Associate Professor Michael Valenzuela

Associate Professor
Brain & Mind Research Institute, Sydney Medical School

Telephone 02 9114 4135

Map

Current research students

Project title Research student
Validating novel technologies for indoor spatial tracking as a functional assessment for older adults Verity CHADWICK
Booster Brain Training in Day Centres Harry HALLOCK
Computerised Cognitive Training in Insidious Late Life Cognitive Decline. Isabella LEUNG
Understanding migration of adult human skin-derived neural precursors. An TRUONG

Selected grants

2017

  • SOAR proposal - Valenzuela, Michael; Valenzuela M; DVC Research/SOAR Fellowships.

2016

  • Confocal Microscopes - live cell imaging and routine scanning; Halliday G, Valenzuela M, Arnold J; DVC Research/Equipment Grant.
  • The DOGS+CELLS Trial: A new pathway to treating Alzheimer's dementia; Duncan T, Valenzuela M; Equity Trustees Limited/Mason Foundation National Medical Research.
  • Regenerative Neuroscience Strategies for Healthy Brain Ageing and Dementia; Valenzuela M; National Health and Medical Research Council (NHMRC)/Career Development Fellowships.
  • The Tasmanian Healthy Brain Project: a longitudinal intervention study to reduce the risk of ageing-related cognitive decline and dementia; Vickers J, Valenzuela M; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • Maintain Your Brain; Brodaty H, Valenzuela M, Sachdev P, McNeil J, Maeder A, Lautenschlager N, Jorm L, Fiatarone Singh M, Anstey K, Andrews G; National Health and Medical Research Council (NHMRC)/Dementia Research Team Grants.
  • In-home Spatial Tracking: Moving Behavioural Neuroscience into the Home; Valenzuela M, Balleine B, Ramos F, Brodaty H; DVC Research/HMR+ Implementation Fund - University.
  • Regenerative Neuroscience Strategies for Brain Ageing & Dementia II; Valenzuela M; DVC Research/Bridging Support Fellowship.
  • Partial Fellowship - Regenerative Neuroscience Strategies for Brain & Mind Ageing; Valenzuela M; University of Sydney/Internal Scheme.
  • A randomised controlled trial of cognitive-only and cognitive-motor training to prevent falls in older people: understanding physical, neuropsychological and neural mechanisms; Valenzuela M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Modifying the Trajectory of Insidious Late Life Cognitive Decline using Computerised Cognitive Training; Valenzuela M, Naismith S; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Regenerative Neuroscience Strategies for Brain Ageing and Dementia; Valenzuela M; National Health and Medical Research Council (NHMRC)/Career Development Fellowships.
  • Neurogenesis in Depression using Magnetic Resonance Spectroscopy; Valenzuela M, Yucel M, Velakoulis D, Dragunow M, Loo C, Pujol J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Which Mental Activities and When for Dementia Prevention The Four Nations Longitudinal Collaboration; Valenzuela M, Ritchie K, Brayne C, Stern Y; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Role of Neurogenesis in Clinical Recovery from Depression during ECT: Application of a Novel in vivo Magnetic Resonance Spectoscopy Technology; Valenzuela M; National Health and Medical Research Council (NHMRC)/Career Development Awards.
  • The Healthy Brain Project: A prospective cohort study to examine how later-life university education may affect the trajectory of ageing-related cognitive decline; Valenzuela M; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Detection and induction of in vivo neurogenesis in humans using a novel magnetic resonance spectroscopy technique; Valenzuela M; Pfizer/Research Grant.
  • Boosting the Mental Wealth and Cognitive Capacity of Working Australians; Valenzuela M; The Brain Department Pty Ltd./Research Support.
  • Skin derived neural stem cells for Alzheimers Disease - in vivo studies; Valenzuela M; Rebecca L Cooper Medical Research Foundation/Research Grant.

2009

  • Microstructure of Brain Reserve; Valenzuela M; UNSW/Goldstar Research Grant.
  • Post Doctural Fellow grant; Valenzuela M; UNSW/Faculty of Medicine Post Doctoral Fellow Grant.

2008

  • THE SMART Trial - Study of Mental Activity and Regular Training; Valenzuela M; National Health and Medical Research Council (NHMRC)/Dementia Research Team Grants.
  • Skin derived neural stem cells for reversal of age-associated cognitive impairment; Valenzuela M; Mason Foundation/Mason Foundation Research Grants Program.

Selected publications

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Books

  • Valenzuela, M. (2011). Maintain Your Brain: What you can do to improve your brains health and avoid dementia. Sydney, Australia: ABC Books.
  • Valenzuela, M. (2009). Its Never Too Late to Change Your Mind: The Latest Medical Thinking on What You Can Do to Avoid Dementia. Sydney: ABC Books.

Book Chapters

  • Lampit, A., Duffy, S., Valenzuela, M. (2016). Physical exercise for brain health in later life: how does it work? In Linda C. W. Lam, Michelle Riba (Eds.), Physical Exercise Interventions for Mental Health, (pp. 147-163). Cambridge: Cambridge University Press.
  • Suo, C., Valenzuela, M. (2012). Neuroimaging Outcomes of Brain Training Trials. In Prof. Peter Bright (Eds.), Neuroimaging - Cognitive and Clinical Neuroscience, (pp. 417-430). Rijeka, Croatia: Intech.
  • Valenzuela, M. (2011). The Changing Brain. In Helen Sykes (Eds.), HEALTH, (pp. 174-185). Melbourne: Future Leaders.

Journals

  • Hallock, H., Collins, D., Lampit, A., Deol, K., Fleming, J., Valenzuela, M. (2016). Cognitive Training for Post-Acute Traumatic Brain Injury: A Meta-Analysis. Frontiers in Human Neuroscience, 10, Article 537. [More Information]
  • Hill, N., Mowszowski, L., Naismith, S., Chadwick, V., Valenzuela, M., Lampit, A. (2016). Computerized Cognitive Training In Older Adults With Mild Cognitive Impairment Or Dementia: A Systematic Review And Meta-Analysis. The American Journal of Psychiatry, Published ahead of print.
  • Mavros, Y., Gates, N., Wilson, G., Jain, N., Meiklejohn, J., Brodaty, H., Wen, W., Singh, N., Baune, B., Suo, C., Baker, M., Foroughi, N., Wang, Y., Valenzuela, M., Fiatarone Singh, M., et al (2016). Mediation of Cognitive Function Improvements by Strength Gains After Resistance Training in Older Adults with Mild Cognitive Impairment: Outcomes of the Study of Mental and Resistance Training. Journal of the American Geriatrics Society, 2016 (Article in press). [More Information]
  • Suo, C., Gates, N., Singh, M., Saigal, N., Wilson, G., Meiklejohn, J., Sachdev, P., Brodaty, H., Wen, W., Singh, N., Baker, M., Foroughi, N., Valenzuela, M., et al (2016). Midlife managerial experience is linked to late life hippocampal morphology and function. Brain Imaging and Behavior, Article in press. [More Information]
  • Truong, N., Si, E., Duncan, T., Valenzuela, M. (2016). Modeling neurodegenerative disorders in adult somatic cells: A critical review. Frontiers in Biology, 11(3), 232-245. [More Information]
  • Lavrencic, L., Kurylowicz, L., Valenzuela, M., Churches, O., Keage, H. (2016). Social cognition is not associated with cognitive reserve in older adults. Aging, Neuropsychology, and Cognition, 23(1), 61-77. [More Information]
  • Suo, C., Fiatarone Singh, M., Gates, N., Wen, W., Sachdev, P., Brodaty, H., Saigal, N., Wilson, G., Meiklejohn, J., Singh, N., Baker, M., Mavros, Y., Lampit, A., Leung, I., et al (2016). Therapeutically Relevant Structural and Functional Mechanisms Triggered by Physical and Cognitive Exercise. Molecular Psychiatry, 216, 1633-1642. [More Information]
  • Leung, I., Walton, C., Hallock, H., Lewis, S., Valenzuela, M., Lampit, A. (2015). Cognitive training in Parkinson disease: A systematic review and meta-analysis. Neurology, 85(21), 1843-1851. [More Information]
  • Lampit, A., Hallock, H., Suo, C., Naismith, S., Valenzuela, M. (2015). Cognitive training-induced short-term functional and long-term structural plastic change is related to gains in global cognition in healthy older adults: a pilot study. Frontiers in Aging Neuroscience, 7, 1-13. [More Information]
  • Lampit, A., Valenzuela, M., Gates, N. (2015). Computerized Cognitive Training Is Beneficial for Older Adults. Journal of the American Geriatrics Society, 63(12), 2610-2612. [More Information]
  • Lowe, A., Dalton, M., Sidhu, K., Sachdev, P., Reynolds, B., Valenzuela, M. (2015). Neurogenesis and precursor cell differences in the dorsal and ventral adult canine hippocampus. Neuroscience Letters, 593, 107-113. [More Information]
  • Lampit, A., Valenzuela, M. (2015). Pointing the FINGER at multimodal dementia prevention. The Lancet, 386(10004), 1625-1626. [More Information]
  • Valenzuela, M., Turner, L., Kochan, N., Wen, W., Suo, C., Hallock, H., Mcintosh, R., Sachdev, P., Breakspear, M. (2015). Posterior compensatory network in cognitively intact elders with hippocampal atrophy. Hippocampus, 25(5), 581-593. [More Information]
  • Fiatarone Singh, M., Gates, N., Saigal, N., Wilson, G., Meiklejohn, J., Brodaty, H., Wen, W., Baker, M., Singh, N., Suo, C., et al (2015). Reply to the Letter to the Editor by O'Caoimh et al. Journal of the American Medical Directors Association (JAMDA), 16(11), 999-1001. [More Information]
  • Lampit, A., Valenzuela, M., Gates, N. (2015). Response to Dr. Edward Ratner et al. Journal of the American Geriatrics Society, 63(12), 2615-2615. [More Information]
  • Carrasco, J., Georgevsky, D., Valenzuela, M., McGreevy, P. (2014). A pilot study of sexual dimorphism in the head morphology of domestic dogs. Journal of Veterinary Behavior, 9(1), 43-46. [More Information]
  • Stuart, K., Summers, M., Valenzuela, M., Vickers, J. (2014). BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults. Neurobiology of Learning and Memory, 110, 1-7. [More Information]
  • Bennett, D., Arnold, S., Valenzuela, M., Brayne, C., Schneider, J. (2014). Cognitive and social lifestyle: Links with neuropathology and cognition in late life. Acta Neuropathologica, 127(1), 137-150. [More Information]
  • Lampit, A., Hallock, H., Valenzuela, M. (2014). Computerized Cognitive Training in Cognitively Healthy Older Adults: A Systematic Review and Meta-Analysis of Effect Modifiers. PLoS Medicine, 11(11), 1-18. [More Information]
  • Georgevsky, D., Carrasco, J., Valenzuela, M., McGreevy, P. (2014). Domestic dog skull diversity across breeds , breed groupings and genetic clusters. Journal of Veterinary Behavior, 9(5), 228-234. [More Information]
  • Kolanowski, A., Hill, N., Kurum, E., Fick, D., Yevchak, A., Mulhall, P., Clare, L., Valenzuela, M. (2014). Gender Differences in Factors Associated With Delirium Severity in Older Adults With Dementia. Archives of Psychiatric Nursing, 28(3), 187-192. [More Information]
  • Hong, A., Suo, C., Valenzuela, M., Haydu, L., Jacobsen, K., Reisse, C., Fogarty, G. (2014). Low incidence of melanoma brain metastasis in the hippocampus. Radiotherapy and Oncology, 111(1), 59-62. [More Information]
  • Lampit, A., Ebster, C., Valenzuela, M. (2014). Multi-domain computerized cognitive training program improves performance of bookkeeping tasks: a matched-sampling active-controlled trial. Frontiers in Psychology, 5, 1-7. [More Information]
  • Gates, N., Valenzuela, M., Sachdev, P., Fiatarone Singh, M. (2014). Psychological well-being in individuals with mild cognitive impairment. Clinical Interventions in Aging, 9, 779-792. [More Information]
  • Fiatarone Singh, M., Gates, N., Saigal, N., Wilson, G., Meiklejohn, J., Brodaty, H., Wen, W., Singh, N., Baune, B., Suo, C., Baker, M., Foroughi, N., Valenzuela, M., et al (2014). The Study of Mental and Resistance Training (SMART) Study-Resistance Training and/or Cognitive Training in Mild Cognitive Impairment: A Randomized, Double-Blind, Double-Sham Controlled Trial. Journal of the American Medical Directors Association (JAMDA), 15(12), 873-880. [More Information]
  • Lampit, A., Hallock, H., Moss, R., Kwok, S., Rosser, M., Lukjanenko, M., Kohn, A., Naismith, S., Brodaty, H., Valenzuela, M. (2014). The Timecourse of Global Cognitive Gains from Supervised Computer-Assisted Cognitive Training: A Randomised, Active-Controlled Trial in Elderly with Multiple Dementia Risk Factors. The Journal of Prevention of Alzheimer's Disease, 1(1), 33-39.
  • Siette, J., Westbrook, R., Cotman, C., Sidhu, K., Zhu, W., Sachdev, P., Valenzuela, M. (2013). Age-Specific Effects of Voluntary Exercise on Memory and the Older Brain. Biological Psychiatry, 73(5), 435-442. [More Information]
  • Valenzuela, M., Leon, I., Suo, C., Martinez Piamba, D., Kochan, N., Brodaty, H., Sachdev, P. (2013). Cognitive Lifestyle in Older Persons: The Population-Based Sydney Memory & Ageing Study. Journal of Alzheimer's Disease, 36(1), 87-97. [More Information]
  • McGreevy, P., Georgevsky, D., Carrasco, J., Valenzuela, M., Duffy, D., Serpell, J. (2013). Dog Behavior Co-Varies with Height, Bodyweight and Skull Shape. PloS One, 8(12), 1-7. [More Information]
  • Valenzuela, M., Bartres-Faz, D., Bullmore, E., Fjell, A., Maletic-Savetic, M., Martins, R., Solowij, N., Yucel, M. (2013). More thinking about less data: a perspective from the 2nd Provence Summer Workshop. Molecular Psychiatry, 18(5), 524-525. [More Information]
  • Borness, C., Proudfoot, J., Crawford, J., Valenzuela, M. (2013). Putting Brain Training to the Test in the Workplace: A Randomized, Blinded, Multisite, Active-Controlled Trial. PloS One, 8(3), 1-8. [More Information]
  • Gates, N., Fiatarone Singh, M., Sachdev, P., Valenzuela, M. (2013). The Effect of Exercise Training on Cognitive Function in Older Adults with Mild Cognitive Impairment: A Meta-analysis of Randomized Controlled Trials. American Journal of Geriatric Psychiatry, 21(11), 1086-1097. [More Information]
  • Summers, M., Saunders, N., Valenzuela, M., Summers, J., Ritchie, K., Robinson, A., Vickers, J. (2013). The Tasmanian Healthy Brain Project (THBP): a prospective longitudinal examination of the effect of university-level education in older adults in preventing age-related cognitive decline and reducing the risk of dementia. International Psychogeriatrics, 25(7), 1145-1155. [More Information]
  • Marioni, R., van den Hout, A., Valenzuela, M., Brayne, C., Matthews, F. (2012). Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline. Journal of Alzheimer's Disease, 28(1), 223-230. [More Information]
  • Marioni, R., Valenzuela, M., van den Hout, A., Brayne, C., Matthews, F. (2012). Active cognitive lifestyle is associated with positive cognitive health transitions and compression of morbidity from age sixty-five. PloS One, 7(12), 1-6. [More Information]
  • Valenzuela, M., Esler, M., Ritchie, K., Brodaty, H. (2012). Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention. Translational Psychiatry, 2, 1-10. [More Information]
  • Valenzuela, M. (2012). Brain and heart targets for better dementia prevention. Medicine Today, 13(2), 38-43.
  • Salvin, H., MaGrath, C., McGreevy, P., Valenzuela, M. (2012). Development of a novel paradigm for the measurement of olfactory discrimination in dogs (Canis familiaris): A pilot study. Journal of Veterinary Behavior, 7(1), 3-10. [More Information]
  • Borness, C., Proudfoot, J., Valenzuela, M. (2012). Methodological Challenges and Solutions When Conducting a Multicenter, Online, Randomized Controlled Trial of Brain Training Within a Public Service Organization. Journal of Workplace Behavioral Health, 27(4), 272-288. [More Information]
  • Valenzuela, M., Matthews, F., Brayne, C., Ince, P., Halliday, G., Kril, J., Dalton, M., Richardson, K., Forster, G., Sachdev, P. (2012). Multiple Biological Pathways Link Cognitive Lifestyle to Protection from Dementia. Biological Psychiatry, 71(9), 783-791. [More Information]
  • Suo, C., Leon, I., Brodaty, H., Troller, J., Wen, W., Sachdev, P., Valenzuela, M. (2012). Supervisory experience at work is linked to low rate of hippocampal atrophy in late life. NeuroImage, 63(3), 1542-1551. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2012). The effect of breed on age-related changes in behavior and disease prevalence in cognitively normal older community dogs, canis lupus familiaris. Journal of Veterinary Behavior, 7(2), 61-69. [More Information]
  • Gates, N., Sachdev, P., Fiatarone Singh, M., Valenzuela, M. (2011). Cognitive and memory training in adults at risk of dementia: A Systematic Review. BMC Geriatrics, 11, 1-14. [More Information]
  • Valenzuela, M., Brayne, C., Sachdev, P., Wilcock, G., Matthews, F. (2011). Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort. American Journal of Epidemiology, 173(9), 1004-1012. [More Information]
  • Kochan, N., Breakspear, M., Valenzuela, M., Slavin, M., Brodaty, H., Wen, W., Trollor, J., Turner, A., Crawford, J., Sachdev, P. (2011). Cortical responses to a graded working memory challenge predict functional decline in mild cognitive impairment. Biological Psychiatry, 70(2), 123-130. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2011). Growing old gracefully - Behavioral changes associated with "successful aging" in the dog, Canis familaris. Journal of Veterinary Behavior, 6(6), 313-320. [More Information]
  • Kochan, N., Valenzuela, M., Slavin, M., McCraw, S., Sachdev, P., Breakspear, M. (2011). Impact of load-related neural processes on feature binding in visuospatial working memory. PloS One, 6(8), 1-14. [More Information]
  • Song, F., Poljak, A., Valenzuela, M., Mayeux, R., Smythe, G., Sachdev, P. (2011). Meta-analysis of plasma amyloid-beta levels in alzheimer's disease. Journal of Alzheimer's Disease, 26(2), 365-375. [More Information]
  • Gates, N., Valenzuela, M., Sachdev, P., Singh, N., Baune, B., Brodaty, H., Suo, C., Jain, N., Wilson, G., Wang, Y., Baker, M., Williamson, D., Foroughi, N., Fiatarone Singh, M. (2011). Study of Mental Activity and Regular Training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial. BMC Geriatrics, 11(19), 1-15. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2011). The canine cognitive dysfunction rating scale (CCDR): A data-driven and ecologically relevant assessment tool. The Veterinary Journal, 188(3), 331-336. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2011). The Canine Sand Maze: An Appetitive Spatial Memory Paradigm Sensitive To Age-Related Changes in Dog. Journal of the Experimental Analysis of Behavior, 95(1), 109-118. [More Information]
  • Gates, N., Valenzuela, M. (2010). Cognitive exercise and its role in cognitive function in older adults. Current Psychiatry Reports, 12(1), 20-27. [More Information]
  • Kochan, N., Breakspear, M., Slavin, M., Valenzuela, M., McCraw, S., Brodaty, H., Sachdev, P. (2010). Functional alterations in brain activation and deactivation in mild cognitive impairment in response to a graded working memory challenge. Dementia and Geriatric Cognitive Disorders, 30(6), 553-568. [More Information]
  • Roberts, T., McGreevy, P., Valenzuela, M. (2010). Human Induced Rotation and Reorganization of the Brain of Domestic Dogs. PloS One, 5(7), 1-7. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2010). Under diagnosis of canine cognitive dysfunction: A cross-sectional survey of older companion dogs. The Veterinary Journal, 184, 277-281. [More Information]
  • Valenzuela, M., Sachdev, P., Wen, W., Chen, X., Brodaty, H. (2008). Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy. PloS One, 3(7), 1-6. [More Information]
  • Brodaty, H., Sachdev, P., Withall, A., Altendorf, A., Valenzuela, M., Lorentz, L. (2005). Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke -the Sydney Stroke Study. Psychological Medicine, 35(12), 1707-1716.
  • Valenzuela, M., Jones, M., Wen, W., Rae, C., Graham, S., Shnier, R., Sachdev, P. (2003). Memory training alters hippocampal neurochemistry in healthy elderly. NeuroReport, 14(10), 1333-1337.

Conferences

  • Valenzuela, M. (2011). Cultivating a Cognitive Lifestyle. National Dementia Research Forum 2011, Sydney.
  • Valenzuela, M. (2011). Dogs, dermis and dementia: Regeneration and degeneration in man's best friend. Alzheimer's Australia 14th National Conference, Brisbane.
  • Valenzuela, M. (2011). Early Career Research Session - Grantsmanship. National Dementia Research Forum 2011, Sydney.
  • Valenzuela, M. (2011). Exercise for the mind and the body. National Dementia Research Forum 2011, Sydney.
  • Valenzuela, M. (2011). Neurogenesis in the Live Human Brain: Opportunities and Challenges for Psychiatry. First National Symposium On Translational Psychiatry.
  • Valenzuela, M. (2010). Cognitive Lifestyle and Brain Training. International Federation of Aging 2010, Melbourne.
  • Valenzuela, M. (2010). Detection of neurogenesis in psychiatric patients for response prediction. Neuroimaging as Endpoints in Clinical Trials Summer Workshop, Provence, France.
  • Valenzuela, M. (2009). Brain Training for the Prevention of dementia. Masterclass in Alzheimer's Disease, Sydney.
  • Valenzuela, M. (2009). Cognitive Lifestyle, Dogs, Dermis and Dementia Prevention. Columbia University College of Surgeons and Physicians seminar series.
  • Valenzuela, M. (2009). Reducing Dementia Risk: Cognitive lifestyle and brain training. International Federation of Aging 10th Global Conference of Aging, Melbourne.
  • Salvin, H., McGreevy, P., Valenzuela, M., Sachdev, P. (2009). The influence of breed on canine ageing. 43rd Congress of the International Society for Applied Ethology 2009, Australia: International Society for Applied Ethology.
  • Valenzuela, M. (2008). Can Cognitive Training Prevent Dementia. Alzheimer's Association International Conference on Alzheimer's Disease AAICAD 2009, United States: Alzheimers Association.
  • Valenzuela, M. (2008). Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy. Alzheimer's Association International Conference on Alzheimer's Disease AAICAD 2008, United States: Alzheimers Association.
  • Valenzuela, M. (2008). The SMART Trial: Study of Mental Activity & Regular Training for the prevention of cognitive decline in at-risk elderly. International College of Geriatric Psychoneuropharmacology, Sydney.
  • Valenzuela, M. (2008). Use it or Lose it - Preventing Cognitive Decline. Annual Scientific Meeting of the Australian and New Zealand College of Anaesthetists (ANZCA), Sydney: Australian and New Zealand College of Anaesthetists.

2016

  • Hallock, H., Collins, D., Lampit, A., Deol, K., Fleming, J., Valenzuela, M. (2016). Cognitive Training for Post-Acute Traumatic Brain Injury: A Meta-Analysis. Frontiers in Human Neuroscience, 10, Article 537. [More Information]
  • Hill, N., Mowszowski, L., Naismith, S., Chadwick, V., Valenzuela, M., Lampit, A. (2016). Computerized Cognitive Training In Older Adults With Mild Cognitive Impairment Or Dementia: A Systematic Review And Meta-Analysis. The American Journal of Psychiatry, Published ahead of print.
  • Mavros, Y., Gates, N., Wilson, G., Jain, N., Meiklejohn, J., Brodaty, H., Wen, W., Singh, N., Baune, B., Suo, C., Baker, M., Foroughi, N., Wang, Y., Valenzuela, M., Fiatarone Singh, M., et al (2016). Mediation of Cognitive Function Improvements by Strength Gains After Resistance Training in Older Adults with Mild Cognitive Impairment: Outcomes of the Study of Mental and Resistance Training. Journal of the American Geriatrics Society, 2016 (Article in press). [More Information]
  • Suo, C., Gates, N., Singh, M., Saigal, N., Wilson, G., Meiklejohn, J., Sachdev, P., Brodaty, H., Wen, W., Singh, N., Baker, M., Foroughi, N., Valenzuela, M., et al (2016). Midlife managerial experience is linked to late life hippocampal morphology and function. Brain Imaging and Behavior, Article in press. [More Information]
  • Truong, N., Si, E., Duncan, T., Valenzuela, M. (2016). Modeling neurodegenerative disorders in adult somatic cells: A critical review. Frontiers in Biology, 11(3), 232-245. [More Information]
  • Lampit, A., Duffy, S., Valenzuela, M. (2016). Physical exercise for brain health in later life: how does it work? In Linda C. W. Lam, Michelle Riba (Eds.), Physical Exercise Interventions for Mental Health, (pp. 147-163). Cambridge: Cambridge University Press.
  • Lavrencic, L., Kurylowicz, L., Valenzuela, M., Churches, O., Keage, H. (2016). Social cognition is not associated with cognitive reserve in older adults. Aging, Neuropsychology, and Cognition, 23(1), 61-77. [More Information]
  • Suo, C., Fiatarone Singh, M., Gates, N., Wen, W., Sachdev, P., Brodaty, H., Saigal, N., Wilson, G., Meiklejohn, J., Singh, N., Baker, M., Mavros, Y., Lampit, A., Leung, I., et al (2016). Therapeutically Relevant Structural and Functional Mechanisms Triggered by Physical and Cognitive Exercise. Molecular Psychiatry, 216, 1633-1642. [More Information]

2015

  • Leung, I., Walton, C., Hallock, H., Lewis, S., Valenzuela, M., Lampit, A. (2015). Cognitive training in Parkinson disease: A systematic review and meta-analysis. Neurology, 85(21), 1843-1851. [More Information]
  • Lampit, A., Hallock, H., Suo, C., Naismith, S., Valenzuela, M. (2015). Cognitive training-induced short-term functional and long-term structural plastic change is related to gains in global cognition in healthy older adults: a pilot study. Frontiers in Aging Neuroscience, 7, 1-13. [More Information]
  • Lampit, A., Valenzuela, M., Gates, N. (2015). Computerized Cognitive Training Is Beneficial for Older Adults. Journal of the American Geriatrics Society, 63(12), 2610-2612. [More Information]
  • Lowe, A., Dalton, M., Sidhu, K., Sachdev, P., Reynolds, B., Valenzuela, M. (2015). Neurogenesis and precursor cell differences in the dorsal and ventral adult canine hippocampus. Neuroscience Letters, 593, 107-113. [More Information]
  • Lampit, A., Valenzuela, M. (2015). Pointing the FINGER at multimodal dementia prevention. The Lancet, 386(10004), 1625-1626. [More Information]
  • Valenzuela, M., Turner, L., Kochan, N., Wen, W., Suo, C., Hallock, H., Mcintosh, R., Sachdev, P., Breakspear, M. (2015). Posterior compensatory network in cognitively intact elders with hippocampal atrophy. Hippocampus, 25(5), 581-593. [More Information]
  • Fiatarone Singh, M., Gates, N., Saigal, N., Wilson, G., Meiklejohn, J., Brodaty, H., Wen, W., Baker, M., Singh, N., Suo, C., et al (2015). Reply to the Letter to the Editor by O'Caoimh et al. Journal of the American Medical Directors Association (JAMDA), 16(11), 999-1001. [More Information]
  • Lampit, A., Valenzuela, M., Gates, N. (2015). Response to Dr. Edward Ratner et al. Journal of the American Geriatrics Society, 63(12), 2615-2615. [More Information]

2014

  • Carrasco, J., Georgevsky, D., Valenzuela, M., McGreevy, P. (2014). A pilot study of sexual dimorphism in the head morphology of domestic dogs. Journal of Veterinary Behavior, 9(1), 43-46. [More Information]
  • Stuart, K., Summers, M., Valenzuela, M., Vickers, J. (2014). BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults. Neurobiology of Learning and Memory, 110, 1-7. [More Information]
  • Bennett, D., Arnold, S., Valenzuela, M., Brayne, C., Schneider, J. (2014). Cognitive and social lifestyle: Links with neuropathology and cognition in late life. Acta Neuropathologica, 127(1), 137-150. [More Information]
  • Lampit, A., Hallock, H., Valenzuela, M. (2014). Computerized Cognitive Training in Cognitively Healthy Older Adults: A Systematic Review and Meta-Analysis of Effect Modifiers. PLoS Medicine, 11(11), 1-18. [More Information]
  • Georgevsky, D., Carrasco, J., Valenzuela, M., McGreevy, P. (2014). Domestic dog skull diversity across breeds , breed groupings and genetic clusters. Journal of Veterinary Behavior, 9(5), 228-234. [More Information]
  • Kolanowski, A., Hill, N., Kurum, E., Fick, D., Yevchak, A., Mulhall, P., Clare, L., Valenzuela, M. (2014). Gender Differences in Factors Associated With Delirium Severity in Older Adults With Dementia. Archives of Psychiatric Nursing, 28(3), 187-192. [More Information]
  • Hong, A., Suo, C., Valenzuela, M., Haydu, L., Jacobsen, K., Reisse, C., Fogarty, G. (2014). Low incidence of melanoma brain metastasis in the hippocampus. Radiotherapy and Oncology, 111(1), 59-62. [More Information]
  • Lampit, A., Ebster, C., Valenzuela, M. (2014). Multi-domain computerized cognitive training program improves performance of bookkeeping tasks: a matched-sampling active-controlled trial. Frontiers in Psychology, 5, 1-7. [More Information]
  • Gates, N., Valenzuela, M., Sachdev, P., Fiatarone Singh, M. (2014). Psychological well-being in individuals with mild cognitive impairment. Clinical Interventions in Aging, 9, 779-792. [More Information]
  • Fiatarone Singh, M., Gates, N., Saigal, N., Wilson, G., Meiklejohn, J., Brodaty, H., Wen, W., Singh, N., Baune, B., Suo, C., Baker, M., Foroughi, N., Valenzuela, M., et al (2014). The Study of Mental and Resistance Training (SMART) Study-Resistance Training and/or Cognitive Training in Mild Cognitive Impairment: A Randomized, Double-Blind, Double-Sham Controlled Trial. Journal of the American Medical Directors Association (JAMDA), 15(12), 873-880. [More Information]
  • Lampit, A., Hallock, H., Moss, R., Kwok, S., Rosser, M., Lukjanenko, M., Kohn, A., Naismith, S., Brodaty, H., Valenzuela, M. (2014). The Timecourse of Global Cognitive Gains from Supervised Computer-Assisted Cognitive Training: A Randomised, Active-Controlled Trial in Elderly with Multiple Dementia Risk Factors. The Journal of Prevention of Alzheimer's Disease, 1(1), 33-39.

2013

  • Siette, J., Westbrook, R., Cotman, C., Sidhu, K., Zhu, W., Sachdev, P., Valenzuela, M. (2013). Age-Specific Effects of Voluntary Exercise on Memory and the Older Brain. Biological Psychiatry, 73(5), 435-442. [More Information]
  • Valenzuela, M., Leon, I., Suo, C., Martinez Piamba, D., Kochan, N., Brodaty, H., Sachdev, P. (2013). Cognitive Lifestyle in Older Persons: The Population-Based Sydney Memory & Ageing Study. Journal of Alzheimer's Disease, 36(1), 87-97. [More Information]
  • McGreevy, P., Georgevsky, D., Carrasco, J., Valenzuela, M., Duffy, D., Serpell, J. (2013). Dog Behavior Co-Varies with Height, Bodyweight and Skull Shape. PloS One, 8(12), 1-7. [More Information]
  • Valenzuela, M., Bartres-Faz, D., Bullmore, E., Fjell, A., Maletic-Savetic, M., Martins, R., Solowij, N., Yucel, M. (2013). More thinking about less data: a perspective from the 2nd Provence Summer Workshop. Molecular Psychiatry, 18(5), 524-525. [More Information]
  • Borness, C., Proudfoot, J., Crawford, J., Valenzuela, M. (2013). Putting Brain Training to the Test in the Workplace: A Randomized, Blinded, Multisite, Active-Controlled Trial. PloS One, 8(3), 1-8. [More Information]
  • Gates, N., Fiatarone Singh, M., Sachdev, P., Valenzuela, M. (2013). The Effect of Exercise Training on Cognitive Function in Older Adults with Mild Cognitive Impairment: A Meta-analysis of Randomized Controlled Trials. American Journal of Geriatric Psychiatry, 21(11), 1086-1097. [More Information]
  • Summers, M., Saunders, N., Valenzuela, M., Summers, J., Ritchie, K., Robinson, A., Vickers, J. (2013). The Tasmanian Healthy Brain Project (THBP): a prospective longitudinal examination of the effect of university-level education in older adults in preventing age-related cognitive decline and reducing the risk of dementia. International Psychogeriatrics, 25(7), 1145-1155. [More Information]

2012

  • Marioni, R., van den Hout, A., Valenzuela, M., Brayne, C., Matthews, F. (2012). Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline. Journal of Alzheimer's Disease, 28(1), 223-230. [More Information]
  • Marioni, R., Valenzuela, M., van den Hout, A., Brayne, C., Matthews, F. (2012). Active cognitive lifestyle is associated with positive cognitive health transitions and compression of morbidity from age sixty-five. PloS One, 7(12), 1-6. [More Information]
  • Valenzuela, M., Esler, M., Ritchie, K., Brodaty, H. (2012). Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention. Translational Psychiatry, 2, 1-10. [More Information]
  • Valenzuela, M. (2012). Brain and heart targets for better dementia prevention. Medicine Today, 13(2), 38-43.
  • Salvin, H., MaGrath, C., McGreevy, P., Valenzuela, M. (2012). Development of a novel paradigm for the measurement of olfactory discrimination in dogs (Canis familiaris): A pilot study. Journal of Veterinary Behavior, 7(1), 3-10. [More Information]
  • Borness, C., Proudfoot, J., Valenzuela, M. (2012). Methodological Challenges and Solutions When Conducting a Multicenter, Online, Randomized Controlled Trial of Brain Training Within a Public Service Organization. Journal of Workplace Behavioral Health, 27(4), 272-288. [More Information]
  • Valenzuela, M., Matthews, F., Brayne, C., Ince, P., Halliday, G., Kril, J., Dalton, M., Richardson, K., Forster, G., Sachdev, P. (2012). Multiple Biological Pathways Link Cognitive Lifestyle to Protection from Dementia. Biological Psychiatry, 71(9), 783-791. [More Information]
  • Suo, C., Valenzuela, M. (2012). Neuroimaging Outcomes of Brain Training Trials. In Prof. Peter Bright (Eds.), Neuroimaging - Cognitive and Clinical Neuroscience, (pp. 417-430). Rijeka, Croatia: Intech.
  • Suo, C., Leon, I., Brodaty, H., Troller, J., Wen, W., Sachdev, P., Valenzuela, M. (2012). Supervisory experience at work is linked to low rate of hippocampal atrophy in late life. NeuroImage, 63(3), 1542-1551. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2012). The effect of breed on age-related changes in behavior and disease prevalence in cognitively normal older community dogs, canis lupus familiaris. Journal of Veterinary Behavior, 7(2), 61-69. [More Information]

2011

  • Gates, N., Sachdev, P., Fiatarone Singh, M., Valenzuela, M. (2011). Cognitive and memory training in adults at risk of dementia: A Systematic Review. BMC Geriatrics, 11, 1-14. [More Information]
  • Valenzuela, M., Brayne, C., Sachdev, P., Wilcock, G., Matthews, F. (2011). Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort. American Journal of Epidemiology, 173(9), 1004-1012. [More Information]
  • Kochan, N., Breakspear, M., Valenzuela, M., Slavin, M., Brodaty, H., Wen, W., Trollor, J., Turner, A., Crawford, J., Sachdev, P. (2011). Cortical responses to a graded working memory challenge predict functional decline in mild cognitive impairment. Biological Psychiatry, 70(2), 123-130. [More Information]
  • Valenzuela, M. (2011). Cultivating a Cognitive Lifestyle. National Dementia Research Forum 2011, Sydney.
  • Valenzuela, M. (2011). Dogs, dermis and dementia: Regeneration and degeneration in man's best friend. Alzheimer's Australia 14th National Conference, Brisbane.
  • Valenzuela, M. (2011). Early Career Research Session - Grantsmanship. National Dementia Research Forum 2011, Sydney.
  • Valenzuela, M. (2011). Exercise for the mind and the body. National Dementia Research Forum 2011, Sydney.
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2011). Growing old gracefully - Behavioral changes associated with "successful aging" in the dog, Canis familaris. Journal of Veterinary Behavior, 6(6), 313-320. [More Information]
  • Kochan, N., Valenzuela, M., Slavin, M., McCraw, S., Sachdev, P., Breakspear, M. (2011). Impact of load-related neural processes on feature binding in visuospatial working memory. PloS One, 6(8), 1-14. [More Information]
  • Valenzuela, M. (2011). Maintain Your Brain: What you can do to improve your brains health and avoid dementia. Sydney, Australia: ABC Books.
  • Song, F., Poljak, A., Valenzuela, M., Mayeux, R., Smythe, G., Sachdev, P. (2011). Meta-analysis of plasma amyloid-beta levels in alzheimer's disease. Journal of Alzheimer's Disease, 26(2), 365-375. [More Information]
  • Valenzuela, M. (2011). Neurogenesis in the Live Human Brain: Opportunities and Challenges for Psychiatry. First National Symposium On Translational Psychiatry.
  • Gates, N., Valenzuela, M., Sachdev, P., Singh, N., Baune, B., Brodaty, H., Suo, C., Jain, N., Wilson, G., Wang, Y., Baker, M., Williamson, D., Foroughi, N., Fiatarone Singh, M. (2011). Study of Mental Activity and Regular Training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial. BMC Geriatrics, 11(19), 1-15. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2011). The canine cognitive dysfunction rating scale (CCDR): A data-driven and ecologically relevant assessment tool. The Veterinary Journal, 188(3), 331-336. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2011). The Canine Sand Maze: An Appetitive Spatial Memory Paradigm Sensitive To Age-Related Changes in Dog. Journal of the Experimental Analysis of Behavior, 95(1), 109-118. [More Information]
  • Valenzuela, M. (2011). The Changing Brain. In Helen Sykes (Eds.), HEALTH, (pp. 174-185). Melbourne: Future Leaders.

2010

  • Gates, N., Valenzuela, M. (2010). Cognitive exercise and its role in cognitive function in older adults. Current Psychiatry Reports, 12(1), 20-27. [More Information]
  • Valenzuela, M. (2010). Cognitive Lifestyle and Brain Training. International Federation of Aging 2010, Melbourne.
  • Valenzuela, M. (2010). Detection of neurogenesis in psychiatric patients for response prediction. Neuroimaging as Endpoints in Clinical Trials Summer Workshop, Provence, France.
  • Kochan, N., Breakspear, M., Slavin, M., Valenzuela, M., McCraw, S., Brodaty, H., Sachdev, P. (2010). Functional alterations in brain activation and deactivation in mild cognitive impairment in response to a graded working memory challenge. Dementia and Geriatric Cognitive Disorders, 30(6), 553-568. [More Information]
  • Roberts, T., McGreevy, P., Valenzuela, M. (2010). Human Induced Rotation and Reorganization of the Brain of Domestic Dogs. PloS One, 5(7), 1-7. [More Information]
  • Salvin, H., McGreevy, P., Sachdev, P., Valenzuela, M. (2010). Under diagnosis of canine cognitive dysfunction: A cross-sectional survey of older companion dogs. The Veterinary Journal, 184, 277-281. [More Information]

2009

  • Valenzuela, M. (2009). Brain Training for the Prevention of dementia. Masterclass in Alzheimer's Disease, Sydney.
  • Valenzuela, M. (2009). Cognitive Lifestyle, Dogs, Dermis and Dementia Prevention. Columbia University College of Surgeons and Physicians seminar series.
  • Valenzuela, M. (2009). Its Never Too Late to Change Your Mind: The Latest Medical Thinking on What You Can Do to Avoid Dementia. Sydney: ABC Books.
  • Valenzuela, M. (2009). Reducing Dementia Risk: Cognitive lifestyle and brain training. International Federation of Aging 10th Global Conference of Aging, Melbourne.
  • Salvin, H., McGreevy, P., Valenzuela, M., Sachdev, P. (2009). The influence of breed on canine ageing. 43rd Congress of the International Society for Applied Ethology 2009, Australia: International Society for Applied Ethology.

2008

  • Valenzuela, M. (2008). Can Cognitive Training Prevent Dementia. Alzheimer's Association International Conference on Alzheimer's Disease AAICAD 2009, United States: Alzheimers Association.
  • Valenzuela, M., Sachdev, P., Wen, W., Chen, X., Brodaty, H. (2008). Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy. PloS One, 3(7), 1-6. [More Information]
  • Valenzuela, M. (2008). Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy. Alzheimer's Association International Conference on Alzheimer's Disease AAICAD 2008, United States: Alzheimers Association.
  • Valenzuela, M. (2008). The SMART Trial: Study of Mental Activity & Regular Training for the prevention of cognitive decline in at-risk elderly. International College of Geriatric Psychoneuropharmacology, Sydney.
  • Valenzuela, M. (2008). Use it or Lose it - Preventing Cognitive Decline. Annual Scientific Meeting of the Australian and New Zealand College of Anaesthetists (ANZCA), Sydney: Australian and New Zealand College of Anaesthetists.

2005

  • Brodaty, H., Sachdev, P., Withall, A., Altendorf, A., Valenzuela, M., Lorentz, L. (2005). Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke -the Sydney Stroke Study. Psychological Medicine, 35(12), 1707-1716.

2003

  • Valenzuela, M., Jones, M., Wen, W., Rae, C., Graham, S., Shnier, R., Sachdev, P. (2003). Memory training alters hippocampal neurochemistry in healthy elderly. NeuroReport, 14(10), 1333-1337.

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