Dr Matthew O'Sullivan
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Dr Matthew O'Sullivan

MBBS MMed (ClinEpi) PhD DTM&H, FRACP FRCPA
Clinical Associate Professor
Medicine, Westmead Clinical School
Dr Matthew O'Sullivan

Dr O'Sullivan is an Infectious Diseases Physician and Medical Microbiologist. He has a clinical interest in staphylococcal infection, tropical medicine, HIV, infections in immunocompromised hosts and diagnosis, management and clinical biocontainment for High Consequence Infectious Diseases such as Ebola and COVID-19. His research interest is in genotyped-based surveillance of pathogens responsible for hospital-aqcuired infections. He graduated in medicine from the University of Queensland in 1996 and has a Master of Medicine (Clinical Epidemiology) from the University of Sydney and a Diploma of Tropical Medicine and Hygiene from the London School of Hygiene and Tropical Medicine. He was awarded his PhD from the University of Sydney in 2013 for a thesis entitled "A prospective methicillin-resistant Staphylococcus aureus typing system for infection control: Design and effectiveness".

High Consequence Infectious Diseases (HCIDs): Diagnosis, management and clinical biocontainment.

Molecular epidemiology of methicillin-resistant Staphylococcus aureus and the application of microbial typing to hospital infection control.

Infection and Immunological Conditions

Publications

Book Chapters

  • Shaban, R., O'Sullivan, M., Li, C., Viengkham, C. (2023). High consequence infectious diseases and biocontainment for health protection. In Ramon Z. Shaban, Brett G. Mitchell, Deborough Macbeth, Philip Russo (Eds.), Healthcare-associated infections in Australia: Principles and practices of infection prevention and control. 1st ed. Australia: Elsevier.
  • O'Sullivan, M. (2010). Microbial Genotyping Systems for Infection Control. In Vitali Sintchenko (Eds.), Infectious Disease Informatics, (pp. 345-358). New York: Springer. [More Information]

Journals

  • Asquith, W., Sriramoju, S., Sutor, A., O'Sullivan, M., HUESTON, L., Dwyer, D., Kok, J., Ko, D., Fennel, M., Rockett, R., et al (2024). Characterizing the acute antibody response of monkeypox and MVA-BN vaccine following an Australian outbreak. Journal of Medical Virology, 96(1), e29407. [More Information]
  • Cheung, N., Gilroy, N., Hor, A., Jose, S., Kairaitis, K., Nayyar, V., O'Sullivan, M., Wheatley, J., Chipps, D. (2023). Diabetes and hyperglycaemia among hospitalised patients with COVID-19 in Western Sydney: a retrospective cohort study. Internal Medicine Journal, 53(2), 194-201. [More Information]
  • Dotel, R., Gilbert, G., Hutabarat, S., Davis, J., O'Sullivan, M. (2023). Effectiveness of adjunctive rifampicin for treatment of Staphylococcus aureus bacteraemia: a systematic review and meta-analysis of randomized controlled trials. Journal of Antimicrobial Chemotherapy, 78(10), 2419-2427. [More Information]

2024

  • Asquith, W., Sriramoju, S., Sutor, A., O'Sullivan, M., HUESTON, L., Dwyer, D., Kok, J., Ko, D., Fennel, M., Rockett, R., et al (2024). Characterizing the acute antibody response of monkeypox and MVA-BN vaccine following an Australian outbreak. Journal of Medical Virology, 96(1), e29407. [More Information]

2023

  • Cheung, N., Gilroy, N., Hor, A., Jose, S., Kairaitis, K., Nayyar, V., O'Sullivan, M., Wheatley, J., Chipps, D. (2023). Diabetes and hyperglycaemia among hospitalised patients with COVID-19 in Western Sydney: a retrospective cohort study. Internal Medicine Journal, 53(2), 194-201. [More Information]
  • Dotel, R., Gilbert, G., Hutabarat, S., Davis, J., O'Sullivan, M. (2023). Effectiveness of adjunctive rifampicin for treatment of Staphylococcus aureus bacteraemia: a systematic review and meta-analysis of randomized controlled trials. Journal of Antimicrobial Chemotherapy, 78(10), 2419-2427. [More Information]
  • Shaban, R., O'Sullivan, M., Li, C., Viengkham, C. (2023). High consequence infectious diseases and biocontainment for health protection. In Ramon Z. Shaban, Brett G. Mitchell, Deborough Macbeth, Philip Russo (Eds.), Healthcare-associated infections in Australia: Principles and practices of infection prevention and control. 1st ed. Australia: Elsevier.

2022

  • Denholm, J., Venkatesh, B., Davis, J., Bowen, A., Hammond, N., Jha, V., McPhee, G., McQuilten, Z., O'Sullivan, M., Paterson, D., Jones, M., Totterdell, J., Snelling, T., et al (2022). ASCOT ADAPT study of COVID-19 therapeutics in hospitalised patients: an international multicentre adaptive platform trial. Trials, 23(1). [More Information]
  • Campbell, A., Dotel, R., Braddick, M., Britton, P., Eisen, D., Francis, J., Lynar, S., McMullan, B., Meagher, N., Nelson, J., O'Sullivan, M., et al (2022). Clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation (CASSETTE) - An open-labelled pilot randomized controlled trial. Journal of Antimicrobial Chemotherapy-AMR, 4(1). [More Information]
  • Pham, D., Howard-Jones, A., Hueston, L., Jeoffreys, N., Doggett, S., Rockett, R., Eden, J., Sintchenko, V., Chen, S., O'Sullivan, M., Dwyer, D., et al (2022). Emergence of Japanese encephalitis in Australia: a diagnostic perspective. Pathology, 54(6), 669-677. [More Information]

2021

  • Axfors, C., Janiaud, P., Schmitt, A., van’t Hooft, J., Smith, E., Haber, N., Abayomi, A., Abduljalil, M., Abdulrahman, A., Acosta-Ampudia, Y., O'Sullivan, M., Snelling, T., et al (2021). Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials. BMC Infectious Diseases, 21(1), 1170. [More Information]
  • Basile, K., McPhie, K., Carter, I., Alderson, S., Rahman, H., Donovan, L., Kumar, S., Tran, T., Ko, D., Sivaruban, T., O'Sullivan, M., Sintchenko, V., Chen, S., Dwyer, D., Kok, J., et al (2021). Cell-based Culture Informs Infectivity and Safe De-Isolation Assessments in Patients with Coronavirus Disease 2019. Clinical Infectious Diseases, 73(9), E2952-E2959. [More Information]
  • Sintchenko, V., Timms, V., Sim, E., Rockett, R., Bachmann, N., O'Sullivan, M., Marais, B. (2021). Microbial Genomics as a Catalyst for Targeted Antivirulence Therapeutics. Frontiers in Medicine, 8, 641260. [More Information]

2020

  • Beukers, A., Newton, P., Hudson, B., Ross, K., Gottlieb, T., O'Sullivan, M., Daley, D., Pang, S., Coombs, G., van Hal, S. (2020). A multicentre outbreak of ST45 MRSA containing deletions in the spa gene in New South Wales, Australia. Journal of Antimicrobial Chemotherapy, 75(5), 1112-1116. [More Information]
  • Robosa, R., Sandaradura, I., Dwyer, D., O'Sullivan, M. (2020). Clinical evaluation of SARS-CoV-2 point-of-care antibody tests. Pathology, 52(7), 783-789. [More Information]
  • Tong, S., Lye, D., Yahav, D., Sud, A., Robinson, J., Nelson, J., Archuleta, S., Roberts, M., Cass, A., Paterson, D., Dotel, R., McKew, G., Gray, T., O'Sullivan, M., Van Hal, S., et al (2020). Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial. JAMA, 323(6), 527-537. [More Information]

2019

  • Dotel, R., Tong, S., Bowen, A., Nelson, J., O'Sullivan, M., Campbell, A., McMullan, B., Britton, P., Francis, J., Eisen, D., et al (2019). CASSETTE-clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: study protocol for a randomised controlled trial. Trials, 20(1), 1-13. [More Information]
  • Steinig, E., Duchene, S., Robinson, D., Monecke, S., Yokoyama, M., Laabei, M., Slickers, P., Andersson, P., Williamson, D., Kearns, A., O'Sullivan, M., et al (2019). Evolution and global transmission of a multidrug-resistant, community-associated methicillin-resistant staphylococcus aureus lineage from the Indian subcontinent. Scandinavian Journal of Work Environment and Health, 10(6), e01105-19. [More Information]
  • Dotel, R., O'Sullivan, M., Davis, J., Newton, P., Gilbert, G. (2019). Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolates in New South Wales, Australia, 2012-2017. Infection, Disease & Health, 24(3), 134-140. [More Information]

2018

  • Robson, C., O'Sullivan, M., Sivagnanam, S. (2018). Salmonella enterica Serovar Typhi: An Unusual Cause of Infective Endocarditis. Tropical Medicine and Infectious Disease, 3(1), 1-5. [More Information]

2017

  • Hor, S., Hooker, L., Iedema, R., Wyer, M., Gilbert, G., Jorm, C., O'Sullivan, M. (2017). Beyond hand hygiene: a qualitative study of the everyday work of preventing cross-contamination on hospital wards. BMJ Quality and Safety, 26(7), 552-558. [More Information]
  • Trad, M., Naughton, W., Yeung, A., Mazlin, L., O'Sullivan, M., Gilroy, N., Fisher, D., Stuart, R. (2017). Ebola virus disease: An update on current prevention and management strategies. Journal Of Clinical Virology, 86, 5-13. [More Information]
  • Brown, J., Willcox, S., Franklin, N., Hazelton, B., Howard, P., Reinten, T., Sheppeard, V., O'Sullivan, M. (2017). Shigella species epidemiology and antimicrobial susceptibility: the implications of emerging azithromycin resistance for guiding treatment, guidelines and breakpoints. Journal of Antimicrobial Chemotherapy, 72(11), 3181-3186. [More Information]

2016

  • Tong, S., Nelson, J., Paterson, D., Fowler Jr, V., Howden, B., Cheng, A., Chatfield, M., Lipman, J., Van Hal, S., O'Sullivan, M., et al (2016). CAMERA2 - combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial. Trials, 17(1), 1-15. [More Information]
  • Davis, J., Sud, A., O'Sullivan, M., Robinson, J., Ferguson, P., Foo, H., Van Hal, S., Ralph, A., Howden, B., Binks, P., Kirby, A., et al (2016). Combination of Vancomycin and B-Lactam Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: A Pilot Multicenter Randomized Controlled Trial. Clinical Infectious Diseases, 62(2), 173-180. [More Information]
  • Pollett, S., Banner, P., O'Sullivan, M., Ralph, A. (2016). Epidemiology, Diagnosis and Management of Extra-Pulmonary Tuberculosis in a Low-Prevalence Country: A Four Year Retrospective Study in an Australian Tertiary Infectious Diseases Unit. PloS One, 11(3), 1-15. [More Information]

2015

  • Zhang, H., Xiao, M., Kong, F., O'Sullivan, M., Mao, L., Zhao, H., Zhao, Y., Wang, H., Xu, Y. (2015). A multicentre study of meticillin-resistant Staphylococcus aureus in acute bacterial skin and skin-structure infections in China: Susceptibility to ceftaroline and molecular epidemiology. International Journal of Antimicrobial Agents, 45(4), 347-350. [More Information]
  • Iedema, R., Hor, S., Wyer, M., Gilbert, G., Jorm, C., Hooker, L., O'Sullivan, M. (2015). An innovative approach to strengthening health professionals' infection control and limiting hospital-acquired infection: video-reflexive ethnography. BMJ Innovations, 1(4), 157-162. [More Information]
  • Tran, M., Iredell, J., Packham, D., O'Sullivan, M., Hudson, B. (2015). Delusional infestation: an Australian multicentre study of 23 consecutive cases. Internal Medicine Journal, 45(4), 454-456. [More Information]

2014

  • Holmes, N., Turnidge, J., Munckhof, W., Robinson, O., Korman, T., O'Sullivan, M., Anderson, T., Roberts, S., Warren, S., Coombs, G., et al (2014). Genetic and molecular predictors of high vancomycin MIC in Staphylococcus aureus bacteremia isolates. Journal of Clinical Microbiology, 52(9), 3384-3393. [More Information]
  • Hazelton, B., Thomas, L., Olma, T., Kok, J., O'Sullivan, M., Chen, S., Iredell, J. (2014). Rapid and Accurate Direct Antibiotic Susceptibility Testing of Blood Culture Broths using MALDI Sepsityper combined with the BD Phoenix Automated System. Journal of Medical Microbiology, 63, 1590-1594. [More Information]
  • Groves, M., O'Sullivan, M., Brouwers, H., Chapman, T., Abraham, S., Trott, D., Al Jassim, R., Coombs, G., Skov, R., Jordan, D. (2014). Staphylococcus aureus ST398 detected in pigs in Australia. Journal of Antimicrobial Chemotherapy, 69(5), 1426-1428. [More Information]

2013

  • Pinto, A., Seth, R., Zhou, F., Tallon, J., Dempsey, K., Tracy, M., Gilbert, G., O'Sullivan, M. (2013). Emergence and control of an outbreak of infections due to Panton-Valentine leukocidin positive, ST22 methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Clinical Microbiology and Infection, 19(7), 620-627. [More Information]
  • Hunter, M., Clezy, K., Hajkowicz, K., Hoy, J., Hume, S., O'Sullivan, M., Runnegar, N., Sasadeusz, J., Post, J. (2013). Late diagnosis of human immunodeficiency virus infection in patients with viral hepatitis. Internal Medicine Journal, 43(6), 732-734. [More Information]
  • Xiao, M., Wang, H., Zhao, Y., Mao, L., Brown, M., Yu, Y., O'Sullivan, M., Kong, F., Xu, Y. (2013). National Surveillance of Methicillin-Resistant Staphylococcus aureus in China Highlights a Still-Evolving Epidemiology with 15 Novel Emerging Multilocus Sequence Types. Journal of Clinical Microbiology, 51(11), 3638-3644. [More Information]

2012

  • O'Sullivan, M., Zhou, F., Sintchenko, V., Gilbert, G. (2012). Prospective Genotyping of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus by Use of a Novel, Highly Discriminatory Binary Typing System. Journal of Clinical Microbiology, 50(11), 3513-3519. [More Information]

2011

  • Holmes, N., Turnidge, J., Munckhof, W., Robinson, J., Korman, T., O'Sullivan, M., Anderson, T., Roberts, S., Gao, W., Christiansen, K., et al (2011). Antibiotic Choice May Not Explain Poorer Outcomes in Patients With Staphylococcus aureus Bacteremia and High Vancomycin Minimum Inhibitory Concentrations. The Journal of Infectious Diseases, 204(3), 340-347. [More Information]
  • Kok, J., O'Sullivan, M., Gilbert, G. (2011). Feedback to clinicians on preventable factors can reduce hospital onset Staphylococcus aureus bacteraemia rates. Journal of Hospital Infection, 79(2), 108-114. [More Information]
  • O'Sullivan, M., Zhou, F., Sintchenko, V., Kong, F., Gilbert, G. (2011). Multiplex PCR and Reverse Line Blot Hybridization Assay (mPCR/RLB). Journal of Visualized Experiments, 6(54), e2781-1-e2781-5. [More Information]

2010

  • O'Sullivan, M. (2010). Microbial Genotyping Systems for Infection Control. In Vitali Sintchenko (Eds.), Infectious Disease Informatics, (pp. 345-358). New York: Springer. [More Information]
  • O'Sullivan, M., Kong, F., Sintchenko, V., Gilbert, G. (2010). Rapid Identification of MRSA Transmission in Hospitals using Phage-Derived ORF Typing enhanced by Multiplex PCR and Reverse Line Blot Assay. Journal of Clinical Microbiology, 48(8), 2741-2748. [More Information]
  • Liu, Y., Kong, F., Xiao, M., Wang, Q., O'Sullivan, M., Sintchenko, V., Lin, M., Gilbert, G. (2010). Unexpected Diversity of Staphylococcal Cassette Chromosome mec Type IV in Methicillin-Resistant Staphylococcus aureus Strains. Journal of Clinical Microbiology, 48(10), 3628-3634. [More Information]

2008

  • Thomas, L., van Hal, S., O'Sullivan, M., Kyme, P., Iredell, J. (2008). Failure of the BD GeneOhm(R) StaphS/R assay for Identification of Australian Methicillin-Resistant Staphylococcus aureus strains: duplex assays remain the 'gold standard' in settings of unknown SCCmec epidemiology. Journal of Clinical Microbiology, 46(12), 4116-4117. [More Information]

2007

  • Fernandes, C., O'Sullivan, M., Cai, Y., Kong, F., Zeng, X., Gilbert, G., Kotsiou, G. (2007). An agar dilution method for the detection of inducible clindamycin resistance in Staphylococcus spp. Journal of Clinical Microbiology, 45(12), 4018-4020. [More Information]

2006

  • Ralph, A., O'Sullivan, M., Sangster, N., Walker, J. (2006). Abdominal pain and eosinophilia in suburban goat keepers - trichostrongylosis. Medical Journal of Australia, 184(9), 467-469. [More Information]
  • O'Sullivan, M., Cai, Y., Kong, F., Zeng, X., Gilbert, G. (2006). Influence of disk separation distance on accuracy of the disk approximation test for detection of inducible clindamycin resistance in Staphylococcus spp. Journal of Clinical Microbiology, 44(11), 4072-4076. [More Information]

2005

  • Coen, M., O'Sullivan, M., Bubb, W., Kuchel, P., Sorrell, T. (2005). Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis. Clinical Infectious Diseases, 41(11), 1582-1590. [More Information]

Selected Grants

2020

  • BEAT COVID, Sorrell T, Ward R, Snelling T, Snelling T, Nicholson A, Grieve S, Macartney K, O'Sullivan M, Thevarajan I, Bull R, Britton P, Cunningham A, Eden J, Smith D, Imrie A, Tang B, Brilot-Turville F, Snow Medical Research Foundation Ltd/Pandemic Response Capacity Building

2016

  • Genomics dissection and prevention of bacterial transmission events, Sintchenko V, Lan R, Holmes E, O'Sullivan M, Golubchik T, Gilbert G, National Health and Medical Research Council (NHMRC)/Project Grants