Callaghan, B., Nevin, S., Alewood, P., Vaughan, C., Mozar, C., Christie, M. (2011). A Novel Mechanism of Inhibition of High-Voltage Activated Calcium Channels by alpha-Conotoxins Contributes to Relief of Nerve Injury-Induced Neuropathic Pain. Pain, 152(2), 259-266. [More Information]
  • Morgan, M., Christie, M. (2011). Analysis of Opioid Efficacy, Tolerance, Addiction, and Dependence from Cell Culture to Human. British Journal of Pharmacology, 164(4), 1322-1334. [More Information]
  • Dang, V., Chieng, B., Azriel, Y., Christie, M. (2011). Cellular Morphine Tolerance Produced by {beta}Arrestin-2-Dependent Impairment of {mu}-Opioid Receptor Resensitization. The Journal of Neuroscience, 31(19), 7122-7130. [More Information]
  • Chieng, B., Azriel, Y., Mohammadi, S., Christie, M. (2011). Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area. The Journal of Physiology, 589(15), 3775-3787. [More Information]
  • Bagley, E., Hacker, J., Chefer, V., Mallet, C., McNally, G., Chieng, B., Perroud, J., Shippenberg, T., Christie, M. (2011). Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nature Neuroscience, 14(12), 1548-1554. [More Information]
  • Kawahara, H., Drew, G., Christie, M., Vaughan, C. (2011). Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey. British Journal of Pharmacology, 163(6), 1214-1222. [More Information]
  • Pedersen, N., Vaughan, C., Christie, M. (2011). Opioid receptor modulation of GABAergic and serotonergic spinally-projecting neurons of the rostral ventromedial medulla in mice. Journal of Neurophysiology, 106(2), 731-740. [More Information]
  • Christie, M., Vaughan, C. (2011). Receptors: Cannabis medicine without a high. Nature Chemical Biology. [More Information]
  • de Araujo, A., Callaghan, B., Nevin, S., Daly, N., Craik, D., Moretta, M., Hopping, G., Christie, M., Alewood, P., Adams, D. (2011). Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-assisted Folding. Angewandte Chemie (International Edition), 50(29), 6527-6529. [More Information]
  • Berecki, G., Motin, L., Haythornthwaite, A., Vink, S., Bansal, P., Drinkwater, R., Wang, C., Moretta, M., Lewis, R., Alewood, P., Christie, M., et al (2010). Analgesic omega-Conotoxins CVIE and CVIF Selectively and Voltage-Dependently Block Recombinant and Native N-Type Calcium Channels. Molecular Pharmacology, 77(2), 139-148. [More Information]
  • Morales, R., Daly, N., Vetter, I., Mobli, M., Napier, I., Craik, D., Lewis, R., Christie, M., King, G., Alewood, P., et al (2010). Chemical Synthesis and Structure of the Prokineticin Bv8. ChemBioChem: a European journal of chemical biology, 11(13), 1882-1888. [More Information]
  • Ittner, L., Ke, Y., Delerue, F., Bi, M., Gladbach, A., Van Eersel, J., Wolfing, H., Chieng, B., Christie, M., Napier, I., Goetz, J., et al (2010). Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell, 142(3), 387-397. [More Information]
  • Chieng, B., Christie, M. (2010). Somatostatin and nociceptin inhibit neurons in the central nucleus of amygdala that project to the periaqueductal grey. Neuropharmacology, 59(6), 425-430. [More Information]
  • Morgan, M., Ashley, M., Ingram, S., Christie, M. (2009). Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats. Neural Plasticity, 2009 (516328), 1-7. [More Information]
  • Chieng, B., Christie, M. (2009). Chronic morphine treatment induces functional delta-opioid receptors in amygdala neurons that project to periaqueductal grey. Neuropharmacology, 57(4), 430-437. [More Information]
  • Christie, M., Mallet, C. (2009). Endocannabinoids can open the pain gate. Science Signaling, 2(88), 57. [More Information]
  • Dang, V., Napier, I., Christie, M. (2009). Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. The Journal of Neuroscience, 29(10), 3322-3327. [More Information]
  • Christie, M. (2008). Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction. British Journal of Pharmacology, 154(2), 384-396. [More Information]
  • Chieng, B., Lee, D., Du, Y., Osborne, P., Christie, M., Massottec, D. (2008). Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells. NeuroReport, 19(18), 1793-1796. [More Information]
  • Nevin, S., Clark, R., Klimis, H., Christie, M., Craik, D., Adams, D. (2007). Are alpha 9 alpha 10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Molecular Pharmacology, 72(6), 1406-1410.
  • Nevin, S., Clark, R., Klimis, H., Christie, M., Craik, D., Adams, D. (2007). Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Molecular Pharmacology, 72(6), 1406-1410. [More Information]
  • Rycroft, B., Vikman, K., Christie, M. (2007). Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn. The Journal of Physiology, 580(3), 883-894. [More Information]
  • Vikman, K., Rycroft, B., Christie, M. (2007). Switch to Ca2+ permeable AMPA and reduced NR2B NMDA receptor mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat. The Journal of Physiology, 586(2), 515-527. [More Information]
  • Liu, X., Banister, S., Christie, M., Banati, R., Meikle, S., Coster, M., Kassiou, M. (2007). Trishomocubanes: Novel sigma ligands modulate cocaine-induced behavioural effects. European Journal of Pharmacology, 555(1), 37-42.
  • Jennings, E., Christie, M., Sessle, B. (2006). ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis. NeuroReport, 17(14), 1507-1510. [More Information]
  • Chieng, B., Christie, M., Osborne, P. (2006). Characterization of neurons in the rat central nucleus of the amygdala: Cellular physiology, morphology, and opioid sensitivity. The Journal of Comparative Neurology, 497(6), 910-927. [More Information]
  • Hacker, J., Pedersen, N., Chieng, B., Keay, K., Christie, M. (2006). Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal. Neuroscience, 137(4), 1389-1396. [More Information]
  • Zwar, N., Bell, J., Peters, M., Christie, M., Mendelsohn, C. (2006). Nicotine and nicotine replacement therapy - the facts. Australian Pharmacist, 25(2), 969-973.
  • Christie, M. (2006). Opioid and cannabinoid receptors: Friends with benefits or just close friends? British Journal of Pharmacology, 148(4), 385-386. [More Information]
  • Riddell, S., Nielssen, O., Butler, T., Christie, M., Starmer, G. (2006). The Relationship Between Amphetamine Use, Crime and Psychiatric Disorder Among Prisoners in New South Wales. Psychiatry Psychology and Law, 13(2), 160-165.
  • Liu, X., Banister, S., Christie, M., Banati, R., Meikle, S., Coster, M., Kassiou, M. (2006). Trishomocubanes: Novel Sigma ligands modulate cocaine-induced behavioural effects. European Journal of Pharmacology, 555(1), 37-42. [More Information]
  • Ekberg, J., Jayamanne, A., Vaughan, C., Aslan, S., Thomas, L., Mould, J., Drinkwater, R., Baker, M., Abrahamsen, B., Wood, J., Christie, M., et al (2006). {micro}O-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 103(45), 17030-17035. [More Information]
  • Hall, W., Christie, M., Currow, D. (2005). Cannabinoids and cancer: causation, remediation, and palliation. Lancet Oncology, 6(1), 35-42. [More Information]
  • Marinelli, S., Connor, M., Schnell, S., Christie, M., Wessendorf, M., Vaughan, C. (2005). delta-OPIOID RECEPTOR-MEDIATED ACTIONS ON ROSTRAL VENTROMEDIAL MEDULLA NEURONS. Neuroscience, 132(2), 239-244. [More Information]
  • Chieng, B., Hallberg, C., Nyberg, F., Christie, M. (2005). Enhanced c-Fos in periaqueductal grey GABAergic neurons during opioid withdrawal. NeuroReport, 16(12), 1279-1283. [More Information]
  • Bagley, E., Gerke, M., Vaughan, C., Hack, S., Christie, M. (2005). GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron, 45(3), 433-445. [More Information]
  • Hack, S., Bagley, E., Chieng, B., Christie, M. (2005). Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. The Journal of Neuroscience, 25(12), 3192-3198. [More Information]
  • Liu, X., Mattner, F., Katsifis, A., Christie, M., Kassiou, M. (2005). Influence of Trishomocubanes on Sigma Receptor Binding of N-(1-Benzylpiperidin- 4-yl)-4-[123I]iodobenzamide In Vivo in the Rat Brain. Medicinal Chemistry, 1(1), 31-38. [More Information]
  • Bagley, E., Chieng, B., Christie, M., Connor, M. (2005). Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. British Journal of Pharmacology, 146(1), 68-76. [More Information]
  • Hauser, K., Aldrich, J., Anderson, K., Bakalkin, G., Christie, M., Hall, E., Knapp, P., Scheff, S., Singh, I., Vissel, B., et al (2005). Pathobiology of dynorphins in trauma and disease. Frontiers in Bioscience, 10(1), 216-235.
  • Johnson, E., Christie, M., Connor, M. (2005). The Role of Opioid Receptor Phosphorylation and Trafficking in Adaptations to Persistent Opioid Treatment. NeuroSignals, 14(6), 290-302. [More Information]
  • Connor, M., Bagley, E., Mitchell, V., Ingram, S., Christie, M., Humphrey, P., Vaughan, C. (2004). Cellular Actions Of Somatostatin On Rat Periaqueductal Grey Neurons In Vitro. British Journal of Pharmacology, 142(8), 1273-1280.
  • Dean, A., Bell, J., Christie, M., Mattick, R. (2004). Depressive Symptoms During Buprenorphine Vs. Methadone Maintenance: Findings From A Randomised, Controlled Trial In Opioid Dependence. European Psychiatry, 19(8), 510-513. [More Information]
  • Jennings, E., Ryan, R., Christie, M. (2004). Effects Of Sumatriptan On Rat Medullary Dorsal Horn Neurons. Pain, 111(1-2), 30-37.
  • Connor, M., Osborne, P., Christie, M. (2004). Mu-Opioid Receptor Desentization: Is Morphine Different? British Journal of Pharmacology, 143(6), 685-696.
  • Marinelli, S., Schnell, S., Hack, S., Christie, M., Wessendorf, M., Vaughan, C. (2004). Serotonergic And Nonserotonergic Dorsal Raphe Neurons Are Pharmacologically And Electrophysiologically Heterogeneous. Journal of Neurophysiology, 92(6), 3532-3537.
  • Hack, S., Christie, M. (2003). Adaptations in adenosine signaling in drug dependence: therapeutic implications. Critical Reviews in Neurobiology, 15(3-4), 235-274.
  • Vaughan, C., Bagley, E., Drew, G., Schuller, A., Pintar, J., Hack, S., Christie, M. (2003). Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. British Journal of Pharmacology, 139(2), 362-367.
  • Mitchell, V., Christie, M., Vaughan, C. (2003). Developmental changes in the alpha-adrenergic responses of rat periaqueductal grey neurons. NeuroReport, 14(12), 1637-1639.
  • Hack, S., Vaughan, C., Christie, M. (2003). Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro. Neuropharmacology, 45(5), 575-584.
  • Lonergan, T., Goodchild, A., Christie, M., Pilowsky, P. (2003). Mu opioid receptors in rat ventral medulla: effects of endomorphin-1 on phrenic nerve activity. Respiratory Physiology and Neurobiology, 138(2-3), 165-178.
  • Borgland, S., Connor, M., Osborne, P., Furness, J., Christie, M. (2003). Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization and endocytosis of Mu-opioid receptors. Journal of Biological Chemistry, 278(21), 18776-18784. [More Information]
  • Lonergan, T., Goodchild, A., Christie, M., Pilowsky, P. (2003). Presynaptic delta opioid receptors differentially modulate rhythm and pattern generation in the ventral respiratory group of the rat. Neuroscience, 121(4), 959-973.
  • Jennings, E., Vaughan, C., Roberts, L., Christie, M. (2003). The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. The Journal of Physiology, 548(1), 121-129.
  • King, W., Borland, R., Christie, M. (2003). Way-out developments at BATCO. Tobacco Control, 12(1), 107-108.
  • Dean, A., Bell, J., Mascord, D., Parker, G., Christie, M. (2002). A randomised, controlled trial of fluoxetine in methadone maintenance patients with depressive symptoms. Journal of Affective Disorders, 72(1), 85-90.
  • Roberts, L., Christie, M., Connor, M. (2002). Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. British Journal of Pharmacology, 137(4), 421-428.
  • Marinelli, S., Vaughan, C., Christie, M., Connor, M. (2002). Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. The Journal of Physiology, 543(2), 531-540.
  • Osborne, P., Vidovic, M., Chieng, B., Hill, C., Christie, M. (2002). Expression of mRNA and functional alpha1-adrenoceptors that supress the GIRK conductance in adult rat locus coeruleus neurons. British Journal of Pharmacology, 13(1), 226-232.
  • Dedov, V., Tran, V., Duke, C., Connor, M., Christie, M., Mandadi, S., Roufogalis, B. (2002). Gingerols: a novel class of vanilloid receptor (VR1) agonists. British Journal of Pharmacology, 137(6), 793-798.
  • Borgland, S., Connor, M., Ryan, R., Ball, H., Christie, M. (2002). Prostaglandin E2 inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. The Journal of Physiology, 539(2), 433-444.
  • Marinelli, S., Vaughan, C., Schnell, S., Wessendorf, M., Christie, M. (2002). Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes. The Journal of Neuroscience, 22(24), 10847-10855.
  • Vaughan, C., Connor, M., Jennings, E., Marinelli, S., Christie, M., Allen, R. (2001). Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro. The Journal of Physiology, 534, 849-859.
  • Jennings, E., Vaughan, C., Christie, M. (2001). Cannabinoid actions on rat superficial medullary dorsal horn neurons in vitro. The Journal of Physiology, 534, 805-812.
  • Christie, M., Williams, J., Manzoni, O. (2001). Cellular and synaptic adaptations mediating opioid dependence. Physiological Reviews, 81, 299-343.
  • Wang, X., Connor, M., Wilson, D., Wilson, H., Nicholson,, G., Smith, R., Shaw, D., Mackay, J., Alewood, P., Christie, M., et al (2001). Discovery and structure of a potent and highly specific blocker of insect calcium channels. Journal of Biological Chemistry, 276, 40306-40312.
  • Borgland, S., Connor, M., Christie, M. (2001). Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganlion neurons in mouse. The Journal of Physiology, 536, 35-47.
  • Liu, X., Christie, M., Kassiou, M., Nuwayhid, S., Werling, L. (2001). Trishomocubanes: Novel sigma-ligands modulate amphetamine-stimulated [3H]dopamine release. European Journal of Pharmacology, 422, 39-45.
  • Liu, X., Kassiou, M., Christie, M., Hambley, T. (2001). Trishomocubanes: requirements for sigma receptor binding and subtype selectivity. Australian Journal of Chemistry: an international journal for chemical science, 54, 31-36.

Conferences

  • Christie, M., Bagley, E., Hacker, J., Chieng, B. (2006). GABA transporters in drug dependence: Neuronal or glial. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.

Reference Works

  • Christie, M., Osborne, P. (2007). Opioid Electrophysiology in PAG. In Robert F. Schmidt, William D. Willis (Eds.), Encyclopedia of Pain. (pp. 1532-1534). Germany: Springer.

2015

  • Connor, M., Bagley, E., Chieng, B., Christie, M. (2015). beta-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons. British Journal of Pharmacology, 172(2), 492-500. [More Information]
  • Cox, B., Christie, M., Devi, L., Toll, L., Traynor, J. (2015). Challenges for Opioid Receptor Nomenclature: IUPHAR Review 9. British Journal of Pharmacology, 172(2), 317-323. [More Information]
  • Murali, S., Napier, I., Mohammadi, S., Alewood, P., Lewis, R., Christie, M. (2015). High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury. Journal of Neurophysiology, 113(5), 1511-1519. [More Information]
  • Christie, M. (2015). Opioids and their signalling mechanisms at opioid receptors. In Patricia Armati, Roberta Chow (Eds.), Pain: The person, the science, the clinical interface, (pp. 205-220). Melbourne: IP Communications.
  • Christie, M., Connor, M., Traynor, J. (2015). Themed section. British Journal of Pharmacology, 172(2), 247-250. [More Information]
  • Sadeghi, M., Tzschentke, T., Christie, M. (2015). μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons. British Journal of Pharmacology, 172(2), 460-468. [More Information]

2014

  • Mohammadi, S., Christie, M. (2014). Alpha9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia. Molecular Pain, 10(1), 1-9. [More Information]
  • Vandenberg, R., Ryan, R., Carland, J., Imlach, W., Christie, M. (2014). Glycine transport inhibitors for the treatment of pain. Trends In Pharmacological Sciences, 35(8), 423-430. [More Information]
  • Jin, A., Vetter, I., Dutertre, S., Abraham, N., Emidio, N., Inserra, M., Murali, S., Christie, M., Alewood, P., Lewis, R. (2014). MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors. Biochemistry, 53(1), 1-3. [More Information]
  • Shan, Q., Ge, M., Christie, M., Balleine, B. (2014). The acquisition of goal-directed actions generates opposing plasticity in direct and indirect pathways in dorsomedial striatum. The Journal of Neuroscience, 34(28), 9196-9201. [More Information]
  • Imlach, W., Christie, M. (2014). The light touch of delta opioid receptors. Neuron, 81(6), 1220-1222. [More Information]

2013

  • Knapman, A., Santiago, M., Du, Y., Bennallack, P., Christie, M., Connor, M. (2013). A Continuous, Fluorescence-based Assay of u-Opioid Receptor Activation in AtT-20 Cells. Journal of Biomolecular Screening, 18(3), 269-276. [More Information]
  • Saberi, S., Du, Y., Christie, M., Goldsbury, C. (2013). Human Chorionic Gonadotropin Increases b-Cleavage of Amyloid Precursor Protein in SH-SY5Y Cells. Cellular and Molecular Neurobiology, 33(6), 747-751. [More Information]
  • Bertran-Gonzalez, J., Laurent, V., Chieng, B., Christie, M., Balleine, B. (2013). Learning-related translocation of δ-Opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions. The Journal of Neuroscience, 33(41), 16060-16071. [More Information]
  • Sadeghi, M., Murali, S., Lewis, R., Alewood, P., Mohammadi, S., Christie, M. (2013). Novel [omega]-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration. Molecular Pain, 9(1), 1-9. [More Information]
  • Williams, J., Ingram, S., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C., Christie, M. (2013). Regulation of & mu; -Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance. Pharmacological Reviews, 65(1), 223-254. [More Information]
  • Jayamanne, A., Jeong, H., Schroeder, C., Lewis, R., Christie, M., Vaughan, C. (2013). Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology, 170(2), 245-254. [More Information]
  • Brust, A., Wang, C., Daly, N., Kennerly, J., Sadeghi, M., Christie, M., Lewis, R., Mobli, M., Alewood, P. (2013). Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter. Angewandte Chemie (International Edition), 52(46), 12020-12023. [More Information]

2012

  • Vetter, I., Mozar, C., Durek, T., Wingerd, J., Alewood, P., Christie, M., Lewis, R. (2012). Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology, 83(11), 1562-1571. [More Information]
  • Lewis, R., Dutertre, S., Vetter, I., Christie, M. (2012). Conus venom peptide pharmacology. Pharmacological Reviews, 64(2), 259-298. [More Information]
  • Napier, I., Mohammadi, S., Christie, M. (2012). Glutamate transporter dysfunction associated with nerve injury-induced pain in mice. Journal of Neurophysiology, 107(2), 649-657. [More Information]
  • Napier, I., Klimis, H., Rycroft, B., Jin, A., Alewood, P., Motin, L., Adams, D., Christie, M. (2012). Intrathecal a-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology, 62(7), 2202-2207. [More Information]
  • Dang, V., Christie, M. (2012). Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons. British Journal of Pharmacology, 165(6), 1704-1716. [More Information]
  • Graeber, M., Christie, M. (2012). Multiple mechanisms of microglia: a gatekeeper's contribution to pain states. Experimental Neurology, 234(2), 255-261. [More Information]
  • Enoksson, T., Bertran-Gonzalez, J., Christie, M. (2012). Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively. Neuropharmacology, 62(8), 2463-2471. [More Information]
  • Murali, S., Napier, I., Rycroft, B., Christie, M. (2012). Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels. The Journal of Physiology, 590(7), 1655-1667. [More Information]
  • Dang, V., Chieng, B., Christie, M. (2012). Prolonged stimulation of u-opioid receptors produces B-arrestin-2-mediated heterologous desensitization of a2-adrenoceptor function in locus ceruleus neurons. Molecular Pharmacology, 82(3), 473-480. [More Information]

2011

  • Klimis, H., Adams, D., Callaghan, B., Nevin, S., Alewood, P., Vaughan, C., Mozar, C., Christie, M. (2011). A Novel Mechanism of Inhibition of High-Voltage Activated Calcium Channels by alpha-Conotoxins Contributes to Relief of Nerve Injury-Induced Neuropathic Pain. Pain, 152(2), 259-266. [More Information]
  • Morgan, M., Christie, M. (2011). Analysis of Opioid Efficacy, Tolerance, Addiction, and Dependence from Cell Culture to Human. British Journal of Pharmacology, 164(4), 1322-1334. [More Information]
  • Dang, V., Chieng, B., Azriel, Y., Christie, M. (2011). Cellular Morphine Tolerance Produced by {beta}Arrestin-2-Dependent Impairment of {mu}-Opioid Receptor Resensitization. The Journal of Neuroscience, 31(19), 7122-7130. [More Information]
  • Chieng, B., Azriel, Y., Mohammadi, S., Christie, M. (2011). Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area. The Journal of Physiology, 589(15), 3775-3787. [More Information]
  • Bagley, E., Hacker, J., Chefer, V., Mallet, C., McNally, G., Chieng, B., Perroud, J., Shippenberg, T., Christie, M. (2011). Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nature Neuroscience, 14(12), 1548-1554. [More Information]
  • Kawahara, H., Drew, G., Christie, M., Vaughan, C. (2011). Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey. British Journal of Pharmacology, 163(6), 1214-1222. [More Information]
  • Pedersen, N., Vaughan, C., Christie, M. (2011). Opioid receptor modulation of GABAergic and serotonergic spinally-projecting neurons of the rostral ventromedial medulla in mice. Journal of Neurophysiology, 106(2), 731-740. [More Information]
  • Christie, M., Vaughan, C. (2011). Receptors: Cannabis medicine without a high. Nature Chemical Biology. [More Information]
  • de Araujo, A., Callaghan, B., Nevin, S., Daly, N., Craik, D., Moretta, M., Hopping, G., Christie, M., Alewood, P., Adams, D. (2011). Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-assisted Folding. Angewandte Chemie (International Edition), 50(29), 6527-6529. [More Information]

2010

  • Berecki, G., Motin, L., Haythornthwaite, A., Vink, S., Bansal, P., Drinkwater, R., Wang, C., Moretta, M., Lewis, R., Alewood, P., Christie, M., et al (2010). Analgesic omega-Conotoxins CVIE and CVIF Selectively and Voltage-Dependently Block Recombinant and Native N-Type Calcium Channels. Molecular Pharmacology, 77(2), 139-148. [More Information]
  • Morales, R., Daly, N., Vetter, I., Mobli, M., Napier, I., Craik, D., Lewis, R., Christie, M., King, G., Alewood, P., et al (2010). Chemical Synthesis and Structure of the Prokineticin Bv8. ChemBioChem: a European journal of chemical biology, 11(13), 1882-1888. [More Information]
  • Ittner, L., Ke, Y., Delerue, F., Bi, M., Gladbach, A., Van Eersel, J., Wolfing, H., Chieng, B., Christie, M., Napier, I., Goetz, J., et al (2010). Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell, 142(3), 387-397. [More Information]
  • Chieng, B., Christie, M. (2010). Somatostatin and nociceptin inhibit neurons in the central nucleus of amygdala that project to the periaqueductal grey. Neuropharmacology, 59(6), 425-430. [More Information]

2009

  • Morgan, M., Ashley, M., Ingram, S., Christie, M. (2009). Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats. Neural Plasticity, 2009 (516328), 1-7. [More Information]
  • Chieng, B., Christie, M. (2009). Chronic morphine treatment induces functional delta-opioid receptors in amygdala neurons that project to periaqueductal grey. Neuropharmacology, 57(4), 430-437. [More Information]
  • Christie, M., Mallet, C. (2009). Endocannabinoids can open the pain gate. Science Signaling, 2(88), 57. [More Information]
  • Dang, V., Napier, I., Christie, M. (2009). Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. The Journal of Neuroscience, 29(10), 3322-3327. [More Information]

2008

  • Christie, M. (2008). Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction. British Journal of Pharmacology, 154(2), 384-396. [More Information]
  • Chieng, B., Lee, D., Du, Y., Osborne, P., Christie, M., Massottec, D. (2008). Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells. NeuroReport, 19(18), 1793-1796. [More Information]

2007

  • Nevin, S., Clark, R., Klimis, H., Christie, M., Craik, D., Adams, D. (2007). Are alpha 9 alpha 10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Molecular Pharmacology, 72(6), 1406-1410.
  • Nevin, S., Clark, R., Klimis, H., Christie, M., Craik, D., Adams, D. (2007). Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Molecular Pharmacology, 72(6), 1406-1410. [More Information]
  • Rycroft, B., Vikman, K., Christie, M. (2007). Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn. The Journal of Physiology, 580(3), 883-894. [More Information]
  • Christie, M., Osborne, P. (2007). Opioid Electrophysiology in PAG. In Robert F. Schmidt, William D. Willis (Eds.), Encyclopedia of Pain. (pp. 1532-1534). Germany: Springer.
  • Vikman, K., Rycroft, B., Christie, M. (2007). Switch to Ca2+ permeable AMPA and reduced NR2B NMDA receptor mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat. The Journal of Physiology, 586(2), 515-527. [More Information]
  • Liu, X., Banister, S., Christie, M., Banati, R., Meikle, S., Coster, M., Kassiou, M. (2007). Trishomocubanes: Novel sigma ligands modulate cocaine-induced behavioural effects. European Journal of Pharmacology, 555(1), 37-42.

2006

  • Jennings, E., Christie, M., Sessle, B. (2006). ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis. NeuroReport, 17(14), 1507-1510. [More Information]
  • Chieng, B., Christie, M., Osborne, P. (2006). Characterization of neurons in the rat central nucleus of the amygdala: Cellular physiology, morphology, and opioid sensitivity. The Journal of Comparative Neurology, 497(6), 910-927. [More Information]
  • Hacker, J., Pedersen, N., Chieng, B., Keay, K., Christie, M. (2006). Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal. Neuroscience, 137(4), 1389-1396. [More Information]
  • Christie, M., Bagley, E., Hacker, J., Chieng, B. (2006). GABA transporters in drug dependence: Neuronal or glial. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Zwar, N., Bell, J., Peters, M., Christie, M., Mendelsohn, C. (2006). Nicotine and nicotine replacement therapy - the facts. Australian Pharmacist, 25(2), 969-973.
  • Christie, M. (2006). Opioid and cannabinoid receptors: Friends with benefits or just close friends? British Journal of Pharmacology, 148(4), 385-386. [More Information]
  • Riddell, S., Nielssen, O., Butler, T., Christie, M., Starmer, G. (2006). The Relationship Between Amphetamine Use, Crime and Psychiatric Disorder Among Prisoners in New South Wales. Psychiatry Psychology and Law, 13(2), 160-165.
  • Liu, X., Banister, S., Christie, M., Banati, R., Meikle, S., Coster, M., Kassiou, M. (2006). Trishomocubanes: Novel Sigma ligands modulate cocaine-induced behavioural effects. European Journal of Pharmacology, 555(1), 37-42. [More Information]
  • Ekberg, J., Jayamanne, A., Vaughan, C., Aslan, S., Thomas, L., Mould, J., Drinkwater, R., Baker, M., Abrahamsen, B., Wood, J., Christie, M., et al (2006). {micro}O-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 103(45), 17030-17035. [More Information]

2005

  • Hall, W., Christie, M., Currow, D. (2005). Cannabinoids and cancer: causation, remediation, and palliation. Lancet Oncology, 6(1), 35-42. [More Information]
  • Marinelli, S., Connor, M., Schnell, S., Christie, M., Wessendorf, M., Vaughan, C. (2005). delta-OPIOID RECEPTOR-MEDIATED ACTIONS ON ROSTRAL VENTROMEDIAL MEDULLA NEURONS. Neuroscience, 132(2), 239-244. [More Information]
  • Chieng, B., Hallberg, C., Nyberg, F., Christie, M. (2005). Enhanced c-Fos in periaqueductal grey GABAergic neurons during opioid withdrawal. NeuroReport, 16(12), 1279-1283. [More Information]
  • Bagley, E., Gerke, M., Vaughan, C., Hack, S., Christie, M. (2005). GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron, 45(3), 433-445. [More Information]
  • Hack, S., Bagley, E., Chieng, B., Christie, M. (2005). Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. The Journal of Neuroscience, 25(12), 3192-3198. [More Information]
  • Liu, X., Mattner, F., Katsifis, A., Christie, M., Kassiou, M. (2005). Influence of Trishomocubanes on Sigma Receptor Binding of N-(1-Benzylpiperidin- 4-yl)-4-[123I]iodobenzamide In Vivo in the Rat Brain. Medicinal Chemistry, 1(1), 31-38. [More Information]
  • Vaughan, C., Christie, M. (2005). Mechanisms of cannabinoid analgesia. Cannabis and Cannabinoids: Pharmacology, Toxicology and Therapeutic Potential, (pp. 89-100). UK: Harworth Press.
  • Bagley, E., Chieng, B., Christie, M., Connor, M. (2005). Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. British Journal of Pharmacology, 146(1), 68-76. [More Information]
  • Hauser, K., Aldrich, J., Anderson, K., Bakalkin, G., Christie, M., Hall, E., Knapp, P., Scheff, S., Singh, I., Vissel, B., et al (2005). Pathobiology of dynorphins in trauma and disease. Frontiers in Bioscience, 10(1), 216-235.
  • Vaughan, C., Christie, M. (2005). Retrograde signalling by endocannabinoids. In Pertwee R (Eds.), Handbook of Experimental Pharmacology, (pp. 367-384). Heidelberg: Springer.
  • Johnson, E., Christie, M., Connor, M. (2005). The Role of Opioid Receptor Phosphorylation and Trafficking in Adaptations to Persistent Opioid Treatment. NeuroSignals, 14(6), 290-302. [More Information]

2004

  • Connor, M., Bagley, E., Mitchell, V., Ingram, S., Christie, M., Humphrey, P., Vaughan, C. (2004). Cellular Actions Of Somatostatin On Rat Periaqueductal Grey Neurons In Vitro. British Journal of Pharmacology, 142(8), 1273-1280.
  • Dean, A., Bell, J., Christie, M., Mattick, R. (2004). Depressive Symptoms During Buprenorphine Vs. Methadone Maintenance: Findings From A Randomised, Controlled Trial In Opioid Dependence. European Psychiatry, 19(8), 510-513. [More Information]
  • Jennings, E., Ryan, R., Christie, M. (2004). Effects Of Sumatriptan On Rat Medullary Dorsal Horn Neurons. Pain, 111(1-2), 30-37.
  • Christie, M., Vaughan, C. (2004). Mechanismen Der Cannabinoidanalgesie. In Franjo Grotenhermen (Eds.), Cannabis und Cannabinoide, (pp. 115-125). Bern: Nicholson Museum, University of Sydney.
  • Connor, M., Osborne, P., Christie, M. (2004). Mu-Opioid Receptor Desentization: Is Morphine Different? British Journal of Pharmacology, 143(6), 685-696.
  • Marinelli, S., Schnell, S., Hack, S., Christie, M., Wessendorf, M., Vaughan, C. (2004). Serotonergic And Nonserotonergic Dorsal Raphe Neurons Are Pharmacologically And Electrophysiologically Heterogeneous. Journal of Neurophysiology, 92(6), 3532-3537.

2003

  • Hack, S., Christie, M. (2003). Adaptations in adenosine signaling in drug dependence: therapeutic implications. Critical Reviews in Neurobiology, 15(3-4), 235-274.
  • Vaughan, C., Bagley, E., Drew, G., Schuller, A., Pintar, J., Hack, S., Christie, M. (2003). Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. British Journal of Pharmacology, 139(2), 362-367.
  • Mitchell, V., Christie, M., Vaughan, C. (2003). Developmental changes in the alpha-adrenergic responses of rat periaqueductal grey neurons. NeuroReport, 14(12), 1637-1639.
  • Hack, S., Vaughan, C., Christie, M. (2003). Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro. Neuropharmacology, 45(5), 575-584.
  • Lonergan, T., Goodchild, A., Christie, M., Pilowsky, P. (2003). Mu opioid receptors in rat ventral medulla: effects of endomorphin-1 on phrenic nerve activity. Respiratory Physiology and Neurobiology, 138(2-3), 165-178.
  • Borgland, S., Connor, M., Osborne, P., Furness, J., Christie, M. (2003). Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization and endocytosis of Mu-opioid receptors. Journal of Biological Chemistry, 278(21), 18776-18784. [More Information]
  • Lonergan, T., Goodchild, A., Christie, M., Pilowsky, P. (2003). Presynaptic delta opioid receptors differentially modulate rhythm and pattern generation in the ventral respiratory group of the rat. Neuroscience, 121(4), 959-973.
  • Jennings, E., Vaughan, C., Roberts, L., Christie, M. (2003). The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. The Journal of Physiology, 548(1), 121-129.
  • King, W., Borland, R., Christie, M. (2003). Way-out developments at BATCO. Tobacco Control, 12(1), 107-108.

2002

  • Dean, A., Bell, J., Mascord, D., Parker, G., Christie, M. (2002). A randomised, controlled trial of fluoxetine in methadone maintenance patients with depressive symptoms. Journal of Affective Disorders, 72(1), 85-90.
  • Roberts, L., Christie, M., Connor, M. (2002). Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. British Journal of Pharmacology, 137(4), 421-428.
  • Marinelli, S., Vaughan, C., Christie, M., Connor, M. (2002). Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. The Journal of Physiology, 543(2), 531-540.
  • Osborne, P., Vidovic, M., Chieng, B., Hill, C., Christie, M. (2002). Expression of mRNA and functional alpha1-adrenoceptors that supress the GIRK conductance in adult rat locus coeruleus neurons. British Journal of Pharmacology, 13(1), 226-232.
  • Dedov, V., Tran, V., Duke, C., Connor, M., Christie, M., Mandadi, S., Roufogalis, B. (2002). Gingerols: a novel class of vanilloid receptor (VR1) agonists. British Journal of Pharmacology, 137(6), 793-798.
  • Vaughan, C., Christie, M. (2002). Mechanisms of Cannabinoid Analgesia. In Grotenhermen, F & Russo, E (Eds.), Cannibis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential, (pp. 89-99). Binghampton, NY, USA: Staempfli Publishers Ltd.
  • Borgland, S., Connor, M., Ryan, R., Ball, H., Christie, M. (2002). Prostaglandin E2 inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. The Journal of Physiology, 539(2), 433-444.
  • Marinelli, S., Vaughan, C., Schnell, S., Wessendorf, M., Christie, M. (2002). Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes. The Journal of Neuroscience, 22(24), 10847-10855.

2001

  • Vaughan, C., Connor, M., Jennings, E., Marinelli, S., Christie, M., Allen, R. (2001). Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro. The Journal of Physiology, 534, 849-859.
  • Jennings, E., Vaughan, C., Christie, M. (2001). Cannabinoid actions on rat superficial medullary dorsal horn neurons in vitro. The Journal of Physiology, 534, 805-812.
  • Christie, M., Williams, J., Manzoni, O. (2001). Cellular and synaptic adaptations mediating opioid dependence. Physiological Reviews, 81, 299-343.
  • Wang, X., Connor, M., Wilson, D., Wilson, H., Nicholson,, G., Smith, R., Shaw, D., Mackay, J., Alewood, P., Christie, M., et al (2001). Discovery and structure of a potent and highly specific blocker of insect calcium channels. Journal of Biological Chemistry, 276, 40306-40312.
  • Vaughan, C., Christie, M. (2001). Mechanisms of cannabinoid analgesia. In Franjo Grotenhermen (Hrsg) (Eds.), Cannabis and Cannabinoide, (pp. 109-119). Germany: Academic Press.
  • Borgland, S., Connor, M., Christie, M. (2001). Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganlion neurons in mouse. The Journal of Physiology, 536, 35-47.
  • Liu, X., Christie, M., Kassiou, M., Nuwayhid, S., Werling, L. (2001). Trishomocubanes: Novel sigma-ligands modulate amphetamine-stimulated [3H]dopamine release. European Journal of Pharmacology, 422, 39-45.
  • Liu, X., Kassiou, M., Christie, M., Hambley, T. (2001). Trishomocubanes: requirements for sigma receptor binding and subtype selectivity. Australian Journal of Chemistry: an international journal for chemical science, 54, 31-36.

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