Professor Mathew Vadas

AO, FAHMS
Executive Director, Centenary Institute of Cancer Medicine & Cell Biology
Professor of Medicine, University of Sydney, Central Clinical School

Telephone +61 2 9565 6135

Website Centenary Institute

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Biographical details

Professor Mathew Vadas is a physician and internationally renowned immunologist who leads a program of vascular research focused on the mechanisms of inflammation in endothelial cells and on the resultant impact of inflammation on endothelial function in various disease states. His program of drug discovery research uses multidisciplinary biotechnological approaches to uncover novel cellular signaling pathways or molecules involved in endothelial inflammation with the objective of developing new therapeutics. He is the Executive Director of the Centenary Institute, Sydney. Professor Vadas has established major research enterprises in Australia. He was founder and inaugural Director of the Hanson Centre for Cancer Research (now the Hanson Institute). He also was involved in establishing two ASX-listed biotechnology companies and consults to the Australian biotechnology sector. Professor Vadas is one Australia’s most highly cited scientists with >25,500 citations (H index = 85). He is an Inaugural (2001) ISI Award Citation Laureate (one of 33 most cited Australian researchers in all disciplines). His work has made seminal contributions to medical science. His early research implicating TNF-alpha inhibitors in endothelial activation (which in turn promotes endothelial inflammation), was the first description of endothelial activation as a necessary precursor in inflammation and spawned the modern-day TNF-alpha inhibitor drugs that are commonly used to manage inflammatory conditions such as rheumatoid arthritis. Professor Vadas is Board Member of Sydney Catalyst, and of the Institute for Creative Health and on the research advisory committee of ACRF. He is an inaugural Fellow of the Australian Academy of Health and Medical Sciences (AAHMS). In 2012, he was awarded Officer of the Order of Australia (AO) "for distinguished service to medical and biotechnological research, particularly in the area of human immunology, to higher education, and through contributions to professional organisations”.

Research interests

Professor Vadas leads a broad program of mechanistic and drug discovery research conducted in collaboration with Professor Jennifer Gamble as part of the Vascular Research program at the Centenary Institute. Together they lead a team of scientists who are using techniques in cell and molecular biology, biochemistry, bioinformatics and genomics to study mechanisms involved in endothelial inflammation in various disease states, with the aim of identifying new anti-inflammatory molecular targets. His team has helped define the role of sphingosine kinase and the role of microRNAs in the endothelial inflammatory process. Professor Vadas was the first to identify sphingosine kinase as a normal gene that behaves as an oncogene (phenomenon of non-oncogene addiction). Many of his laboratory’s discoveries have been patented.

Currently his team is developing microRNAs-based therapeutics and evaluating their use to aid re-formation of cellular junctions in endothelial cells to limit damage/aid recovery after arterial blockage. The use of microRNAs for the treatment of eye disease and cancer also is being assessed. In addition, Professor Vadas’ team has identified a gene that functions as the ‘guardian of vascular integrity’. The gene, which is implicated in the normal alignment of the vascular endothelium, plays an atheroprotective role. Ongoing studies are attempting to further understand this process and to find molecules that may interact with or inhibit this gene and alter its atheroprotective function. Other areas of research focus include studies on the molecular determinants of endothelial cell senescence.

Selected grants

2013

  • Normalisation of tumour angiogenic vessels by a novel miRNA inhibitor; Gamble J, Vadas M; University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding.
  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas de St Groth B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • miRNAs and Cardiovascular Disease; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.

2011

  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Senescence and Cardiovascular Disease; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.

2010

  • High speed 3D live cell imaging of cancer genesis, growth, metastasis and death.; Weninger W, Vadas M, Richardson D, Fazekas de St Groth B, Gamble J, McCaughan G, Rasko J, Shackel N, Haass N; Cancer Institute New South Wales/Equipment Grant.
  • Super-resolution fluorescence microscopy; Gaus K, Gandevia S, King N, Allen D, Vadas M, Ammit A, Grewal T, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Inflammation, Angiogenesis and Cancer; Vadas M, McCaughan G, Gamble J, Bertolino P, Xia P; National Health and Medical Research Council (NHMRC)/Program Grants.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Manager imaging and cytometry and imaging specialist for expanded Centenary Insttute flow and imaging facility; Vadas M; Cancer Institute New South Wales/Infrastructure Grant.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • How Age Influences Blood Vessel Function; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.
  • 7-laser BD LSR-II and Cellomics Array Scan VTi to Enhance Capability and Throughput for the NSW Advanced Cytometry Facility; King N, Weninger W, Gunning P, Fazekas de St Groth B, Campbell I, Christopherson R, Black J, Mason R, Richardson D, Halliday G, Grau G, Gandevia S, Kachigian L, Geczy C, Jessup W, Vadas M, Britton W, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas de St Groth B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.

2008

  • Development of Inhibitors of PKCzeta for Targeting Vascular Leak; Parker M, Gamble J, Vadas M, Parker M; National Health and Medical Research Council (NHMRC)/Career Development Awards.
  • Leucocyte and endtherlial cell biology; Vadas M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • 800 MHz NMR spectrometer for biomolecular structure-function analysis; Mackay J, Otting G, Kuchel P, Matthews J, Gell D, Trewhella J, Rutledge P, Messerle B, Vadas M, Graham R, Vandenberg J, Stock D, Ball G, Fazekas de St Groth B, Shine J; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • 800 MHz NMR spectrometer for biomolecular structure function analysis; Vadas M, Stock D, Graham R, Shine J, Ball G, Matthews J, Gell D, Trewhella J, Rutledge P, Messerle B, Fazekas de St Groth B, Vandenberg J, Mackay J, Otting G, Kuchel P; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • Centenary centre for genomic medicine: Cancer genomics gene discovery platform; Vadas M; Cancer Institute New South Wales/Research Grant.

Selected publications

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Journals

  • Powter, E., Coleman, P., Tran, M., Lay, A., Bertolino, P., Parton, R., Vadas, M., Gamble, J. (2015). Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. Aging Cell, 14(1), 102-111. [More Information]
  • Chang, G., Lay, A., Ting, K., Zhao, Y., Coleman, P., Powter, E., Formaz-Preston, A., Jolly, C., Bower, N., Hogan, B., Rinkwitz, S., Becker, T., Vadas, M., Gamble, J. (2014). ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. Small GTPases, 5(3), 1-15. [More Information]
  • Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]
  • Lichtenstein, I., Charleston, M., Caetano, T., Gamble, J., Vadas, M. (2013). Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies. BMC Bioinformatics, 14, 1-22. [More Information]
  • Coleman, P., Chang, G., Hutas Attila, G., Grimshaw, M., Vadas, M., Gamble, J. (2013). Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging, 5(12), 913-924.
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]
  • Gamble, J., Vadas, M., McCaughan, G. (2011). Sinusoidal endothelium is essential for liver regeneration. Hepatology, 54(2), 731-733. [More Information]
  • Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., Khew-Goodall, Y. (2010). A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration. Journal of Immunology, 185(5), 3057-3063. [More Information]
  • Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., Beck, K., Stocker, R., Vadas, M., Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. [More Information]
  • Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 424-441. [More Information]
  • Gamble, J., Vadas, M. (2009). Insights into defibrotide as therapy for veno-occlusive disease. Hepatology, 49(2), 689-690. [More Information]
  • Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., Imhof, B., Vadas, M., Gamble, J. (2009). JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of beta 3 Integrins. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(8), 1200-1206. [More Information]
  • Sukocheva, O., Wang, L., Verrier, E., Vadas, M., Xia, P. (2009). Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology, 150(10), 4484-4492. [More Information]
  • Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., Pitson, S., Lopez, A., Coates, P., Proia, R., Vadas, M., Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. [More Information]
  • Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., Bonder, C. (2009). Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. The American Journal of Pathology: cellular and molecular biology of disease, 175(5), 2217-2225. [More Information]
  • Limaye, V., Vadas, M., Pitson, S., Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 411-423. [More Information]
  • Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., Xia, P., Proia, R., Vadas, M., Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497. [More Information]
  • Leclercq, T., Moretti, P., Vadas, M., Pitson, S. (2008). Eukaryotic Elongation Factor 1A Interacts with Sphingosine Kinase and Directly Enhances Its Catalytic Activity. Journal of Biological Chemistry, 283(15), 9606-9614. [More Information]
  • Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., Vadas, M., Khew-Goodall, Y., Goodall, G. (2008). The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601. [More Information]
  • Vadas, M., Xia, P., McCaughan, G., Gamble, J. (2008). The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction? BBA - Bioenergetics, 1781 (9), 442-447. [More Information]
  • Soldi, R., Mandinova, A., Venkataraman, K., Hla, T., Vadas, M., Pitson, S., Duarte, M., Graziani, I., Kolev, V., Kacer, D., et al (2007). Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research, 313(15), 3308-3318. [More Information]
  • Bert, A., Grepin, R., Vadas, M., Goodall, G. (2006). Assessing IRES activity in the HIF-1α and other cellular 5′ UTRs. RNA, 12(6), 1074-1083. [More Information]
  • Sukocheva, O., Wadham, C., Holmes, A., Albanese, N., Verrier, E., Feng, F., Bernal, A., Derian, C., Ullrich, A., Vadas, M., Xia, P. (2006). Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. The Journal of Cell Biology, 173(2), 301-310. [More Information]
  • Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. [More Information]
  • Hissaria, P., Smith, W., Wormald, P., Taylor, J., Vadas, M., Gillis, D., Kette, F. (2006). Short course of systemic corticosteroids in sinonasal polyposis: A double-blind, randomized, placebo-controlled trial with evaluation of outcome measures. Journal of Allergy and Clinical Immunology, 118(1), 128-133. [More Information]
  • Sutherland, C., Moretti, P., Hewitt, N., Bagley, C., Vadas, M., Pitson, S. (2006). The Calmodulin-binding Site of Sphingosine Kinase and Its Role in Agonist-dependent Translocation of Sphingosine Kinase 1 to the Plasma Membrane. Journal of Biological Chemistry, 281(17), 11693-11701. [More Information]
  • Autelitano, D., Rajic, A., Smith, A., Berndt, M., Ilag, L., Vadas, M. (2006). The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities. Drug Discovery Today, 11(7/8), 306-314. [More Information]
  • Wang, L., Xing, X., Holmes, A., Wadham, C., Gamble, J., Vadas, M., Xia, P. (2005). Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells. Circulation Research, 97, 891-899. [More Information]
  • Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., Yu, S., Kremmidiotis, G., Gardner, A., Solomon, P., Vadas, M., Gamble, J., et al (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(-), 57-69. [More Information]
  • Coles, L., Lambrusco, L., Burrows, J., Hunter, J., Diamond, P., Bert, A., Vadas, M., Goodall, G. (2005). Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3β and repression of the human VEGF promoter. FEBS Letters, 579(24), 5372-5378. [More Information]
  • Pitson, S., Xia, P., Leclercq, T., Moretti, P., Zebol, J., Lynn, H., Wattenberg, B., Vadas, M. (2005). Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. The Journal of Experimental Medicine, 201(1), 49-54. [More Information]
  • Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. [More Information]
  • Coles, L., Bartley, M., Bert, A., Hunter, J., Polyak, S., Diamond, P., Vadas, M., Goodall, G. (2004). A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA: Potential role in mRNA stabilization. European Journal of Biochemistry, 271(3), 648-660.
  • Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., Kremmidiotis, G., Vadas, M., Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 101(33), 12212-12217.
  • Roberts, J., Moretti, P., Darrow, A., Derian, C., Vadas, M., Pitson, S. (2004). An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Analytical Biochemistry, 331(1), 122-129. [More Information]
  • Wadham, C., Albanese, N., Roberts, J., Wang, L., Bagley, C., Gamble, J., Rye, K., Barter, P., Vadas, M., Xia, P. (2004). High-Density Lipoproteins Neutralize C-Reactive Protein Proinflammatory Activity. Circulation, 109(17), 2116-2122. [More Information]
  • Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., Chatterjee, K., Vadas, M., Xia, P. (2004). PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase. Circulation Research, 94(11), 1515-1522.
  • Thomas, D., Vadas, M., Lopez, A. (2004). Regulation of haematopoiesis by growth factors - Emerging insights and therapies. Expert Opinion on Biological Therapy, 4(6), 869-879.
  • Li, X., Hahn, C., Parsons, M., Drew, J., Vadas, M., Gamble, J. (2004). Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood, 104(6), 1716-1724.
  • Stein, B., Gamble, J., Pitson, S., Vadas, M., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. Journal of Immunology, 171(11), 6097-6104.
  • Pitson, S., Moretti, P., Zebol, J., Lynn, H., Xia, P., Vadas, M., Wattenberg, B. (2003). Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. The EMBO Journal, 22(20), 5491-5500.
  • Imhof, B., Vadas, M. (2003). New therapeutic targets in vascular biology. Thrombosis and Haemostasis, 90(4), 557-559.
  • Sukocheva, O., Wang, L., Albanese, N., Pitson, S., Vadas, M., Xia, P. (2003). Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells. Molecular Endocrinology, 17(10), 2002-2012.
  • Wadham, C., Gamble, J., Vadas, M., Khew-Goodall, Y. (2003). The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates β-catenin. Molecular Biology of the Cell, 14(6), 2520-2529.
  • Gamble, J., Drew, J., Trezise, L., Underwood, A., Parsons, M., Parsons, M., Kasminkas, K., Rudge, J., Yancopoulos, G., Vadas, M. (2000). Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circulation Research, 87(7), 603-607.

2015

  • Powter, E., Coleman, P., Tran, M., Lay, A., Bertolino, P., Parton, R., Vadas, M., Gamble, J. (2015). Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. Aging Cell, 14(1), 102-111. [More Information]

2014

  • Chang, G., Lay, A., Ting, K., Zhao, Y., Coleman, P., Powter, E., Formaz-Preston, A., Jolly, C., Bower, N., Hogan, B., Rinkwitz, S., Becker, T., Vadas, M., Gamble, J. (2014). ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. Small GTPases, 5(3), 1-15. [More Information]
  • Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]

2013

  • Lichtenstein, I., Charleston, M., Caetano, T., Gamble, J., Vadas, M. (2013). Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies. BMC Bioinformatics, 14, 1-22. [More Information]
  • Coleman, P., Chang, G., Hutas Attila, G., Grimshaw, M., Vadas, M., Gamble, J. (2013). Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging, 5(12), 913-924.
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]

2011

  • Gamble, J., Vadas, M., McCaughan, G. (2011). Sinusoidal endothelium is essential for liver regeneration. Hepatology, 54(2), 731-733. [More Information]

2010

  • Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., Khew-Goodall, Y. (2010). A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration. Journal of Immunology, 185(5), 3057-3063. [More Information]
  • Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., Beck, K., Stocker, R., Vadas, M., Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. [More Information]

2009

  • Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 424-441. [More Information]
  • Gamble, J., Vadas, M. (2009). Insights into defibrotide as therapy for veno-occlusive disease. Hepatology, 49(2), 689-690. [More Information]
  • Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., Imhof, B., Vadas, M., Gamble, J. (2009). JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of beta 3 Integrins. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(8), 1200-1206. [More Information]
  • Sukocheva, O., Wang, L., Verrier, E., Vadas, M., Xia, P. (2009). Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology, 150(10), 4484-4492. [More Information]
  • Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., Pitson, S., Lopez, A., Coates, P., Proia, R., Vadas, M., Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. [More Information]
  • Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., Bonder, C. (2009). Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. The American Journal of Pathology: cellular and molecular biology of disease, 175(5), 2217-2225. [More Information]
  • Limaye, V., Vadas, M., Pitson, S., Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 411-423. [More Information]

2008

  • Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., Xia, P., Proia, R., Vadas, M., Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497. [More Information]
  • Leclercq, T., Moretti, P., Vadas, M., Pitson, S. (2008). Eukaryotic Elongation Factor 1A Interacts with Sphingosine Kinase and Directly Enhances Its Catalytic Activity. Journal of Biological Chemistry, 283(15), 9606-9614. [More Information]
  • Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., Vadas, M., Khew-Goodall, Y., Goodall, G. (2008). The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601. [More Information]
  • Vadas, M., Xia, P., McCaughan, G., Gamble, J. (2008). The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction? BBA - Bioenergetics, 1781 (9), 442-447. [More Information]

2007

  • Soldi, R., Mandinova, A., Venkataraman, K., Hla, T., Vadas, M., Pitson, S., Duarte, M., Graziani, I., Kolev, V., Kacer, D., et al (2007). Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research, 313(15), 3308-3318. [More Information]

2006

  • Bert, A., Grepin, R., Vadas, M., Goodall, G. (2006). Assessing IRES activity in the HIF-1α and other cellular 5′ UTRs. RNA, 12(6), 1074-1083. [More Information]
  • Sukocheva, O., Wadham, C., Holmes, A., Albanese, N., Verrier, E., Feng, F., Bernal, A., Derian, C., Ullrich, A., Vadas, M., Xia, P. (2006). Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. The Journal of Cell Biology, 173(2), 301-310. [More Information]
  • Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. [More Information]
  • Hissaria, P., Smith, W., Wormald, P., Taylor, J., Vadas, M., Gillis, D., Kette, F. (2006). Short course of systemic corticosteroids in sinonasal polyposis: A double-blind, randomized, placebo-controlled trial with evaluation of outcome measures. Journal of Allergy and Clinical Immunology, 118(1), 128-133. [More Information]
  • Sutherland, C., Moretti, P., Hewitt, N., Bagley, C., Vadas, M., Pitson, S. (2006). The Calmodulin-binding Site of Sphingosine Kinase and Its Role in Agonist-dependent Translocation of Sphingosine Kinase 1 to the Plasma Membrane. Journal of Biological Chemistry, 281(17), 11693-11701. [More Information]
  • Autelitano, D., Rajic, A., Smith, A., Berndt, M., Ilag, L., Vadas, M. (2006). The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities. Drug Discovery Today, 11(7/8), 306-314. [More Information]

2005

  • Wang, L., Xing, X., Holmes, A., Wadham, C., Gamble, J., Vadas, M., Xia, P. (2005). Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells. Circulation Research, 97, 891-899. [More Information]
  • Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., Yu, S., Kremmidiotis, G., Gardner, A., Solomon, P., Vadas, M., Gamble, J., et al (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(-), 57-69. [More Information]
  • Coles, L., Lambrusco, L., Burrows, J., Hunter, J., Diamond, P., Bert, A., Vadas, M., Goodall, G. (2005). Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3β and repression of the human VEGF promoter. FEBS Letters, 579(24), 5372-5378. [More Information]
  • Pitson, S., Xia, P., Leclercq, T., Moretti, P., Zebol, J., Lynn, H., Wattenberg, B., Vadas, M. (2005). Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. The Journal of Experimental Medicine, 201(1), 49-54. [More Information]
  • Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. [More Information]

2004

  • Coles, L., Bartley, M., Bert, A., Hunter, J., Polyak, S., Diamond, P., Vadas, M., Goodall, G. (2004). A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA: Potential role in mRNA stabilization. European Journal of Biochemistry, 271(3), 648-660.
  • Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., Kremmidiotis, G., Vadas, M., Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 101(33), 12212-12217.
  • Roberts, J., Moretti, P., Darrow, A., Derian, C., Vadas, M., Pitson, S. (2004). An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Analytical Biochemistry, 331(1), 122-129. [More Information]
  • Wadham, C., Albanese, N., Roberts, J., Wang, L., Bagley, C., Gamble, J., Rye, K., Barter, P., Vadas, M., Xia, P. (2004). High-Density Lipoproteins Neutralize C-Reactive Protein Proinflammatory Activity. Circulation, 109(17), 2116-2122. [More Information]
  • Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., Chatterjee, K., Vadas, M., Xia, P. (2004). PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase. Circulation Research, 94(11), 1515-1522.
  • Thomas, D., Vadas, M., Lopez, A. (2004). Regulation of haematopoiesis by growth factors - Emerging insights and therapies. Expert Opinion on Biological Therapy, 4(6), 869-879.
  • Li, X., Hahn, C., Parsons, M., Drew, J., Vadas, M., Gamble, J. (2004). Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood, 104(6), 1716-1724.

2003

  • Stein, B., Gamble, J., Pitson, S., Vadas, M., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. Journal of Immunology, 171(11), 6097-6104.
  • Pitson, S., Moretti, P., Zebol, J., Lynn, H., Xia, P., Vadas, M., Wattenberg, B. (2003). Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. The EMBO Journal, 22(20), 5491-5500.
  • Imhof, B., Vadas, M. (2003). New therapeutic targets in vascular biology. Thrombosis and Haemostasis, 90(4), 557-559.
  • Sukocheva, O., Wang, L., Albanese, N., Pitson, S., Vadas, M., Xia, P. (2003). Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells. Molecular Endocrinology, 17(10), 2002-2012.
  • Wadham, C., Gamble, J., Vadas, M., Khew-Goodall, Y. (2003). The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates β-catenin. Molecular Biology of the Cell, 14(6), 2520-2529.

2000

  • Gamble, J., Drew, J., Trezise, L., Underwood, A., Parsons, M., Parsons, M., Kasminkas, K., Rudge, J., Yancopoulos, G., Vadas, M. (2000). Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circulation Research, 87(7), 603-607.

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