Associate Professor Martin Krause

Clinical Associate Professor
Medicine, Northern Clinical School

Telephone +61 2 9463 1733
Fax +61 2 9463 1071

Website Northern Sydney Neurology
Curriculum vitae Curriculum vitae

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Biographical details

Dr Martin Krause received his medical degree from one of the most prestigious and oldest Medical Schools in the world - the University of Heidelberg, which was founded in 1386.

He started his training in Neurology in 1995 at the Neurology Department of the University Hospitals Heidelberg, Germany under the mentorship of Prof Werner Hacke a world leader in stroke therapy.

He finalized his medical these and received the Dr. Med. with magna cum laude on the topic of diagnostic accuracy of telemedicine and picture archiving and communication systems in 1997.

Dr Krause’s main focus of research was initially movement disorders. He was so fortunate to work together with the neurosurgeon Prof Volker Tronnier. Dr Tronnier was a pioneer of functional neurosurgery and deep brain stimulation (DBS). This research group explored DBS for dystonia which proved to be the first effective therapy in generalized dystonia. Dr Krause was founding member of the German Parkinson Competence Network, which linked clinical research institutions in Europe together and enabled large-scale clinical trials. In this group the first randomized controlled trial of DBS proved the effectiveness of DBS for Parkinson’s disease and different types of dystonia.

He had extensive training in neurophysiology and Botox therapy under the mentorship of Prof HM Meinck who had a special interest in stiff-man disease and functional disorders. Dr Krause was accredited as board certified neurophysiologist in 2001.

He further engaged in 2 years of neuro-critical care training in the largest neurological Intensive Care Unit.

Very early on Dr Krause was involved in acute stroke treatment and participated in all three ECASS trials, which led to the first effective therapy for acute stroke. He completed his training with neurovascular ultrasound training in 2005.

Following the comprehensive German specialist exit exam Dr Krause was registered as board certified Neurologists and Neurophysiologist in 2005.

He represented over 1000 physicians and surgeons in Heidelberg in the staff council. He was part of a small group negotiating new employment terms for doctors abandoning 36 hours shifts and standardizing training streams.

In 2007 Dr Krause accepted an offer as Associated Professor of Medicine by the University of Sydney as a full time medical academic. He was part of the Nepean Clinical School. He furthered the acute stroke service in Nepean Hospital and introduced transcranial ultrasound to diagnostic repertoire of neurovascular ultrasound in Nepean.

In 2011 Dr Krause was appointed as Stroke Unit Head in Royal North Shore Hospital and Neuroscience Director for the Northern Sydney Local Health District.

In 2015 he was appointed Head of Department of Neurology at Royal North Shore Hospital.

He has authored 45 peer-reviewed publications of which three were in the prestigious New England Journal of Medicine.

He has received numerous prizes for his work both nationally and internationally and is a frequent presenter at national and international conference and scientific meetings.

Dr Krause is a member of the strategic working party of the Agency of Clinical Innovation and the State-wide Stroke Service. He is a member of the Stroke Society of Australasia and the Stroke Research Network.

He is a member of the American Heart Association, the German Society of Neurology as well as the Australian New-Zealand Association of Neurologists.

Research interests

Acute Stroke Therapy

Stroke Imaging

Stroke Prevention

Movement Disorders

Dystonia

Parkinson Disease

Behavioural Neurology

Teaching and supervision

Stroke

Movement Disorders

Parkinson Disease

Tremors

Dystonia

Behavioural Neurology

Neurocritical Care

Status epilepticus

Functional Disorders

Clinical Specialty

Neurology

Selected grants

2010

  • Impulse control disorders and quality of life in Parkinsons Disease; Krause M; Nepean Medical Research Foundation/Project Grant.

2008

  • Impulse Control Disorders and Quality of Life; Krause M, Starcevic V; Parkinson's New South Wales Incorporated/Research Support.

Selected publications

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Journals

  • Campbell, B., Mitchell, P., Yan, B., Parsons, M., Christensen, S., Churilov, L., Dowling, R., Dewey, H., Brooks, M., Miteff, F., Krause, M., et al (2014). A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological De�?cits with Intra-Arterial therapy (EXTEND-IA). International Journal of Stroke, 9(1), 126-132. [More Information]
  • Adam, R., Priglinger, M., Harrington, T., Gottlieb, D., Krause, M. (2014). An Unusual Cause of Cerebellar Hemorrhage in a Young Patient: Essential Thrombocythemia. Journal of Stroke and Cerebrovascular Diseases, 23(5), e373-e374. [More Information]
  • Phu, A., Xu, Z., Brakoulias, V., Mahant, N., Fung, V., De Moore, G., Martin, A., Starcevic, V., Krause, M. (2014). Effect of impulse control disorders on disability and quality of life in Parkinson's disease patients. Journal of Clinical Neuroscience, 21(1), 63-66. [More Information]
  • Ma, C., Evans, K., Bertmar, C., Krause, M. (2014). Predictive value of the Royal Melbourne Hospital Falls Risk Assessment Tool (RMH FRAT) for post-stroke patients. Journal of Clinical Neuroscience, 21(4), 607-611. [More Information]
  • Griffiths, D., Newey, A., Faulder, K., Steinfort, B., Krause, M. (2013). Thrombosis of a Developmental Venous Anomaly Causing Venous Infarction and Pontine Hemorrhage. Journal of Stroke and Cerebrovascular Diseases, 22(8), e653-655. [More Information]
  • Ma, H., Parsons, M., Christensen, S., Campbell, B., Churilov, L., Connelly, A., Yan, B., Bladin, C., Phan, T., Barber, A., Krause, M., et al (2012). A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND). International Journal of Stroke, 7(1), 74-80. [More Information]
  • Krause, M., Mahant, N., Kotschet, K., Fung, V., Vagg, D., Wong, C., Morris, J. (2012). Dysexecutive behaviour following deep brain lesions - A different type of disconnection syndrome? Cortex, 48(1), 97-119. [More Information]
  • Volkmann, J., Wolters, A., Kupsch, A., Muller, J., Kuhn, A., Schneider, G., Poewe, W., Hering, S., Eisner, W., Muller, J., Krause, M., et al (2012). Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial. The Lancet Neurology, 11(12), 1029-1038. [More Information]
  • Sandercock, P., Wardlaw, J., Lindley, R., Dennis, M., Cohen, G., Murray, G., Innes, K., Venables, G., Czlonkowska, A., Kobayashi, A., et al (2012). The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. The Lancet, 379(9834), 2352-2363. [More Information]
  • Sandercock, P., Lindley, R., Wardlaw, J., Dennis, M., Innes, K., Cohen, G., Whiteley, W., Perry, D., Soosay, V., Buchanan, D., et al (2011). Update on the third international stroke trial (IST- 3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited. Trials, 12(252), 1-9. [More Information]
  • Daniels, C., Krack, P., Volkmann, J., Pinsker, M., Krause, M., Tronnier, V., Kloss, M., Schnitzler, A., Wojtecki, L., Bötzel, K., et al (2010). Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease. Movement Disorders, 25(11), 1583-1589. [More Information]
  • Witt, K., Daniels, C., Reiff, J., Krack, P., Volkmann, J., Pinsker, M., Krause, M., Tronnier, V., Schnitzler, A., Hilker, R., et al (2008). Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study. The Lancet Neurology, 7(7), 605-614. [More Information]
  • Mueller, J., Skogseid, I., Benecke, R., Volkmann, J., Kupsch, A., Trottenberg, T., Poewe, W., Schnitzler, A., Krause, M., Brentrup, A., et al (2008). Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial. Movement Disorders, 23(1), 131-134. [More Information]
  • Szabo, K., Hirsch, J., Krause, M., Ende, G., Henn, F., Sartorius, A., Gass, A. (2007). Diffusion weighted MRI in the early phase after electroconvulsive therapy. Neurological research, 29(3), 256-259. [More Information]
  • Henninger, N., Wang, Q., Okun, J., Schwab, S., Krause, M. (2007). Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats. Parkinsonism and Related Disorders, 13(8), 524-527. [More Information]
  • Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J., Schäfer, H., Bötzel, K., Daniels, C., Deutschländer, A., Dillmann, U., Krause, M., et al (2006). A randomized trial of deep-brain stimulation for Parkinson's disease. New England Journal of Medicine, 355(9), 896-908. [More Information]
  • Lubik, S., Fogel, W., Tronnier, V., Krause, M., König, J., Jost, W. (2006). Gait analysis in patients with advanced Parkinson disease: different or additive effects on gait induced by levodopa and chronic STN stimulation. Journal of Neural Transmission, 113(2), 163-173. [More Information]
  • Krause, M., Fogel, W., Tronnier, V., Pohle, S., Hörtnagel, K., Thyen, U., Volkmann, J. (2006). Long-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration. Movement Disorders, 21(12), 2255-2257. [More Information]
  • Kupsch, A., Benecke, R., Müller, J., Trottenberg, T., Schneider, G., Poewe, W., Eisner, W., Wolters, A., Krause, M., et al (2006). Pallidal deep-brain stimulation in primary generalized or segmental dystonia. New England Journal of Medicine, 355(19), 1978-1990. [More Information]
  • Krause, M., Fogel, W., Mayer, P., Kloss, M., Tronnier, V. (2004). Chronic inhibition of the subthalamic nucleus in Parkinson's disease. Journal of the Neurological Sciences, 219(1-2), 119-124. [More Information]
  • Schroeder, U., Kuehler, A., Hennenlotter, A., Haslinger, B., Tronnier, V., Krause, M., Pfister, R., Sprengelmeyer, R., Lange, K., Ceballos-Baumann, A. (2004). Facial expression recognition and subthalamic nucleus stimulation. Journal of Neurology, Neurosurgery and Psychiatry, 75(4), 648-650.
  • Krause, M., Fogel, W., Kloss, M., Rasche, D., Volkmann, J., Tronnier, V. (2004). Pallidal stimulation for dystonia. Neurosurgery, 55(6), 1361-1368.
  • Veltkamp, R., Krause, M., Schranz, C., Meinck, H. (2003). Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. Muscle and Nerve, 28(2), 242-245. [More Information]
  • Schroeder, U., Kuehler, A., Lange, K., Haslinger, B., Tronnier, V., Krause, M., Pfister, R., Boecker, H., Ceballos-Baumann, A. (2003). Subthalamic nucleus stimulation affects a frontotemporal network: a PET study. Annals of Neurology, 54(4), 445-450. [More Information]

2014

  • Campbell, B., Mitchell, P., Yan, B., Parsons, M., Christensen, S., Churilov, L., Dowling, R., Dewey, H., Brooks, M., Miteff, F., Krause, M., et al (2014). A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological De�?cits with Intra-Arterial therapy (EXTEND-IA). International Journal of Stroke, 9(1), 126-132. [More Information]
  • Adam, R., Priglinger, M., Harrington, T., Gottlieb, D., Krause, M. (2014). An Unusual Cause of Cerebellar Hemorrhage in a Young Patient: Essential Thrombocythemia. Journal of Stroke and Cerebrovascular Diseases, 23(5), e373-e374. [More Information]
  • Phu, A., Xu, Z., Brakoulias, V., Mahant, N., Fung, V., De Moore, G., Martin, A., Starcevic, V., Krause, M. (2014). Effect of impulse control disorders on disability and quality of life in Parkinson's disease patients. Journal of Clinical Neuroscience, 21(1), 63-66. [More Information]
  • Ma, C., Evans, K., Bertmar, C., Krause, M. (2014). Predictive value of the Royal Melbourne Hospital Falls Risk Assessment Tool (RMH FRAT) for post-stroke patients. Journal of Clinical Neuroscience, 21(4), 607-611. [More Information]

2013

  • Griffiths, D., Newey, A., Faulder, K., Steinfort, B., Krause, M. (2013). Thrombosis of a Developmental Venous Anomaly Causing Venous Infarction and Pontine Hemorrhage. Journal of Stroke and Cerebrovascular Diseases, 22(8), e653-655. [More Information]

2012

  • Ma, H., Parsons, M., Christensen, S., Campbell, B., Churilov, L., Connelly, A., Yan, B., Bladin, C., Phan, T., Barber, A., Krause, M., et al (2012). A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND). International Journal of Stroke, 7(1), 74-80. [More Information]
  • Krause, M., Mahant, N., Kotschet, K., Fung, V., Vagg, D., Wong, C., Morris, J. (2012). Dysexecutive behaviour following deep brain lesions - A different type of disconnection syndrome? Cortex, 48(1), 97-119. [More Information]
  • Volkmann, J., Wolters, A., Kupsch, A., Muller, J., Kuhn, A., Schneider, G., Poewe, W., Hering, S., Eisner, W., Muller, J., Krause, M., et al (2012). Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial. The Lancet Neurology, 11(12), 1029-1038. [More Information]
  • Sandercock, P., Wardlaw, J., Lindley, R., Dennis, M., Cohen, G., Murray, G., Innes, K., Venables, G., Czlonkowska, A., Kobayashi, A., et al (2012). The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. The Lancet, 379(9834), 2352-2363. [More Information]

2011

  • Sandercock, P., Lindley, R., Wardlaw, J., Dennis, M., Innes, K., Cohen, G., Whiteley, W., Perry, D., Soosay, V., Buchanan, D., et al (2011). Update on the third international stroke trial (IST- 3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited. Trials, 12(252), 1-9. [More Information]

2010

  • Daniels, C., Krack, P., Volkmann, J., Pinsker, M., Krause, M., Tronnier, V., Kloss, M., Schnitzler, A., Wojtecki, L., Bötzel, K., et al (2010). Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease. Movement Disorders, 25(11), 1583-1589. [More Information]

2008

  • Witt, K., Daniels, C., Reiff, J., Krack, P., Volkmann, J., Pinsker, M., Krause, M., Tronnier, V., Schnitzler, A., Hilker, R., et al (2008). Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study. The Lancet Neurology, 7(7), 605-614. [More Information]
  • Mueller, J., Skogseid, I., Benecke, R., Volkmann, J., Kupsch, A., Trottenberg, T., Poewe, W., Schnitzler, A., Krause, M., Brentrup, A., et al (2008). Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial. Movement Disorders, 23(1), 131-134. [More Information]

2007

  • Szabo, K., Hirsch, J., Krause, M., Ende, G., Henn, F., Sartorius, A., Gass, A. (2007). Diffusion weighted MRI in the early phase after electroconvulsive therapy. Neurological research, 29(3), 256-259. [More Information]
  • Henninger, N., Wang, Q., Okun, J., Schwab, S., Krause, M. (2007). Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats. Parkinsonism and Related Disorders, 13(8), 524-527. [More Information]

2006

  • Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J., Schäfer, H., Bötzel, K., Daniels, C., Deutschländer, A., Dillmann, U., Krause, M., et al (2006). A randomized trial of deep-brain stimulation for Parkinson's disease. New England Journal of Medicine, 355(9), 896-908. [More Information]
  • Lubik, S., Fogel, W., Tronnier, V., Krause, M., König, J., Jost, W. (2006). Gait analysis in patients with advanced Parkinson disease: different or additive effects on gait induced by levodopa and chronic STN stimulation. Journal of Neural Transmission, 113(2), 163-173. [More Information]
  • Krause, M., Fogel, W., Tronnier, V., Pohle, S., Hörtnagel, K., Thyen, U., Volkmann, J. (2006). Long-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration. Movement Disorders, 21(12), 2255-2257. [More Information]
  • Kupsch, A., Benecke, R., Müller, J., Trottenberg, T., Schneider, G., Poewe, W., Eisner, W., Wolters, A., Krause, M., et al (2006). Pallidal deep-brain stimulation in primary generalized or segmental dystonia. New England Journal of Medicine, 355(19), 1978-1990. [More Information]

2004

  • Krause, M., Fogel, W., Mayer, P., Kloss, M., Tronnier, V. (2004). Chronic inhibition of the subthalamic nucleus in Parkinson's disease. Journal of the Neurological Sciences, 219(1-2), 119-124. [More Information]
  • Schroeder, U., Kuehler, A., Hennenlotter, A., Haslinger, B., Tronnier, V., Krause, M., Pfister, R., Sprengelmeyer, R., Lange, K., Ceballos-Baumann, A. (2004). Facial expression recognition and subthalamic nucleus stimulation. Journal of Neurology, Neurosurgery and Psychiatry, 75(4), 648-650.
  • Krause, M., Fogel, W., Kloss, M., Rasche, D., Volkmann, J., Tronnier, V. (2004). Pallidal stimulation for dystonia. Neurosurgery, 55(6), 1361-1368.

2003

  • Veltkamp, R., Krause, M., Schranz, C., Meinck, H. (2003). Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. Muscle and Nerve, 28(2), 242-245. [More Information]
  • Schroeder, U., Kuehler, A., Lange, K., Haslinger, B., Tronnier, V., Krause, M., Pfister, R., Boecker, H., Ceballos-Baumann, A. (2003). Subthalamic nucleus stimulation affects a frontotemporal network: a PET study. Annals of Neurology, 54(4), 445-450. [More Information]

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