Dr Matthew O'Sullivan

MBBS MMed (ClinEpi) PhD DTM&H, FRACP FRCPA
Clinical Senior Lecturer
Medicine, Westmead Clinical School

Telephone +61 2 9845 6255

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Biographical details

Dr O'Sullivan is an infectious diseases specialist and clinical microbiologist with a research interest in genotyping of pathogens responsible for hospital-aqcuired infections, particularly MRSA. He graduated in medicine from the University of Queensland in 1996 and has a Master of Medicine (Clinical Epidemiology) from the University of Sydney and a Diploma of Tropical Medicine and Hygiene from the London School of Hygiene and Tropical Medicine. He was awarded his PhD from the University of Sydney in 2013 for a thesis entitled "A prospective methicillin-resistant Staphylococcus aureus typing system for infection control: Design and effectiveness".

Research interests

Molecular epidemiology of methicillin-resistant Staphylococcus aureus and the application of microbial typing to hospital infection control.

Selected grants

2014

  • The true burden of nosocomial staphylococcal disease: Genomic markers of transmission of methicillin-sensitive and - resistant Staphylococcus aureus; O'Sullivan M, Gilbert G, Sintchenko V, Holmes N, van Hal S; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Microevolution and transmission of MRSA in a hospital setting; Gilbert G, Sintchenko V, O'Sullivan M, Iredell J; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Strengthening frontline clinicians' infection control: A multi-method study to reduce MRSA infection and transmission; Iedema R, Gilbert G, Hooker C, O'Sullivan M, Jorm C; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • O'Sullivan, M. (2010). Microbial Genotyping Systems for Infection Control. In Vitali Sintchenko (Eds.), Infectious Disease Informatics, (pp. 345-358). New York: Springer.

Journals

  • Zhou, F., Wang, Q., Sintchenko, V., Gilbert, G., O'Sullivan, M., Iredell, J., Dwyer, D. (2014). Use of the 5' Untranslated Region and VP1 Region to Examine the Molecular Diversity in Enterovirus B Species. Journal of Medical Microbiology, 63(PT10), 1339-1355. [More Information]
  • Pinto, A., Seth, R., Zhou, F., Tallon, J., Dempsey, K., Tracy, M., Gilbert, G., O'Sullivan, M. (2013). Emergence and control of an outbreak of infections due to Panton-Valentine leukocidin positive, ST22 methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Clinical Microbiology and Infection, 19(7), 620-627. [More Information]
  • Hunter, M., Clezy, K., Hajkowicz, K., Hoy, J., Hume, S., O'Sullivan, M., Runnegar, N., Sasadeusz, J., Post, J. (2013). Late diagnosis of human immunodeficiency virus infection in patients with viral hepatitis. Internal Medicine Journal, 43(6), 732-734. [More Information]
  • Xiao, M., Wang, H., Zhao, Y., Mao, L., Brown, M., Yu, Y., O'Sullivan, M., Kong, F., Xu, Y. (2013). National Surveillance of Methicillin-Resistant Staphylococcus aureus in China Highlights a Still-Evolving Epidemiology with 15 Novel Emerging Multilocus Sequence Types. Journal of Clinical Microbiology, 51(11), 3638-3644. [More Information]
  • O'Sullivan, M., Sintchenko, V., Gilbert, G. (2013). Quantitative Estimation of the Stability of Methicillin-Resistant Staphylococcus aureus Strain-Typing Systems by Use of Kaplan-Meier Survival Analysis. Journal of Clinical Microbiology, 51(1), 112-116. [More Information]
  • O'Sullivan, M., Sintchenko, V., Gilbert, G. (2013). Software for selecting the most informative sets of genomic loci for multi-target microbial typing. BMC Bioinformatics, 14(148), 1-8. [More Information]
  • Holmes, N., Turnidge, J., Munckhof, W., Robinson, J., Korman, T., O'Sullivan, M., Anderson, T., Roberts, S., Warren, S., Gao, W., et al (2013). Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia. Antimicrobial Agents and Chemotherapy, 57(4), 1654-1663. [More Information]
  • Holmes, N., Turnidge, J., Munckhof, W., Robinson, J., Korman, T., O'Sullivan, M., Anderson, T., Roberts, S., Warren, S., Gao, W., et al (2013). Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia. Clinical Microbiology and Infection, 19(12), 1163-1168. [More Information]
  • O'Sullivan, M., Zhou, F., Sintchenko, V., Gilbert, G. (2012). Prospective Genotyping of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus by Use of a Novel, Highly Discriminatory Binary Typing System. Journal of Clinical Microbiology, 50(11), 3513-3519. [More Information]
  • Holmes, N., Turnidge, J., Munckhof, W., Robinson, J., Korman, T., O'Sullivan, M., Anderson, T., Roberts, S., Gao, W., Christiansen, K., et al (2011). Antibiotic Choice May Not Explain Poorer Outcomes in Patients With Staphylococcus aureus Bacteremia and High Vancomycin Minimum Inhibitory Concentrations. The Journal of Infectious Diseases, 204(3), 340-347. [More Information]
  • Kok, J., O'Sullivan, M., Gilbert, G. (2011). Feedback to clinicians on preventable factors can reduce hospital onset Staphylococcus aureus bacteraemia rates. Journal of Hospital Infection, 79(2), 108-114. [More Information]
  • O'Sullivan, M., Zhou, F., Sintchenko, V., Kong, F., Gilbert, G. (2011). Multiplex PCR and Reverse Line Blot Hybridization Assay (mPCR/RLB). Journal of Visualized Experiments, 6(54), e2781-1-e2781-5. [More Information]
  • O'Sullivan, M., Kong, F., Sintchenko, V., Gilbert, G. (2010). Rapid Identification of MRSA Transmission in Hospitals using Phage-Derived ORF Typing enhanced by Multiplex PCR and Reverse Line Blot Assay. Journal of Clinical Microbiology, 48(8), 2741-2748. [More Information]
  • Liu, Y., Kong, F., Xiao, M., Wang, Q., O'Sullivan, M., Sintchenko, V., Lin, M., Gilbert, G. (2010). Unexpected Diversity of Staphylococcal Cassette Chromosome mec Type IV in Methicillin-Resistant Staphylococcus aureus Strains. Journal of Clinical Microbiology, 48(10), 3628-3634. [More Information]
  • Thomas, L., van Hal, S., O'Sullivan, M., Kyme, P., Iredell, J. (2008). Failure of the BD GeneOhm(R) StaphS/R assay for Identification of Australian Methicillin-Resistant Staphylococcus aureus strains: duplex assays remain the 'gold standard' in settings of unknown SCCmec epidemiology. Journal of Clinical Microbiology, 46(12), 4116-4117. [More Information]
  • Fernandes, C., O'Sullivan, M., Cai, Y., Kong, F., Zeng, X., Gilbert, G., Kotsiou, G. (2007). An agar dilution method for the detection of inducible clindamycin resistance in Staphylococcus spp. Journal of Clinical Microbiology, 45(12), 4018-4020. [More Information]
  • Ralph, A., O'Sullivan, M., Sangster, N., Walker, J. (2006). Abdominal pain and eosinophilia in suburban goat keepers - trichostrongylosis. Medical Journal of Australia, 184(9), 467-469. [More Information]
  • O'Sullivan, M., Cai, Y., Kong, F., Zeng, X., Gilbert, G. (2006). Influence of disk separation distance on accuracy of the disk approximation test for detection of inducible clindamycin resistance in Staphylococcus spp. Journal of Clinical Microbiology, 44(11), 4072-4076. [More Information]
  • Coen, M., O'Sullivan, M., Bubb, W., Kuchel, P., Sorrell, T. (2005). Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis. Clinical Infectious Diseases, 41(11), 1582-1590. [More Information]

2014

  • Zhou, F., Wang, Q., Sintchenko, V., Gilbert, G., O'Sullivan, M., Iredell, J., Dwyer, D. (2014). Use of the 5' Untranslated Region and VP1 Region to Examine the Molecular Diversity in Enterovirus B Species. Journal of Medical Microbiology, 63(PT10), 1339-1355. [More Information]

2013

  • Pinto, A., Seth, R., Zhou, F., Tallon, J., Dempsey, K., Tracy, M., Gilbert, G., O'Sullivan, M. (2013). Emergence and control of an outbreak of infections due to Panton-Valentine leukocidin positive, ST22 methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Clinical Microbiology and Infection, 19(7), 620-627. [More Information]
  • Hunter, M., Clezy, K., Hajkowicz, K., Hoy, J., Hume, S., O'Sullivan, M., Runnegar, N., Sasadeusz, J., Post, J. (2013). Late diagnosis of human immunodeficiency virus infection in patients with viral hepatitis. Internal Medicine Journal, 43(6), 732-734. [More Information]
  • Xiao, M., Wang, H., Zhao, Y., Mao, L., Brown, M., Yu, Y., O'Sullivan, M., Kong, F., Xu, Y. (2013). National Surveillance of Methicillin-Resistant Staphylococcus aureus in China Highlights a Still-Evolving Epidemiology with 15 Novel Emerging Multilocus Sequence Types. Journal of Clinical Microbiology, 51(11), 3638-3644. [More Information]
  • O'Sullivan, M., Sintchenko, V., Gilbert, G. (2013). Quantitative Estimation of the Stability of Methicillin-Resistant Staphylococcus aureus Strain-Typing Systems by Use of Kaplan-Meier Survival Analysis. Journal of Clinical Microbiology, 51(1), 112-116. [More Information]
  • O'Sullivan, M., Sintchenko, V., Gilbert, G. (2013). Software for selecting the most informative sets of genomic loci for multi-target microbial typing. BMC Bioinformatics, 14(148), 1-8. [More Information]
  • Holmes, N., Turnidge, J., Munckhof, W., Robinson, J., Korman, T., O'Sullivan, M., Anderson, T., Roberts, S., Warren, S., Gao, W., et al (2013). Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia. Antimicrobial Agents and Chemotherapy, 57(4), 1654-1663. [More Information]
  • Holmes, N., Turnidge, J., Munckhof, W., Robinson, J., Korman, T., O'Sullivan, M., Anderson, T., Roberts, S., Warren, S., Gao, W., et al (2013). Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia. Clinical Microbiology and Infection, 19(12), 1163-1168. [More Information]

2012

  • O'Sullivan, M., Zhou, F., Sintchenko, V., Gilbert, G. (2012). Prospective Genotyping of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus by Use of a Novel, Highly Discriminatory Binary Typing System. Journal of Clinical Microbiology, 50(11), 3513-3519. [More Information]

2011

  • Holmes, N., Turnidge, J., Munckhof, W., Robinson, J., Korman, T., O'Sullivan, M., Anderson, T., Roberts, S., Gao, W., Christiansen, K., et al (2011). Antibiotic Choice May Not Explain Poorer Outcomes in Patients With Staphylococcus aureus Bacteremia and High Vancomycin Minimum Inhibitory Concentrations. The Journal of Infectious Diseases, 204(3), 340-347. [More Information]
  • Kok, J., O'Sullivan, M., Gilbert, G. (2011). Feedback to clinicians on preventable factors can reduce hospital onset Staphylococcus aureus bacteraemia rates. Journal of Hospital Infection, 79(2), 108-114. [More Information]
  • O'Sullivan, M., Zhou, F., Sintchenko, V., Kong, F., Gilbert, G. (2011). Multiplex PCR and Reverse Line Blot Hybridization Assay (mPCR/RLB). Journal of Visualized Experiments, 6(54), e2781-1-e2781-5. [More Information]

2010

  • O'Sullivan, M. (2010). Microbial Genotyping Systems for Infection Control. In Vitali Sintchenko (Eds.), Infectious Disease Informatics, (pp. 345-358). New York: Springer.
  • O'Sullivan, M., Kong, F., Sintchenko, V., Gilbert, G. (2010). Rapid Identification of MRSA Transmission in Hospitals using Phage-Derived ORF Typing enhanced by Multiplex PCR and Reverse Line Blot Assay. Journal of Clinical Microbiology, 48(8), 2741-2748. [More Information]
  • Liu, Y., Kong, F., Xiao, M., Wang, Q., O'Sullivan, M., Sintchenko, V., Lin, M., Gilbert, G. (2010). Unexpected Diversity of Staphylococcal Cassette Chromosome mec Type IV in Methicillin-Resistant Staphylococcus aureus Strains. Journal of Clinical Microbiology, 48(10), 3628-3634. [More Information]

2008

  • Thomas, L., van Hal, S., O'Sullivan, M., Kyme, P., Iredell, J. (2008). Failure of the BD GeneOhm(R) StaphS/R assay for Identification of Australian Methicillin-Resistant Staphylococcus aureus strains: duplex assays remain the 'gold standard' in settings of unknown SCCmec epidemiology. Journal of Clinical Microbiology, 46(12), 4116-4117. [More Information]

2007

  • Fernandes, C., O'Sullivan, M., Cai, Y., Kong, F., Zeng, X., Gilbert, G., Kotsiou, G. (2007). An agar dilution method for the detection of inducible clindamycin resistance in Staphylococcus spp. Journal of Clinical Microbiology, 45(12), 4018-4020. [More Information]

2006

  • Ralph, A., O'Sullivan, M., Sangster, N., Walker, J. (2006). Abdominal pain and eosinophilia in suburban goat keepers - trichostrongylosis. Medical Journal of Australia, 184(9), 467-469. [More Information]
  • O'Sullivan, M., Cai, Y., Kong, F., Zeng, X., Gilbert, G. (2006). Influence of disk separation distance on accuracy of the disk approximation test for detection of inducible clindamycin resistance in Staphylococcus spp. Journal of Clinical Microbiology, 44(11), 4072-4076. [More Information]

2005

  • Coen, M., O'Sullivan, M., Bubb, W., Kuchel, P., Sorrell, T. (2005). Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis. Clinical Infectious Diseases, 41(11), 1582-1590. [More Information]

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