Professor Mark Connor

Honorary Professor
Pharmacology, School of Medical Sciences

Telephone +61 2 9812 3544
Fax +61 2 9812 3530

Map

Research interests

pharmacology, analgesia, cellular mechanisms in pain, opioids, vanilloid receptors

Selected grants

2011

  • The mechanisms responsible for tolerance at the mu-opioid receptor; Christie M, Connor M, Chieng B; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Mechanisms of serotonergic and triptan mediated analgesia within the midbrain; Vaughan C, Connor M, Jeong H; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Hidex Chameleon V Multi-Technology plate reader; Ittner L, Goetz J, MacDonald C, Kassiou M, Connor M, Holsinger D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Effects of muscle inflammation on sensory neuron excitability; Connor M, Vaughan C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Research Infrastructure (Major Equipment) Scheme 2008; Ittner L, Goetz J, Christie M, Bennett M, Kassiou M, Connor M, Holsinger D, Bagley E; Faculty of Medicine/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • A neuronal model for studying the regulation of serotonin receptors by anti-migraine drugs; Connor M, Cousins M; Australian and New Zealand College of Anaesthetists/Research Project Grant.
  • Real-time cellular imaging system; Connor M, Keast J, Vaughan C, Christie M, Osborne P, Bagley E, Sue C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Anandamide activated chloride channels in sensory neurons; Connor M, Christie M; Australian Research Council (ARC)/Discovery Projects (DP).
  • Cellular actions of drugs used to treat migraine; Connor M; University of Sydney/Bridging Support.

2006

  • Analysis Of Dental Pulp From Extracted Teeth To Identify Dental Pain Mechanisms; Vickers E, Connor M; ANZ Coll Anaesthetists (ANZCA)/Research Funding Scheme.
  • Molecular and cellular basis for the analgesic properties of N-arachidynyl amino acids; Vandenberg R, Connor M, Vaughan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Resurgent sodium currents in peripheral nerve axons and sensory neurones; Burke D, Connor M, Kiernan M; Australian Research Council (ARC)/Discovery Projects (DP).
  • Mechanism of action of drugs used to treat migraine; Connor M; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • Opioid actions on identified sensory neurons in vitro; Connor M; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Olympus FV300 confocal system plus assessories; Christie M, Vaughan C, Connor M, Keay K; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Arachidonic acid modulation of glutamate transporters; Vandenberg R, Connor M; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Opioid actions on sensory neuron excitability in vitro; Connor M; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Knapman, A., Santiago, M., Du, Y., Bennallack, P., Christie, M., Connor, M. (2013). A Continuous, Fluorescence-based Assay of u-Opioid Receptor Activation in AtT-20 Cells. Journal of Biomolecular Screening, 18(3), 269-276. [More Information]
  • Gilmore, A., Heblinski, M., Reynolds, A., Kassiou, M., Connor, M. (2012). Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT. British Journal of Pharmacology, 167(5), 1076-1088. [More Information]
  • Asghari Moghaddam, R., Lung, M., Pilowsky, P., Connor, M. (2011). Sex differences in the expression of serotonin-synthesizing enzymes in mouse trigeminal ganglia. Neuroscience, 199, 429-437. [More Information]
  • Fioretti, B., Catacuzzeno, L., Sforna, L., Gerke, M., van den Maagdenberg, A., Franciolini, F., Connor, M., Pietrobon, D. (2011). Trigeminal ganglion neuron subtype-specific alterations of CaV2.1 calcium current and excitability in a Cacna1a mouse model of migraine. The Journal of Physiology, 589(23), 5879-5895. [More Information]
  • Connor, M., Traynor, J. (2010). Constitutively Active μ-Opioid Receptors. Methods in Enzymology, 484(C), 445-469. [More Information]
  • Connor, M., Vaughan, C., Vandenberg, R. (2010). N-Acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets. British Journal of Pharmacology, 160(8), 1857-1871. [More Information]
  • Connor, M. (2009). Allopurinol for pain relief: more than just crystal clearance? British Journal of Pharmacology, 156(1), 4-6. [More Information]
  • Ross, H., Gilmore, A., Connor, M. (2009). Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine. British Journal of Pharmacology, 156(5), 740-750. [More Information]
  • Connor, M. (2009). Shadows across mu-Star? Constitutively active mu-opioid receptors revisited. British Journal of Pharmacology, 156(7), 1041-1043. [More Information]
  • Ross, H., Napier, I., Connor, M. (2008). Inhibition of recombinant human t-type calcium channels by delta 9-tetrahydrocannabinol and cannabidiol. Journal of Biological Chemistry. [More Information]
  • Roberts, L., Ross, H., Connor, M. (2008). Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. Neuropharmacology, 54(1), 172-180. [More Information]
  • Jeong, H., Chenu, D., Johnson, E., Connor, M., Vaughan, C. (2008). Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey. Molecular Pain, 4(54), 1-11. [More Information]
  • Edwards, M., Loxley, R., Williams, A., Connor, M., Phillips, J. (2007). Lack of functional expression of NMDA receptors in PC12 cells. NeuroToxicology, 28(4), 876-885. [More Information]
  • Johnson, E., Connor, M. (2007). Towards a Receptor for Nocistatin? British Journal of Pharmacology, 152, 415-6. [More Information]
  • Johnson, E., Chieng, B., Napier, I., Connor, M. (2006). Decreased mu-opioid receptor signalling and a reduction in calcium current density in sensory neurons from chronically morphine-treated mice. British Journal of Pharmacology, 148(7), 947-955. [More Information]
  • Connor, M., Kitchen, I. (2006). Has the sun set on kappa3-opioid receptors? British Journal of Pharmacology, 147(4), 349-50. [More Information]
  • Roberts, L., Connor, M. (2006). TRPV1 Antagonists as a Potential Treatment for Hyperalgesia. Recent Patents on C N S Drug Discovery, 1, 65-76. [More Information]
  • Connor, M., Naves, L., McCleskey, E. (2005). Contrasting phenotypes of putative proprioceptive and nociceptive trigeminal neurons innervating jaw muscle in rat. Molecular Pain, 1, 31-43. [More Information]
  • Marinelli, S., Connor, M., Schnell, S., Christie, M., Wessendorf, M., Vaughan, C. (2005). delta-OPIOID RECEPTOR-MEDIATED ACTIONS ON ROSTRAL VENTROMEDIAL MEDULLA NEURONS. Neuroscience, 132(2), 239-244. [More Information]
  • Connor, M., Vaughan, C. (2005). Humanizing mice: catching up with elusive B1 receptors. British Journal of Pharmacology, 144(7), 885-6. [More Information]
  • Bagley, E., Chieng, B., Christie, M., Connor, M. (2005). Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. British Journal of Pharmacology, 146(1), 68-76. [More Information]
  • Bailey, C., Connor, M. (2005). Opioids: cellular mechanisms of tolerance and physical dependence. Current Opinion in Pharmacology, 5(1), 60-68. [More Information]
  • Johnson, E., Christie, M., Connor, M. (2005). The Role of Opioid Receptor Phosphorylation and Trafficking in Adaptations to Persistent Opioid Treatment. NeuroSignals, 14(6), 290-302. [More Information]
  • Connor, M., Bagley, E., Mitchell, V., Ingram, S., Christie, M., Humphrey, P., Vaughan, C. (2004). Cellular Actions Of Somatostatin On Rat Periaqueductal Grey Neurons In Vitro. British Journal of Pharmacology, 142(8), 1273-1280.
  • Connor, M., Osborne, P., Christie, M. (2004). Mu-Opioid Receptor Desentization: Is Morphine Different? British Journal of Pharmacology, 143(6), 685-696.
  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Borgland, S., Connor, M., Osborne, P., Furness, J., Christie, M. (2003). Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization and endocytosis of Mu-opioid receptors. Journal of Biological Chemistry, 278(21), 18776-18784. [More Information]
  • Roberts, L., Christie, M., Connor, M. (2002). Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. British Journal of Pharmacology, 137(4), 421-428.
  • Marinelli, S., Vaughan, C., Christie, M., Connor, M. (2002). Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. The Journal of Physiology, 543(2), 531-540.
  • Dedov, V., Tran, V., Duke, C., Connor, M., Christie, M., Mandadi, S., Roufogalis, B. (2002). Gingerols: a novel class of vanilloid receptor (VR1) agonists. British Journal of Pharmacology, 137(6), 793-798.
  • Borgland, S., Connor, M., Ryan, R., Ball, H., Christie, M. (2002). Prostaglandin E2 inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. The Journal of Physiology, 539(2), 433-444.
  • Vaughan, C., Connor, M., Jennings, E., Marinelli, S., Christie, M., Allen, R. (2001). Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro. The Journal of Physiology, 534, 849-859.
  • Wang, X., Connor, M., Wilson, D., Wilson, H., Nicholson,, G., Smith, R., Shaw, D., Mackay, J., Alewood, P., Christie, M., et al (2001). Discovery and structure of a potent and highly specific blocker of insect calcium channels. Journal of Biological Chemistry, 276, 40306-40312.
  • Borgland, S., Connor, M., Christie, M. (2001). Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganlion neurons in mouse. The Journal of Physiology, 536, 35-47.

2013

  • Knapman, A., Santiago, M., Du, Y., Bennallack, P., Christie, M., Connor, M. (2013). A Continuous, Fluorescence-based Assay of u-Opioid Receptor Activation in AtT-20 Cells. Journal of Biomolecular Screening, 18(3), 269-276. [More Information]

2012

  • Gilmore, A., Heblinski, M., Reynolds, A., Kassiou, M., Connor, M. (2012). Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT. British Journal of Pharmacology, 167(5), 1076-1088. [More Information]

2011

  • Asghari Moghaddam, R., Lung, M., Pilowsky, P., Connor, M. (2011). Sex differences in the expression of serotonin-synthesizing enzymes in mouse trigeminal ganglia. Neuroscience, 199, 429-437. [More Information]
  • Fioretti, B., Catacuzzeno, L., Sforna, L., Gerke, M., van den Maagdenberg, A., Franciolini, F., Connor, M., Pietrobon, D. (2011). Trigeminal ganglion neuron subtype-specific alterations of CaV2.1 calcium current and excitability in a Cacna1a mouse model of migraine. The Journal of Physiology, 589(23), 5879-5895. [More Information]

2010

  • Connor, M., Traynor, J. (2010). Constitutively Active μ-Opioid Receptors. Methods in Enzymology, 484(C), 445-469. [More Information]
  • Connor, M., Vaughan, C., Vandenberg, R. (2010). N-Acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets. British Journal of Pharmacology, 160(8), 1857-1871. [More Information]

2009

  • Connor, M. (2009). Allopurinol for pain relief: more than just crystal clearance? British Journal of Pharmacology, 156(1), 4-6. [More Information]
  • Ross, H., Gilmore, A., Connor, M. (2009). Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine. British Journal of Pharmacology, 156(5), 740-750. [More Information]
  • Connor, M. (2009). Shadows across mu-Star? Constitutively active mu-opioid receptors revisited. British Journal of Pharmacology, 156(7), 1041-1043. [More Information]

2008

  • Ross, H., Napier, I., Connor, M. (2008). Inhibition of recombinant human t-type calcium channels by delta 9-tetrahydrocannabinol and cannabidiol. Journal of Biological Chemistry. [More Information]
  • Roberts, L., Ross, H., Connor, M. (2008). Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. Neuropharmacology, 54(1), 172-180. [More Information]
  • Jeong, H., Chenu, D., Johnson, E., Connor, M., Vaughan, C. (2008). Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey. Molecular Pain, 4(54), 1-11. [More Information]

2007

  • Edwards, M., Loxley, R., Williams, A., Connor, M., Phillips, J. (2007). Lack of functional expression of NMDA receptors in PC12 cells. NeuroToxicology, 28(4), 876-885. [More Information]
  • Johnson, E., Connor, M. (2007). Towards a Receptor for Nocistatin? British Journal of Pharmacology, 152, 415-6. [More Information]

2006

  • Johnson, E., Chieng, B., Napier, I., Connor, M. (2006). Decreased mu-opioid receptor signalling and a reduction in calcium current density in sensory neurons from chronically morphine-treated mice. British Journal of Pharmacology, 148(7), 947-955. [More Information]
  • Connor, M., Kitchen, I. (2006). Has the sun set on kappa3-opioid receptors? British Journal of Pharmacology, 147(4), 349-50. [More Information]
  • Roberts, L., Connor, M. (2006). TRPV1 Antagonists as a Potential Treatment for Hyperalgesia. Recent Patents on C N S Drug Discovery, 1, 65-76. [More Information]

2005

  • Connor, M., Naves, L., McCleskey, E. (2005). Contrasting phenotypes of putative proprioceptive and nociceptive trigeminal neurons innervating jaw muscle in rat. Molecular Pain, 1, 31-43. [More Information]
  • Marinelli, S., Connor, M., Schnell, S., Christie, M., Wessendorf, M., Vaughan, C. (2005). delta-OPIOID RECEPTOR-MEDIATED ACTIONS ON ROSTRAL VENTROMEDIAL MEDULLA NEURONS. Neuroscience, 132(2), 239-244. [More Information]
  • Connor, M., Vaughan, C. (2005). Humanizing mice: catching up with elusive B1 receptors. British Journal of Pharmacology, 144(7), 885-6. [More Information]
  • Bagley, E., Chieng, B., Christie, M., Connor, M. (2005). Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. British Journal of Pharmacology, 146(1), 68-76. [More Information]
  • Bailey, C., Connor, M. (2005). Opioids: cellular mechanisms of tolerance and physical dependence. Current Opinion in Pharmacology, 5(1), 60-68. [More Information]
  • Johnson, E., Christie, M., Connor, M. (2005). The Role of Opioid Receptor Phosphorylation and Trafficking in Adaptations to Persistent Opioid Treatment. NeuroSignals, 14(6), 290-302. [More Information]

2004

  • Connor, M., Bagley, E., Mitchell, V., Ingram, S., Christie, M., Humphrey, P., Vaughan, C. (2004). Cellular Actions Of Somatostatin On Rat Periaqueductal Grey Neurons In Vitro. British Journal of Pharmacology, 142(8), 1273-1280.
  • Connor, M., Osborne, P., Christie, M. (2004). Mu-Opioid Receptor Desentization: Is Morphine Different? British Journal of Pharmacology, 143(6), 685-696.

2003

  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Borgland, S., Connor, M., Osborne, P., Furness, J., Christie, M. (2003). Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization and endocytosis of Mu-opioid receptors. Journal of Biological Chemistry, 278(21), 18776-18784. [More Information]

2002

  • Roberts, L., Christie, M., Connor, M. (2002). Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. British Journal of Pharmacology, 137(4), 421-428.
  • Marinelli, S., Vaughan, C., Christie, M., Connor, M. (2002). Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. The Journal of Physiology, 543(2), 531-540.
  • Dedov, V., Tran, V., Duke, C., Connor, M., Christie, M., Mandadi, S., Roufogalis, B. (2002). Gingerols: a novel class of vanilloid receptor (VR1) agonists. British Journal of Pharmacology, 137(6), 793-798.
  • Borgland, S., Connor, M., Ryan, R., Ball, H., Christie, M. (2002). Prostaglandin E2 inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. The Journal of Physiology, 539(2), 433-444.

2001

  • Vaughan, C., Connor, M., Jennings, E., Marinelli, S., Christie, M., Allen, R. (2001). Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro. The Journal of Physiology, 534, 849-859.
  • Wang, X., Connor, M., Wilson, D., Wilson, H., Nicholson,, G., Smith, R., Shaw, D., Mackay, J., Alewood, P., Christie, M., et al (2001). Discovery and structure of a potent and highly specific blocker of insect calcium channels. Journal of Biological Chemistry, 276, 40306-40312.
  • Borgland, S., Connor, M., Christie, M. (2001). Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganlion neurons in mouse. The Journal of Physiology, 536, 35-47.

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