Dr Maté Biro

BSc (Hons) MSc PhD
Head of Cellular Mechanobiology
Immune Imaging Program
Centenary Institute of Cancer Medicine & Cell Biology

Honorary Associate
Sydney Medical School

Telephone +61 2 9565 6249
Fax +61 2 9565 6101

Website Professional website
Curriculum vitae Curriculum vitae

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Biographical details

Dr. Biro obtained his PhD at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, in 2011 with summa cum laude.

He has previously worked at the Bioinformatics Institute of A*STAR in Singapore, at the MIT BioImaging Center in Cambridge, MA, USA and at the KEK: High Energy Accelerator Research Organisation in Tsukuba, Japan.

Dr. Biro has a passion for flying all things powered or unpowered, and discovering the marvels of the underwater world whilst diving. He is also always happy to discuss his research and other interests over a beer...

Research interests

Dr. Biro's research focuses on the role of the actomyosin cell cortex in driving:

1) the migration of cancer cells during tumour escape and tissue invasion,

2) the migration of cytotoxic T cells in the solid tumour microenvironment, and,

3) the mechanics of intercellular interactions between cytotoxic T cells and their target tumour cells.

He uses an interdisciplinary approach encompassing cell biology, biophysics, immunology, bioimage informatics and advanced light microscopy.

Current projects

PhD/Masters projects are available in either of the 3 lines of investigations summarised above for competitive students that have the potential to secure a scholarship.

Please contact Dr. Biro directly or via Research Supervisor Connect for further information.

Associations

Board Member of the Alliance for Design and Application in Tissue Engineering (ADATE)

Member of the Biophysical Society, USA

Member of the Australian Society for Biophysics

Member of Sydney Catalyst: the Translational Cancer Research Centre of Central Sydney and Regional NSW

Member of the Cancer Research Network of The University of Sydney

PhD and master's project opportunities

International links

Germany

(EMBL: European Molecular Biology Laboratory) Collaboration on the implementation and application of biophysical tools for the measurement of cytoskeletal dynamics and cellular mechanics

Germany

(Max Planck Institute of Molecular Cell Biology and Genetics) Collaboration on analysis of cellular actin cortex dynamics and quantitative image analysis solutions

Singapore

(Institute of Molecular and Cell Biology) Collaboration on development of 4D image analysis solutions for cell migration

United Kingdom

(London Centre for Nanotechnology) Collaboration on analysis of cellular actin cortex dynamics and quantitative image analysis solutions

United States

(Stanford University) Collaboration on the application of unsupervised clustering to gene expression data

United States

(University of Texas at Austin) Collaboration on the analysis of actin cortex oscillations in dividing cells

Selected grants

2014

  • The role of cellular protrusions and the actomyosin cortex in invasive tumour cell migration; Biro M; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.
  • Mechanobiology of cellular protrusions and the actomyosin cortex in invasive tumour cell migration; Biro M; Cancer Institute New South Wales/Early Career Development Fellowship.

2013

  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Journals

  • Weninger, W., Biro, M., Jain, R. (2014). Leukocyte migration in the interstitial space of non-lymphoid organs. Nature Reviews Immunology, 14(4), 232-246. [More Information]
  • Biro, M., Romeo, Y., Kroschwald, S., Bovellan, M., Boden, A., Tcherkezian, J., Roux, P., Charras, G., Paluch, E. (2013). Cell Cortex Composition and Homeostasis Resolved by Integrating Proteomics and Quantitative Imaging. Cytoskeleton, 70(11), 741-754. [More Information]
  • Sedzinski, J., Biro, M., Oswald, A., Tinevez, J., Salbreux, G., Paluch, E. (2011). Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature, 476(7361), 462-468. [More Information]
  • Biro, M., Puah, W., Cheok, L., Ng, W., Wasser, M. (2011). TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis. BioTechniques: the journal of laboratory technology for bioresearch, 51(1), 49-54. [More Information]

2014

  • Weninger, W., Biro, M., Jain, R. (2014). Leukocyte migration in the interstitial space of non-lymphoid organs. Nature Reviews Immunology, 14(4), 232-246. [More Information]

2013

  • Biro, M., Romeo, Y., Kroschwald, S., Bovellan, M., Boden, A., Tcherkezian, J., Roux, P., Charras, G., Paluch, E. (2013). Cell Cortex Composition and Homeostasis Resolved by Integrating Proteomics and Quantitative Imaging. Cytoskeleton, 70(11), 741-754. [More Information]

2011

  • Sedzinski, J., Biro, M., Oswald, A., Tinevez, J., Salbreux, G., Paluch, E. (2011). Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature, 476(7361), 462-468. [More Information]
  • Biro, M., Puah, W., Cheok, L., Ng, W., Wasser, M. (2011). TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis. BioTechniques: the journal of laboratory technology for bioresearch, 51(1), 49-54. [More Information]

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