Dr Marian Fernandez

MSc MPhil PhD /Sr Research scientist, CREID, MBI, Westmead Institute of Medical Research/ Lecturer
Paediatrics &
Child Health, CPIR,KRI, Children'
s Hospital, Westmead

Telephone +61 2 86273445

Curriculum vitae Curriculum vitae

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Biographical details

Dr Marian Fernandez has recently joined the NHMRC Centre for Research Excellence in Protecting the Public from Emerging Infectious Diseases (CREID), Marie Bashir Institute for Infectious disease & Biosecurity (MBI) at WIMR. As the CREID Virology Genomicist, she will undertake a multicentre study of viral genome sequencing under the theme of pathogen emergence and spread withProf Edward C. Holmes and Prof Tania Sorrell.
Marian was awarded her PhD in the area of Molecular Genetics in 1996 and after her first post doc at the Victor Change Cardiac Research Institute moved to The Children's hospital at Westmead. Since then, she has actively contributed to both basic and clinical research in infection and immunity at Prof Cheryl Jones Lab at The Centre for Perinatal Infection Research, Kids Research Institute, CHW. She developed a unique murine model of neonatal and adult HSV infection and generated a series of major findings on the immunopathogenesis of HSV in collaboration with Prof Tony Cunningham, Centre for Viral research (WIMR) and Prof Stephen Alexander, Centre for Kidney research (CHW). She has presented her research at many nation and international conferences and as online journal publications.
 
In addition, Marian holds a Conjoint Lecturer position in Paediatrics & Child Health, Faculty of Medicine, University of Sydney since 2008, co-supervises many lab personnel including undergraduate, postgraduate and PhD students and has received awards for mentorship and teaching. She has been an active member of NSW scientific societies and a representative on many committees at the Westmead research hub.
 
Her current interest is in molecular epidemiology of infectious RNA viruses through the application of next-generation sequencing and state-of-the-art bioinformatics.

Clinical Specialty

Paediatrics

Selected grants

2011

  • TLR2 agonist - HIV peptide induction of TH17 reponses: a new immunotherapeutic and vaccine strategy; Cunningham A, Dyer W, Jones C, Fernandez M; Department of Health (Federal)/Targeted Prevention Programs.

Selected publications

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Journals

  • Diefenbach, R., Davis, A., Miranda Saksena, M., Fernandez, M., Kelly, B., Jones, C., LaVail, J., Xue, J., Lai, J., Cunningham, A. (2015). The basic domain of HSV-1 pUS9 recruits kinesin-1 to facilitate egress from neurons. Journal of Virology, 90(4), 2102-2111. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • Fernandez, M., YU, U., Zhang, G., White, R., Sparwasser, T., Alexander, S., Jones, C. (2013). Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology, 447(1-2), 9-20. [More Information]
  • Puttur, F., Fernandez, M., White, R., Roediger, B., Cunningham, A., Weninger, W., Jones, C. (2010). Herpes Simplex Virus Infects Skin {gamma} {delta} T Cells before Langerhans Cells and Impedes Migration of Infected Langerhans Cells by Inducing Apoptosis and Blocking E-Cadherin Downregulation. The Journal of Immunology, 185(1), 477-487. [More Information]
  • Fernandez, M., Evans, I., Hassan, E., Carbone, F., Jones, C. (2008). Neonatal CD8+ T cells are slow to develop into lytic effectors after HSV infection in vivo. European Journal of Immunology, 38(1), 102-113. [More Information]
  • Fernandez, M., Puttur, F., Wang, Y., Howden, W., Alexander, S., Jones, C. (2008). T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. The Journal of Immunology, 180(3), 1556-1564. [More Information]
  • Dall, T., Foellmi, C., Pritchard, J., Lo Curto, G., Prieto, C., Bruntt, H., Amado, P., Arentoft, T., Baes, M., Depagne, E., et al (2007). VSOP: the variable star one-shot project I. Project presentation and first data release. Astronomy and Astrophysics, 470(3), 1201-1214.
  • Jones, C., Fernandez, M., Herc, K., Bosnjak, L., Miranda Saksena, M., Boadle, R., Cunningham, A. (2003). Herpes Simplex virus type 2 inducses rapid cell death and functional impariment of murine dendritic cells invitro. Journal of Virology, 77(20), 11139-11149.

2015

  • Diefenbach, R., Davis, A., Miranda Saksena, M., Fernandez, M., Kelly, B., Jones, C., LaVail, J., Xue, J., Lai, J., Cunningham, A. (2015). The basic domain of HSV-1 pUS9 recruits kinesin-1 to facilitate egress from neurons. Journal of Virology, 90(4), 2102-2111. [More Information]

2013

  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • Fernandez, M., YU, U., Zhang, G., White, R., Sparwasser, T., Alexander, S., Jones, C. (2013). Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology, 447(1-2), 9-20. [More Information]

2010

  • Puttur, F., Fernandez, M., White, R., Roediger, B., Cunningham, A., Weninger, W., Jones, C. (2010). Herpes Simplex Virus Infects Skin {gamma} {delta} T Cells before Langerhans Cells and Impedes Migration of Infected Langerhans Cells by Inducing Apoptosis and Blocking E-Cadherin Downregulation. The Journal of Immunology, 185(1), 477-487. [More Information]

2008

  • Fernandez, M., Evans, I., Hassan, E., Carbone, F., Jones, C. (2008). Neonatal CD8+ T cells are slow to develop into lytic effectors after HSV infection in vivo. European Journal of Immunology, 38(1), 102-113. [More Information]
  • Fernandez, M., Puttur, F., Wang, Y., Howden, W., Alexander, S., Jones, C. (2008). T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. The Journal of Immunology, 180(3), 1556-1564. [More Information]

2007

  • Dall, T., Foellmi, C., Pritchard, J., Lo Curto, G., Prieto, C., Bruntt, H., Amado, P., Arentoft, T., Baes, M., Depagne, E., et al (2007). VSOP: the variable star one-shot project I. Project presentation and first data release. Astronomy and Astrophysics, 470(3), 1201-1214.

2003

  • Jones, C., Fernandez, M., Herc, K., Bosnjak, L., Miranda Saksena, M., Boadle, R., Cunningham, A. (2003). Herpes Simplex virus type 2 inducses rapid cell death and functional impariment of murine dendritic cells invitro. Journal of Virology, 77(20), 11139-11149.

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