Dr Monica Miranda Saksena

Senior Research Fellow
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 86273624

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Selected grants

2014

  • The mechanism of HSV-1 transport in sensory axons and its unique assembly at the axon terminus; Cunningham A, Diefenbach R, Miranda Saksena M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Transport, assembly and egress of Herpes Simplex virus in neurones; Cunningham A, Diefenbach R, Miranda Saksena M; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Biological probes for understanding mammalian cellular transport mechanisms; Diefenbach R, Miranda Saksena M, Cunningham A; Australian Research Council (ARC)/Linkage Projects (LP).

2006

  • Transport and egress of herpes simplex virus in neurones; Cunningham A, Diefenbach R, Miranda Saksena M; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Diefenbach, R., Miranda Saksena, M., Cunningham, A. (2011). Herpes simplex virus: Microtubule-dependent transport and egress from neurons. In Russell J Diefenbach and Anthony L Cunningham (Eds.), Viral Transport, Assembly and Egress, (pp. 49-78). Kerala, India: Research Signpost.

Journals

  • Talaei Zanjani, N., Sairi, F., Marshall, G., Miranda Saksena, M., Valtchev, P., Gomes, V., Cunningham, A., Dehghani, F. (2014). Formulation of abalone hemocyanin with high antiviral activity and stability. European Journal of Pharmaceutical Sciences, 53(1), 77-85. [More Information]
  • Cunningham, A., Miranda Saksena, M., Diefenbach, R., Johnson, D. (2013). Letter in response to: Making the case: Married versus Separate models of alphaherpes virus anterograde transport in axons. Reviews in Medical Virology, 23(6), 414-418. [More Information]
  • Wu, J., Sasse, T., Miranda Saksena, M., Saksena, N. (2013). Transcriptome analysis of primary monocytes from HIV-positive patients with differential responses to antiretroviral therapy. Virology Journal, 10, 1-16. [More Information]
  • Wu, J., Sasse, T., Wolkenstein, G., Conceicao, V., Miranda Saksena, M., Soedjono, M., Perera, S., Wang, B., Dwyer, D., Saksena, N. (2013). Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors. Virology, 435(2), 308-319. [More Information]
  • Aggarwal, A., Miranda Saksena, M., Boadle, R., Kelly, B., Diefenbach, R., Alam, W., Cunningham, A. (2012). Ultrastructural Visualization of Individual Tegument Protein Dissociation during Entry of Herpes Simplex Virus 1 into Human and Rat Dorsal Root Ganglion Neurons. Journal of Virology, 86(11), 6123-6137. [More Information]
  • Sandgren, K., Wilkinson, J., Miranda Saksena, M., McInerney, G., Byth, K., Robinson, P., Cunningham, A. (2010). A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells. PLoS Pathogens, 6(4), e1000866-1-e1000866-16. [More Information]
  • Lau, K., Wang, B., Miranda Saksena, M., Boadle, R., Kamarulzaman, A., Ng, K., Saksena, N. (2010). Evidence for Possible Biological Advantages of the Newly Emerging HIV-1 Circulating Recombinant Form from Malaysia - CRF33_01B in Comparison to its Progenitors _ CRF01_AE and Subtype B. Current HIV Research, 8(3), 259-271. [More Information]
  • Miranda Saksena, M., Boadle, R., Aggarwal, A., Tijono, B., Rixon, F., Diefenbach, R., Cunningham, A. (2009). Herpes simplex virus utilizes the large secretory vesicle pathway for anterograde transport of tegument and envelope proteins and for viral exocytosis from growth cones of human fetal axons. Journal of Virology, 83(7), 3187-3199. [More Information]
  • Diefenbach, R., Miranda Saksena, M., Douglas, M., Cunningham, A. (2008). Transport and egress of herpes simplex virus in neurons. Reviews in Medical Virology, 18(1), 35-51. [More Information]
  • Gowrishankar, K., Slobedman, B., Cunningham, A., Miranda Saksena, M., Boadle, R., Abendroth, A. (2007). Productive varicella-zoster virus infection of cultured intact human ganglia. Journal of Virology, 81(12), 6752-6756. [More Information]
  • Miranda Saksena, M., Wakisaka, H., Tijono, B., Boadle, R., Rixon, F., Takahashi, H., Cunningham, A. (2006). Herpes simplex virus type 1 accumulation, envelopment, and exit in growth cones and varicosities in mid-distal regions of axons. Journal of Virology, 80(7), 3592-3606. [More Information]
  • Cunningham, A., Diefenbach, R., Miranda Saksena, M., Bosnjak, L., Kim, M., Jones, C., Douglas, M. (2006). The cycle of human herpes simplex virus infection: virus transport and immune control. The Journal of Infectious Diseases, 194(Supplement 1), S11-S18. [More Information]
  • Bosnjak, L., Miranda Saksena, M., Koeller, D., Boadle, R., Jones, C., Cunningham, A. (2005). Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells. Journal of Immunology, 174(4), 2220-2227. [More Information]
  • Douglas, M., Diefenbach, R., Homa, F., Miranda Saksena, M., Rixon, F., Vittone, V., Byth Wilson, K., Cunningham, A. (2004). Herpes Simplex Virus Type 1 Capsid Protein Vp26 Interacts With Dynein Light Chains Rp3 And Tctex1 And Plays A Role In Retrograde Cellular Transport. Journal of Biological Chemistry, 279(27), 28522-28530.
  • Zaunders, J., Dyer, W., Wang, B., Munier, M., Miranda Saksena, M., Newton, R., Moore, J., Mackay, C., Cooper, D., Saksena, N., et al (2004). Identification Of Circulating Antigen-Specific Cd4+ T Lymphocytes With A Ccr5+, Cytotoxic Phenotype In An Hiv-1 Long-Term Nonprogressor And In Cmv Infection. Blood, 103(6), 2238-2247.
  • Turville, S., Santos, J., Frank, I., Cameron, P., Wilkinson, J., Miranda Saksena, M., Dable, J., Stoessel, H., Romani, N., Piatak, M., Cunningham, A., et al (2004). Immunodeficiency Virus Uptake, Turnover, And 2-Phase Transfer In Human Dendritic Cells. Blood, 103(6), 2170-9.
  • Jones, C., Fernandez, M., Herc, K., Bosnjak, L., Miranda Saksena, M., Boadle, R., Cunningham, A. (2003). Herpes Simplex virus type 2 inducses rapid cell death and functional impariment of murine dendritic cells invitro. Journal of Virology, 77(20), 11139-11149.
  • Diefenbach, R., Miranda Saksena, M., Diefenbach, E., Holland, D., Boadle, R., Armati, P., Cunningham, A. (2002). Herpes Simplex Virus Tegument Protein US11 Interacts with Conventional Kinesin Heavy Chain. Journal of Virology, 76(7), 3282-3291.
  • Miranda Saksena, M., Boadle, R., Armati, P., Cunningham, A. (2002). In Rat Dorsal Root Ganglion Neurons, Herpes Simplex Virus Type 1 Tegument Forms in the Cytoplasm of the Cell Body. Journal of Virology, 76(19), 9934-9951.

Patents

  • Cunningham, A., Diefenbach, R., Miranda Saksena, M., Diefenbach, E., Holland, D., Armati, P., Penfold, M. (2005). Patent No. 6953661.

2014

  • Talaei Zanjani, N., Sairi, F., Marshall, G., Miranda Saksena, M., Valtchev, P., Gomes, V., Cunningham, A., Dehghani, F. (2014). Formulation of abalone hemocyanin with high antiviral activity and stability. European Journal of Pharmaceutical Sciences, 53(1), 77-85. [More Information]

2013

  • Cunningham, A., Miranda Saksena, M., Diefenbach, R., Johnson, D. (2013). Letter in response to: Making the case: Married versus Separate models of alphaherpes virus anterograde transport in axons. Reviews in Medical Virology, 23(6), 414-418. [More Information]
  • Wu, J., Sasse, T., Miranda Saksena, M., Saksena, N. (2013). Transcriptome analysis of primary monocytes from HIV-positive patients with differential responses to antiretroviral therapy. Virology Journal, 10, 1-16. [More Information]
  • Wu, J., Sasse, T., Wolkenstein, G., Conceicao, V., Miranda Saksena, M., Soedjono, M., Perera, S., Wang, B., Dwyer, D., Saksena, N. (2013). Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors. Virology, 435(2), 308-319. [More Information]

2012

  • Aggarwal, A., Miranda Saksena, M., Boadle, R., Kelly, B., Diefenbach, R., Alam, W., Cunningham, A. (2012). Ultrastructural Visualization of Individual Tegument Protein Dissociation during Entry of Herpes Simplex Virus 1 into Human and Rat Dorsal Root Ganglion Neurons. Journal of Virology, 86(11), 6123-6137. [More Information]

2011

  • Diefenbach, R., Miranda Saksena, M., Cunningham, A. (2011). Herpes simplex virus: Microtubule-dependent transport and egress from neurons. In Russell J Diefenbach and Anthony L Cunningham (Eds.), Viral Transport, Assembly and Egress, (pp. 49-78). Kerala, India: Research Signpost.

2010

  • Sandgren, K., Wilkinson, J., Miranda Saksena, M., McInerney, G., Byth, K., Robinson, P., Cunningham, A. (2010). A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells. PLoS Pathogens, 6(4), e1000866-1-e1000866-16. [More Information]
  • Lau, K., Wang, B., Miranda Saksena, M., Boadle, R., Kamarulzaman, A., Ng, K., Saksena, N. (2010). Evidence for Possible Biological Advantages of the Newly Emerging HIV-1 Circulating Recombinant Form from Malaysia - CRF33_01B in Comparison to its Progenitors _ CRF01_AE and Subtype B. Current HIV Research, 8(3), 259-271. [More Information]

2009

  • Miranda Saksena, M., Boadle, R., Aggarwal, A., Tijono, B., Rixon, F., Diefenbach, R., Cunningham, A. (2009). Herpes simplex virus utilizes the large secretory vesicle pathway for anterograde transport of tegument and envelope proteins and for viral exocytosis from growth cones of human fetal axons. Journal of Virology, 83(7), 3187-3199. [More Information]

2008

  • Diefenbach, R., Miranda Saksena, M., Douglas, M., Cunningham, A. (2008). Transport and egress of herpes simplex virus in neurons. Reviews in Medical Virology, 18(1), 35-51. [More Information]

2007

  • Gowrishankar, K., Slobedman, B., Cunningham, A., Miranda Saksena, M., Boadle, R., Abendroth, A. (2007). Productive varicella-zoster virus infection of cultured intact human ganglia. Journal of Virology, 81(12), 6752-6756. [More Information]

2006

  • Miranda Saksena, M., Wakisaka, H., Tijono, B., Boadle, R., Rixon, F., Takahashi, H., Cunningham, A. (2006). Herpes simplex virus type 1 accumulation, envelopment, and exit in growth cones and varicosities in mid-distal regions of axons. Journal of Virology, 80(7), 3592-3606. [More Information]
  • Cunningham, A., Diefenbach, R., Miranda Saksena, M., Bosnjak, L., Kim, M., Jones, C., Douglas, M. (2006). The cycle of human herpes simplex virus infection: virus transport and immune control. The Journal of Infectious Diseases, 194(Supplement 1), S11-S18. [More Information]

2005

  • Bosnjak, L., Miranda Saksena, M., Koeller, D., Boadle, R., Jones, C., Cunningham, A. (2005). Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells. Journal of Immunology, 174(4), 2220-2227. [More Information]
  • Cunningham, A., Diefenbach, R., Miranda Saksena, M., Diefenbach, E., Holland, D., Armati, P., Penfold, M. (2005). Patent No. 6953661.

2004

  • Douglas, M., Diefenbach, R., Homa, F., Miranda Saksena, M., Rixon, F., Vittone, V., Byth Wilson, K., Cunningham, A. (2004). Herpes Simplex Virus Type 1 Capsid Protein Vp26 Interacts With Dynein Light Chains Rp3 And Tctex1 And Plays A Role In Retrograde Cellular Transport. Journal of Biological Chemistry, 279(27), 28522-28530.
  • Zaunders, J., Dyer, W., Wang, B., Munier, M., Miranda Saksena, M., Newton, R., Moore, J., Mackay, C., Cooper, D., Saksena, N., et al (2004). Identification Of Circulating Antigen-Specific Cd4+ T Lymphocytes With A Ccr5+, Cytotoxic Phenotype In An Hiv-1 Long-Term Nonprogressor And In Cmv Infection. Blood, 103(6), 2238-2247.
  • Turville, S., Santos, J., Frank, I., Cameron, P., Wilkinson, J., Miranda Saksena, M., Dable, J., Stoessel, H., Romani, N., Piatak, M., Cunningham, A., et al (2004). Immunodeficiency Virus Uptake, Turnover, And 2-Phase Transfer In Human Dendritic Cells. Blood, 103(6), 2170-9.

2003

  • Jones, C., Fernandez, M., Herc, K., Bosnjak, L., Miranda Saksena, M., Boadle, R., Cunningham, A. (2003). Herpes Simplex virus type 2 inducses rapid cell death and functional impariment of murine dendritic cells invitro. Journal of Virology, 77(20), 11139-11149.

2002

  • Diefenbach, R., Miranda Saksena, M., Diefenbach, E., Holland, D., Boadle, R., Armati, P., Cunningham, A. (2002). Herpes Simplex Virus Tegument Protein US11 Interacts with Conventional Kinesin Heavy Chain. Journal of Virology, 76(7), 3282-3291.
  • Miranda Saksena, M., Boadle, R., Armati, P., Cunningham, A. (2002). In Rat Dorsal Root Ganglion Neurons, Herpes Simplex Virus Type 1 Tegument Forms in the Cytoplasm of the Cell Body. Journal of Virology, 76(19), 9934-9951.

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