Dr Michael Lee

PhD, MPhty, MChiro, BSc
Lecturer, Discipline of Physiotherapy
O Block, Room O204

Telephone + 61 2 9351 9266
Fax + 61 2 9351 9278

Website ForeFront Motor Neurone Disease Clinic, Brain & Mind Research Institute
Neurological Rehabilitation Research Group
Arthritis and Musculoskeletal Research Group

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Biographical details

Dr Lee is a Clinical Neurophysiologist and a full-time academic staff in the Discipline of Physiotherapy. Dr Lee has a PhD in Neuroscience obtained from the Faculty of Medicine at the University of New South Wales (UNSW) as well as clinical qualifications in Physiotherapy (University of Queensland) and Chiropractic (Macquarie University). Dr Lee completed his Post-doctoral training in Clinical Neurology (in spinal cord injury rehabilitation and Amyotrophic Lateral Sclerosis / Motor Neurone Disease) with Professor Matthew Kiernan at the Brain & Mind Center and Neuroscience Research Australia.

Dr Lee was a Lecturer in Neurology at Macquarie University (2010-2011) and a Lecturer in Exercise Physiology at UNSW (2008-2010) before joining the Discipline of Physiotherapy in 2015.

Dr Lee is a Research Affiliate at the Brain & Mind Center, Neuroscience Research Australia and the Department of Cognitive Science at Macquarie University and a Neurology Research Fellow at the Institute of Neurological Sciences and the Pain Management Unit at the Prince of Wales Hospital. He conducts clinical research in patients with motor neurone disease, spinal cord injury and neuropathic pain.

Research interests

Dr Lee’s research interest is in clinical neurology, particularly disease pathophysiology and the role of physical therapy and exercise in motor neurone disease, spinal cord injury, neuropathic pain and peripheral neuropathy.

Michael has research expertise in a number of novel and sophisticated neurophysiological techniques including transcranial magnetic stimulation (TMS), peripheral nerve stimulation, nerve excitability, twitch interpolation, magnetoencephalography (MEG) and electroencephalography (EEG).

Teaching and supervision

Michael lectures in neurological physiotherapy and musculoskeletal physiotherapy in the Faculty of Health Sciences.

Current projects

  • Exploring cortical processing of motor imagery in early Amyotrophic Lateral Sclerosis using magnetoencephalography (MEG).
  • Mechanisms underlying exercise-induced neuroprotection in patients with Amyotrophic Lateral Sclerosis.
  • Electrophysiological biomarkers of spinal circuitry in Amyotrophic Lateral Sclerosis.
  • Effects of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) in chronic pain.
  • Peripheral nerve stimulation and axonal dysfunction after spinal cord injury.
  • Does spinal manipulation modulate sympathetic nerve activity in humans?

Associations

  • Member of the Australian Physiotherapy Association
  • Member of the Australian Neuroscience Society
  • Member of Australian Pain Society
  • Member of Exercise and Sports Science Australia
  • Member of the Chiropractic and Osteopathic College of Australasia
  • Governor of the Sydney College of Chiropractic

Awards and honours

  • 2012-2014 Applied Spinal Cord Injury Research Fellowship, New South Wales Office for Medical Research. For the project titled “Utilising plasticity of the neural axis in patients with Spinal Cord Injury to drive improved functional recovery”
  • 2012-2014 Bill Gole Motor Neuron Disease Postdoctoral Fellowship, Motor Neurone Disease Research Institute of Australia. For the project titled “Mechanisms underlying exercise-induced neuroprotection in patients with Amyotrophic Lateral Sclerosis”
  • 2012-2014 Visiting Fellowship, School of Biomedical Sciences and Pharmacy, University of Newcastle
  • 2010-2012 Travelling Fellowship, New Zealand Colleague of Chiropractic, Auckland New Zealand
  • 2004-2008 ARC Human Motor Control PhD Scholarship, UNSW
  • 2007 University of New South Wales Postgraduate Travel Grant ($3000)
  • 2006 Australasian Winter Conference on Brain Research Travel Grant ($2000)
  • 2005 Australian Neuroscience Society Travel Grant ($500)

Selected grants

2016

  • Dissecting the mechanisms underlying muscle fatigue in ALS using acute and cumulative resistance exercise; Lee M, Kiernan M, Swash M, Canning C; Motor Neurone Disease Research Institute of Australia/Grants in aid.

2015

  • Travel to attend the annual International MND/ALS Symposium - Orlando 2015; Lee M; Motor Neurone Disease Associaton of Victoria (MND Victoria)/Nina Buscombe Award.

2012

  • Spinal Cord Injury and Related Neurological Conditions Research Grants Program; Lee M; New South Wales Office for Medical Research/Research Grant.
  • The Bill Gole Motor Neuron Disease Postdoctoral Fellowship; Lee M; Motor Neurone Disease Research Institute of Australia/Postdoctoral Fellowship.

2011

  • Australian Brain Foundation Project Grant; Lee M; Australian Brain Foundation/Research Grant.

2010

  • Hamblin New Zealand Chiropractic Research Trust Fund; Lee M; New Zealand Chiropractors Association (NZCA)/Research Grant.

Selected publications

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Book Chapters

  • Huynh, W., Lee, M., Kiernan, M. (2015). Neurorehabilitation approaches for disorders of the peripheral nervous system. In Volker Dietz, Nick Ward (Eds.), The Oxford Textbook of Neurorehabilitation, (pp. 224-237). Oxford: Oxford University Press.

Journals

  • Lee, M., Teber, E., Holmes, O., Nones, K., Patch, A., Dagg, R., Lau, L., Lee, J., Napier, C., Arthur, J., Hayward, N., Mann, G., Scolyer, R., Wilmott, J., Reddel, R., Pickett, H., et al (2018). Telomere sequence content can be used to determine ALT activity in tumours. Nucleic Acids Research, 46, 4903-4918. [More Information]
  • Simon, N., Lee, M., Bae, J., Mioshi, E., Lin, C., Pfluger, C., Henderson, R., Vucic, S., Swash, M., Burke, D., Kiernan, M. (2015). Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis. Journal of Neurology, 262(6), 1424-1432. [More Information]
  • Simon, N., Lin, C., Lee, M., Howells, J., Vucic, S., Burke, D., Kiernan, M. (2015). Segmental motoneuronal dysfunction is a feature of amyotrophic lateral sclerosis. Clinical Neurophysiology, 126(4), 828-836. [More Information]
  • Lee, M., Kiernan, M., Macefield, V., Lee, B., Lin, C. (2015). Short-term peripheral nerve stimulation ameliorates axonal dysfunction after spinal cord injury. Journal of Neurophysiology, 113, 3209-3218. [More Information]
  • Pickering, H., Lee, M., Moseley, G., Minei, P., Lin, C. (2012). Sensory disturbances evoked by immobilization of an experimentally inflamed limb. Clinical Neurophysiology, 123(7), e71-e72. [More Information]
  • Lee, M., Hinder, M., Gandevia, S., Carroll, T. (2010). The ipsilateral motor cortex contributes to cross-limb transfer of ballistic motor learning. Journal of Physiology, 588(1), 201-212. [More Information]
  • Lee, M., Hinder, M., Gandevia, S., Carroll, T. (2010). The ipsilateral motor cortex contributes to cross-limb transfer of ballistic motor learning. Journal of Physiology, 588(1), 202-212. [More Information]
  • Lee, M., Gandevia, S., Carroll, T. (2009). Short-term strength training does not change cortical voluntary activation. Medicine and Science in Sports and Exercise, 41(7), 1452-1460. [More Information]
  • Carroll, T., Barton, J., Hsu, M., Lee, M. (2009). The effect of strength training on the force of twitches evoked by corticospinal stimulation in humans. Acta Physiologica, 197(2), 161-173. [More Information]
  • Lee, M., Gandevia, S., Carroll, T. (2009). Unilateral strength training increases voluntary activation of the opposite untrained limb. Clinical Neurophysiology, 120(4), 802-808. [More Information]
  • Lee, M., Gandevia, S., Carroll, T. (2008). Cortical voluntary activation can be reliably measured in human wrist extensors using transcranial magnetic stimulation. Clinical Neurophysiology, 119(5), 1130-1138. [More Information]
  • Carroll, T., Lee, M., Hsu, M., Sayde, J. (2008). Unilateral practice of a ballistic movement causes bilateral increases in performance and corticospinal excitability. Journal of Applied Physiology, 104(6), 1656-1664. [More Information]
  • Lee, M., Carroll, T. (2007). Cross education: Possible mechanisms for the contralateral effects of unilateral resistance training. Sports Medicine, 37(1), 1-14. [More Information]
  • Carroll, T., Herbert, R., Munn, J., Lee, M., Gandevia, S. (2006). Contralateral effects of unilateral strength training: evidence and possible mechanisms. Journal of Applied Physiology, 101(5), 1514-1522. [More Information]
  • Lee, M., Carroll, T. (2005). The amplitude of Mmax in human wrist flexors varies during different muscle contractions despite constant posture. Journal of Neuroscience Methods, 149(2), 95-100. [More Information]

Conferences

  • Lee, M., Meng, D., Kiernan, M., Johnson, B. (2015). Exploring motor imagery and motor cortical function in ALS using magnetoencephalography. 16th Biennial Clinical Neurophysiology Workshop of the Australian and New Zealand Association of Neurologists, Australia.
  • Lee, M., Meng, D., Kiernan, M., Johnson, B. (2015). Exploring motor imagery and motor cortical function in ALS using magnetoencephalography. Asia Pacific FTD & MND Meeting, Australia.
  • Lee, M., Meng, D., Kiernan, M., Johnson, B. (2015). Exploring motor imagery and motor cortical function in ALS using MEG. 26th International Symposium on ALS/MND, Orlando USA.
  • Lee, M., Kiernan, M., Macefield, V., Lee, B., Lin, C. (2015). Nerve excitability changes in SCI patients after high-frequency repetitive peripheral nerve stimulation. International Taiwanese Congress of Neurology, Taiwan.
  • Lee, M., Lance, J., Burke, D., Fitzpatrick, R., Simon, N., Kiernan, M. (2014). Vibration-induced H-reflex inhibition is suppressed in ALS – A biomarker for upper motor neuron dysfunction? International Motoneuron Meeting, Canada.
  • Lee, M., Lance, J., Burke, D., Fitzpatrick, R., Simon, N., Kiernan, M. (2014). Vibration-induced H-reflex inhibition is suppressed in ALS – A biomarker for upper motor neuron dysfunction? 25th International ALS/MND Symposium.

2018

  • Lee, M., Teber, E., Holmes, O., Nones, K., Patch, A., Dagg, R., Lau, L., Lee, J., Napier, C., Arthur, J., Hayward, N., Mann, G., Scolyer, R., Wilmott, J., Reddel, R., Pickett, H., et al (2018). Telomere sequence content can be used to determine ALT activity in tumours. Nucleic Acids Research, 46, 4903-4918. [More Information]

2015

  • Simon, N., Lee, M., Bae, J., Mioshi, E., Lin, C., Pfluger, C., Henderson, R., Vucic, S., Swash, M., Burke, D., Kiernan, M. (2015). Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis. Journal of Neurology, 262(6), 1424-1432. [More Information]
  • Lee, M., Meng, D., Kiernan, M., Johnson, B. (2015). Exploring motor imagery and motor cortical function in ALS using magnetoencephalography. 16th Biennial Clinical Neurophysiology Workshop of the Australian and New Zealand Association of Neurologists, Australia.
  • Lee, M., Meng, D., Kiernan, M., Johnson, B. (2015). Exploring motor imagery and motor cortical function in ALS using magnetoencephalography. Asia Pacific FTD & MND Meeting, Australia.
  • Lee, M., Meng, D., Kiernan, M., Johnson, B. (2015). Exploring motor imagery and motor cortical function in ALS using MEG. 26th International Symposium on ALS/MND, Orlando USA.
  • Lee, M., Kiernan, M., Macefield, V., Lee, B., Lin, C. (2015). Nerve excitability changes in SCI patients after high-frequency repetitive peripheral nerve stimulation. International Taiwanese Congress of Neurology, Taiwan.
  • Huynh, W., Lee, M., Kiernan, M. (2015). Neurorehabilitation approaches for disorders of the peripheral nervous system. In Volker Dietz, Nick Ward (Eds.), The Oxford Textbook of Neurorehabilitation, (pp. 224-237). Oxford: Oxford University Press.
  • Simon, N., Lin, C., Lee, M., Howells, J., Vucic, S., Burke, D., Kiernan, M. (2015). Segmental motoneuronal dysfunction is a feature of amyotrophic lateral sclerosis. Clinical Neurophysiology, 126(4), 828-836. [More Information]
  • Lee, M., Kiernan, M., Macefield, V., Lee, B., Lin, C. (2015). Short-term peripheral nerve stimulation ameliorates axonal dysfunction after spinal cord injury. Journal of Neurophysiology, 113, 3209-3218. [More Information]

2014

  • Lee, M., Lance, J., Burke, D., Fitzpatrick, R., Simon, N., Kiernan, M. (2014). Vibration-induced H-reflex inhibition is suppressed in ALS – A biomarker for upper motor neuron dysfunction? International Motoneuron Meeting, Canada.
  • Lee, M., Lance, J., Burke, D., Fitzpatrick, R., Simon, N., Kiernan, M. (2014). Vibration-induced H-reflex inhibition is suppressed in ALS – A biomarker for upper motor neuron dysfunction? 25th International ALS/MND Symposium.

2012

  • Pickering, H., Lee, M., Moseley, G., Minei, P., Lin, C. (2012). Sensory disturbances evoked by immobilization of an experimentally inflamed limb. Clinical Neurophysiology, 123(7), e71-e72. [More Information]

2010

  • Lee, M., Hinder, M., Gandevia, S., Carroll, T. (2010). The ipsilateral motor cortex contributes to cross-limb transfer of ballistic motor learning. Journal of Physiology, 588(1), 201-212. [More Information]
  • Lee, M., Hinder, M., Gandevia, S., Carroll, T. (2010). The ipsilateral motor cortex contributes to cross-limb transfer of ballistic motor learning. Journal of Physiology, 588(1), 202-212. [More Information]

2009

  • Lee, M., Gandevia, S., Carroll, T. (2009). Short-term strength training does not change cortical voluntary activation. Medicine and Science in Sports and Exercise, 41(7), 1452-1460. [More Information]
  • Carroll, T., Barton, J., Hsu, M., Lee, M. (2009). The effect of strength training on the force of twitches evoked by corticospinal stimulation in humans. Acta Physiologica, 197(2), 161-173. [More Information]
  • Lee, M., Gandevia, S., Carroll, T. (2009). Unilateral strength training increases voluntary activation of the opposite untrained limb. Clinical Neurophysiology, 120(4), 802-808. [More Information]

2008

  • Lee, M., Gandevia, S., Carroll, T. (2008). Cortical voluntary activation can be reliably measured in human wrist extensors using transcranial magnetic stimulation. Clinical Neurophysiology, 119(5), 1130-1138. [More Information]
  • Carroll, T., Lee, M., Hsu, M., Sayde, J. (2008). Unilateral practice of a ballistic movement causes bilateral increases in performance and corticospinal excitability. Journal of Applied Physiology, 104(6), 1656-1664. [More Information]

2007

  • Lee, M., Carroll, T. (2007). Cross education: Possible mechanisms for the contralateral effects of unilateral resistance training. Sports Medicine, 37(1), 1-14. [More Information]

2006

  • Carroll, T., Herbert, R., Munn, J., Lee, M., Gandevia, S. (2006). Contralateral effects of unilateral strength training: evidence and possible mechanisms. Journal of Applied Physiology, 101(5), 1514-1522. [More Information]

2005

  • Lee, M., Carroll, T. (2005). The amplitude of Mmax in human wrist flexors varies during different muscle contractions despite constant posture. Journal of Neuroscience Methods, 149(2), 95-100. [More Information]

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