Dr Andrea Markus

Honorary Associate
Physiology, School of Medical Sciences

Telephone +61 2 9351 4599
Fax +61 2 9351 2227

Map

Research interests

1. RNA processing, in particular alternative splicing, subcompartments of the nucleus and multifunctional RNA binding proteins.

2. Alternative splicing factors in disease, particularly cancer. 3. Genetics of longevity/cell aging and influence of polyphenols such as resveratrol.

International links

Germany

(Max Planck Institute for Biophysical Chemistry) Dr H. Oster, Rbm4 in circadian rhythm

Switzerland

(ETH Zurich) Prof. F. Allain, Structure of RBM4

United Kingdom

(Medical Research Council) Dr J. Ule, Search for RBM4 targets

Selected grants

2009

  • Genome-wide analysis of pre-mRNA splicing regulation by RBM4; Markus A, Morris B; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.

2004

  • Lark,a new splicing factor that binds WT1,may be involved in cancer; Markus A; University of Sydney/Cancer Research Fund.

Selected publications

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Journals

  • Yang, J., Markus, A., Mangs, A., Raitskin, O., Sperling, R., Morris, B. (2013). ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome. Molecular Biology Reports, 40(9), 5381-5395. [More Information]
  • Marques, F., Pringle, K., Conquest, A., Hirst, J., Markus, A., Sarris, M., Zakar, T., Morris, B., Lumbers, E. (2011). Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section. Placenta, 32(3), 214-221. [More Information]
  • Markus, A., Marques, F., Morris, B. (2011). Resveratrol, by Modulating RNA Processing Factor Levels, Can Influence the Alternative Splicing of Pre-mRNAs. PloS One, 6(12), e28926-1-e28926-7. [More Information]
  • Marques, F., Markus, A., Morris, B. (2010). Hormesis as a Pro-Healthy Aging Intervention in Human Beings? Dose-Response, 8(1), 28-33. [More Information]
  • Marques, F., Markus, A., Morris, B. (2010). The molecular basis of longevity, and clinical implications. Maturitas, 65(2), 87-91. [More Information]
  • Markus, A., Morris, B. (2009). RBM4: A multifunctional RNA-binding protein. The International Journal of Biochemistry and Cell Biology, 41(4), 740-743. [More Information]
  • Marques, F., Markus, A., Morris, B. (2009). Resveratrol: Cellular actions of a potent natural chemical that confers a diversity of health benefits. The International Journal of Biochemistry and Cell Biology, 41(11), 2125-2128. [More Information]
  • Martin, S., Markus, A., Morris, B., Davisson, R., Lawrence, A., van den Buuse, M. (2008). Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice? Neuropharmacology, 54(2), 399-404. [More Information]
  • Markus, A., Morris, B. (2008). Resveratrol in prevention and treatment of common clinical conditions of aging. Clinical Interventions in Aging, 3(2), 331-339. [More Information]
  • Markus, A., Goy, C., Adams, D., Lovicu, F., Morris, B. (2007). Renin Enhancer Is Crucial for Full Response in Renin Expression to an In Vivo Stimulus. Hypertension, 50, 933-938. [More Information]
  • Stefani, M., Markus, A., Lin, R., Pinese, M., Dawes, I., Morris, B. (2007). The Effect of Resveratrol on a Cell Model of Human Aging. New York Academy of Sciences. Annals, 1114, 407-418. [More Information]
  • Markus, A., Morris, B. (2006). Lark Is the Splicing Factor RBM4 and Exhibits Unique Subnuclear Localization Properties. DNA and Cell Biology, 25(8), 457-464. [More Information]
  • Adams, D., Head, G., Markus, A., Lovicu, F., Van Der Weyden, L., Köntgen, F., Arends, M., Thiru, S., Mayorov, D., Morris, B. (2006). Renin enhancer is critical for control of renin gene expression and cardiovascular function. Journal of Biological Chemistry, 281(42), 31753-31761. [More Information]
  • Markus, A., Heinrich, B., Raitskin, O., Adams, D., Mangs, A., Goy, C., Ladomery, M., Sperling, R., Stamm, S., Morris, B. (2006). WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Experimental Cell Research: emphasizing molecular approaches to cell biology, 312, 3379-3388. [More Information]
  • Mangs, A., Speirs, H., Goy, C., Adams, D., Markus, A., Morris, B. (2006). XE7: A novel splicing factor that interacts with ASF/SF2 and ZNF265. Nucleic Acids Research, 34(17), 4976-4986. [More Information]
  • Adams, D., van der Weyden, L., Gergely, F., Arends, M., Ng, B., Tannahill, D., Kanaar, R., Markus, A., Morris, B., Bradley, A. (2005). BRCTx is a novel, highly conserved RAD18-interacting protein. Molecular and Cellular Biology, 25(2), 779-788. [More Information]
  • Morris, B., Markus, A., Adams, D., Glenn, C., Colagiuri, S., Wang, X. (2002). Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes. Journal of Molecular Medicine, 80(2), 96-104. [More Information]
  • Cogger, V., Markus, A., Harvey, P., Ansselin, A., McLean, A., Le Couteur, D., Yin,, Z. (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33, 537-543.
  • Markus, A. (2001). Walter Benjamin or: The Commodity as Phantasmagoria. New German Critique: an interdisciplinary journal of German studies, 83, 3-42.

2013

  • Yang, J., Markus, A., Mangs, A., Raitskin, O., Sperling, R., Morris, B. (2013). ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome. Molecular Biology Reports, 40(9), 5381-5395. [More Information]

2011

  • Marques, F., Pringle, K., Conquest, A., Hirst, J., Markus, A., Sarris, M., Zakar, T., Morris, B., Lumbers, E. (2011). Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section. Placenta, 32(3), 214-221. [More Information]
  • Markus, A., Marques, F., Morris, B. (2011). Resveratrol, by Modulating RNA Processing Factor Levels, Can Influence the Alternative Splicing of Pre-mRNAs. PloS One, 6(12), e28926-1-e28926-7. [More Information]

2010

  • Marques, F., Markus, A., Morris, B. (2010). Hormesis as a Pro-Healthy Aging Intervention in Human Beings? Dose-Response, 8(1), 28-33. [More Information]
  • Marques, F., Markus, A., Morris, B. (2010). The molecular basis of longevity, and clinical implications. Maturitas, 65(2), 87-91. [More Information]

2009

  • Markus, A., Morris, B. (2009). RBM4: A multifunctional RNA-binding protein. The International Journal of Biochemistry and Cell Biology, 41(4), 740-743. [More Information]
  • Marques, F., Markus, A., Morris, B. (2009). Resveratrol: Cellular actions of a potent natural chemical that confers a diversity of health benefits. The International Journal of Biochemistry and Cell Biology, 41(11), 2125-2128. [More Information]

2008

  • Martin, S., Markus, A., Morris, B., Davisson, R., Lawrence, A., van den Buuse, M. (2008). Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice? Neuropharmacology, 54(2), 399-404. [More Information]
  • Markus, A., Morris, B. (2008). Resveratrol in prevention and treatment of common clinical conditions of aging. Clinical Interventions in Aging, 3(2), 331-339. [More Information]

2007

  • Markus, A., Goy, C., Adams, D., Lovicu, F., Morris, B. (2007). Renin Enhancer Is Crucial for Full Response in Renin Expression to an In Vivo Stimulus. Hypertension, 50, 933-938. [More Information]
  • Stefani, M., Markus, A., Lin, R., Pinese, M., Dawes, I., Morris, B. (2007). The Effect of Resveratrol on a Cell Model of Human Aging. New York Academy of Sciences. Annals, 1114, 407-418. [More Information]

2006

  • Markus, A., Morris, B. (2006). Lark Is the Splicing Factor RBM4 and Exhibits Unique Subnuclear Localization Properties. DNA and Cell Biology, 25(8), 457-464. [More Information]
  • Adams, D., Head, G., Markus, A., Lovicu, F., Van Der Weyden, L., Köntgen, F., Arends, M., Thiru, S., Mayorov, D., Morris, B. (2006). Renin enhancer is critical for control of renin gene expression and cardiovascular function. Journal of Biological Chemistry, 281(42), 31753-31761. [More Information]
  • Markus, A., Heinrich, B., Raitskin, O., Adams, D., Mangs, A., Goy, C., Ladomery, M., Sperling, R., Stamm, S., Morris, B. (2006). WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Experimental Cell Research: emphasizing molecular approaches to cell biology, 312, 3379-3388. [More Information]
  • Mangs, A., Speirs, H., Goy, C., Adams, D., Markus, A., Morris, B. (2006). XE7: A novel splicing factor that interacts with ASF/SF2 and ZNF265. Nucleic Acids Research, 34(17), 4976-4986. [More Information]

2005

  • Adams, D., van der Weyden, L., Gergely, F., Arends, M., Ng, B., Tannahill, D., Kanaar, R., Markus, A., Morris, B., Bradley, A. (2005). BRCTx is a novel, highly conserved RAD18-interacting protein. Molecular and Cellular Biology, 25(2), 779-788. [More Information]

2002

  • Morris, B., Markus, A., Adams, D., Glenn, C., Colagiuri, S., Wang, X. (2002). Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes. Journal of Molecular Medicine, 80(2), 96-104. [More Information]

2001

  • Cogger, V., Markus, A., Harvey, P., Ansselin, A., McLean, A., Le Couteur, D., Yin,, Z. (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33, 537-543.
  • Markus, A. (2001). Walter Benjamin or: The Commodity as Phantasmagoria. New German Critique: an interdisciplinary journal of German studies, 83, 3-42.

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