Dr Meilang Xue

Postdoctoral Research Fellow
Medicine, Northern Clinical School
Sutton Arthritis Research Laboratory

Telephone +61 2 99264816
Fax +61 2 9926 6269

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Selected grants

2013

  • Can activated protein C reverse the aggressive properties of rheumatoid synoviocytes?; Xue M, Jackson C, March L, Tonkin M; Lincoln Centre for Research into Bone & Joint Diseases/Research Support.
  • Can APC dampen the aggressive properties of RASFs; Xue M; DVC Research/Bridging Support Grant.
  • DAMPENING THE AGGRESSIVE PROPERTIES OF RHEUMATOID SYNOVIAL FIBROBLASTS TO TREAT RHEUMATOID ARTHRITIS; Jackson C, Xue M; Arthritis Australia/Project Grants.

2012

  • Differential contributions of protease activated receptor (PAR)1 and PAR2 in the aggressive properties of synovial fibroblasts in rheumatoid arthritis; Xue M, Jackson C, March L, Sambrook P, Laurent R; Royal North Shore Hospital/Staff Specialist Trust Fund.

2010

  • Activated protein C suppresses the abnormal immune response in rheumatoid arthritis; Xue M; DVC Research/Bridging Support Grant.
  • How does activated protein C create intact, non-leaky, stable blood vessels; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Activated Protein C suppresses the abnormal immune response in rheumatoid arthritis; Xue M; DVC Research/Bridging Support Grant.
  • The regulatory role of APC on arthritis; Jackson C, Xue M, Sambrook P, March L; Arthritis Australia/Project Grants.

2008

  • Activated protein C suppresses the abnormal immune response in rheumatoid arthritis; Xue M; National Health and Medical Research Council (NHMRC)/A Healthy Start to Life for All Australians.
  • Activated protein C utilises protease activated receptors and epidermal growth factor receptor to heal wounds; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Prevention of type 1 diabetes by activated protein C; Jackson C, Xue M, Fulcher G, Harrison L; Juvenile Diabetes Research Foundation/Research Grant.

2007

  • Effect of APC on pancreas; Fulcher G, Jackson C, Xue M; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.

2005

  • The role of APC in the regulation of inflammation in RA; Xue M, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
  • The role of activated protein C in rheumatoid arthritis.; University of Sydney/Postdoctoral Fellowship.

Selected publications

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Book Chapters

  • Jackson, C., Xue, M. (2011). Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In Amit Nagal (Eds.), Inflammatory Diseases - A Modern Perspective, (pp. 45-72). Rijeka: InTech Publishers.

Journals

  • Xue, M., Jackson, C. (2014). Activated protein C and its potential applications in prevention of islet β-cell damage and diabetes. Vitamins and Hormones, 95, 323-363. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), R44. [More Information]
  • Lee, Y., Jeong, J., Seol, J., Xue, M., Jackson, C., Park, S. (2013). Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Experimental and Molecular Medicine, 45, 1-7. [More Information]
  • Akbari, M., Dadadashian, F., Kordestani, S., Xue, M., Jackson, C. (2013). Enzymatic modification of regenerated cellulosic fabrics to improve bacteria sorption properties. Journal of Biomedical Materials Research. Part A, 101A (6), 1734-1742. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • Xue, M., Dervish, S., Harrison, L., Fulcher, G., Jackson, C. (2012). Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. Journal of Biological Chemistry, 287(20), 16356-16364. [More Information]
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • Xue, M., Chan, A., Shen, K., Dervish, S., March, L., Sambrook, P., Jackson, C. (2012). Protease-Activated Receptor 2, Rather Than Protease-Activated Receptor 1, Contributes to the Aggressive Properties of Synovial Fibroblasts in Rheumatoid Arthritis. Arthritis & Rheumatism, 64(1), 88-98. [More Information]
  • Xue, M., Chow, S., Dervish, S., Chan, Y., Julovi, S., Jackson, C. (2011). Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2. Journal of Biological Chemistry, 286(8), 6742-6750. [More Information]
  • Moon, M., Jeong, J., Seo, J., Seol, J., Lee, Y., Xue, M., Jackson, C., Park, S. (2011). Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. Experimental and Molecular Medicine, 43(3), 138-145. [More Information]
  • Julovi, S., Xue, M., Dervish, S., Sambrook, P., March, L., Jackson, C. (2011). Protease Activated Receptor-2 Mediates Activated Protein C–Induced Cutaneous Wound Healing via Inhibition of p38. The American Journal of Pathology: cellular and molecular biology of disease, 179(5), 2233-2242. [More Information]
  • Minhas, N., Xue, M., Fukudome, K., Jackson, C. (2010). Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. The F A S E B Journal, 24(3), 873-881. [More Information]
  • Xue, M., Minhas, N., Chow, S., Dervish, S., Sambrook, P., March, L., Jackson, C. (2010). Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and Molecular Life Sciences, 67(9), 1537-1546. [More Information]
  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis and Rheumatism, 60(3), 780-791. [More Information]
  • Xue, A., Xue, M., Jackson, C., Smith, R. (2009). Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. The International Journal of Biochemistry and Cell Biology, 41(8-9), 1731-1738. [More Information]
  • Jackson, C., Xue, M. (2008). Activated protein C-An anticoagulant that does more than stop clots. The International Journal of Biochemistry and Cell Biology, 40(12), 2692-2697. [More Information]
  • Xue, M., Jackson, C. (2008). Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. The Journal of Investigative Dermatology, 128(11), 2676-2685. [More Information]
  • Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. (2008). New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy, 8(8), 1109-1122. [More Information]
  • Wang, W., Xue, M., Willcox, M., Thakur, A. (2008). Role of Nitric Oxide in P. aeruginosa Keratitis Caused by Distinct Bacterial Phenotypes. Eye and Contact Lens, 34(4), 195-197. [More Information]
  • Whitmont, K., Reid, I., Tritton, S., March, L., Xue, M., Lee, M., Fulcher, G., Sambrook, P., Slobedman, E., Cooper, A., Jackson, C. (2008). Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology, 144(11), 1479-1483. [More Information]
  • Xue, M., Thakur, A., Cole, N., Lloyd, A., Stapleton, F., Wakefield, D., Willcox, M. (2007). A critical role for CCL2 and CCL3 chemokines in the regulation of polymorphonuclear neutrophils recruitment during corneal infection in mice. Immunology and Cell Biology, 85(7), 525-531. [More Information]
  • Xue, M., March, L., Sambrook, P., Jackson, C. (2007). Differential Regulation of Matrix Metalloproteinase 2 and Matrix Metalloproteinase 9 by Activated Protein C: Relevance to Inflammation in Rheumatoid Arthritis. Arthritis and Rheumatism, 56(9), 2864-2874. [More Information]
  • Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. (2007). Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the Rheumatic Diseases, 66(12), 1574-1580. [More Information]
  • Xue, M., Campbell, D., Jackson, C. (2007). Protein C is an autocrine growth factor for human skin keratinocytes. Journal of Biological Chemistry, 282(18), 13610-13616. [More Information]
  • Le, N., Xue, M., Castelnoble, L., Jackson, C. (2007). The dual personalities of matrix metalloproteinases in inflammation. Frontiers in Bioscience, 12, 1475-1487. [More Information]
  • Jackson, C., Xue, M. (2006). Activated protein C (APC) as a novel agent to promote wound healing. Primary Intention, 14(1), 31-34.
  • Xue, M., Thompson, P., Sambrook, P., March, L., Jackson, C. (2006). Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clinical Hemorheology and Microcirculation, 34, 153-161. [More Information]
  • Xue, M., Jackson, C., Le, N. (2006). Targeting matrix metalloproteases to improve cutaneous wound healing. Expert Opinion on Therapeutic Targets, 10(1), 143-155. [More Information]
  • Jackson, C., Xue, M., Thompson, P., Davey, R., Whitmont, K., Smith, S., Buisson-Legendre, N., Sztynda, T., Furphy, L., Cooper, A., Sambrook, P., March, L. (2005). Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair and Regeneration, 13(3), 284-294. [More Information]
  • Xue, M., Campbell, D., Sambrook, P., Fukudome, K., Jackson, C. (2005). Endothelial Protein C Receptor and Protease-Activated Receptor-1 Mediate Induction of a Wound-Healing Phenotype in Human Keratinocytes by Activated Protein C. The Journal of Investigative Dermatology, 125(6), 1279-1285. [More Information]
  • Xue, M., Thompson, P., Clifton-Bligh, R., Fulcher, G., Gallery, E., Jackson, C. (2005). Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type I diabetes. The International Journal of Biochemistry and Cell Biology, 37(11), 2406-2416. [More Information]
  • Xue, M., Thompson, P., Kelso, I., Jackson, C. (2004). Activated Protein C Stimulates Proliferation, Migration And Wound Closure, Inhibits Apoptosis And Upregulates Mmp-2 Activity In Cultured Human Keratinocytes. Experimental Cell Research: emphasizing molecular approaches to cell biology, 299(1), 119-127.

Conferences

  • Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.

2014

  • Xue, M., Jackson, C. (2014). Activated protein C and its potential applications in prevention of islet β-cell damage and diabetes. Vitamins and Hormones, 95, 323-363. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), R44. [More Information]

2013

  • Lee, Y., Jeong, J., Seol, J., Xue, M., Jackson, C., Park, S. (2013). Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Experimental and Molecular Medicine, 45, 1-7. [More Information]
  • Akbari, M., Dadadashian, F., Kordestani, S., Xue, M., Jackson, C. (2013). Enzymatic modification of regenerated cellulosic fabrics to improve bacteria sorption properties. Journal of Biomedical Materials Research. Part A, 101A (6), 1734-1742. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]

2012

  • Xue, M., Dervish, S., Harrison, L., Fulcher, G., Jackson, C. (2012). Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. Journal of Biological Chemistry, 287(20), 16356-16364. [More Information]
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • Xue, M., Chan, A., Shen, K., Dervish, S., March, L., Sambrook, P., Jackson, C. (2012). Protease-Activated Receptor 2, Rather Than Protease-Activated Receptor 1, Contributes to the Aggressive Properties of Synovial Fibroblasts in Rheumatoid Arthritis. Arthritis & Rheumatism, 64(1), 88-98. [More Information]

2011

  • Xue, M., Chow, S., Dervish, S., Chan, Y., Julovi, S., Jackson, C. (2011). Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2. Journal of Biological Chemistry, 286(8), 6742-6750. [More Information]
  • Jackson, C., Xue, M. (2011). Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In Amit Nagal (Eds.), Inflammatory Diseases - A Modern Perspective, (pp. 45-72). Rijeka: InTech Publishers.
  • Moon, M., Jeong, J., Seo, J., Seol, J., Lee, Y., Xue, M., Jackson, C., Park, S. (2011). Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. Experimental and Molecular Medicine, 43(3), 138-145. [More Information]
  • Julovi, S., Xue, M., Dervish, S., Sambrook, P., March, L., Jackson, C. (2011). Protease Activated Receptor-2 Mediates Activated Protein C–Induced Cutaneous Wound Healing via Inhibition of p38. The American Journal of Pathology: cellular and molecular biology of disease, 179(5), 2233-2242. [More Information]

2010

  • Minhas, N., Xue, M., Fukudome, K., Jackson, C. (2010). Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. The F A S E B Journal, 24(3), 873-881. [More Information]
  • Xue, M., Minhas, N., Chow, S., Dervish, S., Sambrook, P., March, L., Jackson, C. (2010). Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and Molecular Life Sciences, 67(9), 1537-1546. [More Information]

2009

  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis and Rheumatism, 60(3), 780-791. [More Information]
  • Xue, A., Xue, M., Jackson, C., Smith, R. (2009). Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. The International Journal of Biochemistry and Cell Biology, 41(8-9), 1731-1738. [More Information]

2008

  • Jackson, C., Xue, M. (2008). Activated protein C-An anticoagulant that does more than stop clots. The International Journal of Biochemistry and Cell Biology, 40(12), 2692-2697. [More Information]
  • Xue, M., Jackson, C. (2008). Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. The Journal of Investigative Dermatology, 128(11), 2676-2685. [More Information]
  • Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. (2008). New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy, 8(8), 1109-1122. [More Information]
  • Wang, W., Xue, M., Willcox, M., Thakur, A. (2008). Role of Nitric Oxide in P. aeruginosa Keratitis Caused by Distinct Bacterial Phenotypes. Eye and Contact Lens, 34(4), 195-197. [More Information]
  • Whitmont, K., Reid, I., Tritton, S., March, L., Xue, M., Lee, M., Fulcher, G., Sambrook, P., Slobedman, E., Cooper, A., Jackson, C. (2008). Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology, 144(11), 1479-1483. [More Information]

2007

  • Xue, M., Thakur, A., Cole, N., Lloyd, A., Stapleton, F., Wakefield, D., Willcox, M. (2007). A critical role for CCL2 and CCL3 chemokines in the regulation of polymorphonuclear neutrophils recruitment during corneal infection in mice. Immunology and Cell Biology, 85(7), 525-531. [More Information]
  • Xue, M., March, L., Sambrook, P., Jackson, C. (2007). Differential Regulation of Matrix Metalloproteinase 2 and Matrix Metalloproteinase 9 by Activated Protein C: Relevance to Inflammation in Rheumatoid Arthritis. Arthritis and Rheumatism, 56(9), 2864-2874. [More Information]
  • Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. (2007). Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the Rheumatic Diseases, 66(12), 1574-1580. [More Information]
  • Xue, M., Campbell, D., Jackson, C. (2007). Protein C is an autocrine growth factor for human skin keratinocytes. Journal of Biological Chemistry, 282(18), 13610-13616. [More Information]
  • Le, N., Xue, M., Castelnoble, L., Jackson, C. (2007). The dual personalities of matrix metalloproteinases in inflammation. Frontiers in Bioscience, 12, 1475-1487. [More Information]

2006

  • Jackson, C., Xue, M. (2006). Activated protein C (APC) as a novel agent to promote wound healing. Primary Intention, 14(1), 31-34.
  • Xue, M., Thompson, P., Sambrook, P., March, L., Jackson, C. (2006). Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clinical Hemorheology and Microcirculation, 34, 153-161. [More Information]
  • Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Xue, M., Jackson, C., Le, N. (2006). Targeting matrix metalloproteases to improve cutaneous wound healing. Expert Opinion on Therapeutic Targets, 10(1), 143-155. [More Information]

2005

  • Jackson, C., Xue, M., Thompson, P., Davey, R., Whitmont, K., Smith, S., Buisson-Legendre, N., Sztynda, T., Furphy, L., Cooper, A., Sambrook, P., March, L. (2005). Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair and Regeneration, 13(3), 284-294. [More Information]
  • Xue, M., Campbell, D., Sambrook, P., Fukudome, K., Jackson, C. (2005). Endothelial Protein C Receptor and Protease-Activated Receptor-1 Mediate Induction of a Wound-Healing Phenotype in Human Keratinocytes by Activated Protein C. The Journal of Investigative Dermatology, 125(6), 1279-1285. [More Information]
  • Xue, M., Thompson, P., Clifton-Bligh, R., Fulcher, G., Gallery, E., Jackson, C. (2005). Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type I diabetes. The International Journal of Biochemistry and Cell Biology, 37(11), 2406-2416. [More Information]

2004

  • Xue, M., Thompson, P., Kelso, I., Jackson, C. (2004). Activated Protein C Stimulates Proliferation, Migration And Wound Closure, Inhibits Apoptosis And Upregulates Mmp-2 Activity In Cultured Human Keratinocytes. Experimental Cell Research: emphasizing molecular approaches to cell biology, 299(1), 119-127.

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