Associate Professor Mika Jormakka

Associate Professor
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6280
Fax +61 2 9565 6101

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Selected grants

2014

  • Mechanism of bacterial iron uptake; Jormakka M; DVC Research/Bridging Support Grant.

2013

  • Structural studies of membrane proteins; Jormakka M; DVC Research/Bridging Support Grant.
  • Multiangle laser light scattering instrument for protein characterisation; Mackay J, Ataide S, Jormakka M, Ryan R, Matthews J, Shepherd N, Sunde M, Collyer C, Payne R; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • A targeted nutrient-depletion approach to tackle prostate cancer; Jormakka M; National Health and Medical Research Council (NHMRC)/Career Development Fellowship.

2011

  • Structural analysysis of amino acid transporters that regulate the mTOR pathway; Jormakka M, Bailey C, Holst J; Prostate Cancer Foundation of Australia/Project Grants.
  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Federated Single Crystal X-ray Structural Analysis Facility; Kepert C, Guss M, Malby R, Jormakka M, Cole M, Dixon N, Kearley G; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The molecular basis of G protein coupled transport; Jormakka M, Maher M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Molecular basis of Fluoroquinolone resistance; Jormakka M; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • A rational approach to a high-resolution structure of the multidrug transporter EmrE; Jormakka M, Curmi P, Rapp M, von Heijne G; Australian Research Council (ARC)/International Researcher Exchange Programme (IREX).

2007

  • Development of novel drugs for the inhibition of prostate cancer metastasis: Relationship to drug-induced expression of the tumour metastasis suppressor, Drg-1; Jormakka M, Rapp M, Richardson D, Curmi P, Von Heijne G; Australian Research Council (ARC)/Linkage International: ARC International Fellowships (ARCIF).
  • Structural determination of respiratory membrane protein complexes by X-ray crystallography; Jormakka M; Australian Research Council (ARC)/Discovery Projects (DP).

Selected publications

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Journals

  • Deshpande, C., McGrath, A., Font, J., Guilfoyle, A., Maher, M., Jormakka, M. (2013). Structure of an atypical FeoB G-domain reveals a putative domain-swapped dimer. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, F69(4), 399-404. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2012). The cation-dependent G-proteins: In a class of their own. FEBS Letters, 586(16), 2218-2224. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB. Acta Crystallographica. Section D: Biological Crystallography, 67(11), 973-980. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). The initiation of GTP hydrolysis by the g-domain of FeoB: Insights from a transition-state complex structure. PLoS One, 6(8), 1-10. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). The structure of an N11A mutant of the G-protein domain of FeoB. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67(12), 1511-1515. [More Information]
  • Chiu, C., Bagnall, R., Ingles, J., Yeates, L., Kennerson, M., Donald, J., Jormakka, M., Lind, J., Semsarian, C. (2010). Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy: A Genome-Wide Analysis. Journal of the American College of Cardiology, 55(11), 1127-1135. [More Information]
  • Ash, M., Guilfoyle, A., Clarke, R., Guss, M., Maher, M., Jormakka, M. (2010). Potassium-activated GTPase reaction in the G protein-coupled ferrous iron transporter B. Journal of Biological Chemistry, 285(19), 14594-14602. [More Information]
  • Guilfoyle, A., Maher, M., Rapp, M., Clarke, R., Harrop, S., Jormakka, M. (2009). Structural basis of GDP release and gating in G protein coupled Fe(2+) transport. The EMBO Journal, 28(17), 2677-2685. [More Information]
  • Jormakka, M., Yokoyama, K., Yano, T., Tamakoshi, M., Akimoto, S., Shimamura, T., Curmi, P., Iwata, S. (2008). Molecular mechanism of energy conservation in polysulfide respiration. Nature Structural and Molecular Biology, 15(7), 730-737. [More Information]
  • Jormakka, M., Richardson, D., Byrne, B., Iwata, S. (2004). Architecture of NarGH Reveals a Structural Classification of Mo-bisMGD Enzymes. Structure, 12(1), 95-104.
  • Jormakka, M., Byrne, B., Iwata, S. (2003). Formate dehydrogenase - A versatile enzyme in changing environments. Current Opinion in Structural Biology, 13(4), 418-423.
  • Jormakka, M., Byrne, B., Iwata, S. (2003). Protonmotive force generation by a redox loop mechanism. FEBS Letters, 545(1), 25-30.
  • Clerk, A., Cole, S., Cullingford, T., Harrison, J., Jormakka, M., Valks, D. (2003). Regulation of cardiac myocyte cell death. Pharmacology and Therapeutics, 97(3), 223-261.

2013

  • Deshpande, C., McGrath, A., Font, J., Guilfoyle, A., Maher, M., Jormakka, M. (2013). Structure of an atypical FeoB G-domain reveals a putative domain-swapped dimer. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, F69(4), 399-404. [More Information]

2012

  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2012). The cation-dependent G-proteins: In a class of their own. FEBS Letters, 586(16), 2218-2224. [More Information]

2011

  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB. Acta Crystallographica. Section D: Biological Crystallography, 67(11), 973-980. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). The initiation of GTP hydrolysis by the g-domain of FeoB: Insights from a transition-state complex structure. PLoS One, 6(8), 1-10. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). The structure of an N11A mutant of the G-protein domain of FeoB. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67(12), 1511-1515. [More Information]

2010

  • Chiu, C., Bagnall, R., Ingles, J., Yeates, L., Kennerson, M., Donald, J., Jormakka, M., Lind, J., Semsarian, C. (2010). Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy: A Genome-Wide Analysis. Journal of the American College of Cardiology, 55(11), 1127-1135. [More Information]
  • Ash, M., Guilfoyle, A., Clarke, R., Guss, M., Maher, M., Jormakka, M. (2010). Potassium-activated GTPase reaction in the G protein-coupled ferrous iron transporter B. Journal of Biological Chemistry, 285(19), 14594-14602. [More Information]

2009

  • Guilfoyle, A., Maher, M., Rapp, M., Clarke, R., Harrop, S., Jormakka, M. (2009). Structural basis of GDP release and gating in G protein coupled Fe(2+) transport. The EMBO Journal, 28(17), 2677-2685. [More Information]

2008

  • Jormakka, M., Yokoyama, K., Yano, T., Tamakoshi, M., Akimoto, S., Shimamura, T., Curmi, P., Iwata, S. (2008). Molecular mechanism of energy conservation in polysulfide respiration. Nature Structural and Molecular Biology, 15(7), 730-737. [More Information]

2004

  • Jormakka, M., Richardson, D., Byrne, B., Iwata, S. (2004). Architecture of NarGH Reveals a Structural Classification of Mo-bisMGD Enzymes. Structure, 12(1), 95-104.

2003

  • Jormakka, M., Byrne, B., Iwata, S. (2003). Formate dehydrogenase - A versatile enzyme in changing environments. Current Opinion in Structural Biology, 13(4), 418-423.
  • Jormakka, M., Byrne, B., Iwata, S. (2003). Protonmotive force generation by a redox loop mechanism. FEBS Letters, 545(1), 25-30.
  • Clerk, A., Cole, S., Cullingford, T., Harrison, J., Jormakka, M., Valks, D. (2003). Regulation of cardiac myocyte cell death. Pharmacology and Therapeutics, 97(3), 223-261.

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