Dr Matthew Naylor

Senior Lecturer
Physiology, School of Medical Sciences

Telephone +61 2 9351 4267

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Research interests

Research in the Developmental & Cancer Biology Lab focuses on understanding the mechanisms that control normal development and cell function and then how these processes are perturbed in human disease such as cancer.

Specifically, research in the lab has focused on transcriptional and cell-matrix regulators of cell fate (eg. whether or not a cell undergoes proliferation or differentiation) in breast and prostate development and cancer. Using transcript profiling and subsequent mouse and cell based models, we have identified several novel regulators of normal breast and prostate development and shown that perturbing the function of these genes influences cancer progression. We are now exploring the functional mechanism of these genes, expanding our studies to human patient cohorts and investigating the role of newly identified targets. As the genes and developmental pathways we work on control cell fate decisions in multiple systems we will examine the function of these genes in major human diseases such as breast & prostate cancer, bone metastasis, cardiovascular (artherosclerosis), muscle and heart disease.

Selected grants

2014

  • CBFβ in breast cancer; Naylor M, Ormandy C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • A high-throughput, bright-field and fluorescence digital slide scanning platform and service that is both research and teaching-focused and available University-wide.; King N, Graeber M, Naylor M, Slapeta J, Quinnell R, Charles (nee Slaviero) K, Owens T, Bourne R, Braet F, Hambly B, Overall R, Stone J, Twigg S, Hardikar A, Halliday G, Richardson D, Byrne M, Keay K, Marsh D, Howell V, Pollock C, Chen X; DVC Research/Equipment Grant.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Linking breast development to bone metastasis: Role for the osteogenic transcription factor Runx2 during breast carcinogenesis; Naylor M, Carroll J, Simpson P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Role of beta1 integrin in prostate development and carinogenesis; Naylor M; Cancer Council New South Wales/Research Project Grants.
  • Personalising breast cancer management by discovering the transcriptional basis for tumour phenotype; Naylor M; Cancer Council New South Wales/Program Grant.
  • Role of b1 integrin in prostate cancer; Naylor M; Prostate Cancer Foundation of Australia/Young Investigator Grants.
  • Investigation of cell fate regulation during mammary gland development, carcinogenesis and metastasis; Naylor M; National Breast Cancer Foundation/Early Career Fellowship.
  • The role of integrin signalling in breast and prostate cancer; Naylor M; National Health and Medical Research Council (NHMRC)/Career Development Awards.

Selected publications

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Book Chapters

  • Naylor, M., Streuli, C. (2006). Integrin Regulation of Mammary Gland Development. In Erik H.J. Danen (Eds.), Integrins and Development, (pp. 176-185). Landes Bioscience.

Journals

  • Anderson, L., Owens, T., Naylor, M. (2014). Integrins in development and cancer. Biophysical Reviews, 6, 191-202. [More Information]
  • Anderson, L., Owens, T., Naylor, M. (2014). Structural and mechanical functions of integrins. Biophysical Reviews, 6, 203-213. [More Information]
  • Owens, T., Naylor, M. (2013). Breast cancer stem cells. Frontiers in Physiology, 4, 1-10. [More Information]
  • Moran-Jones, K., Ledger, A., Naylor, M. (2012). B1 integrin deletion enhances progression of prostate cancer in the TRAMP mouse model. Scientific Reports, 2(Article number 526), 1-7. [More Information]
  • Kalyuga, M., Gallego-Ortega, D., Lee, H., Roden, D., Cowley, M., Caldon, C., Stone, A., Allerdice, S., Valdes-Mora, F., Launchbury, R., Naylor, M., et al (2012). ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer. PLoS Biology, 10(12), 1-17. [More Information]
  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology, 24(7), 1380-1392. [More Information]
  • Rogers, R., Van Seuningen, I., Gould, J., Hertzog, P., Naylor, M., Pritchard, M. (2010). Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5. PLoS One, 5(10), e13150. [More Information]
  • Akhtar, N., Marlow, R., Lambert, E., Schatzmann, F., Lowe, E., Cheung, J., Katz, E., Li, W., Wu, C., Dedhar, S., et al (2009). Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development (Cambridge) (Print), 136(6), 1019-1027. [More Information]
  • Oakes, S., Rogers, R., Naylor, M., Ormandy, C. (2008). Prolactin regulation of mammary gland development. Journal of Mammary Gland Biology and Neoplasia, 13(1), 13-28. [More Information]
  • Oakes, S., Naylor, M., Asselin-Labat, M., Blazek, K., Gardiner-Garden, M., Hilton, H., Kazlauskas, M., Pritchard, M., Chodosh, L., Pfeffer, P., et al (2008). The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes and Development, 22(5), 581-586. [More Information]
  • Naylor, M., Ormandy, C. (2007). Gata-3 and mammary cell fate. Breast Cancer Research, 9(2), 302. [More Information]
  • Harris, J., Stanford, P., Sutherland, K., Oakes, S., Naylor, M., Robertson, F., Blazek, K., Kazlauskas, M., Hilton, H., Wittlin, S., et al (2006). Socs2 and elf5 mediate prolactin-induced mammary gland development. Molecular Endocrinology, 20(5), 1177-1187. [More Information]
  • Naylor, M., Li, N., Cheung, J., Lowe, E., Lambert, E., Marlow, R., Wang, P., Schatzmann, F., Wintermantel, T., Schuetz, G., et al (2005). Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. The Journal of Cell Biology, 171(4), 717-28. [More Information]
  • Li, N., Naylor, M., Schatzmann, F., Wintermantel, T., Schuetz, G., Mueller, U., Streuli, C., Hynes, N. (2005). Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. The EMBO Journal, 24(11), 1942-53. [More Information]
  • Shou, J., Chehab, R., Tkalcevic, J., Naylor, M., Harris, J., Wilson, T., Tsao, S., Tellis, I., Zavarsek, S., Xu, D., et al (2005). Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. The EMBO Journal, 24(3), 635-44. [More Information]
  • Naylor, M., Oakes, S., Gardiner-Garden, M., Harris, J., Blazek, K., Ho, T., Li, F., Wynick, D., Walker, A., Ormandy, C. (2005). Transcriptional changes underlying the secretory activation phase of mammary gland development. Molecular Endocrinology, 19(7), 1868-1883. [More Information]

2014

  • Anderson, L., Owens, T., Naylor, M. (2014). Integrins in development and cancer. Biophysical Reviews, 6, 191-202. [More Information]
  • Anderson, L., Owens, T., Naylor, M. (2014). Structural and mechanical functions of integrins. Biophysical Reviews, 6, 203-213. [More Information]

2013

  • Owens, T., Naylor, M. (2013). Breast cancer stem cells. Frontiers in Physiology, 4, 1-10. [More Information]

2012

  • Moran-Jones, K., Ledger, A., Naylor, M. (2012). B1 integrin deletion enhances progression of prostate cancer in the TRAMP mouse model. Scientific Reports, 2(Article number 526), 1-7. [More Information]
  • Kalyuga, M., Gallego-Ortega, D., Lee, H., Roden, D., Cowley, M., Caldon, C., Stone, A., Allerdice, S., Valdes-Mora, F., Launchbury, R., Naylor, M., et al (2012). ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer. PLoS Biology, 10(12), 1-17. [More Information]

2010

  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology, 24(7), 1380-1392. [More Information]
  • Rogers, R., Van Seuningen, I., Gould, J., Hertzog, P., Naylor, M., Pritchard, M. (2010). Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5. PLoS One, 5(10), e13150. [More Information]

2009

  • Akhtar, N., Marlow, R., Lambert, E., Schatzmann, F., Lowe, E., Cheung, J., Katz, E., Li, W., Wu, C., Dedhar, S., et al (2009). Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development (Cambridge) (Print), 136(6), 1019-1027. [More Information]

2008

  • Oakes, S., Rogers, R., Naylor, M., Ormandy, C. (2008). Prolactin regulation of mammary gland development. Journal of Mammary Gland Biology and Neoplasia, 13(1), 13-28. [More Information]
  • Oakes, S., Naylor, M., Asselin-Labat, M., Blazek, K., Gardiner-Garden, M., Hilton, H., Kazlauskas, M., Pritchard, M., Chodosh, L., Pfeffer, P., et al (2008). The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes and Development, 22(5), 581-586. [More Information]

2007

  • Naylor, M., Ormandy, C. (2007). Gata-3 and mammary cell fate. Breast Cancer Research, 9(2), 302. [More Information]

2006

  • Naylor, M., Streuli, C. (2006). Integrin Regulation of Mammary Gland Development. In Erik H.J. Danen (Eds.), Integrins and Development, (pp. 176-185). Landes Bioscience.
  • Harris, J., Stanford, P., Sutherland, K., Oakes, S., Naylor, M., Robertson, F., Blazek, K., Kazlauskas, M., Hilton, H., Wittlin, S., et al (2006). Socs2 and elf5 mediate prolactin-induced mammary gland development. Molecular Endocrinology, 20(5), 1177-1187. [More Information]

2005

  • Naylor, M., Li, N., Cheung, J., Lowe, E., Lambert, E., Marlow, R., Wang, P., Schatzmann, F., Wintermantel, T., Schuetz, G., et al (2005). Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. The Journal of Cell Biology, 171(4), 717-28. [More Information]
  • Li, N., Naylor, M., Schatzmann, F., Wintermantel, T., Schuetz, G., Mueller, U., Streuli, C., Hynes, N. (2005). Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. The EMBO Journal, 24(11), 1942-53. [More Information]
  • Shou, J., Chehab, R., Tkalcevic, J., Naylor, M., Harris, J., Wilson, T., Tsao, S., Tellis, I., Zavarsek, S., Xu, D., et al (2005). Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. The EMBO Journal, 24(3), 635-44. [More Information]
  • Naylor, M., Oakes, S., Gardiner-Garden, M., Harris, J., Blazek, K., Ho, T., Li, F., Wynick, D., Walker, A., Ormandy, C. (2005). Transcriptional changes underlying the secretory activation phase of mammary gland development. Molecular Endocrinology, 19(7), 1868-1883. [More Information]

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