Dr Margaret Smith

Honorary Associate
Senior Research Fellow (NSW Health)
Institute for Bone & Joint Research, Northern Clinical School

Telephone +61 2 9926 4807
Fax 61 2 9926 5266

Map

International links

United Kingdom

(Cardiff University) Prof Bruce Caterson

Selected grants

2013

  • The diabetic hand - understanding the mechanisms of tendinopathy; Smith M, Little C; Lincoln Centre for Research into Bone & Joint Diseases/Research Support.

2010

  • Cellular mechanisms in chondroid degeneration of tendon; Little C, Sonnabend D, Smith M; Australian Orthopaedic Association Research Foundation Ltd/Research Support.

2009

  • Stem Cell treatment for tendon degeneration; Smith M, Little C, Smith M, Sonnabend D, Appleyard R, Melrose J, Hunyor S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Smith, M., Little, C. (2007). Experimental Models of Osteoarthritis. In Moskowitz, Altman, Hochberg, Buckwalter & Glodberg (Eds.), Osteoarthritis: Diagnosis and Medical/ Surgical Management, (pp. 107-125). Philadelphia, USA: Lippincott Williams & Wilkins.
  • Smith, M. (2005). Preclinical Studies on the Pharmacology of Hyaluronan in Relation to its Application as an Intra-Articular Therapy for the Treatment of Osteoarthritis. In E.A. Balazs and V.C. Hascall (Eds.), Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications, (pp. 491-502). New Jersey: Matrix Biology Inst.

Journals

  • Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 are activated by Activated Protein C (APC) in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatism, 66(6), 1525-1536. [More Information]
  • Smith, M., Russell, A., Schiavinato, A., Little, C. (2013). A hexadecylamide derivative of hyaluronan (HYMOVIS(R)) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. Journal of Inflammation, 10(1), 1-16. [More Information]
  • Melrose, J., Smith, M., Smith, S., Ravi, V., Young, A., Dart, A., Sonnabend, D., Little, C. (2013). Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy. Tissue and Cell, 45(1), 77-82. [More Information]
  • Cake, M., Read, R., Corfield, G., Daniel, A., Burkhardt, D., Smith, M., Little, C. (2013). Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Osteoarthritis and Cartilage, 21(1), 226-236. [More Information]
  • Smith, M., Ravi, V., Dart, A., Sonnabend, D., Little, C. (2013). Factors affecting tendinopathogenesis. British Journal of Sports Medicine, 47(9), 23-24. [More Information]
  • Smith, M., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47, 29-29.
  • Smith, M., Jacobson, E., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47(9), e2. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • Shu, C., Hughes, C., Smith, S., Smith, M., Hayes, A., Caterson, B., Little, C., Melrose, J. (2013). The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal, 30(7), 717-725. [More Information]
  • Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012). Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine, 37(1), 18-25. [More Information]
  • Fuller, E., Smith, M., Little, C., Melrose, J. (2012). Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthritis and Cartilage, 20(1), 49-59. [More Information]
  • Hayes, A., Lord, M., Smith, S., Smith, M., Whitelock, J., Weiss, A., Melrose, J. (2011). Colocalization in vivo and association in vitro of perlecan and elastin. Histochemistry and Cell Biology, 136, 437-454. [More Information]
  • Young, A., Smith, M., Bacle, G., Moraga, C., Walch, G. (2011). Early results of reverse shoulder arthroplasty in patients with rheumatoid arthritis. Journal of Bone and Joint Surgery: American Volume, 93(20), 1915-1923. [More Information]
  • Chan, B., Fuller, E., Russell, A., Smith, S., Smith, M., Jackson, M., Cake, M., Read, R., Bateman, J., Sambrook, P., Little, C. (2011). Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis and Cartilage, 19(7), 874-885. [More Information]
  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research & Therapy, 12(1), 1-13. [More Information]
  • Little, C., Smith, M., Cake, M., Read, R., Murphy, M., Barry, F. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis and Cartilage, 18(Suppl 3), S80-S92. [More Information]
  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis and Rheumatism, 60(3), 780-791. [More Information]
  • Smith, M., Klinger, H., Koelling, S., Baums, M., Kahl, E., Steckel, H., Schultz, W., Miosge, N. (2009). Cell biological and biomechanical evaluation of two different fixation techniques for rotator cuff repair. Scandinavian Journal Of Medicine and Science In Sports, 19(3), 329-337. [More Information]
  • Little, C., Smith, M. (2008). Animal Models of Osteoarthritis. Current Rheumatology Reviews, 4(3), 175-182. [More Information]
  • Cake, M., Read, R., Edwards, S., Smith, M., Burkhardt, D., Little, C., Ghosh, P. (2008). Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. Journal of orthopaedic science, 13(6), 514-523. [More Information]
  • Melrose, J., Fuller, E., Roughley, P., Smith, M., Kerr, B., Hughes, C., Caterson, B., Little, C. (2008). Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Research & Therapy, 10(doi:10.1186/ar2453), 1-10. [More Information]
  • Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gilles, R., Dart, A., Sonnabend, D., Little, C. (2008). Modulation of Aggrecan and ADAMTS Expression in Ovine Tendinopathy Induced by Altered Strain. Seminars in Arthritis and Rheumatism, 58(4), 1055-1066. [More Information]
  • Smith, M., Cake, M., Ghosh, P., Schiavinato, A., Read, R., Little, C. (2008). Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Print Edition), 47(8), 1172-1178. [More Information]
  • Cake, M., Smith, M., Young, A., Smith, S., Ghosh, P., Read, R. (2008). Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan). Clinical and Experimental Rheumatology, 26(4), 561-567. [More Information]
  • Melrose, J., Smith, S., Smith, M., Little, C. (2008). The use of Histochoice (tmR) for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotechnic and Histochemistry, 83(1), 47-53. [More Information]
  • Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. (2007). Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical Orthopaedics and Related Research, 462, 212-220. [More Information]
  • Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research & Therapy, 8(2), 1-6. [More Information]
  • Cake, M., Appleyard, R., Read, R., Ghosh, P., Murrell, G., Smith, M. (2005). Ovariectomy alters the structural and biomechanical properties of ovine femoro-tibial articular cartilage and increases cartilage iNOS. Osteoarthritis and Cartilage, 13(12), 1066-1075. [More Information]
  • Ghosh, P., Smith, M. (2002). Osteoarthritis, genetic and molecular mechanisms. Biogerontology, 3(1-2), 85-88.

Conferences

  • Jacobson, E., Smith, M., Mondori, T., Smith, S., Dart, A., Little, C. (2008). Focal injury induces widespread pathology in equine superficial digital flexor tendons. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
  • Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Spacio-temporal changes in pathology and proteoglycan gene expression in shoulder tendons induced by overstress or stress deprivation. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
  • Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Temporal change in proteoglycan gene expression and histopathology induced in sheep shoulder tendons by altered stress in vivo. Osteoarthritis Research Society International World Congress on Osteoarthritis OARSI 2008, United States: Osteoarthritis Research Society International.

2014

  • Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 are activated by Activated Protein C (APC) in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatism, 66(6), 1525-1536. [More Information]

2013

  • Smith, M., Russell, A., Schiavinato, A., Little, C. (2013). A hexadecylamide derivative of hyaluronan (HYMOVIS(R)) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. Journal of Inflammation, 10(1), 1-16. [More Information]
  • Melrose, J., Smith, M., Smith, S., Ravi, V., Young, A., Dart, A., Sonnabend, D., Little, C. (2013). Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy. Tissue and Cell, 45(1), 77-82. [More Information]
  • Cake, M., Read, R., Corfield, G., Daniel, A., Burkhardt, D., Smith, M., Little, C. (2013). Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Osteoarthritis and Cartilage, 21(1), 226-236. [More Information]
  • Smith, M., Ravi, V., Dart, A., Sonnabend, D., Little, C. (2013). Factors affecting tendinopathogenesis. British Journal of Sports Medicine, 47(9), 23-24. [More Information]
  • Smith, M., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47, 29-29.
  • Smith, M., Jacobson, E., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47(9), e2. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • Shu, C., Hughes, C., Smith, S., Smith, M., Hayes, A., Caterson, B., Little, C., Melrose, J. (2013). The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal, 30(7), 717-725. [More Information]

2012

  • Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012). Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine, 37(1), 18-25. [More Information]
  • Fuller, E., Smith, M., Little, C., Melrose, J. (2012). Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthritis and Cartilage, 20(1), 49-59. [More Information]

2011

  • Hayes, A., Lord, M., Smith, S., Smith, M., Whitelock, J., Weiss, A., Melrose, J. (2011). Colocalization in vivo and association in vitro of perlecan and elastin. Histochemistry and Cell Biology, 136, 437-454. [More Information]
  • Young, A., Smith, M., Bacle, G., Moraga, C., Walch, G. (2011). Early results of reverse shoulder arthroplasty in patients with rheumatoid arthritis. Journal of Bone and Joint Surgery: American Volume, 93(20), 1915-1923. [More Information]
  • Chan, B., Fuller, E., Russell, A., Smith, S., Smith, M., Jackson, M., Cake, M., Read, R., Bateman, J., Sambrook, P., Little, C. (2011). Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis and Cartilage, 19(7), 874-885. [More Information]

2010

  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research & Therapy, 12(1), 1-13. [More Information]
  • Little, C., Smith, M., Cake, M., Read, R., Murphy, M., Barry, F. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis and Cartilage, 18(Suppl 3), S80-S92. [More Information]

2009

  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis and Rheumatism, 60(3), 780-791. [More Information]
  • Smith, M., Klinger, H., Koelling, S., Baums, M., Kahl, E., Steckel, H., Schultz, W., Miosge, N. (2009). Cell biological and biomechanical evaluation of two different fixation techniques for rotator cuff repair. Scandinavian Journal Of Medicine and Science In Sports, 19(3), 329-337. [More Information]

2008

  • Little, C., Smith, M. (2008). Animal Models of Osteoarthritis. Current Rheumatology Reviews, 4(3), 175-182. [More Information]
  • Cake, M., Read, R., Edwards, S., Smith, M., Burkhardt, D., Little, C., Ghosh, P. (2008). Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. Journal of orthopaedic science, 13(6), 514-523. [More Information]
  • Jacobson, E., Smith, M., Mondori, T., Smith, S., Dart, A., Little, C. (2008). Focal injury induces widespread pathology in equine superficial digital flexor tendons. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
  • Melrose, J., Fuller, E., Roughley, P., Smith, M., Kerr, B., Hughes, C., Caterson, B., Little, C. (2008). Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Research & Therapy, 10(doi:10.1186/ar2453), 1-10. [More Information]
  • Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gilles, R., Dart, A., Sonnabend, D., Little, C. (2008). Modulation of Aggrecan and ADAMTS Expression in Ovine Tendinopathy Induced by Altered Strain. Seminars in Arthritis and Rheumatism, 58(4), 1055-1066. [More Information]
  • Smith, M., Cake, M., Ghosh, P., Schiavinato, A., Read, R., Little, C. (2008). Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Print Edition), 47(8), 1172-1178. [More Information]
  • Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Spacio-temporal changes in pathology and proteoglycan gene expression in shoulder tendons induced by overstress or stress deprivation. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
  • Cake, M., Smith, M., Young, A., Smith, S., Ghosh, P., Read, R. (2008). Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan). Clinical and Experimental Rheumatology, 26(4), 561-567. [More Information]
  • Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Temporal change in proteoglycan gene expression and histopathology induced in sheep shoulder tendons by altered stress in vivo. Osteoarthritis Research Society International World Congress on Osteoarthritis OARSI 2008, United States: Osteoarthritis Research Society International.
  • Melrose, J., Smith, S., Smith, M., Little, C. (2008). The use of Histochoice (tmR) for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotechnic and Histochemistry, 83(1), 47-53. [More Information]

2007

  • Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. (2007). Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical Orthopaedics and Related Research, 462, 212-220. [More Information]
  • Smith, M., Little, C. (2007). Experimental Models of Osteoarthritis. In Moskowitz, Altman, Hochberg, Buckwalter & Glodberg (Eds.), Osteoarthritis: Diagnosis and Medical/ Surgical Management, (pp. 107-125). Philadelphia, USA: Lippincott Williams & Wilkins.

2006

  • Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research & Therapy, 8(2), 1-6. [More Information]

2005

  • Cake, M., Appleyard, R., Read, R., Ghosh, P., Murrell, G., Smith, M. (2005). Ovariectomy alters the structural and biomechanical properties of ovine femoro-tibial articular cartilage and increases cartilage iNOS. Osteoarthritis and Cartilage, 13(12), 1066-1075. [More Information]
  • Smith, M. (2005). Preclinical Studies on the Pharmacology of Hyaluronan in Relation to its Application as an Intra-Articular Therapy for the Treatment of Osteoarthritis. In E.A. Balazs and V.C. Hascall (Eds.), Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications, (pp. 491-502). New Jersey: Matrix Biology Inst.

2002

  • Ghosh, P., Smith, M. (2002). Osteoarthritis, genetic and molecular mechanisms. Biogerontology, 3(1-2), 85-88.

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