Associate Professor Mika Jormakka

Associate Professor
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6280
Fax +61 2 9565 6101

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Selected grants

2015

  • Mechanism of anoxic iron acquisition in pathogenic bacteria; Jormakka M, Maher M, Ryan R; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Mechanism of bacterial iron uptake; Jormakka M; DVC Research/Bridging Support Grant.

2013

  • Structural studies of membrane proteins; Jormakka M; DVC Research/Bridging Support Grant.
  • Multiangle laser light scattering instrument for protein characterisation; Mackay J, Ataide S, Jormakka M, Ryan R, Matthews J, Shepherd N, Sunde M, Collyer C, Payne R; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • A targeted nutrient-depletion approach to tackle prostate cancer; Jormakka M; National Health and Medical Research Council (NHMRC)/Career Development Fellowship.

2011

  • Structural analysysis of amino acid transporters that regulate the mTOR pathway; Jormakka M, Bailey C, Holst J; Prostate Cancer Foundation of Australia/Project Grants.
  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Federated Single Crystal X-ray Structural Analysis Facility; Kepert C, Guss M, Malby R, Jormakka M, Cole M, Dixon N, Kearley G; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The molecular basis of G protein coupled transport; Jormakka M, Maher M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Molecular basis of Fluoroquinolone resistance; Jormakka M; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • A rational approach to a high-resolution structure of the multidrug transporter EmrE; Jormakka M, Curmi P, Rapp M, von Heijne G; Australian Research Council (ARC)/International Researcher Exchange Programme (IREX).

2007

  • Development of novel drugs for the inhibition of prostate cancer metastasis: Relationship to drug-induced expression of the tumour metastasis suppressor, Drg-1; Jormakka M, Rapp M, Richardson D, Curmi P, Von Heijne G; Australian Research Council (ARC)/Linkage International: ARC International Fellowships (ARCIF).
  • Structural determination of respiratory membrane protein complexes by X-ray crystallography; Jormakka M; Australian Research Council (ARC)/Discovery Projects (DP).

Selected publications

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Journals

  • Wang, K., Grkovic, T., Font Sadurni, J., Bonham, S., Pouwer, R., Bailey, C., Moran, A., Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al (2014). Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growt. ACS Chemical Biology, 9(6), 1369-1376. [More Information]
  • Wang, K., Beaumont, K., Otte, N., Font Sadurni, J., Bailey, C., van Geldermalsen, M., Sharp, D., Tiffen, J., Ryan, R., Jormakka, M., Haass, N., Rasko, J., Holst, J. (2014). Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer, 135(5), 1060-1071. [More Information]
  • Deshpande, C., McGrath, A., Font, J., Guilfoyle, A., Maher, M., Jormakka, M. (2013). Structure of an atypical FeoB G-domain reveals a putative domain-swapped dimer. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, F69(4), 399-404. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2012). The cation-dependent G-proteins: In a class of their own. FEBS Letters, 586(16), 2218-2224. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB. Acta Crystallographica. Section D: Biological Crystallography, 67(11), 973-980. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). The initiation of GTP hydrolysis by the g-domain of FeoB: Insights from a transition-state complex structure. PLoS One, 6(8), 1-10. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). The structure of an N11A mutant of the G-protein domain of FeoB. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67(12), 1511-1515. [More Information]
  • Chiu, C., Bagnall, R., Ingles, J., Yeates, L., Kennerson, M., Donald, J., Jormakka, M., Lind, J., Semsarian, C. (2010). Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy: A Genome-Wide Analysis. Journal of the American College of Cardiology, 55(11), 1127-1135. [More Information]
  • Ash, M., Guilfoyle, A., Clarke, R., Guss, M., Maher, M., Jormakka, M. (2010). Potassium-activated GTPase reaction in the G protein-coupled ferrous iron transporter B. Journal of Biological Chemistry, 285(19), 14594-14602. [More Information]
  • Guilfoyle, A., Maher, M., Rapp, M., Clarke, R., Harrop, S., Jormakka, M. (2009). Structural basis of GDP release and gating in G protein coupled Fe(2+) transport. The EMBO Journal, 28(17), 2677-2685. [More Information]
  • Jormakka, M., Yokoyama, K., Yano, T., Tamakoshi, M., Akimoto, S., Shimamura, T., Curmi, P., Iwata, S. (2008). Molecular mechanism of energy conservation in polysulfide respiration. Nature Structural and Molecular Biology, 15(7), 730-737. [More Information]
  • Jormakka, M., Richardson, D., Byrne, B., Iwata, S. (2004). Architecture of NarGH Reveals a Structural Classification of Mo-bisMGD Enzymes. Structure, 12(1), 95-104.
  • Jormakka, M., Byrne, B., Iwata, S. (2003). Formate dehydrogenase - A versatile enzyme in changing environments. Current Opinion in Structural Biology, 13(4), 418-423.
  • Jormakka, M., Byrne, B., Iwata, S. (2003). Protonmotive force generation by a redox loop mechanism. FEBS Letters, 545(1), 25-30.
  • Clerk, A., Cole, S., Cullingford, T., Harrison, J., Jormakka, M., Valks, D. (2003). Regulation of cardiac myocyte cell death. Pharmacology and Therapeutics, 97(3), 223-261.

2014

  • Wang, K., Grkovic, T., Font Sadurni, J., Bonham, S., Pouwer, R., Bailey, C., Moran, A., Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al (2014). Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growt. ACS Chemical Biology, 9(6), 1369-1376. [More Information]
  • Wang, K., Beaumont, K., Otte, N., Font Sadurni, J., Bailey, C., van Geldermalsen, M., Sharp, D., Tiffen, J., Ryan, R., Jormakka, M., Haass, N., Rasko, J., Holst, J. (2014). Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer, 135(5), 1060-1071. [More Information]

2013

  • Deshpande, C., McGrath, A., Font, J., Guilfoyle, A., Maher, M., Jormakka, M. (2013). Structure of an atypical FeoB G-domain reveals a putative domain-swapped dimer. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, F69(4), 399-404. [More Information]

2012

  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2012). The cation-dependent G-proteins: In a class of their own. FEBS Letters, 586(16), 2218-2224. [More Information]

2011

  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB. Acta Crystallographica. Section D: Biological Crystallography, 67(11), 973-980. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). The initiation of GTP hydrolysis by the g-domain of FeoB: Insights from a transition-state complex structure. PLoS One, 6(8), 1-10. [More Information]
  • Ash, M., Maher, M., Guss, M., Jormakka, M. (2011). The structure of an N11A mutant of the G-protein domain of FeoB. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67(12), 1511-1515. [More Information]

2010

  • Chiu, C., Bagnall, R., Ingles, J., Yeates, L., Kennerson, M., Donald, J., Jormakka, M., Lind, J., Semsarian, C. (2010). Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy: A Genome-Wide Analysis. Journal of the American College of Cardiology, 55(11), 1127-1135. [More Information]
  • Ash, M., Guilfoyle, A., Clarke, R., Guss, M., Maher, M., Jormakka, M. (2010). Potassium-activated GTPase reaction in the G protein-coupled ferrous iron transporter B. Journal of Biological Chemistry, 285(19), 14594-14602. [More Information]

2009

  • Guilfoyle, A., Maher, M., Rapp, M., Clarke, R., Harrop, S., Jormakka, M. (2009). Structural basis of GDP release and gating in G protein coupled Fe(2+) transport. The EMBO Journal, 28(17), 2677-2685. [More Information]

2008

  • Jormakka, M., Yokoyama, K., Yano, T., Tamakoshi, M., Akimoto, S., Shimamura, T., Curmi, P., Iwata, S. (2008). Molecular mechanism of energy conservation in polysulfide respiration. Nature Structural and Molecular Biology, 15(7), 730-737. [More Information]

2004

  • Jormakka, M., Richardson, D., Byrne, B., Iwata, S. (2004). Architecture of NarGH Reveals a Structural Classification of Mo-bisMGD Enzymes. Structure, 12(1), 95-104.

2003

  • Jormakka, M., Byrne, B., Iwata, S. (2003). Formate dehydrogenase - A versatile enzyme in changing environments. Current Opinion in Structural Biology, 13(4), 418-423.
  • Jormakka, M., Byrne, B., Iwata, S. (2003). Protonmotive force generation by a redox loop mechanism. FEBS Letters, 545(1), 25-30.
  • Clerk, A., Cole, S., Cullingford, T., Harrison, J., Jormakka, M., Valks, D. (2003). Regulation of cardiac myocyte cell death. Pharmacology and Therapeutics, 97(3), 223-261.

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