Dr Masaomi Kato

Honorary Associate
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6236

Curriculum vitae Curriculum vitae

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Biographical details

Group Leader, The Laboratory of Ageing, Centenary Institute, Sydney – 2012-present

Postdoctoral Fellow / Associate Research Scientist, Yale University, USA – 2006-2012

Postdoctoral Fellow, National Institute of Genetics, Japan – 2005-2006

PhD: The Graduate University for Advanced Studies and National Institute of Genetics, Japan - 2005

Research interests

The long-term goal of our work is to understand genetic machineries involved in ageing processes, including metabolism and age-associated disorders. We are using the nematode C. elegans, which provides an ideal system for studying the molecular biology of ageing with its relatively short lifespan, powerful genetics and genetic conservation. We are currently focusing on the following projects:

1. Role of microRNA-involved genetic machineries in stress response and dietary restriction-mediated lifespan extension.

2. Mechanisms controlling a homeostasis regulator FOXO and their role in ageing.

Selected grants

2013

  • MicroRNA-Mediated Genetic Regulation of Ageing; Kato M; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Kato, M., Slack, F. (2013). Ageing and the small, non-coding RNA world. Ageing research reviews, 12(1), 429-435. [More Information]
  • Kato, M., Chen, X., Inukai, S., Zhao, H., Slack, F. (2011). Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA, 17(10), 1804-1820. [More Information]
  • Cheng, C., Yan, K., Hwang, W., Qian, J., Bhardwaj, N., Rozowsky, J., Lu, Z., Niu, W., Alves, P., Kato, M., et al (2011). Construction and analysis of an integrated regulatory network derived from high-throughput sequencing data. PLoS Computational Biology, 7(11), e1002190-e1002190. [More Information]
  • Lu, Z., Yip, K., Wang, G., Hillier, L., Shou, C., Khurana, E., Agarwal, A., Auerbach, R., Rozowsky, J., Cheng, C., et al (2011). Prediction and characterization of noncoding RNAs in C. elegans by integrating conservation, secondary structure, and high-throughput sequencing and array data. Genome Research, 21(2), 276-285. [More Information]
  • Gerstein, M., Lu, Z., Van Nostrand, E., Cheng, C., Arshinoff, B., Liu, T., Yip, K., Robilotto, R., Rechtsteiner, A., Ikegami, K., et al (2010). Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science, 330(6012), 1775-1787. [More Information]
  • de Lencastre, A., Pincus, Z., Zhou, K., Kato, M., Lee, S., Slack, F. (2010). MicroRNAs both promote and antagonize longevity in C. elegans. Current Biology, 20(24), 2159-2168. [More Information]
  • Kato, M., de Lencastre, A., Pincus, Z., Slack, F. (2009). Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biology, 10(5), R54-R54. [More Information]
  • Kato, M., Paranjape, T., Ullrich, R., Nallur, S., Gillespie, E., Esquela-Kerscher, A., Weidhaas, J., Slack, F., Keane, K. (2009). The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells. Oncogene, 28(25), 2419-2424. [More Information]
  • Kato, M., Slack, F. (2008). microRNAs: small molecules with big roles - C. elegans to human cancer. Biology of the Cell, 100(2), 71-81. [More Information]
  • Ono, T., Kaya, H., Takeda, S., Abe, M., Ogawa, Y., Kakutani, T., Kato, M., Mittelsten Scheid, O., Araki, T., Shibahara, K. (2006). Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis. Genes to Cells, 11(2), 153-162. [More Information]

2013

  • Kato, M., Slack, F. (2013). Ageing and the small, non-coding RNA world. Ageing research reviews, 12(1), 429-435. [More Information]

2011

  • Kato, M., Chen, X., Inukai, S., Zhao, H., Slack, F. (2011). Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA, 17(10), 1804-1820. [More Information]
  • Cheng, C., Yan, K., Hwang, W., Qian, J., Bhardwaj, N., Rozowsky, J., Lu, Z., Niu, W., Alves, P., Kato, M., et al (2011). Construction and analysis of an integrated regulatory network derived from high-throughput sequencing data. PLoS Computational Biology, 7(11), e1002190-e1002190. [More Information]
  • Lu, Z., Yip, K., Wang, G., Hillier, L., Shou, C., Khurana, E., Agarwal, A., Auerbach, R., Rozowsky, J., Cheng, C., et al (2011). Prediction and characterization of noncoding RNAs in C. elegans by integrating conservation, secondary structure, and high-throughput sequencing and array data. Genome Research, 21(2), 276-285. [More Information]

2010

  • Gerstein, M., Lu, Z., Van Nostrand, E., Cheng, C., Arshinoff, B., Liu, T., Yip, K., Robilotto, R., Rechtsteiner, A., Ikegami, K., et al (2010). Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science, 330(6012), 1775-1787. [More Information]
  • de Lencastre, A., Pincus, Z., Zhou, K., Kato, M., Lee, S., Slack, F. (2010). MicroRNAs both promote and antagonize longevity in C. elegans. Current Biology, 20(24), 2159-2168. [More Information]

2009

  • Kato, M., de Lencastre, A., Pincus, Z., Slack, F. (2009). Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biology, 10(5), R54-R54. [More Information]
  • Kato, M., Paranjape, T., Ullrich, R., Nallur, S., Gillespie, E., Esquela-Kerscher, A., Weidhaas, J., Slack, F., Keane, K. (2009). The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells. Oncogene, 28(25), 2419-2424. [More Information]

2008

  • Kato, M., Slack, F. (2008). microRNAs: small molecules with big roles - C. elegans to human cancer. Biology of the Cell, 100(2), 71-81. [More Information]

2006

  • Ono, T., Kaya, H., Takeda, S., Abe, M., Ogawa, Y., Kakutani, T., Kato, M., Mittelsten Scheid, O., Araki, T., Shibahara, K. (2006). Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis. Genes to Cells, 11(2), 153-162. [More Information]

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