Professor Manuel Graeber

MD PhD FRCPath, Neuropathologist
Barnet-Cropper Chair of Brain Tumor Research
Brain & Mind Research Institute
Director, Brain Tumor Research University of Sydney
Editor-in-Chief (co-founding) (1997- ) Neurogenetics
h-index 60, see related website for publications

Telephone +61 2 9114 4008
Fax +61 2 9351 0731

Website Related website

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Biographical details

Honours, Special Recognitions, and Awards

1988 Educational Commission for Foreign Medical Graduates (ECFMG, USA)

1989 Otto-Hahn-Medal of the Max-Planck-Society, Germany

1993 Invitation to apply for the position of Neuropathologist-in-Chief at the Montreal

Neurological Hospital and Institute, McGill University, Montreal, Canada

1993 Gerhard Hess-Award of the German Research Foundation

1995 Center of Excellence Visiting Scientist Award, National Institute of

Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan

2001 Offer of appointment (as non-applicant): Directorship of the Institute of

Neuropathology and Chair of Neuropathology at the University of Hamburg

2004 Elected to the Athenaeum, London, UK

Other Editorial Boards

Journal of Neuroscience Research (1993 - )

Developmental Neuroscience (1993 - 2009)

Brain Pathology (1995 - )

Journal of Neurocytology (1998 - 2006)

Journal of Neural Transmission (1998 - 2003)

Acta Neuropathologica (2000 - )

Journal of Neuroinflammation (2003 - )

PLoS Medicine (2004 - )

Frontiers in Neurotrauma (2010 - )

SRX Neuroscience (2010, discontinued)

World Journal of Neurology (2011 - )

World Journal of Medical Genetics (2011 - )

Neural Plasticity (2011 - )

Neuroglia (2012 - 2013, discontinued)

World Journal of Clinical Cases (2012 - )

Previous positions

2000-2007 Professor of Neuropathology and Chair (founding), University

Department of Neuropathology, Imperial College London; responsible

diagnostic neuropathologist of the UK Multiple Sclerosis and

Parkinson's Disease national brain banks

2007 Co-chair of the Launch of the European Fellowship in Neuropathology

2009 Head of Neuropathology, King Fahd Med. City, Ministry of Health,

Riyadh, KSA

Licensure and Certifications: 1996 Board Certification in

Neuropathology, Germany; 1999 Board Certification in

Neuropathology, United Kingdom; 2009 Board Certification in

Neuropathology, KSA

Education

U Saarbrücken, U Heidelberg, and Technical University of Munich

Medical Studies

Technical University of Munich

Max-Planck-Institute of Psychiatry - Technical University of Munich

MD exam

Dr med (distinction/summa cum laude)

1987

1988

Medicine

Medicine

Ludwig-Maximilians University, Munich, Germany

Dr med habil (DSc/PhD)

1995

Neuropathology

Harvard Medical School, Brigham and Women's Hospital

Research Fellow

1989-1990

Neurology

Harvard Medical School, Children’s Hospital, Boston, MA, USA

Institute of Neuropathology, University of Munich

Max-Planck-Institute of Neurobiology, Martinsried n. Munich

Royal College of Pathologists, London, UK

Research Fellow

Equiv. Asst. Prof.

Senior Staff Member

Fellow (FRCPath)

1990-1992

1992-1996

1996-1999

2005

Genetics

Neuropathology

Molecular Neuropathology

Neuropathology

Research interests

Microglia in glioma 1

Brain Banking 1, 2

Parkinson's disease 1

Alzheimer's disease 1, 2

Teaching and supervision

Clinical Neuropathology

Experimental Neuropathology

Selected grants

2014

  • Development of multi-ligand imaging in a unique live null background model; Graeber M, Banati R; Australian Institute of Nuclear Science and Engineering (AINSE)/Research Projects.
  • Support for glioma model; Graeber M; Cure for Life Foundation/Research Grants.

2013

  • Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.
  • A high-throughput, bright-field and fluorescence digital slide scanning platform and service that is both research and teaching-focused and available University-wide.; King N, Graeber M, Naylor M, Slapeta J, Quinnell R, Charles (nee Slaviero) K, Owens T, Bourne R, Braet F, Hambly B, Overall R, Stone J, Twigg S, Hardikar A, Halliday G, Richardson D, Byrne M, Keay K, Marsh D, Howell V, Pollock C, Chen X; DVC Research/Equipment Grant.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Graeber, M., Flugel, A., Moran, L., Scheithauer, B. (2010). Immune Biology of Microglia in Gliomas. In D. K. Stavrou & C. Hagel (Eds.), Immune Biology of Brain Tumours, (pp. 69-80). Munchen: Dustri-Verlag Dr. Karl Feistle.

Journals

  • Duffy, S., Lagopoulos, J., Hickie, I., Diamond, K., Graeber, M., Lewis, S., Naismith, S. (2014). Glutathione relates to neuropsychological functioning in mild cognitive impairment. Alzheimer's and Dementia, 10(1), 67-75. [More Information]
  • Sajjan, S., Holsinger, D., Fok, S., Ebrahimkhani, S., Rollo, J., Banati, R., Graeber, M. (2014). Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping. Neuroscience, 274, 331-340. [More Information]
  • Muller, U., Winter, P., Graeber, M. (2013). A presenilin 1 mutation in the first case of Alzheimer's disease. Lancet Neurology, 12(2), 129-130. [More Information]
  • Svahn, A., Graeber, M., Ellett, F., Lieschke, G., Rinkwitz, S., Bennett, M., Becker, T. (2013). Development of Ramified Microglia from Early Macrophages in the Zebrafish Optic Tectum. Developmental Neurobiology, 73(1), 60-71. [More Information]
  • Li, W., Holsinger, D., Kruse, C., Flugel, A., Graeber, M. (2013). The Potential for Genetically Altered Microglia to Influence Glioma Treatment. CNS & Neurological Disorders - Drug Targets, 12(6), 750-762. [More Information]
  • Graeber, M., Banati, R., Flugel, A., Streit, W., Tetzlaff, W. (2012). Courage, luck and patience: In celebration of the 80th birthday of Georg W. Kreutzberg. Acta Neuropathologica, 124(4), 593-598. [More Information]
  • Graeber, M., Christie, M. (2012). Multiple mechanisms of microglia: a gatekeeper's contribution to pain states. Experimental Neurology, 234(2), 255-261. [More Information]
  • Li, W., Graeber, M. (2012). The molecular profile of microglia under the influence of glioma. Neuro-Oncology, 14(8), 958-978. [More Information]
  • Alafuzoff, I., Gelpi, E., Al-Sarraj, S., Arzberger, T., Attems, J., Bodi, I., Bogdanovic, N., Budka, H., Bugiani, O., Englund, E., Graeber, M., et al (2012). The need to unify neuropathological assessments of vascular alterations in the ageing brain: multicentre survey by the BrainNet Europe consortium. Experimental Gerontology, 47(11), 825-833. [More Information]
  • Paradise, M., Naismith, S., Norrie, L., Graeber, M., Hickie, I. (2012). The role of glia in late-life depression. International Psychogeriatrics, 24(12), 1878-1890. [More Information]
  • Muller, U., Winter, P., Graeber, M. (2011). Alois Alzheimer's case, Auguste D., did not carry the N141I mutation in PSEN2 characteristic of Alzheimer disease in Volga Germans. JAMA Neurology, 68(9), 1210-1211. [More Information]
  • AlShakweer, W., Alwelaie, Y., Mankung, A., Graeber, M. (2011). Bone marrow-derived microglia in pilocytic astrocytoma. Frontiers in Bioscience (Elite Edition), E3, 371-379. [More Information]
  • Graeber, M. (2011). Ensuring Respect for the Donated Brains of Children http://blogs.plos.org/speakingofmedicine/2011/12/21/ensuring-respect-for-the-donated-brains-of-children. PLoS One, Dec, 21-21.
  • Graeber, M., Li, W., Rodriguez, M. (2011). Role of microglia in CNS inflammation. FEBS Letters, 585, 3798-3805. [More Information]
  • Michael, G., Esmailzadeh, S., Moran, L., Christian, L., Pearce, R., Graeber, M. (2011). Up-regulation of metallothionein gene expression in Parkinsonian astrocytes. Neurogenetics, 12(4), 295-305. [More Information]
  • Graeber, M. (2010). Changing face of microglia. Science, 330(6005), 783-788. [More Information]
  • Graeber, M., Streit, W. (2010). Microglia: biology and pathology. Acta Neuropathologica, 119(1), 89-105. [More Information]
  • Zheng, B., Liao, Z., Locascio, J., Lesniak, K., Roderick, S., Watt, M., Eklund, A., Zhang-James, Y., Kim, P., Hauser, M., Graeber, M., et al (2010). PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease. Science Translational Medicine, 2(52), 1-14. [More Information]
  • Alafuzoff, I., Thal, D., Arzberger, T., Bogdanovic, N., Al-Sarraj, S., Bodi, I., Boluda, S., Bugiani, O., Duyckaerts, C., Gelpi, E., Graeber, M., et al (2009). Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. Acta Neuropathologica, 117(3), 309-320. [More Information]
  • Graeber, M. (2009). Biomarkers for Parkinson's disease. Experimental Neurology, 216(2), 249-53. [More Information]
  • Kalaitzakis, M., Christian, L., Moran, L., Graeber, M., Pearce, R., Gentleman, S. (2009). Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease. Parkinsonism and Related Disorders, 15(3), 196-204. [More Information]
  • Durrenberger, P., Filiou, M., Michael, G., Novoselov, S., Cheetham, M., Clark, P., Pearce, R., Graeber, M. (2009). DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes. Journal of Neuroscience Research, 87(1), 238-245. [More Information]
  • Slodzinski, H., Moran, L., Michael, G., Wang, B., Novoselov, S., Cheetham, M., Pearce, R., Graeber, M. (2009). Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies. Clinical Neuropathology, 28(5), 333-343. [More Information]
  • Kalaitzakis, M., Graeber, M., Gentleman, S., Pearce, R. (2008). Controversies over the staging of alpha-synuclein pathology in Parkinson's disease. Acta Neuropathologica, 116(1), 125-128. [More Information]
  • Moran, L., Hickey, L., Michael, G., Derkacs, M., Christian, L., Kalaitzakis, M., Pearce, R., Graeber, M. (2008). Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. Acta Neuropathologica, 115(4), 471-478. [More Information]
  • Alafuzoff, I., Arzberger, T., Al-Sarraj, S., Bodi, I., Bogdanovic, N., Braak, H., Bugiani, O., Del-Tredici, K., Ferrer, I., Gelpi, E., et al (2008). Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain Pathology, 18(4), 484-496. [More Information]
  • Kalaitzakis, M., Graeber, M., Gentleman, S., Pearce, R. (2008). Striatal beta-amyloid deposition in Parkinson disease with dementia. Journal of Neuropathology and Experimental Neurology, 67(2), 155-161. [More Information]
  • Kalaitzakis, M., Graeber, M., Gentleman, S., Pearce, R. (2008). The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging. Neuropathology and Applied Neurobiology, 34(3), 284-295. [More Information]
  • Moran, L., Graeber, M. (2008). Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation. Neurogenetics, 9(1), 1-13. [More Information]
  • Graeber, M. (2008). Twenty-first century brain banking: at the crossroads. Acta Neuropathologica, 115(5), 493-496. [More Information]
  • Moran, L., Croisier, E., Duke, D., Kalaitzakis, M., Roncaroli, F., Deprez, M., Dexter, D., Pearce, R., Graeber, M. (2007). Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra. Acta Neuropathologica, 113(3), 253-263. [More Information]
  • Harris, J., Fernandez-Vilaseca, M., Elkington, P., Horncastle, D., Graeber, M., Friedland, J. (2007). IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis. The FASEB Journal, 21(2), 356-365. [More Information]
  • Geranmayeh, F., Scheithauer, B., Spitzer, C., Meyer, F., Svensson-Engwall, A., Graeber, M. (2007). Microglia in gemistocytic astrocytomas. Neurosurgery, 60(1), 159-166. [More Information]
  • Harris, J., Nuttall, R., Elkington, P., Green, J., Horncastle, D., Graeber, M., Edwards, D., Friedland, J. (2007). Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo. Journal of Immunology, 178(2), 1199-1207. [More Information]
  • Duke, D., Moran, L., Pearce, R., Graeber, M. (2007). The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability. Neurogenetics, 8(2), 83-94. [More Information]
  • Moran, L., Duke, D., Graeber, M. (2007). The microglial gene regulatory network activated by interferon-gamma. Journal of Neuroimmunology, 183(1-2), 1-6. [More Information]
  • Croisier, E., MRes, D., Deprez, M., Goldring, K., Dexter, D., Pearce, R., Graeber, M., Roncaroli, F. (2006). Comparative study of commercially available anti-alpha-synuclein antibodies. Neuropathology and Applied Neurobiology, 32(3), 351-356. [More Information]
  • Croisier, E., Graeber, M. (2006). Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration. Acta Neuropathologica, 112(5), 517-530. [More Information]
  • Nakajima, K., Graeber, M., Sonoda, M., Tohyama, Y., Kohsaka, S., Kurihara, T. (2006). In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. Journal of Neuroscience Research, 84(2), 348-359. [More Information]
  • Alafuzoff, I., Pikkarainen, M., Al-Sarraj, S., Arzberger, T., Bell, J., Bodi, I., Bogdanovic, N., Budka, H., Bugiani, O., Ferrer, I., et al (2006). Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium. Journal of Neuropathology and Experimental Neurology, 65(8), 740-757. [More Information]
  • Duke, D., Moran, L., Kalaitzakis, M., Deprez, M., Dexter, D., Pearce, R., Graeber, M. (2006). Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease. Neurogenetics, 7(3), 139-148. [More Information]
  • Moran, L., Duke, D., Deprez, M., Dexter, D., Pearce, R., Graeber, M. (2006). Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease. Neurogenetics, 7(1), 1-11. [More Information]
  • Croisier, E., Moran, L., Dexter, D., Pearce, R., Graeber, M. (2005). Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. Journal of Neuroinflammation, 2, 14-1-14-8. [More Information]
  • Duke, D., Moran, L., Turkheimer, F., Banati, R., Graeber, M. (2004). Microglia In Culture: What Genes Do They Express? Developmental Neuroscience, 26(1), 30-37.
  • Banati, R., Egensperger, R., Maassen, A., Hager, G., Kreutzberg, G., Graeber, M. (2004). Mitochondria in activated microglia in vitro. Journal of Neurocytology, 33(5), 353-541. [More Information]
  • Moran, L., Duke, D., Turkheimer, F., Banati, R., Graeber, M. (2004). Towards A Transcriptome Definition Of Microglial Cells. Neurogenetics, 5(2), 95-108. [More Information]

Conferences

  • Holsinger, D., Li, W., Graeber, M. (2012). Microglia as a therapeutic target in glioma. Personalised Medicine Workshop - HMRI, University of Newcastle NSW: Personalised Medicine Workshop HMRI.

2014

  • Duffy, S., Lagopoulos, J., Hickie, I., Diamond, K., Graeber, M., Lewis, S., Naismith, S. (2014). Glutathione relates to neuropsychological functioning in mild cognitive impairment. Alzheimer's and Dementia, 10(1), 67-75. [More Information]
  • Sajjan, S., Holsinger, D., Fok, S., Ebrahimkhani, S., Rollo, J., Banati, R., Graeber, M. (2014). Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping. Neuroscience, 274, 331-340. [More Information]

2013

  • Muller, U., Winter, P., Graeber, M. (2013). A presenilin 1 mutation in the first case of Alzheimer's disease. Lancet Neurology, 12(2), 129-130. [More Information]
  • Svahn, A., Graeber, M., Ellett, F., Lieschke, G., Rinkwitz, S., Bennett, M., Becker, T. (2013). Development of Ramified Microglia from Early Macrophages in the Zebrafish Optic Tectum. Developmental Neurobiology, 73(1), 60-71. [More Information]
  • Li, W., Holsinger, D., Kruse, C., Flugel, A., Graeber, M. (2013). The Potential for Genetically Altered Microglia to Influence Glioma Treatment. CNS & Neurological Disorders - Drug Targets, 12(6), 750-762. [More Information]

2012

  • Graeber, M., Banati, R., Flugel, A., Streit, W., Tetzlaff, W. (2012). Courage, luck and patience: In celebration of the 80th birthday of Georg W. Kreutzberg. Acta Neuropathologica, 124(4), 593-598. [More Information]
  • Holsinger, D., Li, W., Graeber, M. (2012). Microglia as a therapeutic target in glioma. Personalised Medicine Workshop - HMRI, University of Newcastle NSW: Personalised Medicine Workshop HMRI.
  • Graeber, M., Christie, M. (2012). Multiple mechanisms of microglia: a gatekeeper's contribution to pain states. Experimental Neurology, 234(2), 255-261. [More Information]
  • Li, W., Graeber, M. (2012). The molecular profile of microglia under the influence of glioma. Neuro-Oncology, 14(8), 958-978. [More Information]
  • Alafuzoff, I., Gelpi, E., Al-Sarraj, S., Arzberger, T., Attems, J., Bodi, I., Bogdanovic, N., Budka, H., Bugiani, O., Englund, E., Graeber, M., et al (2012). The need to unify neuropathological assessments of vascular alterations in the ageing brain: multicentre survey by the BrainNet Europe consortium. Experimental Gerontology, 47(11), 825-833. [More Information]
  • Paradise, M., Naismith, S., Norrie, L., Graeber, M., Hickie, I. (2012). The role of glia in late-life depression. International Psychogeriatrics, 24(12), 1878-1890. [More Information]

2011

  • Muller, U., Winter, P., Graeber, M. (2011). Alois Alzheimer's case, Auguste D., did not carry the N141I mutation in PSEN2 characteristic of Alzheimer disease in Volga Germans. JAMA Neurology, 68(9), 1210-1211. [More Information]
  • AlShakweer, W., Alwelaie, Y., Mankung, A., Graeber, M. (2011). Bone marrow-derived microglia in pilocytic astrocytoma. Frontiers in Bioscience (Elite Edition), E3, 371-379. [More Information]
  • Graeber, M. (2011). Ensuring Respect for the Donated Brains of Children http://blogs.plos.org/speakingofmedicine/2011/12/21/ensuring-respect-for-the-donated-brains-of-children. PLoS One, Dec, 21-21.
  • Graeber, M., Li, W., Rodriguez, M. (2011). Role of microglia in CNS inflammation. FEBS Letters, 585, 3798-3805. [More Information]
  • Michael, G., Esmailzadeh, S., Moran, L., Christian, L., Pearce, R., Graeber, M. (2011). Up-regulation of metallothionein gene expression in Parkinsonian astrocytes. Neurogenetics, 12(4), 295-305. [More Information]

2010

  • Graeber, M. (2010). Changing face of microglia. Science, 330(6005), 783-788. [More Information]
  • Graeber, M., Flugel, A., Moran, L., Scheithauer, B. (2010). Immune Biology of Microglia in Gliomas. In D. K. Stavrou & C. Hagel (Eds.), Immune Biology of Brain Tumours, (pp. 69-80). Munchen: Dustri-Verlag Dr. Karl Feistle.
  • Graeber, M., Streit, W. (2010). Microglia: biology and pathology. Acta Neuropathologica, 119(1), 89-105. [More Information]
  • Zheng, B., Liao, Z., Locascio, J., Lesniak, K., Roderick, S., Watt, M., Eklund, A., Zhang-James, Y., Kim, P., Hauser, M., Graeber, M., et al (2010). PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease. Science Translational Medicine, 2(52), 1-14. [More Information]

2009

  • Alafuzoff, I., Thal, D., Arzberger, T., Bogdanovic, N., Al-Sarraj, S., Bodi, I., Boluda, S., Bugiani, O., Duyckaerts, C., Gelpi, E., Graeber, M., et al (2009). Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. Acta Neuropathologica, 117(3), 309-320. [More Information]
  • Graeber, M. (2009). Biomarkers for Parkinson's disease. Experimental Neurology, 216(2), 249-53. [More Information]
  • Kalaitzakis, M., Christian, L., Moran, L., Graeber, M., Pearce, R., Gentleman, S. (2009). Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease. Parkinsonism and Related Disorders, 15(3), 196-204. [More Information]
  • Durrenberger, P., Filiou, M., Michael, G., Novoselov, S., Cheetham, M., Clark, P., Pearce, R., Graeber, M. (2009). DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes. Journal of Neuroscience Research, 87(1), 238-245. [More Information]
  • Slodzinski, H., Moran, L., Michael, G., Wang, B., Novoselov, S., Cheetham, M., Pearce, R., Graeber, M. (2009). Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies. Clinical Neuropathology, 28(5), 333-343. [More Information]

2008

  • Kalaitzakis, M., Graeber, M., Gentleman, S., Pearce, R. (2008). Controversies over the staging of alpha-synuclein pathology in Parkinson's disease. Acta Neuropathologica, 116(1), 125-128. [More Information]
  • Moran, L., Hickey, L., Michael, G., Derkacs, M., Christian, L., Kalaitzakis, M., Pearce, R., Graeber, M. (2008). Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. Acta Neuropathologica, 115(4), 471-478. [More Information]
  • Alafuzoff, I., Arzberger, T., Al-Sarraj, S., Bodi, I., Bogdanovic, N., Braak, H., Bugiani, O., Del-Tredici, K., Ferrer, I., Gelpi, E., et al (2008). Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain Pathology, 18(4), 484-496. [More Information]
  • Kalaitzakis, M., Graeber, M., Gentleman, S., Pearce, R. (2008). Striatal beta-amyloid deposition in Parkinson disease with dementia. Journal of Neuropathology and Experimental Neurology, 67(2), 155-161. [More Information]
  • Kalaitzakis, M., Graeber, M., Gentleman, S., Pearce, R. (2008). The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging. Neuropathology and Applied Neurobiology, 34(3), 284-295. [More Information]
  • Moran, L., Graeber, M. (2008). Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation. Neurogenetics, 9(1), 1-13. [More Information]
  • Graeber, M. (2008). Twenty-first century brain banking: at the crossroads. Acta Neuropathologica, 115(5), 493-496. [More Information]

2007

  • Moran, L., Croisier, E., Duke, D., Kalaitzakis, M., Roncaroli, F., Deprez, M., Dexter, D., Pearce, R., Graeber, M. (2007). Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra. Acta Neuropathologica, 113(3), 253-263. [More Information]
  • Harris, J., Fernandez-Vilaseca, M., Elkington, P., Horncastle, D., Graeber, M., Friedland, J. (2007). IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis. The FASEB Journal, 21(2), 356-365. [More Information]
  • Geranmayeh, F., Scheithauer, B., Spitzer, C., Meyer, F., Svensson-Engwall, A., Graeber, M. (2007). Microglia in gemistocytic astrocytomas. Neurosurgery, 60(1), 159-166. [More Information]
  • Harris, J., Nuttall, R., Elkington, P., Green, J., Horncastle, D., Graeber, M., Edwards, D., Friedland, J. (2007). Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo. Journal of Immunology, 178(2), 1199-1207. [More Information]
  • Duke, D., Moran, L., Pearce, R., Graeber, M. (2007). The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability. Neurogenetics, 8(2), 83-94. [More Information]
  • Moran, L., Duke, D., Graeber, M. (2007). The microglial gene regulatory network activated by interferon-gamma. Journal of Neuroimmunology, 183(1-2), 1-6. [More Information]

2006

  • Croisier, E., MRes, D., Deprez, M., Goldring, K., Dexter, D., Pearce, R., Graeber, M., Roncaroli, F. (2006). Comparative study of commercially available anti-alpha-synuclein antibodies. Neuropathology and Applied Neurobiology, 32(3), 351-356. [More Information]
  • Croisier, E., Graeber, M. (2006). Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration. Acta Neuropathologica, 112(5), 517-530. [More Information]
  • Nakajima, K., Graeber, M., Sonoda, M., Tohyama, Y., Kohsaka, S., Kurihara, T. (2006). In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. Journal of Neuroscience Research, 84(2), 348-359. [More Information]
  • Alafuzoff, I., Pikkarainen, M., Al-Sarraj, S., Arzberger, T., Bell, J., Bodi, I., Bogdanovic, N., Budka, H., Bugiani, O., Ferrer, I., et al (2006). Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium. Journal of Neuropathology and Experimental Neurology, 65(8), 740-757. [More Information]
  • Duke, D., Moran, L., Kalaitzakis, M., Deprez, M., Dexter, D., Pearce, R., Graeber, M. (2006). Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease. Neurogenetics, 7(3), 139-148. [More Information]
  • Moran, L., Duke, D., Deprez, M., Dexter, D., Pearce, R., Graeber, M. (2006). Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease. Neurogenetics, 7(1), 1-11. [More Information]

2005

  • Croisier, E., Moran, L., Dexter, D., Pearce, R., Graeber, M. (2005). Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. Journal of Neuroinflammation, 2, 14-1-14-8. [More Information]

2004

  • Duke, D., Moran, L., Turkheimer, F., Banati, R., Graeber, M. (2004). Microglia In Culture: What Genes Do They Express? Developmental Neuroscience, 26(1), 30-37.
  • Banati, R., Egensperger, R., Maassen, A., Hager, G., Kreutzberg, G., Graeber, M. (2004). Mitochondria in activated microglia in vitro. Journal of Neurocytology, 33(5), 353-541. [More Information]
  • Moran, L., Duke, D., Turkheimer, F., Banati, R., Graeber, M. (2004). Towards A Transcriptome Definition Of Microglial Cells. Neurogenetics, 5(2), 95-108. [More Information]

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