Dr Mark Graham
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Senior Lecturer |
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Themes | Research interests | Grants | PhD & Masters' project opportunities | Honours project opportunities | Keywords
Research interests
Dr. Graham's research interests are at the interface of chemistry and biology with a view to solving medical research problems. The research is split between neuroscience and cancer research. Phosphoproteomics is being applied as a tool to advance both of these fields. In neuroscience, the molecular machinery that achieves synaptic vesicle endocytosis following neurotransmission is being studied. The synaptic protein AP180, which has a novel hybrid glyco-phospho post-translational modification, is a focus. In cancer research, the phospho-regulation of ATM kinase, a master regulator of the DNA damage response, is being studied.
Current national competitive grants*
2009
Inhibitory signaling switches define the machinery of synaptic vesicle endocytosis
Graham M
NHMRC Career Development Awards ($370,000 over 4 years)
* Grants administered through the University of Sydney
PhD and Masters' project opportunities
A novel post-translational modification, O-GlcNAc-phosphate, has a regulatory role in neurotransmission
The kinetics of the endocytic phosphoproteome during synaptic vesicle recycling
Why is O-GlcNAc used as a major signalling mechanism in nerve terminals?
Kinomic analysis of the DNA damage response.
Honours project opportunities
The functional role of a new post-transaltional modification in synaptic vesicle endocytosis.