Professor Mathew Vadas

AO
Executive Director & Professor
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6135

Website Related website

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Selected grants

2013

  • Normalisation of tumour angiogenic vessels by a novel miRNA inhibitor; Gamble J, Vadas M; Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding.
  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas de St Groth B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • miRNAs and Cardiovascular Disease; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.

2011

  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Senescence and Cardiovascular Disease; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.

2010

  • High speed 3D live cell imaging of cancer genesis, growth, metastasis and death.; Weninger W, Vadas M, Richardson D, Fazekas de St Groth B, Gamble J, McCaughan G, Rasko J, Shackel N, Haass N; Cancer Institute New South Wales/Equipment Grant.
  • Super-resolution fluorescence microscopy; Gaus K, Gandevia S, King N, Allen D, Vadas M, Ammit A, Grewal T, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Inflammation, Angiogenesis and Cancer; Vadas M, McCaughan G, Gamble J, Bertolino P, Xia P; National Health and Medical Research Council (NHMRC)/Program Grants.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Manager imaging and cytometry and imaging specialist for expanded Centenary Insttute flow and imaging facility; Vadas M; Cancer Institute New South Wales/Infrastructure Grant.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • How Age Influences Blood Vessel Function; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.
  • 7-laser BD LSR-II and Cellomics Array Scan VTi to Enhance Capability and Throughput for the NSW Advanced Cytometry Facility; King N, Weninger W, Gunning P, Fazekas de St Groth B, Campbell I, Christopherson R, Black J, Mason R, Richardson D, Halliday G, Grau G, Gandevia S, Kachigian L, Geczy C, Jessup W, Vadas M, Britton W, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas de St Groth B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.

2008

  • Development of Inhibitors of PKCzeta for Targeting Vascular Leak; Parker M, Gamble J, Vadas M, Parker M; National Health and Medical Research Council (NHMRC)/Career Development Awards.
  • Leucocyte and endtherlial cell biology; Vadas M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • 800 MHz NMR spectrometer for biomolecular structure-function analysis; Mackay J, Otting G, Kuchel P, Matthews J, Gell D, Trewhella J, Rutledge P, Messerle B, Vadas M, Graham R, Vandenberg J, Stock D, Ball G, Fazekas de St Groth B, Shine J; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • 800 MHz NMR spectrometer for biomolecular structure function analysis; Vadas M, Stock D, Graham R, Shine J, Ball G, Matthews J, Gell D, Trewhella J, Rutledge P, Messerle B, Fazekas de St Groth B, Vandenberg J, Mackay J, Otting G, Kuchel P; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • Centenary centre for genomic medicine: Cancer genomics gene discovery platform; Vadas M; Cancer Institute New South Wales/Research Grant.

Selected publications

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Journals

  • Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]
  • Lichtenstein, I., Charleston, M., Caetano, T., Gamble, J., Vadas, M. (2013). Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies. BMC Bioinformatics, 14, 1-22. [More Information]
  • Coleman, P., Chang, G., Hutas Attila, G., Grimshaw, M., Vadas, M., Gamble, J. (2013). Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging, 5(12), 913-924.
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]
  • Gamble, J., Vadas, M., McCaughan, G. (2011). Sinusoidal endothelium is essential for liver regeneration. Hepatology, 54(2), 731-733. [More Information]
  • Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., Khew-Goodall, Y. (2010). A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration. Journal of Immunology, 185(5), 3057-3063. [More Information]
  • Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., Beck, K., Stocker, R., Vadas, M., Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. [More Information]
  • Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 424-441. [More Information]
  • Gamble, J., Vadas, M. (2009). Insights into defibrotide as therapy for veno-occlusive disease. Hepatology, 49(2), 689-690. [More Information]
  • Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., Imhof, B., Vadas, M., Gamble, J. (2009). JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of beta 3 Integrins. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(8), 1200-1206. [More Information]
  • Sukocheva, O., Wang, L., Verrier, E., Vadas, M., Xia, P. (2009). Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology, 150(10), 4484-4492. [More Information]
  • Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., Pitson, S., Lopez, A., Coates, P., Proia, R., Vadas, M., Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. [More Information]
  • Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., Bonder, C. (2009). Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. The American Journal of Pathology: cellular and molecular biology of disease, 175(5), 2217-2225. [More Information]
  • Limaye, V., Vadas, M., Pitson, S., Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 411-423. [More Information]
  • Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., Xia, P., Proia, R., Vadas, M., Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497.
  • Leclercq, T., Moretti, P., Vadas, M., Pitson, S. (2008). Eukaryotic Elongation Factor 1A Interacts with Sphingosine Kinase and Directly Enhances Its Catalytic Activity. Journal of Biological Chemistry, 283(15), 9606-9614. [More Information]
  • Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., Vadas, M., Khew-Goodall, Y., Goodall, G. (2008). The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601. [More Information]
  • Vadas, M., Xia, P., McCaughan, G., Gamble, J. (2008). The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction? BBA - Bioenergetics, 1781 (9), 442-447. [More Information]
  • Soldi, R., Mandinova, A., Venkataraman, K., Hla, T., Vadas, M., Pitson, S., Duarte, M., Graziani, I., Kolev, V., Kacer, D., et al (2007). Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research: emphasizing molecular approaches to cell biology, 313(15), 3308-3318. [More Information]
  • Bert, A., Grepin, R., Vadas, M., Goodall, G. (2006). Assessing IRES activity in the HIF-1α and other cellular 5′ UTRs. RNA, 12(6), 1074-1083. [More Information]
  • Sukocheva, O., Wadham, C., Holmes, A., Albanese, N., Verrier, E., Feng, F., Bernal, A., Derian, C., Ullrich, A., Vadas, M., Xia, P. (2006). Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. The Journal of Cell Biology, 173(2), 301-310. [More Information]
  • Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. [More Information]
  • Hissaria, P., Smith, W., Wormald, P., Taylor, J., Vadas, M., Gillis, D., Kette, F. (2006). Short course of systemic corticosteroids in sinonasal polyposis: A double-blind, randomized, placebo-controlled trial with evaluation of outcome measures. Journal of Allergy and Clinical Immunology, 118(1), 128-133. [More Information]
  • Sutherland, C., Moretti, P., Hewitt, N., Bagley, C., Vadas, M., Pitson, S. (2006). The Calmodulin-binding Site of Sphingosine Kinase and Its Role in Agonist-dependent Translocation of Sphingosine Kinase 1 to the Plasma Membrane. Journal of Biological Chemistry, 281(17), 11693-11701. [More Information]
  • Autelitano, D., Rajic, A., Smith, A., Berndt, M., Ilag, L., Vadas, M. (2006). The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities. Drug Discovery Today, 11(7/8), 306-314. [More Information]
  • Wang, L., Xing, X., Holmes, A., Wadham, C., Gamble, J., Vadas, M., Xia, P. (2005). Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells. Circulation Research, 97, 891-899. [More Information]
  • Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., Yu, S., Kremmidiotis, G., Gardner, A., Solomon, P., Vadas, M., Gamble, J., et al (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(-), 57-69. [More Information]
  • Coles, L., Lambrusco, L., Burrows, J., Hunter, J., Diamond, P., Bert, A., Vadas, M., Goodall, G. (2005). Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3β and repression of the human VEGF promoter. FEBS Letters, 579(24), 5372-5378. [More Information]
  • Pitson, S., Xia, P., Leclercq, T., Moretti, P., Zebol, J., Lynn, H., Wattenberg, B., Vadas, M. (2005). Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. The Journal of Experimental Medicine, 201(1), 49-54. [More Information]
  • Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. [More Information]
  • Coles, L., Bartley, M., Bert, A., Hunter, J., Polyak, S., Diamond, P., Vadas, M., Goodall, G. (2004). A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA: Potential role in mRNA stabilization. European Journal of Biochemistry, 271(3), 648-660.
  • Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., Kremmidiotis, G., Vadas, M., Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 101(33), 12212-12217.
  • Roberts, J., Moretti, P., Darrow, A., Derian, C., Vadas, M., Pitson, S. (2004). An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Analytical Biochemistry, 331(1), 122-129. [More Information]
  • Wadham, C., Albanese, N., Roberts, J., Wang, L., Bagley, C., Gamble, J., Rye, K., Barter, P., Vadas, M., Xia, P. (2004). High-Density Lipoproteins Neutralize C-Reactive Protein Proinflammatory Activity. Circulation, 109(17), 2116-2122. [More Information]
  • Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., Chatterjee, V., Vadas, M., Xia, P. (2004). PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase. Circulation Research, 94(11), 1515-1522.
  • Thomas, D., Vadas, M., Lopez, A. (2004). Regulation of haematopoiesis by growth factors - Emerging insights and therapies. Expert Opinion on Biological Therapy, 4(6), 869-879.
  • Li, X., Hahn, C., Parsons, M., Drew, J., Vadas, M., Gamble, J. (2004). Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood, 104(6), 1716-1724.
  • Stein, B., Gamble, J., Pitson, S., Vadas, M., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. Journal of Immunology, 171(11), 6097-6104.
  • Pitson, S., Moretti, P., Zebol, J., Lynn, H., Xia, P., Vadas, M., Wattenberg, B. (2003). Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. The EMBO Journal, 22(20), 5491-5500.
  • Imhof, B., Vadas, M. (2003). New therapeutic targets in vascular biology. Thrombosis and Haemostasis, 90(4), 557-559.
  • Sukocheva, O., Wang, L., Albanese, N., Pitson, S., Vadas, M., Xia, P. (2003). Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells. Molecular Endocrinology, 17(10), 2002-2012.
  • Wadham, C., Gamble, J., Vadas, M., Khew-Goodall, Y. (2003). The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates β-catenin. Molecular Biology of the Cell, 14(6), 2520-2529.
  • Gamble, J., Drew, J., Trezise, L., Underwood, A., Parsons, M., Parsons, M., Kasminkas, K., Rudge, J., Yancopoulos, G., Vadas, M. (2000). Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circulation Research, 87(7), 603-607.

2014

  • Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]

2013

  • Lichtenstein, I., Charleston, M., Caetano, T., Gamble, J., Vadas, M. (2013). Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies. BMC Bioinformatics, 14, 1-22. [More Information]
  • Coleman, P., Chang, G., Hutas Attila, G., Grimshaw, M., Vadas, M., Gamble, J. (2013). Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging, 5(12), 913-924.
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]

2011

  • Gamble, J., Vadas, M., McCaughan, G. (2011). Sinusoidal endothelium is essential for liver regeneration. Hepatology, 54(2), 731-733. [More Information]

2010

  • Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., Khew-Goodall, Y. (2010). A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration. Journal of Immunology, 185(5), 3057-3063. [More Information]
  • Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., Beck, K., Stocker, R., Vadas, M., Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. [More Information]

2009

  • Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 424-441. [More Information]
  • Gamble, J., Vadas, M. (2009). Insights into defibrotide as therapy for veno-occlusive disease. Hepatology, 49(2), 689-690. [More Information]
  • Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., Imhof, B., Vadas, M., Gamble, J. (2009). JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of beta 3 Integrins. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(8), 1200-1206. [More Information]
  • Sukocheva, O., Wang, L., Verrier, E., Vadas, M., Xia, P. (2009). Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology, 150(10), 4484-4492. [More Information]
  • Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., Pitson, S., Lopez, A., Coates, P., Proia, R., Vadas, M., Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. [More Information]
  • Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., Bonder, C. (2009). Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. The American Journal of Pathology: cellular and molecular biology of disease, 175(5), 2217-2225. [More Information]
  • Limaye, V., Vadas, M., Pitson, S., Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 411-423. [More Information]

2008

  • Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., Xia, P., Proia, R., Vadas, M., Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497.
  • Leclercq, T., Moretti, P., Vadas, M., Pitson, S. (2008). Eukaryotic Elongation Factor 1A Interacts with Sphingosine Kinase and Directly Enhances Its Catalytic Activity. Journal of Biological Chemistry, 283(15), 9606-9614. [More Information]
  • Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., Vadas, M., Khew-Goodall, Y., Goodall, G. (2008). The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601. [More Information]
  • Vadas, M., Xia, P., McCaughan, G., Gamble, J. (2008). The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction? BBA - Bioenergetics, 1781 (9), 442-447. [More Information]

2007

  • Soldi, R., Mandinova, A., Venkataraman, K., Hla, T., Vadas, M., Pitson, S., Duarte, M., Graziani, I., Kolev, V., Kacer, D., et al (2007). Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research: emphasizing molecular approaches to cell biology, 313(15), 3308-3318. [More Information]

2006

  • Bert, A., Grepin, R., Vadas, M., Goodall, G. (2006). Assessing IRES activity in the HIF-1α and other cellular 5′ UTRs. RNA, 12(6), 1074-1083. [More Information]
  • Sukocheva, O., Wadham, C., Holmes, A., Albanese, N., Verrier, E., Feng, F., Bernal, A., Derian, C., Ullrich, A., Vadas, M., Xia, P. (2006). Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. The Journal of Cell Biology, 173(2), 301-310. [More Information]
  • Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. [More Information]
  • Hissaria, P., Smith, W., Wormald, P., Taylor, J., Vadas, M., Gillis, D., Kette, F. (2006). Short course of systemic corticosteroids in sinonasal polyposis: A double-blind, randomized, placebo-controlled trial with evaluation of outcome measures. Journal of Allergy and Clinical Immunology, 118(1), 128-133. [More Information]
  • Sutherland, C., Moretti, P., Hewitt, N., Bagley, C., Vadas, M., Pitson, S. (2006). The Calmodulin-binding Site of Sphingosine Kinase and Its Role in Agonist-dependent Translocation of Sphingosine Kinase 1 to the Plasma Membrane. Journal of Biological Chemistry, 281(17), 11693-11701. [More Information]
  • Autelitano, D., Rajic, A., Smith, A., Berndt, M., Ilag, L., Vadas, M. (2006). The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities. Drug Discovery Today, 11(7/8), 306-314. [More Information]

2005

  • Wang, L., Xing, X., Holmes, A., Wadham, C., Gamble, J., Vadas, M., Xia, P. (2005). Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells. Circulation Research, 97, 891-899. [More Information]
  • Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., Yu, S., Kremmidiotis, G., Gardner, A., Solomon, P., Vadas, M., Gamble, J., et al (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(-), 57-69. [More Information]
  • Coles, L., Lambrusco, L., Burrows, J., Hunter, J., Diamond, P., Bert, A., Vadas, M., Goodall, G. (2005). Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3β and repression of the human VEGF promoter. FEBS Letters, 579(24), 5372-5378. [More Information]
  • Pitson, S., Xia, P., Leclercq, T., Moretti, P., Zebol, J., Lynn, H., Wattenberg, B., Vadas, M. (2005). Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. The Journal of Experimental Medicine, 201(1), 49-54. [More Information]
  • Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. [More Information]

2004

  • Coles, L., Bartley, M., Bert, A., Hunter, J., Polyak, S., Diamond, P., Vadas, M., Goodall, G. (2004). A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA: Potential role in mRNA stabilization. European Journal of Biochemistry, 271(3), 648-660.
  • Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., Kremmidiotis, G., Vadas, M., Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 101(33), 12212-12217.
  • Roberts, J., Moretti, P., Darrow, A., Derian, C., Vadas, M., Pitson, S. (2004). An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Analytical Biochemistry, 331(1), 122-129. [More Information]
  • Wadham, C., Albanese, N., Roberts, J., Wang, L., Bagley, C., Gamble, J., Rye, K., Barter, P., Vadas, M., Xia, P. (2004). High-Density Lipoproteins Neutralize C-Reactive Protein Proinflammatory Activity. Circulation, 109(17), 2116-2122. [More Information]
  • Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., Chatterjee, V., Vadas, M., Xia, P. (2004). PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase. Circulation Research, 94(11), 1515-1522.
  • Thomas, D., Vadas, M., Lopez, A. (2004). Regulation of haematopoiesis by growth factors - Emerging insights and therapies. Expert Opinion on Biological Therapy, 4(6), 869-879.
  • Li, X., Hahn, C., Parsons, M., Drew, J., Vadas, M., Gamble, J. (2004). Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood, 104(6), 1716-1724.

2003

  • Stein, B., Gamble, J., Pitson, S., Vadas, M., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. Journal of Immunology, 171(11), 6097-6104.
  • Pitson, S., Moretti, P., Zebol, J., Lynn, H., Xia, P., Vadas, M., Wattenberg, B. (2003). Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. The EMBO Journal, 22(20), 5491-5500.
  • Imhof, B., Vadas, M. (2003). New therapeutic targets in vascular biology. Thrombosis and Haemostasis, 90(4), 557-559.
  • Sukocheva, O., Wang, L., Albanese, N., Pitson, S., Vadas, M., Xia, P. (2003). Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells. Molecular Endocrinology, 17(10), 2002-2012.
  • Wadham, C., Gamble, J., Vadas, M., Khew-Goodall, Y. (2003). The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates β-catenin. Molecular Biology of the Cell, 14(6), 2520-2529.

2000

  • Gamble, J., Drew, J., Trezise, L., Underwood, A., Parsons, M., Parsons, M., Kasminkas, K., Rudge, J., Yancopoulos, G., Vadas, M. (2000). Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circulation Research, 87(7), 603-607.

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