Dr Maté Biro

BSc(Hons) ARCS MSc DIC PhD

EMBL Australia Group Leader

EMBL Australia node in Single Molecule Science
The University of New South Wales
Level 3, Lowy Cancer Research Centre
Sydney, NSW 2052, Australia
Email: m.biro [at] unsw.edu.au

Honorary Associate
Sydney Medical School


Telephone +61 293 858 020
Fax +61 293 851 389
Website Biro Group website
Curriculum vitae Curriculum vitae

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Biographical details

Dr. Biro obtained his PhD at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, in 2011 with summa cum laude.

He has previously worked at the Bioinformatics Institute of A*STAR in Singapore, at the MIT BioImaging Center in Cambridge, MA, USA and at the KEK: High Energy Accelerator Research Organisation in Tsukuba, Japan.

Dr. Biro has a passion for flying all things powered or unpowered, and discovering the marvels of the underwater world whilst diving. He is also always happy to discuss his research and other interests over a beer...

Research interests

Dr. Biro's research focuses on the role of the actomyosin cell cortex in driving:

1) the migration of cancer cells during tumour escape and tissue invasion,

2) the migration of cytotoxic T cells in the solid tumour microenvironment, and,

3) the mechanics of intercellular interactions between cytotoxic T cells and their target tumour cells.

He uses an interdisciplinary approach encompassing cell biology, biophysics, immunology, bioimage informatics and advanced light microscopy.

Current projects

PhD/Masters projects are available in either of the 3 lines of investigations summarised above for competitive students that have the potential to secure a scholarship.

Please contact Dr. Biro directly or via Research Supervisor Connect for further information.

Associations

Associate Investigator, ARC Centre of Excellence for Advanced Molecular Imaging

Board Member of the Alliance for Design and Application in Tissue Engineering (ADATE)

Member of the Biophysical Society, USA

Member of the Australian Society for Biophysics

Member of Sydney Catalyst: the Translational Cancer Research Centre of Central Sydney and Regional NSW

Member of the Cancer Research Network of The University of Sydney

PhD and master's project opportunities

International links

Germany

(EMBL: European Molecular Biology Laboratory) Collaboration on the implementation and application of biophysical tools for the measurement of cytoskeletal dynamics and cellular mechanics

Germany

(Max Planck Institute of Molecular Cell Biology and Genetics) Collaboration on analysis of cellular actin cortex dynamics and quantitative image analysis solutions

Singapore

(Institute of Molecular and Cell Biology) Collaboration on development of 4D image analysis solutions for cell migration

United Kingdom

(London Centre for Nanotechnology) Collaboration on analysis of cellular actin cortex dynamics and quantitative image analysis solutions

United States

(Stanford University) Collaboration on the application of unsupervised clustering to gene expression data

United States

(University of Texas at Austin) Collaboration on the analysis of actin cortex oscillations in dividing cells

Selected grants

2015

  • Portable Infrared Spectroscopy Equipment for Cancer Diagnosis, Research into Prevention of Cancer by Understanding the Role of Diet, and for Drug Development and Studies on Efficacy; Lay P, Richardson D, Banati R, Biro M, Bebawy M, Graeber M, Grau G, Hambley T, New E, Carter E; Cancer Institute New South Wales/Equipment Grant.
  • Cancer invasion and metastasis: how actin networks control cell movement in 3 dimensional environments; O'Neill G, Biro M, Dehghani F, Chrzanowski W, Richardson D; DVC Research/SPARC Implementation - Cancer.

2014

  • The role of cellular protrusions and the actomyosin cortex in invasive tumour cell migration; Biro M; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.
  • Mechanobiology of cellular protrusions and the actomyosin cortex in invasive tumour cell migration; Biro M; Cancer Institute New South Wales/Early Career Fellowship.

2013

  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Book Chapters

  • Biro, M., Maitre, J. (2015). Dual pipette aspiration: A unique tool for studying intercellular adhesion. In Ewa K. Paluch (Eds.), Methods in Cell Biology: Biophysical Methods in Cell Biology, (pp. 255-267). London: Academic Press. [More Information]

Journals

  • Galeano Nino, J., Kwan, R., Weninger, W., Biro, M. (2016). Antigen-specific T cells fully conserve antitumour function following cryopreservation. Immunology and Cell Biology, 94(4), 411-418. [More Information]
  • Sedzinski, J., Hannezo, E., Tu, F., Biro, M., Wallingford, J. (2016). Emergence of an Apical Epithelial Cell Surface In Vivo. Developmental Cell, 36(1), 24-35. [More Information]
  • Newman, P., Lu, Z., Roohaniesfahani, S., Church, T., Biro, M., Davies, B., King, A., MacKenzie, K., Minett, A., Zreiqat, H. (2015). Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering. Journal of Materials Chemistry B, 3(42), 8337-8347. [More Information]
  • Tong, P., Roediger, B., Kolesnikoff, N., Biro, M., Tay, S., Jain, R., Shaw, L., Grimbaldeston, M., Weninger, W. (2015). The Skin Immune Atlas: Three-Dimensional Analysis of Cutaneous Leukocyte Subsets by Multiphoton Microscopy. Journal of Investigative Dermatology, 135(1), 84-93. [More Information]
  • Bovellan, M., Romeo, Y., Biro, M., Boden, A., Chugh, P., Yonis, A., Vaghela, M., Fritzsche, M., Moulding, D., Thorogate, R., et al (2014). Cellular Control of Cortical Actin Nucleation. Current Biology, 24, 1628-1635. [More Information]
  • Weninger, W., Biro, M., Jain, R. (2014). Leukocyte migration in the interstitial space of non-lymphoid organs. Nature Reviews Immunology, 14(4), 232-246. [More Information]
  • Munoz, M., Biro, M., Weninger, W. (2014). T cell migration in intact lymph nodes in vivo. Current Opinion in Cell Biology, 30, 17-24. [More Information]
  • Biro, M., Munoz, M., Weninger, W. (2014). Targeting Rho-GTPases in immune cell migration and inflammation. British Journal of Pharmacology, 171(24), 5491-5506. [More Information]
  • Biro, M., Romeo, Y., Kroschwald, S., Bovellan, M., Boden, A., Tcherkezian, J., Roux, P., Charras, G., Paluch, E. (2013). Cell Cortex Composition and Homeostasis Resolved by Integrating Proteomics and Quantitative Imaging. Cytoskeleton, 70(11), 741-754. [More Information]
  • Sedzinski, J., Biro, M., Oswald, A., Tinevez, J., Salbreux, G., Paluch, E. (2011). Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature, 476(7361), 462-468. [More Information]
  • Biro, M., Puah, W., Cheok, L., Ng, W., Wasser, M. (2011). TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis. BioTechniques, 51(1), 49-54. [More Information]

2016

  • Galeano Nino, J., Kwan, R., Weninger, W., Biro, M. (2016). Antigen-specific T cells fully conserve antitumour function following cryopreservation. Immunology and Cell Biology, 94(4), 411-418. [More Information]
  • Sedzinski, J., Hannezo, E., Tu, F., Biro, M., Wallingford, J. (2016). Emergence of an Apical Epithelial Cell Surface In Vivo. Developmental Cell, 36(1), 24-35. [More Information]

2015

  • Biro, M., Maitre, J. (2015). Dual pipette aspiration: A unique tool for studying intercellular adhesion. In Ewa K. Paluch (Eds.), Methods in Cell Biology: Biophysical Methods in Cell Biology, (pp. 255-267). London: Academic Press. [More Information]
  • Newman, P., Lu, Z., Roohaniesfahani, S., Church, T., Biro, M., Davies, B., King, A., MacKenzie, K., Minett, A., Zreiqat, H. (2015). Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering. Journal of Materials Chemistry B, 3(42), 8337-8347. [More Information]
  • Tong, P., Roediger, B., Kolesnikoff, N., Biro, M., Tay, S., Jain, R., Shaw, L., Grimbaldeston, M., Weninger, W. (2015). The Skin Immune Atlas: Three-Dimensional Analysis of Cutaneous Leukocyte Subsets by Multiphoton Microscopy. Journal of Investigative Dermatology, 135(1), 84-93. [More Information]

2014

  • Bovellan, M., Romeo, Y., Biro, M., Boden, A., Chugh, P., Yonis, A., Vaghela, M., Fritzsche, M., Moulding, D., Thorogate, R., et al (2014). Cellular Control of Cortical Actin Nucleation. Current Biology, 24, 1628-1635. [More Information]
  • Weninger, W., Biro, M., Jain, R. (2014). Leukocyte migration in the interstitial space of non-lymphoid organs. Nature Reviews Immunology, 14(4), 232-246. [More Information]
  • Munoz, M., Biro, M., Weninger, W. (2014). T cell migration in intact lymph nodes in vivo. Current Opinion in Cell Biology, 30, 17-24. [More Information]
  • Biro, M., Munoz, M., Weninger, W. (2014). Targeting Rho-GTPases in immune cell migration and inflammation. British Journal of Pharmacology, 171(24), 5491-5506. [More Information]

2013

  • Biro, M., Romeo, Y., Kroschwald, S., Bovellan, M., Boden, A., Tcherkezian, J., Roux, P., Charras, G., Paluch, E. (2013). Cell Cortex Composition and Homeostasis Resolved by Integrating Proteomics and Quantitative Imaging. Cytoskeleton, 70(11), 741-754. [More Information]

2011

  • Sedzinski, J., Biro, M., Oswald, A., Tinevez, J., Salbreux, G., Paluch, E. (2011). Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature, 476(7361), 462-468. [More Information]
  • Biro, M., Puah, W., Cheok, L., Ng, W., Wasser, M. (2011). TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis. BioTechniques, 51(1), 49-54. [More Information]

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